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Aliases for CRISPLD2 Gene

Aliases for CRISPLD2 Gene

  • Cysteine-Rich Secretory Protein LCCL Domain Containing 2 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 2 2 3
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 2 3 4
  • Cysteine-Rich Secretory Protein 11 3 4
  • CRISP-11 3 4
  • LCRISP2 3 4
  • CRISP11 3 4
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 2 3

External Ids for CRISPLD2 Gene

Previous HGNC Symbols for CRISPLD2 Gene

  • LCRISP2

Previous GeneCards Identifiers for CRISPLD2 Gene

  • GC16P083412
  • GC16P070606

Summaries for CRISPLD2 Gene

GeneCards Summary for CRISPLD2 Gene

CRISPLD2 (Cysteine-Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include heparin binding. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CRISPLD2 Gene

  • Promotes matrix assembly.

Gene Wiki entry for CRISPLD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD2 Gene

Genomics for CRISPLD2 Gene

Regulatory Elements for CRISPLD2 Gene

Genomic Location for CRISPLD2 Gene

Start:
84,819,981 bp from pter
End:
84,920,768 bp from pter
Size:
100,788 bases
Orientation:
Plus strand

Genomic View for CRISPLD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRISPLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD2 Gene

Proteins for CRISPLD2 Gene

  • Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0B8-CRLD2_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Protein Accession:
    Q9H0B8
    Secondary Accessions:
    • D3DUM0
    • Q6P590
    • Q6UWH0
    • Q6UXC6
    • Q96IB1
    • Q96K61

    Protein attributes for CRISPLD2 Gene

    Size:
    497 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Binds to heparin, dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for CRISPLD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD2 Gene

Proteomics data for CRISPLD2 Gene at MOPED

Post-translational modifications for CRISPLD2 Gene

  • Glycosylation at Asn27
  • Modification sites at PhosphoSitePlus

Other Protein References for CRISPLD2 Gene

No data available for DME Specific Peptides for CRISPLD2 Gene

Domains for CRISPLD2 Gene

Protein Domains for CRISPLD2 Gene

Suggested Antigen Peptide Sequences for CRISPLD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0B8

UniProtKB/Swiss-Prot:

CRLD2_HUMAN :
  • Q9H0B8
Domain:
  • Contains 2 LCCL domains.
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD2: view

No data available for Gene Families for CRISPLD2 Gene

Function for CRISPLD2 Gene

Molecular function for CRISPLD2 Gene

UniProtKB/Swiss-Prot Function: Promotes matrix assembly.

Gene Ontology (GO) - Molecular Function for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005539 glycosaminoglycan binding --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CRISPLD2: view

Animal Model Products

CRISPR Products

miRNA for CRISPLD2 Gene

miRTarBase miRNAs that target CRISPLD2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRISPLD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRISPLD2 Gene

Localization for CRISPLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISPLD2 Gene COMPARTMENTS Subcellular localization image for CRISPLD2 gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0030133 transport vesicle IDA --
GO:0031012 extracellular matrix IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CRISPLD2: view

Pathways for CRISPLD2 Gene

SuperPathways for CRISPLD2 Gene

No Data Available

Interacting Proteins for CRISPLD2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262424%0d%0a9606.ENSP00000311505%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000370395%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000262424 for CRISPLD2 Gene via STRING

Gene Ontology (GO) - Biological Process for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0030324 lung development IEA --
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD2: view

No data available for Pathways by source for CRISPLD2 Gene

Transcripts for CRISPLD2 Gene

Unigene Clusters for CRISPLD2 Gene

Cysteine-rich secretory protein LCCL domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRISPLD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD2 Gene

No ASD Table

Relevant External Links for CRISPLD2 Gene

GeneLoc Exon Structure for
CRISPLD2
ECgene alternative splicing isoforms for
CRISPLD2

Expression for CRISPLD2 Gene

mRNA expression in normal human tissues for CRISPLD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRISPLD2 Gene

SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene Hs.513779

genes like me logo Genes that share expressions with CRISPLD2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRISPLD2 Gene

Orthologs for CRISPLD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD2 35
  • 99.26 (n)
  • 99.8 (a)
CRISPLD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRISPLD2 35
  • 84.41 (n)
  • 83.87 (a)
CRISPLD2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRISPLD2 35
  • 86.46 (n)
  • 89.17 (a)
CRISPLD2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crispld2 35
  • 79.08 (n)
  • 77.94 (a)
Crispld2 16
Crispld2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRISPLD2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crispld2 35
  • 79.48 (n)
  • 79.68 (a)
chicken
(Gallus gallus)
Aves CRISPLD2 35
  • 72.7 (n)
  • 73.64 (a)
CRISPLD2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRISPLD2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld2 35
  • 67.95 (n)
  • 70.3 (a)
zebrafish
(Danio rerio)
Actinopterygii CRISPLD2 36
  • 60 (a)
OneToOne
LOC100535149 35
  • 66.25 (n)
  • 64.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 17 (a)
ManyToMany
scl-23 36
  • 19 (a)
ManyToMany
vap-1 36
  • 18 (a)
ManyToMany
Species with no ortholog for CRISPLD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD2 Gene

ENSEMBL:
Gene Tree for CRISPLD2 (if available)
TreeFam:
Gene Tree for CRISPLD2 (if available)

Paralogs for CRISPLD2 Gene

Selected SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CRISPLD2: view

Variants for CRISPLD2 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2485 -- 84,909,443(+) CTAAA(A/T)TGTTC utr-variant-3-prime
rs3042 -- 84,848,409(+) TGCTG(C/G)TGACA intron-variant
rs8939 -- 84,909,293(-) ACTGC(A/G)GGCTG utr-variant-3-prime
rs16938 -- 84,823,702(+) CCAGC(C/T)CGAGG intron-variant
rs17111 -- 84,823,638(+) GCTGT(A/G)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD2 Gene

Variant ID Type Subtype PubMed ID
nsv907081 CNV Gain 21882294
nsv457606 CNV Gain 19166990
dgv2935n71 CNV Gain 21882294
nsv457608 CNV Loss 19166990
nsv907085 CNV Gain 21882294
nsv907086 CNV Gain 21882294
nsv457610 CNV Loss 19166990

Relevant External Links for CRISPLD2 Gene

HapMap Linkage Disequilibrium report
CRISPLD2
Human Gene Mutation Database (HGMD)
CRISPLD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Disorders for CRISPLD2 Gene

(2) University of Copenhagen DISEASES for CRISPLD2 Gene

Relevant External Links for CRISPLD2

Genetic Association Database (GAD)
CRISPLD2
Human Genome Epidemiology (HuGE) Navigator
CRISPLD2
genes like me logo Genes that share disorders with CRISPLD2: view

No data available for UniProtKB/Swiss-Prot for CRISPLD2 Gene

Publications for CRISPLD2 Gene

  1. CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet B.T. … Hecht J.T. (Hum. Mol. Genet. 2007) 3 23 48
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CRISPLD2 Gene

Sources for CRISPLD2 Gene

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