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Aliases for CRKL Gene

Aliases for CRKL Gene

  • CRK Like Proto-Oncogene, Adaptor Protein 2 3 5
  • V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like 2

External Ids for CRKL Gene

Previous GeneCards Identifiers for CRKL Gene

  • GC22P017970
  • GC22P019596
  • GC22P021272
  • GC22P004539

Summaries for CRKL Gene

Entrez Gene Summary for CRKL Gene

  • This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

GeneCards Summary for CRKL Gene

CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid, Somatic. Among its related pathways are RET signaling and B cell receptor signaling pathway (KEGG). GO annotations related to this gene include poly(A) RNA binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRK.

UniProtKB/Swiss-Prot for CRKL Gene

  • May mediate the transduction of intracellular signals.

Gene Wiki entry for CRKL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRKL Gene

Genomics for CRKL Gene

Regulatory Elements for CRKL Gene

Enhancers for CRKL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020948 0.2 ENCODE 25.4 +35.9 35879 10.6 HDGF PKNOX1 MLX ARID4B FEZF1 YY1 FOS ZNF263 SP5 ZHX2 SERPIND1 CRKL SNAP29 PI4KA LZTR1 ABHD17AP4 BCRP2 PIR59902 GC22P020955
GH22F020939 0.6 ENCODE 12.5 +22.4 22369 0.5 YBX3 ETS2 KLF1 POLR2A ZBTB2 NFXL1 MLLT1 SUPT5H SERPIND1 CRKL AIFM3 LZTR1 PIR47432
GH22F020940 0.2 ENCODE 12.5 +23.4 23358 1.2 KLF1 SMARCA4 TBL1XR1 NR2F1 GLIS1 NR4A1 ZZZ3 ZIC2 AIFM3 LZTR1 CRKL SERPIND1 SCARF2 PIR47432
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CRKL on UCSC Golden Path with GeneCards custom track

Promoters for CRKL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000291953 1102 4201 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for CRKL Gene

20,917,398 bp from pter
20,953,749 bp from pter
36,352 bases
Plus strand

Genomic View for CRKL Gene

Genes around CRKL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRKL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRKL Gene

Proteins for CRKL Gene

  • Protein details for CRKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Crk-like protein
    Protein Accession:
    Secondary Accessions:
    • A8KA44
    • D3DX35

    Protein attributes for CRKL Gene

    303 amino acids
    Molecular mass:
    33777 Da
    Quaternary structure:
    • Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).

    Three dimensional structures from OCA and Proteopedia for CRKL Gene

neXtProt entry for CRKL Gene

Post-translational modifications for CRKL Gene

  • Ubiquitination at Lys 292
  • Modification sites at PhosphoSitePlus

Other Protein References for CRKL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRKL (CRKL)

No data available for DME Specific Peptides for CRKL Gene

Domains & Families for CRKL Gene

Gene Families for CRKL Gene

Protein Domains for CRKL Gene

Suggested Antigen Peptide Sequences for CRKL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SH2 domain.
  • Belongs to the CRK family.
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
  • Belongs to the CRK family.
genes like me logo Genes that share domains with CRKL: view

Function for CRKL Gene

Molecular function for CRKL Gene

GENATLAS Biochemistry:
avian sarcoma virus CT10 (v-crk) related
UniProtKB/Swiss-Prot Function:
May mediate the transduction of intracellular signals.

Gene Ontology (GO) - Molecular Function for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8361759
GO:0005070 SH3/SH2 adaptor activity TAS 8798523
GO:0005515 protein binding IPI 8626543
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with CRKL: view
genes like me logo Genes that share phenotypes with CRKL: view

Human Phenotype Ontology for CRKL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CRKL Gene

MGI Knock Outs for CRKL:

Animal Model Products

miRNA for CRKL Gene

miRTarBase miRNAs that target CRKL

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRKL

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRKL Gene

Localization for CRKL Gene

Subcellular locations from

Jensen Localization Image for CRKL Gene COMPARTMENTS Subcellular localization image for CRKL gene
Compartment Confidence
cytosol 5
extracellular 5
endosome 4
nucleus 3
plasma membrane 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRKL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRKL Gene

Pathways & Interactions for CRKL Gene

genes like me logo Genes that share pathways with CRKL: view

SIGNOR curated interactions for CRKL Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001568 blood vessel development IEA --
GO:0007254 JNK cascade TAS 8798523
GO:0007265 Ras protein signal transduction TAS 8798523
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with CRKL: view

Drugs & Compounds for CRKL Gene

(6) Drugs for CRKL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CRKL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRKL: view

Transcripts for CRKL Gene

mRNA/cDNA for CRKL Gene

Unigene Clusters for CRKL Gene

V-crk sarcoma virus CT10 oncogene homolog (avian)-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRKL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRKL Gene

No ASD Table

Relevant External Links for CRKL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRKL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRKL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRKL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRKL Gene

Protein tissue co-expression partners for CRKL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRKL Gene:


SOURCE GeneReport for Unigene cluster for CRKL Gene:

genes like me logo Genes that share expression patterns with CRKL: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRKL Gene

Orthologs for CRKL Gene

This gene was present in the common ancestor of animals.

