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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRKL Gene

protein-coding   GIFtS: 70
GCID: GC22P021272

V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like1 2
Crk-Like Protein2

External Ids:    HGNC: 23631   Entrez Gene: 13992   Ensembl: ENSG000000999427   OMIM: 6020075   UniProtKB: P461093   

Export aliases for CRKL gene to outside databases

Previous GC identifers: GC22P017970 GC22P019596 GC22P004539


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRKL Gene:
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate
the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate
of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be
oncogenic.(provided by RefSeq, Jan 2009)

GeneCards Summary for CRKL Gene: 
CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a protein-coding gene. Diseases associated with CRKL include chronic myeloid leukemia, and cblc, and among its related super-pathways are Development HGF signaling pathway and MAPK signaling pathway. GO annotations related to this gene include SH3/SH2 adaptor activity and signal transducer activity. An important paralog of this gene is CRK.

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
Function: May mediate the transduction of intracellular signals

Gene Wiki entry for CRKL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRKL gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   XBP-1   STAT1alpha   PPAR-alpha   AREB6   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CRKL promoter sequence
   Search SABiosciences Chromatin IP Primers for CRKL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRKL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

CRKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRKL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021272:  view genomic region     (about GC identifiers)

Start:
21,271,714 bp from pter      End:
21,308,037 bp from pter
Size:
36,324 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109 (See protein sequence)
Recommended Name: Crk-like protein  
Size: 303 amino acids; 33777 Da
Subunit: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4
6 PDB 3D structures from and Proteopedia for CRKL:
2BZX (3D)        2BZY (3D)        2DBK (3D)        2EO3 (3D)        2LQN (3D)        2LQW (3D)    
Secondary accessions: A8KA44 D3DX35

Explore the universe of human proteins at neXtProt for CRKL: NX_P46109

Explore proteomics data for CRKL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46109

  • CRKL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRKL Protein Expression
    REFSEQ proteins: NP_005198.1  
    ENSEMBL proteins: 
     ENSP00000346300   ENSP00000396646  
    Reactome Protein details: P46109
    Human Recombinant Protein Products for CRKL: 
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    OriGene MassSpec for CRKL 
    OriGene Custom Protein Services for CRKL
    GenScript Custom Purified and Recombinant Proteins Services for CRKL
    Novus Biologicals CRKL Proteins
    Novus Biologicals CRKL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRKL
    Cloud-Clone Corp. Proteins for CRKL 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS--
    GO:0005829cytosol TAS--

    CRKL for ontologies           About GeneDecksing



    CRKL Antibody Products: 
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    Novus Biologicals CRKL Antibodies
    Abcam antibodies for CRKL
    Cloud-Clone Corp. Antibodies for CRKL 
    ThermoFisher Antibody for CRKL
    LSBio Antibodies in human, mouse, rat for CRKL 

    Assay Products for CRKL: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CRKL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRKL 
    Cloud-Clone Corp. CLIAs for CRKL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P46109

    ProtoNet protein and cluster: P46109

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
    Similarity: Belongs to the CRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    CRKL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRKL_HUMAN, P46109
    Function: May mediate the transduction of intracellular signals

         Genatlas biochemistry entry for CRKL:
    avian sarcoma virus CT10 (v-crk) related

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8361759
    GO:0005070SH3/SH2 adaptor activity TAS8798523
    GO:0005515protein binding IPI16273093
         
    CRKL for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRKL:
     Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

         15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crkl) (see all 16):
     cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  hematopoietic system  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  skeleton  tumorigenesis 

    CRKL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRKL: Crkltm1Hkp Crkltm1Imo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRKL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRKL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRKL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRKL 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRKL:
    hsa-mir-107 (MIRT004697)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRKL
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRKL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRKL

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CRKL

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CRKL (NM_005207)
    Sino Biological Human cDNA Clone for CRKL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL
    Sirion Biotech Customized lentivirus for stable overexpression of CRKL 
                         Customized lentivirus expression plasmids for stable overexpression of CRKL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRKL
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRKL About   (see all 47)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development Neurotrophin family signaling0.45
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Neurotrophin signaling pathway0.36
    Renal cell carcinoma0.30
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43
    4Development EPO-induced Jak-STAT pathway
    Development EPO-induced Jak-STAT pathway0.42
    EPO signaling pathway0.34
    5Signaling events mediated by Stem cell factor receptor (c-Kit)
    Kit Receptor Signaling Pathway0.37
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for CRKL (see all 10)
        Development HGF signaling pathway
    Chemotaxis CXCR4 signaling pathway
    Immune response Role of DAP12 receptors in NK cells
    Development EPO-induced Jak-STAT pathway
    Development Flt3 signaling

