Aliases for CRISP3 Gene
Aliases for CRISP3 Gene
External Ids for CRISP3 Gene
- HGNC: 16904
- Entrez Gene: 10321
- Ensembl: ENSG00000096006
- UniProtKB: P54108
Previous GeneCards Identifiers for CRISP3 Gene
- GC06M049696
- GC06M049741
- GC06M049805
- GC06M049425
Summaries for CRISP3 Gene
GeneCards Summary for CRISP3 Gene
CRISP3 (Cysteine Rich Secretory Protein 3) is a Protein Coding gene. An important paralog of this gene is CLEC18B.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP3 Gene
Genomics for CRISP3 Gene
Regulatory Elements for CRISP3 Gene
Enhancers for CRISP3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CRISP3 on UCSC Golden Path with GeneCards custom track
Promoters for CRISP3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CRISP3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CRISP3 gene promoter:
Regulatory Element Products
Genomic Location for CRISP3 Gene
- Chromosome:
- 6
- Start:
- 49,727,376 bp from pter
- End:
- 49,744,455 bp from pter
- Size:
- 17,080 bases
- Orientation:
- Minus strand
Genomic View for CRISP3 Gene
Genes around CRISP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.3 by Ensembl
- 6p12.3 by Entrez Gene
- 6p12.3 by HGNC
CRISP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRISP3 Gene
Proteins for CRISP3 Gene
-
Protein details for CRISP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P54108-CRIS3_HUMAN
- Recommended name:
- Cysteine-rich secretory protein 3
- Protein Accession:
- P54108
- A8K9S1
- B2R8I8
- Q15512
- Q3MJ82
- Q53FA9
- Q5JW83
- Q9H108
Protein attributes for CRISP3 Gene
- Size:
- 245 amino acids
- Molecular mass:
- 27630 Da
- Quaternary structure:
-
- Interacts with A1BG.
- SequenceCaution:
-
- Sequence=AAH69580.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH69602.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA64527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for CRISP3 Gene
Post-translational modifications for CRISP3 Gene
Other Protein References for CRISP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRISP3 (CRISP-3)
-
Custom Antibody ServicesOriGene Antibodies for CRISP3
- Novus Biologicals Antibodies for CRISP3
-
Cloud-Clone Corp. Antibodies for CRISP3
- Invitrogen Antibodies for CRISP3
- antibodies-online Antibodies for CRISP3: See all 37
- Search GeneTex for Antibodies for CRISP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRISP3
Protein Products
- R&D Systems Proteins and Enzymes for CRISP3 (CRISP-3)
-
OriGene Purified Proteins for CRISP3
- Search Origene for MassSpec and Protein Over-expression Lysates for CRISP3
- Origene Custom Protein Services for CRISP3
-
Cloud-Clone Corp. Proteins for CRISP3
- antibodies-online Proteins for CRISP3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CRISP3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CRISP3
-
Cloud-Clone Corp Assay Kits for CRISP3
- antibodies-online Kits for CRISP3: See all 9
No data available for DME Specific Peptides for CRISP3 Gene
Domains & Families for CRISP3 Gene
Protein Domains for CRISP3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRISP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P54108- Domain:
-
- Contains 1 SCP domain.
- Contains 1 ShKT domain.
- Family:
-
- Belongs to the CRISP family.
No data available for Gene Families for CRISP3 Gene
Function for CRISP3 Gene
Phenotypes for CRISP3 Gene
- GenomeRNAi human phenotypes for CRISP3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CRISP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
- Search ViGene Biosciences for CRISP3
CRISPR Products
-
OriGene CRISPR knockouts for CRISP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRISP3
- GenScript: Design CRISPR guide RNA sequences for CRISP3
miRNA for CRISP3 Gene
- miRTarBase miRNAs that target CRISP3
miRNA Products
- Search ViGene Biosciences for CRISP3
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CRISP3
- Browse OriGene Inhibitory RNA Products For CRISP3
-
ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
Clone Products
- OriGene clones in human for CRISP3
- OriGene ORF clones in human,mouse for CRISP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRISP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CRISP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CRISP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISP3 Gene
Localization for CRISP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRISP3 Gene
- Secreted. Note=In neutrophils, localized in specific granules.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042581 | specific granule | IDA | 8601434 |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for CRISP3 Gene
More details on SuperPathways for CRISP3
No Data Available
Interacting Proteins for CRISP3 Gene
No data available for Pathways by source and SIGNOR curated interactions for CRISP3 Gene
Transcripts for CRISP3 Gene
mRNA/cDNA for CRISP3 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (64) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CRISP3 Gene
- Cysteine-rich secretory protein 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CRISP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRISP3
- GenScript: Design CRISPR guide RNA sequences for CRISP3
miRNA Products
- Search ViGene Biosciences for CRISP3
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CRISP3
- Browse OriGene Inhibitory RNA Products For CRISP3
-
ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
Clone Products
- OriGene clones in human for CRISP3
- OriGene ORF clones in human,mouse for CRISP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CRISP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for CRISP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CRISP3 Gene
This gene is overexpressed in Minor Salivary Gland (x37.2), Esophagus - Mucosa (x6.3), and Vagina (x4.7).
