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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRK Gene

protein-coding GIFtS: 67
GCID: GC17M001323

v-crk sarcoma virus CT10 oncogene homolog (avian)

(Previous name: v-crk avian sarcoma virus CT10 oncogene homolog )

Explore 35 diseases affiliated with
CRK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)¹ ²
Proto-Oncogene C-Crk² ³
P38¹
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog¹
CRKII²
Adapter Molecule Crk²

External Ids:	HGNC: 2362¹	Entrez Gene: 1398²	Ensembl: ENSG00000167193⁷	OMIM: 164762⁵	UniProtKB: P46108³

Export aliases for CRK gene to outside databases

Previous GC identifers: GC17M001318 GC17M001659 GC17M001533 GC17M001534 GC17M001272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRK:

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The

product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling

pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.

The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal

SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different

isoforms with distinct biological activity have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than

Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent

manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May

regulate the EFNA5-EPHA3 signaling

Gene Wiki entry for CRK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRK gene promoter:
Max1 AP-1 ATF-2 c-Jun c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRK promoter sequence

Search SABiosciences Chromatin IP Primers for CRK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13

CRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRK gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M001323: view genomic region (about GC identifiers)

Start:	1,323,983 bp from pter	End:	1,366,456 bp from pter
Size:	42,474 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108 (See protein sequence)

Recommended Name: Adapter molecule crk

Size: 304 amino acids; 33831 Da

Subunit: Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts (via SH2 domain)

with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via SH2 domain)

with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with FLT1

(tyrosine-phosphorylated) (By similarity). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1.

Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the ligand

EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3

signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform Crk-II (via SH2

domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Part of a collagen

stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1. Interacts (via SH2

domain) with the 'Tyr-9' phosphorylated form of PDPK1

Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma

membrane upon cell adhesion (By similarity)

6/7 PDB 3D structures from and Proteopedia for CRK (see all 7):

1JU5 (3D)

2DVJ (3D)

2EYV (3D)

2EYW (3D)

2EYX (3D)

2EYY (3D)

Secondary accessions: A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0

Alternative splicing: 2 isoforms: P46108-1 P46108-2 (Contains a phosphoserine at position 194)

Explore the universe of human proteins at neXtProt for CRK: NX_P46108

Post-translational modifications:

Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT¹

Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and

SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the

SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway¹

Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in

the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form

(By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P46108

CRK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005197.3 NP_058431.2

ENSEMBL proteins:

ENSP00000381942 ENSP00000300574 ENSP00000459505

Reactome Protein details: P46108
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CRK Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CRK OriGene Protein Over-expression Lysate (see all 2): CRK OriGene Custom Protein Services for CRK
	GenScript Custom Purified and Recombinant Proteins Services for CRK
	Novus Biologicals CRK Proteins Novus Biologicals CRK Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CRK
	Uscn Proteins for CRK

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10748058
GO:0005737	cytoplasm	IC	11870224
GO:0005768	endosome	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--

CRK for ontologies About GeneDecksing

CRK Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CRK
	Cell Signaling Technology (CST) Antibodies for CRK
	OriGene Antibodies (see all 2): CRK OriGene Custom Antibody Services for CRK
	GenScript Custom Superior Antibodies Services for CRK
	Novus Biologicals CRK Antibodies
	Abcam antibodies for CRK
	Uscn Antibodies for CRK
	ThermoFisher Antibody for CRK

Assay Products for CRK:

	EMD Millipore Kits and Assays for the Analysis of CRK
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRK
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRK for domains About GeneDecksing

3 InterPro domains/families:

IPR001452 SH3_domain

IPR011511 SH3_2

IPR000980 SH2

Graphical View of Domain Structure for InterPro Entry P46108

ProtoNet protein and cluster: P46108

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Domain: The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain

appears to function as a positive regulator for transformation (By similarity)

Domain: The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB

Similarity: Belongs to the CRK family

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than

Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent

manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May

regulate the EFNA5-EPHA3 signaling

Genatlas biochemistry entry for CRK:

avian sarcoma virus CT10 (v-crk) homolog

miRNA Products:		miRTarBase miRNAs that target CRK: hsa-mir-126 (MIRT002993)

		OriGene 3'-UTR Clone (see all 2): CRK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRK
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CRK (see all 62):
		hsa-miR-302d hsa-miR-520e hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-628-3p hsa-miR-105 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: CRK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRK (see all 7) OriGene shRNA RFP: CRK OriGene siRNA: CRK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRK

