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Aliases for CRNN Gene

Aliases for CRNN Gene

  • Cornulin 2 3 5
  • 53 KDa Squamous Epithelial-Induced Stress Protein 3 4
  • Squamous Epithelial Heat Shock Protein 53 3 4
  • 53 KDa Putative Calcium-Binding Protein 3 4
  • 58 KDa Heat Shock Protein 3 4
  • Tumor-Related Protein 3 4
  • C1orf10 3 4
  • PDRC1 3 4
  • SEP53 3 4
  • DRC1 3 4
  • Chromosome 1 Open Reading Frame 10 2

External Ids for CRNN Gene

Previous HGNC Symbols for CRNN Gene

  • C1orf10

Previous GeneCards Identifiers for CRNN Gene

  • GC01M149195
  • GC01M150648
  • GC01M123755

Summaries for CRNN Gene

Entrez Gene Summary for CRNN Gene

  • This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

GeneCards Summary for CRNN Gene

CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include esophageal cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHH.

UniProtKB/Swiss-Prot for CRNN Gene

  • Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRNN Gene

Genomics for CRNN Gene

Regulatory Elements for CRNN Gene

Genomic Location for CRNN Gene

Chromosome:
1
Start:
152,409,243 bp from pter
End:
152,414,274 bp from pter
Size:
5,032 bases
Orientation:
Minus strand

Genomic View for CRNN Gene

Genes around CRNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRNN Gene

Proteins for CRNN Gene

  • Protein details for CRNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBG3-CRNN_HUMAN
    Recommended name:
    Cornulin
    Protein Accession:
    Q9UBG3
    Secondary Accessions:
    • B2RE60
    • Q8N613

    Protein attributes for CRNN Gene

    Size:
    495 amino acids
    Molecular mass:
    53533 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Binds calcium with an affinity similar to that of the S100 proteins.

neXtProt entry for CRNN Gene

Proteomics data for CRNN Gene at MOPED

Post-translational modifications for CRNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRNN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CRNN Gene

Domains & Families for CRNN Gene

Gene Families for CRNN Gene

Suggested Antigen Peptide Sequences for CRNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBG3

UniProtKB/Swiss-Prot:

CRNN_HUMAN :
  • The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.
  • Belongs to the S100-fused protein family.
Domain:
  • The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.
  • Contains 1 EF-hand domain.
Family:
  • Belongs to the S100-fused protein family.
genes like me logo Genes that share domains with CRNN: view

Function for CRNN Gene

Molecular function for CRNN Gene

UniProtKB/Swiss-Prot Function:
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
UniProtKB/Swiss-Prot Induction:
Up-regulated after heat shock, ponasterone A and deoxycholic acid.
genes like me logo Genes that share phenotypes with CRNN: view

Animal Model Products

miRNA for CRNN Gene

miRTarBase miRNAs that target CRNN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRNN Gene

Localization for CRNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRNN Gene

Cytoplasm. Note=Does not colocalize with TGM1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRNN Gene COMPARTMENTS Subcellular localization image for CRNN gene
Compartment Confidence
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CRNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 14967811
genes like me logo Genes that share ontologies with CRNN: view

Pathways & Interactions for CRNN Gene

SuperPathways for CRNN Gene

No Data Available

Interacting Proteins for CRNN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000271835%0d%0a9606.ENSP00000378201%0d%0a9606.ENSP00000457230%0d%0a
Selected Interacting proteins: Q9UBG3-CRNN_HUMAN ENSP00000271835 for CRNN Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CRNN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRNN Gene

Drugs & Compounds for CRNN Gene

(1) Drugs for CRNN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CRNN: view

Transcripts for CRNN Gene

mRNA/cDNA for CRNN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRNN Gene

Cornulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRNN Gene

No ASD Table

Relevant External Links for CRNN Gene

GeneLoc Exon Structure for
CRNN
ECgene alternative splicing isoforms for
CRNN

Expression for CRNN Gene

mRNA expression in normal human tissues for CRNN Gene

mRNA differential expression in normal tissues according to GTEx for CRNN Gene

This gene is overexpressed in Esophagus - Mucosa (x34.4), Vagina (x10.0), and Cervix - Ectocervix (x6.2).

Protein differential expression in normal tissues from HIPED for CRNN Gene

This gene is overexpressed in Cervix (47.8), Saliva (7.9), and Urine (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRNN Gene



SOURCE GeneReport for Unigene cluster for CRNN Gene Hs.242057

mRNA Expression by UniProt/SwissProt for CRNN Gene

Q9UBG3-CRNN_HUMAN
Tissue specificity: Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
genes like me logo Genes that share expression patterns with CRNN: view

Protein tissue co-expression partners for CRNN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRNN Gene

Orthologs for CRNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRNN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRNN 35
  • 77.8 (n)
  • 65.79 (a)
CRNN 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRNN 35
  • 78.01 (n)
  • 63.88 (a)
CRNN 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crnn 35
  • 71.04 (n)
  • 57.29 (a)
Crnn 16
Crnn 36
  • 45 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRNN 35
  • 99.39 (n)
  • 98.59 (a)
CRNN 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crnn 35
  • 71.65 (n)
  • 57.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CRNN 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRNN 36
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 14 (a)
OneToMany
Species with no ortholog for CRNN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRNN Gene

ENSEMBL:
Gene Tree for CRNN (if available)
TreeFam:
Gene Tree for CRNN (if available)

Paralogs for CRNN Gene

Paralogs for CRNN Gene

(2) SIMAP similar genes for CRNN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRNN: view

Variants for CRNN Gene

Sequence variations from dbSNP and Humsavar for CRNN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35639220 - 152,412,154(-) CACAG(C/T)GCTCA reference, missense
rs6695830 - 152,409,960(+) TGTCC(C/G/T)TGTTC reference, missense
rs3829868 - 152,409,644(+) GATGC(C/T)TCGCT reference, missense
rs1923491 -- 152,412,469(-) TCACA(C/T)CATAC intron-variant
rs1923492 -- 152,412,357(-) AGGAA(A/G)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRNN Gene

Variant ID Type Subtype PubMed ID
nsv516541 CNV Loss 19592680

Variation tolerance for CRNN Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRNN Gene

HapMap Linkage Disequilibrium report
CRNN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRNN Gene

Disorders for CRNN Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRNN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CRNN in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRNN

Genetic Association Database (GAD)
CRNN
Human Genome Epidemiology (HuGE) Navigator
CRNN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRNN
genes like me logo Genes that share disorders with CRNN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRNN Gene

Publications for CRNN Gene

  1. Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation. (PMID: 15854041) Contzler R. … Hohl D. (J. Invest. Dermatol. 2005) 2 3 4 23 67
  2. Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. (PMID: 19133922) LiedAcn A. … D'Amato M. (Allergy 2009) 3 23
  3. Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer. (PMID: 11056050) Xu Z. … Wu M. (Genomics 2000) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3

Products for CRNN Gene

Sources for CRNN Gene

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