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CRKL Gene

protein-coding   GIFtS: 70
GCID: GC22P021272

V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like

  See CRKL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like1 2
Crk-Like Protein2

External Ids:    HGNC: 23631   Entrez Gene: 13992   Ensembl: ENSG000000999427   OMIM: 6020075   UniProtKB: P461093   

Export aliases for CRKL gene to outside databases

Previous GC identifers: GC22P017970 GC22P019596 GC22P004539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRKL Gene:
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate
the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate
of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be
oncogenic.(provided by RefSeq, Jan 2009)

GeneCards Summary for CRKL Gene:
CRKL (v-crk avian sarcoma virus CT10 oncogene homolog-like) is a protein-coding gene. Diseases associated with CRKL include distal 22q11.2 microdeletion syndrome, and chronic myeloid leukemia. GO annotations related to this gene include SH3/SH2 adaptor activity and signal transducer activity. An important paralog of this gene is CRK.

UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
Function: May mediate the transduction of intracellular signals

Gene Wiki entry for CRKL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRKL gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   XBP-1   STAT1alpha   PPAR-alpha   AREB6   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CRKL promoter sequence
   Search Chromatin IP Primers for CRKL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRKL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

CRKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRKL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021272:  view genomic region     (about GC identifiers)

Start:
21,271,714 bp from pter      End:
21,308,037 bp from pter
Size:
36,324 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109 (See protein sequence)
Recommended Name: Crk-like protein  
Size: 303 amino acids; 33777 Da
Subunit: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4
6 PDB 3D structures from and Proteopedia for CRKL:
2BZX (3D)        2BZY (3D)        2DBK (3D)        2EO3 (3D)        2LQN (3D)        2LQW (3D)    
Secondary accessions: A8KA44 D3DX35

Explore the universe of human proteins at neXtProt for CRKL: NX_P46109

Explore proteomics data for CRKL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys292
  • Modification sites at PhosphoSitePlus

  • See CRKL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005198.1  
    ENSEMBL proteins: 
     ENSP00000346300   ENSP00000396646  
    Reactome Protein details: P46109

    CRKL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for CRKL
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    Novus Biologicals CRKL Proteins
    Novus Biologicals CRKL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CRKL
    Cloud-Clone Corp. Proteins for CRKL

     
    Search eBioscience for Proteins for CRKL 

     
    antibodies-online proteins for CRKL (14 products) 

     
    antibodies-online peptides for CRKL

    CRKL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRKL
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    Abcam antibodies for CRKL
    Cloud-Clone Corp. Antibodies for CRKL
    ThermoFisher Antibody for CRKL
    antibodies-online antibodies for CRKL (117 products) 

    CRKL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRKL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRKL
    Cloud-Clone Corp. CLIAs for CRKL
    Search eBioscience for ELISAs for CRKL 
    antibodies-online kits for CRKL (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P46109

    ProtoNet protein and cluster: P46109

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: CRKL_HUMAN, P46109
    Similarity: Belongs to the CRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    Find genes that share domains with CRKL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRKL_HUMAN, P46109
    Function: May mediate the transduction of intracellular signals

         Genatlas biochemistry entry for CRKL:
    avian sarcoma virus CT10 (v-crk) related

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8361759
    GO:0005070SH3/SH2 adaptor activity TAS8798523
    GO:0005515protein binding IPI16273093
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CRKL           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRKL:
     Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crkl) (see all 16):
     cardiovascular system  craniofacial  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  skeleton  tumorigenesis 

    Find genes that share phenotypes with CRKL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CRKL: Crkltm1Hkp Crkltm1Imo

       genOway: Develop your customized and physiologically relevant rodent model for CRKL

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRKL:
    hsa-mir-32-5p (MIRT028306), hsa-mir-98-5p (MIRT027796), hsa-let-7b-5p (MIRT032482), hsa-mir-16-5p (MIRT031998), hsa-mir-29a-3p (MIRT049982), hsa-mir-107 (MIRT004697), hsa-mir-23b-3p (MIRT046303), hsa-mir-425-5p (MIRT039301), hsa-mir-193b-5p (MIRT038006)

    Block miRNA regulation of human, mouse, rat CRKL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRKL
    Predesigned siRNA for gene silencing in human, mouse, rat CRKL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRKL

    Clone
    Products:
         
    OriGene clones in human, mouse for CRKL (see all 7)
    OriGene ORF clones in mouse, rat for CRKL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRKL (NM_005207)
    Sino Biological Human cDNA Clone for CRKL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRKL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL
    Addgene plasmids for CRKL 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRKL
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRKL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    cytoskeleton2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CRKL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRKL About   (see all 49)  
    See pathways by source

    SuperPathContained pathways About
    1Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Neurotrophin signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43
    4Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    5Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37


