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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRLS1 Gene

protein-coding   GIFtS: 55
GCID: GC20P005986

Cardiolipin Synthase 1

(Previous name: chromosome 20 open reading frame 155)
(Previous symbol: C20orf155)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cardiolipin Synthase 11 2     GCD10 Homolog (S. Cerevisiae)1
C20orf1551 2 3 5     Cardiolipin Synthase2
CLS2 3     dJ967N21.62
CLS12 3     EC 2.7.8.-3
GCD102 5     Protein GCD10 Homolog3
Chromosome 20 Open Reading Frame 1551     

External Ids:    HGNC: 161481   Entrez Gene: 546752   Ensembl: ENSG000000887667   OMIM: 6081885   UniProtKB: Q9UJA23   

Export aliases for CRLS1 gene to outside databases

Previous GC identifers: GC20P005935 GC20P005936 GC20P005943


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CRLS1 Gene: 
CRLS1 (cardiolipin synthase 1) is a protein-coding gene. Diseases associated with CRLS1 include catastrophic antiphospholipid syndrome, and antiphospholipid syndrome, and among its related super-pathways are Glycerophospholipid biosynthesis and Metabolic pathways. GO annotations related to this gene include phosphotransferase activity, for other substituted phosphate groups.

UniProtKB/Swiss-Prot: CRLS1_HUMAN, Q9UJA2
Function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another
to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRLS1 gene promoter:
         AhR   COMP1   FOXD3   Nkx2-5   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRLS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRLS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRLS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13-p12.3   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p13-p12.3

CRLS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRLS1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P005986:  view genomic region     (about GC identifiers)

Start:
5,986,736 bp from pter      End:
6,020,699 bp from pter
Size:
33,964 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRLS1_HUMAN, Q9UJA2 (See protein sequence)
Recommended Name: Cardiolipin synthase  
Size: 301 amino acids; 32593 Da
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Secondary accessions: D3DW09 E9PAT4 Q27RP0 Q69YQ5
Alternative splicing: 2 isoforms:  Q9UJA2-1   Q9UJA2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRLS1: NX_Q9UJA2

Explore proteomics data for CRLS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJA2

  • CRLS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRLS1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120930.1  NP_061968.1  

    ENSEMBL proteins: 
     ENSP00000368140   ENSP00000416770   ENSP00000368145  
    Reactome Protein details: Q9UJA2
    Human Recombinant Protein Products for CRLS1: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    CRLS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000462 CDP-OH_P_trans

    Graphical View of Domain Structure for InterPro Entry Q9UJA2

    ProtoNet protein and cluster: Q9UJA2

    1 Blocks protein domain: IPB000462 CDP-alcohol phosphatidyltransferase

    UniProtKB/Swiss-Prot: CRLS1_HUMAN, Q9UJA2
    Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family


    CRLS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRLS1_HUMAN, Q9UJA2
    Function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another
    to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
    Catalytic activity: 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol

         Enzyme Number (IUBMB): EC 2.7.8.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008444CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity ----
    GO:0016780phosphotransferase activity, for other substituted phosphate groups IEA--
         
    CRLS1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRLS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Acyl chain remodelling of PE
    Acyl chain remodelling of PG0.62
    4Synthesis of CL
    Synthesis of CL

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for CRLS1 (see all 6)
        Glycerophospholipid biosynthesis
    Synthesis of CL
    Metabolism
    Acyl chain remodelling of PG
    Phospholipid metabolism


    2         Kegg Pathways  (Kegg details for CRLS1):
        Glycerophospholipid metabolism
    Metabolic pathways


    CRLS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRLS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/84 Interacting proteins for CRLS1 (Q9UJA23 ENSP000003681404) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK6Q9Y3D83I2D: score=1 
    ENSG00000258947Q135093I2D: score=1 
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    RPL17P186213I2D: score=1 
    RPL17-C18orf32P186213I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0008654phospholipid biosynthetic process ----
    GO:0032049cardiolipin biosynthetic process TAS--
    GO:0036148phosphatidylglycerol acyl-chain remodeling TAS--
    GO:0044281small molecule metabolic process TAS--

