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Aliases for CRIP3 Gene

Aliases for CRIP3 Gene

  • Cysteine Rich Protein 3 2 3 5
  • Chromosome 6 LIM Domain Only Protein 3 4
  • H6LIMo 3 4
  • CRP-3 3 4
  • Thymus LIM Protein TLP-A 3
  • Cysteine-Rich Protein 3 3
  • BA480N24.2 3
  • TLP-A 3
  • CRP3 4
  • TLP 3

External Ids for CRIP3 Gene

Previous GeneCards Identifiers for CRIP3 Gene

  • GC00U914157
  • GC06U900618
  • GC06M043382
  • GC06M043267
  • GC06M042991

Summaries for CRIP3 Gene

GeneCards Summary for CRIP3 Gene

CRIP3 (Cysteine Rich Protein 3) is a Protein Coding gene. An important paralog of this gene is CRIP2.

Additional gene information for CRIP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP3 Gene

Genomics for CRIP3 Gene

Regulatory Elements for CRIP3 Gene

Enhancers for CRIP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043390 1.5 Ensembl ENCODE dbSUPER 11.2 -82.8 -82839 3.5 HDGF PKNOX1 ARNT TCF12 ZNF766 GATA2 ZNF592 SMARCA4 GLIS1 PBX2 ABCC10 CRIP3 RPL12P47 DLK2 TTBK1 DNPH1 POLR1C YIPF3 LRRC73 ZNF318
GH06H043382 1.4 Ensembl ENCODE dbSUPER 11.2 -74.2 -74245 2.7 PKNOX1 TBL1XR1 BMI1 YBX1 BATF YY1 FOS ATF7 ETV6 RUNX3 SLC22A7 ABCC10 RPL12P47 CRIP3 DLK2 TTBK1 DNPH1 RNU6-1113P TJAP1 LRRC73
GH06H043261 1.3 FANTOM5 ENCODE dbSUPER 11.5 +47.2 47249 1.4 ELF3 SAP130 CEBPG RAD21 ZIC2 ZNF644 ZSCAN9 RARA TEAD3 GLIS2 DNPH1 SLC22A7 ZNF318 RPL12P47 CRIP3 DLK2 ENSG00000245261 CUL9 YIPF3 LRRC73
GH06H043334 1.1 Ensembl ENCODE 12.2 -25.7 -25672 1.8 ELF3 PKNOX1 ARID4B DMAP1 ZBTB40 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 SLC22A7 RPL12P47 CRIP3 ZNF318 DLK2 LRRC73 POLR1C YIPF3 RPL34P14 GC06P043362
GH06H043376 1 ENCODE dbSUPER 10.6 -67.2 -67164 0.9 BMI1 EBF1 BATF RELA FOSL1 EED FOS ETV6 RUNX3 IKZF2 RNU6-1113P TJAP1 DLK2 RPL12P47 CRIP3 POLR1C LRRC73 YIPF3 ZNF318 GC06P043382
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRIP3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CRIP3 Gene

Genomic Locations for CRIP3 Gene
9,905 bases
Minus strand

Genomic View for CRIP3 Gene

Genes around CRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP3 Gene

Proteins for CRIP3 Gene

  • Protein details for CRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 3
    Protein Accession:
    Secondary Accessions:
    • A2A436
    • Q5T043
    • Q6Q6R4
    • Q6Q6R6
    • Q6Q6R7

    Protein attributes for CRIP3 Gene

    217 amino acids
    Molecular mass:
    24088 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRIP3 Gene


neXtProt entry for CRIP3 Gene

Post-translational modifications for CRIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIP3 Gene

No data available for DME Specific Peptides for CRIP3 Gene

Domains & Families for CRIP3 Gene

Gene Families for CRIP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CRIP3 Gene


Suggested Antigen Peptide Sequences for CRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRIP3: view

No data available for UniProtKB/Swiss-Prot for CRIP3 Gene

Function for CRIP3 Gene

Phenotypes From GWAS Catalog for CRIP3 Gene

Gene Ontology (GO) - Molecular Function for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP3: view
genes like me logo Genes that share phenotypes with CRIP3: view

Animal Models for CRIP3 Gene

MGI Knock Outs for CRIP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP3 Gene

Localization for CRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIP3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIP3 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CRIP3: view

Pathways & Interactions for CRIP3 Gene

SuperPathways for CRIP3 Gene

No Data Available

Interacting Proteins for CRIP3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361650 Q6Q6R5-CRIP3_HUMAN for CRIP3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CRIP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRIP3 Gene

Drugs & Compounds for CRIP3 Gene

No Compound Related Data Available

Transcripts for CRIP3 Gene

Unigene Clusters for CRIP3 Gene

Cysteine-rich protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -

Relevant External Links for CRIP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRIP3 Gene

mRNA differential expression in normal tissues according to GTEx for CRIP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for CRIP3 Gene

This gene is overexpressed in Platelet (46.2) and Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRIP3 Gene

Protein tissue co-expression partners for CRIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRIP3 Gene:


SOURCE GeneReport for Unigene cluster for CRIP3 Gene:


mRNA Expression by UniProt/SwissProt for CRIP3 Gene:

Tissue specificity: Expressed in most tissues, but not in skeletal muscle.
genes like me logo Genes that share expression patterns with CRIP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP3 Gene

Orthologs for CRIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRIP3 33 34
  • 99.67 (n)
(Canis familiaris)
Mammalia CRIP3 33 34
  • 92.16 (n)
(Bos Taurus)
Mammalia CRIP3 33 34
  • 90.2 (n)
(Rattus norvegicus)
Mammalia Crip3 33
  • 88.4 (n)
(Mus musculus)
Mammalia Crip3 33 16 34
  • 88.07 (n)
(Monodelphis domestica)
Mammalia CRIP3 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CRIP3 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crip3 33
  • 69.02 (n)
(Danio rerio)
Actinopterygii CRIP3 34
  • 68 (a)
LOC556515 33
  • 66.67 (n)
(Caenorhabditis elegans)
Secernentea valv-1 34
  • 52 (a)
exc-9 34
  • 48 (a)
Species where no ortholog for CRIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP3 Gene

Gene Tree for CRIP3 (if available)
Gene Tree for CRIP3 (if available)

Paralogs for CRIP3 Gene

Paralogs for CRIP3 Gene

(6) SIMAP similar genes for CRIP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRIP3: view

Variants for CRIP3 Gene

Sequence variations from dbSNP and Humsavar for CRIP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000368292 -- 43,311,020(+) TATCT(A/G)TATGA upstream-variant-2KB
rs1002130301 -- 43,306,679(+) CCCTC(C/T)GACTC intron-variant
rs1002162974 -- 43,306,956(+) AATGA(C/T)TCCTC intron-variant
rs1002798038 -- 43,309,582(+) ACTTT(A/G)GGAGG upstream-variant-2KB, utr-variant-5-prime
rs1002870266 -- 43,309,870(+) TTTCT(A/T)ATCTG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CRIP3 Gene

Variant ID Type Subtype PubMed ID
nsv970114 CNV duplication 23825009
nsv950170 CNV deletion 24416366
nsv602999 CNV loss 21841781
nsv602998 CNV loss 21841781
nsv1017398 CNV gain 25217958

Variation tolerance for CRIP3 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP3 Gene

Disorders for CRIP3 Gene

Relevant External Links for CRIP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRIP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP3 Gene

Publications for CRIP3 Gene

  1. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. (PMID: 15380775) Casrouge A … Kanellopoulos J (Microbes and infection 2004) 2 3 4 60
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 60

Products for CRIP3 Gene

Sources for CRIP3 Gene

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