    Find genes that share SuperPaths with CRKL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRKL
        HGF Pathway
    Internalin Pathway
    Rap1 Pathway
    JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for CRKL
        Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for CRKL (see all 10)
        Development EPO-induced MAPK pathway
    Development Neurotrophin family signaling
    Development Thrombopoietin-regulated cell processes
    Chemotaxis CXCR4 signaling pathway
    G-protein signaling Rap1A regulation pathway

    Selected BioSystems Pathways for CRKL (see all 23)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    Interferon type I
    IL-5 Signaling Pathway
    Kit Receptor Signaling Pathway


    3 Reactome Pathways for CRKL
        Downstream signal transduction
    Frs2-mediated activation
    Regulation of signaling by CBL


    Selected Kegg Pathways  (Kegg details for CRKL) (see all 15):
        MAPK signaling pathway
    ErbB signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Array including CRKL: 
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRKL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRKL (P461091, 2, 3 ENSP000003463004) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226811, 2, 3, ENSP000002640334EBI-910,EBI-518228 MINT-8029738 MINT-50722 MINT-8028550 MINT-7103666 MINT-8028576 MINT-8036186 MINT-15404 I2D: score=5 STRING: ENSP00000264033
    ABL1P005191, 2, 3, ENSP000003614234EBI-910,EBI-375543 MINT-7213249 MINT-7213288 I2D: score=3 STRING: ENSP00000361423
    ERBB2P046261, 2, 3, ENSP000002695714EBI-910,EBI-641062 MINT-74502 MINT-74501 I2D: score=2 STRING: ENSP00000269571
    EGFRP005331, 2, 3, ENSP000002754934EBI-910,EBI-297353 MINT-61486 I2D: score=2 STRING: ENSP00000275493
    STAT5AP422292, 3, ENSP000003412084MINT-8025839 MINT-8025854 I2D: score=6 STRING: ENSP00000341208
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0001568blood vessel development IEA--
    GO:0007254JNK cascade TAS8798523
    GO:0007265Ras protein signal transduction TAS8798523
    GO:0007389pattern specification process ----

    Find genes that share ontologies with CRKL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRKL

    Selected Novoseek inferred chemical compound relationships for CRKL gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.7 129 11443118 (6), 9845531 (4), 9886328 (4), 10204582 (4) (see all 58)
    imatinib 71.5 12 16391854 (2), 14604282 (1), 16840200 (1), 17432977 (1) (see all 9)
    ifn-alpha 51.4 8 11167825 (4), 9872990 (1), 10428508 (1)
    guanine 44.8 7 10907644 (1), 18601892 (1), 10926930 (1), 9374471 (1) (see all 6)
    phosphatidylinositol 44.5 8 10531310 (1), 9092574 (1), 12589802 (1), 15556646 (1) (see all 7)
    phosphotyrosine 18.1 3 9710592 (2), 10608804 (1)
    threonine 6.97 2 9891069 (1), 10648385 (1)
    gtp 0 1 9268367 (1)
    lipid 0 1 18314490 (1)
    proline 0 7 8978305 (3)



    Find genes that share compounds with CRKL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRKL gene: 
    NM_005207.3  

    Unigene Cluster for CRKL:

    V-crk sarcoma virus CT10 oncogene homolog (avian)-like
    Hs.5613  [show with all ESTs]
    Unigene Representative Sequence: NM_005207
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354336(uc002ztf.2) ENST00000411769
    miRNA
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    Block miRNA regulation of human, mouse, rat CRKL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRKL (see all 93):
    hsa-miR-194* hsa-miR-3152-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-15a hsa-miR-128 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CRKL (NM_005207)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRKL
    Addgene plasmids for CRKL 
    Primer
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    OriGene qPCR primer pairs and template standards for CRKL
    OriGene qSTAR qPCR primer pairs in human, mouse for CRKL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRKL
      QuantiTect SYBR Green Assays in human, mouse, rat CRKL
      QuantiFast Probe-based Assays in human, mouse, rat CRKL

    Additional mRNA sequence: 

    AK000311.1 AK292909.1 AL049941.1 BC026248.1 BC033281.1 BC043500.1 BC044621.1 BC053958.1 
    CR456423.1 X59656.1 

    13 DOTS entries:

    DT.100772973  DT.100724319  DT.92437776  DT.100020162  DT.95072289  DT.120668210  DT.318716  DT.120668414 
    DT.97803983  DT.100669663  DT.120668411  DT.95233274  DT.92437779 

    Selected AceView cDNA sequences (see all 362):

    BG681314 CB137311 AI244429 BQ956918 Z44120 AI097284 AA378362 BU174417 
    AA481047 BX430572 BU584826 BX102236 BM846172 AA991376 BQ720842 R11168 
    AU100217 BM695802 H88518 CR625781 CR456423 BM473439 BC033281 AI189325 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRKL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGTTTGT
    CRKL Expression
    About this image


