Aliases for CRLF1 Gene
External Ids for CRLF1 Gene
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
GeneCards Summary for CRLF1 Gene
CRLF1 (Cytokine Receptor-Like Factor 1) is a Protein Coding gene. Diseases associated with CRLF1 include labyrinthitis and cold-induced sweating syndrome including crisponi syndrome. Among its related pathways are Translation Insulin regulation of translation. GO annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is GHR.
UniProtKB/Swiss-Prot for CRLF1 Gene
Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development