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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRISP3 Gene

protein-coding   GIFtS: 52
GCID: GC06M049741

Cysteine-Rich Secretory Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteine-Rich Secretory Protein 31 2     CRS32
Specific Granule Protein Of 28 KDa2 3     Cysteine-Rich Secretory Protein-32
CRISP-32 3     dJ442L6.32
SGP282 3     Specific Granule Protein (28 KDa)2
Aeg22     

External Ids:    HGNC: 169041   Entrez Gene: 103212   Ensembl: ENSG000000960067   UniProtKB: P541083   

Export aliases for CRISP3 gene to outside databases

Previous GC identifers: GC06M049696 GC06M049805 GC06M049425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CRISP3 Gene: 
CRISP3 (cysteine-rich secretory protein 3) is a protein-coding gene. Diseases associated with CRISP3 include vernal keratoconjunctivitis, and ectopic pregnancy. GO annotations related to this gene include molecular_function. An important paralog of this gene is CLEC18B.

Gene Wiki entry for CRISP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRISP3 gene promoter:
         HNF-3beta   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRISP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRISP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

CRISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISP3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049741:  view genomic region     (about GC identifiers)

Start:
49,695,089 bp from pter      End:
49,712,168 bp from pter
Size:
17,080 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein 3 precursor  
Size: 245 amino acids; 27630 Da
Subunit: Interacts with A1BG
Subcellular location: Secreted. Note=In neutrophils, localized in specific granules
Sequence caution: Sequence=AAH69580.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH69602.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36185.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA63984.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAA64527.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A8K9S1 B2R8I8 Q15512 Q3MJ82 Q53FA9 Q5JW83 Q9H108
Alternative splicing: 3 isoforms:  P54108-1   P54108-2   P54108-3   

Explore the universe of human proteins at neXtProt for CRISP3: NX_P54108

Explore proteomics data for CRISP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54108

  • CRISP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRISP3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177915.1  NP_006052.2  

    ENSEMBL proteins: 
     ENSP00000263045   ENSP00000360201   ENSP00000346636   ENSP00000389026   ENSP00000377274  
     ENSP00000410469  

    Human Recombinant Protein Products for CRISP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CRISP3 (CRISP-3)
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    OriGene Protein Over-expression Lysate for CRISP3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CRISP3
    GenScript Custom Purified and Recombinant Proteins Services for CRISP3
    Novus Biologicals CRISP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRISP3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA12009203
    GO:0005578proteinaceous extracellular matrix NAS12223513
    GO:0042581specific granule IDA12223513

    CRISP3 for ontologies           About GeneDecksing



    CRISP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRISP3 (CRISP-3)
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    Novus Biologicals CRISP3 Antibody
    Abcam antibodies for CRISP3
    Cloud-Clone Corp. Antibodies for CRISP3 
    Search ThermoFisher Antibodies for CRISP3
    LSBio Antibodies in human, mouse, rat for CRISP3 

    Assay Products for CRISP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRISP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRISP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRISP3 
    Cloud-Clone Corp. CLIAs for CRISP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS
     IPR013871 Cysteine_rich_secretory

    Graphical View of Domain Structure for InterPro Entry P54108

    ProtoNet protein and cluster: P54108

    2 Blocks protein domains:
    IPB001283 Allergen V5/Tpx-1 related
    IPB013871 Cysteine-rich secretory protein


    UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain
    Similarity: Contains 1 ShKT domain


    CRISP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    CRISP3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRISP3:
     Lamellipodia cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Crisp1):
     reproductive system 

