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CRISP3 Gene

protein-coding   GIFtS: 53
GCID: GC06M049741

Cysteine-Rich Secretory Protein 3

  Search for CRISP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine-Rich Secretory Protein 31 2     CRS32
Specific Granule Protein Of 28 KDa2 3     Cysteine-Rich Secretory Protein-32
CRISP-32 3     dJ442L6.32
SGP282 3     Specific Granule Protein (28 KDa)2
Aeg22     

External Ids:    HGNC: 169041   Entrez Gene: 103212   Ensembl: ENSG000000960067   UniProtKB: P541083   

Export aliases for CRISP3 gene to outside databases

Previous GC identifers: GC06M049696 GC06M049805 GC06M049425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CRISP3 Gene:
CRISP3 (cysteine-rich secretory protein 3) is a protein-coding gene. An important paralog of this gene is CLEC18B.

Gene Wiki entry for CRISP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRISP3 gene promoter:
         HNF-3beta   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISP3 promoter sequence
   Search Chromatin IP Primers for CRISP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

CRISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISP3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049741:  view genomic region     (about GC identifiers)

Start:
49,695,089 bp from pter      End:
49,712,168 bp from pter
Size:
17,080 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein 3 precursor  
Size: 245 amino acids; 27630 Da
Subunit: Interacts with A1BG
Sequence caution: Sequence=AAH69580.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH69602.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36185.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA63984.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAA64527.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A8K9S1 B2R8I8 Q15512 Q3MJ82 Q53FA9 Q5JW83 Q9H108
Alternative splicing: 3 isoforms:  P54108-1   P54108-2   P54108-3   

Explore the universe of human proteins at neXtProt for CRISP3: NX_P54108

Explore proteomics data for CRISP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn239
  • Modification sites at PhosphoSitePlus

  • See CRISP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177915.1  NP_006052.2  

    ENSEMBL proteins: 
     ENSP00000263045   ENSP00000360201   ENSP00000346636   ENSP00000389026   ENSP00000377274  
     ENSP00000410469  

    CRISP3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CRISP3

     
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    Search eBioscience for ELISAs for CRISP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS
     IPR003582 ShKT_dom
     IPR013871 Cysteine_rich_secretory

    Graphical View of Domain Structure for InterPro Entry P54108

    ProtoNet protein and cluster: P54108

    2 Blocks protein domains:
    IPB001283 Allergen V5/Tpx-1 related
    IPB013871 Cysteine-rich secretory protein


    UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain
    Similarity: Contains 1 ShKT domain


    Find genes that share domains with CRISP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with CRISP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRISP3:
     Lamellipodia cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Crisp1):
     reproductive system 

    Find genes that share phenotypes with CRISP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crisp1tm1Pasc for CRISP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISP3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISP3

    miRNA
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    miRTarBase miRNAs that target CRISP3:
    hsa-mir-1229-3p (MIRT036271)

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    1 qRT-PCR Assays for microRNA that regulate CRISP3:
    hsa-miR-3149
    SwitchGear 3'UTR luciferase reporter plasmidCRISP3 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CRISP3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRIS3_HUMAN, P54108: Secreted. Note=In neutrophils, localized in specific granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA12009203
    GO:0005578proteinaceous extracellular matrix NAS12223513
    GO:0042581specific granule IDA12223513

    Find genes that share ontologies with CRISP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRISP3
    Interactions:

        GeneGlobe Interaction Network for CRISP3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CRISP3 (P541083 ENSP000002630454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A1BGP042173, ENSP000002631004I2D: score=1 STRING: ENSP00000263100
    BMPERENSP000002971614STRING: ENSP00000297161
    CRIM1ENSP000002805274STRING: ENSP00000280527
    --ENSP000003966644STRING: ENSP00000396664
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS12647793
    GO:0045087innate immune response NAS12223513

    Find genes that share ontologies with CRISP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRISP3 (CRIS3)

    1 Novoseek inferred chemical compound relationship for CRISP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    percoll 42 1 12223513 (1)



    Find genes that share compounds with CRISP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRISP3 gene (2 alternative transcripts): 
    NM_001190986.1  NM_006061.2  

    Unigene Cluster for CRISP3:

    Cysteine-rich secretory protein 3
    Hs.404466  [show with all ESTs]
    Unigene Representative Sequence: NM_001190986
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263045 ENST00000371159 ENST00000354620 ENST00000433368(uc021zai.1 uc003ozs.3)
    ENST00000393666 ENST00000423399
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CRISP3:
    hsa-miR-3149
    SwitchGear 3'UTR luciferase reporter plasmidCRISP3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CRISP3
      QuantiFast Probe-based Assays in human, mouse, rat CRISP3

    Additional mRNA sequence: 

