Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CRISP1 Gene

protein-coding   GIFtS: 50
GCID: GC06M049848

Cysteine-Rich Secretory Protein 1

(Previous name: acidic epididymal glycoprotein-like 1)
(Previous symbol: AEGL1)
  Search for CRISP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cysteine-Rich Secretory Protein 11 2     AEG-Like Protein2 3
AEGL11 2 3 5     HSCRISP1D2
Acidic Epididymal Glycoprotein-Like 11 2     HSCRISP1G2
Acidic Epididymal Glycoprotein Homolog2 3     HUMARP2
ARP2 3     AEG-Related Protein2
CRISP-12 3     Cysteine-Rich Secretory Protein-1 Delta2

External Ids:    HGNC: 3041   Entrez Gene: 1672   Ensembl: ENSG000001248127   OMIM: 6011935   UniProtKB: P541073   

Export aliases for CRISP1 gene to outside databases

Previous GC identifers: GC06M049803 GC06M049909 GC06M049532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CRISP1 Gene:
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and
egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules
that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal
region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is
a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted
into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in
sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for CRISP1 Gene:
CRISP1 (cysteine-rich secretory protein 1) is a protein-coding gene. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
Function: May have a role in sperm-egg fusion and maturation

Gene Wiki entry for CRISP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRISP1 gene promoter:
         HSF1 (long)   FOXD1   FOXL1   POU2F1   HSF2   POU2F1b   POU2F1a   HSF1short   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRISP1 promoter sequence
   Search Chromatin IP Primers for CRISP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p21.2-p21.1

CRISP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRISP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M049848:  view genomic region     (about GC identifiers)

Start:
49,801,970 bp from pter      End:
49,844,809 bp from pter
Size:
42,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107 (See protein sequence)
Recommended Name: Cysteine-rich secretory protein 1 precursor  
Size: 249 amino acids; 28481 Da
Secondary accessions: B5BU98 O00698 Q13248 Q14082 Q96SF6
Alternative splicing: 2 isoforms:  P54107-1   P54107-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRISP1: NX_P54107

Explore proteomics data for CRISP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn230

  • See CRISP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001122.2  NP_001192149.1  NP_733758.1  

    ENSEMBL proteins: 
     ENSP00000425020   ENSP00000338276   ENSP00000427589   ENSP00000348044   ENSP00000331317  
     ENSP00000441798  

    CRISP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CRISP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CRISP1
    GenScript Custom Purified and Recombinant Proteins Services for CRISP1
    Novus Biologicals CRISP1 Protein
    Novus Biologicals CRISP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CRISP1
    Cloud-Clone Corp. Proteins for CRISP1

     
    Search eBioscience for Proteins for CRISP1 

    CRISP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRISP1 (CRISP-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRISP1
    Novus Biologicals CRISP1 Antibodies
    Abcam antibodies for CRISP1
    Cloud-Clone Corp. Antibodies for CRISP1
    Search ThermoFisher Antibodies for CRISP1
    LSBio Antibodies in human, mouse, rat for CRISP1

    CRISP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRISP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRISP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRISP1
    Cloud-Clone Corp. CLIAs for CRISP1
    Search eBioscience for ELISAs for CRISP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR002413 V5_allergen
     IPR018244 Allrgn_V5/Tpx1_CS
     IPR003582 ShKT_dom

    Graphical View of Domain Structure for InterPro Entry P54107

    ProtoNet protein and cluster: P54107

    2 Blocks protein domains:
    IPB001283 Allergen V5/Tpx-1 related
    IPB013871 Cysteine-rich secretory protein


    UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain
    Similarity: Contains 1 ShKT domain


    Find genes that share domains with CRISP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRIS1_HUMAN, P54107
    Function: May have a role in sperm-egg fusion and maturation

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crisp4):

     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with CRISP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crisp4tm1.2Mkob for CRISP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRISP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRISP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRISP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRISP1:
    hsa-mir-148b-3p (MIRT019493)

    Block miRNA regulation of human, mouse, rat CRISP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRISP1
    SwitchGear 3'UTR luciferase reporter plasmidCRISP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRISP1
    Predesigned siRNA for gene silencing in human, mouse, rat CRISP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRISP1

    Clone
    Products:
         
