External Ids for CRKL Gene
Previous GeneCards Identifiers for CRKL Gene
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
GeneCards Summary for CRKL Gene
CRKL (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid, Somatic. Among its related pathways are Bacterial invasion of epithelial cells and Kit Receptor Signaling Pathway. GO annotations related to this gene include poly(A) RNA binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
UniProtKB/Swiss-Prot for CRKL Gene
May mediate the transduction of intracellular signals.