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Aliases for CRISPLD2 Gene

Aliases for CRISPLD2 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 2 2 3 5
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 2 3 4
  • Cysteine-Rich Secretory Protein 11 3 4
  • Late Gestation Lung 1 2 3
  • CRISP-11 3 4
  • LCRISP2 3 4
  • CRISP11 3 4
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 2 2
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 2 3
  • Testis Secretory Sperm-Binding Protein Li 207a 3
  • Trypsin Inhibitor 3
  • LGL1 3

External Ids for CRISPLD2 Gene

Previous HGNC Symbols for CRISPLD2 Gene


Previous GeneCards Identifiers for CRISPLD2 Gene

  • GC16P083412
  • GC16P070606

Summaries for CRISPLD2 Gene

GeneCards Summary for CRISPLD2 Gene

CRISPLD2 (Cysteine Rich Secretory Protein LCCL Domain Containing 2) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is CRISPLD1.

UniProtKB/Swiss-Prot for CRISPLD2 Gene

  • Promotes matrix assembly.

Gene Wiki entry for CRISPLD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD2 Gene

Genomics for CRISPLD2 Gene

Regulatory Elements for CRISPLD2 Gene

Enhancers for CRISPLD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F085518 1.8 FANTOM5 Ensembl ENCODE 31.2 +703.5 703490 9.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF548 SP3 NFYC ENSG00000270184 KLHL36 CRISPLD2 RNU1-103P ZDHHC7 RN7SL381P ENSG00000269898 ENSG00000261177 ENSG00000269826 ENSG00000260859
GH16F084825 1.6 FANTOM5 Ensembl ENCODE 18.2 +13.3 13255 15.3 PKNOX1 CBX3 SIN3A RAD21 ZNF121 ZNF23 ZNF302 SCRT2 ZMIZ1 RCOR1 CRISPLD2 ZDHHC7 ENSG00000260859 LOC105371374 LOC123862
GH16F084879 1.1 ENCODE 26.3 +60.1 60073 1.2 PKNOX1 ATF1 CREB3L1 YY1 ELK1 GATA2 FOS KLF13 JUNB ZHX2 CRISPLD2 ZDHHC7 ENSG00000260859 ENSG00000261243 KIAA0513 KLHL36 LOC123862
GH16F084881 1.2 Ensembl ENCODE 18.1 +62.5 62497 2.6 PKNOX1 ATF1 TBL1XR1 GATA2 FOS CREM NCOA1 CEBPB ZEB2 NR2F2 CRISPLD2 KIAA0513 LOC123862 ENSG00000260859
GH16F084884 1.1 Ensembl ENCODE 18.6 +65.0 65014 1.6 HDAC1 GATA2 FOS CREM EGR2 ZBTB2 ZEB2 ZNF217 TFDP1 MTA1 CRISPLD2 LOC123862 ENSG00000260859
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Promoters for CRISPLD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001803531 -81 1001 TBP ZNF48 RAD21 RARA GLIS2 SCRT2 ZNF391 EGR2 SP5 NFYC
ENSR00000149726 1519 1801 KLF1 MNT NR2F2 RAD51 SCRT2 KLF9 CUX1 FOS

Genomic Location for CRISPLD2 Gene

84,819,981 bp from pter
84,920,768 bp from pter
100,788 bases
Plus strand

Genomic View for CRISPLD2 Gene

Genes around CRISPLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD2 Gene

Proteins for CRISPLD2 Gene

  • Protein details for CRISPLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Protein Accession:
    Secondary Accessions:
    • D3DUM0
    • Q6P590
    • Q6UWH0
    • Q6UXC6
    • Q96IB1
    • Q96K61

    Protein attributes for CRISPLD2 Gene

    497 amino acids
    Molecular mass:
    55920 Da
    Quaternary structure:
    • Binds to heparin, dermatan sulfate and chondroitin sulfate.

    Alternative splice isoforms for CRISPLD2 Gene


neXtProt entry for CRISPLD2 Gene

Post-translational modifications for CRISPLD2 Gene

  • Glycosylation at Asn 27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRISPLD2 Gene

Domains & Families for CRISPLD2 Gene

Protein Domains for CRISPLD2 Gene

Suggested Antigen Peptide Sequences for CRISPLD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LCCL domains.
  • Belongs to the CRISP family.
  • Contains 2 LCCL domains.
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD2: view

No data available for Gene Families for CRISPLD2 Gene

Function for CRISPLD2 Gene

Molecular function for CRISPLD2 Gene

UniProtKB/Swiss-Prot Function:
Promotes matrix assembly.

