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Aliases for CRISPLD1 Gene

Aliases for CRISPLD1 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 1 2 3 5
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 1 3 4
  • Cysteine-Rich Secretory Protein 10 3 4
  • Trypsin Inhibitor Hl 3 4
  • CocoaCrisp 3 4
  • CRISP-10 3 4
  • LCRISP1 3 4
  • CRISP10 3 4
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 1 2
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 1 3

External Ids for CRISPLD1 Gene

Previous HGNC Symbols for CRISPLD1 Gene

  • LCRISP1

Previous GeneCards Identifiers for CRISPLD1 Gene

  • GC08P076060
  • GC08P075896
  • GC08P071385

Summaries for CRISPLD1 Gene

GeneCards Summary for CRISPLD1 Gene

CRISPLD1 (Cysteine Rich Secretory Protein LCCL Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CRISPLD2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD1 Gene

Genomics for CRISPLD1 Gene

Regulatory Elements for CRISPLD1 Gene

Enhancers for CRISPLD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G074983 0.8 ENCODE 13.5 +0.3 340 1.7 CTCF RBBP5 RAD21 ZFHX2 GLIS2 POLR2A PATZ1 ZNF600 PRDM10 EGR2 CRISPLD1 ENSG00000254238 GC08P075024
GH08G074999 0.8 Ensembl ENCODE 9.8 +15.8 15778 1.4 TEAD4 POU5F1 CEBPB RBBP5 CHD7 PRDM1 ENSG00000254238 CRISPLD1 GC08P075024
GH08G075004 0.4 ENCODE 0.4 +19.7 19743 0.2 POU5F1 TCF7L2 ENSG00000254238 CRISPLD1 GC08P075024
GH08G075001 0.2 ENCODE 0.4 +16.8 16768 0.1 ENSG00000254238 CRISPLD1 GC08P075024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRISPLD1 on UCSC Golden Path with GeneCards custom track

Promoters for CRISPLD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226000 428 1800 CTCF RBBP5 RAD21 ZFHX2 GLIS2 POLR2A ZNF600 PRDM10 EGR2 MAZ

Genomic Location for CRISPLD1 Gene

Chromosome:
8
Start:
74,984,473 bp from pter
End:
75,034,558 bp from pter
Size:
50,086 bases
Orientation:
Plus strand

Genomic View for CRISPLD1 Gene

Genes around CRISPLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD1 Gene

Proteins for CRISPLD1 Gene

  • Protein details for CRISPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H336-CRLD1_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 1
    Protein Accession:
    Q9H336
    Secondary Accessions:
    • B2RA60
    • B7Z929

    Protein attributes for CRISPLD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    56888 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRISPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD1 Gene

Post-translational modifications for CRISPLD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRISPLD1 Gene

No data available for DME Specific Peptides for CRISPLD1 Gene

Domains & Families for CRISPLD1 Gene

Protein Domains for CRISPLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H336

UniProtKB/Swiss-Prot:

CRLD1_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD1: view

No data available for Gene Families for CRISPLD1 Gene

Function for CRISPLD1 Gene

Gene Ontology (GO) - Molecular Function for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CRISPLD1: view

Phenotypes for CRISPLD1 Gene

GenomeRNAi human phenotypes for CRISPLD1:
genes like me logo Genes that share phenotypes with CRISPLD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISPLD1

CRISPR Products

miRNA for CRISPLD1 Gene

miRTarBase miRNAs that target CRISPLD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISPLD1 Gene

Localization for CRISPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRISPLD1 gene
Compartment Confidence
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CRISPLD1: view

Pathways & Interactions for CRISPLD1 Gene

SuperPathways for CRISPLD1 Gene

No Data Available

Interacting Proteins for CRISPLD1 Gene

Gene Ontology (GO) - Biological Process for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD1: view

No data available for Pathways by source and SIGNOR curated interactions for CRISPLD1 Gene

Transcripts for CRISPLD1 Gene

Unigene Clusters for CRISPLD1 Gene

Cysteine-rich secretory protein LCCL domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -

Relevant External Links for CRISPLD1 Gene

GeneLoc Exon Structure for
CRISPLD1
ECgene alternative splicing isoforms for
CRISPLD1

Expression for CRISPLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRISPLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISPLD1 Gene

This gene is overexpressed in Artery - Aorta (x14.5), Artery - Tibial (x4.6), and Artery - Coronary (x4.4).

Protein differential expression in normal tissues from HIPED for CRISPLD1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRISPLD1 Gene



Protein tissue co-expression partners for CRISPLD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRISPLD1 Gene:

CRISPLD1

SOURCE GeneReport for Unigene cluster for CRISPLD1 Gene:

Hs.436542

Evidence on tissue expression from TISSUES for CRISPLD1 Gene

  • Heart(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with CRISPLD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRISPLD1 Gene

Orthologs for CRISPLD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD1 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia CRISPLD1 34 35
  • 93.6 (n)
cow
(Bos Taurus)
Mammalia CRISPLD1 34 35
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Crispld1 34 16 35
  • 88.4 (n)
rat
(Rattus norvegicus)
Mammalia Crispld1 34
  • 88.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CRISPLD1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRISPLD1 34 35
  • 82.22 (n)
lizard
(Anolis carolinensis)
Reptilia CRISPLD1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld1 34
  • 74.07 (n)
zebrafish
(Danio rerio)
Actinopterygii crispld1a 34 35
  • 69.27 (n)
crispld1b 35
  • 69 (a)
OneToMany
zgc63636 34
fruit fly
(Drosophila melanogaster)
Insecta CG8483 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-23 35
  • 19 (a)
ManyToMany
vap-1 35
  • 18 (a)
ManyToMany
scl-22 35
  • 16 (a)
ManyToMany
Species where no ortholog for CRISPLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD1 Gene

ENSEMBL:
Gene Tree for CRISPLD1 (if available)
TreeFam:
Gene Tree for CRISPLD1 (if available)

Paralogs for CRISPLD1 Gene

(3) SIMAP similar genes for CRISPLD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRISPLD1: view

Variants for CRISPLD1 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000016778 -- 74,992,032(+) TTTAT(A/C)TTTAT intron-variant
rs1000075450 -- 74,999,300(+) ACAGT(C/G)TATTT intron-variant, upstream-variant-2KB
rs1000168881 -- 75,029,106(+) TAAAG(C/G)CTACT intron-variant
rs1000170029 -- 75,008,739(+) AATGG(A/G)TTAAA intron-variant
rs1000281821 -- 75,018,436(+) CAGGT(C/G)CGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD1 Gene

Variant ID Type Subtype PubMed ID
esv2492216 CNV deletion 19546169
esv2737182 CNV deletion 23290073
esv2761437 CNV gain 21179565
esv28358 CNV gain+loss 19812545
esv3543676 CNV deletion 23714750
esv3576590 CNV gain 25503493
esv3617672 CNV gain 21293372
nsv1115107 CNV deletion 24896259
nsv1124354 CNV deletion 24896259

Variation tolerance for CRISPLD1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISPLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRISPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Disorders for CRISPLD1 Gene

Relevant External Links for CRISPLD1

Genetic Association Database (GAD)
CRISPLD1
Human Genome Epidemiology (HuGE) Navigator
CRISPLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRISPLD1

No disorders were found for CRISPLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISPLD1 Gene

Publications for CRISPLD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  4. Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. (PMID: 21254358) Chiquet B.T. … Hecht J.T. (Birth Defects Res. Part A Clin. Mol. Teratol. 2011) 3 64
  5. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 46 64

Products for CRISPLD1 Gene

Sources for CRISPLD1 Gene

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