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Aliases for CRISPLD1 Gene

Aliases for CRISPLD1 Gene

  • Cysteine-Rich Secretory Protein LCCL Domain Containing 1 2 3
  • LCCL Domain Containing Cysteine-Rich Secretory Protein 1 2 3
  • LCCL Domain-Containing Cysteine-Rich Secretory Protein 1 3 4
  • Cysteine-Rich Secretory Protein 10 3 4
  • Trypsin Inhibitor Hl 3 4
  • CocoaCrisp 3 4
  • CRISP-10 3 4
  • LCRISP1 3 4
  • CRISP10 3 4
  • Cysteine-Rich Secretory Protein LCCL Domain-Containing 1 3

External Ids for CRISPLD1 Gene

Previous HGNC Symbols for CRISPLD1 Gene

  • LCRISP1

Previous GeneCards Identifiers for CRISPLD1 Gene

  • GC08P076060
  • GC08P075896
  • GC08P071385

Summaries for CRISPLD1 Gene

GeneCards Summary for CRISPLD1 Gene

CRISPLD1 (Cysteine-Rich Secretory Protein LCCL Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CLEC18B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISPLD1 Gene

Genomics for CRISPLD1 Gene

Regulatory Elements for CRISPLD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRISPLD1 Gene

Start:
74,984,473 bp from pter
End:
75,034,558 bp from pter
Size:
50,086 bases
Orientation:
Plus strand

Genomic View for CRISPLD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRISPLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISPLD1 Gene

Proteins for CRISPLD1 Gene

  • Protein details for CRISPLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H336-CRLD1_HUMAN
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 1
    Protein Accession:
    Q9H336
    Secondary Accessions:
    • B2RA60
    • B7Z929

    Protein attributes for CRISPLD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    56888 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRISPLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISPLD1 Gene

Proteomics data for CRISPLD1 Gene at MOPED

Post-translational modifications for CRISPLD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRISPLD1 Gene

No data available for DME Specific Peptides for CRISPLD1 Gene

Domains for CRISPLD1 Gene

Protein Domains for CRISPLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H336

UniProtKB/Swiss-Prot:

CRLD1_HUMAN :
  • Q9H336
Domain:
  • Contains 2 LCCL domains.
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISPLD1: view

No data available for Gene Families for CRISPLD1 Gene

Function for CRISPLD1 Gene

Gene Ontology (GO) - Molecular Function for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CRISPLD1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRISPLD1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRISPLD1 Gene

Localization for CRISPLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISPLD1 Gene COMPARTMENTS Subcellular localization image for CRISPLD1 gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CRISPLD1: view

Pathways for CRISPLD1 Gene

SuperPathways for CRISPLD1 Gene

No Data Available

Interacting Proteins for CRISPLD1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262207%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000370395%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000262207 for CRISPLD1 Gene via STRING

Gene Ontology (GO) - Biological Process for CRISPLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060325 face morphogenesis IMP 21254358
genes like me logo Genes that share ontologies with CRISPLD1: view

No data available for Pathways by source for CRISPLD1 Gene

Transcripts for CRISPLD1 Gene

Unigene Clusters for CRISPLD1 Gene

Cysteine-rich secretory protein LCCL domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRISPLD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISPLD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -

Relevant External Links for CRISPLD1 Gene

GeneLoc Exon Structure for
CRISPLD1
ECgene alternative splicing isoforms for
CRISPLD1

Expression for CRISPLD1 Gene

mRNA expression in normal human tissues for CRISPLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISPLD1 Gene

This gene is overexpressed in Artery - Aorta (14.5), Artery - Tibial (4.6), and Artery - Coronary (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRISPLD1 Gene

SOURCE GeneReport for Unigene cluster for CRISPLD1 Gene Hs.436542

genes like me logo Genes that share expressions with CRISPLD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRISPLD1 Gene

Orthologs for CRISPLD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISPLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISPLD1 35
  • 99.73 (n)
  • 99.6 (a)
CRISPLD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRISPLD1 35
  • 92.13 (n)
  • 95.4 (a)
CRISPLD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRISPLD1 35
  • 93.6 (n)
  • 97 (a)
CRISPLD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crispld1 35
  • 88.4 (n)
  • 94.6 (a)
Crispld1 16
Crispld1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRISPLD1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRISPLD1 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crispld1 35
  • 88.27 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves CRISPLD1 35
  • 82.22 (n)
  • 86.26 (a)
CRISPLD1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRISPLD1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crispld1 35
  • 74.07 (n)
  • 77.6 (a)
zebrafish
(Danio rerio)
Actinopterygii crispld1a 35
  • 69.27 (n)
  • 71.66 (a)
crispld1a 36
  • 68 (a)
OneToMany
crispld1b 36
  • 69 (a)
OneToMany
zgc63636 35
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 16 (a)
ManyToMany
scl-23 36
  • 19 (a)
ManyToMany
vap-1 36
  • 18 (a)
ManyToMany
Species with no ortholog for CRISPLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRISPLD1 Gene

ENSEMBL:
Gene Tree for CRISPLD1 (if available)
TreeFam:
Gene Tree for CRISPLD1 (if available)

Paralogs for CRISPLD1 Gene

Selected SIMAP similar genes for CRISPLD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRISPLD1: view

Variants for CRISPLD1 Gene

Sequence variations from dbSNP and Humsavar for CRISPLD1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1945 - 75,016,693(+) TAAGC(G/T)CACAG reference, missense
rs719617 -- 75,029,931(-) GGTTC(C/T)AGGGA intron-variant
rs960856 -- 74,982,672(-) TTTGT(A/T)GTTGA upstream-variant-2KB
rs1017673 -- 75,009,699(-) AGACA(C/T)AGGTT intron-variant
rs1378614 -- 74,994,657(-) GGAAG(C/G)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISPLD1 Gene

Variant ID Type Subtype PubMed ID
esv28358 CNV Gain+Loss 19812545
nsv891018 CNV Loss 21882294
nsv891019 CNV Loss 21882294
nsv891022 CNV Loss 21882294
esv2492216 CNV Deletion 19546169
esv2737182 CNV Deletion 23290073

Relevant External Links for CRISPLD1 Gene

HapMap Linkage Disequilibrium report
CRISPLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISPLD1 Gene

Disorders for CRISPLD1 Gene

Relevant External Links for CRISPLD1

Genetic Association Database (GAD)
CRISPLD1
Human Genome Epidemiology (HuGE) Navigator
CRISPLD1
genes like me logo Genes that share disorders with CRISPLD1: view

No data available for UniProtKB/Swiss-Prot for CRISPLD1 Gene

Publications for CRISPLD1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PMID: 18824526) Gibbs G.M. … O'Bryan M.K. (Endocr. Rev. 2008) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CRISPLD1 Gene

Sources for CRISPLD1 Gene

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