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CRIP2 Gene

protein-coding   GIFtS: 56
GCID: GC14P105939

Cysteine-Rich Protein 2

  Search for CRIP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cysteine-Rich Protein 21 2     Cysteine-Rich Intestinal Protein2
CRP22 3 5     LIM Domain Protein ESP1/CRP22
CRIP2     CRP-23
ESP12     Protein ESP13

External Ids:    HGNC: 23611   Entrez Gene: 13972   Ensembl: ENSG000001828097   OMIM: 6011835   UniProtKB: P529433   
ORGUL members:         

Export aliases for CRIP2 gene to outside databases

Previous GC identifers: GC14U990010 GC14P099932 GC14P103911 GC14P103912 GC14P105012 GC14P086136


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRIP2 Gene:
This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may
participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for CRIP2 Gene:
CRIP2 (cysteine-rich protein 2) is a protein-coding gene. An important paralog of this gene is CSRP2.

Gene Wiki entry for CRIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRIP2 gene promoter:
         NF-1   Pax-5   NRSF form 1   Lmo2   MyoD   CUTL1   NRSF form 2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRIP2 promoter sequence
   Search Chromatin IP Primers for CRIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.3

CRIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRIP2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P105939:  view genomic region     (about GC identifiers)

Start:
105,939,299 bp from pter      End:
105,946,500 bp from pter
Size:
7,202 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRIP2_HUMAN, P52943 (See protein sequence)
Recommended Name: Cysteine-rich protein 2  
Size: 208 amino acids; 22493 Da
Subunit: Interacts with TGFB1I1 (By similarity)
1 PDB 3D structure from and Proteopedia for CRIP2:
2CU8 (3D)    
Secondary accessions: A1A4U1 B7Z6C0 E9PD13
Alternative splicing: 2 isoforms:  P52943-1   P52943-2   

Explore the universe of human proteins at neXtProt for CRIP2: NX_P52943

Explore proteomics data for CRIP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257766.1  NP_001257770.1  NP_001303.1  

    ENSEMBL proteins: 
     ENSP00000426119   ENSP00000328521   ENSP00000446875   ENSP00000437723  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P52943

    ProtoNet protein and cluster: P52943

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: CRIP2_HUMAN, P52943
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with CRIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CRIP2:
    cysteine-rich heart protein 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CRIP2           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target CRIP2:
    hsa-mir-335-5p (MIRT019210), hsa-mir-26b-5p (MIRT030299), hsa-mir-1 (MIRT024108)

    Block miRNA regulation of human, mouse, rat CRIP2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005938cell cortex IEA--
    GO:0031012colocalizes with extracellular matrix IDA--

    Find genes that share ontologies with CRIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRIP2
    Interactions:

        GeneGlobe Interaction Network for CRIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CRIP2 (P529432, 3 ENSP000003285214) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLF10Q131182, 3, ENSP000002854074MINT-8259183 I2D: score=2 STRING: ENSP00000285407
    SMN1Q166372, 3MINT-8271014 I2D: score=2 
    SMN2Q166372, 3MINT-8271014 I2D: score=2 
    ATP1B1P050262, 3MINT-8249124 I2D: score=2 
    GADD45GO952572, 3MINT-8256151 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030097hemopoiesis IEA--

    Find genes that share ontologies with CRIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRIP2

    2 Novoseek inferred chemical compound relationships for CRIP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 52.4 14 1407754 (3), 8928791 (3), 8632452 (1), 17526766 (1)
    hydrogen 11.1 1 8632452 (1)



    Find genes that share compounds with CRIP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRIP2 gene (3 alternative transcripts): 
    NM_001270837.1  NM_001270841.1  NM_001312.3  

    Unigene Cluster for CRIP2:

    Cysteine-rich protein 2
    Hs.534309  [show with all ESTs]
    Unigene Representative Sequence: NR_073084
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483017(uc001yrc.2 uc010tyr.1) ENST00000329146(uc001yrd.1)
    ENST00000550577 ENST00000538259 ENST00000551836 ENST00000547643 ENST00000552643
    ENST00000548923 ENST00000548989(uc001yrf.1) ENST00000548309(uc001yrg.2)
    ENST00000551738
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CRIP2
      QuantiFast Probe-based Assays in human, mouse, rat CRIP2

    Additional mRNA sequence: 

    AK057837.1 AK091845.1 AK223251.1 AK300092.1 AK311402.1 AK315757.1 BC000434.2 BC001931.1 
    BC034151.1 BC128101.1 BT019911.1 D42123.1 NR_073081.1 NR_073082.1 NR_073083.1 NR_073084.1 
    NR_073085.1 U36190.1 

    23 DOTS entries:

    DT.450190  DT.100038686  DT.91667257  DT.99960673  DT.100825481  DT.95074182  DT.100825482  DT.91772206 
    DT.100825474  DT.315761  DT.75164058  DT.120732130  DT.91648193  DT.100038685  DT.120732124  DT.95074179 
    DT.100825477  DT.120732147  DT.120732149  DT.91772211  DT.95074168  DT.95074171  DT.95179348 

    Selected AceView cDNA sequences (see all 367):

