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CRK Gene

protein-coding GIFtS: 66

GC17M001272

v-crk sarcoma virus CT10 oncogene homolog (avian)
(Previous name: v-crk avian sarcoma virus CT10 oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRKII ^²
p38 ^³

Descriptions
Adapter molecule crk ^³
avian sarcoma virus CT10 (v-crk) oncogene homolog ^²
v-crk avian sarcoma virus CT10 oncogene homolog ^¹, ²
v-crk sarcoma virus CT10 oncogene homolog ^²
v-crk sarcoma virus CT10 oncogene homolog (avian) ^²

External Ids
HGNC: 2362¹
Entrez Gene: 1398²
UniProtKB: P46108³
Ensembl: ENSG00000167193⁷

Search outside databases for aliases for CRK gene

Previous GC identifers: GC17M001318 GC17M001659 GC17M001533 GC17M001534

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CRK:

This gene encodes a member of an adapter protein family that binds to several

tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains

(src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic

proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The

N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas

the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative

transcripts encoding different isoforms with distinct biological activity have been described.

[provided by RefSeq]

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less

transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane

ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells

and cell motility via its interaction with DOCK1 and DOCK4

Gene Wiki entry for CRK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRK gene

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13

CRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M001272: (about GC identifiers)

Start:	1,272,190 bp from pter
End:	1,306,294 bp from pter
Size:	34,105 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108 (See protein sequence)

Recommended Name: Proto-oncogene C-crk

Size: 304 amino acids; 33831 Da

Subunit: Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts

with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine

phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as

EGFR, PDGFR and INSR via its SH2 domain (By similarity). Interacts with DOCK1 and DOCK4. Interacts

with SHB

Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated

to the plasma membrane upon cell adhesion (By similarity)

PDB structures from and Proteopedia :

1JU5 (3D)

2DVJ (3D)

2EYV (3D)

2EYW (3D)

2EYX (3D)

2EYY (3D)

2EYZ (3D)

Secondary accessions: Q96HJ0

Alternative splicing: 2 isoforms: P46108-1 P46108-2

Post-translational modifications:

Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form¹

Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association

with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of

phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk

signaling pathway¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_005197.3 NP_058431.2

ENSEMBL proteins:

ENSP00000381942 ENSP00000300574

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CRK Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Crk p38)
	Human Recombinant Proteins from Abnova (CRK)

OriGene Purified Recombinant Human Proteins (see all 2): CRK

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	10748058
GO:0005737	cytoplasm	TAS	10748058
GO:0005768	endosome	EXP	7806500
GO:0005829	cytosol	EXP	16284401
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for CRK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for CRK
	R&D Systems Antibodies for CRK
	Cell Signaling Technology (CST) Antibodies for CRK
	Antibodies from Abcam (Crk p38), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRK)
	Novus Biologicals Antibodies for CRK

Assays for CRK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P46108

ProtoNet protein and cluster: P46108

3 Blocks protein families:

IPB000980 SH2 domain signature

IPB001452 SH3 domain signature

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Domain: The C-terminal SH3 domain function as a negative modulator for transformation and the

N-terminal SH3 domain appears to function as a positive regulator for transformation (By

similarity)

Domain: The SH2 domain mediates interaction with SHB

Similarity: Contains 1 SH2 domain

Similarity: Contains 2 SH3 domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005206

Applied Biosystems Silencer® siRNAs for CRK

Sigma-Aldrich siRNA for CRK

Sigma-Aldrich shRNA for CRK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005206
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005206
untagged cDNA clones in CMV expression vector (see all 5): NM_005206

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016823

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108

Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less

transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane

ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells

and cell motility via its interaction with DOCK1 and DOCK4

Genatlas biochemistry entry for CRK:

avian sarcoma virus CT10 (v-crk) homolog

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crk):

	craniofacial	digestive/alimentary	growth/size	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	muscle	nervous system	normal
respiratory system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9788432 9819391 11278465 14657239 15886098 16713569 17474147
GO:0042169	SH2 domain binding	IPI	9472046
GO:0045309	protein phosphorylated amino acid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for CRK (Your Favorite Gene powered by Ingenuity) (see all 17 )

Insulin Receptor Signaling
SAPK/JNK Signaling
Leukocyte Extravasation Signaling
Ephrin Receptor Signaling
Chronic Myeloid Leukemia Signaling

GeneDecks CRK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CRK

5/278 Interacting proteins for CRK (ENSP00000300574³ P46108^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 278 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	STRING (score=.999) EBI-886, EBI-375543
ABL2	P42684¹	STRING (score=.992) EBI-886, EBI-1102694
ASAP1	Q9ULH1¹	STRING (score=.881) EBI-886, EBI-346622
DOCK1	Q14185¹	STRING (score=.999) EBI-886, EBI-446740
DOCK3	Q8IZD9¹	STRING (score=.8) EBI-886, EBI-1752361