This gene is overexpressed in Cervix (29.0), Serum (7.8), and Saliva (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRISP3 Gene
SOURCE GeneReport for Unigene cluster for CRISP3 Gene Hs.404466
mRNA Expression by UniProt/SwissProt for CRISP3 Gene
P54108-CRIS3_HUMAN
Tissue specificity:
Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.
Primer Products
-
OriGene qPCR primer pairs for CRISP3
-
OriGene qPCR primer pairs and template standards for CRISP3
No data available for Protein tissue co-expression partners for CRISP3 Gene
Orthologs for CRISP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | LOC481834 35 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | CRISP3 35 |
|
||
| CRISP3 36 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | CRISP3 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Crisp1 36 |
|
OneToMany | |
| Crisp3 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 36 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| -- 36 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | CRISP3 36 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| CSA.10077 36 |
|
ManyToMany |
- Species with no ortholog for CRISP3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CRISP3 Gene
Paralogs for CRISP3 Gene
(5) SIMAP similar genes for CRISP3 Gene using alignment to 4 proteins:
Variants for CRISP3 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs495335 | - | 49,733,810(+) | GCTGG(A/G)GGCAC | reference, missense | |
| rs1864312 | - | 49,733,726(+) | CACTG(A/C/T)GTTGG | reference, missense | |
| rs6902472 | -- | 49,726,943(+) | AAGTG(A/G)GATTG | downstream-variant-500B | |
| rs1652136 | -- | 49,741,137(+) | ACAAA(A/C)AAAAA | intron-variant | |
| rs10456626 | -- | 49,743,419(+) | GTCTT(A/G)GTCAT | intron-variant |
Residual Variation Intolerance Score:
75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.15;
80.72% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CRISP3 Gene
Disorders for CRISP3 Gene
Relevant External Links for CRISP3
No disorders were found for CRISP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISP3 Gene
Publications for CRISP3 Gene
- The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Kraetzschmar J. … Schleuning W.-D. (Eur. J. Biochem. 1996) 2 3 4 23 67
- Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PMID: 12223513) Udby L. … Kjeldsen L. (J. Leukoc. Biol. 2002) 2 3 23
- Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 23
- A model of the complex between human beta-microseminoprotein and CRISP-3 based on NMR data. (PMID: 19026612) Ghasriani H. … Drakenberg T. (Biochem. Biophys. Res. Commun. 2009) 3 23
- Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PMID: 19282327) Horne A.W. … Critchley H.O. (Mol. Hum. Reprod. 2009) 3 23
Products for CRISP3 Gene
- R&D Systems Antibodies for CRISP3 (CRISP-3)
- R&D Systems Proteins and Enzymes for CRISP3 (CRISP-3)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CRISP3
- Custom Assay ServicesOriGene ELISA Kits for CRISP3
- OriGene Purified Proteins for CRISP3
- Search Origene for MassSpec and Protein Over-expression Lysates for CRISP3
- Origene Custom Protein Services for CRISP3
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for CRISP3
- Browse OriGene Inhibitory RNA Products For CRISP3
- OriGene qPCR primer pairs for CRISP3
- OriGene qPCR primer pairs and template standards for CRISP3
- OriGene CRISPR knockouts for CRISP3
- OriGene clones in human for CRISP3
- OriGene ORF clones in human,mouse for CRISP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CRISP3
- GenScript Custom Assay Services for CRISP3
- GenScript Custom overexpressing Cell Line Services for CRISP3
- GenScript: Design CRISPR guide RNA sequences for CRISP3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CRISP3
- Novus Biologicals Antibodies for CRISP3
- Novus Biologicals proteins and lysates for CRISP3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CRISP3
- Cloud-Clone Corp. Proteins for CRISP3
- Cloud-Clone Corp Assay Kits for CRISP3
- antibodies-online Antibodies for CRISP3: See all 37
- antibodies-online Kits for CRISP3: See all 9
- antibodies-online Proteins for CRISP3: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CRISP3
- Search GeneTex for Proteins for CRISP3
- ViGene Biosciences adenoviral particle packaged cDNA for CRISP3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CRISP3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CRISP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CRISP3 gene
- Search ViGene Biosciences for CRISP3
- Search ViGene Biosciences for CRISP3
- Santa Cruz Biotechnology (SCBT) Antibodies for CRISP3
- Search Santa Cruz Biotechnology (SCBT) for CRISP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRISP3
Sources for CRISP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon