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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRISPLD2 Gene

protein-coding GIFtS: 48
GCID: GC16P084853

cysteine-rich secretory protein LCCL domain containing 2

(Previous name: LCCL domain containing cysteine-rich secretory protein...)
(Previous symbol: LCRISP2)

Explore 3 diseases affiliated with
CRISPLD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cysteine-Rich Secretory Protein LCCL Domain Containing 2¹ ²		CRISP11² ³
LCRISP2¹ ² ³		LCCL Domain-Containing Cysteine-Rich Secretory Protein 2² ³
LCCL Domain Containing Cysteine-Rich Secretory Protein 2¹ ²		DKFZP434B044¹
Cysteine-Rich Secretory Protein 11² ³		Cysteine-Rich Secretory Protein LCCL Domain-Containing 2²
CRISP-11² ³

External Ids:	HGNC: 25248¹	Entrez Gene: 83716²	Ensembl: ENSG00000103196⁷	OMIM: 612434⁵	UniProtKB: Q9H0B8³

Export aliases for CRISPLD2 gene to outside databases

Previous GC identifers: GC16P083412 GC16P070606

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8

Function: Promotes matrix assembly (By similarity)

Gene Wiki entry for CRISPLD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRISPLD2 gene promoter:
GR ER-alpha RP58 AP-1 RREB-1 HNF-4alpha1 FAC1 GR-alpha Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRISPLD2 promoter sequence

Search SABiosciences Chromatin IP Primers for CRISPLD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRISPLD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1

CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISPLD2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P084853: view genomic region (about GC identifiers)

Start:	84,853,587 bp from pter	End:	84,954,374 bp from pter
Size:	100,788 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8 (See protein sequence)

Recommended Name: Cysteine-rich secretory protein LCCL domain-containing 2 precursor

Size: 497 amino acids; 55920 Da

Subunit: Binds to heparin, dermatan sulfate and chondroitin sulfate (By similarity)

Subcellular location: Secreted (By similarity)

Secondary accessions: D3DUM0 Q6P590 Q6UWH0 Q6UXC6 Q96IB1 Q96K61

Alternative splicing: 5 isoforms: Q9H0B8-1 Q9H0B8-2 Q9H0B8-3 Q9H0B8-4 Q9H0B8-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRISPLD2: NX_Q9H0B8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H0B8

CRISPLD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_113664.1

ENSEMBL proteins:

ENSP00000262424 ENSP00000456554 ENSP00000457183 ENSP00000457655 ENSP00000454858

ENSP00000456952 ENSP00000457259 ENSP00000463171

Human Recombinant Protein Products:

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	Novus Biologicals CRISPLD2 Protein Novus Biologicals CRISPLD2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRISPLD2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0030133	transport vesicle	IDA	--
GO:0031012	extracellular matrix	IEA	--

CRISPLD2 for ontologies About GeneDecksing

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	Uscn Antibodies for CRISPLD2
	ThermoFisher Antibodies for CRISPLD2

Assay Products for CRISPLD2:

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	Uscn ELISAs and CLIAs for CRISPLD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRISPLD2 for domains About GeneDecksing

4 InterPro domains/families:

IPR014044 CAP_domain

IPR004043 LCCL

IPR001283 Allrgn_V5/Tpx1

IPR018244 Allrgn_V5/Tpx1_CS

Graphical View of Domain Structure for InterPro Entry Q9H0B8

ProtoNet protein and cluster: Q9H0B8

1 Blocks protein family: IPB001283 Allergen V5/Tpx-1 related

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8

Similarity: Belongs to the CRISP family

Similarity: Contains 2 LCCL domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8

Function: Promotes matrix assembly (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: CRISPLD2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRISPLD2
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CRISPLD2 (see all 27):
		hsa-miR-376b hsa-miR-4288 hsa-let-7a-2* hsa-miR-632 hsa-miR-548g hsa-miR-629* hsa-let-7g* hsa-miR-205*