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10748058
GO:0007242	intracellular signaling cascade	EXP	9069267
GO:0030036	actin cytoskeleton organization	TAS	10748058

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CRK
10/13 Novoseek chemical compound relationships for CRK gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	78.24	145	12799422 (6), 9195921 (5), 18835194 (4), 8524328 (4) (see all 74)
phosphotyrosine	63.52	2	11695992 (1), 15525532 (1)
phosphatidylinositol	60.00	17	14640702 (2), 15581361 (2), 10531310 (1), 9837978 (1) (see all 13)
phenylalanine	32.62	4	9546424 (1), 12799422 (1), 11316748 (1), 9564038 (1)
proline	26.45	4	11080615 (2), 12955086 (1)
gtp	25.69	3	12054111 (1), 9268367 (1), 12198159 (1)
threonine	25.31	1	9891069 (1)
sphingosine	13.56	1	9195921 (1)
phosphoinositide	11.12	1	15883038 (1)
atp	0.00	1	15634006 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005206

Sigma-Aldrich siRNA for CRK

Sigma-Aldrich shRNA for CRK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005206 NM_016823

REFSEQ mRNAs for CRK gene (2 alternative transcripts):

NM_005206.3 NM_016823.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005206 NM_016823

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005206
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005206
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_005206

Additional cDNA sequence:

AK291060.1 BC001718.1 BC008506.1 BC009837.1 BT007277.1 CR590790.1 CR600568.1 D10656.1

10 DOTS entries:

DT.450328 DT.100779280 DT.100721097 DT.95171032 DT.86849048 DT.120966123 DT.100716778 DT.91751135

DT.120966099 DT.91751133

24/68 AceView cDNA sequences (see all 68 ):

BI862427 BM313846 AI090527 AI203558 BF794728 AA625795 AB067523 CF138637

BE079546 BM005955 AK092149 AI190661 CK822353 AX747382 BM467173 AW183830

BU501498 AA425067 AW069001 AL137345 CA449507 AV684422 AI215115 BU552965

highest scoring ESTs for CRK:

D10656 AA852942 AI085745 AL552288 AU116937 AU125411 AU135266 AU138629 BC001718 BC008506

Unigene Cluster for CRK:

V-crk sarcoma virus CT10 oncogene homolog (avian)

Hs.638121 [show with all ESTs]

Unigene Representative Sequence: BC008506

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CRK

ExUns:	1	^	2a	·	2b	^	3a	·	3b
SP1:					-
SP2:

About this scheme

ECgene alternative splicing isoforms for CRK

2 Ensembl transcripts including schematic representations:

ENST00000398970 ENST00000300574

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRK

¹ / ² / ³

9 probe-sets matching CRK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38219_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.79	D10656	1.00	1.00	1.00	1
772_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.62	D10656	1.00	1.00	1.00	1
49090_at*²^{, 3}	U95-C	1	1.00	1.00	0.54	1.62	AA197018	0.40	1.00	0.76	1
202224_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF304695	0.40	1.00	0.76	1
202226_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016823	0.60	1.00	0.82	1
202225_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AW612311	0.40	1.00	0.76	1
202224_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202226_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202225_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATTTGGGGT

SOURCE GeneReport for Unigene cluster: Hs.638121

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRK gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CRK¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)	99.56(n) 99.32(a)	747142 XM_001154201.1 XP_001154201.1
cow (Bos taurus)	CRK¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)	98.14(n) 100(a)	512841 XM_590426.3 XP_590426.3
rat (Rattus norvegicus)	Crk¹	--	v-crk sarcoma virus CT10 oncogene homolog (avian)	96.05(n) 99.67(a)	54245 NM_019302.1 NP_062175.1
mouse (Mus musculus)	Crk^{1, 5}	11 (44.15 cM)⁵	v-crk sarcoma virus CT10 oncogene homolog (avian)^{1, 5}	96.16(n)¹ 99.67(a)¹	12928¹ NM_133656.2¹ NP_598417.2¹ AF239673⁵ AK028488⁵ (see all 29)
chicken (Gallus gallus)	CRK¹	--	v-crk sarcoma virus CT10 oncogene	83.99(n) 85.2(a)	417553 NM_001007846.1 NP_001007847.1

About this table Species with no ortholog for CRK

ENSEMBL Gene Tree for CRK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CRK gene

