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Aliases for CRLF3 Gene

Aliases for CRLF3 Gene

  • Cytokine Receptor Like Factor 3 2 3
  • Type I Cytokine Receptor-Like Factor P48 3 4
  • Cytokine Receptor-Related Protein 4 3 4
  • Cytokine Receptor-Like Molecule 9 3 4
  • Cytokine Receptor-Like Factor 3 2 5
  • CREME-9 3 4
  • CREME9 3 4
  • CYTOR4 3 4
  • CRLM9 3 4
  • P48.2 3
  • FRWS 3
  • P48 4

External Ids for CRLF3 Gene

Previous GeneCards Identifiers for CRLF3 Gene

  • GC17U990197
  • GC17M031015
  • GC17M028961
  • GC17M029255
  • GC17M026133
  • GC17M029109
  • GC17M025319
  • GC17M029096

Summaries for CRLF3 Gene

Entrez Gene Summary for CRLF3 Gene

  • This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

GeneCards Summary for CRLF3 Gene

CRLF3 (Cytokine Receptor Like Factor 3) is a Protein Coding gene. Diseases associated with CRLF3 include neurofibromatosis.

UniProtKB/Swiss-Prot for CRLF3 Gene

  • May play a role in the negative regulation of cell cycle progression.

Gene Wiki entry for CRLF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRLF3 Gene

Genomics for CRLF3 Gene

Regulatory Elements for CRLF3 Gene

Promoters for CRLF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRLF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRLF3 Gene

Chromosome:
17
Start:
30,769,388 bp from pter
End:
30,824,776 bp from pter
Size:
55,389 bases
Orientation:
Minus strand

Genomic View for CRLF3 Gene

Genes around CRLF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRLF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRLF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRLF3 Gene

Proteins for CRLF3 Gene

  • Protein details for CRLF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUI8-CRLF3_HUMAN
    Recommended name:
    Cytokine receptor-like factor 3
    Protein Accession:
    Q8IUI8
    Secondary Accessions:
    • A6NJF3
    • B2R8C3
    • Q2MLY7
    • Q9UNI3
    • Q9Y6M8

    Protein attributes for CRLF3 Gene

    Size:
    442 amino acids
    Molecular mass:
    49766 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRLF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRLF3 Gene

Proteomics data for CRLF3 Gene at MOPED

Post-translational modifications for CRLF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRLF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRLF3 Gene

Domains & Families for CRLF3 Gene

Protein Domains for CRLF3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IUI8

UniProtKB/Swiss-Prot:

CRLF3_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Belongs to the cytokine receptor-like factor 3 family.
Domain:
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the cytokine receptor-like factor 3 family.
genes like me logo Genes that share domains with CRLF3: view

No data available for Gene Families for CRLF3 Gene

Function for CRLF3 Gene

Molecular function for CRLF3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the negative regulation of cell cycle progression.
genes like me logo Genes that share phenotypes with CRLF3: view

Animal Models for CRLF3 Gene

MGI Knock Outs for CRLF3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRLF3

miRNA for CRLF3 Gene

miRTarBase miRNAs that target CRLF3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRLF3 Gene

Localization for CRLF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRLF3 Gene

Cytoplasm. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. {ECO:0000269 PubMed:19427400}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRLF3 Gene COMPARTMENTS Subcellular localization image for CRLF3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CRLF3: view

Pathways & Interactions for CRLF3 Gene

SuperPathways for CRLF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRLF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 19427400
GO:0045893 positive regulation of transcription, DNA-templated IDA 19427400
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 19427400
genes like me logo Genes that share ontologies with CRLF3: view

No data available for Pathways by source and SIGNOR curated interactions for CRLF3 Gene

Drugs & Compounds for CRLF3 Gene

No Compound Related Data Available

Transcripts for CRLF3 Gene

Unigene Clusters for CRLF3 Gene

Cytokine receptor-like factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRLF3 Gene

No ASD Table

Relevant External Links for CRLF3 Gene

GeneLoc Exon Structure for
CRLF3
ECgene alternative splicing isoforms for
CRLF3

Expression for CRLF3 Gene

mRNA expression in normal human tissues for CRLF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRLF3 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for CRLF3 Gene

