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Aliases for CRISPLD2 Gene

Aliases for CRISPLD2 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 2 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 2 2 3
  • Cysteine-Rich Secretory Protein LCCL Domain Containing 2 3 5
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 2 3 4
  • Cysteine-Rich Secretory Protein 11 3 4
  • CRISP-11 3 4
  • LCRISP2 3 4
  • CRISP11 3 4
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Trypsin Inhibitor 3

External Ids for CRISPLD2 Gene

Previous HGNC Symbols for CRISPLD2 Gene

  • LCRISP2

Previous GeneCards Identifiers for CRISPLD2 Gene

  • GC16P083412
  • GC16P070606

Summaries for CRISPLD2 Gene

GeneCards Summary for CRISPLD2 Gene

CRISPLD2 (Cysteine Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CRISPLD2 Gene

  • Promotes matrix assembly.

Gene Wiki entry for CRISPLD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD2 Gene

Genomics for CRISPLD2 Gene

Regulatory Elements for CRISPLD2 Gene

Promoters for CRISPLD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRISPLD2 Gene

Chromosome:
16
Start:
84,819,981 bp from pter
End:
84,920,768 bp from pter
Size:
100,788 bases
Orientation:
Plus strand

Genomic View for CRISPLD2 Gene

Genes around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD2 Gene

Proteins for CRISPLD2 Gene

  • Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0B8-CRLD2_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Protein Accession:
    Q9H0B8
    Secondary Accessions:
    • D3DUM0
    • Q6P590
    • Q6UWH0
    • Q6UXC6
    • Q96IB1
    • Q96K61

    Protein attributes for CRISPLD2 Gene

    Size:
    497 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Binds to heparin, dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for CRISPLD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD2 Gene

Proteomics data for CRISPLD2 Gene at MOPED

Post-translational modifications for CRISPLD2 Gene

  • Glycosylation at Asn 27
  • Modification sites at PhosphoSitePlus

Other Protein References for CRISPLD2 Gene

Antibody Products

No data available for DME Specific Peptides for CRISPLD2 Gene

Domains & Families for CRISPLD2 Gene

Protein Domains for CRISPLD2 Gene

Suggested Antigen Peptide Sequences for CRISPLD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0B8

UniProtKB/Swiss-Prot:

CRLD2_HUMAN :
  • Contains 2 LCCL domains.
  • Belongs to the CRISP family.
Domain:
  • Contains 2 LCCL domains.
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD2: view

No data available for Gene Families for CRISPLD2 Gene

Function for CRISPLD2 Gene

Molecular function for CRISPLD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly.

Phenotypes for CRISPLD2 Gene

genes like me logo Genes that share phenotypes with CRISPLD2: view

Animal Models for CRISPLD2 Gene

MGI Knock Outs for CRISPLD2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISPLD2

CRISPR Products

miRNA for CRISPLD2 Gene

miRTarBase miRNAs that target CRISPLD2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISPLD2 Gene

Localization for CRISPLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISPLD2 Gene COMPARTMENTS Subcellular localization image for CRISPLD2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with CRISPLD2: view

Pathways & Interactions for CRISPLD2 Gene

SuperPathways for CRISPLD2 Gene

No Data Available

Interacting Proteins for CRISPLD2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262424%0d%0a9606.ENSP00000311505%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000221566%0d%0a9606.ENSP00000370395%0d%0a
Selected Interacting proteins: ENSP00000262424 for CRISPLD2 Gene via STRING

Gene Ontology (GO) - Biological Process for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with CRISPLD2: view

No data available for Pathways by source and SIGNOR curated interactions for CRISPLD2 Gene

Drugs & Compounds for CRISPLD2 Gene

No Compound Related Data Available

Transcripts for CRISPLD2 Gene

Unigene Clusters for CRISPLD2 Gene

Cysteine-rich secretory protein LCCL domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD2 Gene

No ASD Table

Relevant External Links for CRISPLD2 Gene

GeneLoc Exon Structure for
CRISPLD2
ECgene alternative splicing isoforms for
CRISPLD2

Expression for CRISPLD2 Gene

mRNA expression in normal human tissues for CRISPLD2 Gene

Protein differential expression in normal tissues from HIPED for CRISPLD2 Gene

This gene is overexpressed in Lavage (57.7) and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRISPLD2 Gene



SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene Hs.513779

genes like me logo Genes that share expression patterns with CRISPLD2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CRISPLD2 Gene

Orthologs for CRISPLD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRISPLD2 35
  • 84.41 (n)
  • 83.87 (a)
CRISPLD2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRISPLD2 35
  • 86.46 (n)
  • 89.17 (a)
CRISPLD2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crispld2 35
  • 79.08 (n)
  • 77.94 (a)
Crispld2 16
Crispld2 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD2 35
  • 99.26 (n)
  • 99.8 (a)
CRISPLD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crispld2 35
  • 79.48 (n)
  • 79.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CRISPLD2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD2 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRISPLD2 35
  • 72.7 (n)
  • 73.64 (a)
CRISPLD2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRISPLD2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld2 35
  • 67.95 (n)
  • 70.3 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535149 35
  • 66.25 (n)
  • 64.39 (a)
CRISPLD2 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 17 (a)
ManyToMany
scl-23 36
  • 19 (a)
ManyToMany
vap-1 36
  • 18 (a)
ManyToMany
Species with no ortholog for CRISPLD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD2 Gene

ENSEMBL:
Gene Tree for CRISPLD2 (if available)
TreeFam:
Gene Tree for CRISPLD2 (if available)

Paralogs for CRISPLD2 Gene

(4) SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CRISPLD2: view

Variants for CRISPLD2 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12051468 - 84,845,858(+) CCACC(A/G)GTCTG reference, missense
rs721005 - 84,872,492(+) TGGAA(C/G)TCTGT reference, missense
VAR_074672 -
rs2485 -- 84,909,443(+) CTAAA(A/T)TGTTC utr-variant-3-prime
rs3042 -- 84,848,409(+) TGCTG(C/G)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD2 Gene

Variant ID Type Subtype PubMed ID
nsv907081 CNV Gain 21882294
nsv457606 CNV Gain 19166990
dgv2935n71 CNV Gain 21882294
nsv457608 CNV Loss 19166990
nsv907085 CNV Gain 21882294
nsv907086 CNV Gain 21882294
nsv457610 CNV Loss 19166990

Variation tolerance for CRISPLD2 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISPLD2 Gene

HapMap Linkage Disequilibrium report
CRISPLD2
Human Gene Mutation Database (HGMD)
CRISPLD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Disorders for CRISPLD2 Gene

Relevant External Links for CRISPLD2

Genetic Association Database (GAD)
CRISPLD2
Human Genome Epidemiology (HuGE) Navigator
CRISPLD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRISPLD2

No disorders were found for CRISPLD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISPLD2 Gene

Publications for CRISPLD2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet B.T. … Hecht J.T. (Hum. Mol. Genet. 2007) 3 23
  3. LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts. (PMID: 25480331) Zhang H. … Kaplan F. (Am. J. Physiol. Lung Cell Mol. Physiol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. (PMID: 24090571) VA!sA!rhelyi V. … Patthy L. (Biochimie 2014) 3

Products for CRISPLD2 Gene

Sources for CRISPLD2 Gene

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