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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRKL Gene

protein-coding   GIFtS: 68
GCID: GC22P021272

v-crk sarcoma virus CT10 oncogene homolog (avian)-like

(Previous name: v-crk avian sarcoma virus CT10 oncogene homolog-like )
 Explore 22 diseases affiliated with
CRKL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRKL    

Aliases
for CRKL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like1 2
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like1
Crk-Like Protein2

External Ids:    HGNC: 23631   Entrez Gene: 13992   Ensembl: ENSG000000999427   OMIM: 6020075   UniProtKB: P461093   

Export aliases for CRKL gene to outside databases

Previous GC identifers: GC22P017970 GC22P019596 GC22P004539


Summaries
for CRKL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRKL:
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the
RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the
BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.(provided by
RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
Function: May mediate the transduction of intracellular signals

Gene Wiki entry for CRKL


Genomic Views
for CRKL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRKL gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   XBP-1   STAT1alpha   PPAR-alpha   AREB6   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CRKL promoter sequence
   Search SABiosciences Chromatin IP Primers for CRKL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRKL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

CRKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRKL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021272:  view genomic region     (about GC identifiers)

Start:
 21,271,714 bp from pter      End:
 21,308,037 bp from pter
Size:
 36,324 bases      Orientation:
 plus strand

Proteins
for CRKL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109 (See protein sequence)
Recommended Name: Crk-like protein  
Size: 303 amino acids; 33777 Da
Subunit: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4
6 PDB 3D structures from and Proteopedia for CRKL:
2BZX (3D)        2BZY (3D)        2DBK (3D)        2EO3 (3D)        2LQN (3D)        2LQW (3D)    
Secondary accessions: A8KA44 D3DX35

Explore the universe of human proteins at neXtProt for CRKL: NX_P46109

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46109

    • CRKL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005198.1  
    ENSEMBL proteins: 
     ENSP00000346300   ENSP00000396646  
    Reactome Protein details: P46109
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CRKL
    OriGene Protein Over-expression Lysate: CRKL
    OriGene Custom Protein Services for CRKL 
    GenScript Custom Purified and Recombinant Proteins Services for CRKL
    Novus Biologicals CRKL Proteins
    Novus Biologicals CRKL Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CRKL
    Uscn Proteins for CRKL

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    CRKL for ontologies           About GeneDecksing



    CRKL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRKL
    R&D Systems Antibodies for CRKL
    Cell Signaling Technology (CST) Antibodies for CRKL 
    OriGene Antibodies (see all 4): CRKL
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    GenScript Custom Superior Antibodies Services for CRKL
    Novus Biologicals CRKL Antibodies
    Abcam antibodies for CRKL 
    Uscn Antibodies for CRKL
    ThermoFisher Antibody for CRKL

    Assay Products for CRKL: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CRKL
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    Uscn ELISAs and CLIAs for CRKL

    Protein Domains /
    Families
    for CRKL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRKL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P46109

    ProtoNet protein and cluster: P46109

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
    Similarity: Belongs to the CRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Function
    for CRKL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
    Function: May mediate the transduction of intracellular signals

         Genatlas biochemistry entry for CRKL:
    avian sarcoma virus CT10 (v-crk) related

    miRNA
    Products:            		miRTarBase miRNAs that target CRKL:
    hsa-mir-107 (MIRT004697)

    OriGene 3'-UTR Clone: CRKL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRKL
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRKL (see all 7)
    OriGene shRNA RFP: CRKL
    OriGene siRNA: CRKL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRKL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CRKL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRKL (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRKL
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CRKL (NM_005207)
    Sino Biological Human cDNA Clone for CRKL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CRKL
    Search LifeMap BioReagents cell lines for CRKL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8798523
    GO:0005070SH3/SH2 adaptor activity TAS8798523
    GO:0005515protein binding IPI16284401


    CRKL for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CRKL:
     Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for CRKL: Crkltm1Hkp Crkltm1Imo
         15/16 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crkl) (see all 16):
     cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  hematopoietic system  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  skeleton  tumorigenesis 

    CRKL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRKL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/47 super-pathways (see all 47) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    		Development HGF signaling pathway1.00
    		Signaling of Hepatocyte Growth Factor Receptor0.35
    		Development_HGF signaling pathway0.78
    		Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23
    		Development_Neurotrophin family signaling0.45
    		Neurotrophin signaling pathway0.20
    		Development Neurotrophin family signaling0.45
    2Signaling by FGFR
    		Downstream signal transduction0.84
    		NGF signalling via TRKA from the plasma membrane0.70
    		Signaling by PDGF0.72
    		Signalling by NGF0.52
    3Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		IFN-gamma pathway0.43
    		Immune response IFN gamma signaling pathway1.00
    4Development_EPO-induced Jak-STAT pathway
    		Development EPO-induced Jak-STAT pathway1.00
    		EPO signaling pathway0.34
    		Development_EPO-induced Jak-STAT pathway1.00
    5G-protein signaling Rap1A regulation pathway
    		G-protein signaling Rap1A regulation pathway1.00
    		G-protein signaling_Rap1A regulation pathway0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/10 EMD Millipore Pathways for CRKL (see all 10)
        Development HGF signaling pathway
    Chemotaxis CXCR4 signaling pathway
    Immune response Role of DAP12 receptors in NK cells
    Development EPO-induced Jak-STAT pathway
    Development Flt3 signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRKL
        HGF Pathway
    Internalin Pathway
    Rap1 Pathway
    JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for CRKL
        Tyrosine Kinases / Adaptors

