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CRMP1 Gene

protein-coding GIFtS: 64
GCID: GC04M005815

Collapsin Response Mediator Protein 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Collapsin Response Mediator Protein 1¹ ² ³		ULIP-3² ³
DPYSL1² ³ ⁵		DRP1² ⁵
Unc-33-Like Phosphoprotein 3² ³		Dihydropyrimidinase-Like 1²
CRMP-1² ³		Dihydropyrimidinase-Related Protein 1²
DRP-1² ³		ULIP3³

External Ids:	HGNC: 2365¹	Entrez Gene: 1400²	Ensembl: ENSG00000072832⁷	OMIM: 602462⁵	UniProtKB: Q14194³

Export aliases for CRMP1 gene to outside databases

Previous GC identifers: GC04M005704 GC04P005871 GC04M005887 GC04M005940

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRMP1 Gene:

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system.

The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in

semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRMP1 Gene:

CRMP1 (collapsin response mediator protein 1) is a protein-coding gene. Diseases associated with CRMP1 include ellis-van creveld syndrome, and lung adenocarcinoma. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is DPYSL3.

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194

Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a

role in axon guidance, invasive growth and cell migration. May participate in cytokinesis

Gene Wiki entry for CRMP1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000004.12 NT_006051.19 NC_018915.2

Regulatory elements:

Regulatory transcription factor binding sites in the CRMP1 gene promoter:
NRSF form 1 MyoD NRSF form 2 Tal-1beta E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRMP1 promoter sequence

Search Chromatin IP Primers for CRMP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRMP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.2 HGNC cytogenetic band: 4p16.1

CRMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRMP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M005815: view genomic region (about GC identifiers)

Start:	5,749,811 bp from pter	End:	5,894,785 bp from pter
Size:	144,975 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194 (See protein sequence)

Recommended Name: Dihydropyrimidinase-related protein 1

Size: 572 amino acids; 62184 Da

Subunit: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By

similarity)

Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for

dihydropyrimidinase activity. Its enzyme activity is therefore unsure

1 PDB 3D structure from and Proteopedia for CRMP1:

4B3Z (3D)

Secondary accessions: A0EJG6 Q13024 Q4W5F1 Q96TC8

Alternative splicing: 2 isoforms: Q14194-1 Q14194-2

Explore the universe of human proteins at neXtProt for CRMP1: NX_Q14194

Explore proteomics data for CRMP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See CRMP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001014809.1 NP_001275590.1 NP_001275591.1 NP_001304.1

ENSEMBL proteins:

ENSP00000321606 ENSP00000380987 ENSP00000425742

Reactome Protein details: Q14194

CRMP1 Human Recombinant Protein Products:

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	Novus Biologicals CRMP1 Proteins Novus Biologicals CRMP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CRMP1
	Cloud-Clone Corp. Proteins for CRMP1

CRMP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CRMP1
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	Novus Biologicals CRMP1 Antibodies
	Abcam antibodies for CRMP1
	Cloud-Clone Corp. Antibodies for CRMP1
	ThermoFisher Antibodies for CRMP1
	LSBio Antibodies in human, mouse, rat for CRMP1

CRMP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CRMP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRMP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CRMP1 Cloud-Clone Corp. CLIAs for CRMP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR011778 Hydantoinase/dihydroPyrase

IPR011059 Metal-dep_hydrolase_composite

IPR006680 Amidohydro_1

Graphical View of Domain Structure for InterPro Entry Q14194

ProtoNet protein and cluster: Q14194

2 Blocks protein domains:

IPB005847 Dihydroorotase region

IPB011550 Amidohydrolase-like

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily

CRMP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DPYL1_HUMAN, Q14194

Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a

role in axon guidance, invasive growth and cell migration. May participate in cytokinesis

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15383276
GO:0016787	hydrolase activity	--	--
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	--	--
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IEA	--

CRMP1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CRMP1:

Increased cell number in G1, s

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crmp1):

behavior/neurological

cellular

nervous system

CRMP1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Crmp1^tm1.1Swl for CRMP1