    CRLS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRLS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRLS1

    10/94 HMDB Compounds for CRLS1 (see all 94)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:1(11Z))Cardiolipins(72:4) (see all 14)----
    CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:2(9Z,12Z))Cardiolipins(72:4) (see all 14)----
    CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(9Z))Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9) (see all 14)----
    CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:2(9Z,12Z))Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:0)Cardiolipins(72:5) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:1(9Z))Cardiolipins(72:5) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)/16:0)Cardiolipins(72:5) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)/16:1(9Z))Cardiolipins(72:5) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)/16:0)Cardiolipins(72:5) (see all 14)----
    CL(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)/16:1(9Z))Cardiolipins(72:5) (see all 14)----

    2 Novoseek inferred chemical compound relationships for CRLS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylglycerophosphate 93.8 3 8858564 (1), 19001357 (1)
    cardiolipin 87.5 21 16678169 (4), 16547353 (2), 20025994 (2), 16716149 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about CRLS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRLS1 gene (2 alternative transcripts): 
    NM_001127458.1  NM_019095.4  

    Unigene Cluster for CRLS1:

    Cardiolipin synthase 1
    Hs.743956  [show with all ESTs]
    Unigene Representative Sequence: NM_019095
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378863(uc002wmn.4 uc010gbq.3) ENST00000489345 ENST00000464921
    ENST00000478846 ENST00000452938 ENST00000378868(uc010gbs.1 uc010gbr.3)

    Congresses - knowledge worth sharing:  
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    Additional mRNA sequence: 

    AF241784.1 AK310368.1 AL832419.1 BC069010.1 DQ386730.1 

    22 DOTS entries:

    DT.315945  DT.97845839  DT.91765369  DT.100791962  DT.102831893  DT.91765373  DT.40208086  DT.120833357 
    DT.100791951  DT.100791963  DT.120833327  DT.40132694  DT.91765364  DT.97792108  DT.100791957  DT.91765382 
    DT.95197759  DT.120833319  DT.75143693  DT.75190263  DT.91672462  DT.95149694 

    24/311 AceView cDNA sequences (see all 311):

    CB159475 BI761976 AA045566 T93496 BF510585 N52709 AI761400 AI339837 
    BE465423 AI984318 T04917 BM761591 F02824 AW294325 AA548229 CK904798 
    AA393313 BU521886 NM_019095 BE219140 CB243251 AA759006 BM843106 AA978364 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CRLS1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -     -     -     -     -     -                             -     -     -                                                   
    SP2:                                                                                      -     -     -                                                   
    SP3:                    -     -     -     -     -     -     -                             -     -     -     -     -                                       
    SP4:                                      -     -     -     -                             -     -     -                                                   
    SP5:                                                        -                             -     -     -                                                   


    ECgene alternative splicing isoforms for CRLS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRLS1 expression in normal human tissues (normalized intensities)      CRLS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATATGCA
    CRLS1 Expression
    About this image


    CRLS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             primary visual cortex   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Lung (Respiratory System)