    CRISP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crisp1tm1Pasc for CRISP3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRISP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRISP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRISP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRISP3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRISP3:
    hsa-miR-3149
    SwitchGear 3'UTR luciferase reporter plasmidCRISP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRISP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRISP3
    Sirion Biotech Customized adenovirus for overexpression of CRISP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CRISP3 (see all 11)
    OriGene ORF clones in mouse, rat for CRISP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRISP3 (NM_006061)
    Sino Biological Human cDNA Clone for CRISP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP3
    Sirion Biotech Customized lentivirus for stable overexpression of CRISP3 
                         Customized lentivirus expression plasmids for stable overexpression of CRISP3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRISP3
    Search LifeMap BioReagents cell lines for CRISP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRISP3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CRISP3 (P541083 ENSP000002630454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A1BGP042173, ENSP000002631004I2D: score=1 STRING: ENSP00000263100
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS12647793
    GO:0045087innate immune response NAS12223513

    CRISP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRISP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRISP3 (CRIS3)

    1 Novoseek inferred chemical compound relationship for CRISP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    percoll 42 1 12223513 (1)

    Search CenterWatch for drugs/clinical trials and news about CRISP3 / CRIS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRISP3 gene (2 alternative transcripts): 
    NM_001190986.1  NM_006061.2  

    Unigene Cluster for CRISP3:

    Cysteine-rich secretory protein 3
    Hs.404466  [show with all ESTs]
    Unigene Representative Sequence: NM_001190986
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263045 ENST00000371159 ENST00000354620 ENST00000433368(uc021zai.1 uc003ozs.3)
    ENST00000393666 ENST00000423399
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRISP3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRISP3:
    hsa-miR-3149
    SwitchGear 3'UTR luciferase reporter plasmidCRISP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRISP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISP3
    Clone
    Products:
         
    OriGene clones in human, mouse for CRISP3 (see all 11)
    OriGene ORF clones in mouse, rat for CRISP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRISP3 (NM_006061)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP3
    Sirion Biotech Customized lentivirus for stable overexpression of CRISP3 
                         Customized lentivirus expression plasmids for stable overexpression of CRISP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRISP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CRISP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRISP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRISP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISP3

    Additional mRNA sequence: 

    AK223380.1 AK292786.1 AK313387.1 BC069580.1 BC069602.1 BC101539.1 X94323.1 X95240.1 

    7 DOTS entries:

    DT.107746  DT.121376065  DT.121376073  DT.121376066  DT.121376071  DT.121308552  DT.85103119 

    24/64 AceView cDNA sequences (see all 64):

    BC069602 X94323 X95240 BC069580 NM_006061 AL703262 BM993763 AW236196 
    CN479307 BF446166 CA487317 AW075694 BE855975 BP359356 BF897378 AI474434 
    BV198855 BP334549 AW468294 BP334614 BP333729 AI791346 BF897404 AI400952 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRISP3 expression in normal human tissues (normalized intensities)      CRISP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCCAAAT
    CRISP3 Expression
    About this image


    CRISP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             trachea   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Pancreas (Endocrine System)
             Pancreatic Islet   
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Oral Cavity (Gastrointestinal Tract)
             Salivary gland   

    See CRISP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRISP3

    SOURCE GeneReport for Unigene cluster: Hs.404466

    UniProtKB/Swiss-Prot: CRIS3_HUMAN, P54108
    Tissue specificity: Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon

        SABiosciences Custom PCR Arrays for CRISP3
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRISP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRISP3 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crisp11 , 5 cysteine-rich secretory protein 11, 5 65.71(n)1
    55.33(a)1
      17 (19.47 cM)5
    115711  NM_009638.31  NP_033768.31 
     402937585 
    chicken
    (Gallus gallus)
    Aves CRISP16
    Uncharacterized protein
    56(a)
    1 → many
    3(108320648-108333075)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    55(a)
    51(a)
    many ↔ many
    many ↔ many
    1(121628264-121655431)
    1(121596101-121610603)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377213852   -- 79.16(n)    137721385 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005365001 natrin-1-like 53.43(n)
    47.37(a)
      100536500  XM_003200271.1  XP_003200319.1 
    worm
    (Caenorhabditis elegans)
    Secernentea scl-146
    scl-26
    (see all 21)
    Protein SCL-2
    (see all 21)
    32(a)
    32(a)
    (see all 21)
    many ↔ many
    many ↔ many
    (see all 21)
    IV(13165516-13166755)
    IV(13057678-13059092)