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRMP1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRMP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRMP1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRMP1

miRNA Products:		Block miRNA regulation of human, mouse, rat CRMP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CRMP1 (see all 26):
		hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*

		SwitchGear 3'UTR luciferase reporter plasmid: CRMP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CRMP1
		Predesigned siRNA for gene silencing in human, mouse, rat CRMP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CRMP1

Clone Products:		OriGene clones in human, mouse for CRMP1 (see all 13) OriGene ORF clones in mouse, rat for CRMP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRMP1 (NM_001313)
		Sino Biological Human cDNA Clone for CRMP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRMP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for CRMP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DPYL1_HUMAN, Q14194: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm,

cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
cytosol	4
nucleus	1
peroxisome	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005815	microtubule organizing center	IEA	--
GO:0005819	spindle	IEA	--
GO:0005829	cytosol	TAS	--
GO:0030425	dendrite	IEA	--

CRMP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CRMP1 About

See pathways by source

SuperPath

Contained pathways About

L1CAM interactions

Axon guidance

0.63

Developmental Biology

0.63

Semaphorin interactions

Semaphorin interactions

0.43

CRMPs in Sema3A signaling

0.00

Semaphorin Signaling

Semaphorin Signaling

Guidance Cues and Growth Cone Motility

Guidance Cues and Growth Cone Motility

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRMP1

	Guidance Cues and Growth Cone Motility
	Semaphorin Signaling

1 Reactome Pathway for CRMP1

CRMPs in Sema3A signaling

CRMP1 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CRMP1
Interactions:

GeneGlobe Interaction Network for CRMP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CRMP1 (Q14194^{1, 2, 3} ENSP00000321606⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 130)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXIN1	O15169¹^,²^,³	EBI-473101,EBI-710484 MINT-64312 I2D: score=4
ENSG00000172850	Q9Y333²^,³	MINT-65810 I2D: score=4
ENSG00000224979	Q9Y333²^,³	MINT-65810 I2D: score=4
ENSG00000225998	Q9Y333²^,³	MINT-65810 I2D: score=4
ENSG00000231502	Q9Y333²^,³	MINT-65810 I2D: score=4

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	TAS	8973361
GO:0006208	pyrimidine nucleobase catabolic process	IEA	--
GO:0007399	nervous system development	TAS	8973361
GO:0007411	axon guidance	TAS	--
GO:0048666	neuron development	--	--

CRMP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CRMP1 (DPYL1)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CRMP1 gene (4 alternative transcripts):

NM_001014809.2 NM_001288661.1 NM_001288662.1 NM_001313.4

Unigene Cluster for CRMP1:

Collapsin response mediator protein 1

Hs.135270 [show with all ESTs]

Unigene Representative Sequence: NM_001014809

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506216 ENST00000324989(uc003gis.3) ENST00000397890(uc003giq.3)

ENST00000513911 ENST00000511535 ENST00000512574(uc003gir.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat CRMP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CRMP1 (see all 26):
		hsa-miR-448 hsa-miR-362-3p hsa-miR-520d-5p hsa-miR-4318 hsa-miR-200a hsa-let-7a-2* hsa-miR-624* hsa-miR-888*

		SwitchGear 3'UTR luciferase reporter plasmid: CRMP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CRMP1
		Predesigned siRNA for gene silencing in human, mouse, rat CRMP1

Clone Products:		OriGene clones in human, mouse for CRMP1 (see all 13) OriGene ORF clones in mouse, rat for CRMP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRMP1 (NM_001313)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRMP1

Primer Products:		OriGene qPCR primer pairs and template standards for CRMP1 OriGene qSTAR qPCR primer pairs in human, mouse for CRMP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CRMP1
		QuantiTect SYBR Green Assays in human, mouse, rat CRMP1
		QuantiFast Probe-based Assays in human, mouse, rat CRMP1

Additional mRNA sequence:

AK091696.1 AK094725.1 AK122754.1 AK127754.1 AK309379.1 BC000252.1 BC007613.1 BC007898.2

BT006806.1 D78012.1 DQ206871.1 U17278.1

20 DOTS entries:

DT.100762743 DT.100821208 DT.101983853 DT.100821182 DT.219724 DT.95087464 DT.100802877 DT.121270089

DT.100821181 DT.100821207 DT.121270099 DT.100821189 DT.100821214 DT.95087523 DT.100652789 DT.121270015

DT.121270062 DT.92448235 DT.102835332 DT.219725

Selected AceView cDNA sequences (see all 379):

AW732221 AW162899 AA333470 AK094725 Z42153 BM697311 BM893586 BC007613

AI357768 BM698495 AW583553 BM984316 AA873063 BE019357 BU687205 CR622220

AI299048 T32217 BG055997 T31787 AI268591 AA948277 NM_001313 AA450245

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRMP1 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16a	·	16b	·	16c
SP1:					-		-		-										-																				-				-
SP2:																			-																				-				-
SP3:													-		-		-		-
SP4:													-						-
SP5:					-		-		-

ECgene alternative splicing isoforms for CRMP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CRMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

CRMP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 8) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Endothelial Cells Blood Brain Barrier
Cerebral Cortex

Gut Tube (Gastrointestinal Tract) fully expand to see all 3 entries
Hindgut

Neural Crest (Gastrulation Derivatives) fully expand to see all 2 entries
PureStem 4D20.8, NCr-fac Progenitor

Heart (Cardiovascular System) fully expand to see all 2 entries
Cushion Mesenchymal Cells Endocardium

Endothelium (Cardiovascular System) fully expand to see all 2 entries
Endothelial Cells Blood Brain Barrier

CRMP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CRMP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.135270

UniProtKB/Swiss-Prot: DPYL1_HUMAN, Q14194

Tissue specificity: Brain

Custom PCR Arrays for CRMP1

Primer Products:		OriGene qPCR primer pairs and template standards for CRMP1 OriGene qSTAR qPCR primer pairs in human, mouse for CRMP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CRMP1
		QuantiTect SYBR Green Assays in human, mouse, rat CRMP1
		QuantiFast Probe-based Assays in human, mouse, rat CRMP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRMP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CRMP1 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crmp1^{1 , 5}	collapsin response mediator protein 1^{1, 5}	89.26(n)¹ 96.5(a)¹		5 (19.96 cM)⁵ 12933¹ NM_001136058.2¹ NP_001129530.1¹ 37242080⁵
chicken (Gallus gallus)	Aves	CRMP1¹	collapsin response mediator protein 1	81.75(n) 93.74(a)		395156 NM_204495.1 NP_989826.1
lizard (Anolis carolinensis)	Reptilia	CRMP1⁶	collapsin response mediator protein 1	85(a)	1 ↔ 1	5(80502695-80553498)
tropical clawed frog (Xenopus tropicalis)	Amphibia	crmp1¹	collapsin response mediator protein 1	75.11(n) 84.83(a)		779767 NM_001078846.1 NP_001072314.1
zebrafish (Danio rerio)	Actinopterygii	crmp1¹	collapsin response mediator protein 1	72.87(n) 79.61(a)		553756 NM_001020725.1 NP_001018561.1

ENSEMBL Gene Tree for CRMP1 (if available)
TreeFam Gene Tree for CRMP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CRMP1 gene

