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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRMP1 Gene

protein-coding   GIFtS: 63
GCID: GC04M005815

collapsin response mediator protein 1
 Explore 14 diseases affiliated with
CRMP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRMP1    

Aliases
for CRMP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Collapsin Response Mediator Protein 11 2 3     DRP12 5
DPYSL11 2 3 5     Dihydropyrimidinase Related Protein-12
DRP-11 2 3     Dihydropyrimidinase-Like 12
Unc-33-Like Phosphoprotein 32 3     Dihydropyrimidinase-Related Protein 12
CRMP-12 3     ULIP33
ULIP-32 3     

External Ids:    HGNC: 23651   Entrez Gene: 14002   Ensembl: ENSG000000728327   OMIM: 6024625   UniProtKB: Q141943   

Export aliases for CRMP1 gene to outside databases

Previous GC identifers: GC04M005704 GC04P005871 GC04M005887 GC04M005940


Summaries
for CRMP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRMP1:
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The
encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced
growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in
axon guidance, invasive growth and cell migration

Gene Wiki entry for CRMP1


Genomic Views
for CRMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRMP1 gene promoter:
         NRSF form 1   MyoD   NRSF form 2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.2   HGNC cytogenetic band: 4p16.1

CRMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRMP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M005815:  view genomic region     (about GC identifiers)

Start:
 5,749,811 bp from pter      End:
 5,894,785 bp from pter
Size:
 144,975 bases      Orientation:
 minus strand

Proteins
for CRMP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194 (See protein sequence)
Recommended Name: Dihydropyrimidinase-related protein 1  
Size: 572 amino acids; 62184 Da
Subunit: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated
with centrosomes and the mitotic spindle during metaphase
Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for
dihydropyrimidinase activity. Its enzyme activity is therefore unsure
Secondary accessions: A0EJG6 Q13024 Q4W5F1 Q96TC8
Alternative splicing: 2 isoforms:  Q14194-1   Q14194-2   

Explore the universe of human proteins at neXtProt for CRMP1: NX_Q14194

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14194

    • CRMP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014809.1  NP_001304.1  

    ENSEMBL proteins: 
     ENSP00000321606   ENSP00000380987   ENSP00000425742   ENSP00000441150  
    Reactome Protein details: Q14194
    Human Recombinant Protein Products: 
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    Novus Biologicals CRMP1 Proteins
    Novus Biologicals CRMP1 Lysate
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    ProSpec Recombinant Protein for CRMP1
    Uscn Proteins for CRMP1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0030425dendrite IEA--


    CRMP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CRMP1

    Protein Domains /
    Families
    for CRMP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRMP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011778 Hydantoinase/dihydroPyrase
     IPR011059 Metal-dep_hydrolase_composite
     IPR006680 Amidohydro_1

    Graphical View of Domain Structure for InterPro Entry Q14194

    ProtoNet protein and cluster: Q14194

    2 Blocks protein families:
    IPB005847 Dihydroorotase region
    IPB011550 Amidohydrolase-like


    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily


    Function
    for CRMP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in
    axon guidance, invasive growth and cell migration

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CRMP1 (see all 26):
    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: CRMP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRMP1 (see all 6)
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CRMP1

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004157dihydropyrimidinase activity ----
    GO:0005515protein binding IPI16169070
    GO:0016812hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA--


    CRMP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CRMP1:
     Increased cell number in G1, s 

    Animal Models:
         Mouse knock-out Crmp1tm1.1Swl for CRMP1
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crmp1):
     behavior/neurological  cellular  nervous system 

    CRMP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRMP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Semaphorin Signaling
    		Semaphorin Signaling1.00
    3Guidance Cues and Growth Cone Motility
    		Guidance Cues and Growth Cone Motility1.00
    4Sema4D in semaphorin signaling
    		Semaphorin interactions0.44
    5SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    		CRMPs in Sema3A signaling0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRMP1
        Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    4        Reactome Pathways for CRMP1
        CRMPs in Sema3A signaling
    Developmental Biology
    Semaphorin interactions
    Axon guidance



    CRMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/116 Interacting proteins for CRMP1 (Q141941, 2, 3 ENSP000003216064) via UniProtKB, MINT, STRING, and/or I2D (see all 116)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3EBI-473101,EBI-710484 MINT-64312 I2D: score=4 
    TK1P041832, 3MINT-8273213 MINT-63369 I2D: score=4 
    CCL18P557742, 3MINT-63886 I2D: score=5 
    CDK5RAP2Q96SN82, 3MINT-65255 I2D: score=5 
    HNRNPH3P319422, 3MINT-63659 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS8973361
    GO:0006208pyrimidine nucleobase catabolic process IEA--
    GO:0007399nervous system development TAS8973361
    GO:0007411axon guidance TAS--


    CRMP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRMP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRMP1
    Search CenterWatch for drugs/clinical trials and news about CRMP1 / DPYL1 

    Transcripts
    for CRMP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRMP1 gene (2 alternative transcripts): 
    NM_001014809.1  NM_001313.3  

    Unigene Cluster for CRMP1:

    Collapsin response mediator protein 1
    Hs.135270  [show with all ESTs]
    Unigene Representative Sequence: NM_001014809
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506216 ENST00000324989(uc003gis.3) ENST00000397890(uc003giq.3)
    ENST00000513911 ENST00000511535 ENST00000512574(uc003gir.3) ENST00000534845


    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CRMP1 (see all 26):
    hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmid: CRMP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRMP1 (see all 6)
    OriGene siRNA: CRMP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRMP1
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRMP1

    Additional cDNA sequence: 

    AK091696.1 AK094725.1 AK122754.1 AK127754.1 AK309379.1 BC000252.1 BC007613.1 BC007898.2 
    BT006806.1 D78012.1 DQ206871.1 U17278.1 