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRKL
        HGF Pathway
    Internalin Pathway
    Rap1 Pathway
    JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for CRKL
        Tyrosine Kinases / Adaptors

    5/10 GeneGo (Thomson Reuters) Pathways for CRKL (see all 10)
        Development EPO-induced MAPK pathway
    Development Neurotrophin family signaling
    Development Thrombopoietin-regulated cell processes
    Chemotaxis CXCR4 signaling pathway
    G-protein signaling Rap1A regulation pathway

    5/22 BioSystems Pathways for CRKL (see all 22)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway
    TCR Signaling Pathway


    5/13        Reactome Pathways for CRKL (see all 13)
        Frs2-mediated activation
    Cytokine Signaling in Immune system
    Regulation of signaling by CBL
    NGF signalling via TRKA from the plasma membrane
    Downstream signal transduction


    5/14         Kegg Pathways  (Kegg details for CRKL) (see all 14):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    Focal adhesion
    Fc gamma R-mediated phagocytosis


    CRKL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRKL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/168 Interacting proteins for CRKL (P461091, 2, 3 ENSP000003463004) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AP422292, 3, ENSP000003412084MINT-8025839 MINT-8025854 I2D: score=6 STRING: ENSP00000341208
    CBLBQ131912, 3, ENSP000002641224MINT-8028115 MINT-8030520 I2D: score=5 STRING: ENSP00000264122
    ABL1P005192, 3, ENSP000003614234MINT-7213249 MINT-7213288 I2D: score=3 STRING: ENSP00000361423
    ERBB2P046262, 3, ENSP000002695714MINT-74502 MINT-74501 I2D: score=2 STRING: ENSP00000269571
    MAP4K1Q929181, 3, ENSP000003800664EBI-910,EBI-881 I2D: score=5 STRING: ENSP00000380066
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0001568blood vessel development IEA--
    GO:0007254JNK cascade TAS8798523
    GO:0007265Ras protein signal transduction TAS8798523
    GO:0007389pattern specification process ----

    CRKL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRKL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRKL

    10/11 Novoseek inferred chemical compound relationships for CRKL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.7 129 11443118 (6), 9845531 (4), 9886328 (4), 10204582 (4) (see all 58)
    imatinib 71.5 12 16391854 (2), 14604282 (1), 16840200 (1), 17432977 (1) (see all 9)
    ifn-alpha 51.4 8 11167825 (4), 9872990 (1), 10428508 (1)
    guanine 44.8 7 10907644 (1), 18601892 (1), 10926930 (1), 9374471 (1) (see all 6)
    phosphatidylinositol 44.5 8 10531310 (1), 9092574 (1), 12589802 (1), 15556646 (1) (see all 7)
    phosphotyrosine 18.1 3 9710592 (2), 10608804 (1)
    threonine 6.97 2 9891069 (1), 10648385 (1)
    gtp 0 1 9268367 (1)
    lipid 0 1 18314490 (1)
    proline 0 7 8978305 (3)

    Search CenterWatch for drugs/clinical trials and news about CRKL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRKL gene: 
    NM_005207.3  

    Unigene Cluster for CRKL:

    V-crk sarcoma virus CT10 oncogene homolog (avian)-like
    Hs.5613  [show with all ESTs]
    Unigene Representative Sequence: NM_005207
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354336(uc002ztf.2) ENST00000411769
    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRKL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRKL

    Additional mRNA sequence: 

    AK000311.1 AK292909.1 AL049941.1 BC026248.1 BC033281.1 BC043500.1 BC044621.1 BC053958.1 
    CR456423.1 X59656.1 

    13 DOTS entries:

    DT.100772973  DT.100724319  DT.92437776  DT.100020162  DT.95072289  DT.120668210  DT.318716  DT.120668414 
    DT.97803983  DT.100669663  DT.120668411  DT.95233274  DT.92437779 

    24/362 AceView cDNA sequences (see all 362):

    CR456423 BC026248 Z44120 BM695802 AA506759 AI097284 BM846172 AI244429 
    BM473439 AA854068 CR593236 BC033281 BX102236 AU100217 N98279 CB137311 
    BQ217301 BM561169 AA653436 BX115757 H88518 AA991376 AA481047 BU174417 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRKL expression in normal human tissues (normalized intensities)      CRKL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGTTTGT
    CRKL Expression
    About this image


    CRKL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Thalamus
             Ventral striatum   
     
