Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CRISPLD2 Gene

protein-coding   GIFtS: 53
GCID: GC16P084853

Cysteine-Rich Secretory Protein LCCL Domain Containing 2

(Previous name: LCCL domain containing cysteine-rich secretory protein 2)
(Previous symbol: LCRISP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cysteine-Rich Secretory Protein LCCL Domain Containing 21 2     CRISP-112 3
LCRISP21 2 3     CRISP112 3
LCCL Domain Containing Cysteine-Rich Secretory Protein 21 2     LCCL Domain-Containing Cysteine-Rich Secretory Protein 22 3
Cysteine-Rich Secretory Protein 112 3     Cysteine-Rich Secretory Protein LCCL Domain-Containing 22

External Ids:    HGNC: 252481   Entrez Gene: 837162   Ensembl: ENSG000001031967   OMIM: 6124345   UniProtKB: Q9H0B83   

Export aliases for CRISPLD2 gene to outside databases

Previous GC identifers: GC16P083412 GC16P070606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CRISPLD2 Gene:
CRISPLD2 (cysteine-rich secretory protein LCCL domain containing 2) is a protein-coding gene. Diseases associated with CRISPLD2 include cleft lip +/- cleft palate, and cleft lip. GO annotations related to this gene include heparin binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8
Function: Promotes matrix assembly (By similarity)

Gene Wiki entry for CRISPLD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRISPLD2 gene promoter:
         GR   ER-alpha   RP58   AP-1   RREB-1   HNF-4alpha1   FAC1   GR-alpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISPLD2 promoter sequence
   Search Chromatin IP Primers for CRISPLD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISPLD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISPLD2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084853:  view genomic region     (about GC identifiers)

Start:
84,853,587 bp from pter      End:
84,954,374 bp from pter
Size:
100,788 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein LCCL domain-containing 2 precursor  
Size: 497 amino acids; 55920 Da
Subunit: Binds to heparin, dermatan sulfate and chondroitin sulfate (By similarity)
Secondary accessions: D3DUM0 Q6P590 Q6UWH0 Q6UXC6 Q96IB1 Q96K61
Alternative splicing: 5 isoforms:  Q9H0B8-1   Q9H0B8-2   Q9H0B8-3   Q9H0B8-4   Q9H0B8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRISPLD2: NX_Q9H0B8

Explore proteomics data for CRISPLD2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn27
  • Modification sites at PhosphoSitePlus

  • See CRISPLD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113664.1  
    ENSEMBL proteins: 
     ENSP00000262424   ENSP00000456554   ENSP00000457183   ENSP00000457655   ENSP00000454858  
     ENSP00000456952   ENSP00000457259   ENSP00000463171  

    CRISPLD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CRISPLD2
    OriGene Protein Over-expression Lysate for CRISPLD2
    OriGene MassSpec for CRISPLD2
    OriGene Custom Protein Services for CRISPLD2
    GenScript Custom Purified and Recombinant Proteins Services for CRISPLD2
    Novus Biologicals CRISPLD2 Protein
    Novus Biologicals CRISPLD2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRISPLD2

    CRISPLD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRISPLD2
    Novus Biologicals CRISPLD2 Antibodies
    Abcam antibodies for CRISPLD2
    Cloud-Clone Corp. Antibodies for CRISPLD2
    ThermoFisher Antibodies for CRISPLD2
    LSBio Antibodies in human, mouse, rat for CRISPLD2

    CRISPLD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRISPLD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRISPLD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRISPLD2
    Cloud-Clone Corp. CLIAs for CRISPLD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR014044 CAP_domain
     IPR004043 LCCL
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS

    Graphical View of Domain Structure for InterPro Entry Q9H0B8

    ProtoNet protein and cluster: Q9H0B8

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: CRLD2_HUMAN, Q9H0B8
    Similarity: Belongs to the CRISP family
    Similarity: Contains 2 LCCL domains
    Similarity: Contains 1 SCP domain


    CRISPLD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRLD2_HUMAN, Q9H0B8
    Function: Promotes matrix assembly (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005539glycosaminoglycan binding ----
    GO:0008201heparin binding IEA--
         
    CRISPLD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Crispld2 (no phenotypes)

    CRISPLD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crispld2tm1Lex for CRISPLD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISPLD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRISPLD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRISPLD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISPLD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRISPLD2:
    hsa-mir-335-5p (MIRT016863)

    Block miRNA regulation of human, mouse, rat CRISPLD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRISPLD2 (see all 27):
    hsa-miR-376b hsa-miR-4288 hsa-let-7a-2* hsa-miR-632 hsa-miR-548g hsa-miR-629* hsa-let-7g* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCRISPLD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRISPLD2
    Predesigned siRNA for gene silencing in human, mouse, rat CRISPLD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRISPLD2

    Clone
    Products:
         
    OriGene clones in human, mouse for CRISPLD2 (see all 7)
    OriGene ORF clones in mouse, rat for CRISPLD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRISPLD2 (NM_031476)
    Sino Biological Human cDNA Clone for CRISPLD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISPLD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISPLD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRISPLD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRISPLD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CRLD2_HUMAN, Q9H0B8: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030133transport vesicle IDA--
    GO:0031012extracellular matrix IEA--

