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CRLF3 Gene

protein-coding   GIFtS: 50
GCID: GC17M029096

Cytokine Receptor-Like Factor 3

  See CRLF3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytokine Receptor-Like Factor 31 2     Type I Cytokine Receptor-Like Factor P482 3
CREME92 3 5     CREME-92 3
CRLM92 3 5     FRWS2
CYTOR42 3 5     p48.22
Cytokine Receptor-Like Molecule 92 3     P483
Cytokine Receptor-Related Protein 42 3     

External Ids:    HGNC: 171771   Entrez Gene: 513792   Ensembl: ENSG000001763907   OMIM: 6148535   UniProtKB: Q8IUI83   

Export aliases for CRLF3 gene to outside databases

Previous GC identifers: GC17U990197 GC17M031015 GC17M028961 GC17M029255 GC17M026133 GC17M029109 GC17M025319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRLF3 Gene:
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1
phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle
biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on
the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and
rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes
have been identified on chromosomes 2 and 5. (provided by RefSeq, Aug 2012)

GeneCards Summary for CRLF3 Gene:
CRLF3 (cytokine receptor-like factor 3) is a protein-coding gene. Diseases associated with CRLF3 include neurofibromatosis.

UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8
Function: May play a role in the negative regulation of cell cycle progression

Gene Wiki entry for CRLF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRLF3 gene promoter:
         AML1a   ATF-2   C/EBPalpha   Arnt   MEF-2A   POU2F1   POU2F1a   c-Myb   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRLF3 promoter sequence
   Search Chromatin IP Primers for CRLF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRLF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

CRLF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRLF3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M029096:  view genomic region     (about GC identifiers)

Start:
29,096,406 bp from pter      End:
29,151,794 bp from pter
Size:
55,389 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8 (See protein sequence)
Recommended Name: Cytokine receptor-like factor 3  
Size: 442 amino acids; 49766 Da
Secondary accessions: A6NJF3 B2R8C3 Q2MLY7 Q9UNI3 Q9Y6M8
Alternative splicing: 2 isoforms:  Q8IUI8-1   Q8IUI8-2   

Explore the universe of human proteins at neXtProt for CRLF3: NX_Q8IUI8

Explore proteomics data for CRLF3 at MOPED


See CRLF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_057070.3  
ENSEMBL proteins: 
 ENSP00000463689   ENSP00000318804   ENSP00000462643   ENSP00000444188  

CRLF3 Human Recombinant Protein Products:

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antibodies-online proteins for CRLF3 (2 products) 

 
antibodies-online peptides for CRLF3

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antibodies-online antibodies for CRLF3 (14 products) 

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antibodies-online kits for CRLF3 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR003961 Fibronectin_type3
 IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry Q8IUI8

ProtoNet protein and cluster: Q8IUI8

UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8
Similarity: Belongs to the cytokine receptor-like factor 3 family
Similarity: Contains 1 fibronectin type-III domain


Find genes that share domains with CRLF3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CRLF3_HUMAN, Q8IUI8
Function: May play a role in the negative regulation of cell cycle progression

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with CRLF3           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for CRLF3:
 Increased Salmonella enterica   Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crlf3):
 growth/size/body  hematopoietic system  homeostasis/metabolism 

Find genes that share phenotypes with CRLF3           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Crlf3tm1Lex for CRLF3

   genOway: Develop your customized and physiologically relevant rodent model for CRLF3

miRNA
Products:
    
miRTarBase miRNAs that target CRLF3:
hsa-mir-671-5p (MIRT039257), hsa-mir-375 (MIRT019999), hsa-mir-192-5p (MIRT026882), hsa-mir-215-5p (MIRT024952)

Block miRNA regulation of human, mouse, rat CRLF3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CRLF3 (see all 26):
hsa-miR-607 hsa-miR-520d-5p hsa-miR-1288 hsa-miR-10b hsa-miR-200a hsa-miR-219-5p hsa-miR-888* hsa-miR-508-3p
SwitchGear 3'UTR luciferase reporter plasmidCRLF3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat CRLF3