    OriGene clones in human, mouse for CRISP1 (see all 10)
    OriGene ORF clones in mouse, rat for CRISP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CRISP1 (NM_170609)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRISP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRISP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CRIS1_HUMAN, P54107: Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts,
    and on the postacrosomal region of the sperm head
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8543280

    Find genes that share ontologies with CRISP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRISP1
    Interactions:

        Search GeneGlobe Interaction Network for CRISP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRISP1 (ENSP000003382764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPERENSP000002971614STRING: ENSP00000297161
    CRIM1ENSP000002805274STRING: ENSP00000280527
    --ENSP000003966644STRING: ENSP00000396664
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007342fusion of sperm to egg plasma membrane TAS8838800

    Find genes that share ontologies with CRISP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRISP1 (CRIS1)

    3 Novoseek inferred chemical compound relationships for CRISP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    helothermine 93.5 3 17589791 (2), 9115720 (1)
    testosterone 33.4 7 2351105 (1), 11223178 (1)
    cysteine 7.76 2 10386818 (2)



    Find genes that share compounds with CRISP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CRISP1 gene (3 alternative transcripts): 
    NM_001131.2  NM_001205220.1  NM_170609.1  

    Unigene Cluster for CRISP1:

    Cysteine-rich secretory protein 1
    Hs.109620  [show with all ESTs]
    Unigene Representative Sequence: NM_001205220
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507853 ENST00000335847(uc003ozw.2 uc003ozx.2 uc021zaj.1)
    ENST00000505118 ENST00000355791 ENST00000329411 ENST00000536021
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRISP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CRISP1
    SwitchGear 3'UTR luciferase reporter plasmidCRISP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRISP1
    Predesigned siRNA for gene silencing in human, mouse, rat CRISP1
    Clone
    Products:
         
    OriGene clones in human, mouse for CRISP1 (see all 10)
    OriGene ORF clones in mouse, rat for CRISP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CRISP1 (NM_170609)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRISP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CRISP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISP1
      QuantiTect SYBR Green Assays in human, mouse, rat CRISP1
      QuantiFast Probe-based Assays in human, mouse, rat CRISP1

    Additional mRNA sequence: 

    AB451334.1 AB451479.1 AK292497.1 BC028577.1 BC131707.1 D38451.1 S80310.1 X95237.1 
    X95238.1 

    3 DOTS entries:

    DT.209161  DT.95149233  DT.91810081 

    19 AceView cDNA sequences:

    H48937 AA960912 NM_170609 BX089589 NM_001131 X95237 X95238 S80310 
    AW183241 BV200168 AI972844 BG719216 BC028577 D38451 BV202013 AA919002 
    AI208980 AI797872 BM422390 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CRISP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                
    SP2:                                      -         


    ECgene alternative splicing isoforms for CRISP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CRISP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRISP1 Expression
    About this image


    CRISP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CRISP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRISP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109620

    UniProtKB/Swiss-Prot: CRIS1_HUMAN, P54107
    Tissue specificity: Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal
    plasma

        Custom PCR Arrays for CRISP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CRISP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISP1
    QuantiTect SYBR Green Assays in human, mouse, rat CRISP1
    QuantiFast Probe-based Assays in human, mouse, rat CRISP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CRISP1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crisp41 , 5 cysteine-rich secretory protein 41, 5 71.51(n)1
    61.69(a)1
      1 (5.65 cM)5
    780811  NM_030033.11  NP_084309.11 
     181151915 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    40(a)
    38(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    1(139702118-139722506)
    1(183618155-183714721)
    zebrafish
    (Danio rerio)
    Actinopterygii CRISP36
    cysteine-rich secretory protein 3
    38(a)
    1 → many
    16(52339308-52358047) ENSDARG00000091103


    ENSEMBL Gene Tree for CRISP1 (if available)
    TreeFam Gene Tree for CRISP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CRISP1 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  PI152  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    3 SIMAP similar genes for CRISP1 using alignment to 1 protein entry:     CRIS1_HUMAN:
    CRISP2    CRISP3    GLIPR1

