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CRLF2 Gene

protein-coding   GIFtS: 51
GCID: GC0XM001274

Cytokine Receptor-Like Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytokine Receptor-Like Factor 21 2     CRLF2Y2
Cytokine Receptor-Like 22 3     Cytokine Receptor CRL2 Precusor2
Thymic Stromal Lymphopoietin Protein Receptor2 3     P2RY8/CRLF2 Fusion2
CRL22 3     Thymic Stromal Lymphopoietin Receptor2
IL-XR2 3     Thymic Stromal-Derived Lymphopoietin Receptor2
TSLPR2 3     ILXR3
TSLP Receptor2 3     

External Ids:    HGNC: 142811   Entrez Gene: 641092   Ensembl: ENSG000002057557   OMIM: 300357,4000235   UniProtKB: Q9HC733   

Export aliases for CRLF2 gene to outside databases

Previous GC identifers: GC00U990849 GC0YU900015 GC0XM9W0034 GC0XP9W0020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRLF2 Gene:
The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the
interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which
control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for CRLF2 Gene:
CRLF2 (cytokine receptor-like factor 2) is a protein-coding gene. Diseases associated with CRLF2 include cblc, and eczema herpeticum.

UniProtKB/Swiss-Prot: CRLF2_HUMAN, Q9HC73
Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is
capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By
similarity). Implicated in the development of the hematopoietic system

Gene Wiki entry for CRLF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_000024.10  NC_018934.2  NT_167201.2  NT_187358.1  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CRLF2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CRLF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRLF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3 and Yp11.3

CRLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRLF2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM001274:  view genomic region     (about GC identifiers)

Start:
1,314,869 bp from pter      End:
1,331,616 bp from pter
Size:
16,748 bases      Orientation:
minus strand

1 alternative location:
ChrY- 1,264,869-1,281,529     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRLF2_HUMAN, Q9HC73 (See protein sequence)
Recommended Name: Cytokine receptor-like factor 2 precursor  
Size: 371 amino acids; 42013 Da
Subunit: Heterodimer of CRLF2 and IL7R
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes
Secondary accessions: Q9H5R3
Alternative splicing: 2 isoforms:  Q9HC73-1   Q9HC73-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRLF2: NX_Q9HC73

Explore proteomics data for CRLF2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47, Asn55, Asn101, Asn169

  • See CRLF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012288.2  NP_071431.2  

    ENSEMBL proteins: 
     ENSP00000383641   ENSP00000370979   ENSP00000370978  

    CRLF2 Human Recombinant Protein Products:

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    CRLF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRLF2
    R&D Systems Antibodies for CRLF2 (TSLP R)
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    Cloud-Clone Corp. CLIAs for CRLF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PAR1: Pseudoautosomal regions / PAR1

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cytokine receptor-like factor 2
    IL-2 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q9HC73

    ProtoNet protein and cluster: Q9HC73

    UniProtKB/Swiss-Prot: CRLF2_HUMAN, Q9HC73
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is important for association with JAKs
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
    Similarity: Contains 1 fibronectin type-III domain


    CRLF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRLF2_HUMAN, Q9HC73
    Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is
    capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By
    similarity). Implicated in the development of the hematopoietic system
    Induction: Up-regulated in activated peripheral monocytes and THP-1 cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CRLF2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRLF2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRLF2_HUMAN, Q9HC73: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable)
    CRLF2_HUMAN, Q9HC73: Isoform 2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    CRLF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRLF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    2TSLP Signaling Pathway
    TSLP Signaling Pathway
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CRLF2
        TSLP Signaling Pathway


    2 Kegg Pathways  (Kegg details for CRLF2):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    CRLF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRLF2: 
              Interferons & Receptors in human mouse rat
              Insulin Resistance in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CRLF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CRLF2 (Q9HC733 ENSP000003709794) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL7RP168713, ENSP000003061574I2D: score=1 STRING: ENSP00000306157
    TSLPQ969D93, ENSP000003398044I2D: score=1 STRING: ENSP00000339804
    JAK2O606743, ENSP000003710674I2D: score=1 STRING: ENSP00000371067
    CBLENSP000002640334STRING: ENSP00000264033
    CBLBENSP000002641224STRING: ENSP00000264122
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRLF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRLF2 gene (2 alternative transcripts): 
    NM_001012288.2  NM_022148.3  

    Unigene Cluster for CRLF2:

