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CRNKL1 Gene

protein-coding   GIFtS: 57
GCID: GC20M019963

Crooked Neck Pre-MRNA Splicing Factor 1

(Previous names: crooked neck (Drosophila Crn homolog)-like 1, Crn, crooked...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crooked Neck Pre-MRNA Splicing Factor 11 2     HCRN2
CRN2 3 5     MSTP0212
SYF3 Pre-MRNA-Splicing Factor1 2     SYF32
Crooked Neck Homolog2 3     Crn, Crooked Neck-Like 12
Crn, Crooked Neck-Like 1 (Drosophila)1     Crooked Neck Pre-MRNA Splicing Factor-Like 12
Crooked Neck (Drosophila Crn Homolog)-Like 11     Crooked Neck-Like 12
Crooked Neck Pre-MRNA Splicing Factor-Like 1 (Drosophila)1     Crooked Neck-Like Protein 12
CLF2     hCrn3
Clf12     

External Ids:    HGNC: 157621   Entrez Gene: 513402   Ensembl: ENSG000001013437   OMIM: 6109525   UniProtKB: Q9BZJ03   

Export aliases for CRNKL1 gene to outside databases

Previous GC identifers: GC20M020003 GC20M020010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRNKL1 Gene:
The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell
cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to
pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced
transcript variants have been described. (provided by RefSeq, Jul 2013)

GeneCards Summary for CRNKL1 Gene:
CRNKL1 (crooked neck pre-mRNA splicing factor 1) is a protein-coding gene. Diseases associated with CRNKL1 include malaria. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: CRNL1_HUMAN, Q9BZJ0
Function: Involved in pre-mRNA splicing process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRNKL1 gene promoter:
         C/EBPbeta   STAT1   p53   Lmo2   STAT1beta   Nkx2-5   STAT1alpha   Ik-2   HNF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRNKL1 promoter sequence
   Search Chromatin IP Primers for CRNKL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRNKL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.2

CRNKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRNKL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M019963:  view genomic region     (about GC identifiers)

Start:
20,015,012 bp from pter      End:
20,036,690 bp from pter
Size:
21,679 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRNL1_HUMAN, Q9BZJ0 (See protein sequence)
Recommended Name: Crooked neck-like protein 1  
Size: 848 amino acids; 100452 Da
Subunit: Identified in the spliceosome C complex. Present in a spliceosome complex assembled in vitro containing
CRNKL1, HPRP8BP and SNRPB2. Isoform 2 seems to be predominant in the spliceosome complex
Sequence caution: Sequence=BAB14303.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14485.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K9T4 Q5JY64 Q8WYI5 Q9BZI9 Q9BZJ1 Q9BZJ2 Q9GZW7 Q9H8F8 Q9NQH5 Q9NYD8
Alternative splicing: 5 isoforms:  Q9BZJ0-1   Q9BZJ0-2   Q9BZJ0-3   Q9BZJ0-4   Q9BZJ0-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CRNKL1: NX_Q9BZJ0

Explore proteomics data for CRNKL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRNKL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265554.1  NP_001265555.1  NP_001265556.1  NP_001265557.1  NP_057736.4  

    ENSEMBL proteins: 
     ENSP00000366544   ENSP00000366557   ENSP00000429226   ENSP00000428436   ENSP00000440733  

    CRNKL1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR003107 HAT
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9BZJ0

    ProtoNet protein and cluster: Q9BZJ0

    1 Blocks protein domain: IPB003107 RNA-processing protein

    UniProtKB/Swiss-Prot: CRNL1_HUMAN, Q9BZJ0
    Similarity: Belongs to the crooked-neck family
    Similarity: Contains 17 HAT repeats


    CRNKL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRNL1_HUMAN, Q9BZJ0
    Function: Involved in pre-mRNA splicing process

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA12084575
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    CRNKL1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CRNKL1:
     Abundance of large cells with   Decreased influenza A virus in  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRNKL1
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    miRNA
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    miRTarBase miRNAs that target CRNKL1:
    hsa-mir-186-5p (MIRT045227)