		SwitchGear 3'UTR luciferase reporter plasmid: CRISPLD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRISPLD2 (see all 7) OriGene shRNA RFP: CRISPLD2 OriGene siRNA: CRISPLD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISPLD2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CRISPLD2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRISPLD2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRISPLD2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRISPLD2 (NM_031476)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRISPLD2
		Search LifeMap BioReagents cell lines for CRISPLD2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005539	glycosaminoglycan binding	--	--
GO:0008201	heparin binding	IEA	--

CRISPLD2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Crispld2^tm1Lex for CRISPLD2
     1 MGI phenotypic allele

for Crispld2 (no phenotypes)

CRISPLD2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRISPLD2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CRISPLD2 (ENSP00000262424⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IQCB1	ENSP00000311505⁴	STRING: ENSP00000311505

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030198	extracellular matrix organization	IEA	--

CRISPLD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRISPLD2
Search CenterWatch for drugs/clinical trials and news about CRISPLD2 / CRLD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRISPLD2 gene:

NM_031476.3

Unigene Cluster for CRISPLD2:

Cysteine-rich secretory protein LCCL domain containing 2

Hs.513779 [show with all ESTs]

Unigene Representative Sequence: NM_031476

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262424(uc010vog.1 uc010voh.1) ENST00000566151 ENST00000567845

ENST00000566431 ENST00000565561(uc002fik.4) ENST00000564567(uc002fin.4)

ENST00000569090(uc002fil.2) ENST00000569262(uc002fim.2) ENST00000563066

ENST00000566789 ENST00000566165

miRNA Products:		OriGene 3'-UTR Clone: CRISPLD2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRISPLD2
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CRISPLD2 (see all 27):
		hsa-miR-376b hsa-miR-4288 hsa-let-7a-2* hsa-miR-632 hsa-miR-548g hsa-miR-629* hsa-let-7g* hsa-miR-205*

		SwitchGear 3'UTR luciferase reporter plasmid: CRISPLD2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRISPLD2 (see all 7) OriGene shRNA RFP: CRISPLD2 OriGene siRNA: CRISPLD2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISPLD2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRISPLD2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRISPLD2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRISPLD2 (NM_031476)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISPLD2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISPLD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRISPLD2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRISPLD2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISPLD2

Additional cDNA sequence:

AK027395.1 AK056839.1 AK303887.1 AK308396.1 AL136861.1 AY358413.1 AY358790.1 BC007689.2

BC018643.2 BC063012.1

17 DOTS entries:

DT.87016965 DT.40231085 DT.100717151 DT.101980538 DT.102842928 DT.120675550 DT.91715453 DT.120675546

DT.95142384 DT.102842927 DT.120675573 DT.91693739 DT.92430479 DT.120675552 DT.75156532 DT.91936301

DT.95113684

24/175 AceView cDNA sequences (see all 175):

BM746891 BC007689 CR593410 AI470277 CR606278 AA905079 BF222666 BQ003508

AI581103 AI888021 BQ003613 BP345108 AI972383 AW074528 BE856161 BU734411

CR596827 AA954363 AI811893 AI087167 CA415056 CR591623 BX357067 BQ010162

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRISPLD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CRISPLD2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Primordial germ cell-like cells (Reconstitution of mo...)

See CRISPLD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRISPLD2

SOURCE GeneReport for Unigene cluster: Hs.513779

SABiosciences Custom PCR Arrays for CRISPLD2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRISPLD2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISPLD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRISPLD2 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CRISPLD2¹	cysteine-rich secretory protein LCCL domain containing 2 less	72.7(n) 73.64(a)		415818 XM_414180.3 XP_414180.2
lizard (Anolis carolinensis)	Reptilia	CRISPLD2⁶	--	70(a)	1 ↔ 1	GL343617.1(309789-334172)
zebrafish (Danio rerio)	Actinopterygii	LOC100535149¹	cysteine-rich secretory protein LCCL domain-containing 2-like less	65.57(n) 63.58(a)		100535149 XM_003199017.1 XP_003199065.1

ENSEMBL Gene Tree for CRISPLD2 (if available)
TreeFam Gene Tree for CRISPLD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRISPLD2 gene

