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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRISP1 Gene

protein-coding   GIFtS: 49
GCID: GC06M049848

Cysteine-Rich Secretory Protein 1

(Previous name: acidic epididymal glycoprotein-like 1)
(Previous symbol: AEGL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteine-Rich Secretory Protein 11 2     AEG-Like Protein2 3
AEGL11 2 3 5     HSCRISP1D2
Acidic Epididymal Glycoprotein-Like 11 2     HSCRISP1G2
Acidic Epididymal Glycoprotein Homolog2 3     HUMARP2
ARP2 3     AEG-Related Protein2
CRISP-12 3     Cysteine-Rich Secretory Protein-1 Delta2

External Ids:    HGNC: 3041   Entrez Gene: 1672   Ensembl: ENSG000001248127   OMIM: 6011935   UniProtKB: P541073   

Export aliases for CRISP1 gene to outside databases

Previous GC identifers: GC06M049803 GC06M049909 GC06M049532


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRISP1 Gene:
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and
egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules
that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal
region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is
a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted
into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in
sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for CRISP1 Gene: 
CRISP1 (cysteine-rich secretory protein 1) is a protein-coding gene. Diseases associated with CRISP1 include epididymitis, and azoospermia. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
Function: May have a role in sperm-egg fusion and maturation

Gene Wiki entry for CRISP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRISP1 gene promoter:
         HSF1 (long)   FOXD1   FOXL1   POU2F1   HSF2   POU2F1b   POU2F1a   HSF1short   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRISP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRISP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.2-p21.1

CRISP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049848:  view genomic region     (about GC identifiers)

Start:
49,801,970 bp from pter      End:
49,844,809 bp from pter
Size:
42,840 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein 1 precursor  
Size: 249 amino acids; 28481 Da
Subcellular location: Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts,
and on the postacrosomal region of the sperm head
Secondary accessions: B5BU98 O00698 Q13248 Q14082 Q96SF6
Alternative splicing: 2 isoforms:  P54107-1   P54107-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRISP1: NX_P54107

Explore proteomics data for CRISP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54107

  • CRISP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRISP1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001122.2  NP_001192149.1  NP_733758.1  

    ENSEMBL proteins: 
     ENSP00000425020   ENSP00000338276   ENSP00000427589   ENSP00000348044   ENSP00000331317  
     ENSP00000441798  

    Human Recombinant Protein Products for CRISP1: 
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    Novus Biologicals CRISP1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRISP1
    Cloud-Clone Corp. Proteins for CRISP1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8543280

    CRISP1 for ontologies           About GeneDecksing



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    Assay Products for CRISP1: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRISP1 
    Cloud-Clone Corp. CLIAs for CRISP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR002413 V5_allergen
     IPR018244 Allrgn_V5/Tpx1_CS
     IPR013871 Cysteine_rich_secretory

    Graphical View of Domain Structure for InterPro Entry P54107

    ProtoNet protein and cluster: P54107

    2 Blocks protein domains:
    IPB001283 Allergen V5/Tpx-1 related
    IPB013871 Cysteine-rich secretory protein


    UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain
    Similarity: Contains 1 ShKT domain


    CRISP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRIS1_HUMAN, P54107
    Function: May have a role in sperm-egg fusion and maturation

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crisp4):

     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    CRISP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crisp4tm1.2Mkob for CRISP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRISP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRISP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRISP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISP1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCRISP1 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRISP1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007342fusion of sperm to egg plasma membrane TAS8838800

    CRISP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRISP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRISP1 (CRIS1)

    3 Novoseek inferred chemical compound relationships for CRISP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    helothermine 93.5 3 17589791 (2), 9115720 (1)
    testosterone 33.4 7 2351105 (1), 11223178 (1)
    cysteine 7.76 2 10386818 (2)

    Search CenterWatch for drugs/clinical trials and news about CRISP1 / CRIS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRISP1 gene (3 alternative transcripts): 
    NM_001131.2  NM_001205220.1  NM_170609.1  

    Unigene Cluster for CRISP1:

    Cysteine-rich secretory protein 1
    Hs.109620  [show with all ESTs]
    Unigene Representative Sequence: NM_001205220
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507853 ENST00000335847(uc003ozw.2 uc003ozx.2 uc021zaj.1)
    ENST00000505118 ENST00000355791 ENST00000329411 ENST00000536021
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CRISP1
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRISP1
    Clone
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    OriGene ORF clones in mouse, rat for CRISP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CRISP1 (NM_170609)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP1
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                         Customized lentivirus expression plasmids for stable overexpression of CRISP1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRISP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRISP1

    Additional mRNA sequence: 

    AB451334.1 AB451479.1 AK292497.1 BC028577.1 BC131707.1 D38451.1 S80310.1 X95237.1 
    X95238.1 

    3 DOTS entries:

    DT.209161  DT.95149233  DT.91810081 

    19 AceView cDNA sequences:

    NM_001131 X95237 H48937 BX089589 AA960912 NM_170609 D38451 X95238 
    BC028577 AI972844 S80310 AW183241 BG719216 BV200168 BV202013 AI797872 
    AA919002 AI208980 BM422390 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CRISP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                
    SP2:                                      -         


