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CRK Gene

protein-coding   GIFtS: 69
GCID: GC17M001323

V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog1 2
Proto-Oncogene C-Crk2 3
p382 3
CRKII2
Adapter Molecule Crk2

External Ids:    HGNC: 23621   Entrez Gene: 13982   Ensembl: ENSG000001671937   OMIM: 1647625   UniProtKB: P461083   

Export aliases for CRK gene to outside databases

Previous GC identifers: GC17M001318 GC17M001659 GC17M001533 GC17M001534 GC17M001272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRK Gene:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins.
The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several
signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through
SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of
transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two
alternative transcripts encoding different isoforms with distinct biological activity have been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CRK Gene:
CRK (v-crk avian sarcoma virus CT10 oncogene homolog) is a protein-coding gene. Diseases associated with CRK include miller-dieker syndrome, and avian influenza. GO annotations related to this gene include SH3/SH2 adaptor activity and ephrin receptor binding. An important paralog of this gene is CRKL.

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108
Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity
than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a
Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with
DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling

Gene Wiki entry for CRK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  NT_187613.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRK gene promoter:
         Max1   AP-1   ATF-2   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRK promoter sequence
   Search Chromatin IP Primers for CRK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

CRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRK gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001323:  view genomic region     (about GC identifiers)

Start:
1,323,983 bp from pter      End:
1,366,456 bp from pter
Size:
42,474 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRK_HUMAN, P46108 (See protein sequence)
Recommended Name: Adapter molecule crk  
Size: 304 amino acids; 33831 Da
Subunit: Interacts with ABL1, C3G, DOCK3, MAP4K1, MAPK8 and SOS via its first SH3 domain. Interacts (via SH2
domain) with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 upon stimulus-induced tyrosine phosphorylation. Interacts (via
SH2 domain) with several tyrosine-phosphorylated growth factor receptors such as EGFR and INSR. Interacts with
FLT1 (tyrosine-phosphorylated). Interacts with DOCK1 and DOCK4. Interacts with SHB. Interacts with PEAK1.
Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3; upon activation of EPHA3 by the
ligand EFNA5 and EPHA3 tyrosine kinase activity-dependent. Interacts with EPHA3 (phosphorylated); mediates
EFNA5-EPHA3 signaling through RHOA GTPase activation. Interacts with FLT4 (tyrosine-phosphorylated). Isoform
Crk-II (via SH2 domain) interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated).
Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and p130cas/BCAR1.
Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1. Interacts with CBLC
Selected PDB 3D structures from and Proteopedia for CRK (see all 7):
1JU5 (3D)        2DVJ (3D)        2EYV (3D)        2EYW (3D)        2EYX (3D)        2EYY (3D)    
Secondary accessions: A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0
Alternative splicing: 2 isoforms:  P46108-1   P46108-2   (Contains a phosphoserine at position 194)

Explore the universe of human proteins at neXtProt for CRK: NX_P46108

Explore proteomics data for CRK at MOPED

Post-translational modifications: 

  • Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT1
  • Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and
    SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with
    the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway1
  • Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory
    conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated
    conformation in the trans form (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005197.3  NP_058431.2  

    ENSEMBL proteins: 
     ENSP00000381942   ENSP00000300574   ENSP00000459505  
    Reactome Protein details: P46108

    CRK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CRK Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CRK
    OriGene MassSpec for CRK
    OriGene Custom Protein Services for CRK
    GenScript Custom Purified and Recombinant Proteins Services for CRK
    Novus Biologicals CRK Proteins
    Novus Biologicals CRK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CRK
    Cloud-Clone Corp. Proteins for CRK

    CRK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRK
    R&D Systems Antibodies for CRK
    Cell Signaling Technology (CST) Antibodies for CRK 
    OriGene Antibodies for CRK
    OriGene Custom Antibody Services for CRK
    Novus Biologicals CRK Antibodies
    Abcam antibodies for CRK (Q96HJ0, Q96GA9, P46108)
    Cloud-Clone Corp. Antibodies for CRK
    ThermoFisher Antibody for CRK
    LSBio Antibodies in human, mouse, rat for CRK

    CRK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRK
    Cloud-Clone Corp. CLIAs for CRK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P46108