CLEC18B² CLEC18C² PI16² GLIPR1² CRISP2² PI15² CRISP1² CRISPLD1²

CRISP3² GLIPR1L1² CLEC18A² GLIPR1L2² R3HDML²

4 SIMAP similar genes for CRISPLD2 using alignment to 6 protein entries: CRLD2_HUMAN (see all proteins):

PI15 R3HDML CRISPLD1 CLEC18A

CRISPLD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11860474^1,2	C,F,H,	--	84851590(+)	`AGTGGC/TTCGAT`	1	--	us2k¹		10		NS EA NA CSA WA	783
rs151152718^1,2		--	84851641(+)	`CCTCCC/TACCTC`	1	--	us2k¹		0	--	--	--	--
rs140176482^1,2		--	84851741(+)	`CTGAAC/TTCAAG`	1	--	us2k¹		0	--	--	--	--
rs145320895^1,2		--	84851786(+)	`CAGGCA/CTGAGC`	1	--	us2k¹		0	--	--	--	--
rs187739466^1,2		--	84851825(+)	`CTAACA/GCAGAT`	1	--	us2k¹		0	--	--	--	--
rs116527828^1,2	C,F,	--	84851846(+)	`CTTGGA/GTTTGT`	1	--	us2k¹		1		WA	118
rs72799541^1,2	C,F,	--	84851854(+)	`TGTCTT/GTTGTC`	1	--	us2k¹		1		NA	120
rs191383073^1,2		--	84851872(+)	`GGACTC/GTTGTT`	1	--	us2k¹		0	--	--	--	--
rs182141748^1,2		--	84851958(+)	`TGGATA/GACTGC`	1	--	us2k¹		0	--	--	--	--
rs186531313^1,2		--	84852026(+)	`AAAGAG/TGAAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRISPLD2 (84853587 - 84954374 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRISPLD2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRISPLD2

DNA2.0 Custom Variant and Variant Library Synthesis for CRISPLD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRISPLD2 for disorders           About GeneDecksing

OMIM gene information: 612434    OMIM disorders: --

3 diseases for CRISPLD2:    About MalaCards

cleft lip/palate cleft lip cleft palate

2 diseases from the University of Copenhagen DISEASES database for CRISPLD2:

Cleft lip Cleft palate

Human Genome Epidemiology (HuGE) Navigator: CRISPLD2 (10 documents)

Export disorders for CRISPLD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRISPLD2 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CRISPLD2)

Utopia: connect your pdf to the dynamic
world of online information

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
CRISPLD2: a novel NSCLP candidate gene. (PubMed id 17616516)^{1, 9} Chiquet B.T....Hecht J.T. (2007)
Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. (PubMed id 21254358)¹ Chiquet B.T....Hecht J.T. (2011)
The CRISPLD2 gene is involved in cleft lip and/or cle ft palate in a Chinese population. (PubMed id 21800413)¹ Shen X....Yu M. (2011)
No evidence for a role of CRISPLD2 in non-syndromic c left lip with or without cleft palate in an Italian population. (PubMed id 21244519)¹ Girardi A....Scapoli L. (2011)
CRISPLD2 polymorphisms are associated with non-syndro mic cleft lip with or without cleft palate in a northern Chinese population. (PubMed id 20662919)¹ Shi J....Cao F. (2010)
Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PubMed id 19937600)¹ Carter T.C....Mills J.L. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83716	HGNC: 25248	AceView: DKFZP434B044	Ensembl:ENSG00000103196	euGenes: HUgn83716
ECgene: CRISPLD2	H-InvDB: CRISPLD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CRISPLD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRISPLD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CRISPLD2 gene:
Search GeneIP for patents involving CRISPLD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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CRISPLD2 Gene

cysteine-rich secretory protein LCCL domain containing 2

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CRISPLD2 Gene

cysteine-rich secretory protein LCCL domain containing 2

Aliasesfor CRISPLD2 gene

Summariesfor CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

Expression
for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

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for CRISPLD2 gene

Intellectual Property
for CRISPLD2 gene

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for CRISPLD2 gene