Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRLS1 Gene

Aliases for CRLS1 Gene

  • Cardiolipin Synthase 1 2 3
  • C20orf155 3 4 6
  • GCD10 3 6
  • CLS1 3 4
  • CLS 3 4
  • Chromosome 20 Open Reading Frame 155 2
  • Cardiolipin Synthase (CMP-Forming) 3
  • GCD10 Homolog (S. Cerevisiae) 2
  • Protein GCD10 Homolog 4
  • EC 2.7.8.41 4
  • DJ967N21.6 3

External Ids for CRLS1 Gene

Previous Symbols for CRLS1 Gene

  • C20orf155

Summaries for CRLS1 Gene

GeneCards Summary for CRLS1 Gene

CRLS1 (Cardiolipin Synthase 1) is a Protein Coding gene. Diseases associated with CRLS1 include catastrophic antiphospholipid syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups.

UniProtKB/Swiss-Prot for CRLS1 Gene

  • Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRLS1 Gene

Genomics for CRLS1 Gene

Genomic Location for CRLS1 Gene

Start:
6,006,089 bp from pter
End:
6,040,072 bp from pter
Size:
33,984 bases
Orientation:
Plus strand

Genomic View for CRLS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRLS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRLS1 Gene

Regulatory Elements for CRLS1 Gene

Proteins for CRLS1 Gene

  • Protein details for CRLS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJA2-CRLS1_HUMAN
    Recommended name:
    Cardiolipin synthase (CMP-forming)
    Protein Accession:
    Q9UJA2
    Secondary Accessions:
    • D3DW09
    • E9PAT4
    • Q27RP0
    • Q69YQ5

    Protein attributes for CRLS1 Gene

    Size:
    301 amino acids
    Molecular mass:
    32593 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRLS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRLS1 Gene

Proteomics data for CRLS1 Gene at MOPED

Post-translational modifications for CRLS1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys225

Other Protein References for CRLS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRLS1 Gene

Domains for CRLS1 Gene

Protein Domains for CRLS1 Gene

UniProtKB/Swiss-Prot:

CRLS1_HUMAN
Family:
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.:
    • Q9UJA2
genes like me logo Genes that share domains with CRLS1: view

No data available for Gene Families for CRLS1 Gene

Function for CRLS1 Gene

Molecular function for CRLS1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 8.2. {ECO:0000269 PubMed:16678169};
UniProtKB/Swiss-Prot CatalyticActivity: A CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP.
UniProtKB/Swiss-Prot Function: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

Enzyme Numbers (IUBMB) for CRLS1 Gene

Gene Ontology (GO) - Molecular Function for CRLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups IEA --
genes like me logo Genes that share ontologies with CRLS1: view

miRNA for CRLS1 Gene

miRTarBase miRNAs that target CRLS1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRLS1 Gene

Localization for CRLS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRLS1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRLS1 Gene COMPARTMENTS Subcellular localization image for CRLS1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRLS1: view

Pathways for CRLS1 Gene

genes like me logo Genes that share pathways with CRLS1: view

Gene Ontology (GO) - Biological Process for CRLS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0008654 phospholipid biosynthetic process --
GO:0032049 cardiolipin biosynthetic process TAS --
GO:0036148 phosphatidylglycerol acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CRLS1: view

Compounds for CRLS1 Gene

(94) HMDB Compounds for CRLS1 Gene

Compound Synonyms Cas Number PubMed IDs
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:1(11Z))
  • Cardiolipins(72:4)
Not Available
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:2(9Z,12Z))
  • Cardiolipins(72:4)
Not Available
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(9Z))
  • Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9)
Not Available
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:2(9Z,12Z))
  • Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9)
Not Available
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:0)
  • Cardiolipins(72:5)
Not Available

(2) Novoseek inferred chemical compound relationships for CRLS1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylglycerophosphate 93.8 2
cardiolipin 87.5 15
genes like me logo Genes that share compounds with CRLS1: view

