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Aliases for CRIP2 Gene

Aliases for CRIP2 Gene

  • Cysteine Rich Protein 2 2 3
  • CRP2 3 4
  • Cysteine-Rich Intestinal Protein 3
  • LIM Domain Protein ESP1/CRP2 3
  • Cysteine-Rich Protein 2 5
  • Protein ESP1 4
  • CRP-2 4
  • ESP1 3
  • CRIP 3

External Ids for CRIP2 Gene

Previous GeneCards Identifiers for CRIP2 Gene

  • GC14U990010
  • GC14P099932
  • GC14P103911
  • GC14P103912
  • GC14P105012
  • GC14P105939
  • GC14P086136

Summaries for CRIP2 Gene

Entrez Gene Summary for CRIP2 Gene

  • This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for CRIP2 Gene

CRIP2 (Cysteine Rich Protein 2) is a Protein Coding gene. Diseases associated with CRIP2 include Gliosarcoma. An important paralog of this gene is CSRP1.

Gene Wiki entry for CRIP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP2 Gene

Genomics for CRIP2 Gene

Regulatory Elements for CRIP2 Gene

Enhancers for CRIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRIP2 Gene

105,472,938 bp from pter
105,480,170 bp from pter
7,233 bases
Plus strand

Genomic View for CRIP2 Gene

Genes around CRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP2 Gene

Proteins for CRIP2 Gene

  • Protein details for CRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 2
    Protein Accession:
    Secondary Accessions:
    • A1A4U1
    • B7Z6C0
    • E9PD13

    Protein attributes for CRIP2 Gene

    208 amino acids
    Molecular mass:
    22493 Da
    Quaternary structure:
    • Interacts with TGFB1I1.

    Three dimensional structures from OCA and Proteopedia for CRIP2 Gene

    Alternative splice isoforms for CRIP2 Gene


neXtProt entry for CRIP2 Gene

Proteomics data for CRIP2 Gene at MOPED

Post-translational modifications for CRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIP2 Gene

No data available for DME Specific Peptides for CRIP2 Gene

Domains & Families for CRIP2 Gene

Gene Families for CRIP2 Gene

Protein Domains for CRIP2 Gene


Suggested Antigen Peptide Sequences for CRIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LIM zinc-binding domains.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CRIP2: view

Function for CRIP2 Gene

Molecular function for CRIP2 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 2

Phenotypes for CRIP2 Gene

GenomeRNAi human phenotypes for CRIP2:
genes like me logo Genes that share phenotypes with CRIP2: view

Animal Model Products

miRNA for CRIP2 Gene

miRTarBase miRNAs that target CRIP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRIP2 Gene

Localization for CRIP2 Gene

Subcellular locations from

Jensen Localization Image for CRIP2 Gene COMPARTMENTS Subcellular localization image for CRIP2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRIP2 Gene

Pathways & Interactions for CRIP2 Gene

SuperPathways for CRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRIP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CRIP2 Gene

Drugs & Compounds for CRIP2 Gene

(1) Drugs for CRIP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CRIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRIP2: view

Transcripts for CRIP2 Gene

Unigene Clusters for CRIP2 Gene

Cysteine-rich protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - -

Relevant External Links for CRIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIP2 Gene

mRNA expression in normal human tissues for CRIP2 Gene

mRNA differential expression in normal tissues according to GTEx for CRIP2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.8) and Heart - Left Ventricle (x5.6).

Protein differential expression in normal tissues from HIPED for CRIP2 Gene

This gene is overexpressed in Hair follicle (9.4) and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIP2 Gene

SOURCE GeneReport for Unigene cluster for CRIP2 Gene Hs.534309

mRNA Expression by UniProt/SwissProt for CRIP2 Gene

Tissue specificity: Widespread tissue expression; highest levels in the heart.
genes like me logo Genes that share expression patterns with CRIP2: view

Protein tissue co-expression partners for CRIP2 Gene

Primer Products

Orthologs for CRIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRIP2 35
  • 89.74 (n)
  • 93.75 (a)
(Canis familiaris)
Mammalia CRIP2 35
  • 88.46 (n)
  • 95.19 (a)
CRIP2 36
  • 91 (a)
(Rattus norvegicus)
Mammalia RGD1563606 35
  • 84.65 (n)
  • 87.62 (a)
(Monodelphis domestica)
Mammalia CRIP2 36
  • 86 (a)
(Mus musculus)
Mammalia Crip2 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia CRIP2 36
  • 63 (a)
(Pan troglodytes)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves CRIP2 36
  • 81 (a)
(Anolis carolinensis)
Reptilia CRIP2 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28352 35
(Danio rerio)
Actinopterygii crip2 35
  • 70.71 (n)
  • 77.18 (a)
Dr.5660 35
crip2 36
  • 72 (a)
zgc:101840 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9800 35
(Caenorhabditis elegans)
Secernentea exc-9 36
  • 58 (a)
valv-1 36
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7243 35
Species with no ortholog for CRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CRIP2 Gene

Gene Tree for CRIP2 (if available)
Gene Tree for CRIP2 (if available)

Paralogs for CRIP2 Gene

Paralogs for CRIP2 Gene

(14) SIMAP similar genes for CRIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRIP2: view

Variants for CRIP2 Gene

Sequence variations from dbSNP and Humsavar for CRIP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7493964 -- 105,477,662(+) GTGTG(G/T)GGGGA intron-variant
rs8007663 -- 105,472,502(+) TGAGT(A/G/T)GCAGG upstream-variant-2KB
rs8008091 -- 105,472,545(+) GAAGG(C/G)ACCAG upstream-variant-2KB
rs8008685 -- 105,472,328(+) TGCTT(C/T)CTGCA upstream-variant-2KB
rs35569103 -- 105,472,262(+) ATGAA(-/A)GGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
dgv659e1 CNV Complex 17122850
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
nsv832890 CNV Loss 17160897
nsv817647 CNV Gain 17921354
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2036n71 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
dgv2038n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138
nsv902492 CNV Loss 21882294
dgv2039n71 CNV Loss 21882294
nsv1440 CNV Insertion 18451855
esv21791 CNV Loss 19812545
nsv9177 CNV Gain 18304495
esv1004211 CNV Insertion 20482838
nsv513421 CNV Insertion 21212237
esv1077360 CNV Deletion 17803354
esv2749298 CNV Deletion 23290073

Variation tolerance for CRIP2 Gene

Gene Damage Index Score: 0.99; 20.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CRIP2 Gene

Disorders for CRIP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRIP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search CRIP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRIP2 Gene

Publications for CRIP2 Gene

  1. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. (PMID: 8843343) Tsui S.K.W. … Lee C.Y. (Biochem. Mol. Biol. Int. 1996) 2 3 4 67
  2. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. (PMID: 12839623) van Ham M. … Hendriks W. (Genes Cells 2003) 3 23
  3. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. (PMID: 10681529) Huber A. … Allescher H.D. (J. Biol. Chem. 2000) 2 3
  4. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. (PMID: 8824798) Karim M.A. … Indo Y. (Genomics 1996) 3 23
  5. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. (PMID: 25865307) Scifo E. … Lalowski M. (J Proteomics 2015) 3

Products for CRIP2 Gene

Sources for CRIP2 Gene