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CRISP2 Gene

protein-coding   GIFtS: 55
GCID: GC06M049706

Cysteine-Rich Secretory Protein 2

(Previous name: testis specific protein 1 (probe H4-1 p3-1))
(Previous symbols: GAPDL5, TPX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine-Rich Secretory Protein 21 2     Testis-Specific Protein TPX-12 3
TPX11 2 3 5     CRISP-22 3
GAPDL51 2 3     CT362 3
Cancer/Testis Antigen 361 2 3     TSP12 5
Testis Specific Protein 1 (Probe H4-1 P3-1)1 2     Glyceraldehyde-3-Phosphate Dehydrogenase-Like 52

External Ids:    HGNC: 120241   Entrez Gene: 71802   Ensembl: ENSG000001244907   OMIM: 1874305   UniProtKB: P165623   

Export aliases for CRISP2 gene to outside databases

Previous GC identifers: GC06M049661 GC06M049768 GC06M049390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CRISP2 Gene:
CRISP2 (cysteine-rich secretory protein 2) is a protein-coding gene. Diseases associated with CRISP2 include orchitis, and epididymitis. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: CRIS2_HUMAN, P16562
Function: May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation
(By similarity)

Gene Wiki entry for CRISP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRISP2 gene promoter:
         Max1   USF1   RFX1   USF2   STAT5A   CREB   GATA-6   MRF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISP2 promoter sequence
   Search Chromatin IP Primers for CRISP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

CRISP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049706:  view genomic region     (about GC identifiers)

Start:
49,660,072 bp from pter      End:
49,681,299 bp from pter
Size:
21,228 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRIS2_HUMAN, P16562 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein 2 precursor  
Size: 243 amino acids; 27259 Da
Subunit: Interacts with NSUN4 isoform 3 (By similarity)
1 PDB 3D structure from and Proteopedia for CRISP2:
2CQ7 (3D)    
Secondary accessions: A8K8M0 Q53FF2 Q5U8Z9 Q7Z7B2
Alternative splicing: 2 isoforms:  P16562-1   P16562-2   

Explore the universe of human proteins at neXtProt for CRISP2: NX_P16562

Explore proteomics data for CRISP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRISP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001135879.1  NP_001135880.1  NP_001135889.1  NP_001135907.1  NP_001248751.1  NP_003287.1  

    ENSEMBL proteins: 
     ENSP00000339155  

    CRISP2 Human Recombinant Protein Products:

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    CRISP2 Assay Products:

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    Cloud-Clone Corp. CLIAs for CRISP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS
     IPR003582 ShKT_dom
     IPR013871 Cysteine_rich_secretory

    Graphical View of Domain Structure for InterPro Entry P16562

    ProtoNet protein and cluster: P16562

    2 Blocks protein domains:
    IPB001283 Allergen V5/Tpx-1 related
    IPB013871 Cysteine-rich secretory protein


    UniProtKB/Swiss-Prot: CRIS2_HUMAN, P16562
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain
    Similarity: Contains 1 ShKT domain


    CRISP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRIS2_HUMAN, P16562
    Function: May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation
    (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRISP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISP2

    miRNA
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    Block miRNA regulation of human, mouse, rat CRISP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRISP2
    SwitchGear 3'UTR luciferase reporter plasmidCRISP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRISP2

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    Sino Biological Human cDNA Clone for CRISP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRIS2_HUMAN, P16562: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8665901

    CRISP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRISP2
    Interactions:

        Search GeneGlobe Interaction Network for CRISP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CRISP2 (ENSP000003391554) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2R1AENSP000003248044STRING: ENSP00000324804
    PPP2R1BENSP000003113444STRING: ENSP00000311344
    BMPERENSP000002971614STRING: ENSP00000297161
    CRIM1ENSP000002805274STRING: ENSP00000280527
    KRTAP9-1ENSP000003814884STRING: ENSP00000381488
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--

    CRISP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRISP2 (CRIS2)

    1 HMDB Compound for CRISP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for CRISP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    helothermine 96.1 1 17589791 (1)
    cysteine 34.4 7 12459257 (2), 18550510 (1)



    CRISP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRISP2 gene (6 alternative transcripts): 
    NM_001142407.2  NM_001142408.2  NM_001142417.2  NM_001142435.2  NM_001261822.1  NM_003296.3  

    Unigene Cluster for CRISP2:

    Cysteine-rich secretory protein 2
    Hs.2042  [show with all ESTs]
    Unigene Representative Sequence: AK128009
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000339139(uc003ozq.2 uc003ozl.2 uc003ozn.2 uc003ozr.2 uc003ozo.2 uc003ozm.2 uc003ozp.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat CRISP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRISP2
    SwitchGear 3'UTR luciferase reporter plasmidCRISP2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): CRISP2 (NM_001142408)
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      QuantiTect SYBR Green Assays in human, mouse, rat CRISP2
      QuantiFast Probe-based Assays in human, mouse, rat CRISP2

    Additional mRNA sequence: 

    AK128009.1 AK223337.1 AK292385.1 AY289796.1 AY292862.1 AY292863.1 AY773479.1 BC022011.2 
    BC107707.1 M25532.1 X95239.1 

    10 DOTS entries:

    DT.456110  DT.92419469  DT.95322277  DT.99953716  DT.100775909  DT.101971934  DT.121328804  DT.95322272 
    DT.95322274  DT.95322276 