Transcripts for CRLS1 Gene

Unigene Clusters for CRLS1 Gene

Cardiolipin synthase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRLS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: -
SP11: - - - - - -

Relevant External Links for CRLS1 Gene

GeneLoc Exon Structure for
CRLS1
ECgene alternative splicing isoforms for
CRLS1

Expression for CRLS1 Gene

mRNA expression in normal human tissues for CRLS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRLS1 Gene

SOURCE GeneReport for Unigene cluster for CRLS1 Gene Hs.743956

mRNA Expression by UniProt/SwissProt for CRLS1 Gene

Q9UJA2-CRLS1_HUMAN
Tissue specificity: Highly expressed in tissues such as heart, skeletal muscle and liver.
genes like me logo Genes that share expressions with CRLS1: view

Orthologs for CRLS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CRLS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRLS1 36
  • 99.56 (n)
  • 100 (a)
CRLS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRLS1 36
  • 89.33 (n)
  • 88.33 (a)
CRLS1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRLS1 36
  • 90.33 (n)
  • 90 (a)
CRLS1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crls1 36
  • 86.11 (n)
  • 85.67 (a)
Crls1 16
Crls1 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRLS1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRLS1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crls1 36
  • 86.22 (n)
  • 85.67 (a)
chicken
(Gallus gallus)
Aves CRLS1 36
  • 79.9 (n)
  • 84.42 (a)
CRLS1 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRLS1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21707 36
tropical clawed frog
(Silurana tropicalis)
Amphibia crls1 36
  • 72.97 (n)
  • 81.09 (a)
Str.1917 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.666 36
zebrafish
(Danio rerio)
Actinopterygii crls1 36
  • 69.15 (n)
  • 76.62 (a)
crls1 37
  • 50 (a)
OneToOne
Dr.18235 36
fruit fly
(Drosophila melanogaster)
Insecta CLS 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crls-1 36
  • 54.88 (n)
  • 48.07 (a)
crls-1 37
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRD1 37
  • 27 (a)
OneToOne
CRD1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for CRLS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRLS1 Gene

ENSEMBL:
Gene Tree for CRLS1 (if available)
TreeFam:
Gene Tree for CRLS1 (if available)

Paralogs for CRLS1 Gene

No data available for Paralogs for CRLS1 Gene

Variants for CRLS1 Gene

Sequence variations from dbSNP and Humsavar for CRLS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1013184 -- 6,030,122(+) TCAGG(C/T)TTTTT intron-variant
rs1028410 -- 6,028,528(+) GTTAA(A/G)TTTAC intron-variant
rs1042968 -- 6,009,886(-) AGCAA(A/G)AACTC missense, reference
rs2143636 -- 6,021,391(+) ttatg(C/T)tgtta intron-variant
rs2143637 -- 6,021,509(+) gtggg(C/T)tctta intron-variant

Relevant External Links for CRLS1 Gene

HapMap Linkage Disequilibrium report
CRLS1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CRLS1 Gene

Disorders for CRLS1 Gene

(1) University of Copenhagen DISEASES for CRLS1 Gene

Relevant External Links for CRLS1

Genetic Association Database (GAD)
CRLS1
Human Genome Epidemiology (HuGE) Navigator
CRLS1
genes like me logo Genes that share disorders with CRLS1: view

No data available for UniProtKB/Swiss-Prot for CRLS1 Gene

Publications for CRLS1 Gene

  1. Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1). (PMID: 16547353) Lu B. … Feingold K.R. (J. Lipid Res. 2006) 2 3 4 23
  2. Identification and characterization of human cardiolipin synthase. (PMID: 16678169) Houtkooper R.H. … Vaz F.M. (FEBS Lett. 2006) 3 4 23
  3. Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria. (PMID: 16716149) Chen D. … Shi Y. (Biochem. J. 2006) 3 23
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for CRLS1 Gene

Sources for CRLS1 Gene

Back to Top

Content