Aliases for CRNN Gene
External Ids for CRNN Gene
Previous HGNC Symbols for CRNN Gene
Previous GeneCards Identifiers for CRNN Gene
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
GeneCards Summary for CRNN Gene
CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include esophageal cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHH.
UniProtKB/Swiss-Prot for CRNN Gene
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.