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Aliases for CRKL Gene

Aliases for CRKL Gene

  • V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like 2 3

External Ids for CRKL Gene

Previous GeneCards Identifiers for CRKL Gene

  • GC22P017970
  • GC22P019596
  • GC22P021272
  • GC22P004539

Summaries for CRKL Gene

Entrez Gene Summary for CRKL Gene

  • This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

GeneCards Summary for CRKL Gene

CRKL (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like) is a Protein Coding gene. Diseases associated with CRKL include distal 22q11.2 microdeletion syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include signal transducer activity and SH3/SH2 adaptor activity. An important paralog of this gene is CRK.

UniProtKB/Swiss-Prot for CRKL Gene

  • May mediate the transduction of intracellular signals

Gene Wiki entry for CRKL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRKL Gene

Genomics for CRKL Gene

Regulatory Elements for CRKL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRKL Gene

20,917,426 bp from pter
20,953,749 bp from pter
36,324 bases
Plus strand

Genomic View for CRKL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRKL Gene

Proteins for CRKL Gene

  • Protein details for CRKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Crk-like protein
    Protein Accession:
    Secondary Accessions:
    • A8KA44
    • D3DX35

    Protein attributes for CRKL Gene

    303 amino acids
    Molecular mass:
    33777 Da
    Quaternary structure:
    • Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.

    Three dimensional structures from OCA and Proteopedia for CRKL Gene

neXtProt entry for CRKL Gene

Proteomics data for CRKL Gene at MOPED

Post-translational modifications for CRKL Gene

  • Ubiquitination at Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for CRKL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CRKL (CRKL)

No data available for DME Specific Peptides for CRKL Gene

Domains for CRKL Gene

Gene Families for CRKL Gene

  • SH2D :SH2 domain containing

Protein Domains for CRKL Gene

Suggested Antigen Peptide Sequences for CRKL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P46109
  • Contains 1 SH2 domain.
  • Contains 2 SH3 domains.
  • Belongs to the CRK family.
genes like me logo Genes that share domains with CRKL: view

Function for CRKL Gene

Molecular function for CRKL Gene

GENATLAS Biochemistry:
avian sarcoma virus CT10 (v-crk) related
UniProtKB/Swiss-Prot Function:
May mediate the transduction of intracellular signals

Gene Ontology (GO) - Molecular Function for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8361759
GO:0005070 SH3/SH2 adaptor activity TAS 8798523
GO:0005515 protein binding IPI 16273093
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CRKL: view
genes like me logo Genes that share phenotypes with CRKL: view

Animal Models for CRKL Gene

MGI Knock Outs for CRKL:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRKL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRKL Gene

Localization for CRKL Gene

Subcellular locations from

Jensen Localization Image for CRKL Gene COMPARTMENTS Subcellular localization image for CRKL gene
Compartment Confidence
cytosol 4
endosome 4
cytoskeleton 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRKL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRKL Gene

Pathways for CRKL Gene

genes like me logo Genes that share pathways with CRKL: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0001568 blood vessel development IEA --
GO:0007254 JNK cascade TAS 8798523
GO:0007265 Ras protein signal transduction TAS 8798523
GO:0007389 pattern specification process --
genes like me logo Genes that share ontologies with CRKL: view

Compounds for CRKL Gene

(11) Novoseek inferred chemical compound relationships for CRKL Gene

Compound -log(P) Hits PubMed IDs
tyrosine 74.7 104
imatinib 71.5 10
ifn-alpha 51.4 6
guanine 44.8 6
phosphatidylinositol 44.5 7
genes like me logo Genes that share compounds with CRKL: view

Transcripts for CRKL Gene

mRNA/cDNA for CRKL Gene

(362) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRKL Gene

V-crk sarcoma virus CT10 oncogene homolog (avian)-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRKL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRKL Gene

No ASD Table

Relevant External Links for CRKL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRKL Gene

mRNA expression in normal human tissues for CRKL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CRKL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRKL Gene

SOURCE GeneReport for Unigene cluster for CRKL Gene Hs.5613

genes like me logo Genes that share expressions with CRKL: view

Expression partners for CRKL Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRKL Gene

Orthologs for CRKL Gene

This gene was present in the common ancestor of animals.

Orthologs for CRKL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CRKL 35
  • 95.05 (n)
  • 97.36 (a)
  • 97 (a)
(Mus musculus)
Mammalia Crkl 35
  • 90.54 (n)
  • 96.7 (a)
Crkl 16
Crkl 36
  • 97 (a)
(Pan troglodytes)
Mammalia CRKL 35
  • 99.78 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Crkl 35
  • 91.53 (n)
  • 96.7 (a)
(Bos Taurus)
Mammalia CRKL 36
  • 81 (a)
(Monodelphis domestica)
Mammalia CRKL 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CRKL 36
  • 91 (a)
(Gallus gallus)
Aves CRKL 35
  • 83.72 (n)
  • 92.69 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crkl 35
  • 76.44 (n)
  • 86.22 (a)
(Danio rerio)
Actinopterygii crkl 35
  • 72.33 (n)
  • 84 (a)
crkl 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crk 37
  • 44 (a)
Crk 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea ced-2 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6350 36
  • 50 (a)
Species with no ortholog for CRKL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRKL Gene

Gene Tree for CRKL (if available)
Gene Tree for CRKL (if available)

Paralogs for CRKL Gene

Paralogs for CRKL Gene

Selected SIMAP similar genes for CRKL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CRKL: view

Variants for CRKL Gene

Sequence variations from dbSNP and Humsavar for CRKL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs737892 -- 20,918,446(+) TTCCC(C/T)CTCAC intron-variant
rs737893 -- 20,934,613(+) TCTTT(C/T)TTGTT intron-variant
rs737894 -- 20,950,120(+) TTGAC(A/G)TGGAA utr-variant-3-prime
rs929201 -- 20,917,542(+) TGCCT(C/T)GTGTG utr-variant-5-prime
rs929202 -- 20,920,050(+) GAGTT(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRKL Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914418 CNV Gain 21882294
nsv834140 CNV Loss 17160897
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
dgv4872n71 CNV Loss 21882294
nsv914423 CNV Gain 21882294

Relevant External Links for CRKL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRKL Gene

Disorders for CRKL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CRKL Gene in MalaCards »

(1) Diseases for CRKL Gene including...

(1) University of Copenhagen DISEASES for CRKL Gene

(7) Novoseek inferred disease relationships for CRKL Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 77.7 15
leukemia 47.5 11
leukemogenesis 26.4 2
lymphoblastic leukemia acute 23.6 1
breast cancer 0 1

Relevant External Links for CRKL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRKL: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CRKL Gene

Publications for CRKL Gene

  1. Isolation and chromosomal localization of CRKL, a human crk-like gene. (PMID: 8361759) ten Hoeve J. … Groffen J. (Oncogene 1993) 2 3 4 23
  2. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. (PMID: 8798523) Senechal K. … Sawyers C.L. (J. Biol. Chem. 1996) 2 3 23
  3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval A.P. … LeRoith D. (J. Biol. Chem. 1998) 3 4 23
  4. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PMID: 10022120) Elly C. … Liu Y.-C. (Oncogene 1999) 3 4 23
  5. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PMID: 11443118) Arai A. … Miura O. (J. Biol. Chem. 2001) 3 4 23

Products for CRKL Gene

  • Addgene plasmids for CRKL

Sources for CRKL Gene

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