DPYSL3² DPYSL4² DPYSL5² DPYS² DPYSL2²

5 SIMAP similar genes for CRMP1 using alignment to 4 protein entries: DPYL1_HUMAN (see all proteins):

DPYSL2 DPYSL3 DPYSL4 DPYSL5 DPYS

CRMP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10608122^1,2	C	--	5812050(+)	`AAAAA-/A/A A/AAAGAGAT`	2	--	int¹		1		NA	2
rs183314050^1,2		--	5822022(+)	`ATCATA/CACCAT`	2	--	ds500¹		0	--	--	--	--
rs148165034^1,2	C	--	5822074(+)	`TTACT-/AACAACAG`	2	--	ds500¹		0	--	--	--	--
rs3836552^1,2	C	--	5822075(+)	`TAACA-/ACAGCTAA`	2	--	ds500¹		0	--	--	--	--
rs146593209^1,2	C	--	5822119(+)	`TTATCC/TGTCCT`	2	--	ds500¹		0	--	--	--	--
rs189216712^1,2		--	5822169(+)	`GTGAAC/GTTTAG`	2	--	ds500¹		0	--	--	--	--
rs115145516^1,2	C	--	5822257(+)	`AATCAA/GTGCAA`	2	--	ds500¹		0	--	--	--	--
rs149849981^1,2		--	5822274(+)	`AGCCTA/GTTTTG`	2	--	ds500¹		0	--	--	--	--
rs114570348^1,2	F	--	5822443(+)	`CACGCG/AGGGGG`	2	--	ds500¹		1		WA	118
rs148818631^1,2	C	--	5822460(+)	`AAGCAG/TTCGTA`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRMP1 (5749811 - 5894785 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for CRMP1 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
esv2678074	CNV	Deletion	23128226
esv2726979	CNV	Deletion	23290073
esv2726978	CNV	Deletion	23290073
esv2279377	CNV	Deletion	18987734
nsv293630	CNV	Loss	16902084
nsv829845	CNV	Loss	17160897
esv7115	CNV	Loss	19470904
nsv822449	CNV	Gain	20364138
nsv829844	CNV	Gain	17160897
esv29375	CNV	Gain+Loss	19812545

Human Gene Mutation Database (HGMD): CRMP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602462 OMIM disorders: --

14 diseases for CRMP1:
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ellis-van creveld syndrome lung adenocarcinoma down syndrome ataxia

huntington's disease type 1 diabetes tuberculosis adenocarcinoma

cervicitis lung cancer schizophrenia neuronitis

leukemia endotheliitis

CRMP1 for disorders About GeneDecksing

3 Novoseek inferred disease relationships for CRMP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer lung	33.9	3	11562390 (3)
metastasis	16.9	4	11562390 (2), 12650609 (1), 14996858 (1)
cancer	7.58	4	12650609 (2), 18524846 (1), 11562390 (1)

Genetic Association Database (GAD): CRMP1
Human Genome Epidemiology (HuGE) Navigator: CRMP1 (2 documents)

Export disorders for CRMP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRMP1 gene, integrated from 10 sources (see all 46):
(articles sorted by number of sources associating them with CRMP1)

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A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. (PubMed id 8973361)^{1, 2, 3, 9} Hamajima N.... Nonaka M. (Gene 1996)
Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells. (PubMed id 11562390)^{1, 2, 9} Shih J.-Y.... Yang P.-C. (J. Natl. Cancer Inst. 2001)
Genomic organization and localization of the human CRMP-1 gene. (PubMed id 10048489)^{1, 2, 9} Torres R. and Polymeropoulos M.H. (DNA Res. 1998)
Long form collapsin response mediator protein-1 (LCRMP-1) expression is associated with clinical outcome and lymph node metastasis in non- small cell lung cancer patients. (PubMed id 19362386)^{1, 2, 9} Pan S.-H.... Yang P.-C. (Lung Cancer 2010)
Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. (PubMed id 20087401)^{1, 4} Ingersoll R.G....Beaty T.H. (Eur. J. Hum. Genet. 2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. (PubMed id 18524846)^{1, 9} Wu C.C....Yang P.C. (Mol. Cancer Ther. 2008)
Loss of collapsin response mediator Protein1, as detected by iTRAQ analysis, promotes invasion of human gliomas expressing mutant EGFRvIII. (PubMed id 19903856)^{1, 9} Mukherjee J....Guha A. (Cancer Res. 2009)
Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. (PubMed id 15492864)^{1, 9} Sivakumaran T.A. and Lesperance M.M. (Int. J. Mol. Med. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1400	HGNC: 2365	AceView: CRMP1	Ensembl:ENSG00000072832	euGenes: HUgn1400
ECgene: CRMP1	H-InvDB: CRMP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRMP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CRMP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CRMP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CRMP1 gene:
Search GeneIP for patents involving CRMP1

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Collapsin Response Mediator Protein 1

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Collapsin Response Mediator Protein 1

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