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Aliases for CRIP2 Gene

Aliases for CRIP2 Gene

  • Cysteine-Rich Protein 2 2 3
  • CRP2 3 4 6
  • Cysteine-Rich Intestinal Protein 3
  • LIM Domain Protein ESP1/CRP2 3
  • Protein ESP1 4
  • CRP-2 4
  • CRIP 3
  • ESP1 3

External Ids for CRIP2 Gene

Previous GeneCards Identifiers for CRIP2 Gene

  • GC14U990010
  • GC14P099932
  • GC14P103911
  • GC14P103912
  • GC14P105012
  • GC14P105939
  • GC14P086136

Summaries for CRIP2 Gene

Entrez Gene Summary for CRIP2 Gene

  • This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for CRIP2 Gene

CRIP2 (Cysteine-Rich Protein 2) is a Protein Coding gene. An important paralog of this gene is CSRP1.

Gene Wiki entry for CRIP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP2 Gene

Genomics for CRIP2 Gene

Regulatory Elements for CRIP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRIP2 Gene

105,472,938 bp from pter
105,480,170 bp from pter
7,233 bases
Plus strand

Genomic View for CRIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP2 Gene

Proteins for CRIP2 Gene

  • Protein details for CRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 2
    Protein Accession:
    Secondary Accessions:
    • A1A4U1
    • B7Z6C0
    • E9PD13

    Protein attributes for CRIP2 Gene

    208 amino acids
    Molecular mass:
    22493 Da
    Quaternary structure:
    • Interacts with TGFB1I1.

    Three dimensional structures from OCA and Proteopedia for CRIP2 Gene

    Alternative splice isoforms for CRIP2 Gene


neXtProt entry for CRIP2 Gene

Proteomics data for CRIP2 Gene at MOPED

Post-translational modifications for CRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRIP2 Gene

Antibody Products

No data available for DME Specific Peptides for CRIP2 Gene

Domains for CRIP2 Gene

Protein Domains for CRIP2 Gene


Suggested Antigen Peptide Sequences for CRIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LIM zinc-binding domains.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with CRIP2: view

No data available for Gene Families for CRIP2 Gene

Function for CRIP2 Gene

Molecular function for CRIP2 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 2

Gene Ontology (GO) - Molecular Function for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CRIP2: view

Animal Model Products

miRNA for CRIP2 Gene

miRTarBase miRNAs that target CRIP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRIP2 Gene

Localization for CRIP2 Gene

Subcellular locations from

Jensen Localization Image for CRIP2 Gene COMPARTMENTS Subcellular localization image for CRIP2 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005938 cell cortex IEA --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with CRIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP2 Gene

Pathways for CRIP2 Gene

SuperPathways for CRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with CRIP2: view

No data available for Pathways by source for CRIP2 Gene

Compounds for CRIP2 Gene

(2) Novoseek inferred chemical compound relationships for CRIP2 Gene

Compound -log(P) Hits PubMed IDs
zinc 52.4 8
hydrogen 11.1 1
genes like me logo Genes that share compounds with CRIP2: view

Transcripts for CRIP2 Gene

Unigene Clusters for CRIP2 Gene

Cysteine-rich protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - -
SP7: - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - -

Relevant External Links for CRIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIP2 Gene

mRNA expression in normal human tissues for CRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRIP2 Gene

This gene is overexpressed in Heart - Atrial Appendage (5.8) and Heart - Left Ventricle (5.6).

Protein differential expression in normal tissues for CRIP2 Gene

This gene is overexpressed in Hair follicle (9.4) and Fetal heart (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIP2 Gene

SOURCE GeneReport for Unigene cluster for CRIP2 Gene Hs.534309

mRNA Expression by UniProt/SwissProt for CRIP2 Gene

Tissue specificity: Widespread tissue expression; highest levels in the heart
genes like me logo Genes that share expressions with CRIP2: view

Expression partners for CRIP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CRIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRIP2 35
  • 89.74 (n)
  • 93.75 (a)
(Canis familiaris)
Mammalia CRIP2 35
  • 88.46 (n)
  • 95.19 (a)
CRIP2 36
  • 91 (a)
(Rattus norvegicus)
Mammalia RGD1563606 35
  • 84.65 (n)
  • 87.62 (a)
(Mus musculus)
Mammalia Crip2 16
Crip2 36
  • 88 (a)
(Monodelphis domestica)
Mammalia CRIP2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CRIP2 36
  • 63 (a)
(Pan troglodytes)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves CRIP2 36
  • 81 (a)
(Anolis carolinensis)
Reptilia CRIP2 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28352 35
(Danio rerio)
Actinopterygii crip2 35
  • 70.71 (n)
  • 77.18 (a)
Dr.5660 35
crip2 36
  • 72 (a)
zgc:101840 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9800 35
(Caenorhabditis elegans)
Secernentea exc-9 36
  • 58 (a)
valv-1 36
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7243 35
Species with no ortholog for CRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CRIP2 Gene

Gene Tree for CRIP2 (if available)
Gene Tree for CRIP2 (if available)

Paralogs for CRIP2 Gene

Paralogs for CRIP2 Gene

(14) SIMAP similar genes for CRIP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRIP2: view

Variants for CRIP2 Gene

Sequence variations from dbSNP and Humsavar for CRIP2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1130427 -- 105,480,043(+) TGGCA(A/G)AGGGC utr-variant-3-prime, nc-transcript-variant
rs1140329 -- 105,480,101(+) TCGCC(A/C)CCCTC utr-variant-3-prime, nc-transcript-variant
rs4983418 -- 105,477,342(+) CCAGG(A/G)GCATT intron-variant, nc-transcript-variant
rs4983419 -- 105,480,505(+) TGGAG(A/G)AAAGT downstream-variant-500B
rs7493964 -- 105,477,662(+) GTGTG(G/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
dgv659e1 CNV Complex 17122850
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
nsv832890 CNV Loss 17160897
nsv817647 CNV Gain 17921354
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2036n71 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
dgv2038n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138
nsv902492 CNV Loss 21882294
dgv2039n71 CNV Loss 21882294
nsv1440 CNV Insertion 18451855
esv21791 CNV Loss 19812545
nsv9177 CNV Gain 18304495
esv1004211 CNV Insertion 20482838
nsv513421 CNV Insertion 21212237
esv1077360 CNV Deletion 17803354
esv2749298 CNV Deletion 23290073

Relevant External Links for CRIP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP2 Gene

Disorders for CRIP2 Gene

(1) University of Copenhagen DISEASES for CRIP2 Gene

genes like me logo Genes that share disorders with CRIP2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CRIP2 Gene

Publications for CRIP2 Gene

  1. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. (PMID: 8824798) Karim M.A. … Indo Y. (Genomics 1996) 3 4 23
  2. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. (PMID: 8843343) Tsui S.K.W. … Lee C.Y. (Biochem. Mol. Biol. Int. 1996) 2 3 4
  3. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. (PMID: 10681529) Huber A. … Allescher H.D. (J. Biol. Chem. 2000) 2 3
  4. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. (PMID: 12839623) van Ham M. … Hendriks W. (Genes Cells 2003) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CRIP2 Gene

Sources for CRIP2 Gene

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