    AK223380.1 AK292786.1 AK313387.1 BC069580.1 BC069602.1 BC101539.1 X94323.1 X95240.1 

    7 DOTS entries:

    DT.107746  DT.121376065  DT.121376073  DT.121376066  DT.121376071  DT.121308552  DT.85103119 

    Selected AceView cDNA sequences (see all 64):

    NM_006061 X94323 BC069602 X95240 BC069580 AW075694 BE673586 AI791346 
    AI474434 BF897404 BF897378 BP334614 BP334549 AA888534 CN479307 BM993763 
    AW468294 BV198855 AW236196 BF446166 BE855975 AI400952 CA487317 AL703262 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRISP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCCAAAT
    CRISP3 Expression
    About this image


    CRISP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Esophagus (Gastrointestinal Tract)
    CRISP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRISP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404466

    UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108
    Tissue specificity: Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CRISP3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crisp15 cysteine-rich secretory protein 1   --   17 (19.47 cM) 40293758 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    56(a)
    1 → many
    3(108320648-108333075)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    54(a)
    51(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(121628264-121655431)
    1(121596101-121610603)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377213852   -- 79.16(n)    137721385 
    zebrafish
    (Danio rerio)
    Actinopterygii CRISP36
    cysteine-rich secretory protein 3
    42(a)
    1 → many
    16(52339308-52358047) ENSDARG00000091103


    ENSEMBL Gene Tree for CRISP3 (if available)
    TreeFam Gene Tree for CRISP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRISP3 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISP12  
    CRISPLD12  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for CRISP3 using alignment to 4 protein entries:     CRIS3_HUMAN (see all proteins):
    CRISP2    CRISP1    GLIPR1    GLIPR1L1    PI16

    Find genes that share paralogs with CRISP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRISP3 (see all 431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501308451,2
    --49694607(+) TTAACA/GGGCTC 2 -- ds50010--------
    rs753418821,2
    F--49694642(+) GGGAGG/AGTGGA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs69024721,2
    C,F,H--49694656(+) AAGTGA/GGATTG 2 -- ds500117Minor allele frequency- G:0.20NS EA NA WA 2338
    rs1900213431,2
    --49694715(+) AGATCA/GTGAAT 2 -- ds50010--------
    rs1833315481,2
    --49694803(+) AAGAGA/GTGCAG 2 -- ds50010--------
    rs6193121,2
    C,F,A,H--49694901(+) TACTGA/CAGTTT 2 -- ds500130Minor allele frequency- C:0.07EA NA NS WA CSA 2544
    rs1147922061,2
    C,F--49694909(+) TTTGAT/CACTGG 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1386565891,2
    --49694926(+) ATATCA/GATCTG 2 -- ds50010--------
    rs1493112071,2
    C--49694959(+) ATTATC/TTGAAA 2 -- ds50010--------
    rs6967171,2
    C,F,A--49695102(+) CAAGAC/TACTtt 2 -- ut31 ese38Minor allele frequency- T:0.22NA WA EA 504

    HapMap Linkage Disequilibrium report for CRISP3 (49695089 - 49712168 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRISP3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CRISP3           About GenesLikeMe

    4 Novoseek inferred disease relationships for CRISP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 18.6 11 12433721 (4), 17634540 (3), 16388501 (1)
    inflammation 0 1 17665393 (1)
    adenocarcinoma 0 1 12433721 (1)
    cancer 0 3 16388501 (1), 12647793 (1), 12433721 (1)

    Human Genome Epidemiology (HuGE) Navigator: CRISP3 (1 document)

    Export disorders for CRISP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRISP3 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with CRISP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)1, 2, 3, 9 Kraetzschmar J.... Schleuning W.-D. (Eur. J. Biochem. 1996)
    2. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PubMed id 12223513)1, 3, 9 Udby L....Kjeldsen L. (J. Leukoc. Biol. 2002)
    3. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)1, 2, 9 Udby L.... Kjeldsen L. (Biochemistry 2004)
    4. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. (PubMed id 8601434)1, 2, 9 Kjeldsen L.... Borregaard N. (FEBS Lett. 1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. (PubMed id 16388501)1, 9 Bjartell A....Udby L. (Prostate 2006)
    8. Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. (PubMed id 17634540)1, 9 Bjartell A.S....Scardino P.T. (Clin. Cancer Res. 2007)
    9. Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PubMed id 19282327)1, 9 Horne A.W....Critchley H.O. (Mol. Hum. Reprod. 2009)
    10. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. (PubMed id 12647793)1, 9 Liao Q....Friess H. (Histol. Histopathol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10321 HGNC: 16904 AceView: CRISP3 Ensembl:ENSG00000096006 euGenes: HUgn10321
    ECgene: CRISP3 H-InvDB: CRISP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRISP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRISP3 gene:
    Search GeneIP for patents involving CRISP3

    GeneCards and IP:
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