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Aliases for CRIP3 Gene

Aliases for CRIP3 Gene

  • Cysteine-Rich Protein 3 2 3
  • Chromosome 6 LIM Domain Only Protein 3 4
  • H6LIMo 3 4
  • CRP-3 3 4
  • Thymus LIM Protein TLP-A 3
  • BA480N24.2 3
  • TLP-A 3
  • CRP3 4
  • TLP 3

External Ids for CRIP3 Gene

Previous GeneCards Identifiers for CRIP3 Gene

  • GC00U914157
  • GC06U900618
  • GC06M043382
  • GC06M043267
  • GC06M042991

Summaries for CRIP3 Gene

GeneCards Summary for CRIP3 Gene

CRIP3 (Cysteine-Rich Protein 3) is a Protein Coding gene. Diseases associated with CRIP3 include cardiomyopathy, dilated, 1m and cardiomyopathy, hypertrophic, 12. An important paralog of this gene is CSRP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP3 Gene

Genomics for CRIP3 Gene

Regulatory Elements for CRIP3 Gene

Genomic Location for CRIP3 Gene

Chromosome:
6
Start:
43,299,710 bp from pter
End:
43,309,614 bp from pter
Size:
9,905 bases
Orientation:
Minus strand

Genomic View for CRIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP3 Gene

Proteins for CRIP3 Gene

  • Protein details for CRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q6R5-CRIP3_HUMAN
    Recommended name:
    Cysteine-rich protein 3
    Protein Accession:
    Q6Q6R5
    Secondary Accessions:
    • A2A436
    • Q5T043
    • Q6Q6R4
    • Q6Q6R6
    • Q6Q6R7

    Protein attributes for CRIP3 Gene

    Size:
    217 amino acids
    Molecular mass:
    24088 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CRIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRIP3 Gene

Proteomics data for CRIP3 Gene at MOPED

Post-translational modifications for CRIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIP3 Gene

No data available for DME Specific Peptides for CRIP3 Gene

Domains & Families for CRIP3 Gene

Protein Domains for CRIP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6Q6R5

UniProtKB/Swiss-Prot:

CRIP3_HUMAN :
  • Contains 2 LIM zinc-binding domains.
Domain:
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CRIP3: view

No data available for Gene Families for CRIP3 Gene

Function for CRIP3 Gene

Gene Ontology (GO) - Molecular Function for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CRIP3: view

Phenotypes for CRIP3 Gene

genes like me logo Genes that share phenotypes with CRIP3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP3 Gene

Localization for CRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIP3 Gene COMPARTMENTS Subcellular localization image for CRIP3 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for CRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CRIP3: view

Pathways & Interactions for CRIP3 Gene

SuperPathways for CRIP3 Gene

No Data Available

Interacting Proteins for CRIP3 Gene

Gene Ontology (GO) - Biological Process for CRIP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRIP3 Gene

Drugs & Compounds for CRIP3 Gene

No Compound Related Data Available

Transcripts for CRIP3 Gene

Unigene Clusters for CRIP3 Gene

Cysteine-rich protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for CRIP3 Gene

GeneLoc Exon Structure for
CRIP3
ECgene alternative splicing isoforms for
CRIP3

Expression for CRIP3 Gene

mRNA expression in normal human tissues for CRIP3 Gene

mRNA differential expression in normal tissues according to GTEx for CRIP3 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for CRIP3 Gene

This gene is overexpressed in Platelet (46.2) and Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRIP3 Gene



SOURCE GeneReport for Unigene cluster for CRIP3 Gene Hs.653165

mRNA Expression by UniProt/SwissProt for CRIP3 Gene

Q6Q6R5-CRIP3_HUMAN
Tissue specificity: Expressed in most tissues, but not in skeletal muscle.
genes like me logo Genes that share expression patterns with CRIP3: view

Protein tissue co-expression partners for CRIP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRIP3 Gene

Orthologs for CRIP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRIP3 35
  • 90.2 (n)
  • 92.16 (a)
CRIP3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRIP3 35
  • 92.16 (n)
  • 94.61 (a)
CRIP3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crip3 35
  • 88.07 (n)
  • 88.24 (a)
Crip3 16
Crip3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRIP3 35
  • 99.67 (n)
  • 99.51 (a)
CRIP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crip3 35
  • 88.4 (n)
  • 88.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CRIP3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRIP3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crip3 35
  • 69.02 (n)
  • 72.73 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC556515 35
  • 66.67 (n)
  • 71.07 (a)
CRIP3 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exc-9 36
  • 48 (a)
ManyToMany
valv-1 36
  • 52 (a)
ManyToMany
Species with no ortholog for CRIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP3 Gene

ENSEMBL:
Gene Tree for CRIP3 (if available)
TreeFam:
Gene Tree for CRIP3 (if available)

Paralogs for CRIP3 Gene

Paralogs for CRIP3 Gene

(6) SIMAP similar genes for CRIP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRIP3: view

Variants for CRIP3 Gene

Sequence variations from dbSNP and Humsavar for CRIP3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2254303 -- 43,308,652(-) AGACA(C/T)CCTTT intron-variant
rs2841644 -- 43,306,306(-) GAGAA(A/G)GTGAT synonymous-codon, reference
rs4521574 -- 43,311,454(+) tggct(C/T)acgcc upstream-variant-2KB
rs12193537 -- 43,308,650(+) GAAAA(C/G)GGTGT intron-variant
rs34999886 -- 43,310,404(+) GGTGG(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRIP3 Gene

Variant ID Type Subtype PubMed ID
dgv6840n71 CNV Loss 21882294

Variation tolerance for CRIP3 Gene

Residual Variation Intolerance Score: 54.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIP3 Gene

HapMap Linkage Disequilibrium report
CRIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP3 Gene

Disorders for CRIP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CRIP3 Gene - From: OMIM

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1m
  • cmd1m
cardiomyopathy, hypertrophic, 12
  • cardiomyopathy, familial hypertrophic, 12
- elite association
Search CRIP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRIP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRIP3
genes like me logo Genes that share disorders with CRIP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRIP3 Gene

Publications for CRIP3 Gene

  1. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. (PMID: 15380775) Casrouge A. … Kanellopoulos J. (Microbes Infect. 2004) 2 67
  2. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 67
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 67

Products for CRIP3 Gene

Sources for CRIP3 Gene

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