    CRISPLD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRISPLD2
    Interactions:

        Search GeneGlobe Interaction Network for CRISPLD2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRISPLD2 (ENSP000002624244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQCB1ENSP000003115054STRING: ENSP00000311505
    KRTAP9-1ENSP000003814884STRING: ENSP00000381488
    CRIM1ENSP000002805274STRING: ENSP00000280527
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization IEA--
    GO:0030324lung development IEA--

    CRISPLD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRISPLD2 (CRLD2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CRISPLD2 gene: 
    NM_031476.3  

    Unigene Cluster for CRISPLD2:

    Cysteine-rich secretory protein LCCL domain containing 2
    Hs.513779  [show with all ESTs]
    Unigene Representative Sequence: NM_031476
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262424(uc010vog.1 uc010voh.1) ENST00000566151 ENST00000567845
    ENST00000566431 ENST00000565561(uc002fik.4) ENST00000564567(uc002fin.4)
    ENST00000569090(uc002fil.2) ENST00000569262(uc002fim.2) ENST00000563066
    ENST00000566789 ENST00000566165
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRISPLD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRISPLD2 (see all 27):
    hsa-miR-376b hsa-miR-4288 hsa-let-7a-2* hsa-miR-632 hsa-miR-548g hsa-miR-629* hsa-let-7g* hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCRISPLD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRISPLD2
    Predesigned siRNA for gene silencing in human, mouse, rat CRISPLD2
    Clone
    Products:
         
    OriGene clones in human, mouse for CRISPLD2 (see all 7)
    OriGene ORF clones in mouse, rat for CRISPLD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRISPLD2 (NM_031476)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISPLD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISPLD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRISPLD2
    OriGene qSTAR qPCR primer pairs in human, mouse for CRISPLD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISPLD2
      QuantiTect SYBR Green Assays in human, mouse, rat CRISPLD2
      QuantiFast Probe-based Assays in human, mouse, rat CRISPLD2

    Additional mRNA sequence: 

    AK027395.1 AK056839.1 AK303887.1 AK308396.1 AL136861.1 AY358413.1 AY358790.1 BC007689.2 
    BC018643.2 BC063012.1 

    17 DOTS entries:

    DT.87016965  DT.40231085  DT.100717151  DT.101980538  DT.102842928  DT.120675550  DT.91715453  DT.120675546 
    DT.95142384  DT.102842927  DT.120675573  DT.91693739  DT.92430479  DT.120675552  DT.75156532  DT.91936301 
    DT.95113684 

    Selected AceView cDNA sequences (see all 175):

    CA415056 AI620252 CR591623 AI468764 BM785441 BE315250 BQ003613 AI811893 
    AI972383 BQ010162 AA905079 AI470277 CR606278 BM046473 AI087167 BF222666 
    AI888021 BP345108 AK056839 AA954363 BQ006988 CR596827 BE856161 CR593410 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CRISPLD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRISPLD2 Expression
    About this image


    CRISPLD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
             Umbilical cord blood-derived mesenchymal stem cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
    CRISPLD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRISPLD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513779
        Custom PCR Arrays for CRISPLD2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRISPLD2
    OriGene qSTAR qPCR primer pairs in human, mouse for CRISPLD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISPLD2
    QuantiTect SYBR Green Assays in human, mouse, rat CRISPLD2
    QuantiFast Probe-based Assays in human, mouse, rat CRISPLD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CRISPLD2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crispld21 , 5 cysteine-rich secretory protein LCCL domain containing more1, 5 79.08(n)1
    77.94(a)1
      8 (68.76 cM)5
    788921  NM_030209.31  NP_084485.11 
     1199924385 
    chicken
    (Gallus gallus)
    Aves CRISPLD21 cysteine-rich secretory protein LCCL domain containing more 72.7(n)
    73.64(a)
      415818  XM_414180.4  XP_414180.2 
    lizard
    (Anolis carolinensis)
    Reptilia CRISPLD26
    cysteine-rich secretory protein LCCL domain contai...
    71(a)
    1 ↔ 1
    GL343617.1(309783-334245)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crispld21 cysteine-rich secretory protein LCCL domain containing more 67.95(n)
    70.3(a)
      613091  NM_001032328.1  NP_001027499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005351491 cysteine-rich secretory protein LCCL domain-containing more 66.25(n)
    64.39(a)
      100535149  XM_003199017.2  XP_003199065.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84836
    --
    27(a)
    1 → many
    3R(9034470-9040187)
    worm
    (Caenorhabditis elegans)
    Secernentea scl-236
    vap-16
    (see all 3)
    Protein SCL-23 (scl-23) mRNA, complete cds
    Protein VAP-1, isoform a (vap-1) mRNA, complete cd...
    (see all 3)
    19(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(86875-90082) WBGene00015246
    X(17393789-17396467) WBGene00006886


