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CRKL Gene

protein-coding GIFtS: 66

GC22P019596

v-crk sarcoma virus CT10 oncogene homolog (avian)-like
(Previous name: v-crk avian sarcoma virus CT10 oncogene homolog-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Descriptions
v-crk avian sarcoma virus CT10 oncogene homolog-like ^¹, ²
v-crk sarcoma virus CT10 oncogene homolog (avian)-like ^²

External Ids
HGNC: 2363¹
Entrez Gene: 1399²
UniProtKB: P46109³
Ensembl: ENSG00000099942⁷

Search outside databases for aliases for CRKL gene

Previous GC identifer: GC22P017970

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CRKL:

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been

shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a

RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in

fibroblast transformation by BCR-ABL, and may be oncogenic.

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109

Function: May mediate the transduction of intracellular signals

Gene Wiki entry for CRKL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRKL gene

Entrez Gene cytogenetic band: 22q11|22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

CRKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P019596: (about GC identifiers)

Start:	19,601,714 bp from pter
End:	19,637,890 bp from pter
Size:	36,177 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109 (See protein sequence)

Recommended Name: Crk-like protein

Size: 303 amino acids; 33777 Da

Subunit: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated

CBLB and IRS4

PDB structures from and Proteopedia :

2BZX (3D)

2BZY (3D)

2DBK (3D)

2EO3 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005198.1

ENSEMBL proteins:

ENSP00000346300

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CrkL)
	Human Recombinant Proteins from Abnova (CRKL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IDA	18029348

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Antibodies for CRKL:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CRKL
	Sigma-Aldrich Antibody Arrays and Antibodies for CRKL
	R&D Systems Antibodies for CRKL
	Cell Signaling Technology (CST) Antibodies for CRKL
	Antibodies from Abcam (CrkL), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRKL)
	Novus Biologicals Antibodies for CRKL

Assays for CRKL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P46109

ProtoNet protein and cluster: P46109

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRKL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRKL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005207

Applied Biosystems Silencer® siRNAs for CRKL

Sigma-Aldrich siRNA and siRNA Panels for CRKL

Sigma-Aldrich shRNA for CRKL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRKL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005207
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005207
untagged cDNA clones in CMV expression vector (see all 2): NM_005207

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005207

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109

Function: May mediate the transduction of intracellular signals

Genatlas biochemistry entry for CRKL:

avian sarcoma virus CT10 (v-crk) related

15/18 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crkl) (see all 18 ):

	craniofacial	embryogenesis	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	hematopoietic system	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	nervous system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004713	protein tyrosine kinase activity	TAS	8361759
GO:0005070	SH3/SH2 adaptor activity	TAS	8798523
GO:0005515	protein binding	IPI	9788432 16284401

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for CRKL (Your Favorite Gene powered by Ingenuity) (see all 15 )

Integrin Signaling
Chronic Myeloid Leukemia Signaling
Actin Cytoskeleton Signaling
Ephrin Receptor Signaling
Leukocyte Extravasation Signaling

GeneDecks CRKL for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CRKL

5/112 Interacting proteins for CRKL (ENSP00000346300³ P46109^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 112 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP4K1	Q92918¹	STRING (score=.999) EBI-910, EBI-881
MAP4K5	Q9Y4K4¹	STRING (score=.943) EBI-910, EBI-1279
CBL	P22681²	STRING (score=.999) MINT-50722 MINT-15404
ERBB2	P04626²	STRING (score=.71) MINT-74502 MINT-74501
EGFR	P00533²	STRING (score=.892) MINT-61486

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0007242	intracellular signaling cascade	TAS	8361759
GO:0007254	JNK cascade	TAS	8798523
GO:0007265	Ras protein signal transduction	TAS	8798523
GO:0007389	pattern specification process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CRKL
8 Novoseek chemical compound relationships for CRKL gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	75.47	128	11443118 (6), 9845531 (4), 9886328 (4), 10204582 (4) (see all 57)
ifn-alpha	53.16	8	11167825 (4), 9872990 (1), 10428508 (1)
phosphatidylinositol	45.92	8	10531310 (1), 9092574 (1), 12589802 (1), 15556646 (1) (see all 7)
phosphotyrosine	19.32	3	9710592 (2), 10608804 (1)
threonine	8.64	2	9891069 (1), 10648385 (1)
proline	1.58	7	8978305 (3)
gtp	0.73	1	9268367 (1)
lipid	0.00	1	18314490 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRKL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRKL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005207

