Aliases for CRK Gene
External Ids for CRK Gene
Previous GeneCards Identifiers for CRK Gene
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRK Gene
CRK (V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog) is a Protein Coding gene. Diseases associated with CRK include Sarcoma and Chromosome 17P13.3 Duplication Syndrome. Among its related pathways are Bacterial invasion of epithelial cells and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include protein domain specific binding and SH3/SH2 adaptor activity. An important paralog of this gene is CRKL.
UniProtKB/Swiss-Prot for CRK Gene
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.