CRMP1 Gene

Aliases
for CRMP1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC04M005704 GC04P005871 GC04M005887 GC04M005940

Summaries
for CRMP1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for CRMP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NT_006051.19  NC_018915.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRMP1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRMP1

CRMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M005815:  view genomic region     (about GC identifiers)

Proteins
for CRMP1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

1 PDB 3D structure from and Proteopedia for CRMP1:

4B3Z (3D)    

Explore the universe of human proteins at neXtProt for CRMP1: NX_Q14194

Explore proteomics data for CRMP1 at MOPED

Post-translational modifications: 

CRMP1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CRMP1 OriGene Protein Over-expression Lysate for CRMP1 OriGene MassSpec for CRMP1 OriGene Custom Protein Services for CRMP1
	GenScript Custom Purified and Recombinant Proteins Services for CRMP1
	Novus Biologicals CRMP1 Proteins Novus Biologicals CRMP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CRMP1
	Cloud-Clone Corp. Proteins for CRMP1
	Search eBioscience for Proteins for CRMP1
	Search GeneTex for Proteins for CRMP1
	antibodies-online proteins for CRMP1 (12 products)
	antibodies-online peptides for CRMP1

CRMP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CRMP1
	Browse R&D Systems for Antibodies
	OriGene Antibodies for CRMP1 OriGene Custom Antibody Services for CRMP1
	Novus Biologicals CRMP1 Antibodies
	Abcam antibodies for CRMP1
	Cloud-Clone Corp. Antibodies for CRMP1
	ThermoFisher Antibodies for CRMP1
	antibodies-online antibodies for CRMP1 (90 products)

CRMP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CRMP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRMP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CRMP1 Cloud-Clone Corp. CLIAs for CRMP1
	Search eBioscience for ELISAs for CRMP1
	antibodies-online kits for CRMP1 (6 products)

Domains /
Families
for CRMP1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q14194

Find genes that share domains with CRMP1           About GenesLikeMe

Function
for CRMP1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): 4 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for Crmp1)

genOway: Develop your customized and physiologically relevant rodent model for CRMP1

miRNA Products:		Block miRNA regulation of human, mouse, rat CRMP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CRMP1 (see all 26):
		hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*
		SwitchGear 3'UTR luciferase reporter plasmid: CRMP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CRMP1
		Predesigned siRNA for gene silencing in human, mouse, rat CRMP1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CRMP1

Clone Products:		OriGene clones in human, mouse for CRMP1 (see all 13) OriGene ORF clones in mouse, rat for CRMP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRMP1 (NM_001313)
		Sino Biological Human cDNA Clone for CRMP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRMP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for CRMP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

Localization
for CRMP1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	5
cytosol	4
nucleus	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

Pathways & Interactions
for CRMP1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CRMP1 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	L1CAM interactions	Axon guidance 0.63 Developmental Biology 0.63
2	Semaphorin interactions	Semaphorin interactions 0.43 CRMPs in Sema3A signaling 0.00
3	Semaphorin Signaling	Semaphorin Signaling
4	Guidance Cues and Growth Cone Motility	Guidance Cues and Growth Cone Motility

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRMP1

	Guidance Cues and Growth Cone Motility
	Semaphorin Signaling

1 Reactome Pathway for CRMP1

CRMPs in Sema3A signaling

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for CRMP1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for CRMP1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for CRMP1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Brain (Nervous System)    fully expand to see all 3 entries
Endothelial Cells Blood Brain Barrier
Cerebral Cortex
Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
Hindgut
Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
PureStem 4D20.8, NCr-fac Progenitor
Heart (Cardiovascular System)    fully expand to see all 2 entries
Cushion Mesenchymal Cells Endocardium
Endothelium (Cardiovascular System)    fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier

Primer Products:		OriGene qPCR primer pairs and template standards for CRMP1 OriGene qSTAR qPCR primer pairs in human, mouse for CRMP1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRMP1
		QuantiTect SYBR Green Assays in human, mouse, rat CRMP1
		QuantiFast Probe-based Assays in human, mouse, rat CRMP1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

