CRISPLD1 Gene
protein-coding GIFtS : 45
GCID: GC08 P075896
cysteine-rich secretory protein LCCL domain containing 1 (Previous name: LCCL domain containing cysteine-rich secretory protein... ) (Previous symbol: LCRISP1 )
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Aliasesfor CRISPLD1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cysteine-Rich Secretory Protein LCCL Domain Containing 1 1 2 CRISP102 3 LCRISP11 2 3 CocoaCrisp2 3 LCCL Domain Containing Cysteine-Rich Secretory Protein 11 2 LCCL Domain-Containing Cysteine-Rich Secretory Protein 12 3 Cysteine-Rich Secretory Protein 102 3 Cocoacrisp1 Trypsin Inhibitor Hl2 3 DKFZp762F1331 CRISP-102 3 Cysteine-Rich Secretory Protein LCCL Domain-Containing 12
Export aliases for CRISPLD1 gene to outside databases Previous GC identifers: GC08P076060 GC08P071385
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Summariesfor CRISPLD1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CRISPLD1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008183.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CRISPLD1 gene promoter: RFX1 Elk-1 FOXF2 STAT5A Tal-1beta FOXL1 N-Myc MEF-2A aMEF-2 ITF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for CRISPLD1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CRISPLD1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.13 CRISPLD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08P075896: view genomic region
(about GC identifiers )
Start:
75,896,708 bp from pter
End:
75,946,793 bp from pter
Size:
50,086 bases
Orientation:
plus strand
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Proteinsfor CRISPLD1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CRLD1_HUMAN, Q9H336 (See
protein sequence )Recommended Name: Cysteine-rich secretory protein LCCL domain-containing 1 precursor Size : 500 amino acids; 56888 Da
Subcellular location : Secreted (Potential)
Secondary accessions : B2RA60Explore the universe of human proteins at neXtProt for CRISPLD1: NX_Q9H336 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H336 CRISPLD1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_113649.1 ENSEMBL proteins: ENSP00000262207 ENSP00000430504 ENSP00000430105 ENSP00000429746 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
CRISPLD1 for ontologies About GeneDecksing CRISPLD1 Antibody Products: Assay Products for CRISPLD1:
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Protein
Domains / Familiesfor CRISPLD1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CRISPLD1 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H336 ProtoNet protein and cluster: Q9H336
1 Blocks protein family : IPB001283 Allergen V5/Tpx-1 related UniProtKB/Swiss-Prot: CRLD1_HUMAN, Q9H336 Similarity : Belongs to the CRISP familySimilarity : Contains 2 LCCL domains
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Functionfor CRISPLD1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CRISPLD1 (NM_031461 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRISPLD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CRISPLD1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD1
Animal Models: Mouse knock-out Crispld1 tm1Lex for CRISPLD1 1 MGI phenotypic allele for Crispld1 (no phenotypes)
CRISPLD1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor CRISPLD1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRISPLD1
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Drugs & Compoundsfor CRISPLD1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CRISPLD1 Search CenterWatch for drugs/clinical trials and news about CRISPLD1 / CRLD1
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Transcriptsfor CRISPLD1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CRISPLD1 gene: NM_031461.5 Unigene Cluster for CRISPLD1:
Cysteine-rich secretory protein LCCL domain containing 1 Hs.436542 [show with all ESTs ] Unigene Representative Sequence: NM_031461 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000262207 (uc003yan.3 uc011lfk.2 uc011lfl.2 ) ENST00000519798 ENST00000520277 ENST00000523524 ENST00000517786 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CRISPLD1 (NM_031461 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRISPLD1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CRISPLD1
Additional cDNA sequence: AF142573.1 AF329197.1 AK304034.1 AK304350.1 AK314048.1 AL834301.1 AY358564.1 BC020514.1
6 DOTS entries : DT.444156 DT.97837464
DT.40293165 DT.100739341 DT.120630914 DT.100713134 24/77 AceView cDNA sequences (see all 77 ):
AI698316 AF142573 BU687051 BM906901 AA433951 AA476657 AI338457 AL044670 BC020514 AI222020 AI968449 AA406099 BP357192 NM_031461 AI083598 BQ013589 AY358564 AW182460 AL834301 CB161320 N67422 Z44826 CA413219 AI973251 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD1 About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 SP1 :                                       SP2 :                                       SP3 :           -                            
ECgene alternative splicing isoforms for CRISPLD1
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Expression for CRISPLD1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CRISPLD1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image CRISPLD1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CRISPLD1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CRISPLD1 SOURCE GeneReport for Unigene cluster: Hs.436542 SABiosciences Custom PCR Arrays for CRISPLD1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CRISPLD1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CRISPLD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CRISPLD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CRISPLD1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD1
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Orthologsfor CRISPLD1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CRISPLD1 gene from 4/12 species (see all 12 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Crispld11 , 5
cysteine-rich secretory protein LCCL domain containing more 1, 5
88.4(n) 1 94.6(a) 1
 