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CRK

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRK (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRK (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRK (NM_005206)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRK

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRK
		Search LifeMap BioReagents cell lines for CRK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRK

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0019904	protein domain specific binding	--	--
GO:0030674	protein binding, bridging	--	--
GO:0042169	SH2 domain binding	IPI	9472046

CRK for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CRK:

Decreased focal adhesion (FA)

Weaker migration

Animal Models:
Mouse knock-out Crk^tm1.1Cur for CRK
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crk):

cardiovascular system	craniofacial	digestive/alimentary	growth/size	homeostasis/metabolism
mortality/aging	muscle	nervous system	normal	respiratory system

CRK for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/70 super-pathways (see all 70) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development FGFR signaling pathway

	Development FGFR signaling pathway	1.00			Development_Flt3 signaling	0.45
	Development_FGFR signaling pathway	0.98			Development Flt3 signaling	0.45

Development HGF signaling pathway

	Development_HGF signaling pathway	0.78			Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
	Signaling of Hepatocyte Growth Factor Receptor	0.35			Neurotrophin signaling pathway	0.20

Signaling by FGFR

	Downstream signal transduction	0.84			NGF signalling via TRKA from the plasma membrane	0.70
	Signaling by PDGF	0.72			Signalling by NGF	0.52

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66

Development_PDGF signaling via STATs and NF-kB

	Development_Angiopoietin - Tie2 signaling	0.38			Angiopoietin receptor Tie2-mediated signaling	0.11
	Development Angiopoietin - Tie2 signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for CRK (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Development Angiopoietin - Tie2 signaling
	Chemotaxis CXCR4 signaling pathway
	Cytoskeleton remodeling FAK signaling
	Signal transduction JNK pathway

1 R&D Systems Pathway for CRK

Adipocytokines & Insulin Signaling

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRK (see all 15)

	Chemokine Signaling
	IGF1R Signaling
	Paxillin Interactions
	CXCR4 Pathway
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for CRK

Tyrosine Kinases / Adaptors

5/8 GeneGo (Thomson Reuters) Pathways for CRK (see all 8)

	Chemotaxis CXCR4 signaling pathway
	Cell adhesion Integrin-mediated cell adhesion and migration
	Signal transduction JNK pathway
	Development HGF signaling pathway
	Development FGFR signaling pathway

5/34 BioSystems Pathways for CRK (see all 34)

	Integrin-mediated cell adhesion
	Focal Adhesion
	EGFR1 Signaling Pathway
	MAPK signaling pathway
	ErbB signaling pathway

5/25 Reactome Pathways for CRK (see all 25)

	Regulation of signaling by CBL
	Downstream signal transduction
	Signal attenuation
	Signal Transduction
	Signaling by PDGF

1 PharmGKB Pathway for CRK

VEGF Signaling Pathway

5/13 Kegg Pathways (Kegg details for CRK) (see all 13):

	MAPK signaling pathway
	ErbB signaling pathway
	Chemokine signaling pathway
	Focal adhesion
	Fc gamma R-mediated phagocytosis

CRK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRK

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/353 Interacting proteins for CRK (P46108^{1, 2, 3} ENSP00000300574⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 353)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRS4	O14654²^,³, ENSP00000361202⁴	MINT-8029160 MINT-8027919 MINT-8033822 MINT-8034333 MINT-8033807 MINT-8027934 MINT-8034348 MINT-8029175 I2D: score=3 STRING: ENSP00000361202
BCAR1	P56945¹^,²^,³, ENSP00000162330⁴	EBI-886,EBI-702093 MINT-6763936 MINT-7104340 MINT-7104448 I2D: score=7 STRING: ENSP00000162330
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74496 MINT-74497 I2D: score=4 STRING: ENSP00000275493
ZAP70	P43403²^,³, ENSP00000264972⁴	MINT-8035366 I2D: score=7 STRING: ENSP00000264972
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-8036825 I2D: score=6 STRING: ENSP00000361423

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000186	activation of MAPKK activity	TAS	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10748058
GO:0007596	blood coagulation	TAS	--
GO:0008286	insulin receptor signaling pathway	TAS	--
GO:0030168	platelet activation	TAS	--