    CR612651 BE906932 BM983543 BQ004846 BU188919 CA414796 BQ007709 BM993680 
    BF220069 CA424313 BQ889024 BE905458 BG030274 AJ712037 CR591408 CR624241 
    BU857742 D42123 CD107248 AI672394 BQ446892 BM453885 BQ006929 BM008937 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRIP2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:                    -     -     -     -     -     -                 -                                                                           
    SP2:                                            -     -                 -                                                                           
    SP3:                    -     -     -     -     -     -                 -                 -                                                         
    SP4:                    -     -     -     -     -     -     -           -                                                                           
    SP5:        -     -     -     -     -     -     -     -                 -                                                                           


    ECgene alternative splicing isoforms for CRIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGCAG
    CRIP2 Expression
    About this image


    CRIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
    CRIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534309

    UniProtKB/Swiss-Prot: CRIP2_HUMAN, P52943
    Tissue specificity: Widespread tissue expression; highest levels in the heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRIP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crip25 cysteine rich protein 2   --   12 (61.57 cM) 113140236 
    chicken
    (Gallus gallus)
    Aves CRIP26
    cysteine-rich protein 2
    81(a)
    1 ↔ 1
    8(3981797-3985419)
    lizard
    (Anolis carolinensis)
    Reptilia CRIP26
    cysteine-rich protein 2
    82(a)
    1 ↔ 1
    4(74000972-74042406)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.283522 Xenopus laevis transcribed sequence with moderate similarity more 77.27(n)    CB197797.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.56602 Danio rerio mRNA similar to cysteine-rich protein 2 more 79.52(n)    BC044391.1 
    worm
    (Caenorhabditis elegans)
    Secernentea valv-16
    exc-96
    Protein EXC-9 (exc-9) mRNA, complete cds
    58(a)
    58(a)
    many ↔ many
    many ↔ many
    IV(7444634-7445365) WBGene00015216
    IV(7939812-7940850) WBGene00017644


    ENSEMBL Gene Tree for CRIP2 (if available)
    TreeFam Gene Tree for CRIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRIP2 gene
    CSRP22  CSRP12  CRIP32  ENSG000002573412  CRIP12  CSRP32  
    14 SIMAP similar genes for CRIP2 using alignment to 3 protein entries:     CRIP2_HUMAN (see all proteins):
    CRIP1    CRIP3    DKFZp686P2249    NRAP    LASP1    ABLIM1
    MICAL3    TGFB1I1    DKFZp686M148    PDLIM5    CSRP1    PXN
    LIMK1    CSRP3

    Find genes that share paralogs with CRIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRIP2 (see all 191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845744301,2
    --105937989(+) ACTAGC/GTGTCA 2 -- us2k10--------
    rs676799581,2
    C--105938039(+) GCTGT-/CGGCGC 2 -- us2k10--------
    rs128875011,2
    C,F--105938144(+) TCAGAG/CGGCTG 2 -- us2k113Minor allele frequency- C:0.13NA WA CSA EA 377
    rs1877679081,2
    --105938256(+) CCTTCC/TCCAGG 2 -- us2k10--------
    rs1404796151,2
    --105938322(+) ACCCCC/GCAGGG 2 -- us2k10--------
    rs1925567291,2
    --105938448(+) TCCCCA/GGCCAG 2 -- us2k10--------
    rs80086851,2
    C,F,H--105938665(+) TGCTTC/TCTGCA 2 -- us2k116Minor allele frequency- T:0.03NS EA NA WA CSA 794
    rs80076631,2
    C,F,H--105938839(+) TGAGTA/G/TGCAGG 2 -- us2k122NS EA NA WA CSA 1613
    rs80080911,2
    C,F,H--105938882(+) GAAGGC/GACCAG 2 -- us2k117Minor allele frequency- G:0.03NS EA NA WA CSA 798
    rs1180870851,2
    C,F--105938926(+) TGCCCA/GGCCAT 2 -- us2k11Minor allele frequency- G:0.09EA 120

    HapMap Linkage Disequilibrium report for CRIP2 (105939299 - 105946500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRIP2 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749298CNV Deletion23290073
    esv1077360CNV Deletion17803354
    nsv513421CNV Insertion21212237
    nsv1440CNV Insertion18451855
    esv1004211CNV Insertion20482838
    dgv2033n71CNV Loss21882294
    nsv832890CNV Loss17160897
    dgv2025n71CNV Loss21882294
    nsv902490CNV Loss21882294
    dgv2036n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CRIP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601183    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CRIP2:
    Cocaine abuse

    Find genes that share disorders with CRIP2           About GenesLikeMe


    Export disorders for CRIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRIP2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CRIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. (PubMed id 8843343)1, 2, 3 Tsui S.K.W.... Lee C.Y. (Biochem. Mol. Biol. Int. 1996)
    2. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. (PubMed id 8824798)1, 2, 9 Karim M.A....Indo Y. (Genomics 1996)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle. (PubMed id 10681529)1, 3 Huber A....Allescher H.D. (J. Biol. Chem. 2000)
    6. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. (PubMed id 12839623)1, 9 van Ham M....Hendriks W. (amp 2003)
    7. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma. (PubMed id 22154084)1 Lo P.H....Lung M.L. (Cancer Lett. 2012)
    10. Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis. (PubMed id 21540330)1 Cheung A.K....Lung M.L. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1397 HGNC: 2361 AceView: CRIP2 Ensembl:ENSG00000182809 euGenes: HUgn1397
    ECgene: CRIP2 H-InvDB: CRIP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CRIP2 gene:
    Search GeneIP for patents involving CRIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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