    ENSEMBL Gene Tree for CRISPLD2 (if available)
    TreeFam Gene Tree for CRISPLD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CRISPLD2 gene
    CLEC18B2  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    4 SIMAP similar genes for CRISPLD2 using alignment to 6 protein entries:     CRLD2_HUMAN (see all proteins):
    PI15    R3HDML    CRISPLD1    CLEC18A

    CRISPLD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CRISPLD2 (see all 3055)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118604741,2
    C,F,H--84851590(+) AGTGGC/TTCGAT 1 -- us2k110Minor allele frequency- T:0.13NS EA NA CSA WA 783
    rs1511527181,2
    --84851641(+) CCTCCC/TACCTC 1 -- us2k10--------
    rs1401764821,2
    --84851741(+) CTGAAC/TTCAAG 1 -- us2k10--------
    rs1453208951,2
    --84851786(+) CAGGCA/CTGAGC 1 -- us2k10--------
    rs1877394661,2
    --84851825(+) CTAACA/GCAGAT 1 -- us2k10--------
    rs1165278281,2
    C,F--84851846(+) CTTGGA/GTTTGT 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs727995411,2
    C,F--84851854(+) TGTCTT/GTTGTC 1 -- us2k11Minor allele frequency- G:0.05NA 120
    rs1913830731,2
    --84851872(+) GGACTC/GTTGTT 1 -- us2k10--------
    rs1821417481,2
    --84851958(+) TGGATA/GACTGC 1 -- us2k10--------
    rs1865313131,2
    --84852026(+) AAAGAG/TGAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRISPLD2 (84853587 - 84954374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CRISPLD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv457608CNV Loss19166990
    nsv457610CNV Loss19166990
    nsv907085CNV Gain21882294
    nsv907086CNV Gain21882294
    dgv2935n71CNV Gain21882294
    nsv457606CNV Gain19166990
    nsv907081CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISPLD2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISPLD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612434    OMIM disorders: --

    3 diseases for CRISPLD2:    
    About MalaCards
    cleft lip +/- cleft palate    cleft lip    cleft palate

    2 diseases from the University of Copenhagen DISEASES database for CRISPLD2:
    Cleft lip     Cleft palate

    CRISPLD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRISPLD2
    Human Genome Epidemiology (HuGE) Navigator: CRISPLD2 (10 documents)

    Export disorders for CRISPLD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CRISPLD2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CRISPLD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. CRISPLD2: a novel NSCLP candidate gene. (PubMed id 17616516)1, 4, 9 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2007)
    3. CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population. (PubMed id 20662919)1, 4 Shi J....Cao F. (Eur. J. Oral Sci. 2010)
    4. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PubMed id 19937600)1, 4 Carter T.C....Mills J.L. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. CRISPLD2 is expressed at low levels during septic shock and is associated with procalcitonin. (PubMed id 23799041)1 Wang T....Lin Z.F. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83716 HGNC: 25248 AceView: DKFZP434B044 Ensembl:ENSG00000103196 euGenes: HUgn83716
    ECgene: CRISPLD2 H-InvDB: CRISPLD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CRISPLD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CRISPLD2 gene:
    Search GeneIP for patents involving CRISPLD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CRISPLD2  
     OriGene qPCR primer pairs and template standards for CRISPLD2   OriGene Protein Over-expression Lysate for CRISPLD2  
     OriGene MassSpec something-or-other for CRISPLD2   OriGene clones in human, mouse for CRISPLD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRISPLD2   OriGene Purified Protein for CRISPLD2  
     OriGene ORF clones in mouse, rat for CRISPLD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRISPLD2   OriGene Custom Protein Services for CRISPLD2  

     
     
     Block miRNA regulation of human, mouse, rat CRISPLD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CRISPLD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISPLD2 Predesigned siRNA for gene silencing in human, mouse, rat CRISPLD2
     QuantiFast Probe-based Assays in human, mouse, rat CRISPLD2 QuantiTect SYBR Green Assays in human, mouse, rat CRISPLD2
     Custom PCR Arrays for CRISPLD2 Search Chromatin IP Primers for CRISPLD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISPLD2  Search GeneGlobe Interaction Network for CRISPLD2
     Regulatory tfbs in CRISPLD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CRISPLD2 GenScript cDNA clones with any tag delivered in your preferred vector for CRISPLD2
     GenScript Custom Assay Services for CRISPLD2 GenScript Custom overexpressing Cell Line Services for CRISPLD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CRISPLD2 (CRLD2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CRISPLD2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CRISPLD2 antibodies
     CRISPLD2 proteins
     CRISPLD2 lysates
     Antibodies for CRISPLD2
     See all of Abcam's Antibodies, Kits and Proteins for CRISPLD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CRISPLD2
     Antibodies for CRISPLD2
     ELISAs for CRISPLD2
     CLIAs for CRISPLD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CRISPLD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD2
     SwitchGear 3'UTR luciferase reporter plasmids for CRISPLD2
     SwitchGear Promoter luciferase reporter plasmids for CRISPLD2
     ThermoFisher Antibodies for CRISPLD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISPLD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISPLD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRISPLD2
     LSBio Antibodies in human, mouse, rat for CRISPLD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRISPLD2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4