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CRMP1 Gene(Protein Coding)

Collapsin Response Mediator Protein 1

GCID:
GC04M005815
GIFtS:
57
Genes Participants
UDN Logo

Aliases for CRMP1 Gene

Aliases for CRMP1 Gene

  • Collapsin Response Mediator Protein 1 2 3 4 5
  • Unc-33-Like Phosphoprotein 3 3 4
  • CRMP-1 3 4
  • DPYSL1 3 4
  • ULIP-3 3 4
  • DRP-1 3 4
  • Dihydropyrimidinase-Related Protein 1 3
  • Dihydropyrimidinase-Like 1 3
  • ULIP3 4
  • DRP1 3

External Ids for CRMP1 Gene

Previous GeneCards Identifiers for CRMP1 Gene

  • GC04M005704
  • GC04P005871
  • GC04M005887
  • GC04M005940

Summaries for CRMP1 Gene

Entrez Gene Summary for CRMP1 Gene

  • This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRMP1 Gene

CRMP1 (Collapsin Response Mediator Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Semaphorin Signaling. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot for CRMP1 Gene

  • Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.

Gene Wiki entry for CRMP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRMP1 Gene

Genomics for CRMP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CRMP1 Gene

Enhancers for CRMP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G005889 1 Ensembl ENCODE 20.9 +2.4 2357 2.9 CTCF MXI1 SUZ12 ZSCAN4 MAX ETS1 GLIS2 POLR2A SCRT2 SMC3 CRMP1 GC04P005887 PIR36148
GH04G005886 0.8 ENCODE 21.9 +5.2 5153 2.0 CTCF KLF1 ZNF777 MXI1 KLF17 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 CRMP1 GC04P005887 PIR36148
GH04G005745 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +139.5 139547 15.4 SIN3A GATA2 ETV6 FOS CREM JUNB SMARCA4 GLIS1 NR2C1 MYC EVC CRMP1 EVC2 PIR43243 GC04P005776
GH04G005912 0.6 ENCODE 15.3 -19.7 -19678 0.6 BCL11A SCRT2 TEAD4 MAX POU5F1 ZNF266 CRMP1 MIR378D1
GH04G005883 0.4 ENCODE 20.5 +8.8 8782 1.2 ZNF316 MAFK CRMP1 GC04P005887 PIR36148 GC04P005872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRMP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CRMP1 gene promoter:

Genomic Location for CRMP1 Gene

Chromosome:
4
Start:
5,748,084 bp from pter
End:
5,893,083 bp from pter
Size:
145,000 bases
Orientation:
Minus strand

Genomic View for CRMP1 Gene

Genes around CRMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRMP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CRMP1 Gene

Proteins for CRMP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CRMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14194-DPYL1_HUMAN
    Recommended name:
    Dihydropyrimidinase-related protein 1
    Protein Accession:
    Q14194
    Secondary Accessions:
    • A0EJG6
    • Q13024
    • Q4W5F1
    • Q96TC8

    Protein attributes for CRMP1 Gene

    Size:
    572 amino acids
    Molecular mass:
    62184 Da
    Quaternary structure:
    • Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CRMP1 Gene

    Alternative splice isoforms for CRMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRMP1 Gene

Protein Expression for CRMP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CRMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRMP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CRMP1

No data available for DME Specific Peptides for CRMP1 Gene

Domains & Families for CRMP1 Gene

Protein Domains for CRMP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRMP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14194

UniProtKB/Swiss-Prot:

DPYL1_HUMAN :
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Family:
  • Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
genes like me logo Genes that share domains with CRMP1: view

No data available for Gene Families for CRMP1 Gene

Function for CRMP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CRMP1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.

Gene Ontology (GO) - Molecular Function for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383276
GO:0016787 hydrolase activity IEA --
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA --
GO:0031005 filamin binding IPI 25358863
genes like me logo Genes that share ontologies with CRMP1: view
genes like me logo Genes that share phenotypes with CRMP1: view

Animal Models for CRMP1 Gene

MGI Knock Outs for CRMP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRMP1

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRMP1 Gene

Localization for CRMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRMP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRMP1 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CRMP1: view

Pathways & Interactions for CRMP1 Gene

genes like me logo Genes that share pathways with CRMP1: view

Pathways by source for CRMP1 Gene

SIGNOR curated interactions for CRMP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 8973361
GO:0007399 nervous system development IEA,TAS 8973361
GO:0007411 axon guidance IEA --
GO:0010977 negative regulation of neuron projection development IGI 25358863
genes like me logo Genes that share ontologies with CRMP1: view

Drugs & Compounds for CRMP1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CRMP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CRMP1 Gene

(4) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(379) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRMP1 Gene

Collapsin response mediator protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CRMP1 Gene