1 (5.32 cM) 5 83691 1 NM_031402.2 1 NP_113579.2 1 17727045 5
chicken (Gallus gallus)
Aves
CRISPLD11
cysteine-rich secretory protein LCCL domain containing more
82.86(n) 87.14(a)
 
395369 NM_204654.1 NP_989985.1
lizard (Anolis carolinensis)
Reptilia
CRISPLD16
--
85(a)
1 ↔ 1
4(34168462-34205840)
zebrafish (Danio rerio)
Actinopterygii
zgc636362
hypothetical protein MGC63636
76.05(n)
 
393442 BC055176.1
ENSEMBL Gene Tree for CRISPLD1 (if available)TreeFam Gene Tree for CRISPLD1 (if available)
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Paralogsfor CRISPLD1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CRISPLD1 gene CLEC18B 2 CRISPLD2 2 CLEC18C 2 PI16 2 GLIPR1 2 CRISP2 2 PI15 2 CRISP1 2 CRISP3 2 GLIPR1L1 2 CLEC18A 2 GLIPR1L2 2 R3HDML 2 3 SIMAP similar genes for CRISPLD1 using alignment to 4 protein entries: CRLD1_HUMAN (see all proteins ):CRISPLD2 PI15 R3HDML
CRISPLD1 for paralogs About GeneDecksing
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Genomic Variantsfor CRISPLD1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 8 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CRISPLD1 (75896708 - 75946793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CRISPLD1 2 CNVs : 100396 70392
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CRISPLD1
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Disorders
/ Diseasesfor CRISPLD1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CRISPLD1 for disorders About GeneDecksing 2 diseases for CRISPLD1 : About MalaCards cleft lip/palate cleft lip Human Genome Epidemiology (HuGE) Navigator: CRISPLD1 (2 documents) Export disorders for CRISPLD1 gene to outside databases
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Publicationsfor CRISPLD1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CRISPLD1 gene integrated from 9 sources : (articles sorted by number of sources associating them with CRISPLD1) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. (PubMed id 21254358) 1 Chiquet B.T....Hecht J.T. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PubMed id 18824526) 9 Gibbs G.M....O'Bryan M.K. (2008)
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External Searches for CRISPLD1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CRISPLD1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CRISPLD1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CRISPLD1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CRISPLD1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CRISPLD1 gene: Search GeneIP for patents involving CRISPLD1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CRISPLD1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CRISPLD1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CRISPLD1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CRISPLD1 OriGene Protein Over-expression Lysate for CRISPLD1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CRISPLD1 OriGene 3'-UTR Clone for CRISPLD1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CRISPLD1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CRISPLD1 OriGene Custom Protein Services for CRISPLD1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRISPLD1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CRISPLD1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CRISPLD1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CRISPLD1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CRISPLD1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CRISPLD1
CRISPLD1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISPLD1
Search ThermoFisher Antibodies for CRISPLD1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CRISPLD1
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Aliases for CRISPLD1
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Disorders / Diseases for CRISPLD1
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Expression for CRISPLD1
Function for CRISPLD1
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