CRISP3 Gene

Aliases
for CRISP3 gene

Previous GC identifers: GC06M049696 GC06M049805 GC06M049425

Summaries
for CRISP3 gene

Genomic Views
for CRISP3 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007592.15  

SwitchGear Promoter luciferase reporter plasmid: CRISP3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRISP3

CRISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049741:  view genomic region     (about GC identifiers)

Proteins
for CRISP3 gene

Explore the universe of human proteins at neXtProt for CRISP3: NX_P54108

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CRISP3 (CRISP-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CRISP3 OriGene Custom Protein Services for CRISP3
	GenScript Custom Purified and Recombinant Proteins Services for CRISP3
	Novus Biologicals CRISP3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRISP3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CRISP3 (CRISP-3)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CRISP3
	GenScript Custom Superior Antibodies Services for CRISP3
	Novus Biologicals CRISP3 Antibody
	Search for Antibodies for CRISP3 at Abcam
	Uscn Antibodies for CRISP3
	Search ThermoFisher Antibodies for CRISP3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRISP3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRISP3

Protein Domains /
Families
for CRISP3 gene

ProtoNet protein and cluster: P54108

Function
for CRISP3 gene

miRNA Products:		OriGene 3'-UTR Clone: CRISP3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRISP3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CRISP3:
		hsa-miR-3149
		SwitchGear 3'UTR luciferase reporter plasmid: CRISP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRISP3 (see all 7) OriGene shRNA RFP: CRISP3 OriGene siRNA: CRISP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISP3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CRISP3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRISP3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRISP3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRISP3 (NM_006061)
		Sino Biological Human cDNA Clone for CRISP3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRISP3
		Search LifeMap BioReagents cell lines for CRISP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Crisp1)

Pathways & Interactions
for CRISP3 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CRISP3 gene

Transcripts
for CRISP3 gene

Expression
for CRISP3 gene

CRISP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGCCAAAT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeThoracic Perivascular Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRISP3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRISP3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRISP3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3

Orthologs
for CRISP3 gene

Paralogs
for CRISP3 gene

Paralogs for CRISP3 gene

CLEC18B²  CRISPLD2²  CLEC18C²  PI16²  GLIPR1²  CRISP2²  PI15²  CRISP1²  

CRISPLD1²  GLIPR1L1²  GLIPR1L2²  CLEC18A²  R3HDML²  

5 SIMAP similar genes for CRISP3 using alignment to 4 protein entries:     CRIS3_HUMAN (see all proteins):

CRISP2    CRISP1    GLIPR1    GLIPR1L1    PI16

CRISP3 for paralogs           About GeneDecksing

Genomic Variants
for CRISP3 gene

10/346 NCBI SNPs in CRISP3 are shown (see all 346)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1501308451,2		--	49694607(+)	TTAACA/GGGCTC	2	--	ds5001		0	--	--	--	--
rs753418821,2	F,	--	49694642(+)	GGGAGG/AGTGGA	2	--	ds5001		1		WA	118
rs69024721,2	C,F,H,	--	49694656(+)	AAGTGA/GGATTG	2	--	ds5001		17		NS EA NA WA	2338
rs1900213431,2		--	49694715(+)	AGATCA/GTGAAT	2	--	ds5001		0	--	--	--	--
rs1833315481,2		--	49694803(+)	AAGAGA/GTGCAG	2	--	ds5001		0	--	--	--	--
rs6193121,2	C,F,A,H,	--	49694901(+)	TACTGA/CAGTTT	2	--	ds5001		30		EA NA NS WA CSA	2544
rs1147922061,2	C,F,	--	49694909(+)	TTTGAT/CACTGG	2	--	ds5001		1		WA	118
rs1386565891,2		--	49694926(+)	ATATCA/GATCTG	2	--	ds5001		0	--	--	--	--
rs1493112071,2		--	49694959(+)	ATTATC/TTGAAA	2	--	ds5001		0	--	--	--	--
rs6967171,2	C,F,A,	--	49695102(+)	CAAGAC/TACTTT	2	--	ut31 ese3		8		NA WA EA	504

HapMap Linkage Disequilibrium report for CRISP3 (49695089 - 49712168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CRISP3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRISP3

DNA2.0 Custom Variant and Variant Library Synthesis for CRISP3

Disorders / Diseases
for CRISP3 gene

17 diseases for CRISP3

4 Novoseek disease relationships for CRISP3 gene    About this table

Publications
for CRISP3 gene

PubMed articles for CRISP3 gene, integrated from 9 sources (see all 54): (articles sorted by number of sources associating them with CRISP3)

Utopia: connect your pdf to the dynamic world of online information

1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)^{1, 2, 3, 9} Kraetzschmar J.... Schleuning W.-D. (1996)
2. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PubMed id 12223513)^{1, 3, 9} Udby L....Kjeldsen L. (2002)
3. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)^{1, 2, 9} Udby L.... Kjeldsen L. (2004)
4. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. (PubMed id 8601434)^{1, 2, 9} Kjeldsen L.... Borregaard N. (1996)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
7. Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. (PubMed id 16388501)^{1, 9} Bjartell A....Udby L. (2006)
8. Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. (PubMed id 17634540)^{1, 9} Bjartell A.S....Scardino P.T. (2007)
9. Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PubMed id 19282327)^{1, 9} Horne A.W....Critchley H.O. (2009)
10. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. (PubMed id 12647793)^{1, 9} Liao Q....Friess H. (2003)

External Searches for CRISP3 gene

Genome Databases showing CRISP3 gene

Other Databases showing CRISP3 gene

Specialized Databases showing CRISP3 gene

Products
for CRISP3 gene