CRNN Gene
protein-coding GIFtS: 54
GCID: GC01M152381
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cornulin(Previous name: chromosome 1 open reading frame 10 ) (Previous symbol: C1orf10)
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Aliases for CRNN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Cornulin1 | | 53 KDa Squamous Epithelial-Induced Stress Protein2 3 | | C1orf101 2 3 | | 58 KDa Heat Shock Protein2 3 | | SEP531 2 3 | | DRC12 3 | | Squamous Epithelial Heat Shock Protein 532 3 | | PDRC12 3 | | Tumor-Related Protein2 3 | | Chromosome 1 Open Reading Frame 101 | | 53 KDa Putative Calcium-Binding Protein2 3 | | |
Export aliases for CRNN gene to outside databasesPrevious GC identifers: GC01M149195 GC01M150648 GC01M123755 |
Summaries for CRNN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CRNN: This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains andmultiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus andtwo glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamousepithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermaldifferentiation. (provided by RefSeq, Jan 2009) UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3Function: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines,attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oralsquamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest
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Genomic Views for CRNN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CRNN gene promoter: AML1a ATF-2 Olf-1 STAT5A POU6F1 (c2) NF-kappaB LCR-F1 Ik-3 C/EBPalpha NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for CRNN
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRNN |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21CRNN Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M152381: view genomic region
(about GC identifiers)
Start:
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152,381,719 bp from pter |
End:
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152,386,750 bp from pter |
Size:
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5,032 bases |
Orientation:
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minus strand |
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Proteins for CRNN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3 (See
protein sequence)Recommended Name: Cornulin Size: 495 amino acids; 53533 Da
Cofactor: Binds calcium
Subunit: Homodimer
Subcellular location: Cytoplasm. Note=Does not colocalize with TGM1
Miscellaneous: Binds calcium with an affinity similar to that of the S100 proteins
Secondary accessions: B2RE60 Q8N613Explore the universe of human proteins at neXtProt for CRNN: NX_Q9UBG3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBG3 CRNN Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_057274.1 ENSEMBL proteins: ENSP00000271835 Human Recombinant Protein Products for CRNN:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CRNN for ontologies About GeneDecksing
CRNN Antibody Products: Assay Products for CRNN: |
Protein
Domains / Families for CRNN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRNN for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBG3ProtoNet protein and cluster: Q9UBG3 1 Blocks protein family: IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3Domain: The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure toDCASimilarity: Belongs to the S100-fused protein familySimilarity: Contains 1 EF-hand domain |
Function for CRNN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: CRNN_HUMAN, Q9UBG3Function: Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines,attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oralsquamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrestInduction: Up-regulated after heat shock, ponasterone A and deoxycholic acid Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CRNN for ontologies About GeneDecksing
Phenotypes: 2 GenomeRNAi human phenotypes for CRNN: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRNN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRNN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRNN |
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Pathways & Interactions for CRNN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRNN
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 3 Interacting proteins for CRNN (Q9UBG33 ENSP000002718354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CRNN for ontologies About GeneDecksing
|
Drugs & Compounds for CRNN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CRNN
1 HMDB Compound for CRNN About this table Search CenterWatch for drugs/clinical trials and news about CRNN 
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Transcripts for CRNN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CRNN gene: NM_016190.2 Unigene Cluster for CRNN: Cornulin Hs.242057 [show with all ESTs]Unigene Representative Sequence: BC0308071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000271835(uc001ezx.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRNN (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRNN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CRNN (NM_016190) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRNN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRNN  |
Additional cDNA sequence: AF077831.1 AK291301.1 AK298640.1 AK316568.1 BC030807.1 1 DOTS entry: DT.85104176 24/25 AceView cDNA sequences (see all 25): NM_016190 AL603032 AF077831 BX282192 AL602976 BC030807 AL602957 AL703280 AW572298 AL712514 BQ354050 AW265324 AW084388 BF827519 AW238721 AW238371 BE182831 AW238323 BE181845 BE715334 BE715315 AW238695 BF576119 BE715363 GeneLoc Exon Structure
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Expression for CRNN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRNN expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCCAATCCAG
 About this image See CRNN Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CRNN
SOURCE GeneReport for Unigene cluster: Hs.242057
UniProtKB/Swiss-Prot: CRNN_HUMAN, Q9UBG3Tissue specificity: Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of thegranular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer),inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamousepithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed atvery low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectablein esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa.Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux(LPR) SABiosciences Custom PCR Arrays for CRNN
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRNN Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRNN | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRNN | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRNN | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRNN |
Orthologs for CRNN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CRNN gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for CRNN (if available) TreeFam Gene Tree for CRNN (if available)  |
Paralogs for CRNN gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CRNN gene
- FLG22 RPTN2 FLG2 HRNR2 TCHHL12
2 SIMAP similar genes for CRNN using alignment to 1 protein entry: CRNN_HUMAN:S100Z S100A10
CRNN for paralogs About GeneDecksing
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Genomic Variants for CRNN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for CRNN (152381719 - 152386750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CRNN 1 CNV: 48134  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRNN |
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Disorders
/ Diseases for CRNN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRNN for disorders About GeneDecksing
OMIM gene information: 611312
OMIM disorders: --
12 diseases for CRNN: About MalaCardspolyclonal hypergammaglobulinemia oral squamous cell carcinoma squamous cell carcinoma hypergammaglobulinemia eczema esophageal cancer cervical cancer esophagitis laryngitis cervicitis breast cancer carcinoma Human Genome Epidemiology (HuGE) Navigator: CRNN (1 document) Export disorders for CRNN gene to outside databases
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Publications for CRNN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRNN gene, integrated from 9 sources (see all 25): (articles sorted by number of sources associating them with CRNN) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cornulin, a new member of the 'fused gene' family, is expressed during epidermal differentiation. (PubMed id 15854041)1, 2, 3, 9 Contzler R.... Hohl D. (2005)
- Novel human esophagus-specific gene c1orf10: cDNA cloning, gene structure, and frequent loss of expression in esophageal cancer. (PubMed id 11056050)1, 2, 3 Xu Z.... Wu M. (2000)
- The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response. (PubMed id 11606197)1, 2 Yagui-Beltran A.... Hupp T.R. (2001)
- Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema. (PubMed id 19133922)1, 9 LiedAcn A....D'Amato M. (2009)
- The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
- Balance between SIRT1 and DBC1 expression is lost in breast cancer. (PubMed id 20412117)1 Sung J.Y....Lee J. (2010)
- Genetic variants of C1orf10 and risk of esophageal sq uamous cell carcinoma in a Chinese population. (PubMed id 19558548)1 Zhang W....Liu Z. (2009)
- An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses. (PubMed id 18465210)1 Nelson L....Hupp T. (2008)
- Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers. (PubMed id 17289885)2 Luthra M.G.... Luthra R. (2007)
- Adaptive evolution of a stress response protein. (PubMed id 17925851)1 Little T.J....Hupp T. (2007)
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External Searches for CRNN gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing CRNN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRNN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRNN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
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About This Section
| Patent Information for CRNN gene: Search GeneIP for patents involving CRNN
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CRNN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
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| |  |  |  |  | | | | | Recombinant Protein for CRNN |
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 | | CRNN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRNN |
|  |  |  |  | | | ThermoFisher Antibodies for CRNN |
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