    Block miRNA regulation of human, mouse, rat CRNKL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRNKL1 (see all 13):
    hsa-miR-498 hsa-miR-3163 hsa-miR-545 hsa-miR-340 hsa-miR-1305 hsa-miR-1262 hsa-miR-335 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRNKL1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRNL1_HUMAN, Q9BZJ0: Nucleus speckle. Cytoplasm. Note=Colocalizes with core spliceosomal snRNP proteins. Also
    diffusely expressed in cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005681spliceosomal complex IDA11991638
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--

    CRNKL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRNKL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for CRNKL1):
        Spliceosome


    CRNKL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRNKL1
    Interactions:

        Search GeneGlobe Interaction Network for CRNKL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRNKL1 (Q9BZJ01, 2, 3 ENSP000003665574) via UniProtKB, MINT, STRING, and/or I2D (see all 324)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC12Q8WUD41, 2, ENSP000002923144EBI-1049701,EBI-2557572 MINT-8337101 MINT-8332064 STRING: ENSP00000292314
    BIDP559572, 3, ENSP000003188224MINT-8249509 I2D: score=2 STRING: ENSP00000318822
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=2 STRING: ENSP00000414006
    ENSG00000225998Q9Y3333, ENSP000004062804I2D: score=2 STRING: ENSP00000406280
    ENSG00000231502Q9Y3333, ENSP000004033454I2D: score=2 STRING: ENSP00000403345
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000245spliceosomal complex assembly IDA12084575
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006396RNA processing ----
    GO:0006397mRNA processing ----

    CRNKL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRNKL1 (CRNL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRNKL1 gene (5 alternative transcripts): 
    NM_001278625.1  NM_001278626.1  NM_001278627.1  NM_001278628.1  NM_016652.5  

    Unigene Cluster for CRNKL1:

    Crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
    Hs.171342  [show with all ESTs]
    Unigene Representative Sequence: NM_016652
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377327(uc002wrt.1) ENST00000377340(uc002wrs.3) ENST00000490910
    ENST00000496549 ENST00000536226 ENST00000521379 ENST00000490258
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CRNKL1 (see all 13):
    hsa-miR-498 hsa-miR-3163 hsa-miR-545 hsa-miR-340 hsa-miR-1305 hsa-miR-1262 hsa-miR-335 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCRNKL1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CRNKL1

    Additional mRNA sequence: 

    AB016840.1 AF111802.1 AF255443.2 AF318302.1 AF318303.1 AF318304.1 AF318305.1 AK022908.1 
    AK023246.1 AK023728.1 AK026342.1 AK292799.1 AL832435.1 BC144222.1 

    7 DOTS entries:

    DT.452702  DT.95353451  DT.100791876  DT.100791878  DT.97845114  DT.95375156  DT.439584 

    Selected AceView cDNA sequences (see all 164):

    AL832435 AI003171 BM460482 AU132316 BF056996 BM698147 AK022908 AA195019 
    CD644346 Z39888 BM462141 AU118295 AF111802 NM_016652 BP345645 AA825980 
    BQ681478 BM756354 CB242683 AA195126 BE222548 BM846705 BM770812 AL570166 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRNKL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAACTGT
    CRNKL1 Expression
    About this image

    CRNKL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRNKL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171342

