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Aliases for CRISP2 Gene

Aliases for CRISP2 Gene

  • Cysteine Rich Secretory Protein 2 2 3
  • Cancer/Testis Antigen 36 2 3 4
  • Testis Specific Protein 1 (Probe H4-1 P3-1) 2 3
  • Testis-Specific Protein TPX-1 3 4
  • CRISP-2 3 4
  • GAPDL5 3 4
  • TPX1 3 4
  • CT36 3 4
  • Glyceraldehyde-3-Phosphate Dehydrogenase-Like 5 3
  • Cysteine-Rich Secretory Protein 2 5
  • Testicular Tissue Protein Li 43 3
  • TSP1 3

External Ids for CRISP2 Gene

Previous HGNC Symbols for CRISP2 Gene

  • GAPDL5
  • TPX1

Previous GeneCards Identifiers for CRISP2 Gene

  • GC06M049661
  • GC06M049706
  • GC06M049768
  • GC06M049390

Summaries for CRISP2 Gene

GeneCards Summary for CRISP2 Gene

CRISP2 (Cysteine Rich Secretory Protein 2) is a Protein Coding gene. Diseases associated with CRISP2 include cholecystolithiasis and orchitis. Among its related pathways are p53 Signaling. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CRISP2 Gene

  • May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Gene Wiki entry for CRISP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP2 Gene

Genomics for CRISP2 Gene

Regulatory Elements for CRISP2 Gene

Genomic Location for CRISP2 Gene

Chromosome:
6
Start:
49,676,659 bp from pter
End:
49,714,198 bp from pter
Size:
37,540 bases
Orientation:
Minus strand

Genomic View for CRISP2 Gene

Genes around CRISP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRISP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRISP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP2 Gene

Proteins for CRISP2 Gene

  • Protein details for CRISP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16562-CRIS2_HUMAN
    Recommended name:
    Cysteine-rich secretory protein 2
    Protein Accession:
    P16562
    Secondary Accessions:
    • A8K8M0
    • Q53FF2
    • Q5U8Z9
    • Q7Z7B2

    Protein attributes for CRISP2 Gene

    Size:
    243 amino acids
    Molecular mass:
    27259 Da
    Quaternary structure:
    • Interacts with NSUN4 isoform 3.

    Three dimensional structures from OCA and Proteopedia for CRISP2 Gene

    Alternative splice isoforms for CRISP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRISP2 Gene

Proteomics data for CRISP2 Gene at MOPED

Post-translational modifications for CRISP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRISP2 Gene

Antibody Products

No data available for DME Specific Peptides for CRISP2 Gene

Domains & Families for CRISP2 Gene

Suggested Antigen Peptide Sequences for CRISP2 Gene

Graphical View of Domain Structure for InterPro Entry

P16562

UniProtKB/Swiss-Prot:

CRIS2_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
  • Contains 1 ShKT domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP2: view

No data available for Gene Families for CRISP2 Gene

Function for CRISP2 Gene

Molecular function for CRISP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate some ion channels activity and therebye regulate calcium fluxes during sperm capacitation.

Phenotypes for CRISP2 Gene

genes like me logo Genes that share phenotypes with CRISP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRISP2

miRNA for CRISP2 Gene

miRTarBase miRNAs that target CRISP2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRISP2 Gene

Localization for CRISP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRISP2 Gene COMPARTMENTS Subcellular localization image for CRISP2 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for CRISP2 Gene

Pathways & Interactions for CRISP2 Gene

SuperPathways for CRISP2 Gene

Superpath Contained pathways
1 p53 Signaling
genes like me logo Genes that share pathways with CRISP2: view

Pathways by source for CRISP2 Gene

1 Sino Biological pathway for CRISP2 Gene

Interacting Proteins for CRISP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000339155%0d%0a9606.ENSP00000280527%0d%0a
Selected Interacting proteins: ENSP00000339155 for CRISP2 Gene via STRING

Symbol External ID(s) Details
CRIM1

Gene Ontology (GO) - Biological Process for CRISP2 Gene

None

No data available for SIGNOR curated interactions for CRISP2 Gene

Drugs & Compounds for CRISP2 Gene

(2) Drugs for CRISP2 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CRISP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRISP2: view

Transcripts for CRISP2 Gene

Unigene Clusters for CRISP2 Gene

Cysteine-rich secretory protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9: - - - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - -

Relevant External Links for CRISP2 Gene

GeneLoc Exon Structure for
CRISP2
ECgene alternative splicing isoforms for
CRISP2

Expression for CRISP2 Gene

mRNA expression in normal human tissues for CRISP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP2 Gene

This gene is overexpressed in Testis (x49.1).

