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Aliases for CRISP2 Gene

Aliases for CRISP2 Gene

  • Cysteine-Rich Secretory Protein 2 2 3
  • Cancer/Testis Antigen 36 2 3 4
  • TPX1 3 4 6
  • Testis Specific Protein 1 (Probe H4-1 P3-1) 2 3
  • Testis-Specific Protein TPX-1 3 4
  • CRISP-2 3 4
  • GAPDL5 3 4
  • TSP1 3 6
  • CT36 3 4
  • Glyceraldehyde-3-Phosphate Dehydrogenase-Like 5 3

External Ids for CRISP2 Gene

Previous HGNC Symbols for CRISP2 Gene

  • GAPDL5
  • TPX1

Previous GeneCards Identifiers for CRISP2 Gene

  • GC06M049661
  • GC06M049706
  • GC06M049768
  • GC06M049390

Summaries for CRISP2 Gene

GeneCards Summary for CRISP2 Gene

CRISP2 (Cysteine-Rich Secretory Protein 2) is a Protein Coding gene. Diseases associated with CRISP2 include epididymitis and orchitis. Among its related pathways are p53 Signaling. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CRISP2 Gene

  • May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Gene Wiki entry for CRISP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP2 Gene

Genomics for CRISP2 Gene

Regulatory Elements for CRISP2 Gene

Genomic Location for CRISP2 Gene

49,692,358 bp from pter
49,713,590 bp from pter
21,233 bases
Minus strand

Genomic View for CRISP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP2 Gene

Proteins for CRISP2 Gene

  • Protein details for CRISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K8M0
    • Q53FF2
    • Q5U8Z9
    • Q7Z7B2

    Protein attributes for CRISP2 Gene

    243 amino acids
    Molecular mass:
    27259 Da
    Quaternary structure:
    • Interacts with NSUN4 isoform 3.

    Three dimensional structures from OCA and Proteopedia for CRISP2 Gene

    Alternative splice isoforms for CRISP2 Gene


neXtProt entry for CRISP2 Gene

Proteomics data for CRISP2 Gene at MOPED

Post-translational modifications for CRISP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRISP2 Gene

Antibody Products

No data available for DME Specific Peptides for CRISP2 Gene

Domains for CRISP2 Gene

Suggested Antigen Peptide Sequences for CRISP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P16562
  • Contains 1 SCP domain.
  • Contains 1 ShKT domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP2: view

No data available for Gene Families for CRISP2 Gene

Function for CRISP2 Gene

Molecular function for CRISP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRISP2 Gene

Localization for CRISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP2 Gene


Subcellular locations from

Jensen Localization Image for CRISP2 Gene COMPARTMENTS Subcellular localization image for CRISP2 gene
Compartment Confidence
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for CRISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8665901
genes like me logo Genes that share ontologies with CRISP2: view

Pathways for CRISP2 Gene

SuperPathways for CRISP2 Gene

Superpath Contained pathways
1 p53 Signaling
genes like me logo Genes that share pathways with CRISP2: view

Pathways by source for CRISP2 Gene

1 Sino Biological pathway for CRISP2 Gene

Interacting Proteins for CRISP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000339155 for CRISP2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CRISP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with CRISP2: view

Compounds for CRISP2 Gene

(1) HMDB Compounds for CRISP2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for CRISP2 Gene

Compound -log(P) Hits PubMed IDs
helothermine 96.1 1
cysteine 34.4 3
genes like me logo Genes that share compounds with CRISP2: view

Transcripts for CRISP2 Gene

Unigene Clusters for CRISP2 Gene

Cysteine-rich secretory protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRISP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -

Relevant External Links for CRISP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRISP2 Gene

mRNA expression in normal human tissues for CRISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP2 Gene

This gene is overexpressed in Testis (49.1).

Protein differential expression in normal tissues for CRISP2 Gene

This gene is overexpressed in Ovary (49.0) and Testis (20.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRISP2 Gene

SOURCE GeneReport for Unigene cluster for CRISP2 Gene Hs.2042

mRNA Expression by UniProt/SwissProt for CRISP2 Gene

Tissue specificity: Testis and epididymis
genes like me logo Genes that share expressions with CRISP2: view

Expression partners for CRISP2 Gene

In Situ Assay Products

Orthologs for CRISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRISP2 35
  • 85.19 (n)
  • 81.48 (a)
  • 82 (a)
(Canis familiaris)
Mammalia CRISP2 35
  • 86.69 (n)
  • 81.07 (a)
  • 82 (a)
(Mus musculus)
Mammalia Crisp2 35
  • 78.06 (n)
  • 70.89 (a)
Crisp2 16
Crisp2 36
  • 70 (a)
(Pan troglodytes)
Mammalia CRISP2 35
  • 99.59 (n)
  • 99.18 (a)
  • 87 (a)
(Rattus norvegicus)
Mammalia Crisp2 35
  • 76.65 (n)
  • 68.35 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
(Gallus gallus)
Aves CRISP2 35
  • 61.23 (n)
  • 54.51 (a)
-- 36
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 51 (a)
(Danio rerio)
Actinopterygii LOC100536500 35
  • 51.24 (n)
  • 41.92 (a)
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009085 35
  • 47.72 (n)
  • 41.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
CSA.10077 36
  • 16 (a)
Species with no ortholog for CRISP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP2 Gene

Gene Tree for CRISP2 (if available)
Gene Tree for CRISP2 (if available)

Paralogs for CRISP2 Gene

Selected SIMAP similar genes for CRISP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRISP2: view

Variants for CRISP2 Gene

Sequence variations from dbSNP and Humsavar for CRISP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12624 -- 49,692,705(-) ACCAG(G/T)GGAAA utr-variant-3-prime, nc-transcript-variant
rs168624 -- 49,696,601(-) TTTTC(C/T)TTTTT intron-variant
rs187233 -- 49,691,990(-) GTAAC(A/G)ACAGG downstream-variant-500B
rs187360 -- 49,710,808(-) GTATT(C/G)AGAAT intron-variant, upstream-variant-2KB
rs189664 -- 49,707,831(-) CTCAC(A/G)TGCAG intron-variant

Relevant External Links for CRISP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRISP2 Gene

Disorders for CRISP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CRISP2 Gene in MalaCards »

(2) Diseases for CRISP2 Gene including...

(2) University of Copenhagen DISEASES for CRISP2 Gene

Relevant External Links for CRISP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRISP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CRISP2 Gene

Publications for CRISP2 Gene

  1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Kraetzschmar J. … Schleuning W.-D. (Eur. J. Biochem. 1996) 2 3 4 23
  2. Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. (PMID: 18550510) Jamsai D. … O'Bryan M.K. (Hum. Reprod. 2008) 3 23 48
  3. Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. (PMID: 2613236) Kasahara M. … Goodfellow P.N. (Genomics 1989) 2 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CRISP2 Gene

Sources for CRISP2 Gene

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