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Aliases for CRISP3 Gene

Aliases for CRISP3 Gene

  • Cysteine Rich Secretory Protein 3 2 3
  • Specific Granule Protein Of 28 KDa 3 4
  • CRISP-3 3 4
  • SGP28 3 4
  • Cysteine-Rich Secretory Protein-3 3
  • Specific Granule Protein (28 KDa) 3
  • Cysteine-Rich Secretory Protein 3 5
  • DJ442L6.3 3
  • Aeg2 3
  • CRS3 3

External Ids for CRISP3 Gene

Previous GeneCards Identifiers for CRISP3 Gene

  • GC06M049696
  • GC06M049741
  • GC06M049805
  • GC06M049425

Summaries for CRISP3 Gene

GeneCards Summary for CRISP3 Gene

CRISP3 (Cysteine Rich Secretory Protein 3) is a Protein Coding gene. An important paralog of this gene is CLEC18B.

Gene Wiki entry for CRISP3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP3 Gene

Genomics for CRISP3 Gene

Regulatory Elements for CRISP3 Gene

Promoters for CRISP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRISP3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CRISP3 gene promoter:

Genomic Location for CRISP3 Gene

Chromosome:
6
Start:
49,727,376 bp from pter
End:
49,744,455 bp from pter
Size:
17,080 bases
Orientation:
Minus strand

Genomic View for CRISP3 Gene

Genes around CRISP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP3 Gene

Proteins for CRISP3 Gene

  • Protein details for CRISP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54108-CRIS3_HUMAN
    Recommended name:
    Cysteine-rich secretory protein 3
    Protein Accession:
    P54108
    Secondary Accessions:
    • A8K9S1
    • B2R8I8
    • Q15512
    • Q3MJ82
    • Q53FA9
    • Q5JW83
    • Q9H108

    Protein attributes for CRISP3 Gene

    Size:
    245 amino acids
    Molecular mass:
    27630 Da
    Quaternary structure:
    • Interacts with A1BG.
    SequenceCaution:
    • Sequence=AAH69580.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH69602.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63984.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA64527.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CRISP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISP3 Gene

Proteomics data for CRISP3 Gene at MOPED

Post-translational modifications for CRISP3 Gene

  • Glycosylation at Asn 239
  • Modification sites at PhosphoSitePlus

Other Protein References for CRISP3 Gene

Antibody Products

No data available for DME Specific Peptides for CRISP3 Gene

Domains & Families for CRISP3 Gene

Suggested Antigen Peptide Sequences for CRISP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54108

UniProtKB/Swiss-Prot:

CRIS3_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
  • Contains 1 ShKT domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP3: view

No data available for Gene Families for CRISP3 Gene

Function for CRISP3 Gene

Phenotypes for CRISP3 Gene

genes like me logo Genes that share phenotypes with CRISP3: view

Animal Model Products

miRNA for CRISP3 Gene

miRTarBase miRNAs that target CRISP3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISP3 Gene

Localization for CRISP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP3 Gene

Secreted. Note=In neutrophils, localized in specific granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISP3 Gene COMPARTMENTS Subcellular localization image for CRISP3 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CRISP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042581 specific granule IDA 8601434
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRISP3: view

Pathways & Interactions for CRISP3 Gene

SuperPathways for CRISP3 Gene

No Data Available

Interacting Proteins for CRISP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000389026%0d%0a9606.ENSP00000263100%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000328835%0d%0a
Selected Interacting proteins: P54108-CRIS3_HUMAN ENSP00000389026 for CRISP3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CRISP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRISP3 Gene

Drugs & Compounds for CRISP3 Gene

(1) Additional Compounds for CRISP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRISP3: view

Transcripts for CRISP3 Gene

Unigene Clusters for CRISP3 Gene

Cysteine-rich secretory protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP3 Gene

No ASD Table

Relevant External Links for CRISP3 Gene

GeneLoc Exon Structure for
CRISP3
ECgene alternative splicing isoforms for
CRISP3

Expression for CRISP3 Gene

mRNA expression in normal human tissues for CRISP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP3 Gene

This gene is overexpressed in Minor Salivary Gland (x37.2), Esophagus - Mucosa (x6.3), and Vagina (x4.7).

Protein differential expression in normal tissues from HIPED for CRISP3 Gene

This gene is overexpressed in Cervix (29.0), Serum (7.8), and Saliva (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRISP3 Gene



SOURCE GeneReport for Unigene cluster for CRISP3 Gene Hs.404466

mRNA Expression by UniProt/SwissProt for CRISP3 Gene

P54108-CRIS3_HUMAN
Tissue specificity: Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.
genes like me logo Genes that share expression patterns with CRISP3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CRISP3 Gene

Orthologs for CRISP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRISP3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC481834 35
  • 77.43 (n)
  • 68.87 (a)
chimpanzee
(Pan troglodytes)
Mammalia CRISP3 35
  • 99.1 (n)
  • 98.45 (a)
CRISP3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRISP3 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Crisp1 36
  • 55 (a)
OneToMany
Crisp3 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 56 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CRISP3 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
CSA.10077 36
  • 16 (a)
ManyToMany
Species with no ortholog for CRISP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP3 Gene

ENSEMBL:
Gene Tree for CRISP3 (if available)
TreeFam:
Gene Tree for CRISP3 (if available)

Paralogs for CRISP3 Gene

(5) SIMAP similar genes for CRISP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CRISP3: view

Variants for CRISP3 Gene

Sequence variations from dbSNP and Humsavar for CRISP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs495335 - 49,733,810(+) GCTGG(A/G)GGCAC reference, missense
rs1864312 - 49,733,726(+) CACTG(A/C/T)GTTGG reference, missense
rs488132 -- 49,728,760(+) CAGGA(A/C/G/T)GCCTT reference, synonymous-codon
rs508949 -- 49,744,722(-) CAGAA(A/G)TAATT upstream-variant-2KB
rs509699 -- 49,736,833(-) TAATT(A/C)CTATC intron-variant

Variation tolerance for CRISP3 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISP3 Gene

HapMap Linkage Disequilibrium report
CRISP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRISP3 Gene

Disorders for CRISP3 Gene

Relevant External Links for CRISP3

Human Genome Epidemiology (HuGE) Navigator
CRISP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRISP3

No disorders were found for CRISP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRISP3 Gene

Publications for CRISP3 Gene

  1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Kraetzschmar J. … Schleuning W.-D. (Eur. J. Biochem. 1996) 2 3 4 23 67
  2. Identification of human cysteine-rich secretory protein 3 (CRISP-3) as a matrix protein in a subset of peroxidase-negative granules of neutrophils and in the granules of eosinophils. (PMID: 12223513) Udby L. … Kjeldsen L. (J. Leukoc. Biol. 2002) 2 3 23
  3. Human CRISP-3 binds serum alpha(1)B-glycoprotein across species. (PMID: 20116414) Udby L. … Borregaard N. (Biochim. Biophys. Acta 2010) 3 23
  4. A model of the complex between human beta-microseminoprotein and CRISP-3 based on NMR data. (PMID: 19026612) Ghasriani H. … Drakenberg T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  5. Endometrial cysteine-rich secretory protein 3 is inhibited by human chorionic gonadotrophin, and is increased in the decidua of tubal ectopic pregnancy. (PMID: 19282327) Horne A.W. … Critchley H.O. (Mol. Hum. Reprod. 2009) 3 23

Products for CRISP3 Gene

Sources for CRISP3 Gene

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