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Aliases for CRNN Gene

Aliases for CRNN Gene

  • Cornulin 2 3
  • 53 KDa Squamous Epithelial-Induced Stress Protein 3 4
  • Squamous Epithelial Heat Shock Protein 53 3 4
  • 53 KDa Putative Calcium-Binding Protein 3 4
  • 58 KDa Heat Shock Protein 3 4
  • Tumor-Related Protein 3 4
  • C1orf10 3 4
  • PDRC1 3 4
  • SEP53 3 4
  • DRC1 3 4
  • Chromosome 1 Open Reading Frame 10 2

External Ids for CRNN Gene

Previous Symbols for CRNN Gene

  • C1orf10

Summaries for CRNN Gene

Entrez Gene Summary for CRNN Gene

  • This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

GeneCards Summary for CRNN Gene

CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include polyclonal hypergammaglobulinemia and oral squamous cell carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHHL1.

UniProtKB/Swiss-Prot for CRNN Gene

  • Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRNN Gene

Genomics for CRNN Gene

Genomic Location for CRNN Gene

152,409,243 bp from pter
152,414,274 bp from pter
5,032 bases
Minus strand

Genomic View for CRNN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRNN Gene

Regulatory Elements for CRNN Gene

Proteins for CRNN Gene

  • Protein details for CRNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RE60
    • Q8N613

    Protein attributes for CRNN Gene

    495 amino acids
    Molecular mass:
    53533 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds Ca(2+).;
    Quaternary structure:
    • Homodimer.
    • Binds calcium with an affinity similar to that of the S100 proteins

neXtProt entry for CRNN Gene

Proteomics data for CRNN Gene at MOPED

Post-translational modifications for CRNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRNN Gene

Domains for CRNN Gene

Gene Families for CRNN Gene

  • EFHAND :EF-hand domain containing


  • The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA:
    • Q9UBG3
  • Contains 1 EF-hand domain.:
    • Q9UBG3
  • Belongs to the S100-fused protein family.:
    • Q9UBG3
genes like me logo Genes that share domains with CRNN: view

Function for CRNN Gene

Molecular function for CRNN Gene

UniProtKB/Swiss-Prot Function: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
UniProtKB/Swiss-Prot Induction: Up-regulated after heat shock, ponasterone A and deoxycholic acid.

Gene Ontology (GO) - Molecular Function for CRNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 11056050
genes like me logo Genes that share ontologies with CRNN: view

Phenotypes for CRNN Gene

GenomeRNAi human phenotypes for CRNN:
genes like me logo Genes that share phenotypes with CRNN: view

miRNA for CRNN Gene

miRTarBase miRNAs that target CRNN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRNN Gene

Localization for CRNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRNN Gene

Cytoplasm. Note=Does not colocalize with TGM1.

Subcellular locations from

Jensen Localization Image for CRNN Gene COMPARTMENTS Subcellular localization image for CRNN gene
Compartment Confidence
cytosol 3
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 14967811
GO:0016020 membrane IDA 2980212
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CRNN: view

Pathways for CRNN Gene

SuperPathways for CRNN Gene

No Data Available

Interacting Proteins for CRNN Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000271835 Q9UBG3-CRNN_HUMAN for CRNN Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CRNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat IDA 11606197
GO:0016337 single organismal cell-cell adhesion IDA 2631556
genes like me logo Genes that share ontologies with CRNN: view

No data available for Pathways by source for CRNN Gene

Compounds for CRNN Gene

(1) HMDB Compounds for CRNN Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CRNN: view

Transcripts for CRNN Gene

mRNA/cDNA for CRNN Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRNN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRNN Gene

No ASD Table

Relevant External Links for CRNN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRNN Gene

mRNA expression in normal human tissues for CRNN Gene

mRNA differential expression in normal tissues according to GTEx for CRNN Gene

This gene is overexpressed in Esophagus - Mucosa (34.4), Vagina (10.0), and Cervix - Ectocervix (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRNN Gene

SOURCE GeneReport for Unigene cluster for CRNN Gene Hs.242057

mRNA Expression by UniProt/SwissProt for CRNN Gene

Tissue specificity: Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
genes like me logo Genes that share expressions with CRNN: view

Orthologs for CRNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRNN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRNN 36
  • 99.39 (n)
  • 98.59 (a)
  • 96 (a)
(Bos Taurus)
Mammalia CRNN 36
  • 77.8 (n)
  • 65.79 (a)
  • 60 (a)
(Canis familiaris)
Mammalia CRNN 36
  • 78.01 (n)
  • 63.88 (a)
  • 55 (a)
(Mus musculus)
Mammalia Crnn 36
  • 71.04 (n)
  • 57.29 (a)
Crnn 16
Crnn 37
  • 45 (a)
(Monodelphis domestica)
Mammalia CRNN 37
  • 39 (a)
(Rattus norvegicus)
Mammalia Crnn 36
  • 71.65 (n)
  • 57.68 (a)
(Gallus gallus)
Aves CRNN 37
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 14 (a)
Species with no ortholog for CRNN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRNN Gene

Gene Tree for CRNN (if available)
Gene Tree for CRNN (if available)

Paralogs for CRNN Gene

Paralogs for CRNN Gene

Selected SIMAP similar genes for CRNN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRNN: view

Variants for CRNN Gene

Sequence variations from dbSNP and Humsavar for CRNN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1923491 -- 152,412,469(-) TCACA(C/T)CATAC intron-variant
rs1923492 -- 152,412,357(-) AGGAA(A/G)ACTAA intron-variant
rs1923493 -- 152,411,727(-) TGAAA(G/T)GTAAT intron-variant
rs3215709 -- 152,412,022(-) CCTTG(-/A)CCTGG intron-variant
rs3753443 -- 152,415,331(+) GAATA(C/T)GATGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRNN Gene

Variant ID Type Subtype PubMed ID
nsv516541 CNV Loss 19592680

Relevant External Links for CRNN Gene

HapMap Linkage Disequilibrium report

Disorders for CRNN Gene

(1) University of Copenhagen DISEASES for CRNN Gene

Relevant External Links for CRNN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRNN: view

No data available for UniProtKB/Swiss-Prot for CRNN Gene

Publications for CRNN Gene

  1. Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation. (PMID: 15854041) Contzler R. … Hohl D. (J. Invest. Dermatol. 2005) 2 3 4 23
  2. Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer. (PMID: 11056050) Xu Z. … Wu M. (Genomics 2000) 2 3 4
  3. The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response. (PMID: 11606197) Yagui-Beltran A. … Hupp T.R. (Eur. J. Biochem. 2001) 3 4
  4. Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. (PMID: 19133922) LiedAcn A. … D'Amato M. (Allergy 2009) 3 23
  5. Genetic variants of C1orf10 and risk of esophageal squamous cell carcinoma in a Chinese population. (PMID: 19558548) Zhang W. … Liu Z. (Cancer Sci. 2009) 3 49

Products for CRNN Gene

Sources for CRNN Gene

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