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRLF3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRLF3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CRLF3_HUMAN, Q8IUI8: Cytoplasm. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic
(PubMed:19427400)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
cytoskeleton1
extracellular1
peroxisome1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA19427400

Find genes that share ontologies with CRLF3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRLF3
Interactions:

    Search GeneGlobe Interaction Network for CRLF3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for CRLF3 (Q8IUI83 ENSP000003188044) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
WASF2Q9Y6W53I2D: score=1 
ELAVL1ENSP000003852694STRING: ENSP00000385269
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000082G1/S transition of mitotic cell cycle IMP19427400
GO:0030308negative regulation of cell growth IDA19427400
GO:0045893positive regulation of transcription, DNA-templated IDA19427400
GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA19427400
GO:0046427positive regulation of JAK-STAT cascade IDA19427400

Find genes that share ontologies with CRLF3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CRLF3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CRLF3 gene: 
NM_015986.3  

Unigene Cluster for CRLF3:

Cytokine receptor-like factor 3
Hs.649372  [show with all ESTs]
Unigene Representative Sequence: NM_015986
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000585268 ENST00000583527 ENST00000324238(uc002hfr.4 uc010wbr.2)
ENST00000578692 ENST00000577725 ENST00000583805 ENST00000544695
miRNA
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Block miRNA regulation of human, mouse, rat CRLF3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CRLF3 (see all 26):
hsa-miR-607 hsa-miR-520d-5p hsa-miR-1288 hsa-miR-10b hsa-miR-200a hsa-miR-219-5p hsa-miR-888* hsa-miR-508-3p
SwitchGear 3'UTR luciferase reporter plasmidCRLF3 3' UTR sequence
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Predesigned siRNA for gene silencing in human, mouse, rat CRLF3
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Primer
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OriGene qPCR primer pairs and template standards for CRLF3
OriGene qSTAR qPCR primer pairs in human, mouse for CRLF3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRLF3
  QuantiTect SYBR Green Assays in human, mouse, rat CRLF3
  QuantiFast Probe-based Assays in human, mouse, rat CRLF3

Additional mRNA sequence: 

AF046059.1 AK296238.1 AK313315.1 BC023567.2 DQ298450.1 NR_073118.1 

11 DOTS entries:

DT.120972694  DT.91759442  DT.86856643  DT.86852029  DT.100785475  DT.91845625  DT.95245649  DT.100025611 
DT.100785476  DT.120937135  DT.97839707 

Selected AceView cDNA sequences (see all 87):

AA322981 CF528502 AL602175 BM771074 BC023567 BU171570 BM459869 AW327680 
AW665312 BQ027039 N41853 AA993312 CA420111 AA360495 BM467501 AA100364 
BM978231 BX282066 BQ921176 BU154401 N30610 AI357196 CF594335 CA427410 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CRLF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCTTTTCTA
CRLF3 Expression
About this image


CRLF3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Thymus (Hematopoietic System)
         Thymus
 
 Liver (Hepatobiliary System)
CRLF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CRLF3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.649372

UniProtKB/Swiss-Prot: CRLF3_HUMAN, Q8IUI8
Tissue specificity: Expressed in several embryonic and adult tissues, including adult and fetal brain, liver,
spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma
(SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK)

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRLF3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CRLF3 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Crlf31 , 5 cytokine receptor-like factor 31, 5 87.56(n)1
92.99(a)1
  11 (47.43 cM)5
543941  NM_018776.21  NP_061246.11 
 800464935 
chicken
(Gallus gallus)
Aves CRLF31 cytokine receptor-like factor 3 78.4(n)
82.86(a)
  417407  NM_001079719.2  NP_001073187.2 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
80(a)
79(a)
many → 1
many → 1
AAWZ02039243(819-6711)
GL343198.1(1486355-1512523)
African clawed frog
(Xenopus laevis)
Amphibia crlf3-prov2 cytokine receptor-like factor 3 76.13(n)    BC045226.1 
zebrafish
(Danio rerio)
Actinopterygii crlf31 cytokine receptor-like factor 3 63.93(n)
67.21(a)
  550515  NM_001017817.2  NP_001017817.2 


