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Aliases for CRNDE Gene

Subcategory (RNA class) for CRNDE Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CRNDE Gene

  • Colorectal Neoplasia Differentially Expressed (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 180 2 3
  • NCRNA00180 3
  • LINC00180 3
  • PNAS-108 3
  • LincIRX5 3
  • CRNDEP 3

External Ids for CRNDE Gene

Previous GeneCards Identifiers for CRNDE Gene

  • GC16M053512
  • GC16M040838

Summaries for CRNDE Gene

Entrez Gene Summary for CRNDE Gene

  • This gene is transcribed into multiple transcript variants, some of which may function as non-coding RNAs. One of the transcript variants encodes a putative short protein that is localized to the nucleus (PMID:25978564). Expression of this locus is increased in proliferating tissues, including certain tumors such as colorectal adenomas and adenocarcinomas. Transcription from this gene is negatively regulated by insulin and insulin-like growth factors, and may regulate the expression of genes involved in metabolism. [provided by RefSeq, May 2015]

GeneCards Summary for CRNDE Gene

CRNDE (Colorectal Neoplasia Differentially Expressed (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with CRNDE include uveal melanoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRNDE Gene

Genomics for CRNDE Gene

Regulatory Elements for CRNDE Gene

Promoters for CRNDE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRNDE on UCSC Golden Path with GeneCards custom track

Genomic Location for CRNDE Gene

Chromosome:
16
Start:
54,918,863 bp from pter
End:
54,929,189 bp from pter
Size:
10,327 bases
Orientation:
Minus strand

Genomic View for CRNDE Gene

Genes around CRNDE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRNDE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRNDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRNDE Gene

Proteins for CRNDE Gene

Post-translational modifications for CRNDE Gene

No Post-translational modifications

Other Protein References for CRNDE Gene

REFSEQ proteins:

No data available for DME Specific Peptides for CRNDE Gene

Domains & Families for CRNDE Gene

Gene Families for CRNDE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRNDE: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CRNDE Gene

Function for CRNDE Gene

Phenotypes for CRNDE Gene

GenomeRNAi human phenotypes for CRNDE:
genes like me logo Genes that share phenotypes with CRNDE: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRNDE Gene

Localization for CRNDE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRNDE Gene COMPARTMENTS Subcellular localization image for CRNDE gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRNDE Gene

Pathways & Interactions for CRNDE Gene

SuperPathways for CRNDE Gene

No Data Available

Interacting Proteins for CRNDE Gene

Gene Ontology (GO) - Biological Process for CRNDE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRNDE Gene

Drugs & Compounds for CRNDE Gene

No Compound Related Data Available

Transcripts for CRNDE Gene

mRNA/cDNA for CRNDE Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRNDE Gene

Colorectal neoplasia differentially expressed (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRNDE Gene

No ASD Table

Relevant External Links for CRNDE Gene

GeneLoc Exon Structure for
CRNDE
ECgene alternative splicing isoforms for
CRNDE

Expression for CRNDE Gene

mRNA expression in normal human tissues for CRNDE Gene

mRNA differential expression in normal tissues according to GTEx for CRNDE Gene

This gene is overexpressed in Testis (x10.7).

SOURCE GeneReport for Unigene cluster for CRNDE Gene Hs.237396

genes like me logo Genes that share expression patterns with CRNDE: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CRNDE Gene

Orthologs for CRNDE Gene

Evolution for CRNDE Gene

ENSEMBL:
Gene Tree for CRNDE (if available)
TreeFam:
Gene Tree for CRNDE (if available)

No data available for Orthologs for CRNDE Gene

Paralogs for CRNDE Gene

No data available for Paralogs for CRNDE Gene

Variants for CRNDE Gene

Sequence variations from dbSNP and Humsavar for CRNDE Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs5006075 -- 54,918,400(+) CCTTT(C/G)TGGAC downstream-variant-500B
rs11643696 -- 54,926,407(+) ACATA(C/T)ACACT intron-variant
rs12447300 -- 54,928,224(+) ATTTG(A/G)CGTAG intron-variant
rs74888484 -- 54,922,691(+) ATACC(A/T)TTACA intron-variant
rs78999236 -- 54,925,498(+) ATTAG(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRNDE Gene

Variant ID Type Subtype PubMed ID
nsv827657 CNV Gain 20364138

Relevant External Links for CRNDE Gene

HapMap Linkage Disequilibrium report
CRNDE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CRNDE Gene

Disorders for CRNDE Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRNDE Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uveal melanoma
  • melanoma of uvea
- elite association - COSMIC cancer census association via MalaCards
Search CRNDE in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRNDE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRNDE
genes like me logo Genes that share disorders with CRNDE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRNDE Gene

Publications for CRNDE Gene

  1. The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues. (PMID: 25978564) Szafron L.M. … Kupryjanczyk J. (PLoS ONE 2015) 2 3 67
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M. … Rinn J.L. (Elife 2013) 2 3
  3. CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment. (PMID: 23226159) Ellis B.C. … Graham L.D. (Front Genet 2012) 2 3
  4. CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. (PMID: 25813405) Wang Y. … Han B. (Cancer Lett. 2015) 3
  5. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. (PMID: 24184209) Ellis B.C. … Molloy P.L. (Biochim. Biophys. Acta 2014) 3

Products for CRNDE Gene

Sources for CRNDE Gene

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