Aliases for CRNN Gene
External Ids for CRNN Gene
Previous HGNC Symbols for CRNN Gene
Previous GeneCards Identifiers for CRNN Gene
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
GeneCards Summary for CRNN Gene
CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include oral squamous cell carcinoma and esophageal cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHHL1.
UniProtKB/Swiss-Prot for CRNN Gene
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.