    5/10 GeneGo (Thomson Reuters) Pathways for CRKL (see all 10)
        Development EPO-induced MAPK pathway
    Development Neurotrophin family signaling
    Development Thrombopoietin-regulated cell processes
    Chemotaxis CXCR4 signaling pathway
    G-protein signaling Rap1A regulation pathway

    5/21 BioSystems Pathways for CRKL (see all 21) 
        EGFR1 Signaling Pathway
    MAPK signaling pathway
    IL-5 Signaling Pathway
    TCR Signaling Pathway
    Kit Receptor Signaling Pathway

    5/13        Reactome Pathways for CRKL (see all 13)
        Frs2-mediated activation
    Cytokine Signaling in Immune system
    Regulation of signaling by CBL
    NGF signalling via TRKA from the plasma membrane
    Downstream signal transduction


    5/13         Kegg Pathways  (Kegg details for CRKL) (see all 13):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Fc gamma R-mediated phagocytosis


    CRKL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRKL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for CRKL (P461091, 2, 3 ENSP000003463004) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422292, 3, ENSP000003412084MINT-8025839 MINT-8025854 I2D: score=6 STRING: ENSP00000341208
    CBLBQ131912, 3, ENSP000002641224MINT-8028115 MINT-8030520 I2D: score=5 STRING: ENSP00000264122
    ABL1P005192, 3, ENSP000003614234MINT-7213249 MINT-7213288 I2D: score=3 STRING: ENSP00000361423
    ERBB2P046262, 3, ENSP000002695714MINT-74502 MINT-74501 I2D: score=2 STRING: ENSP00000269571
    MAP4K1Q929181, 3, ENSP000003800664EBI-3451075,EBI-881 I2D: score=5 STRING: ENSP00000380066
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0007254JNK cascade TAS8798523
    GO:0007265Ras protein signal transduction TAS8798523
    GO:0007389pattern specification process ----
    GO:0007507heart development IEA--


    CRKL for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRKL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRKL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRKL
    10/11 Novoseek chemical compound relationships for CRKL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.7 129 11443118 (6), 9845531 (4), 9886328 (4), 10204582 (4) (see all 58)
    imatinib 71.5 12 16391854 (2), 14604282 (1), 16840200 (1), 17432977 (1) (see all 9)
    ifn-alpha 51.4 8 11167825 (4), 9872990 (1), 10428508 (1)
    guanine 44.8 7 10907644 (1), 18601892 (1), 10926930 (1), 9374471 (1) (see all 6)
    phosphatidylinositol 44.5 8 10531310 (1), 9092574 (1), 12589802 (1), 15556646 (1) (see all 7)
    phosphotyrosine 18.1 3 9710592 (2), 10608804 (1)
    threonine 6.97 2 9891069 (1), 10648385 (1)
    gtp 0 1 9268367 (1)
    lipid 0 1 18314490 (1)
    proline 0 7 8978305 (3)

    Search CenterWatch for drugs/clinical trials and news about CRKL 

    Transcripts
    for CRKL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRKL gene: 
    NM_005207.3  

    Unigene Cluster for CRKL:

    V-crk sarcoma virus CT10 oncogene homolog (avian)-like
    Hs.5613  [show with all ESTs]
    Unigene Representative Sequence: NM_005207
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354336(uc002ztf.2) ENST00000411769

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CRKL
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRKL
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRKL (see all 7)
    OriGene shRNA RFP: CRKL
    OriGene siRNA: CRKL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRKL
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRKL
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    GenScript: all cDNA clones in your preferred vector: CRKL (NM_005207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRKL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRKL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRKL

    Additional cDNA sequence: 

    AK000311.1 AK292909.1 AL049941.1 BC026248.1 BC033281.1 BC043500.1 BC044621.1 BC053958.1 
    CR456423.1 X59656.1 

    13 DOTS entries:

    DT.100772973  DT.100724319  DT.92437776  DT.100020162  DT.95072289  DT.120668210  DT.318716  DT.120668414 
    DT.97803983  DT.100669663  DT.120668411  DT.92437779  DT.95233274 

    24/362 AceView cDNA sequences (see all 362):

    R11168 AU100217 BC026248 BM695802 BC033281 AA653436 BX102236 BM479009 
    H88518 AA481047 AI097284 BU736426 BQ720842 BU584826 BM846172 BG681314 
    AI189325 BX115757 BM473439 CR593236 AA506759 CR625781 CB137311 BQ956918 

    GeneLoc Exon Structure


    Expression
    for CRKL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRKL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTGTTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CRKL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRKL

    SOURCE GeneReport for Unigene cluster: Hs.5613
        SABiosciences Expression via Pathway-Focused PCR Array including CRKL: 
              Focal Adhesions in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL

