CRIPT Gene
protein-coding GIFtS: 51
GCID: GC02P046843
|
|
cysteine-rich PDZ-binding protein
| |
Aliases
for CRIPT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cysteine-Rich PDZ-Binding Protein1 2 | | Cysteine-Rich Interactor Of PDZ Three2 3 | | Cysteine-Rich Interactor Of PDZ32 3 | | HSPC1391 | | Postsynaptic Protein CRIPT2 |
Export aliases for CRIPT gene to outside databasesPrevious GC identifers: GC02P046862 GC02P047013 GC02P046802 GC02P046818 GC02P046755 GC02P046697 GC02P046581 |
Summaries
for CRIPT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CRIPT_HUMAN, Q9P021Function: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)
Gene Wiki entry for CRIPT
|
Genomic Views
for CRIPT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRIPT gene promoter:
AML1a FOXF2 ATF-2 FOXO3 AP-2gamma MEF-2A AP-2beta aMEF-2 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRIPT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIPT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21CRIPT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P046843: view genomic region
(about GC identifiers)
Start:
|
46,843,555 bp from pter |
End:
|
46,852,881 bp from pter |
Size:
|
9,327 bases |
Orientation:
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plus strand |
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Proteins
for CRIPT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRIPT_HUMAN, Q9P021 (See
protein sequence)Recommended Name: Cysteine-rich PDZ-binding protein Size: 101 amino acids; 11216 Da
Subunit: Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates withmicrotubules (By similarity). Interacts with DLG4
Subcellular location: Cytoplasm (By similarity). Cell junction, synapse (By similarity). Cell projection, dendriticspine (By similarity). Note=Colocalizes with DLG4 in asymmetric synapses (By similarity)Explore the universe of human proteins at neXtProt for CRIPT: NX_Q9P021
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P021
CRIPT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054890.1
ENSEMBL proteins: ENSP00000238892
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CRIPT for ontologies About GeneDecksing
CRIPT Antibody Products:
Assay Products for CRIPT: |
Protein
Domains /
Families
for CRIPT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRIPT for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P021ProtoNet protein and cluster: Q9P021 UniProtKB/Swiss-Prot: CRIPT_HUMAN, Q9P021Similarity: Belongs to the CRIPT family |
Function
for CRIPT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CRIPT_HUMAN, Q9P021Function: Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CRIPT (NM_014171) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIPT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIPT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPT |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CRIPT for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cript):
CRIPT for phenotypes About GeneDecksing
|
Pathways & Interactions
for CRIPT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRIPT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for CRIPT (Q9P0212, 3 ENSP000002388924) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031122 | cytoplasmic microtubule organization |
IEA | -- | | GO:0045184 | establishment of protein localization |
IEA | -- |
CRIPT for ontologies About GeneDecksing
|
Drugs & Compounds
for CRIPT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRIPT
Search CenterWatch for drugs/clinical trials and news about CRIPT
|
Transcripts
for CRIPT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRIPT gene: NM_014171.4 Unigene Cluster for CRIPT: Cysteine-rich PDZ-binding protein Hs.133998 [show with all ESTs]Unigene Representative Sequence: NM_0141712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486447 ENST00000238892(uc002rve.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CRIPT (NM_014171) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIPT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIPT |
Additional cDNA sequence: AF161488.1 AK291298.1 BC006979.1 BC006980.1 BC018653.1 8 DOTS entries: DT.100794881 DT.113202 DT.121012453 DT.100794875 DT.121012513 DT.100794876 DT.97769824 DT.100794877 24/188 AceView cDNA sequences (see all 188): AW292463 BQ267372 BX281639 BM460609 BQ231709 AI572254 AI189393 BU190150 BG149626 AI201748 AI223792 AA283784 BP349579 AA372934 AA461095 AW236961 CK825319 AI912690 BF591360 BQ004496 AA165108 AI073516 BG489402 BM978556
GeneLoc Exon Structure
|
Expression
for CRIPT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRIPT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGAAAAT
About this image
See CRIPT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRIPT
SOURCE GeneReport for Unigene cluster: Hs.133998
SABiosciences Custom PCR Arrays for CRIPT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIPT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRIPT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIPT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIPT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPT |
Orthologs
for CRIPT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CRIPT gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for CRIPT (if available)
TreeFam Gene Tree for CRIPT (if available) |
Paralogs
for CRIPT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRIPT gene
CRIPT for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CRIPT
PGOHUM00000239857
|
Genomic Variants
for CRIPT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRIPT (46843555 - 46852881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRIPT
1 CNV: 3354
Human Gene Mutation Database (HGMD): CRIPT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIPT |
|
Disorders
/ Diseases
for CRIPT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRIPT for disorders About GeneDecksing
OMIM gene information: 604594
OMIM disorders: --
6  diseases for CRIPT: About MalaCardssensory peripheral neuropathy peripheral neuropathy neuropathy ataxia
malaria neuronitis
Human Genome Epidemiology (HuGE) Navigator: CRIPT (2 documents)
Export disorders for CRIPT gene to outside databases
|
Publications
for CRIPT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRIPT gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CRIPT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins. (PubMed id 16091592)1, 3 Fukunaga Y....Miyazawa A. (2005)
- The PDZ1 domain of SAP90. Characterization of structure and binding. (PubMed id 11744724)1, 3 Piserchio A....Mierke D.F. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. (PubMed id 10570482)1, 3 Passafaro M....Sheng M. (1999)
- CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. (PubMed id 9581762)1, 3 Niethammer M....Sheng M. (1998)
- Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1 Saus E....Estivill X. (2010)
- Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1 GratacA^s M....Carracedo A. (2008)
- A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. (PubMed id 17474715)2 Saro D.... Spaller M.R. (2007)
|
External Searches for CRIPT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CRIPT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRIPT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRIPT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CRIPT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CRIPT gene:
Search GeneIP for patents involving CRIPT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRIPT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CRIPT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRIPT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIPT | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CRIPT | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CRIPT | | OriGene Custom Protein Services for CRIPT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRIPT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIPT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIPT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIPT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIPT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIPT |
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| | | | Search Tocris compounds for CRIPT |
| |  |  |  |  | | | | | | Recombinant Protein for CRIPT |
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 | | | CRIPT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPT |
|  |  |  | | | | ThermoFisher Antibodies for CRIPT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIPT |
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