CRIPAK Gene
protein-coding GIFtS: 40
GCID: GC04P001385
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cysteine-rich PAK1 inhibitor(Previous name: cysteine-rich PAK1inhibitor )
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Aliases
for CRIPAK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cysteine-Rich PAK1 Inhibitor1 2 | | FLJ344431 | | Cysteine-Rich PAK1inhibitor1 | | Cysteine-Rich Inhibitor Of PAK12 | | CRIPak3 |
Export aliases for CRIPAK gene to outside databasesPrevious GC identifer: GC04P001378 |
Summaries
for CRIPAK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CRIPAK:
CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 (PubMed16278681)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CRPAK_HUMAN, Q8N1N5Function: Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contributeto hormonal independence
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Genomic Views
for CRIPAK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRIPAK gene promoter:
C/EBPbeta Pax-6 Brachyury GATA-1 YY1 E2F-1 E2F HOXA5 FOXO4 Chx10
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRIPAK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIPAK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3CRIPAK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P001385: view genomic region
(about GC identifiers)
Start:
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1,385,340 bp from pter |
End:
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1,389,782 bp from pter |
Size:
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4,443 bases |
Orientation:
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plus strand |
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Proteins
for CRIPAK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRPAK_HUMAN, Q8N1N5 (See
protein sequence)Recommended Name: Cysteine-rich PAK1 inhibitor Size: 446 amino acids; 48076 Da
Subunit: Interacts with PAK1
Subcellular location: Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonaltreatment by estrogen
Secondary accessions: Q8NB03Explore the universe of human proteins at neXtProt for CRIPAK: NX_Q8N1N5
CRIPAK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_787114.2
ENSEMBL proteins: ENSP00000323978
Human Recombinant Protein Products for CRIPAK:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CRIPAK for ontologies About GeneDecksing
CRIPAK Antibody Products:
Assay Products for CRIPAK: |
Protein
Domains /
Families
for CRIPAK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRIPAK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N1N5ProtoNet protein and cluster: Q8N1N5 |
Function
for CRIPAK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CRPAK_HUMAN, Q8N1N5Function: Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contributeto hormonal independenceInduction: Up-regulated by estrogen Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CRIPAK for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CRIPAK:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CRIPAK (NM_175918) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIPAK | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRIPAK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPAK |
|
Pathways & Interactions
for CRIPAK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRIPAK
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CRIPAK (Q8N1N51, 3 ENSP000003239784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CRIPAK for ontologies About GeneDecksing
|
Drugs & Compounds
for CRIPAK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRIPAK
Search CenterWatch for drugs/clinical trials and news about CRIPAK / CRPAK
|
Transcripts
for CRIPAK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRIPAK gene: NM_175918.3 Unigene Cluster for CRIPAK: Cysteine-rich PAK1 inhibitor Hs.26410 [show with all ESTs]Unigene Representative Sequence: NM_1759181 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000324803(uc003gdf.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CRIPAK (NM_175918) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIPAK | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRIPAK |
Additional cDNA sequence: AK091762.1 AK096209.1 AK126919.1 3 DOTS entries: DT.100021373 DT.209617 DT.99958367 24/46 AceView cDNA sequences (see all 46): AL043834 AK091762 AX747170 AW088580 BU623980 BG231499 AL045049 CA420525 N62916 Z39442 AK096209 BM982683 BX116238 NM_175918 CD558065 AK126919 BE018394 AA479350 R55327 CA425154 AW166990 AI571136 CK000202 AI274611
GeneLoc Exon Structure
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Expression
for CRIPAK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRIPAK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGCTGATT
About this image
See CRIPAK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRIPAK
SOURCE GeneReport for Unigene cluster: Hs.26410
UniProtKB/Swiss-Prot: CRPAK_HUMAN, Q8N1N5Tissue specificity: Widely expressed with a highest expression observed in trachea, prostate and adrenal glands.Expressed in many cancer cell lines including breast cancer cells
SABiosciences Custom PCR Arrays for CRIPAK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIPAK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CRIPAK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIPAK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIPAK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPAK |
Orthologs
for CRIPAK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for CRIPAK (if available)
TreeFam Gene Tree for CRIPAK (if available) |
Paralogs
for CRIPAK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CRIPAK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CRIPAK (1385340 - 1389782 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CRIPAK
3 CNVs: 68610 36199 68609 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIPAK |
|
Disorders
/ Diseases
for CRIPAK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRIPAK for disorders About GeneDecksing
OMIM gene information: 610203
OMIM disorders: --
2  diseases for CRIPAK: About MalaCardsbreast cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: CRIPAK (1 document)
Export disorders for CRIPAK gene to outside databases
|
Publications
for CRIPAK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRIPAK gene integrated from 9 sources:
(articles sorted by number of sources associating them with CRIPAK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CRIPak, a novel endogenous Pak1 inhibitor. (PubMed id 16278681)1, 2, 3 Talukder A.H....Kumar R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CRIPAK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CRIPAK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRIPAK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRIPAK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CRIPAK | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CRIPAK gene:
Search GeneIP for patents involving CRIPAK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRIPAK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CRIPAK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRIPAK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIPAK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for CRIPAK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIPAK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | CRIPAK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIPAK |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRIPAK |
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