    Orthologs
    for CRKL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CRKL gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Crkl1 , 5 v-crk sarcoma virus CT10 oncogene homolog (avian)-like1, 5 90.54(n)1
    96.7(a)1    		   16 (10.82 cM)5
    129291  NM_007764.41  NP_031790.21 
     174519875 
    chicken
    (Gallus gallus)    		 Aves CRKL1 v-crk sarcoma virus CT10 oncogene homolog (avian)-like 83.72(n)
    92.69(a)    		   416939  XM_415233.3  XP_415233.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CRKL6
    --
    		 --
    		 75(a)
    62(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343417.1(24-779)
    GL343279.1(314148-318422)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU916209.12   -- 80.81(n)    BU916209.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056763.12   -- 75.78(n)    BC056763.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Crk3 myoblast fusion SH3/SH2 adaptor protein 44(a)   102B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ced-26
    		 Cell death abnormality protein 2
    		 32(a)
    		 1 → many
    		 IV(1597315-1601620)


    ENSEMBL Gene Tree for CRKL (if available)
    TreeFam Gene Tree for CRKL (if available) 

    Paralogs
    for CRKL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRKL gene
    CRK2  
    2 SIMAP similar genes for CRKL using alignment to 2 protein entries:     CRKL_HUMAN (see all proteins):
    CRK    SH3GL2

    CRKL for paralogs           About GeneDecksing



    Genomic Variants
    for CRKL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 NCBI SNPs in CRKL are shown (see all 722)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1884035231,2
    		--21269955(+) ACATAG/TCTGGG 1 -- us2k10--------
    rs1913772741,2
    		--21270068(+) AGGCCA/GGGCGC 1 -- us2k10--------
    rs1849805421,2
    		--21270102(+) GCACTC/TTGGGA 1 -- us2k10--------
    rs1905319661,2
    		--21270149(+) GACCAC/TCCCGG 1 -- us2k10--------
    rs348420261,2
    		C,F,--21270324(+) TGGGCC/GACAGA 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
    rs713171951,2
    		C--21270345(+) AAAAA-/ATCAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs45087061,2
    		C--21270449(+) cttgaG/Aatggg 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1472693681,2
    		--21270452(+) GAGATA/GGGGAA 1 -- us2k10--------
    rs1868185781,2
    		--21270488(+) GTTCCA/GCTGCA 1 -- us2k10--------
    rs1899487881,2
    		--21270531(+) TCAAAA/GACAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRKL (21271714 - 21308037 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CRKL: --
    Human Gene Mutation Database (HGMD): CRKL

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    Disorders / Diseases
    for CRKL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRKL for disorders           About GeneDecksing

    OMIM gene information: 602007    OMIM disorders: --

    20/22 diseases for CRKL (see all 22):    About MalaCards
    wiskott-aldrich syndrome    sarcoma    acute promyelocytic leukemia    myeloid leukemia
    acute lymphocytic leukemia    digeorge syndrome    chronic myeloid leukemia    lymphoblastic leukemia
    lymphocytic leukemia    leukemia    renal cell carcinoma    cblc
    squamous cell carcinoma    shigellosis    ovarian carcinoma    laryngitis
    influenza    lung cancer    carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CRKL:
    Leukemia

    7 Novoseek disease relationships for CRKL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 77.7 16 7521685 (1), 7493940 (1), 9593259 (1), 9845531 (1) (see all 15)
    leukemia 47.5 12 7521685 (2), 12393632 (2), 7545163 (1), 11245441 (1) (see all 9)
    leukemogenesis 26.4 2 11245441 (2)
    lymphoblastic leukemia acute 23.6 1 7521685 (1)
    breast cancer 0 1 12006644 (1)
    tumors 0 4 11245441 (2), 19091943 (1), 9374471 (1)
    cancer 0 2 19091943 (1)

    Human Genome Epidemiology (HuGE) Navigator: CRKL (3 documents)

    Export disorders for CRKL gene to outside databases

    Publications
    for CRKL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRKL gene, integrated from 9 sources (see all 205):
    (articles sorted by number of sources associating them with CRKL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal localization of CRKL, a human crk-like gene. (PubMed id 8361759)1, 2, 3, 9 ten Hoeve J.... Groffen J. (1993)
    2. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PubMed id 11443118)1, 2, 9 Arai A.... Miura O. (2001)
    3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 9 Koval A.P.... LeRoith D. (1998)
    4. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. (PubMed id 8798523)1, 3, 9 Senechal K....Sawyers C.L. (1996)
    5. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (2002)
    6. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)1, 2, 9 Elly C....Liu Y.-C. (1999)
    7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets. (PubMed id 9845531)1, 9 Ozaki K....Ikeda Y. (1998)

    External Searches for CRKL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRKL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1399 HGNC: 2363 AceView: CRKL Ensembl:ENSG00000099942 euGenes: HUgn1399
    ECgene: CRKL Kegg: 1399 H-InvDB: CRKL

    Other Databases showing CRKL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRKL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRKL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRKL Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CRKL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRKL gene:
    Search GeneIP for patents involving CRKL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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