Sigma-Aldrich siRNA and siRNA Panels for CRKL

Sigma-Aldrich shRNA for CRKL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005207

REFSEQ mRNAs for CRKL gene:

NM_005207.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005207

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005207
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005207
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005207

Additional cDNA sequence:

AK000311.1 AK292909.1 AL049941.1 BC026248.1 BC033281.1 BC043500.1 BC044621.1 BC053958.1

CR456423.1 CR593236.1 CR625781.1 X59656.1

12 DOTS entries:

DT.100772973 DT.100724319 DT.92437776 DT.100020162 DT.95072289 DT.120668210 DT.318716 DT.120668414

DT.97803983 DT.120668411 DT.95233274 DT.92437779

24/362 AceView cDNA sequences (see all 362 ):

CR593236 AU100217 BX102236 CR625781 BM846172 BM473439 BU584826 N98279

BM695802 AA653436 AA854068 R11168 H88518 BQ720842 Z44120 BM561169

BC026248 AA991376 BX430572 AA481047 CF136322 BG681314 BX115757 CR456423

highest scoring ESTs for CRKL:

X59656 AA026051 AA031370 AA031371 AA043919 AA129594 AA129595 AA188510 AA317351 AA318007

Unigene Cluster for CRKL:

V-crk sarcoma virus CT10 oncogene homolog (avian)-like

Hs.592205 [show with all ESTs]

Unigene Representative Sequence: NM_005207

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000354336

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CRKL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRKL

¹ / ² / ³

7 probe-sets matching CRKL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
415_at²^{, 3}	U95-A	1	1.00	1.00	0.48	0.19	X59656	1.00	0.90	0.95	1
33524_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.67	X59656	1.00	0.90	0.95	1
35301_at²^{, 3}	U95-A	1	0.81	1.00	0.87	1.33	AL049941	0.80	1.00	0.91	1
206184_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005207	0.60	1.00	0.82	1
212180_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK000311	0.80	1.00	0.91	1
206184_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212180_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCTGTTTGT

SOURCE GeneReport for Unigene cluster: Hs.592205
Expression variation in blood from EXPOLDB for CRKL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRKL gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRKL¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	91.42(n) 93.07(a)	608125 XM_855230.1 XP_860323.1
chimpanzee (Pan troglodytes)	CRKL¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	97.3(n) 96.62(a)	470146 XM_001167996.1 XP_001167996.1
rat (Rattus norvegicus)	Crkl¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	91.53(n) 96.7(a)	287942 NM_001008284.1 NP_001008285.1
mouse (Mus musculus)	Crkl^{1, 5}	16⁵	v-crk sarcoma virus CT10 oncogene homolog (avian)-like^{1, 5}	90.54(n)¹ 96.7(a)¹	12929¹ NM_007764.3¹ NP_031790.2¹ AA589403⁵ AI325100⁵ (see all 19)
chicken (Gallus gallus)	CRKL¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	83.72(n) 92.69(a)	416939 XM_415233.2 XP_415233.1

About this table Species with no ortholog for CRKL

ENSEMBL Gene Tree for CRKL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CRKL gene

CRK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/311 NCBI SNPs in CRKL are shown (see all 311 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs737894^1,2	A,C,F,H,O	19634408(+)	`TTGACG/ATGGAA`	1	--	ut3¹		9		MN EU EA WA NA	922
	rs1548410^1,2	A,C,F,H	19634463(+)	`TCTGTC/TGTGTT`	1	--	ut3¹		14		MN EU EA WA NA	1416
	rs737895^1,2	A,C,F,H	19638235(+)	`AATCTC/GCCTCC`	1	--	ng3¹		10		EA NA MN EU WA	841
	rs1043235^1,2	A,C,F,H	19636400(+)	`TTCCAG/ACAGAG`	1	--	ut3¹		9		EA MN EU WA NA	1486
	rs1043242^1,2	A,C,F,H	19636743(+)	`CAGATG/ATGTGC`	1	--	ut3¹		14		EA MN EU WA NA	2736
	rs2285547^1,2	A,C,F,H	19637058(+)	`ATTGAT/CTGGTT`	1	--	ut3¹		7		EA MN EU WA	2244
	rs9613388^1,2	F,H	19635473(+)	`CTGAAG/TCCCAG`	1	--	ut3¹		4		EU EA WA	418
--	rs7288034^1,2	A,C	19600823(+)	`agcgaC/Gactcc`	1	--	ng5¹		0	--	--	--	--
	rs11913242^1,2	H	19635257(+)	`GTTTTA/TAAAAG`	1	--	ut3¹		4		EU EA WA	416
	rs3180409^1,2	H	19602493(+)	`AGATCC/TACTAC`	1	H/Y	mis¹ ese³		4		EU EA WA	406

