Aliases for CRLF1 Gene
External Ids for CRLF1 Gene
Previous GeneCards Identifiers for CRLF1 Gene
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
GeneCards Summary for CRLF1 Gene
CRLF1 (Cytokine Receptor Like Factor 1) is a Protein Coding gene. Diseases associated with CRLF1 include Cold-Induced Sweating Syndrome 1 and Cold-Induced Sweating Syndrome Including Crisponi Syndrome. Among its related pathways are Immune System and Interleukin-6 family signaling. GO annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is PRLR.
UniProtKB/Swiss-Prot for CRLF1 Gene
Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.