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CRNN Gene

protein-coding   GIFtS: 55
GCID: GC01M152381

Cornulin

(Previous name: chromosome 1 open reading frame 10)
(Previous symbol: C1orf10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
cornulin1 2     58 KDa Heat Shock Protein2 3
C1orf101 2 3     DRC12 3
Squamous Epithelial Heat Shock Protein 532 3     PDRC12 3
Tumor-Related Protein2 3     SEP532 3
53 KDa Putative Calcium-Binding Protein2 3     Chromosome 1 Open Reading Frame 101
53 KDa Squamous Epithelial-Induced Stress Protein2 3     

External Ids:    HGNC: 12301   Entrez Gene: 498602   Ensembl: ENSG000001435367   OMIM: 6113125   UniProtKB: Q9UBG33   

Export aliases for CRNN gene to outside databases

Previous GC identifers: GC01M149195 GC01M150648 GC01M123755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRNN Gene:
This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and
multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus
and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous
epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal
differentiation. (provided by RefSeq, Jan 2009)

GeneCards Summary for CRNN Gene:
CRNN (cornulin) is a protein-coding gene. Diseases associated with CRNN include polyclonal hypergammaglobulinemia, and oral squamous cell carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RPTN.

UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3
Function: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines,
attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral
squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRNN gene promoter:
         AML1a   ATF-2   Olf-1   STAT5A   POU6F1 (c2)   NF-kappaB   LCR-F1   Ik-3   C/EBPalpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRNN promoter sequence
   Search Chromatin IP Primers for CRNN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRNN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CRNN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRNN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152381:  view genomic region     (about GC identifiers)

Start:
152,381,719 bp from pter      End:
152,386,750 bp from pter
Size:
5,032 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3 (See protein sequence)
Recommended Name: Cornulin  
Size: 495 amino acids; 53533 Da
Cofactor: Binds calcium
Subunit: Homodimer
Miscellaneous: Binds calcium with an affinity similar to that of the S100 proteins
Secondary accessions: B2RE60 Q8N613

Explore the universe of human proteins at neXtProt for CRNN: NX_Q9UBG3

Explore proteomics data for CRNN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRNN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057274.1  
    ENSEMBL proteins: 
     ENSP00000271835  

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    Cloud-Clone Corp. CLIAs for CRNN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR013787 S100_Ca-bd_sub
     IPR026792 Cornulin
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9UBG3

    ProtoNet protein and cluster: Q9UBG3

    1 Blocks protein domain: IPB001751 Calcium-binding protein

    UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3
    Domain: The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure
    to DCA
    Similarity: Belongs to the S100-fused protein family
    Similarity: Contains 1 EF-hand domain


    CRNN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRNN_HUMAN, Q9UBG3
    Function: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines,
    attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral
    squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest
    Induction: Up-regulated after heat shock, ponasterone A and deoxycholic acid

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS11056050
         
    CRNN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRNN:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CRNN:
    hsa-mir-335-5p (MIRT018209)

    Block miRNA regulation of human, mouse, rat CRNN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CRNN:
    hsa-miR-766 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidCRNN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CRNN (NM_016190)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRNN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRNN

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRNN_HUMAN, Q9UBG3: Cytoplasm. Note=Does not colocalize with TGM1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS14967811
    GO:0016020membrane IDA2980212
    GO:0070062extracellular vesicular exosome IDA19056867

    CRNN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRNN
    Interactions:

        Search GeneGlobe Interaction Network for CRNN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CRNN (Q9UBG33 ENSP000002718354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=2 
    ATG4BQ9Y4P13I2D: score=1 
    WHSC1L1ENSP000003139834STRING: ENSP00000313983
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009408response to heat IDA11606197
    GO:0016337cell-cell adhesion IDA2631556

    CRNN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRNN

    1 HMDB Compound for CRNN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRNN gene: 
    NM_016190.2  

    Unigene Cluster for CRNN:

    Cornulin
    Hs.242057  [show with all ESTs]
    Unigene Representative Sequence: BC030807
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000271835(uc001ezx.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CRNN:
    hsa-miR-766 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidCRNN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRNN
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    GenScript: all cDNA clones in your preferred vector: CRNN (NM_016190)
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    Primer
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    OriGene qPCR primer pairs and template standards for CRNN
    OriGene qSTAR qPCR primer pairs in human, mouse for CRNN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRNN
      QuantiTect SYBR Green Assays in human, mouse, rat CRNN
      QuantiFast Probe-based Assays in human, mouse, rat CRNN

    Additional mRNA sequence: 

    AF077831.1 AK291301.1 AK298640.1 AK316568.1 BC030807.1 

    1 DOTS entry:

    DT.85104176 

    Selected AceView cDNA sequences (see all 25):

