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Aliases for CRNDE Gene

Aliases for CRNDE Gene

  • Colorectal Neoplasia Differentially Expressed 2 3 5
  • Colorectal Neoplasia Differentially Expressed (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 180 2 3
  • Colorectal Neoplasia Differentially Expressed Peptide 3
  • NCRNA00180 3
  • LINC00180 3
  • PNAS-108 3
  • LincIRX5 3
  • CRNDEP 3

External Ids for CRNDE Gene

Previous GeneCards Identifiers for CRNDE Gene

  • GC16M053512
  • GC16M054953
  • GC16M040838

Summaries for CRNDE Gene

Entrez Gene Summary for CRNDE Gene

  • This gene is transcribed into multiple transcript variants, some of which may function as non-coding RNAs. One of the transcript variants encodes a putative short protein that is localized to the nucleus (PMID:25978564). Expression of this locus is increased in proliferating tissues, including certain tumors such as colorectal adenomas and adenocarcinomas. Transcription from this gene is negatively regulated by insulin and insulin-like growth factors, and may regulate the expression of genes involved in metabolism. [provided by RefSeq, May 2015]

GeneCards Summary for CRNDE Gene

CRNDE (Colorectal Neoplasia Differentially Expressed) is a Protein Coding gene.

Additional gene information for CRNDE Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRNDE Gene

Genomics for CRNDE Gene

Regulatory Elements for CRNDE Gene

Enhancers for CRNDE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H054920 1.7 dbSUPER 7.7 +6.2 6210 4.6 PKNOX1 INSM2 FEZF1 ZNF664 POLR2A ZNF366 PRDM10 KLF8 OVOL3 ZEB2 IRX3 CRNDE GC16M054907
GH16H054926 1.3 ENCODE dbSUPER 8 -3.4 -3364 12.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF143 SP3 REST SMARCB1 IRX3 CRNDE IRX5 ENSG00000259711
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRNDE on UCSC Golden Path with GeneCards custom track

Promoters for CRNDE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CRNDE Gene

Genomic Locations for CRNDE Gene
84,001 bases
Minus strand

Genomic View for CRNDE Gene

Genes around CRNDE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRNDE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRNDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRNDE Gene

Proteins for CRNDE Gene

Post-translational modifications for CRNDE Gene

No Post-translational modifications

Other Protein References for CRNDE Gene

No data available for DME Specific Peptides for CRNDE Gene

Domains & Families for CRNDE Gene

Gene Families for CRNDE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRNDE: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CRNDE Gene

Function for CRNDE Gene

Phenotypes for CRNDE Gene

GenomeRNAi human phenotypes for CRNDE:
genes like me logo Genes that share phenotypes with CRNDE: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRNDE Gene

Localization for CRNDE Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRNDE gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CRNDE Gene

Pathways & Interactions for CRNDE Gene

SuperPathways for CRNDE Gene

No Data Available

Interacting Proteins for CRNDE Gene

Gene Ontology (GO) - Biological Process for CRNDE Gene


No data available for Pathways by source and SIGNOR curated interactions for CRNDE Gene

Drugs & Compounds for CRNDE Gene

No Compound Related Data Available

Transcripts for CRNDE Gene

mRNA/cDNA for CRNDE Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRNDE Gene

Colorectal neoplasia differentially expressed (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRNDE Gene

No ASD Table

Relevant External Links for CRNDE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRNDE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRNDE Gene

mRNA differential expression in normal tissues according to GTEx for CRNDE Gene

This gene is overexpressed in Testis (x10.7).

NURSA nuclear receptor signaling pathways regulating expression of CRNDE Gene:


SOURCE GeneReport for Unigene cluster for CRNDE Gene:

genes like me logo Genes that share expression patterns with CRNDE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRNDE Gene

Orthologs for CRNDE Gene

Evolution for CRNDE Gene

Gene Tree for CRNDE (if available)
Gene Tree for CRNDE (if available)

No data available for Orthologs for CRNDE Gene

Paralogs for CRNDE Gene

No data available for Paralogs for CRNDE Gene

Variants for CRNDE Gene

Sequence variations from dbSNP and Humsavar for CRNDE Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000217083 -- 54,928,325(+) AGACA(A/G)TACAA intron-variant, upstream-variant-2KB
rs1000520352 -- 54,926,720(+) AAAAC(A/G)GTTTT intron-variant
rs1000588505 -- 54,928,074(+) GTCTG(C/G)CTGCT intron-variant, utr-variant-5-prime
rs1001195200 -- 54,929,479(+) AAATA(A/C)AGTAC upstream-variant-2KB
rs1001625127 -- 54,929,694(+) AAGAG(A/G)AGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRNDE Gene

Variant ID Type Subtype PubMed ID
nsv827657 CNV gain 20364138

Relevant External Links for CRNDE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CRNDE Gene

Disorders for CRNDE Gene

Relevant External Links for CRNDE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRNDE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRNDE Gene

Publications for CRNDE Gene

  1. The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues. (PMID: 25978564) Szafron LM … Kupryjanczyk J (PloS one 2015) 2 3 60
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M … Rinn JL (eLife 2013) 2 3 60
  3. CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment. (PMID: 23226159) Ellis BC … Graham LD (Frontiers in genetics 2012) 2 3 60
  4. The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. (PMID: 28086904) Han P … Cui BB (Molecular cancer 2017) 3 60
  5. The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway. (PMID: 28472810) Yu B … Li XX (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60

Products for CRNDE Gene

Sources for CRNDE Gene

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