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Aliases for CRLF2 Gene

Aliases for CRLF2 Gene

  • Cytokine Receptor-Like Factor 2 2 3 5
  • Thymic Stromal Lymphopoietin Protein Receptor 3 4
  • TSLP Receptor 3 4
  • IL-XR 3 4
  • TSLPR 3 4
  • CRL2 3 4
  • Thymic Stromal-Derived Lymphopoietin Receptor 3
  • Cytokine Receptor CRL2 Precusor 3
  • Cytokine Receptor-Like 2 4
  • CRLF2Y 3
  • ILXR 4

External Ids for CRLF2 Gene

Previous GeneCards Identifiers for CRLF2 Gene

  • GC00U990849
  • GC0YU900015
  • GC0XM9W0034
  • GC0XP9W0020

Summaries for CRLF2 Gene

Entrez Gene Summary for CRLF2 Gene

  • This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CRLF2 Gene

CRLF2 (Cytokine Receptor-Like Factor 2) is a Protein Coding gene. Diseases associated with CRLF2 include Lymphoblastic Leukemia and Down Syndrome. Among its related pathways are Jak-STAT signaling pathway and PEDF Induced Signaling.

UniProtKB/Swiss-Prot for CRLF2 Gene

  • Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

Gene Wiki entry for CRLF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRLF2 Gene

Genomics for CRLF2 Gene

Regulatory Elements for CRLF2 Gene

Enhancers for CRLF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRLF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRLF2 Gene

Chromosome:
X
Start:
1,187,549 bp from pter
End:
1,212,815 bp from pter
Size:
25,267 bases
Orientation:
Minus strand

Genomic View for CRLF2 Gene

Genes around CRLF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRLF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRLF2 Gene

Proteins for CRLF2 Gene

  • Protein details for CRLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC73-CRLF2_HUMAN
    Recommended name:
    Cytokine receptor-like factor 2
    Protein Accession:
    Q9HC73
    Secondary Accessions:
    • J3QKD1
    • Q5G7M1
    • Q9H5R3

    Protein attributes for CRLF2 Gene

    Size:
    371 amino acids
    Molecular mass:
    42013 Da
    Quaternary structure:
    • Heterodimer of CRLF2 and IL7R.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Alternative splice isoforms for CRLF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRLF2 Gene

Proteomics data for CRLF2 Gene at MOPED

Post-translational modifications for CRLF2 Gene

  • Glycosylation at Asn 47, Asn 55, Asn 101, and Asn 169
  • Modification sites at PhosphoSitePlus

Other Protein References for CRLF2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CRLF2

No data available for DME Specific Peptides for CRLF2 Gene

Domains & Families for CRLF2 Gene

Gene Families for CRLF2 Gene

Protein Domains for CRLF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRLF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC73

UniProtKB/Swiss-Prot:

CRLF2_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is important for association with JAKs.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with CRLF2: view

Function for CRLF2 Gene

Molecular function for CRLF2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
UniProtKB/Swiss-Prot Induction:
Up-regulated in activated peripheral monocytes and THP-1 cells.
genes like me logo Genes that share phenotypes with CRLF2: view

Animal Models for CRLF2 Gene

MGI Knock Outs for CRLF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRLF2

miRNA for CRLF2 Gene

miRTarBase miRNAs that target CRLF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRLF2 Gene

Localization for CRLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRLF2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRLF2 Gene COMPARTMENTS Subcellular localization image for CRLF2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRLF2: view

Pathways & Interactions for CRLF2 Gene

genes like me logo Genes that share pathways with CRLF2: view

Pathways by source for CRLF2 Gene

1 BioSystems pathway for CRLF2 Gene

SIGNOR curated interactions for CRLF2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CRLF2 Gene

None

Drugs & Compounds for CRLF2 Gene

(1) Drugs for CRLF2 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N/A Pharma inhibitor 0
genes like me logo Genes that share compounds with CRLF2: view

Transcripts for CRLF2 Gene

mRNA/cDNA for CRLF2 Gene

(6) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CRLF2 Gene

No ASD Table

Relevant External Links for CRLF2 Gene

GeneLoc Exon Structure for
CRLF2
ECgene alternative splicing isoforms for
CRLF2

Expression for CRLF2 Gene

mRNA expression in normal human tissues for CRLF2 Gene

Protein differential expression in normal tissues from HIPED for CRLF2 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRLF2 Gene



SOURCE GeneReport for Unigene cluster for CRLF2 Gene Hs.287729

mRNA Expression by UniProt/SwissProt for CRLF2 Gene

Q9HC73-CRLF2_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
genes like me logo Genes that share expression patterns with CRLF2: view

Protein tissue co-expression partners for CRLF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRLF2 Gene

Orthologs for CRLF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRLF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC529792 35
  • 67.86 (n)
  • 58.68 (a)
CRLF2 36
  • 37 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRLF2 35
  • 71.32 (n)
  • 61.37 (a)
CRLF2 36
  • 39 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crlf2 35
  • 50.1 (n)
  • 37.28 (a)
Crlf2 16
Crlf2 36
  • 22 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRLF2 35
  • 98.76 (n)
  • 99.25 (a)
rat
(Rattus norvegicus)
Mammalia Crlf2 35
  • 49.23 (n)
  • 38.39 (a)
oppossum
(Monodelphis domestica)
Mammalia CRLF2 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRLF2 36
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC418668 35
  • 49.11 (n)
  • 37.54 (a)
CRLF2 36
  • 25 (a)
OneToOne
Species with no ortholog for CRLF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRLF2 Gene

ENSEMBL:
Gene Tree for CRLF2 (if available)
TreeFam:
Gene Tree for CRLF2 (if available)

Paralogs for CRLF2 Gene

(2) SIMAP similar genes for CRLF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRLF2: view

No data available for Paralogs for CRLF2 Gene

Variants for CRLF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRLF2 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv21933 CNV Gain+Loss 19812545
esv2739630 CNV Deletion 23290073
esv2739631 CNV Deletion 23290073
esv2739632 CNV Deletion 23290073
esv2739633 CNV Deletion 23290073
esv2739634 CNV Deletion 23290073

Variation tolerance for CRLF2 Gene

Gene Damage Index Score: 1.93; 35.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for CRLF2 Gene

Disorders for CRLF2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRLF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • acute lymphocytic leukemia
down syndrome
  • complete trisomy 21 syndrome
precursor b-cell acute lymphoblastic leukemia
  • b-all
- elite association - COSMIC cancer census association via MalaCards
Search CRLF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRLF2

Genetic Association Database (GAD)
CRLF2
Human Genome Epidemiology (HuGE) Navigator
CRLF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRLF2
genes like me logo Genes that share disorders with CRLF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRLF2 Gene

Publications for CRLF2 Gene

  1. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. (PMID: 11237741) Zhang W. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. (PMID: 11474172) Tonozuka Y. … Kitamura T. (Cytogenet. Cell Genet. 2001) 2 3 23
  3. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. (PMID: 19965641) Hertzberg L. … Izraeli S. (Blood 2010) 3 23
  4. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. (PMID: 20128689) Wohlmann A. … Friedrich K. (Biol. Chem. 2010) 3 23
  5. Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. (PMID: 20236697) Semlali A. … Chakir J. (J. Allergy Clin. Immunol. 2010) 3 23

Products for CRLF2 Gene

Sources for CRLF2 Gene

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