    ProtoNet protein and cluster: P46108

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: CRK_HUMAN, P46108
    Domain: The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3
    domain appears to function as a positive regulator for transformation (By similarity)
    Domain: The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB
    Similarity: Belongs to the CRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    CRK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRK_HUMAN, P46108
    Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity
    than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a
    Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with
    DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling

         Genatlas biochemistry entry for CRK:
    avian sarcoma virus CT10 (v-crk) homolog

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IEA--
    GO:0005515protein binding IPI10733900
    GO:0019904protein domain specific binding ----
    GO:0030674protein binding, bridging ----
    GO:0042169SH2 domain binding IPI9472046
         
    CRK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CRK:
     Decreased focal adhesion (FA)   Weaker migration 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crk):
     cardiovascular system  craniofacial  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  nervous system  normal  respiratory system 

    CRK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crktm1.1Cur for CRK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRK

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRK:
    hsa-mir-126-3p (MIRT002993), hsa-mir-125a-5p (MIRT021297), hsa-mir-15b-5p (MIRT046474), hsa-mir-129-1-3p (MIRT038706), hsa-mir-192-5p (MIRT026885), hsa-mir-215-5p (MIRT024820), hsa-mir-132-3p (MIRT007166), hsa-mir-10a-5p (MIRT025620), hsa-mir-1260b (MIRT052687), hsa-let-7e-5p (MIRT051574), hsa-mir-106b-3p (MIRT038548)

    Block miRNA regulation of human, mouse, rat CRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRK (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-628-3p hsa-miR-105 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidCRK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRK
    Predesigned siRNA for gene silencing in human, mouse, rat CRK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRK

    Clone
    Products:
         
    OriGene clones in human, mouse for CRK (see all 14)
    OriGene ORF clones in mouse, rat for CRK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRK (NM_005206)
    Sino Biological Human cDNA Clone for CRK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRK

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRK
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRK_HUMAN, P46108: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma
    membrane upon cell adhesion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10748058
    GO:0005737cytoplasm IC11870224
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CRK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRK About   (see all 69)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    Signaling of Hepatocyte Growth Factor Receptor0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CRK
        Adipocytokines & Insulin Signaling
    VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRK (see all 15)
        Chemokine Signaling
    IGF1R Signaling
    Paxillin Interactions
    CXCR4 Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for CRK
        Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for CRK (see all 8)
        Chemotaxis CXCR4 signaling pathway
    Cell adhesion Integrin-mediated cell adhesion and migration
    Signal transduction JNK pathway
    Development HGF signaling pathway
    Development FGFR signaling pathway

    Selected BioSystems Pathways for CRK (see all 34)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway
    Insulin Signaling


    Selected Reactome Pathways for CRK (see all 6)
        Downstream signal transduction
    ARMS-mediated activation
    Regulation of actin dynamics for phagocytic cup formation
    Signal attenuation
    Regulation of signaling by CBL

    1 PharmGKB Pathway for CRK
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for CRK) (see all 15):
        MAPK signaling pathway
    ErbB signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    Focal adhesion


    CRK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRK: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRK (P461081, 2, 3 ENSP000003005744) via UniProtKB, MINT, STRING, and/or I2D (see all 380)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRS4O146541, 2, 3, ENSP000003612024EBI-886,EBI-356594 MINT-8029160 MINT-8027919 MINT-8033822 MINT-8034333 MINT-8033807 MINT-8027934 MINT-8034348 MINT-8029175 I2D: score=3 STRING: ENSP00000361202
    BCAR1P569451, 2, 3, ENSP000001623304EBI-886,EBI-702093 MINT-6763936 MINT-7104340 MINT-7104448 I2D: score=7 STRING: ENSP00000162330
    EGFRP005331, 2, 3, ENSP000002754934EBI-886,EBI-297353 MINT-74496 MINT-74497 I2D: score=4 STRING: ENSP00000275493
    ABL1P005191, 2, 3, ENSP000003614234EBI-886,EBI-375543 MINT-8036825 I2D: score=6 STRING: ENSP00000361423
    ZAP70P434032, 3, ENSP000002649724MINT-8035366 I2D: score=7 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10748058
    GO:0007596blood coagulation TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0030168platelet activation TAS--