    Selected AceView cDNA sequences (see all 108):

    BP371676 BM552843 BC022011 BP369384 AY292863 BP371735 BP369666 BX094644 
    AK128009 BP371084 BX105227 BP371599 BI826697 AY292862 BP371367 BP369949 
    BI830025 BI464420 BI828463 X95239 AI635353 BI830127 BP370008 BG721420 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRISP2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                        -                                                                 -               
    SP2:                                                        -                                                                 -               
    SP3:                                                  -     -           -                                                                     
    SP4:                                                  -     -                                                                 -               
    SP5:                                                  -     -           -                                                     -               


    ECgene alternative splicing isoforms for CRISP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRISP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAAGAAGA
    CRISP2 Expression
    About this image


    CRISP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    CRISP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRISP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2042

    UniProtKB/Swiss-Prot: CRIS2_HUMAN, P16562
    Tissue specificity: Testis and epididymis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRISP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crisp21 , 5 cysteine-rich secretory protein 21, 5 78.06(n)1
    70.89(a)1
      17 (19.54 cM)5
    220241  NM_001204071.11  NP_001191000.11 
     407647345 
    chicken
    (Gallus gallus)
    Aves CRISP21 cysteine-rich secretory protein 2 61.23(n)
    54.51(a)
      422045  XM_004935913.1  XP_004935970.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    51(a)
    50(a)
    many ↔ many
    many ↔ many
    1(121628264-121655431)
    1(121596101-121610603)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005365001 cysteine-rich venom protein natrin-1-like 51.24(n)
    41.92(a)
      100536500  XM_003200271.2  XP_003200319.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0090851 AgaP_AGAP009085 47.72(n)
    41.08(a)
      1280040  XM_319834.4  XP_319834.4 


    ENSEMBL Gene Tree for CRISP2 (if available)
    TreeFam Gene Tree for CRISP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRISP2 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  PI152  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for CRISP2 using alignment to 1 protein entry:     CRIS2_HUMAN:
    CRISP3    CRISP1    GLIPR1    GLIPR1L1    PI16

    CRISP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRISP2 (see all 494)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561795161,2
    C--49395102(+) TGTGT-/GTTTTAC 6 -- int11Minor allele frequency- GT:0.00NA 2
    rs3605601,2
    C,F,A,H--49659634(-) GAAAGT/GTTATT 6 -- ds500111Minor allele frequency- G:0.33NS EA NA WA CSA 784
    rs1872331,2
    C,F,O,A,H--49659703(-) GTAACA/GACAGG 6 -- ds500113Minor allele frequency- G:0.22NS EA WA NA CSA 2278
    rs1449238951,2
    --49659713(+) CCAACA/CTAATA 6 -- ds50010--------
    rs2008077651,2
    --49659732(+) TCCAC-/TTGT  
            
    TTGTT
    6 -- ds50010--------
    rs1812092551,2
    --49659790(+) TTTTCA/C/GTTGGC 6 -- ds50010--------
    rs3605591,2
    C,F,A,H--49659871(+) TGATTC/AATTTT 6 -- ds500127Minor allele frequency- A:0.34NS EA NA WA CSA 2470
    rs1138568081,2
    C--49660071(+) ACAACC/G/TGCAGA 12 -- ut311CSA 1
    rs1858904231,2
    --49660080(+) GATGTA/GAAGCT 6 -- ut310--------
    rs1898183481,2
    C--49660104(+) TTATGC/TAAGTA 6 -- ut310--------

    HapMap Linkage Disequilibrium report for CRISP2 (49660072 - 49681299 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CRISP2: --
    Human Gene Mutation Database (HGMD): CRISP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187430    OMIM disorders: --

    8 diseases for CRISP2:    
    About MalaCards
    orchitis    epididymitis    male infertility    atopic dermatitis
    infertility    sinusitis    dermatitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for CRISP2:
    Epididymitis     Orchitis

    CRISP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRISP2
    Human Genome Epidemiology (HuGE) Navigator: CRISP2 (1 document)

    Export disorders for CRISP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRISP2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CRISP2)
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    1. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)1, 2, 3, 9 Kraetzschmar J.... Schleuning W.-D. (Eur. J. Biochem. 1996)
    2. Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. (PubMed id 2613236)1, 2, 3 Kasahara M.... Goodfellow P.N. (Genomics 1989)
    3. Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. (PubMed id 18550510)1, 4, 9 Jamsai D....O'Bryan M.K. (Hum. Reprod. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment. (PubMed id 23661501)1 Nimlamool W....Lowe-Krentz L.J. (Mol. Reprod. Dev. 2013)
    7. Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. (PubMed id 23027975)1 Choudhary V. and Schneiter R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. [Expressions of cysteine-rich secretory protein 2 in asthenospermia]. (PubMed id 21485539)1 Jing X.W....Mao X.M. (Zhonghua Nan Ke Xue 2011)
    9. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. (PubMed id 20625511)1 Plager D.A....Kita H. (PLoS ONE 2010)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7180 HGNC: 12024 AceView: CRISP2 Ensembl:ENSG00000124490 euGenes: HUgn7180
    ECgene: CRISP2 H-InvDB: CRISP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRISP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRISP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRISP2 gene:
    Search GeneIP for patents involving CRISP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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