     Blood (Hematopoietic System)
             neutrophils   

    See CRKL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRKL

    SOURCE GeneReport for Unigene cluster: Hs.5613
        SABiosciences Expression via Pathway-Focused PCR Array including CRKL: 
              Focal Adhesions in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRKL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRKL gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crkl1 , 5 v-crk sarcoma virus CT10 oncogene homolog (avian)-like1, 5 90.54(n)1
    96.7(a)1
      16 (10.82 cM)5
    129291  NM_007764.41  NP_031790.21 
     174519875 
    chicken
    (Gallus gallus)
    Aves CRKL1 v-crk sarcoma virus CT10 oncogene homolog (avian)-like 83.72(n)
    92.69(a)
      416939  XM_415233.3  XP_415233.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRKL6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343417.1(24-779)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU916209.12   -- 80.81(n)    BU916209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056763.12   -- 75.78(n)    BC056763.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crk3 myoblast fusion SH3/SH2 adaptor protein 44(a)   102B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ced-26
    Cell death abnormality protein 2
    31(a)
    1 → many
    IV(1597316-1601621)


    ENSEMBL Gene Tree for CRKL (if available)
    TreeFam Gene Tree for CRKL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRKL gene
    CRK2  
    2 SIMAP similar genes for CRKL using alignment to 2 protein entries:     CRKL_HUMAN (see all proteins):
    CRK    SH3GL2

    CRKL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/893 SNPs in CRKL are shown (see all 893)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884035231,2
    --5209241(+) ACATAG/TCTGGG 1 -- us2k10--------
    rs1913772741,2
    --5209354(+) AGGCCA/GGGCGC 1 -- us2k10--------
    rs1849805421,2
    --5209388(+) GCACTC/TTGGGA 1 -- us2k10--------
    rs1905319661,2
    --5209435(+) GACCAC/TCCCGG 1 -- us2k10--------
    rs348420261,2
    C,F--5209610(+) TGGGCC/GACAGA 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
    rs1472693681,2
    --5209738(+) GAGATA/GGGGAA 1 -- us2k10--------
    rs1868185781,2
    --5209774(+) GTTCCA/GCTGCA 1 -- us2k10--------
    rs1899487881,2
    --5209817(+) TCAAAA/GACAAA 1 -- us2k10--------
    rs1813547041,2
    --5210016(+) CTCGGG/TAGGCT 1 -- us2k10--------
    rs1434897701,2
    C--5210035(+) AGAATA/CGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRKL (21271714 - 21308037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CRKL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv834141CNV Loss17160897
    nsv834140CNV Loss17160897
    nsv523162CNV Loss19592680
    dgv4872n71CNV Loss21882294
    nsv914418CNV Gain21882294
    nsv914423CNV Gain21882294
    nsv914419CNV Gain21882294
    nsv914390CNV Gain21882294


    Human Gene Mutation Database (HGMD): CRKL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRKL
    DNA2.0 Custom Variant and Variant Library Synthesis for CRKL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602007    OMIM disorders: --

    20 diseases for CRKL:    About MalaCards
    chronic myeloid leukemia    cblc    shigellosis    acute lymphocytic leukemia
    digeorge syndrome    sarcoma    acute promyelocytic leukemia    wiskott-aldrich syndrome
    myeloid leukemia    laryngitis    influenza    leukemia
    lymphoblastic leukemia    renal cell carcinoma    pancreatic cancer    squamous cell carcinoma
    pancreatitis    lung cancer    gastric cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CRKL:
    Leukemia

    CRKL for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for CRKL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 77.7 16 7521685 (1), 7493940 (1), 9593259 (1), 9845531 (1) (see all 15)
    leukemia 47.5 12 7521685 (2), 12393632 (2), 7545163 (1), 11245441 (1) (see all 9)
    leukemogenesis 26.4 2 11245441 (2)
    lymphoblastic leukemia acute 23.6 1 7521685 (1)
    breast cancer 0 1 12006644 (1)
    tumors 0 4 11245441 (2), 19091943 (1), 9374471 (1)
    cancer 0 2 19091943 (1)

    Genetic Association Database (GAD): CRKL
    Human Genome Epidemiology (HuGE) Navigator: CRKL (3 documents)

    Export disorders for CRKL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRKL gene, integrated from 9 sources (see all 211):
    (articles sorted by number of sources associating them with CRKL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal localization of CRKL, a human crk-like gene. (PubMed id 8361759)1, 2, 3, 9 ten Hoeve J.... Groffen J. (1993)
    2. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PubMed id 11443118)1, 2, 9 Arai A.... Miura O. (2001)
    3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 9 Koval A.P.... LeRoith D. (1998)
    4. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. (PubMed id 8798523)1, 3, 9 Senechal K....Sawyers C.L. (1996)
    5. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (2002)
    6. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)1, 2, 9 Elly C....Liu Y.-C. (1999)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1399 HGNC: 2363 AceView: CRKL Ensembl:ENSG00000099942 euGenes: HUgn1399
    ECgene: CRKL Kegg: 1399 H-InvDB: CRKL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRKL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRKL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRKL gene:
    Search GeneIP for patents involving CRKL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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