External Ids for CRKL Gene
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like) is a Protein Coding gene. Diseases associated with CRKL include distal 22q11.2 microdeletion syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include signal transducer activity and SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot for CRKL Gene
May mediate the transduction of intracellular signals