    ENSEMBL Gene Tree for CRISP3 (if available)
    TreeFam Gene Tree for CRISP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRISP3 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISP12  
    CRISPLD12  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for CRISP3 using alignment to 4 protein entries:     CRIS3_HUMAN (see all proteins):
    CRISP2    CRISP1    GLIPR1    GLIPR1L1    PI16

    CRISP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/431 SNPs in CRISP3 are shown (see all 431)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501308451,2
    --49694607(+) TTAACA/GGGCTC 2 -- ds50010--------
    rs753418821,2
    F--49694642(+) GGGAGG/AGTGGA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs69024721,2
    C,F,H--49694656(+) AAGTGA/GGATTG 2 -- ds500117Minor allele frequency- G:0.20NS EA NA WA 2338
    rs1900213431,2
    --49694715(+) AGATCA/GTGAAT 2 -- ds50010--------
    rs1833315481,2
    --49694803(+) AAGAGA/GTGCAG 2 -- ds50010--------
    rs6193121,2
    C,F,A,H--49694901(+) TACTGA/CAGTTT 2 -- ds500130Minor allele frequency- C:0.07EA NA NS WA CSA 2544
    rs1147922061,2
    C,F--49694909(+) TTTGAT/CACTGG 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1386565891,2
    --49694926(+) ATATCA/GATCTG 2 -- ds50010--------
    rs1493112071,2
    C--49694959(+) ATTATC/TTGAAA 2 -- ds50010--------
    rs6967171,2
    C,F,A--49695102(+) CAAGAC/TACTtt 2 -- ut31 ese38Minor allele frequency- T:0.22NA WA EA 504

    HapMap Linkage Disequilibrium report for CRISP3 (49695089 - 49712168 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRISP3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    16 diseases for CRISP3:    About MalaCards
    vernal keratoconjunctivitis    ectopic pregnancy    otitis media    keratoconjunctivitis
    sjogren's syndrome    epididymitis    sinusitis    atopic dermatitis
    dermatitis    inflammatory bowel disease    prostate cancer    prostatitis
    hepatitis b    hepatitis    ovarian cancer    pancreatitis


    CRISP3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CRISP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 18.6 11 12433721 (4), 17634540 (3), 16388501 (1)
    inflammation 0 1 17665393 (1)
    adenocarcinoma 0 1 12433721 (1)
    cancer 0 3 16388501 (1), 12647793 (1), 12433721 (1)

    Human Genome Epidemiology (HuGE) Navigator: CRISP3 (1 document)

    Export disorders for CRISP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRISP3 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with CRISP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)1, 2, 3, 9 Kraetzschmar J.... Schleuning W.-D. (1996)
    2. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PubMed id 12223513)1, 3, 9 Udby L....Kjeldsen L. (2002)
    3. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)1, 2, 9 Udby L.... Kjeldsen L. (2004)
    4. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. (PubMed id 8601434)1, 2, 9 Kjeldsen L.... Borregaard N. (1996)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. (PubMed id 16388501)1, 9 Bjartell A....Udby L. (2006)
    8. Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. (PubMed id 17634540)1, 9 Bjartell A.S....Scardino P.T. (2007)
    9. Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PubMed id 19282327)1, 9 Horne A.W....Critchley H.O. (2009)
    10. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. (PubMed id 12647793)1, 9 Liao Q....Friess H. (2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10321 HGNC: 16904 AceView: CRISP3 Ensembl:ENSG00000096006 euGenes: HUgn10321
    ECgene: CRISP3 H-InvDB: CRISP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CRISP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CRISP3 gene:
    Search GeneIP for patents involving CRISP3

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