CRLF3 Gene
protein-coding GIFtS: 48
GCID: GC17M029096
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cytokine receptor-like factor 3
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Aliases
for CRLF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytokine Receptor-Like Factor 31 2 | | CREME-92 3 | | CREME91 2 3 | | CRLM92 3 | | CYTOR41 2 3 | | FRWS2 | | Cytokine Receptor-Like Molecule 92 3 | | P48.21 | | Cytokine Receptor-Related Protein 42 3 | | P483 | | Type I Cytokine Receptor-Like Factor P482 3 | | |
Export aliases for CRLF3 gene to outside databasesPrevious GC identifers: GC17U990197 GC17M031015 GC17M028961 GC17M029255 GC17M026133 GC17M029109 GC17M025319 |
Summaries
for CRLF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CRLF3:
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesiclebiogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the qarm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements.Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified onchromosomes 2 and 5. (provided by RefSeq, Aug 2012)
UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8Function: May play a role in the negative regulation of cell cycle progression
Gene Wiki entry for CRLF3
|
Genomic Views
for CRLF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRLF3 gene promoter:
AML1a ATF-2 C/EBPalpha Arnt MEF-2A POU2F1 POU2F1a c-Myb aMEF-2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRLF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRLF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2CRLF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M029096: view genomic region
(about GC identifiers)
Start:
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29,096,406 bp from pter |
End:
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29,151,794 bp from pter |
Size:
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55,389 bases |
Orientation:
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minus strand |
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Proteins
for CRLF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8 (See
protein sequence)Recommended Name: Cytokine receptor-like factor 3 Size: 442 amino acids; 49766 Da
Subcellular location: Cytoplasm. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic(PubMed:19427400)
Secondary accessions: A6NJF3 B2R8C3 Q2MLY7 Q9UNI3 Q9Y6M8Alternative splicing: 2 isoforms: Q8IUI8-1 Q8IUI8-2 Explore the universe of human proteins at neXtProt for CRLF3: NX_Q8IUI8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUI8
CRLF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057070.3
ENSEMBL proteins: ENSP00000463689 ENSP00000318804 ENSP00000462643 ENSP00000444188
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
CRLF3 for ontologies About GeneDecksing
CRLF3 Antibody Products:
Assay Products for CRLF3: |
Protein
Domains /
Families
for CRLF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRLF3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUI8ProtoNet protein and cluster: Q8IUI8 UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8Similarity: Belongs to the cytokine receptor-like factor 3 familySimilarity: Contains 1 fibronectin type-III domain |
Function
for CRLF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8Function: May play a role in the negative regulation of cell cycle progression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRLF3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRLF3 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRLF3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
CRLF3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CRLF3:
Animal Models:
Mouse knock-out Crlf3tm1Lex for CRLF3
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Crlf3):
CRLF3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CRLF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRLF3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CRLF3 (Q8IUI83 ENSP000003188044) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
CRLF3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CRLF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRLF3
Search CenterWatch for drugs/clinical trials and news about CRLF3
|
Transcripts
for CRLF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRLF3 gene: NM_015986.3 Unigene Cluster for CRLF3: Cytokine receptor-like factor 3 Hs.649372 [show with all ESTs]Unigene Representative Sequence: NM_0159867 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000585268 ENST00000583527 ENST00000324238(uc002hfr.4 uc010wbr.2)
ENST00000578692 ENST00000577725 ENST00000583805 ENST00000544695
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRLF3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRLF3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CRLF3 (NM_015986) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRLF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRLF3 |
Additional cDNA sequence: AF046059.1 AK296238.1 AK313315.1 BC023567.2 DQ298450.1 NR_073118.1 11 DOTS entries: DT.120972694 DT.91759442 DT.86856643 DT.86852029 DT.100785475 DT.91845625 DT.100025611 DT.95245649 DT.100785476 DT.120937135 DT.97839707 24/87 AceView cDNA sequences (see all 87): N41853 AL602175 CF528502 AA322981 BM459869 AA993312 AW327680 BC023567 BQ027039 AW665312 BM771074 AA100364 AA360495 BU171570 CA420111 BM467501 BX282066 BU902521 BI551347 BM978231 N30610 BQ365820 BP367924 CF594335
GeneLoc Exon Structure
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Expression
for CRLF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRLF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTTTTCTA
About this image
See CRLF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRLF3
SOURCE GeneReport for Unigene cluster: Hs.649372
UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8Tissue specificity: Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleenand pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and inseveral other cancer types. Also detected in lesion actinic keratosis (AK)
SABiosciences Custom PCR Arrays for CRLF3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRLF3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRLF3 |
Orthologs
for CRLF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CRLF3 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for CRLF3 (if available)
TreeFam Gene Tree for CRLF3 (if available) |
Paralogs
for CRLF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRLF3 gene
CRLF3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CRLF3
PGOHUM00000240701 PGOHUM00000240822 PGOHUM00000235329
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Genomic Variants
for CRLF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRLF3 (29096406 - 29151794 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRLF3
1 Indel: 102437 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRLF3 |
|
Disorders
/ Diseases
for CRLF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRLF3 for disorders About GeneDecksing
OMIM gene information: 614853
OMIM disorders: --
10  diseases for CRLF3: About MalaCardsactinic keratosis neurofibromatosis skin squamous cell carcinoma squamous cell carcinoma
sotos syndrome keratosis ovarian cancer neuronitis
carcinoma leukemia
Human Genome Epidemiology (HuGE) Navigator: CRLF3 (3 documents)
Export disorders for CRLF3 gene to outside databases
|
Publications
for CRLF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRLF3 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CRLF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression. (PubMed id 19427400)1, 2 Yang F....Liu L. (2009)
- Identification of dysregulated genes in cutaneous squamous cell carcinoma. (PubMed id 16865251)1, 2 Dang C.... Nindl I. (2006)
- Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells. (PubMed id 16331330)1, 9 Yang F....Liu L. (2005)
- Uncovering genes required for neuronal morphology by m orphology-based gene trap screening with a revertible retrovirus vector. (PubMed id 22874834)1 Hashimoto Y....Harada A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1 Johnatty S.E.... . (2010)
- RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1 Visser R....Losekoot M. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for CRLF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CRLF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRLF3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRLF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CRLF3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CRLF3 gene:
Search GeneIP for patents involving CRLF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRLF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRLF3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRLF3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRLF3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRLF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRLF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRLF3 |
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 | | | CRLF3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRLF3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CRLF3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRLF3 |
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