    See CRLS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRLS1

    SOURCE GeneReport for Unigene cluster: Hs.743956

    UniProtKB/Swiss-Prot: CRLS1_HUMAN, Q9UJA2
    Tissue specificity: Highly expressed in tissues such as heart, skeletal muscle and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRLS1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crls11 , 5 cardiolipin synthase 11, 5 86.67(n)1
    86.67(a)1
      2 (64.77 cM)5
    665861  NM_001024385.11  NP_001019556.11 
     1328466665 
    chicken
    (Gallus gallus)
    Aves CRLS11 cardiolipin synthase 1 76.79(n)
    77.68(a)
      428559  XM_426115.3  XP_426115.3 
    lizard
    (Anolis carolinensis)
    Reptilia CRLS16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(129353214-129360482)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.217072 Xenopus laevis transcribed sequence with weak similarity more 76.45(n)    BX843479.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.182352 Transcribed sequence with moderate similarity to protein more 71.28(n)    BQ091966.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CLS1 cardiolipin synthase 51.78(n)
    48.22(a)
      43104  NM_143161.1  NP_651418.1 
    worm
    (Caenorhabditis elegans)
    Secernentea crls-11 Protein CRLS-1 54.88(n)
    48.07(a)
      184910  NM_001027375.1  NP_001022546.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRD1(YDL142C)4 Cardiolipin synthase; produces cardiolipin, which is more   --   4(202570-201719) 851413  NP_010139.1 


    ENSEMBL Gene Tree for CRLS1 (if available)
    TreeFam Gene Tree for CRLS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/821 SNPs in CRLS1 are shown (see all 821)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121891051,2
    C--5968077(+) TTGTT-/AAAAAA 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1417221711,2
    --5984773(+) GGATGG/TTCTCC 1 -- us2k10--------
    rs786565261,2
    F--5984794(+) TGTTAG/AGGAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1139806141,2
    C,F--5984873(+) GCCAGC/GCACTT 1 -- us2k12Minor allele frequency- G:0.08CSA WA 120
    rs718827961,2
    C--5985082(+) TAAAC-/ATTGATA 1 -- us2k10--------
    rs1914276081,2
    --5985359(+) ATAAAA/CCCTAT 1 -- us2k10--------
    rs60769071,2
    C,H--5985365(+) CCTATC/GAGAGC 1 -- us2k110Minor allele frequency- G:0.00NA WA CSA EA 138
    rs64176281,2
    C,F,A,H--5985377(+) ACAAAT/GGGAAA 1 -- us2k1 tfbs3 trp311Minor allele frequency- G:0.28NA WA CSA EA 374
    rs60538241,2
    C,F,A,H--5985393(+) CAAAAA/G/TCAAGT 1 -- us2k112NA WA CSA EA 377
    rs1831940731,2
    --5985399(+) CAAGTC/TTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRLS1 (5986736 - 6020699 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRLS1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRLS1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRLS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608188    OMIM disorders: --

    7 diseases for CRLS1:    About MalaCards
    catastrophic antiphospholipid syndrome    antiphospholipid syndrome    endocarditis    pneumonia
    alcoholism    tuberculosis    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for CRLS1:
    Leigh disease

    CRLS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRLS1
    Human Genome Epidemiology (HuGE) Navigator: CRLS1 (1 document)

    Export disorders for CRLS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRLS1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CRLS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1). (PubMed id 16547353)1, 2, 3, 9 Lu B....Feingold K.R. (2006)
    2. Identification and characterization of human cardiolipin synthase. (PubMed id 16678169)1, 2, 9 Houtkooper R.H.... Vaz F.M. (2006)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria. (PubMed id 16716149)1, 9 Chen D....Shi Y. (2006)
    6. Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency. (PubMed id 22584571)1 Kiebish M.A....Gross R.W. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Cardiolipin synthase-1 mRNA expression does not corre late with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation. (PubMed id 20652826)1 Lu B....Hatch G.M. (2011)
    9. Infections and the antiphospholipid syndrome. (PubMed id 19089659)1 GarcA-a-Carrasco M....Cervera R. (2009)
    10. Clinical and laboratory features of the catastrophic antiphospholipid syndrome. (PubMed id 19052923)1 Stojanovich L....Milinic N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54675 HGNC: 16148 AceView: C20orf155 Ensembl:ENSG00000088766 euGenes: HUgn54675
    ECgene: CRLS1 Kegg: 54675 H-InvDB: CRLS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRLS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRLS1 gene:
    Search GeneIP for patents involving CRLS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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