    Find genes that share paralogs with CRISP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CRISP1 (see all 980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104987791,2
    C,F,H--49801612(+) ATTTCG/AGCTAT 3 -- ds500124Minor allele frequency- A:0.12NS NA EA WA CSA 2280
    rs168798371,2
    C,F,H--49801659(+) CACTGT/CTCTCC 3 -- ds500110Minor allele frequency- C:0.06NA NS EA WA CSA 684
    rs1917409021,2
    --49801674(+) GTTAAA/TATGTC 3 -- ds50010--------
    rs176638811,2
    C,F,H--49801677(+) AATATG/ATCCAT 3 -- ds50018Minor allele frequency- A:0.07NA NS EA 682
    rs1162713511,2
    C,F--49801704(+) ATTACT/CCAAAA 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1828280231,2
    --49801814(+) AATGGA/GAAGAC 3 -- ds50010--------
    rs1879807671,2
    --49801822(+) GACATC/GGGTCA 3 -- ds50010--------
    rs1926027851,2
    --49801823(+) ACATGG/TGTCAT 3 -- ds50010--------
    rs1844464041,2
    --49801840(+) AGGGCA/GTCATT 3 -- ds50010--------
    rs1510996551,2
    --49801894(+) CCTGTA/GACGAG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for CRISP1 (49801970 - 49844809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CRISP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5294CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRISP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRISP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601193    OMIM disorders: --


    Find genes that share disorders with CRISP1           About GenesLikeMe

    Genetic Association Database (GAD): CRISP1

    Export disorders for CRISP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CRISP1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CRISP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). (PubMed id 8838800)1, 2, 3, 9 Hayashi M.... Kasahara M. (Genomics 1996)
    2. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. (PubMed id 8665901)1, 2, 9 Kraetzschmar J.... Schleuning W.-D. (Eur. J. Biochem. 1996)
    3. Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization. (PubMed id 8543280)1, 2, 9 Hayashi M. (Hokkaido Igaku Zasshi 1995)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. The molecular basis of sperm-oocyte membrane interactions during mammalian fertilization. (PubMed id 12206465)1, 9 Evans J.P. (Hum. Reprod. Update 2002)
    6. Molecular characterization of epididymal proteins. (PubMed id 9685187)1, 9 Kirchhoff C. (Rev. Reprod. 1998)
    7. Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia. (PubMed id 23987519)1 LAcgarAc C....Sullivan R. (Fertil. Steril. 2013)
    8. Vasectomy affects cysteine-rich secretory protein expression along the human epididymis and its association with ejaculated spermatozoa following vasectomy surgical reversal. (PubMed id 20378925)1 LAcgarAc C....Sullivan R. (J. Androl. 2010)
    9. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (Nat. Methods 2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 167 HGNC: 304 AceView: CRISP1 Ensembl:ENSG00000124812 euGenes: HUgn167
    ECgene: CRISP1 H-InvDB: CRISP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CRISP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CRISP1 gene:
    Search GeneIP for patents involving CRISP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CRISP1 (CRISP-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CRISP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CRISP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CRISP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRISP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CRISP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRISP1   OriGene Custom Protein Services for CRISP1  

     
     
     Block miRNA regulation of human, mouse, rat CRISP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CRISP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRISP1 Predesigned siRNA for gene silencing in human, mouse, rat CRISP1
     QuantiFast Probe-based Assays in human, mouse, rat CRISP1 QuantiTect SYBR Green Assays in human, mouse, rat CRISP1
     Custom PCR Arrays for CRISP1 Search Chromatin IP Primers for CRISP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRISP1  Search GeneGlobe Interaction Network for CRISP1
     Regulatory tfbs in CRISP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CRISP1 GenScript cDNA clones with any tag delivered in your preferred vector for CRISP1
     GenScript Custom Assay Services for CRISP1 GenScript Custom overexpressing Cell Line Services for CRISP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CRISP1 (CRIS1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CRISP1 antibodies
     CRISP1 proteins
     CRISP1 lysates
     Antibodies for CRISP1
     See all of Abcam's Antibodies, Kits and Proteins for CRISP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CRISP1
     Proteins for CRISP1
     Antibodies for CRISP1
     ELISAs for CRISP1
     CLIAs for CRISP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CRISP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRISP1
     SwitchGear 3'UTR luciferase reporter plasmids for CRISP1
     SwitchGear Promoter luciferase reporter plasmids for CRISP1
     Search ThermoFisher Antibodies for CRISP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRISP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRISP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRISP1
     LSBio Antibodies in human, mouse, rat for CRISP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CRISP1
      Search eBioscience for proteins for CRISP1
      Search eBioscience for elisas for CRISP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRISP1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4