Orthologs
for CRMP1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for CRMP1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for CRMP1 gene

DPYSL3²  DPYSL4²  DPYSL5²  DPYS²  DPYSL2²  

5 SIMAP similar genes for CRMP1 using alignment to 4 protein entries:     DPYL1_HUMAN (see all proteins):

DPYSL2    DPYSL3    DPYSL4    DPYSL5    DPYS

Find genes that share paralogs with CRMP1           About GenesLikeMe

Genomic Variants
for CRMP1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for CRMP1 (see all 1992)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs106081221,2	C	--	5812050(+)	AAAAA-/A/A       A/AAAGAGAT	2	--	int1		1		NA	2
rs1833140501,2		--	5822022(+)	ATCATA/CACCAT	2	--	ds5001		0	--	--	--	--
rs1481650341,2	C	--	5822074(+)	TTACT-/AACAACAG	2	--	ds5001		0	--	--	--	--
rs38365521,2	C	--	5822075(+)	TAACA-/ACAGCTAA	2	--	ds5001		0	--	--	--	--
rs1465932091,2	C	--	5822119(+)	TTATCC/TGTCCT	2	--	ds5001		0	--	--	--	--
rs1892167121,2		--	5822169(+)	GTGAAC/GTTTAG	2	--	ds5001		0	--	--	--	--
rs1151455161,2	C	--	5822257(+)	AATCAA/GTGCAA	2	--	ds5001		0	--	--	--	--
rs1498499811,2		--	5822274(+)	AGCCTA/GTTTTG	2	--	ds5001		0	--	--	--	--
rs1145703481,2	F	--	5822443(+)	CACGCG/AGGGGG	2	--	ds5001		1		WA	118
rs1488186311,2	C	--	5822460(+)	AAGCAG/TTCGTA	2	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRMP1 (5749811 - 5894785 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CRMP1 (see all 11):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2678074	CNV	Deletion	23128226
esv2726979	CNV	Deletion	23290073
esv2726978	CNV	Deletion	23290073
esv2279377	CNV	Deletion	18987734
nsv293630	CNV	Loss	16902084
nsv829845	CNV	Loss	17160897
esv7115	CNV	Loss	19470904
nsv822449	CNV	Gain	20364138
nsv829844	CNV	Gain	17160897
esv29375	CNV	Gain+Loss	19812545

Human Gene Mutation Database (HGMD): CRMP1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CRMP1

DNA2.0 Custom Variant and Variant Library Synthesis for CRMP1

Disorders / Diseases
for CRMP1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

3 Novoseek inferred disease relationships for CRMP1 gene    About this table

Publications
for CRMP1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)^{1, 2, 3, 9} Hamajima N.... Nonaka M. (Gene 1996)
2. Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PubMed id 11562390)^{1, 2, 9} Shih J.-Y.... Yang P.-C. (J. Natl. Cancer Inst. 2001)
3. Genomic organization and localization of the human CRMP-1 gene. (PubMed id 10048489)^{1, 2, 9} Torres R. and Polymeropoulos M.H. (DNA Res. 1998)
4. Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non- small cell lung cancer patients. (PubMed id 19362386)^{1, 2, 9} Pan S.-H.... Yang P.-C. (Lung Cancer 2010)
5. Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PubMed id 20087401)^{1, 4} Ingersoll R.G....Beaty T.H. (Eur. J. Hum. Genet. 2010)
6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
8. Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. (PubMed id 18524846)^{1, 9} Wu C.C....Yang P.C. (Mol. Cancer Ther. 2008)
9. Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII. (PubMed id 19903856)^{1, 9} Mukherjee J....Guha A. (Cancer Res. 2009)
10. Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)^{1, 9} Sivakumaran T.A. and Lesperance M.M. (Int. J. Mol. Med. 2004)

External Searches for CRMP1 gene

Genome Databases showing CRMP1 gene

Other Databases showing CRMP1 gene

Specialized Databases showing CRMP1 gene

Products
for CRMP1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section