ENSEMBL Gene Tree for CRLF3 (if available)
TreeFam Gene Tree for CRLF3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CRLF3 gene

Find genes that share paralogs with CRLF3           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for CRLF3
PGOHUM00000240701 PGOHUM00000240822 PGOHUM00000235329


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CRLF3 (see all 1058)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs605461311,2
C--29109909(+) TACTA-/TACTGGT 2 -- ut31 nc-transcript-variant0--------
rs603021551,2
C--29111835(+) GCATG-/GCATG 
        
ATCTG
2 -- int10--------
rs564124161,2
C--29112660(+) CCAGT-/CACAGTG 2 -- int10--------
rs557517161,2
C--29113172(+) AGCAA-/CCATGA 2 -- int10--------
rs1134229761,2
C,F--29113405(+) GTGCCT/CGCCAC 2 -- int11Minor allele frequency- C:0.00CSA 1
rs2006893361,2
C--29113717(+) TCTAT-/CTAT  
        
TTTTT
2 -- int10--------
rs563735361,2
C--29114362(+) AAAAA-/ATCCCA 2 -- int10--------
rs3730237191,2
C--29114553(+) GGACA-/AA    
   AAAAA
AAAAA
2 -- int10--------
rs713722371,2
C--29117820(+) TAGTAG/AAGACG 2 -- int11Minor allele frequency- A:0.50NA 2
rs112777851,2
C--29119803(+) AATAA-/ATCAC 
        
ACAAG
2 -- int10--------

HapMap Linkage Disequilibrium report for CRLF3 (29096406 - 29151794 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CRLF3 (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2661289CNV Deletion23128226
esv2715813CNV Deletion23290073
esv2596745CNV Insertion19546169
nsv513468CNV Insertion21212237
nsv833412CNV Loss17160897
nsv908053CNV Loss21882294
dgv3140n71CNV Loss21882294
nsv457720CNV Loss19166990
nsv908050CNV Loss21882294
nsv833411CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CRLF3
DNA2.0 Custom Variant and Variant Library Synthesis for CRLF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614853    OMIM disorders: --

1 disease for CRLF3:    
About MalaCards
neurofibromatosis


Find genes that share disorders with CRLF3           About GenesLikeMe

Genetic Association Database (GAD): CRLF3
Human Genome Epidemiology (HuGE) Navigator: CRLF3 (3 documents)

Export disorders for CRLF3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CRLF3 gene, integrated from 10 sources (see all 26):
(articles sorted by number of sources associating them with CRLF3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
  3. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1, 4 Visser R.... Losekoot M. (Am. J. Med. Genet. A 2009)
  4. Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression. (PubMed id 19427400)1, 2 Yang F.... Liu L. (Int. J. Biochem. Cell Biol. 2009)
  5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
  6. Identification of dysregulated genes in cutaneous squamous cell carcinoma. (PubMed id 16865251)1, 2 Dang C.... Nindl I. (Oncol. Rep. 2006)
  7. Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells. (PubMed id 16331330)1, 9 Yang F....Liu L. (Acta Biochim. Biophys. Sin. (Shanghai) 2005)
  8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
  9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  10. Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector. (PubMed id 22874834)1 Hashimoto Y....Harada A. (FASEB J. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51379 HGNC: 17177 AceView: CRLF3 Ensembl:ENSG00000176390 euGenes: HUgn51379
ECgene: CRLF3 H-InvDB: CRLF3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CRLF3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CRLF3 gene:
Search GeneIP for patents involving CRLF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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