    Cytokine receptor-like factor 2
    Hs.287729
    Unigene Representative Sequence: AK225583
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400841 ENST00000467626 ENST00000381567(uc004cpk.2 uc004cpl.2 uc022brs.1 uc022brt.1)
    ENST00000381566
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CRLF2

    Additional mRNA sequence: 

    AB052639.1 AF142570.1 AF338733.1 AK223303.1 AK225583.1 AY775789.1 GQ280263.1 

    6 DOTS entries:

    DT.121323112  DT.91850991  DT.120652185  DT.120652187  DT.121323114  DT.97829485 

    3 AceView cDNA sequences:

    AB052639 AK026800 AF338733 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRLF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCAGAGA
    CRLF2 Expression
    About this image

    CRLF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRLF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287729

    UniProtKB/Swiss-Prot: CRLF2_HUMAN, Q9HC73
    Tissue specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in
    dendrites and monocytes. Weakly expressed in T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRLF2: 
              Interferons & Receptors in human mouse rat
              Insulin Resistance in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRLF2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crlf21 cytokine receptor-like factor 2 50.1(n)
    37.28(a)
      57914  NM_016715.4  NP_057924.3 
    chicken
    (Gallus gallus)
    Aves LOC4186681 cytokine receptor-like factor 2-like 49.11(n)
    37.54(a)
      418668  XM_416864.4  XP_416864.3 


    ENSEMBL Gene Tree for CRLF2 (if available)
    TreeFam Gene Tree for CRLF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRLF2 gene
    2 SIMAP similar genes for CRLF2 using alignment to 3 protein entries:     CRLF2_HUMAN (see all proteins):
    CRLF2 fusion    TSLPR

    CRLF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CRLF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739632CNV Deletion23290073
    esv2739634CNV Deletion23290073
    esv2739633CNV Deletion23290073
    esv2739630CNV Deletion23290073
    esv2739631CNV Deletion23290073
    esv29996CNV Loss17803354
    esv21933CNV Gain+Loss19812545

    1 Site Specific Mutation Identification with PCR Assay for CRLF2:
    Cosmic IdAA Change
    41268p.F232C
    4 Site Specific Cancer Mutation PCR Panels containing CRLF2:
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Lymphoid Neoplasms
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CRLF2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRLF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300357,400023    OMIM disorders: --

    14 diseases for CRLF2:    About MalaCards
    cblc    eczema herpeticum    atopic dermatitis    precursor b-cell acute lymphoblastic leukemia
    atopy    down syndrome    lymphoblastic leukemia    dermatitis
    acute leukemia    asthma    psoriasis    insulin resistance
    t-cell leukemia    leukemia

    3 diseases from the University of Copenhagen DISEASES database for CRLF2:
    Leukemia     Down syndrome     Atopic dermatitis

    CRLF2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CRLF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 42 1 20483734 (1)

    Genetic Association Database (GAD): CRLF2
    Human Genome Epidemiology (HuGE) Navigator: CRLF2 (2 documents)

    Export disorders for CRLF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRLF2 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with CRLF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. (PubMed id 11237741)1, 2, 3, 9 Zhang W.... Cao X. (Biochem. Biophys. Res. Commun. 2001)
    2. Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. (PubMed id 11474172)1, 2, 3, 9 Tonozuka Y.... Kitamura T. (Cytogenet. Cell Genet. 2001)
    3. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. (PubMed id 20466416)1, 4 Gao P.S....Barnes K.C. (J. Allergy Clin. Immunol. 2010)
    4. Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma. (PubMed id 20663412)1, 4 Yu J.I....Chae S.C. (BMB Rep 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. (PubMed id 11418668)1, 2 Reche P.A.... Bazan J.F. (J. Immunol. 2001)
    7. Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. (PubMed id 11891057)1, 9 Blagoev B....Pandey A. (Gene 2002)
    8. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. (PubMed id 19641190)1, 9 Russell L.J....Harrison C.J. (Blood 2009)
    9. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. (PubMed id 19965641)1, 9 Hertzberg L....Izraeli S. (Blood 2010)
    10. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. (PubMed id 20483734)1, 9 Shan L....Gounni A.S. (J. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64109 HGNC: 14281 AceView: CRLF2 Ensembl:ENSG00000205755 euGenes: HUgn64109
    ECgene: CRLF2 Kegg: 64109 H-InvDB: CRLF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRLF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRLF2 gene:
    Search GeneIP for patents involving CRLF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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