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Aliases for CRIPAK Gene

Aliases for CRIPAK Gene

  • Cysteine-Rich PAK1 Inhibitor 2 3
  • Cysteine-Rich PAK1inhibitor 2
  • FLJ3443 6
  • CRIPak 4

External Ids for CRIPAK Gene

Summaries for CRIPAK Gene

Entrez Gene Summary for CRIPAK Gene

  • CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIPAK Gene

CRIPAK (Cysteine-Rich PAK1 Inhibitor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CRIPAK Gene

  • Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIPAK Gene

Genomics for CRIPAK Gene

Genomic Location for CRIPAK Gene

Start:
1,391,552 bp from pter
End:
1,395,994 bp from pter
Size:
4,443 bases
Orientation:
Plus strand

Genomic View for CRIPAK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIPAK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIPAK Gene

Regulatory Elements for CRIPAK Gene

Proteins for CRIPAK Gene

  • Protein details for CRIPAK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1N5-CRPAK_HUMAN
    Recommended name:
    Cysteine-rich PAK1 inhibitor
    Protein Accession:
    Q8N1N5
    Secondary Accessions:
    • Q8NB03

    Protein attributes for CRIPAK Gene

    Size:
    446 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    • Interacts with PAK1.

neXtProt entry for CRIPAK Gene

Proteomics data for CRIPAK Gene at MOPED

Post-translational modifications for CRIPAK Gene

No Post-translational modifications

Other Protein References for CRIPAK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRIPAK Gene

Domains for CRIPAK Gene

Protein Domains for CRIPAK Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CRIPAK: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CRIPAK Gene

Function for CRIPAK Gene

Molecular function for CRIPAK Gene

UniProtKB/Swiss-Prot Function: Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.
UniProtKB/Swiss-Prot Induction: Up-regulated by estrogen.

Gene Ontology (GO) - Molecular Function for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16278681
genes like me logo Genes that share ontologies with CRIPAK: view

Phenotypes for CRIPAK Gene

genes like me logo Genes that share phenotypes with CRIPAK: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRIPAK Gene

Localization for CRIPAK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIPAK Gene

Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonal treatment by estrogen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIPAK Gene COMPARTMENTS Subcellular localization image for CRIPAK gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16278681
GO:0005737 cytoplasm IDA 16278681
GO:0005783 endoplasmic reticulum IDA 16278681
GO:0005886 plasma membrane IDA 16278681
genes like me logo Genes that share ontologies with CRIPAK: view

Pathways for CRIPAK Gene

SuperPathways for CRIPAK Gene

No Data Available

Interacting Proteins for CRIPAK Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323978%0d%0a9606.ENSP00000278568%0d%0a9606.ENSP00000206249%0d%0a
Selected Interacting proteins: ENSP00000323978 Q8N1N5-CRPAK_HUMAN for CRIPAK Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CRIPAK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 16278681
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA 16278681
GO:0043627 response to estrogen IDA 16278681
GO:0051493 regulation of cytoskeleton organization IDA 16278681
genes like me logo Genes that share ontologies with CRIPAK: view

No data available for Pathways by source for CRIPAK Gene

Transcripts for CRIPAK Gene

mRNA/cDNA for CRIPAK Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRIPAK Gene

Cysteine-rich PAK1 inhibitor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRIPAK Gene

No ASD Table

Relevant External Links for CRIPAK Gene

GeneLoc Exon Structure for
CRIPAK
ECgene alternative splicing isoforms for
CRIPAK

Expression for CRIPAK Gene

mRNA expression in normal human tissues for CRIPAK Gene

SOURCE GeneReport for Unigene cluster for CRIPAK Gene Hs.26410

mRNA Expression by UniProt/SwissProt for CRIPAK Gene

Q8N1N5-CRPAK_HUMAN
Tissue specificity: Widely expressed with a highest expression observed in trachea, prostate and adrenal glands. Expressed in many cancer cell lines including breast cancer cells.
genes like me logo Genes that share expressions with CRIPAK: view

Orthologs for CRIPAK Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CRIPAK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRIPAK 36
  • 92.72 (n)
  • 89.68 (a)
CRIPAK 37
  • 86 (a)
OneToOne
Species with no ortholog for CRIPAK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRIPAK Gene

ENSEMBL:
Gene Tree for CRIPAK (if available)
TreeFam:
Gene Tree for CRIPAK (if available)

Paralogs for CRIPAK Gene

No data available for Paralogs for CRIPAK Gene

Variants for CRIPAK Gene

Sequence variations from dbSNP and Humsavar for CRIPAK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13097 -, - 1,394,777(-) CGGCA(C/T)ATGTG missense, reference
rs1140009 -- 1,395,460(+) CCCAT(A/G)TGGAG reference, missense
rs1140010 -- 1,395,474(+) CCGCC(C/T)GCTCA synonymous-codon, reference
rs1140011 -- 1,395,535(+) TGCCC(A/G)CCTGC missense, reference
rs3210561 -- 1,394,658(+) ATGCC(C/G)ATGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CRIPAK Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv878328 CNV Loss 21882294
nsv878330 CNV Loss 21882294
dgv5405n71 CNV Loss 21882294
nsv878344 CNV Loss 21882294
nsv878345 CNV Loss 21882294
nsv878347 CNV Loss 21882294
nsv878350 CNV Loss 21882294
nsv878351 CNV Loss 21882294
nsv4197 CNV Insertion 18451855
esv2726793 CNV Deletion 23290073
esv1697030 CNV Deletion 17803354
esv21856 CNV Gain+Loss 19812545

Relevant External Links for CRIPAK Gene

HapMap Linkage Disequilibrium report
CRIPAK

Disorders for CRIPAK Gene

Relevant External Links for CRIPAK

Genetic Association Database (GAD)
CRIPAK
Human Genome Epidemiology (HuGE) Navigator
CRIPAK
genes like me logo Genes that share disorders with CRIPAK: view

No data available for UniProtKB/Swiss-Prot for CRIPAK Gene

Publications for CRIPAK Gene

  1. CRIPak, a novel endogenous Pak1 inhibitor. (PMID: 16278681) Talukder A.H. … Kumar R. (Oncogene 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for CRIPAK Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CRIPAK
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CRIPAK
    • Block miRNA regulation of CRIPAK using miScript Target Protectors

    Sources for CRIPAK Gene

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