CRIP3 Gene
protein-coding GIFtS: 40
GCID: GC06M043267
|
|
cysteine-rich protein 3
| |
Aliases
for CRIP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cysteine-Rich Protein 31 2 | | CRP-32 3 | | TLP1 2 | | H6LIMo1 | | TLP-A1 2 | | Thymus LIM Protein TLP-A2 | | BA480N24.21 | | CRP33 | | Chromosome 6 LIM Domain Only Protein2 3 | | |
Export aliases for CRIP3 gene to outside databasesPrevious GC identifers: GC00U914157 GC06U900618 GC06M043382 GC06M042991 |
Summaries
for CRIP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CRIP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRIP3 gene promoter:
E2F-4 E2F-3a NF-1/L E2F-5 NF-1 Nkx2-5 XBP-1 E2F-2 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRIP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21CRIP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M043267: view genomic region
(about GC identifiers)
Start:
|
43,267,448 bp from pter |
End:
|
43,276,535 bp from pter |
Size:
|
9,088 bases |
Orientation:
|
minus strand |
|
Proteins
for CRIP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRIP3_HUMAN, Q6Q6R5 (See
protein sequence)Recommended Name: Cysteine-rich protein 3 Size: 217 amino acids; 24088 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A2A436 Q5T043 Q6Q6R4 Q6Q6R6 Q6Q6R7Alternative splicing: 4 isoforms: Q6Q6R5-1 Q6Q6R5-2 Q6Q6R5-3 Q6Q6R5-4 Explore the universe of human proteins at neXtProt for CRIP3: NX_Q6Q6R5
CRIP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_996805.2
ENSEMBL proteins: ENSP00000414553 ENSP00000361650 ENSP00000397775 ENSP00000274990
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CRIP3 for ontologies About GeneDecksing
CRIP3 Antibody Products:
Assay Products for CRIP3: |
Protein
Domains /
Families
for CRIP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRIP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6Q6R5ProtoNet protein and cluster: Q6Q6R5 1 Blocks protein family: IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: CRIP3_HUMAN, Q6Q6R5Similarity: Contains 2 LIM zinc-binding domains |
Function
for CRIP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CRIP3 (NM_206922) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIP3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
CRIP3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CRIP3:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Crip3):
CRIP3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CRIP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRIP3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042098 | T cell proliferation |
IEA | -- |
CRIP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CRIP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRIP3
Search CenterWatch for drugs/clinical trials and news about CRIP3
|
Transcripts
for CRIP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRIP3 gene: NM_206922.2 Unigene Cluster for CRIP3: Cysteine-rich protein 3 Hs.653165 [show with all ESTs]Unigene Representative Sequence: AK1246577 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416431 ENST00000372569(uc003ouu.1) ENST00000451294 ENST00000477866
ENST00000274990(uc010jyn.2) ENST00000487744 ENST00000485819
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CRIP3 (NM_206922) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRIP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIP3 |
Additional cDNA sequence: AK124657.1 AY555741.1 AY555742.1 AY555743.1 AY555744.1 BC068247.1 8 DOTS entries: DT.100019750 DT.100666858 DT.97801718 DT.121405507 DT.443865 DT.91739223 DT.102837846 DT.95153325 24/202 AceView cDNA sequences (see all 202): AA865024 BU736591 BQ002909 AI651081 BI917114 CA429114 BE551519 AA885056 AA429316 AW274372 T05190 BQ083317 BM704270 AA482194 BU521261 AI989980 AA380339 BP363088 BM671433 AI656764 BC030687 AI917610 AI345982 BM727284
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CRIP3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CRIP3
|
Expression
for CRIP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRIP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CRIP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRIP3
SOURCE GeneReport for Unigene cluster: Hs.653165
UniProtKB/Swiss-Prot: CRIP3_HUMAN, Q6Q6R5Tissue specificity: Expressed in most tissues, but not in skeletal muscle
SABiosciences Custom PCR Arrays for CRIP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRIP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIP3 |
Orthologs
for CRIP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CRIP3 gene from 1/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5565151 |
cysteine-rich protein 3-like |
67.01(n)
73.1(a) |
|
556515 XM_679338.4 XP_684430.1 |
ENSEMBL Gene Tree for CRIP3 (if available)
TreeFam Gene Tree for CRIP3 (if available) |
Paralogs
for CRIP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRIP3 gene
- CSRP22 CSRP12 CRIP22 ENSG000002573412 CRIP12 CSRP32
6 SIMAP similar genes for CRIP3 using alignment to 3 protein entries: CRIP3_HUMAN (see all proteins):CRIP1 CRIP2 DKFZp686P2249 CSRP1 CSRP2 CSRP3
CRIP3 for paralogs About GeneDecksing
|
Genomic Variants
for CRIP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRIP3 (43267448 - 43276535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRIP3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIP3 |
|
Disorders
/ Diseases
for CRIP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CRIP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRIP3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CRIP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. (PubMed id 15380775)1, 2, 3 Casrouge A.... Kanellopoulos J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for CRIP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CRIP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRIP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRIP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CRIP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CRIP3 gene:
Search GeneIP for patents involving CRIP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRIP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CRIP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRIP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIP3 | | | OriGene Protein Over-expression Lysate for CRIP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CRIP3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CRIP3 | | OriGene Custom Protein Services for CRIP3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRIP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIP3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CRIP3 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CRIP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIP3 |
|  |  |  | | | | ThermoFisher Antibodies for CRIP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIP3 |
|
|
|
|