Protein differential expression in normal tissues from HIPED for CRISP2 Gene

This gene is overexpressed in Ovary (49.0) and Testis (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRISP2 Gene



SOURCE GeneReport for Unigene cluster for CRISP2 Gene Hs.2042

mRNA Expression by UniProt/SwissProt for CRISP2 Gene

P16562-CRIS2_HUMAN
Tissue specificity: Testis and epididymis.
genes like me logo Genes that share expression patterns with CRISP2: view

Protein tissue co-expression partners for CRISP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CRISP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRISP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRISP2 36
  • 87 (a)
OneToOne
CRISP2 35
  • 99.59 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia CRISP2 35
  • 85.19 (n)
  • 81.48 (a)
CRISP2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRISP2 36
  • 82 (a)
OneToOne
CRISP2 35
  • 86.69 (n)
  • 81.07 (a)
mouse
(Mus musculus)
Mammalia Crisp2 16
Crisp2 36
  • 70 (a)
OneToOne
Crisp2 35
  • 78.06 (n)
  • 70.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Crisp2 35
  • 76.65 (n)
  • 68.35 (a)
chicken
(Gallus gallus)
Aves CRISP2 35
  • 61.23 (n)
  • 54.51 (a)
-- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CRISP3 36
  • 40 (a)
OneToMany
LOC100536500 35
  • 51.24 (n)
  • 41.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009085 35
  • 47.72 (n)
  • 41.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.10077 36
  • 16 (a)
ManyToMany
Species with no ortholog for CRISP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP2 Gene

ENSEMBL:
Gene Tree for CRISP2 (if available)
TreeFam:
Gene Tree for CRISP2 (if available)

Paralogs for CRISP2 Gene

(5) SIMAP similar genes for CRISP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRISP2: view

Variants for CRISP2 Gene

Sequence variations from dbSNP and Humsavar for CRISP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34457011 - 49,698,387(+) CTGCA(C/T)TGGGA nc-transcript-variant, reference, missense
rs12624 -- 49,692,705(-) ACCAG(G/T)GGAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs189664 -- 49,707,831(-) CTCAC(A/G)TGCAG intron-variant
rs360543 -- 49,713,665(-) GGAGG(C/G)GGGGG intron-variant, upstream-variant-2KB
rs360547 -- 49,712,794(+) CAACG(C/T)CCTGA intron-variant

Variation tolerance for CRISP2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRISP2 Gene

HapMap Linkage Disequilibrium report
CRISP2
Human Gene Mutation Database (HGMD)
CRISP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRISP2 Gene

Disorders for CRISP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRISP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cholecystolithiasis
orchitis
  • inflammation of testis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CRISP2

Genetic Association Database (GAD)
CRISP2
Human Genome Epidemiology (HuGE) Navigator
CRISP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRISP2
genes like me logo Genes that share disorders with CRISP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRISP2 Gene

Publications for CRISP2 Gene

  1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Kraetzschmar J. … Schleuning W.-D. (Eur. J. Biochem. 1996) 2 3 4 23 67
  2. Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. (PMID: 18550510) Jamsai D. … O'Bryan M.K. (Hum. Reprod. 2008) 3 23
  3. Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. (PMID: 2613236) Kasahara M. … Goodfellow P.N. (Genomics 1989) 2 3
  4. The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia. (PMID: 25505194) Zhou J.H. … Liu C.D. (Biol. Reprod. 2015) 3
  5. Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment. (PMID: 23661501) Nimlamool W. … Lowe-Krentz L.J. (Mol. Reprod. Dev. 2013) 3

Products for CRISP2 Gene

Sources for CRISP2 Gene

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