    ECgene alternative splicing isoforms for CRISP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRISP1 expression in normal human tissues (normalized intensities)      CRISP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRISP1 Expression
    About this image


    CRISP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             epididymis ; glandular cells   
             sperm   
     
     Smooth Muscle (Muscoskeletal System)
             smooth muscle ; smooth muscle cells   
     
     Pancreas (Endocrine System)
             pancreas ; exocrine glandular cells   
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             kidney ; cells in tubules   

    See CRISP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRISP1

    SOURCE GeneReport for Unigene cluster: Hs.109620

    UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
    Tissue specificity: Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal
    plasma

        SABiosciences Custom PCR Arrays for CRISP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRISP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crisp41 , 5 cysteine-rich secretory protein 41, 5 72.04(n)1
    61.69(a)1
      1 (5.65 cM)5
    780811  NM_030033.11  NP_084309.11 
     181151915 
    lizard
    (Anolis carolinensis)
    Reptilia CRISP16
    --
    (see all 6)
    --
    40(a)
    39(a)
    (see all 6)
    1 ↔ 1
    possible ortholog
    (see all 6)
    1(121685347-121702449)
    1(183618155-183714721)
    zebrafish
    (Danio rerio)
    Actinopterygii CRISP36
    cysteine-rich secretory protein 3
    38(a)
    1 → many
    16(52339308-52358047)
    worm
    (Caenorhabditis elegans)
    Secernentea scl-26
    scl-146
    (see all 21)
    Protein SCL-14
    (see all 21)
    27(a)
    27(a)
    (see all 21)
    many ↔ many
    many ↔ many
    (see all 21)
    IV(13057678-13059092)
    IV(13165516-13166755)


    ENSEMBL Gene Tree for CRISP1 (if available)
    TreeFam Gene Tree for CRISP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRISP1 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    3 SIMAP similar genes for CRISP1 using alignment to 1 protein entry:     CRIS1_HUMAN:
    CRISP3    CRISP2    GLIPR1

    CRISP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/980 SNPs in CRISP1 are shown (see all 980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104987791,2
    C,F,H--49801612(+) ATTTCG/AGCTAT 3 -- ds500124Minor allele frequency- A:0.12NS NA EA WA CSA 2280
    rs168798371,2
    C,F,H--49801659(+) CACTGT/CTCTCC 3 -- ds500110Minor allele frequency- C:0.06NA NS EA WA CSA 684
    rs1917409021,2
    --49801674(+) GTTAAA/TATGTC 3 -- ds50010--------
    rs176638811,2
    C,F,H--49801677(+) AATATG/ATCCAT 3 -- ds50018Minor allele frequency- A:0.07NA NS EA 682
    rs1162713511,2
    C,F--49801704(+) ATTACT/CCAAAA 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1828280231,2
    --49801814(+) AATGGA/GAAGAC 3 -- ds50010--------
    rs1879807671,2
    --49801822(+) GACATC/GGGTCA 3 -- ds50010--------
    rs1926027851,2
    --49801823(+) ACATGG/TGTCAT 3 -- ds50010--------
    rs1844464041,2
    --49801840(+) AGGGCA/GTCATT 3 -- ds50010--------
    rs1510996551,2
    --49801894(+) CCTGTA/GACGAG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRISP1 (49801970 - 49844809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRISP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5294CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601193    OMIM disorders: --

    4 diseases for CRISP1:    About MalaCards
    epididymitis    azoospermia    alopecia    prostatitis


    CRISP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRISP1

    Export disorders for CRISP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRISP1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CRISP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). (PubMed id 8838800)1, 2, 3, 9 Hayashi M.... Kasahara M. (1996)
    2. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)1, 2, 9 Kraetzschmar J.... Schleuning W.-D. (1996)
    3. Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization. (PubMed id 8543280)1, 2, 9 Hayashi M. (1995)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PubMed id 12206465)1, 9 Evans J.P. (2002)
    6. Molecular characterization of epididymal proteins. (PubMed id 9685187)1, 9 Kirchhoff C. (1998)
    7. Vasectomy affects cysteine-rich secretory protein exp ression along the human epididymis and its association with ejaculated spermato zoa following vasectomy surgical reversal. (PubMed id 20378925)1 LAcgarAc C....Sullivan R. (2010)
    8. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg. (PubMed id 11566719)1 Cohen D.J....Cuasnicu P.S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 167 HGNC: 304 AceView: CRISP1 Ensembl:ENSG00000124812 euGenes: HUgn167
    ECgene: CRISP1 H-InvDB: CRISP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRISP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRISP1 gene:
    Search GeneIP for patents involving CRISP1

    GeneCards and IP:
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