    UniProtKB/Swiss-Prot: CRNL1_HUMAN, Q9BZJ0
    Tissue specificity: Widely expressed. Highly expressed in testis. Not expressed in brain and lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRNKL1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crnkl11 , 5 Crn, crooked neck-like 1 (Drosophila)1, 5 89.31(n)1
    96.32(a)1
      2 (71.28 cM)5
    668771  NM_025820.31  NP_080096.11 
     1459174795 
    chicken
    (Gallus gallus)
    Aves CRNKL11 crooked neck pre-mRNA splicing factor-like 1 (Drosophila) 81.62(n)
    93.38(a)
      421243  XM_419315.4  XP_419315.2 
    lizard
    (Anolis carolinensis)
    Reptilia CRNKL16
    crooked neck pre-mRNA splicing factor 1
    92(a)
    1 ↔ 1
    4(80521890-80539313)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.29752 Xenopus laevis transcribed sequence with strong similarity more 81.63(n)    CA790594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553272 similar to crooked neck protein 77.09(n)   393920  BC044369.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta crn1 , 3 mRNA splicing pre-mRNA splicing factor3
    crooked neck1
    68(a)3
    64.66(n)1
    70.03(a)1
      2F23
    312081  NM_057770.41  NP_477118.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F8.31 , 3 M03F8.31 62(a)3
    63.52(n)1
    63.72(a)1
      V(5942558-5944788)3
    1789791  NM_001129507.21  NP_001122979.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CLF1(YLR117C)4 Member of the NineTeen Complex (NTC) that contains more   --   12(384534-382471) 850808  NP_013218.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G417701 AT5G41770 60.25(n)
    60.46(a)
      834182  NM_123542.2  NP_198992.2 
    rice
    (Oryza sativa)
    Liliopsida Os.89272 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.37(n)    AK100478.1 


    ENSEMBL Gene Tree for CRNKL1 (if available)
    TreeFam Gene Tree for CRNKL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRNKL1 gene
    2 SIMAP similar genes for CRNKL1 using alignment to 2 protein entries:     CRNL1_HUMAN (see all proteins):
    DKFZp762M013    crn

    CRNKL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRNKL1 (see all 475)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2001781,2
    H--20014805(-) TTTTAG/AAAGGG 1 -- ds50015Minor allele frequency- A:0.00EA NS 434
    rs599715511,2
    C--20014815(+) AAAAA-/ACTTGA 1 -- ds50010--------
    rs114762971,2
    C--20014840(+) TGAGGT/-TTTTT 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1462494381,2
    C--20014870(+) GAACA-/TAAT  
            
    TAATT
    1 -- ds50010--------
    rs1135843751,2
    C--20014892(+) GCCATA/GTAACT 1 -- ds50012Minor allele frequency- G:0.10CSA WA 120
    rs1835685051,2
    --20014898(+) TAACTA/GTATCA 1 -- ds50010--------
    rs61322611,2
    C,F,H--20014955(+) TGAAAA/CTATCC 1 -- ds500132Minor allele frequency- N:0.00NS EA NA CSA WA 3406
    rs762982961,2
    C,F--20014988(+) TTAACG/AAAAGA 1 -- ds50012Minor allele frequency- A:0.31WA EA 238
    rs1393737231,2
    C--20015052(+) GAGTT-/GAG   
       GGTGG
    GAGAG
    1 -- ut310--------
    rs802533531,2
    C,F--20015107(+) TTTTCC/TTTCCA 1 -- ut311Minor allele frequency- T:0.07EA 120

    HapMap Linkage Disequilibrium report for CRNKL1 (20015012 - 20036690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CRNKL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3320CNV Insertion18451855
    nsv517467CNV Loss19592680
    nsv819555CNV Loss19587683
    nsv525682CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610952    OMIM disorders: --

    1 disease for CRNKL1:    
    About MalaCards
    malaria


    CRNKL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRNKL1
    Human Genome Epidemiology (HuGE) Navigator: CRNKL1 (1 document)

    Export disorders for CRNKL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRNKL1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CRNKL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload. (PubMed id 17296875)1, 4 Rame J.E....Dries D.L. (Hypertension 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Crooked neck is a component of the human spliceosome and implicated in the splicing process. (PubMed id 12084575)1, 2 Chung S.... Rymond B.C. (Biochim. Biophys. Acta 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Identification of the human crooked neck gene by comparative gene identification. (PubMed id 11342225)1, 2 Lai C.-H.... Lin W.-C. (Biochim. Biophys. Acta 2001)
    8. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51340 HGNC: 15762 AceView: CRNKL1 Ensembl:ENSG00000101343 euGenes: HUgn51340
    ECgene: CRNKL1 Kegg: 51340 H-InvDB: CRNKL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRNKL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRNKL1 gene:
    Search GeneIP for patents involving CRNKL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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