    AF077831 NM_016190 BX282192 AL603032 AL602957 AW572298 BC030807 AL602976 
    AL703280 AL712514 BQ354050 BF827519 AW084388 AW265324 AW238371 AW238721 
    BE715334 AW238323 BE182831 BE181845 BE715315 AW238695 BF576119 BE715363 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRNN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAATCCAG
    CRNN Expression
    About this image

    CRNN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRNN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.242057

    UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3
    Tissue specificity: Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the
    granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular
    layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the
    squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin.
    Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or
    barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal
    esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented
    laryngopharyngeal reflux (LPR)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRNN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRNN gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crnn1 , 5 cornulin1, 5 71.04(n)1
    57.29(a)1
      3 (40.14 cM)5
    3814571  NM_001081200.11  NP_001074669.11 
     931447875 
    chicken
    (Gallus gallus)
    Aves CRNN6
    Gallus gallus cornulin (CRNN), mRNA.
    22(a)
    1 → many
    25(1132880-1134156)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    14(a)
    1 → many
    GL343369.1(7-2795)


    ENSEMBL Gene Tree for CRNN (if available)
    TreeFam Gene Tree for CRNN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRNN gene
    RPTN2  FLG22  TCHH2  HRNR2  FLG2  TCHHL12  
    2 SIMAP similar genes for CRNN using alignment to 1 protein entry:     CRNN_HUMAN:
    S100Z    S100A10

    CRNN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRNN (see all 225)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461386771,2
    --152381326(+) TGGTAA/TCACAA 1 -- ds50010--------
    rs1389871931,2
    --152381617(+) AACTAA/GTTGCT 1 -- ds50010--------
    rs1166990481,2
    F--152381621(+) AGTTGC/TTCTTC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1145472011,2
    C,F--152381638(+) AGGGAC/GTATGT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1421342541,2
    C--152381732(+) TTAAGA/GTTTTA 1 -- ut310--------
    rs730013181,2
    C,F--152381788(+) AAAATA/GGTCCT 1 -- ut315Minor allele frequency- G:0.29WA CSA 125
    rs1508604691,2
    C--152381803(+) CCCCCC/GACAAG 1 -- ut310--------
    rs730013191,2
    C,F--152381875(+) TGCACC/TGCAAA 1 -- ut315Minor allele frequency- T:0.31WA CSA 127
    rs1392955781,2
    --152381999(+) CTGGAC/TTGGCC 1 -- ut310--------
    rs1120815781,2
    F--152382006(+) GGCCAC/TGCAGG 1 -- ut311Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for CRNN (152381719 - 152386750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRNN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516541CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRNN
    DNA2.0 Custom Variant and Variant Library Synthesis for CRNN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611312    OMIM disorders: --

    12 diseases for CRNN:    
    About MalaCards
    polyclonal hypergammaglobulinemia    oral squamous cell carcinoma    oral leukoplakia    esophageal cancer
    leukoplakia    laryngitis    cervical cancer    esophagitis
    squamous cell carcinoma    cervicitis    esophageal squamous cell carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CRNN:
    Polyclonal hypergammaglobulinemia

    CRNN for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRNN
    Human Genome Epidemiology (HuGE) Navigator: CRNN (1 document)

    Export disorders for CRNN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRNN gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CRNN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation. (PubMed id 15854041)1, 2, 3, 9 Contzler R.... Hohl D. (J. Invest. Dermatol. 2005)
    2. Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer. (PubMed id 11056050)1, 2, 3 Xu Z.... Wu M. (Genomics 2000)
    3. Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population. (PubMed id 19558548)1, 4 Zhang W....Liu Z. (Cancer Sci. 2009)
    4. The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response. (PubMed id 11606197)1, 2 Yagui-Beltran A.... Hupp T.R. (Eur. J. Biochem. 2001)
    5. Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. (PubMed id 19133922)1, 9 LiedAcn A....D'Amato M. (Allergy 2009)
    6. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    7. Downregulation of cornulin in esophageal squamous cell carcinoma. (PubMed id 22560086)1 Pawar H....Kumar R.V. (Acta Histochem. 2013)
    8. Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma. (PubMed id 23894350)1 Chen K....Guan X.Y. (PLoS ONE 2013)
    9. Balance between SIRT1 and DBC1 expression is lost in breast cancer. (PubMed id 20412117)1 Sung J.Y....Lee J. (Cancer Sci. 2010)
    10. Common variants in the trichohyalin gene are associated with straight hair in Europeans. (PubMed id 19896111)4 Medland S.E....Martin N.G. (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 49860 HGNC: 1230 AceView: C1orf10 Ensembl:ENSG00000143536 euGenes: HUgn49860
    ECgene: CRNN H-InvDB: CRNN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRNN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRNN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRNN gene:
    Search GeneIP for patents involving CRNN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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