CRKL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/308 NCBI SNPs in CRK are shown (see all 308 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1083^1,2	C,F,H	1272047(-)	`AAGTAT/CGGAAT`	2	--	ng5¹ ese³		9		EU EA WA NA MN	750
	rs1041967^1,2	C,H	1287115(-)	`CTATTT/GGGACA`	2	W/L	mis¹		9		MN EU EA WA	996
--	rs12941624^1,2	C	1308163(+)	`aaaaaA/TaTATA`	2	--	ng3¹		0	--	--	--	--
--	rs11544140^1,2	H	1287121(-)	`AATACA/GCTATT`	2	H/R	mis¹		4		EU EA WA	406
--	rs7218819^1,2	C	1306430(+)	`GCCCTG/TCCCGG`	2	--	ng3¹		0	--	--	--	--
	rs2229075^1,2	A,C,F	1306113(-)	`GGGGGC/AGGTTG`	2	R/R	syn¹ ese³		1		MN	44
	rs2063187^1,2	A,C,F,H,O	1295739(+)	`TGTTTA/CGGACA`	2	--	int¹		10		MN EU EA WA NA	928
	rs11657524^1,2	A,C,F,H	1304873(+)	`TCTATC/GTATTC`	2	--	int¹		10		EA NA EU WA	818
	rs11655449^1,2	A,C,F,H	1274465(+)	`GCACAC/AGACCT`	2	--	int¹		8		EU EA WA	832
	rs8070640^1,2	A,C,F,H	1278556(+)	`GGACCA/GTATCA`	2	--	int¹		11		EU EA WA NA	980

About this table

HapMap Linkage Disequilibrium images for CRK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164762

9 Novoseek disease relationships for CRK gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	16.54	1	8524328 (1)
cancer	0.00	13	15831672 (3), 16491127 (2), 19350053 (2), 18602365 (1) (see all 5)
inflammation	0.00	2	15031492 (1), 14610286 (1)
carcinoma	0.00	3	12955086 (1), 10618718 (1)
breast cancer	0.00	1	12006644 (1)
pheochromocytoma	0.00	1	8321240 (1)
tumors	0.00	12	12970743 (4), 16491127 (1), 16849525 (1), 18602365 (1)
sarcoma	0.00	1	17210721 (1)
carcinoma squamous cell	0.00	2	10595738 (1), 10970810 (1)

About this table

Human Genome Epidemiology Navigator: CRK (1 document)
Tumor Gene Database: CRK

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/296 PubMed articles for CRK gene (see all 296 ):

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)^{1, 3, 4} Koval A.P....LeRoith D. (1998)
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)^{1, 3, 4} Matsuda M.... Kurata T. (1996)
Two species of human CRK cDNA encode proteins with distinct biological activities. (PubMed id 1630456)^{1, 3, 4} Matsuda M.... Shibuya M. (1992)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PubMed id 12628187)^{3, 4} Yajnik V....Haber D.A. (2003)
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. (PubMed id 12384576)^{3, 4} Donaldson L.W.... Forman-Kay J.D. (2002)
NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. (PubMed id 10964504)^{3, 4} Lu L.... Welsh M. (2000)
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. (PubMed id 8657152)^{3, 4} Hasegawa H.... Matsuda M. (1996)
CRK proto-oncogene maps to human chromosome band 17p13. (PubMed id 8378094)^{3, 4} Fioretos T.... Morris C. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1398	HGNC: 2362	AceView: CRK.1	Ensembl:ENSG00000167193	euGenes: HUgn1398
ECgene: CRK	H-InvDB: CRK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CRK	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CRK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CRK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CRK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CRK		Antibodies for CRK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CRK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CRK)
	Antibodies (CRK)
	Chimera RNAi (CRK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CRK

	Recombinant Proteins (Crk p38)
	Antibodies (Crk p38)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CRK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CRK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CRK Gene at Home site.
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CRK Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CRK

Summaries
for CRK

Genomic Location
for CRK

Proteins
for CRK

Protein Domains/
Families
for CRK

Gene Function
for CRK

Pathways & Interactions
for CRK

Drugs & Compounds
for CRK

Transcripts
for CRK

Expression
for CRK

Orthologs
for CRK

Paralogs
for CRK

SNPs/Variants
for CRK

Disorders & Mutations
for CRK

Medical News
for CRK

Publications
for CRK

Search for CRK

Genome Databases showing CRK

Other Databases showing CRK

Specialized Databases showing CRK

Licensable Technologies
for CRK

Services
for CRK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRK Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CRK

Summariesfor CRK

Genomic Locationfor CRK

Proteinsfor CRK

Protein Domains/Familiesfor CRK

Gene Functionfor CRK

Pathways & Interactionsfor CRK

Drugs & Compoundsfor CRK

Transcriptsfor CRK

Expression for CRK

Orthologsfor CRK

Paralogsfor CRK

SNPs/Variantsfor CRK

Disorders & Mutationsfor CRK

Medical Newsfor CRK

Publicationsfor CRK

Search for CRK

Genome Databases showing CRK

Other Databases showing CRK

Specialized Databases showing CRK

Licensable Technologiesfor CRK

Servicesfor CRK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRK

Summaries
for CRK

Genomic Location
for CRK

Proteins
for CRK

Protein Domains/
Families
for CRK

Gene Function
for CRK

Pathways & Interactions
for CRK

Drugs & Compounds
for CRK

Transcripts
for CRK

Expression
for CRK

Orthologs
for CRK

Paralogs
for CRK

SNPs/Variants
for CRK

Disorders & Mutations
for CRK

Medical News
for CRK

Publications
for CRK

Licensable Technologies
for CRK

Services
for CRK