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HapMap Linkage Disequilibrium images for CRKL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602007

7 Novoseek disease relationships for CRKL gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	77.73	15	7521685 (1), 7493940 (1), 9593259 (1), 9845531 (1) (see all 14)
leukemia	48.88	12	7521685 (2), 12393632 (2), 7545163 (1), 11245441 (1) (see all 9)
leukemogenesis	28.01	2	11245441 (2)
lymphoblastic leukemia acute	25.30	1	7521685 (1)
cancer	0.00	2	19091943 (1)
breast cancer	0.00	1	12006644 (1)
tumors	0.00	4	11245441 (2), 19091943 (1), 9374471 (1)

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(Possibly Related Articles in Doctor's Guide)
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ASCO: Two-Month Quantitative RT-PCR Predicts Cytogenetic Response for Imatinib-Treated Interferon-Resistant Chronic Phase CML

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/157 PubMed articles for CRKL gene (see all 157 ):

Isolation and chromosomal localization of CRKL, a human crk-like gene. (PubMed id 8361759)^{1, 2, 3, 4} ten Hoeve J.... Groffen J. (1993)
CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PubMed id 11443118)^{1, 3, 4} Arai A.... Miura O. (2001)
Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)^{1, 3, 4} Koval A.P....LeRoith D. (1998)
The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. (PubMed id 8798523)^{1, 2, 3} Senechal K....Sawyers C.L. (1996)
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)^{1, 3, 4} Nishihara H....Tanaka S. (2002)
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)^{1, 3, 4} Elly C....Liu Y.-C. (1999)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets. (PubMed id 9845531)^{1, 3} Ozaki K....Ikeda Y. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1399	HGNC: 2363	AceView: CRKL	Ensembl:ENSG00000099942	euGenes: HUgn1399
ECgene: CRKL	H-InvDB: CRKL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CRKL	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CRKL
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CRKL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CRKL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CRKL		Antibodies for CRKL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CRKL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CRKL)
	Antibodies (CRKL)
	Chimera RNAi (CRKL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CRKL

	Recombinant Proteins (CrkL)
	Antibodies (CrkL)

Search OriGene for CRKL

Search Tocris compounds for CRKL

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CRKL

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CRKL Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CRKL

Summaries
for CRKL

Genomic Location
for CRKL

Proteins
for CRKL

Protein Domains/
Families
for CRKL

Gene Function
for CRKL

Pathways & Interactions
for CRKL

Drugs & Compounds
for CRKL

Transcripts
for CRKL

Expression
for CRKL

Orthologs
for CRKL

Paralogs
for CRKL

SNPs/Variants
for CRKL

Disorders & Mutations
for CRKL

Medical News
for CRKL

Publications
for CRKL

Search for CRKL

Genome Databases showing CRKL

Other Databases showing CRKL

Specialized Databases showing CRKL

Licensable Technologies
for CRKL

Services
for CRKL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRKL Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CRKL

Summariesfor CRKL

Genomic Locationfor CRKL

Proteinsfor CRKL

Protein Domains/Familiesfor CRKL

Gene Functionfor CRKL

Pathways & Interactionsfor CRKL

Drugs & Compoundsfor CRKL

Transcriptsfor CRKL

Expression for CRKL

Orthologsfor CRKL

Paralogsfor CRKL

SNPs/Variantsfor CRKL

Disorders & Mutationsfor CRKL

Medical Newsfor CRKL

Publicationsfor CRKL

Search for CRKL

Genome Databases showing CRKL

Other Databases showing CRKL

Specialized Databases showing CRKL

Licensable Technologiesfor CRKL

Servicesfor CRKL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRKL

Summaries
for CRKL

Genomic Location
for CRKL

Proteins
for CRKL

Protein Domains/
Families
for CRKL

Gene Function
for CRKL

Pathways & Interactions
for CRKL

Drugs & Compounds
for CRKL

Transcripts
for CRKL

Expression
for CRKL

Orthologs
for CRKL

Paralogs
for CRKL

SNPs/Variants
for CRKL

Disorders & Mutations
for CRKL

Medical News
for CRKL

Publications
for CRKL

Licensable Technologies
for CRKL

Services
for CRKL