    CRK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRK

    Selected Novoseek inferred chemical compound relationships for CRK gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 78.3 147 12799422 (6), 9195921 (5), 18835194 (4), 8524328 (4) (see all 76)
    phosphotyrosine 62.8 2 11695992 (1), 15525532 (1)
    phosphatidylinositol 58.9 17 14640702 (2), 15581361 (2), 10531310 (1), 9837978 (1) (see all 13)
    thiosemicarbazide 48.1 3 7531694 (2)
    thiazolidinedione 38.8 2 15581362 (1), 14640702 (1)
    k252a 37.1 1 10850658 (1)
    guanine 36 7 18835194 (2), 10970810 (1), 7512734 (1), 8035825 (1)
    phenylalanine 31.4 4 9546424 (1), 12799422 (1), 11316748 (1), 9564038 (1)
    proline 25 4 11080615 (2), 12955086 (1)
    gtp 24.6 3 12054111 (1), 9268367 (1), 12198159 (1)



    CRK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRK gene (2 alternative transcripts): 
    NM_005206.4  NM_016823.3  

    Unigene Cluster for CRK:

    V-crk sarcoma virus CT10 oncogene homolog (avian)
    Hs.461896  [show with all ESTs]
    Unigene Representative Sequence: NM_016823
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398970 ENST00000300574(uc002fsl.3 uc002fsm.3) ENST00000574295
    ENST00000572145
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRK (see all 62):
    hsa-miR-302d hsa-miR-520e hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-628-3p hsa-miR-105 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidCRK 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRK (NM_005206)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRK
    Primer
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    OriGene qPCR primer pairs and template standards for CRK
    OriGene qSTAR qPCR primer pairs in human, mouse for CRK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRK
      QuantiTect SYBR Green Assays in human, mouse, rat CRK
      QuantiFast Probe-based Assays in human, mouse, rat CRK

    Additional mRNA sequence: 

    AK095449.1 AK291060.1 BC001718.1 BC008506.1 BC009837.1 BT007277.1 D10656.1 

    9 DOTS entries:

    DT.450328  DT.100721097  DT.100779280  DT.95171032  DT.86849048  DT.120966123  DT.100716778  DT.91751135 
    DT.91751133 

    Selected AceView cDNA sequences (see all 68):

    BF794728 AI203558 BI862427 AI090527 BM313846 CA778069 AW069001 CF138637 
    AA425067 BQ052326 AB067523 AX747382 AV698569 BX116568 BE079546 BU501498 
    BM352339 BQ054291 BM005955 AA778710 BQ653258 AL137345 CK822353 AV684422 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CRK    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for CRK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CRK expression in normal human tissues (normalized intensities)      CRK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTATAT
    CRK Expression
    About this image


    CRK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Cerebellum
    CRK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461896
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRK: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crk1 , 5 v-crk sarcoma virus CT10 oncogene homolog (avian)1, 5 96.16(n)1
    99.67(a)1
      11 (45.92 cM)5
    129281  NM_133656.51  NP_598417.21 
     756792595 
    chicken
    (Gallus gallus)
    Aves CRK1 v-crk sarcoma virus CT10 oncogene homolog 83.99(n)
    84.87(a)
      417553  NM_001007846.1  NP_001007847.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRK6
    v-crk avian sarcoma virus CT10 oncogene homolog
    79(a)
    1 ↔ 1
    AAWZ02040788(2801-5913)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684922 hypothetical protein MGC68492 81.73(n)    BC060379.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crk1 v-crk sarcoma virus CT10 oncogene homolog (avian) 69.4(n)
    76.45(a)
      445234  NM_001003628.2  NP_001003628.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crk1 Crk 51.25(n)
    52.57(a)
      43775  NM_166743.3  NP_726549.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ced-21 ced-2 45.51(n)
    35.38(a)
      176968  NM_067704.4  NP_500105.1 


    ENSEMBL Gene Tree for CRK (if available)
    TreeFam Gene Tree for CRK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRK gene
    CRKL2  
    6 SIMAP similar genes for CRK using alignment to 3 protein entries:     CRK_HUMAN (see all proteins):
    GRAPL    CSK    SHC3    CRKL    GRAP2    SH3GL2

    CRK for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CRK
    PGOHUM00000262349 PGOHUM00000237214 PGOHUM00000262361