CRK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRK
10/20 Novoseek chemical compound relationships for CRK gene (see all 20) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	78.3	147	12799422 (6), 9195921 (5), 18835194 (4), 8524328 (4) (see all 76)
phosphotyrosine	62.8	2	11695992 (1), 15525532 (1)
phosphatidylinositol	58.9	17	14640702 (2), 15581361 (2), 10531310 (1), 9837978 (1) (see all 13)
thiosemicarbazide	48.1	3	7531694 (2)
thiazolidinedione	38.8	2	15581362 (1), 14640702 (1)
k252a	37.1	1	10850658 (1)
guanine	36	7	18835194 (2), 10970810 (1), 7512734 (1), 8035825 (1)
phenylalanine	31.4	4	9546424 (1), 12799422 (1), 11316748 (1), 9564038 (1)
proline	25	4	11080615 (2), 12955086 (1)
gtp	24.6	3	12054111 (1), 9268367 (1), 12198159 (1)

Search CenterWatch for drugs/clinical trials and news about CRK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRK gene (2 alternative transcripts):

NM_005206.4 NM_016823.3

Unigene Cluster for CRK:

V-crk sarcoma virus CT10 oncogene homolog (avian)

Hs.461896 [show with all ESTs]

Unigene Representative Sequence: NM_016823

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398970 ENST00000300574(uc002fsl.3 uc002fsm.3) ENST00000574295

ENST00000572145

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CRK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRK
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CRK (see all 62):
		hsa-miR-302d hsa-miR-520e hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-628-3p hsa-miR-105 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: CRK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRK (see all 7) OriGene shRNA RFP: CRK OriGene siRNA: CRK
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		GenScript: all cDNA clones in your preferred vector (see all 2): CRK (NM_005206)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRK
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRK

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRK

Additional cDNA sequence:

AK095449.1 AK291060.1 BC001718.1 BC008506.1 BC009837.1 BT007277.1 D10656.1

9 DOTS entries:

DT.450328 DT.100721097 DT.100779280 DT.95171032 DT.86849048 DT.120966123 DT.100716778 DT.91751135

DT.91751133

24/68 AceView cDNA sequences (see all 68):

BF794728 BM313846 BI862427 AI090527 AI203558 BX116568 BQ054291 AA425067

BM714209 BQ051702 CF138637 BE079546 AL137345 AV700545 AV684422 AA778710

BM676597 AW069001 AB067523 BU552965 CA449507 BM352339 BQ643535 AK092149

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CRK About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:					-
SP2:

ECgene alternative splicing isoforms for CRK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGTATAT

About this image
See CRK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRK

SOURCE GeneReport for Unigene cluster: Hs.461896

SABiosciences Expression via Pathway-Focused PCR Arrays including CRK:

Cytoskeleton Regulators in human mouse rat

Focal Adhesions in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Cell Motility in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRK Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CRK
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CRK gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRK¹	v-crk sarcoma virus CT10 oncogene homolog (avian)	83.99(n) 85.2(a)		417553 NM_001007846.1 NP_001007847.1
lizard (Anolis carolinensis)	Reptilia	CRK⁶ --	--	79(a) 60(a)	1 ↔ 1 possible ortholog	AAWZ02040788(2801-5271) GL343279.1(314148-318422)
African clawed frog (Xenopus laevis)	Amphibia	MGC68492²	hypothetical protein MGC68492	81.73(n)		BC060379.1
zebrafish (Danio rerio)	Actinopterygii	crk¹	v-crk sarcoma virus CT10 oncogene homolog (avian)	69.51(n) 77.13(a)		445234 NM_001003628.1 NP_001003628.1
fruit fly (Drosophila melanogaster)	Insecta	Crk¹	CG1587-PA	51.25(n) 52.57(a)		43775 NM_166743.2 NP_726549.1
worm (Caenorhabditis elegans)	Secernentea	ced-2¹	Protein CED-2	44.87(n) 35(a)		176968 NM_067704.3 NP_500105.1

ENSEMBL Gene Tree for CRK (if available)
TreeFam Gene Tree for CRK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRK gene

CRKL²

6 SIMAP similar genes for CRK using alignment to 3 protein entries: CRK_HUMAN (see all proteins):

GRAPL CSK SHC3 CRKL GRAP2 SH3GL2

CRK for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for CRK
PGOHUM00000262349 PGOHUM00000237214 PGOHUM00000262361