Gene Ontology (GO) - Molecular Function for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CRISPLD2: view
genes like me logo Genes that share phenotypes with CRISPLD2: view

Animal Models for CRISPLD2 Gene

MGI Knock Outs for CRISPLD2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISPLD2

miRNA for CRISPLD2 Gene

miRTarBase miRNAs that target CRISPLD2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRISPLD2 Gene

Localization for CRISPLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISPLD2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0030133 transport vesicle IDA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CRISPLD2: view

Pathways & Interactions for CRISPLD2 Gene

SuperPathways for CRISPLD2 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with CRISPLD2: view

Pathways by source for CRISPLD2 Gene

2 Reactome pathways for CRISPLD2 Gene

Interacting Proteins for CRISPLD2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000262424 Q9H0B8-CRLD2_HUMAN for CRISPLD2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CRISPLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
GO:0030324 lung development IEA --
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD2: view

No data available for SIGNOR curated interactions for CRISPLD2 Gene

Transcripts for CRISPLD2 Gene

Unigene Clusters for CRISPLD2 Gene

Cysteine-rich secretory protein LCCL domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD2 Gene

No ASD Table

Relevant External Links for CRISPLD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRISPLD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRISPLD2 Gene

Protein differential expression in normal tissues from HIPED for CRISPLD2 Gene

This gene is overexpressed in Lavage (57.7) and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRISPLD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRISPLD2 Gene:


SOURCE GeneReport for Unigene cluster for CRISPLD2 Gene:

genes like me logo Genes that share expression patterns with CRISPLD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CRISPLD2 Gene

Orthologs for CRISPLD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRISPLD2 34 35
  • 99.26 (n)
(Canis familiaris)
Mammalia CRISPLD2 34 35
  • 86.46 (n)
(Bos Taurus)
Mammalia CRISPLD2 34 35
  • 84.41 (n)
(Monodelphis domestica)
Mammalia CRISPLD2 35
  • 80 (a)
(Rattus norvegicus)
Mammalia Crispld2 34
  • 79.48 (n)
(Mus musculus)
Mammalia Crispld2 34 16 35
  • 79.08 (n)
(Ornithorhynchus anatinus)
Mammalia CRISPLD2 35
  • 76 (a)
(Gallus gallus)
Aves CRISPLD2 34 35
  • 72.7 (n)
(Anolis carolinensis)
Reptilia CRISPLD2 35
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld2 34
  • 67.95 (n)
(Danio rerio)
Actinopterygii LOC100535149 34
  • 66.25 (n)
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8483 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea scl-23 35
  • 19 (a)
vap-1 35
  • 18 (a)
scl-22 35
  • 17 (a)
Species where no ortholog for CRISPLD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD2 Gene

Gene Tree for CRISPLD2 (if available)
Gene Tree for CRISPLD2 (if available)

Paralogs for CRISPLD2 Gene

(4) SIMAP similar genes for CRISPLD2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CRISPLD2: view

Variants for CRISPLD2 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1004695 -- 84,883,802(+) GCATG(G/T)GCTGT intron-variant
rs1008154 -- 84,883,169(-) GCTTT(C/T)TTCCT intron-variant
rs1021478 -- 84,823,946(+) CAAGT(A/G)AGCTG intron-variant
rs1032451 -- 84,848,152(+) CAGCC(A/G)TGCCA intron-variant
rs10536185 -- 84,849,781(+) TGATC(-/TTAG)TTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD2 Gene

Variant ID Type Subtype PubMed ID
esv3639448 CNV gain 21293372
nsv1056758 CNV gain 25217958
nsv1066260 CNV gain 25217958
nsv1113825 CNV deletion 24896259
nsv1131282 CNV deletion 24896259
nsv457606 CNV gain 19166990
nsv457608 CNV loss 19166990
nsv457610 CNV loss 19166990
nsv483044 CNV gain 15286789
nsv573466 CNV gain 21841781
nsv573470 CNV loss 21841781
nsv573471 CNV loss 21841781
nsv573472 CNV loss 21841781
esv3639447 CNV gain 21293372
esv3639446 CNV gain 21293372
esv3639445 CNV gain 21293372
esv3639442 CNV gain 21293372
dgv5269n54 CNV loss 21841781

Variation tolerance for CRISPLD2 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.58; 94.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISPLD2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD2 Gene

Disorders for CRISPLD2 Gene

Relevant External Links for CRISPLD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRISPLD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISPLD2 Gene

Publications for CRISPLD2 Gene

  1. CRISPLD2: a novel NSCLP candidate gene. (PMID: 17616516) Chiquet B.T. … Hecht J.T. (Hum. Mol. Genet. 2007) 3 22 46 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. (PMID: 27597766) Zhang H. … Kaplan F. (Physiol Rep 2016) 2 3 64
  4. Testing reported associations of genetic risk factors for oral clefts in a large Irish study population. (PMID: 19937600) Carter T.C. … Mills J.L. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for CRISPLD2 Gene

Sources for CRISPLD2 Gene

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