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRK (see all 1033)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931512071,2
    --1315342(+) TCAAAC/TCATTA 2 -- ds50010--------
    rs617622831,2
    C,F--1315358(-) AGTAAC/TATTTC 2 -- ds50012Minor allele frequency- T:0.01NS 80
    rs1843884521,2
    --1315435(+) TTAACC/TATGTC 2 -- ds50010--------
    rs1890285821,2
    --1315542(+) CTTTTC/TTTTGG 2 -- ds50010--------
    rs1466289201,2
    C--1315554(+) AGACA-/CTTATA 2 -- ds50010--------
    rs617622821,2
    C,F--1315557(-) TCTTAT/CAAGTG 2 -- ds50012Minor allele frequency- C:0.04NS 80
    rs159481,2
    C,F,A,H--1315577(-) CCTCAA/GGAAAT 2 -- ds5001 ese322Minor allele frequency- G:0.12MN NS EA NA WA 2786
    rs798647921,2
    C--1315588(+) GGCATA/TAACTG 2 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs116525811,2
    C,H--1315709(+) TATGAT/CGAAAA 2 -- ds5001 ese35Minor allele frequency- C:0.00NS EA NA 406
    rs2008005321,2
    C--1315724(+) CATTAA/CAAGCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRK (1323983 - 1366456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CRK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715463CNV Deletion23290073
    esv1931977CNV Deletion18987734
    dgv3028n71CNV Loss21882294
    nsv833334CNV Loss17160897
    nsv470567CNV Gain18288195

    Human Gene Mutation Database (HGMD): CRK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRK
    DNA2.0 Custom Variant and Variant Library Synthesis for CRK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164762    OMIM disorders: --

    Selected diseases for CRK (see all 38):    About MalaCards
    miller-dieker syndrome    avian influenza    cblc    shigellosis
    synovial sarcoma    lissencephaly    sarcoma    multiple endocrine neoplasia
    chronic myeloid leukemia    influenza    pheochromocytoma    wiskott-aldrich syndrome
    papillary thyroid carcinoma    myeloid leukemia    lung adenocarcinoma    endometriosis
    oral squamous cell carcinoma    renal cell carcinoma    pancreatic cancer    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for CRK:
    Lissencephaly

    CRK for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for CRK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 14.9 1 8524328 (1)
    carcinoma squamous cell 0 2 10595738 (1), 10970810 (1)
    inflammation 0 2 15031492 (1), 14610286 (1)
    breast cancer 0 4 20008144 (1), 12006644 (1)
    pheochromocytoma 0 1 8321240 (1)
    tumors 0 19 12970743 (4), 16491127 (1), 18602365 (1), 16849525 (1) (see all 5)
    carcinoma 0 3 12955086 (1), 10618718 (1)
    cancer 0 17 15831672 (3), 16491127 (2), 19350053 (2), 18602365 (1) (see all 7)
    sarcoma 0 2 19737974 (1), 17210721 (1)

    Genetic Association Database (GAD): CRK
    Human Genome Epidemiology (HuGE) Navigator: CRK (3 documents)
    Tumor Gene Database (TGDB): CRK

    Export disorders for CRK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRK gene, integrated from 10 sources (see all 362):
    (articles sorted by number of sources associating them with CRK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 9 Koval A.P.... LeRoith D. (J. Biol. Chem. 1998)
    2. Differential interaction of CrkII adaptor protein with platelet- derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. (PubMed id 10733900)1, 2, 9 Matsumoto T.... Mori S. (Biochem. Biophys. Res. Commun. 2000)
    3. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)1, 2, 9 Matsuda M.... Kurata T. (J. Biol. Chem. 1996)
    4. Two species of human CRK cDNA encode proteins with distinct biological activities. (PubMed id 1630456)1, 2, 9 Matsuda M.... Shibuya M. (Mol. Cell. Biol. 1992)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    6. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    7. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. (PubMed id 17038317)1, 2 Modzelewska K.... Keely P.J. (J. Biol. Chem. 2006)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Identification of Tyr900 in the kinase domain of c-Kit as a Src- dependent phosphorylation site mediating interaction with c-Crk. (PubMed id 12878163)1, 2 Lennartsson J.... Ronnstrand L. (Exp. Cell Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1398 HGNC: 2362 AceView: CRK.1 Ensembl:ENSG00000167193 euGenes: HUgn1398
    ECgene: CRK Kegg: 1398 H-InvDB: CRK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRK gene:
    Search GeneIP for patents involving CRK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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