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Aliases for CRISPLD1 Gene

Aliases for CRISPLD1 Gene

  • Cysteine Rich Secretory Protein LCCL Domain Containing 1 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 1 2 3
  • Cysteine-Rich Secretory Protein LCCL Domain Containing 1 3 5
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 1 3 4
  • Cysteine-Rich Secretory Protein 10 3 4
  • Trypsin Inhibitor Hl 3 4
  • CocoaCrisp 3 4
  • CRISP-10 3 4
  • LCRISP1 3 4
  • CRISP10 3 4

External Ids for CRISPLD1 Gene

Previous HGNC Symbols for CRISPLD1 Gene

  • LCRISP1

Previous GeneCards Identifiers for CRISPLD1 Gene

  • GC08P076060
  • GC08P075896
  • GC08P071385

Summaries for CRISPLD1 Gene

GeneCards Summary for CRISPLD1 Gene

CRISPLD1 (Cysteine Rich Secretory Protein LCCL Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CLEC18B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD1 Gene

Genomics for CRISPLD1 Gene

Regulatory Elements for CRISPLD1 Gene

Promoters for CRISPLD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRISPLD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRISPLD1 Gene

Chromosome:
8
Start:
74,984,473 bp from pter
End:
75,034,558 bp from pter
Size:
50,086 bases
Orientation:
Plus strand

Genomic View for CRISPLD1 Gene

Genes around CRISPLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISPLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD1 Gene

Proteins for CRISPLD1 Gene

  • Protein details for CRISPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H336-CRLD1_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 1
    Protein Accession:
    Q9H336
    Secondary Accessions:
    • B2RA60
    • B7Z929

    Protein attributes for CRISPLD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    56888 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRISPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD1 Gene

Proteomics data for CRISPLD1 Gene at MOPED

Post-translational modifications for CRISPLD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRISPLD1 Gene

No data available for DME Specific Peptides for CRISPLD1 Gene

Domains & Families for CRISPLD1 Gene

Protein Domains for CRISPLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H336

UniProtKB/Swiss-Prot:

CRLD1_HUMAN :
  • Contains 2 LCCL domains.
  • Belongs to the CRISP family.
Domain:
  • Contains 2 LCCL domains.
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD1: view

No data available for Gene Families for CRISPLD1 Gene

Function for CRISPLD1 Gene

Phenotypes for CRISPLD1 Gene

GenomeRNAi human phenotypes for CRISPLD1:
genes like me logo Genes that share phenotypes with CRISPLD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISPLD1

CRISPR Products

miRNA for CRISPLD1 Gene

miRTarBase miRNAs that target CRISPLD1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISPLD1 Gene

Localization for CRISPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISPLD1 Gene COMPARTMENTS Subcellular localization image for CRISPLD1 gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CRISPLD1 Gene

Pathways & Interactions for CRISPLD1 Gene

SuperPathways for CRISPLD1 Gene

No Data Available

Interacting Proteins for CRISPLD1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262207%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000221566%0d%0a9606.ENSP00000370395%0d%0a
Selected Interacting proteins: ENSP00000262207 for CRISPLD1 Gene via STRING

Gene Ontology (GO) - Biological Process for CRISPLD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRISPLD1 Gene

Drugs & Compounds for CRISPLD1 Gene

No Compound Related Data Available

Transcripts for CRISPLD1 Gene

Unigene Clusters for CRISPLD1 Gene

Cysteine-rich secretory protein LCCL domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -

Relevant External Links for CRISPLD1 Gene

GeneLoc Exon Structure for
CRISPLD1
ECgene alternative splicing isoforms for
CRISPLD1

Expression for CRISPLD1 Gene

mRNA expression in normal human tissues for CRISPLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISPLD1 Gene

This gene is overexpressed in Artery - Aorta (x14.5), Artery - Tibial (x4.6), and Artery - Coronary (x4.4).

Protein differential expression in normal tissues from HIPED for CRISPLD1 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRISPLD1 Gene



SOURCE GeneReport for Unigene cluster for CRISPLD1 Gene Hs.436542

genes like me logo Genes that share expression patterns with CRISPLD1: view

Protein tissue co-expression partners for CRISPLD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRISPLD1 Gene

Orthologs for CRISPLD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD1 36
  • 100 (a)
OneToOne
CRISPLD1 35
  • 99.73 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia CRISPLD1 36
  • 95 (a)
OneToOne
CRISPLD1 35
  • 92.13 (n)
  • 95.4 (a)
dog
(Canis familiaris)
Mammalia CRISPLD1 35
  • 93.6 (n)
  • 97 (a)
CRISPLD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crispld1 16
Crispld1 35
  • 88.4 (n)
  • 94.6 (a)
Crispld1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRISPLD1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crispld1 35
  • 88.27 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves CRISPLD1 35
  • 82.22 (n)
  • 86.26 (a)
CRISPLD1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRISPLD1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld1 35
  • 74.07 (n)
  • 77.6 (a)
zebrafish
(Danio rerio)
Actinopterygii crispld1a 36
  • 68 (a)
OneToMany
crispld1b 36
  • 69 (a)
OneToMany
crispld1a 35
  • 69.27 (n)
  • 71.66 (a)
zgc63636 35
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 16 (a)
ManyToMany
scl-23 36
  • 19 (a)
ManyToMany
vap-1 36
  • 18 (a)
ManyToMany
Species with no ortholog for CRISPLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD1 Gene

ENSEMBL:
Gene Tree for CRISPLD1 (if available)
TreeFam:
Gene Tree for CRISPLD1 (if available)

Paralogs for CRISPLD1 Gene

(3) SIMAP similar genes for CRISPLD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRISPLD1: view

Variants for CRISPLD1 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1945 - 75,016,693(+) TAAGC(G/T)CACAG reference, missense
rs960856 -- 74,982,672(-) TTTGT(A/T)GTTGA upstream-variant-2KB
rs1455794 -- 75,013,528(-) ACATG(A/C)AAAAG intron-variant
rs1455795 -- 75,011,865(-) AGTAT(C/T)TGCTT intron-variant
rs1378619 -- 75,023,791(+) GAGTG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD1 Gene

Variant ID Type Subtype PubMed ID
esv28358 CNV Gain+Loss 19812545
nsv891018 CNV Loss 21882294
nsv891019 CNV Loss 21882294
nsv891022 CNV Loss 21882294
esv2492216 CNV Deletion 19546169
esv2737182 CNV Deletion 23290073

Variation tolerance for CRISPLD1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISPLD1 Gene

HapMap Linkage Disequilibrium report
CRISPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Disorders for CRISPLD1 Gene

Relevant External Links for CRISPLD1

Genetic Association Database (GAD)
CRISPLD1
Human Genome Epidemiology (HuGE) Navigator
CRISPLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRISPLD1

No disorders were found for CRISPLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISPLD1 Gene

Publications for CRISPLD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. (PMID: 21254358) Chiquet B.T. … Hecht J.T. (Birth Defects Res. Part A Clin. Mol. Teratol. 2011) 3
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3
  5. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PMID: 18824526) Gibbs G.M. … O'Bryan M.K. (Endocr. Rev. 2008) 23

Products for CRISPLD1 Gene

Sources for CRISPLD1 Gene

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