This gene is overexpressed in Lymph node (16.3), Peripheral blood mononuclear cells (15.4), and Tlymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CRLF3 Gene



SOURCE GeneReport for Unigene cluster for CRLF3 Gene Hs.649372

mRNA Expression by UniProt/SwissProt for CRLF3 Gene

Q8IUI8-CRLF3_HUMAN
Tissue specificity: Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).
genes like me logo Genes that share expression patterns with CRLF3: view

Protein tissue co-expression partners for CRLF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CRLF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRLF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRLF3 36
  • 100 (a)
OneToOne
CRLF3 35
  • 99.62 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CRLF3 36
  • 95 (a)
OneToOne
CRLF3 35
  • 91.25 (n)
  • 95.66 (a)
dog
(Canis familiaris)
Mammalia CRLF3 35
  • 92.43 (n)
  • 96.25 (a)
CRLF3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crlf3 16
Crlf3 35
  • 87.56 (n)
  • 92.99 (a)
Crlf3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRLF3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRLF3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crlf3 35
  • 86.95 (n)
  • 91.86 (a)
chicken
(Gallus gallus)
Aves CRLF3 35
  • 78.4 (n)
  • 82.86 (a)
CRLF3 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia crlf3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia crlf3 35
  • 67.21 (n)
  • 70.42 (a)
Str.2975 35
zebrafish
(Danio rerio)
Actinopterygii crlf3 36
  • 65 (a)
OneToOne
crlf3 35
  • 63.93 (n)
  • 67.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for CRLF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRLF3 Gene

ENSEMBL:
Gene Tree for CRLF3 (if available)
TreeFam:
Gene Tree for CRLF3 (if available)

Paralogs for CRLF3 Gene

Pseudogenes.org Pseudogenes for CRLF3 Gene

genes like me logo Genes that share paralogs with CRLF3: view

No data available for Paralogs for CRLF3 Gene

Variants for CRLF3 Gene

Sequence variations from dbSNP and Humsavar for CRLF3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11867457 - 30,784,350(+) TTCCT(A/G)GAGTC nc-transcript-variant, reference, missense
rs3764418 - 30,793,672(-) CCTAG(A/G)TGGAT nc-transcript-variant, reference, missense
rs963680 -- 30,784,701(+) TATTT(C/T)TTATG intron-variant
rs3967191 -- 30,790,018(-) CAACA(A/G)AGAGA intron-variant
rs7213542 -- 30,824,808(+) CCTCG(A/C)GCGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRLF3 Gene

Variant ID Type Subtype PubMed ID
esv2715813 CNV Deletion 23290073
nsv457720 CNV Loss 19166990
dgv3139n71 CNV Gain 21882294
nsv908050 CNV Loss 21882294
dgv3140n71 CNV Loss 21882294
nsv833411 CNV Loss 17160897
nsv908053 CNV Loss 21882294
esv2661289 CNV Deletion 23128226
nsv513468 CNV Insertion 21212237
esv2596745 CNV Insertion 19546169
nsv833412 CNV Loss 17160897

Variation tolerance for CRLF3 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRLF3 Gene

HapMap Linkage Disequilibrium report
CRLF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRLF3 Gene

Disorders for CRLF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRLF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neurofibromatosis
  • acoustic neurofibromatosis
- elite association - COSMIC cancer census association via MalaCards
Search CRLF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRLF3

Genetic Association Database (GAD)
CRLF3
Human Genome Epidemiology (HuGE) Navigator
CRLF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRLF3
genes like me logo Genes that share disorders with CRLF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRLF3 Gene

Publications for CRLF3 Gene

  1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48 67
  2. Establishment and utilization of a tetracycline-controlled inducible RNA interfering system to repress gene expression in chronic myelogenous leukemia cells. (PMID: 16331330) Yang F. … Liu L. (Acta Biochim. Biophys. Sin. (Shanghai) 2005) 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CRLF3 Gene

Sources for CRLF3 Gene

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