Orthologs for CRKL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRKL 34 35
  • 99.78 (n)
(Canis familiaris)
Mammalia CRKL 34 35
  • 95.05 (n)
(Rattus norvegicus)
Mammalia Crkl 34
  • 91.53 (n)
(Ornithorhynchus anatinus)
Mammalia CRKL 35
  • 91 (a)
(Mus musculus)
Mammalia Crkl 34 16 35
  • 90.54 (n)
(Monodelphis domestica)
Mammalia CRKL 35
  • 89 (a)
(Bos Taurus)
Mammalia CRKL 35
  • 81 (a)
(Gallus gallus)
Aves CRKL 34 35
  • 83.72 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crkl 34
  • 76.44 (n)
(Danio rerio)
Actinopterygii crkl 34 35
  • 72.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Crk 36 35
  • 44 (a)
(Caenorhabditis elegans)
Secernentea ced-2 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6350 35
  • 50 (a)
Species where no ortholog for CRKL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRKL Gene

Gene Tree for CRKL (if available)
Gene Tree for CRKL (if available)

Paralogs for CRKL Gene

Paralogs for CRKL Gene

(2) SIMAP similar genes for CRKL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRKL: view

Variants for CRKL Gene

Sequence variations from dbSNP and Humsavar for CRKL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1043235 -- 20,952,112(+) TTCCA(A/G)CAGAG intron-variant, utr-variant-3-prime
rs1043242 -- 20,952,455(+) CAGAT(A/G)TGTGC intron-variant, utr-variant-3-prime
rs1043260 -- 20,953,303(+) CGGTG(C/T)GGACG nc-transcript-variant, utr-variant-3-prime
rs1043264 -- 20,953,304(+) GGTGT(A/G)GACGC nc-transcript-variant, utr-variant-3-prime
rs10660912 -- 20,916,629(+) AAGAA(-/AA/AAG/AAGAAAAG)AAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRKL Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv4484n100 CNV gain 25217958
dgv4485n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
dgv7994n54 CNV gain 21841781
esv2678175 CNV deletion 23128226
esv2763693 CNV gain 21179565
esv3647304 CNV loss 21293372
esv3647305 CNV gain 21293372
esv3893441 CNV gain+loss 25118596
nsv1056614 CNV loss 25217958
nsv1065617 CNV gain 25217958
nsv1066625 CNV gain 25217958
nsv1123578 CNV deletion 24896259
nsv436864 CNV insertion 17901297
nsv523162 CNV loss 19592680
nsv588305 CNV loss 21841781
nsv834140 CNV loss 17160897
nsv834141 CNV loss 17160897

Variation tolerance for CRKL Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRKL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRKL Gene

Disorders for CRKL Gene

MalaCards: The human disease database

(7) MalaCards diseases for CRKL Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 22q11.2 deletion syndrome, distal
  • chromosome 22q11.2 deletion syndrome distal
leukemia, chronic myeloid, somatic
  • leukemia, chronic myeloid
chromosome 6pter-p24 deletion syndrome
  • 6p subtelomeric deletion syndrome
  • connective and soft tissue neoplasm
agnathia-otocephaly complex
  • agnathia-holoprosencephaly-situs inversus syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CRKL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRKL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRKL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRKL Gene

Publications for CRKL Gene

  1. Isolation and chromosomal localization of CRKL, a human crk-like gene. (PMID: 8361759) ten Hoeve J. … Groffen J. (Oncogene 1993) 2 3 4 22 64
  2. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders M.A. … Basson M.D. (J. Biol. Chem. 2009) 3 4 22 64
  3. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PMID: 12393632) Nishihara H. … Tanaka S. (Blood 2002) 3 4 22 64
  4. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PMID: 11443118) Arai A. … Miura O. (J. Biol. Chem. 2001) 3 4 22 64
  5. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PMID: 10022120) Elly C. … Liu Y.-C. (Oncogene 1999) 3 4 22 64

Products for CRKL Gene

Sources for CRKL Gene

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