GeneLoc Exon Structure for
CRMP1
ECgene alternative splicing isoforms for
CRMP1

Expression for CRMP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRMP1 Gene

mRNA expression in normal human tissues for CRMP1 Gene
mRNA expression by BioGPS for CRMP1 GenemRNA expression by GTEx for CRMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRMP1 Gene

This gene is overexpressed in Fetal Brain (37.3), Brain (11.3), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRMP1 Gene



Protein tissue co-expression partners for CRMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRMP1 Gene:

CRMP1

SOURCE GeneReport for Unigene cluster for CRMP1 Gene:

Hs.135270

mRNA Expression by UniProt/SwissProt for CRMP1 Gene:

Q14194-DPYL1_HUMAN
Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for CRMP1 Gene

  • Nervous system(5)
  • Eye(4.6)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with CRMP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRMP1 Gene

Orthologs for CRMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CRMP1 34 35
  • 99.51 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CRMP1 35
  • 95 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CRMP1 35
  • 93 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CRMP1 34 35
  • 91.59 (n)
dog
(Canis familiaris)
 Mammalia CRMP1 34 35
  • 91.16 (n)
mouse
(Mus musculus)
 Mammalia Crmp1 34 16 35
  • 89.26 (n)
rat
(Rattus norvegicus)
 Mammalia Crmp1 34
  • 88.13 (n)
chicken
(Gallus gallus)
 Aves CRMP1B 35
  • 87 (a)
 OneToOne
CRMP1 34
  • 81.75 (n)
lizard
(Anolis carolinensis)
 Reptilia CRMP1 35
  • 85 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia crmp1 34
  • 75.11 (n)
zebrafish
(Danio rerio)
 Actinopterygii crmp1 34 35
  • 72.87 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CRMP 36
  • 45 (a)
worm
(Caenorhabditis elegans)
 Secernentea dhp-2 36
  • 48 (a)
dhp-1 36
  • 46 (a)
unc-33 36
  • 32 (a)
Species where no ortholog for CRMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRMP1 Gene

ENSEMBL:
Gene Tree for CRMP1 (if available)
TreeFam:
Gene Tree for CRMP1 (if available)

Paralogs for CRMP1 Gene

Paralogs for CRMP1 Gene

(5) SIMAP similar genes for CRMP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRMP1: view

Variants for CRMP1 Gene

Sequence variations from dbSNP and Humsavar for CRMP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000009226 -- 5,882,290(+) TTTCT(C/T)CTCCT intron-variant
rs10000356 -- 5,885,083(+) CTTCC(A/G)TCTCT intron-variant
rs1000110327 -- 5,828,221(+) GGTAA(G/T)CGTCC intron-variant
rs1000148603 -- 5,825,136(+) AAATG(G/T)CAGCT intron-variant
rs1000158533 -- 5,887,060(+) GTTCC(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRMP1 Gene

Variant ID Type Subtype PubMed ID
dgv2923e59 CNV duplication 20981092
dgv311e215 CNV deletion 23714750
esv2279377 CNV deletion 18987734
esv2678074 CNV deletion 23128226
esv2726978 CNV deletion 23290073
esv2726979 CNV deletion 23290073
esv29375 CNV gain+loss 19812545
esv34196 OTHER inversion 12058347
esv7115 CNV loss 19470904
nsv1073298 CNV deletion 25765185
nsv1125797 CNV tandem duplication 24896259
nsv1126678 CNV deletion 24896259
nsv1153630 CNV insertion 26484159
nsv293630 CNV deletion 16902084
nsv822449 CNV gain 20364138
nsv829844 CNV gain 17160897
nsv829845 CNV loss 17160897
nsv949775 CNV deletion 24416366
nsv954403 CNV deletion 24416366

Variation tolerance for CRMP1 Gene

Residual Variation Intolerance Score: 8.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.40; 77.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRMP1 Gene

Human Gene Mutation Database (HGMD)
CRMP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRMP1 Gene

Disorders for CRMP1 Gene

Relevant External Links for CRMP1

Genetic Association Database (GAD)
CRMP1
Human Genome Epidemiology (HuGE) Navigator
CRMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRMP1

No disorders were found for CRMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRMP1 Gene

Publications for CRMP1 Gene

  1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PMID: 8973361) Hamajima N. … Nonaka M. (Gene 1996) 2 3 4 22 64
  2. Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non- small cell lung cancer patients. (PMID: 19362386) Pan S.-H. … Yang P.-C. (Lung Cancer 2010) 3 4 22 64
  3. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PMID: 11562390) Shih J.-Y. … Yang P.-C. (J. Natl. Cancer Inst. 2001) 3 4 22 64
  4. Genomic organization and localization of the human CRMP-1 gene. (PMID: 10048489) Torres R. … Polymeropoulos M.H. (DNA Res. 1998) 3 4 22 64
  5. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PMID: 20087401) Ingersoll R.G. … Beaty T.H. (Eur. J. Hum. Genet. 2010) 3 46 64

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