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Aliases for CRIPT Gene

Aliases for CRIPT Gene

  • Cysteine-Rich PDZ-Binding Protein 2 3
  • Cysteine-Rich Interactor Of PDZ Three 3 4
  • Cysteine-Rich Interactor Of PDZ3 3 4
  • Postsynaptic Protein CRIPT 3
  • HSPC139 3
  • SSMDF 3

External Ids for CRIPT Gene

Previous GeneCards Identifiers for CRIPT Gene

  • GC02P046862
  • GC02P047013
  • GC02P046802
  • GC02P046818
  • GC02P046755
  • GC02P046697
  • GC02P046843

Summaries for CRIPT Gene

Entrez Gene Summary for CRIPT Gene

  • This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]

GeneCards Summary for CRIPT Gene

CRIPT (Cysteine-Rich PDZ-Binding Protein) is a Protein Coding gene. Diseases associated with CRIPT include short stature with microcephaly and distinctive facies and growth hormone deficiency, isolated, type ia. GO annotations related to this gene include protein complex binding and PDZ domain binding.

UniProtKB/Swiss-Prot for CRIPT Gene

  • Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.

Gene Wiki entry for CRIPT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIPT Gene

Genomics for CRIPT Gene

Regulatory Elements for CRIPT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRIPT Gene

46,616,416 bp from pter
46,630,176 bp from pter
13,761 bases
Plus strand

Genomic View for CRIPT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIPT Gene

Proteins for CRIPT Gene

  • Protein details for CRIPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich PDZ-binding protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CRIPT Gene

    101 amino acids
    Molecular mass:
    11216 Da
    Quaternary structure:
    • Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4.

neXtProt entry for CRIPT Gene

Proteomics data for CRIPT Gene at MOPED

Post-translational modifications for CRIPT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIPT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRIPT Gene

Domains for CRIPT Gene

Protein Domains for CRIPT Gene


Suggested Antigen Peptide Sequences for CRIPT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P021
  • Belongs to the CRIPT family.
genes like me logo Genes that share domains with CRIPT: view

No data available for Gene Families for CRIPT Gene

Function for CRIPT Gene

Molecular function for CRIPT Gene

UniProtKB/Swiss-Prot Function:
Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.

Gene Ontology (GO) - Molecular Function for CRIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11937501
GO:0008017 microtubule binding ISS --
GO:0030165 PDZ domain binding IDA 17474715
GO:0032403 protein complex binding ISS --
genes like me logo Genes that share ontologies with CRIPT: view

Phenotypes for CRIPT Gene

MGI mutant phenotypes for CRIPT:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CRIPT: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRIPT Gene

Localization for CRIPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIPT Gene

Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine. Note=Colocalizes with DLG4 in asymmetric synapses. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CRIPT Gene COMPARTMENTS Subcellular localization image for CRIPT gene
Compartment Confidence
extracellular 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CRIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0014069 postsynaptic density ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CRIPT: view

Pathways for CRIPT Gene

SuperPathways for CRIPT Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031122 cytoplasmic microtubule organization ISS --
GO:0035372 protein localization to microtubule ISS --
GO:0045184 establishment of protein localization ISS --
GO:1902897 regulation of postsynaptic density protein 95 clustering ISS --
genes like me logo Genes that share ontologies with CRIPT: view

No data available for Pathways by source for CRIPT Gene

Transcripts for CRIPT Gene

mRNA/cDNA for CRIPT Gene

Unigene Clusters for CRIPT Gene

Cysteine-rich PDZ-binding protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIPT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIPT Gene

No ASD Table

Relevant External Links for CRIPT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIPT Gene

mRNA expression in normal human tissues for CRIPT Gene

Protein differential expression in normal tissues for CRIPT Gene

This gene is overexpressed in Breast (31.2) and CD4 Tcells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIPT Gene

SOURCE GeneReport for Unigene cluster for CRIPT Gene Hs.133998

genes like me logo Genes that share expressions with CRIPT: view

Expression partners for CRIPT Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRIPT Gene

Orthologs for CRIPT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CRIPT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRIPT 35
  • 94.06 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia CRIPT 35
  • 96.37 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Cript 35
  • 90.76 (n)
  • 99.01 (a)
Cript 16
Cript 36
  • 99 (a)
(Pan troglodytes)
Mammalia CRIPT 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cript 35
  • 89.44 (n)
  • 99.01 (a)
(Monodelphis domestica)
Mammalia CRIPT 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia CRIPT 36
  • 90 (a)
(Gallus gallus)
Aves CRIPT 35
  • 82.18 (n)
  • 96.04 (a)
  • 96 (a)
(Anolis carolinensis)
Reptilia CRIPT 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cript 35
  • 80.2 (n)
  • 94.06 (a)
Str.1099 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14004 35
(Danio rerio)
Actinopterygii cript 35
  • 77.23 (n)
  • 93.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4537 37
  • 60 (a)
CG4537 35
  • 58.68 (n)
  • 62.5 (a)
CG4537 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010721 35
  • 68 (n)
  • 76 (a)
(Caenorhabditis elegans)
Secernentea C36B1.14 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61780 35
  • 62.24 (n)
  • 68.37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7291 35
(Hordeum vulgare)
Liliopsida Hv.667 35
(Oryza sativa)
Liliopsida Os08g0190800 35
  • 61.86 (n)
  • 68.04 (a)
(Zea mays)
Liliopsida Zm.8100 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4340 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3282 36
  • 68 (a)
Species with no ortholog for CRIPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIPT Gene

Gene Tree for CRIPT (if available)
Gene Tree for CRIPT (if available)

Paralogs for CRIPT Gene Pseudogenes for CRIPT Gene

genes like me logo Genes that share paralogs with CRIPT: view

No data available for Paralogs for CRIPT Gene

Variants for CRIPT Gene

Sequence variations from dbSNP and Humsavar for CRIPT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8390 -- 46,624,728(-) TCTAG(A/G)TTAAT utr-variant-3-prime
rs1080871 -- 46,627,569(+) ctccc(A/G)accta utr-variant-3-prime
rs1080872 -- 46,627,558(+) catgc(A/C)tcagc utr-variant-3-prime
rs1456010 -- 46,628,658(+) TGGCC(A/G)CACTT utr-variant-3-prime
rs1598517 -- 46,630,262(-) gtaat(A/G)ttact downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CRIPT Gene

Variant ID Type Subtype PubMed ID
dgv1181e1 CNV Complex 17122850
nsv873996 CNV Gain 21882294
nsv873997 CNV Loss 21882294

Relevant External Links for CRIPT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIPT Gene

Disorders for CRIPT Gene


  • Short stature with microcephaly and distinctive facies (SSMF) [MIM:615789]: A disease characterized by dwarfism, microcephaly, and distinctive facial dysmorphism involving frontal bossing, high forehead, sparse hair and eyebrows, telecanthus, mild proptosis, anteverted nares, and flat nasal bridge. {ECO:0000269 PubMed:24389050}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CRIPT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRIPT: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CRIPT Gene

Publications for CRIPT Gene

  1. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. (PMID: 9581762) Niethammer M. … Sheng M. (Neuron 1998) 2 3
  2. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. (PMID: 10570482) Passafaro M. … Sheng M. (Nat. Neurosci. 1999) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. The PDZ1 domain of SAP90. Characterization of structure and binding. (PMID: 11744724) Piserchio A. … Mierke D.F. (J. Biol. Chem. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CRIPT Gene

Sources for CRIPT Gene

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