    20 DOTS entries:

    DT.100762743  DT.100821208  DT.101983853  DT.100821182  DT.219724  DT.95087464  DT.100802877  DT.121270089 
    DT.100821181  DT.100821207  DT.121270099  DT.100821189  DT.100821214  DT.95087523  DT.100652789  DT.121270015 
    DT.121270062  DT.92448235  DT.102835332  DT.219725 

    24/379 AceView cDNA sequences (see all 379):

    CR601364 AW251064 BX441447 AW583346 BC007613 BE019357 AI299048 BX440698 
    AK094725 AI688714 BM799454 AW162899 AW732221 BM697311 AA449627 AI357768 
    BE207055 AW583553 AL535253 BM698495 AA948277 AL518319 T32217 NM_001313 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
    SP1:              -     -     -                             -                                                           -           -                           
    SP2:                                                        -                                                           -           -                           
    SP3:                                      -     -     -     -                                                                                                   
    SP4:                                      -                 -                                                                                                   
    SP5:              -     -     -                                                                                                                                 


    ECgene alternative splicing isoforms for CRMP1

    Expression
    for CRMP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRMP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRMP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Epiblast-like cells (Reconstitution of mo...)

    See CRMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRMP1

    SOURCE GeneReport for Unigene cluster: Hs.135270

    UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194
    Tissue specificity: Brain

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    In Situ
    Assay Products:     
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    Orthologs
    for CRMP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CRMP1 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CRMP11 collapsin response mediator protein 1 81.75(n)
    93.74(a)    		   395156  NM_204495.1  NP_989826.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CRMP16
    		 --
    		 85(a)
    		 1 ↔ 1
    		 5(80502955-80553498)
    zebrafish
    (Danio rerio)    		 Actinopterygii crmp11 collapsin response mediator protein 1 72.87(n)
    79.61(a)    		   553756  NM_001020725.1  NP_001018561.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dhp-23 Ulip like protein 48(a)
    (best of 3)    		   IV(9978361-9980884)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PYD26
    		 pyrimidine 2
    		 40(a)
    		 1 → many
    		 5(3941528-3944811)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 dihydropyrimidinase, putative, expressed
    		 40(a)
    		 1 → many
    		 1(34294608-34306006)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria hyuA6
    		 D-stereospecific phenylhydantoinase
    		 34(a)
    		 1 → many
    		 Chromosome(3008050-3009435)


    ENSEMBL Gene Tree for CRMP1 (if available)
    TreeFam Gene Tree for CRMP1 (if available) 

    Paralogs
    for CRMP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRMP1 gene
    DPYSL32  DPYSL52  DPYSL42  DPYS2  DPYSL22  
    5 SIMAP similar genes for CRMP1 using alignment to 4 protein entries:     DPYL1_HUMAN (see all proteins):
    DPYSL2    DPYSL3    DPYSL4    DPYSL5    DPYS

    CRMP1 for paralogs           About GeneDecksing



    Genomic Variants
    for CRMP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CRMP1
         1 CNV: 68641
         2 Indels: 62159 40596
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRMP1
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    Disorders / Diseases
    for CRMP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRMP1 for disorders           About GeneDecksing

    OMIM gene information: 602462    OMIM disorders: --

    14 diseases for CRMP1:    About MalaCards
    ellis-van creveld syndrome    dihydropyrimidinuria    macular degeneration    down syndrome
    huntington's disease    lung adenocarcinoma    lung cancer    adenocarcinoma
    ataxia    pneumonia    tuberculosis    leukemia
    neuronitis    mycobacterium tuberculosis

    3 Novoseek disease relationships for CRMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 33.9 3 11562390 (3)
    metastasis 16.9 4 11562390 (2), 12650609 (1), 14996858 (1)
    cancer 7.58 4 12650609 (2), 18524846 (1), 11562390 (1)

    Human Genome Epidemiology (HuGE) Navigator: CRMP1 (2 documents)

    Export disorders for CRMP1 gene to outside databases

    Publications
    for CRMP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRMP1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CRMP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)1, 2, 3, 9 Hamajima N.... Nonaka M. (1996)
    2. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PubMed id 11562390)1, 2, 9 Shih J.-Y.... Yang P.-C. (2001)
    3. Genomic organization and localization of the human CRMP-1 gene. (PubMed id 10048489)1, 2, 9 Torres R. and Polymeropoulos M.H. (1998)
    4. Long form collapsin response mediator protein-1 (LCRM P-1) expression is associated with clinical outcome and lymph node metastasis i n non-small cell lung cancer patients. (PubMed id 19362386)1, 2, 9 Pan S.H....Yang P.C. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. (PubMed id 18524846)1, 9 Wu C.C....Yang P.C. (2008)
    7. Loss of collapsin response mediator Protein1, as dete cted by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EG FRvIII. (PubMed id 19903856)1, 9 Mukherjee J....Guha A. (2009)
    8. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)1, 9 Sivakumaran T.A. and Lesperance M.M. (2004)
    9. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. (PubMed id 14996858)1, 9 Chang C.C....Kuo M.L. (2004)
    10. Collapsin response mediator protein-1: a novel invasion-suppressor gene. (PubMed id 12650609)1, 9 Shih J.Y....Yang P.C. (2003)

    External Searches for CRMP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRMP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1400 HGNC: 2365 AceView: CRMP1 Ensembl:ENSG00000072832 euGenes: HUgn1400
    ECgene: CRMP1 H-InvDB: CRMP1

    Other Databases showing CRMP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRMP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRMP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRMP1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CRMP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRMP1 gene:
    Search GeneIP for patents involving CRMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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