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Aliases for CRISP1 Gene

Aliases for CRISP1 Gene

  • Cysteine-Rich Secretory Protein 1 2 3
  • AEGL1 3 4 6
  • Acidic Epididymal Glycoprotein Homolog 3 4
  • Acidic Epididymal Glycoprotein-Like 1 2 3
  • AEG-Like Protein 3 4
  • CRISP-1 3 4
  • ARP 3 4
  • Cysteine-Rich Secretory Protein-1 Delta 3
  • AEG-Related Protein 3
  • HUMARP 3

External Ids for CRISP1 Gene

Previous HGNC Symbols for CRISP1 Gene

  • AEGL1

Previous GeneCards Identifiers for CRISP1 Gene

  • GC06M049803
  • GC06M049848
  • GC06M049532

Summaries for CRISP1 Gene

Entrez Gene Summary for CRISP1 Gene

  • Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for CRISP1 Gene

CRISP1 (Cysteine-Rich Secretory Protein 1) is a Protein Coding gene. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for CRISP1 Gene

  • May have a role in sperm-egg fusion and maturation

Gene Wiki entry for CRISP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRISP1 Gene

Genomics for CRISP1 Gene

Regulatory Elements for CRISP1 Gene

Genomic Location for CRISP1 Gene

49,834,257 bp from pter
49,877,096 bp from pter
42,840 bases
Minus strand

Genomic View for CRISP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRISP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRISP1 Gene

Proteins for CRISP1 Gene

  • Protein details for CRISP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich secretory protein 1
    Protein Accession:
    Secondary Accessions:
    • B5BU98
    • O00698
    • Q13248
    • Q14082
    • Q96SF6

    Protein attributes for CRISP1 Gene

    249 amino acids
    Molecular mass:
    28481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRISP1 Gene


neXtProt entry for CRISP1 Gene

Proteomics data for CRISP1 Gene at MOPED

Post-translational modifications for CRISP1 Gene

  • Glycosylation at Asn230
  • Modification sites at PhosphoSitePlus

Other Protein References for CRISP1 Gene

No data available for DME Specific Peptides for CRISP1 Gene

Domains for CRISP1 Gene

Suggested Antigen Peptide Sequences for CRISP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P54107
  • Contains 1 SCP domain.
  • Contains 1 ShKT domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with CRISP1: view

No data available for Gene Families for CRISP1 Gene

Function for CRISP1 Gene

Molecular function for CRISP1 Gene

UniProtKB/Swiss-Prot Function: May have a role in sperm-egg fusion and maturation

Gene Ontology (GO) - Molecular Function for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IEA --
genes like me logo Genes that share ontologies with CRISP1: view
genes like me logo Genes that share phenotypes with CRISP1: view

Animal Models for CRISP1 Gene

MGI Knock Outs for CRISP1:

miRNA for CRISP1 Gene

miRTarBase miRNAs that target CRISP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRISP1 Gene

Localization for CRISP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRISP1 Gene

Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.

Subcellular locations from

Jensen Localization Image for CRISP1 Gene COMPARTMENTS Subcellular localization image for CRISP1 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8543280
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with CRISP1: view

Pathways for CRISP1 Gene

SuperPathways for CRISP1 Gene

No Data Available

Interacting Proteins for CRISP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338276 for CRISP1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CRISP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0007342 fusion of sperm to egg plasma membrane TAS 8838800
GO:0060046 regulation of acrosome reaction IEA --
genes like me logo Genes that share ontologies with CRISP1: view

No data available for Pathways by source for CRISP1 Gene

Compounds for CRISP1 Gene

(3) Novoseek inferred chemical compound relationships for CRISP1 Gene

Compound -log(P) Hits PubMed IDs
helothermine 93.5 3
testosterone 33.4 2
cysteine 7.76 2
genes like me logo Genes that share compounds with CRISP1: view

Transcripts for CRISP1 Gene

Unigene Clusters for CRISP1 Gene

Cysteine-rich secretory protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRISP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP2: -

Relevant External Links for CRISP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRISP1 Gene

mRNA expression in normal human tissues for CRISP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRISP1 Gene

This gene is overexpressed in Testis (47.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRISP1 Gene

SOURCE GeneReport for Unigene cluster for CRISP1 Gene Hs.109620

mRNA Expression by UniProt/SwissProt for CRISP1 Gene

Tissue specificity: Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma
genes like me logo Genes that share expressions with CRISP1: view

Orthologs for CRISP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRISP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRISP1 35
  • 99.33 (n)
  • 98.8 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CRISP1 35
  • 76.65 (n)
  • 65.18 (a)
  • 65 (a)
(Canis familiaris)
Mammalia CRISP1 35
  • 77.46 (n)
  • 61.94 (a)
  • 64 (a)
(Mus musculus)
Mammalia Crisp4 35
  • 71.51 (n)
  • 61.69 (a)
Crisp4 16
Crisp4 36
  • 61 (a)
(Monodelphis domestica)
Mammalia CRISP1 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia CRISP1 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Crisp4 35
  • 71.62 (n)
  • 63.05 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
-- 36
  • 36 (a)
-- 36
  • 38 (a)
(Danio rerio)
Actinopterygii CRISP3 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
CSA.10077 36
  • 14 (a)
Species with no ortholog for CRISP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRISP1 Gene

Gene Tree for CRISP1 (if available)
Gene Tree for CRISP1 (if available)

Paralogs for CRISP1 Gene

Selected SIMAP similar genes for CRISP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRISP1: view

Variants for CRISP1 Gene

Sequence variations from dbSNP and Humsavar for CRISP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs780555 -- 49,834,361(+) TATTT(C/T)TAGCC utr-variant-3-prime
rs780556 -- 49,834,984(+) GAAGG(A/C/T)GGGGG utr-variant-3-prime
rs780780 -- 49,861,739(-) ccttg(A/C)taata intron-variant
rs780781 -- 49,858,407(-) TGCTT(G/T)CTTTT intron-variant
rs780782 -- 49,850,957(+) ATTTT(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRISP1 Gene

Variant ID Type Subtype PubMed ID
nsv5294 CNV Loss 18451855

Relevant External Links for CRISP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRISP1 Gene

Disorders for CRISP1 Gene

Relevant External Links for CRISP1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CRISP1: view

No data available for UniProtKB/Swiss-Prot for CRISP1 Gene

Publications for CRISP1 Gene

  1. Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). (PMID: 8838800) Hayashi M. … Kasahara M. (Genomics 1996) 2 3 4 23
  2. Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization. (PMID: 8543280) Hayashi M. (Hokkaido Igaku Zasshi 1995) 3 4 23
  3. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PMID: 8665901) Kraetzschmar J. … Schleuning W.-D. (Eur. J. Biochem. 1996) 3 4 23
  4. Molecular characterization of epididymal proteins. (PMID: 9685187) Kirchhoff C. (Rev. Reprod. 1998) 3 23
  5. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PMID: 12206465) Evans J.P. (Hum. Reprod. Update 2002) 3 23

Products for CRISP1 Gene

Sources for CRISP1 Gene

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