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193151207^1,2		--	1324182(+)	`TCAAAC/TCATTA`	2	--	ds500¹		0	--	--	--	--
rs61762283^1,2	C,	--	1324198(-)	`AGTAAC/TATTTC`	2	--	ds500¹		2		NS	80
rs184388452^1,2		--	1324275(+)	`TTAACC/TATGTC`	2	--	ds500¹		0	--	--	--	--
rs189028582^1,2		--	1324382(+)	`CTTTTC/TTTTGG`	2	--	ds500¹		0	--	--	--	--
rs146628920^1,2	C,	--	1324394(+)	`AGACA-/CTTATA`	2	--	ds500¹		0	--	--	--	--
rs61762282^1,2	C,F,	--	1324397(-)	`TCTTAT/CAAGTG`	2	--	ds500¹		2		NS	80
rs15948^1,2	C,F,A,H,	--	1324417(-)	`CCTCAA/GGAAAT`	2	--	ds500¹ ese³		22		MN NS EA NA WA	2786
rs79864792^1,2	C,	--	1324428(+)	`GGCATA/TAACTG`	2	--	ds500¹		1		CSA	1
rs11652581^1,2	C,H	--	1324549(+)	`TATGAT/CGAAAA`	2	--	ds500¹ ese³		5		NS EA NA	406
rs200800532^1,2	C	--	1324564(+)	`CATTAA/CAAGCC`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRK (1323983 - 1366456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRK: --
Human Gene Mutation Database (HGMD): CRK

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRK

DNA2.0 Custom Variant and Variant Library Synthesis for CRK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRK for disorders           About GeneDecksing

OMIM gene information: 164762    OMIM disorders: --

20/35 diseases for CRK (see all 35):    About MalaCards

miller-dieker syndrome sarcoma wiskott-aldrich syndrome non-small cell lung carcinoma

multiple endocrine neoplasia avian influenza oral squamous cell carcinoma squamous cell carcinoma

myeloid leukemia synovial sarcoma papillary thyroid carcinoma chronic myeloid leukemia

renal cell carcinoma cblc pheochromocytoma lissencephaly

thyroid carcinoma shigellosis carcinoma lung carcinoma

1 disease from the University of Copenhagen DISEASES database for CRK:

Lissencephaly

9 Novoseek disease relationships for CRK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	14.9	1	8524328 (1)
carcinoma squamous cell	0	2	10595738 (1), 10970810 (1)
inflammation	0	2	15031492 (1), 14610286 (1)
breast cancer	0	4	20008144 (1), 12006644 (1)
pheochromocytoma	0	1	8321240 (1)
tumors	0	19	12970743 (4), 16491127 (1), 18602365 (1), 16849525 (1) (see all 5)
carcinoma	0	3	12955086 (1), 10618718 (1)
cancer	0	17	15831672 (3), 16491127 (2), 19350053 (2), 18602365 (1) (see all 7)
sarcoma	0	2	19737974 (1), 17210721 (1)

Human Genome Epidemiology (HuGE) Navigator: CRK (3 documents)
Tumor Gene Database (TGDB): CRK

Export disorders for CRK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRK gene, integrated from 9 sources (see all 349):
(articles sorted by number of sources associating them with CRK)

Utopia: connect your pdf to the dynamic
world of online information

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)^{1, 2, 9} Koval A.P.... LeRoith D. (1998)
Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PubMed id 10733900)^{1, 2, 9} Matsumoto T....Mori S. (2000)
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)^{1, 2, 9} Matsuda M.... Kurata T. (1996)
Two species of human CRK cDNA encode proteins with distinct biological activities. (PubMed id 1630456)^{1, 2, 9} Matsuda M.... Shibuya M. (1992)
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)^{1, 2} Voss M....Janssen O. (2009)
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)^{1, 2} Modzelewska K....Keely P.J. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. (PubMed id 12878163)^{1, 2} Lennartsson J....Ronnstrand L. (2003)
DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PubMed id 12628187)^{1, 2} Yajnik V....Haber D.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1398	HGNC: 2362	AceView: CRK.1	Ensembl:ENSG00000167193	euGenes: HUgn1398
ECgene: CRK	Kegg: 1398	H-InvDB: CRK

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRK	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CRK	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CRK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CRK gene:
Search GeneIP for patents involving CRK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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v-crk sarcoma virus CT10 oncogene homolog (avian)

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v-crk sarcoma virus CT10 oncogene homolog (avian)

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