CRISP3 Gene

Aliases
for CRISP3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06M049696 GC06M049805 GC06M049425

Summaries
for CRISP3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CRISP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_007592.16  

SwitchGear Promoter luciferase reporter plasmid: CRISP3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISP3

CRISP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049741:  view genomic region     (about GC identifiers)

Proteins
for CRISP3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CRISP3: NX_P54108

Explore proteomics data for CRISP3 at MOPED

Post-translational modifications: 

CRISP3 Human Recombinant Protein Products:

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	antibodies-online proteins for CRISP3 (6 products)
	antibodies-online peptides for CRISP3

CRISP3 Antibody Products:

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	antibodies-online antibodies for CRISP3 (24 products)

CRISP3 Assay Products:

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	antibodies-online kits for CRISP3 (8 products)

Domains /
Families
for CRISP3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P54108

Find genes that share domains with CRISP3           About GenesLikeMe

Function
for CRISP3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Crisp1)

genOway: Develop your customized and physiologically relevant rodent model for CRISP3

miRNA Products:		miRTarBase miRNAs that target CRISP3: hsa-mir-1229-3p (MIRT036271)
		Block miRNA regulation of human, mouse, rat CRISP3 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate CRISP3:
		hsa-miR-3149
		SwitchGear 3'UTR luciferase reporter plasmid: CRISP3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CRISP3
		Predesigned siRNA for gene silencing in human, mouse, rat CRISP3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CRISP3

Clone Products:		OriGene clones in human, mouse for CRISP3 (see all 9) OriGene ORF clones in mouse, rat for CRISP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CRISP3 (NM_006061)
		Sino Biological Human cDNA Clone for CRISP3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRISP3
		Browse ESI BIO Cell Lines and PureStem Progenitors for CRISP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3

Localization
for CRISP3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
lysosome	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for CRISP3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for CRISP3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CRISP3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CRISP3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CRISP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGAGCCAAAT

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Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles
Testis (Reproductive System)
Sertoli cells Seminiferous Tubules
Bone (Muscoskeletal System)
Bone Marrow
Esophagus (Gastrointestinal Tract)

Primer Products:		OriGene qPCR primer pairs and template standards for CRISP3 OriGene qSTAR qPCR primer pairs in human, mouse for CRISP3
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISP3
		QuantiTect SYBR Green Assays in human, mouse, rat CRISP3
		QuantiFast Probe-based Assays in human, mouse, rat CRISP3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP3

Orthologs
for CRISP3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CRISP3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CRISP3 gene

CLEC18B²  CRISPLD2²  CLEC18C²  PI16²  GLIPR1²  CRISP2²  PI15²  CRISP1²  

CRISPLD1²  GLIPR1L1²  CLEC18A²  GLIPR1L2²  R3HDML²  

5 SIMAP similar genes for CRISP3 using alignment to 4 protein entries:     CRIS3_HUMAN (see all proteins):

CRISP2    CRISP1    GLIPR1    GLIPR1L1    PI16

Find genes that share paralogs with CRISP3           About GenesLikeMe

Genomic Variants
for CRISP3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CRISP3 (see all 431)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1501308451,2		--	49694607(+)	TTAACA/GGGCTC	2	--	ds5001		0	--	--	--	--
rs753418821,2	F	--	49694642(+)	GGGAGG/AGTGGA	2	--	ds5001		1		WA	118
rs69024721,2	C,F,H	--	49694656(+)	AAGTGA/GGATTG	2	--	ds5001		17		NS EA NA WA	2338
rs1900213431,2		--	49694715(+)	AGATCA/GTGAAT	2	--	ds5001		0	--	--	--	--
rs1833315481,2		--	49694803(+)	AAGAGA/GTGCAG	2	--	ds5001		0	--	--	--	--
rs6193121,2	C,F,A,H	--	49694901(+)	TACTGA/CAGTTT	2	--	ds5001		30		EA NA NS WA CSA	2544
rs1147922061,2	C,F	--	49694909(+)	TTTGAT/CACTGG	2	--	ds5001		1		WA	118
rs1386565891,2		--	49694926(+)	ATATCA/GATCTG	2	--	ds5001		0	--	--	--	--
rs1493112071,2	C	--	49694959(+)	ATTATC/TTGAAA	2	--	ds5001		0	--	--	--	--
rs6967171,2	C,F,A	--	49695102(+)	CAAGAC/TACTtt	2	--	ut31 ese3		8		NA WA EA	504

HapMap Linkage Disequilibrium report for CRISP3 (49695089 - 49712168 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CRISP3: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CRISP3

DNA2.0 Custom Variant and Variant Library Synthesis for CRISP3

Disorders / Diseases
for CRISP3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for CRISP3

4 Novoseek inferred disease relationships for CRISP3 gene    About this table

Publications
for CRISP3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CRISP3 gene, integrated from 10 sources (see all 56): (articles sorted by number of sources associating them with CRISP3)

Utopia: connect your pdf to the dynamic world of online information

1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)^{1, 2, 3, 9} Kraetzschmar J.... Schleuning W.-D. (Eur. J. Biochem. 1996)
2. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PubMed id 12223513)^{1, 3, 9} Udby L....Kjeldsen L. (J. Leukoc. Biol. 2002)
3. Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. (PubMed id 15461460)^{1, 2, 9} Udby L.... Kjeldsen L. (Biochemistry 2004)
4. SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. (PubMed id 8601434)^{1, 2, 9} Kjeldsen L.... Borregaard N. (FEBS Lett. 1996)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
7. Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. (PubMed id 16388501)^{1, 9} Bjartell A....Udby L. (Prostate 2006)
8. Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. (PubMed id 17634540)^{1, 9} Bjartell A.S....Scardino P.T. (Clin. Cancer Res. 2007)
9. Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PubMed id 19282327)^{1, 9} Horne A.W....Critchley H.O. (Mol. Hum. Reprod. 2009)
10. Preferential expression of cystein-rich secretory protein-3 (CRISP-3) in chronic pancreatitis. (PubMed id 12647793)^{1, 9} Liao Q....Friess H. (Histol. Histopathol. 2003)

External Searches for CRISP3 gene

Genome Databases showing CRISP3 gene

Other Databases showing CRISP3 gene

Specialized Databases showing CRISP3 gene

Products
for CRISP3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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