    CRKL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
    CRKL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRKL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5613
        Pathway & Disease-focused RT2 Profiler PCR Array including CRKL: 
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRKL
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    QuantiTect SYBR Green Assays in human, mouse, rat CRKL
    QuantiFast Probe-based Assays in human, mouse, rat CRKL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRKL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRKL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crkl1 , 5 v-crk sarcoma virus CT10 oncogene homolog (avian)-like1, 5 90.54(n)1
    96.7(a)1
      16 (10.82 cM)5
    129291  NM_007764.51  NP_031790.21 
     174519875 
    chicken
    (Gallus gallus)
    Aves CRKL1 v-crk sarcoma virus CT10 oncogene homolog-like 83.72(n)
    92.69(a)
      416939  XM_415233.4  XP_415233.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    many ↔ many
    GL343279.1(314148-318422)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU916209.12   -- 80.81(n)    BU916209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056763.12   -- 75.78(n)    BC056763.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crk3 myoblast fusion SH3/SH2 adaptor protein 44(a)   102B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ced-26
    Protein CED-2 (ced-2) mRNA, complete cds
    31(a)
    1 → many
    IV(1597316-1601621) WBGene00000416


    ENSEMBL Gene Tree for CRKL (if available)
    TreeFam Gene Tree for CRKL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRKL gene
    CRK2  
    2 SIMAP similar genes for CRKL using alignment to 2 protein entries:     CRKL_HUMAN (see all proteins):
    CRK    SH3GL2

    Find genes that share paralogs with CRKL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRKL (see all 893)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884035231,2
    --5209241(+) ACATAG/TCTGGG 1 -- us2k10--------
    rs1913772741,2
    --5209354(+) AGGCCA/GGGCGC 1 -- us2k10--------
    rs1849805421,2
    --5209388(+) GCACTC/TTGGGA 1 -- us2k10--------
    rs1905319661,2
    --5209435(+) GACCAC/TCCCGG 1 -- us2k10--------
    rs348420261,2
    C,F--5209610(+) TGGGCC/GACAGA 1 -- us2k14Minor allele frequency- G:0.38NA WA 8
    rs1472693681,2
    --5209738(+) GAGATA/GGGGAA 1 -- us2k10--------
    rs1868185781,2
    --5209774(+) GTTCCA/GCTGCA 1 -- us2k10--------
    rs1899487881,2
    --5209817(+) TCAAAA/GACAAA 1 -- us2k10--------
    rs1813547041,2
    --5210016(+) CTCGGG/TAGGCT 1 -- us2k10--------
    rs1434897701,2
    C--5210035(+) AGAATA/CGCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRKL (21271714 - 21308037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CRKL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv834141CNV Loss17160897
    nsv834140CNV Loss17160897
    nsv523162CNV Loss19592680
    dgv4872n71CNV Loss21882294
    nsv914418CNV Gain21882294
    nsv914423CNV Gain21882294
    nsv914419CNV Gain21882294
    nsv914390CNV Gain21882294

    Human Gene Mutation Database (HGMD): CRKL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRKL
    DNA2.0 Custom Variant and Variant Library Synthesis for CRKL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602007    OMIM disorders: --

    2 diseases for CRKL:    
    About MalaCards
    distal 22q11.2 microdeletion syndrome    chronic myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for CRKL:
    Leukemia

    Find genes that share disorders with CRKL           About GenesLikeMe

    7 Novoseek inferred disease relationships for CRKL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 77.7 16 7521685 (1), 7493940 (1), 9593259 (1), 9845531 (1) (see all 15)
    leukemia 47.5 12 7521685 (2), 12393632 (2), 7545163 (1), 11245441 (1) (see all 9)
    leukemogenesis 26.4 2 11245441 (2)
    lymphoblastic leukemia acute 23.6 1 7521685 (1)
    breast cancer 0 1 12006644 (1)
    tumors 0 4 11245441 (2), 19091943 (1), 9374471 (1)
    cancer 0 2 19091943 (1)

    Genetic Association Database (GAD): CRKL
    Human Genome Epidemiology (HuGE) Navigator: CRKL (3 documents)

    Export disorders for CRKL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRKL gene, integrated from 10 sources (see all 220):
    (articles sorted by number of sources associating them with CRKL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal localization of CRKL, a human crk-like gene. (PubMed id 8361759)1, 2, 3, 9 ten Hoeve J.... Groffen J. (Oncogene 1993)
    2. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. (PubMed id 11443118)1, 2, 9 Arai A.... Miura O. (J. Biol. Chem. 2001)
    3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 9 Koval A.P.... LeRoith D. (J. Biol. Chem. 1998)
    4. The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene. (PubMed id 8798523)1, 3, 9 Senechal K....Sawyers C.L. (J. Biol. Chem. 1996)
    5. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (Blood 2002)
    6. Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. (PubMed id 10022120)1, 2, 9 Elly C....Liu Y.-C. (Oncogene 1999)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1399 HGNC: 2363 AceView: CRKL Ensembl:ENSG00000099942 euGenes: HUgn1399
    ECgene: CRKL Kegg: 1399 H-InvDB: CRKL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRKL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRKL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRKL gene:
    Search GeneIP for patents involving CRKL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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