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Aliases for CRIP1 Gene

Aliases for CRIP1 Gene

  • Cysteine-Rich Protein 1 (Intestinal) 2 3
  • Cysteine-Rich Intestinal Protein 3 4
  • Cysteine-Rich Heart Protein 3 4
  • CRP-1 3 4
  • CRHP 3 4
  • CRIP 3 4
  • CRP1 3 4
  • HCRHP 4

External Ids for CRIP1 Gene

Previous GeneCards Identifiers for CRIP1 Gene

  • GC22P021804
  • GC14P099944
  • GC14P103925
  • GC14P105024
  • GC14P105952
  • GC14P086151

Summaries for CRIP1 Gene

Entrez Gene Summary for CRIP1 Gene

  • Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIP1 Gene

CRIP1 (Cysteine-Rich Protein 1 (Intestinal)) is a Protein Coding gene. GO annotations related to this gene include peptide binding and AT DNA binding. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot for CRIP1 Gene

  • Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein

Gene Wiki entry for CRIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP1 Gene

Genomics for CRIP1 Gene

Regulatory Elements for CRIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRIP1 Gene

Chromosome:
14
Start:
105,486,317 bp from pter
End:
105,488,947 bp from pter
Size:
2,631 bases
Orientation:
Plus strand

Genomic View for CRIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP1 Gene

Proteins for CRIP1 Gene

  • Protein details for CRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50238-CRIP1_HUMAN
    Recommended name:
    Cysteine-rich protein 1
    Protein Accession:
    P50238
    Secondary Accessions:
    • H3BPI2
    • Q13628
    • Q53XY7
    • Q96J34

    Protein attributes for CRIP1 Gene

    Size:
    77 amino acids
    Molecular mass:
    8533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRIP1 Gene

Proteomics data for CRIP1 Gene at MOPED

Post-translational modifications for CRIP1 Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for CRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CRIP1 Gene

Domains & Families for CRIP1 Gene

Protein Domains for CRIP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50238

UniProtKB/Swiss-Prot:

CRIP1_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with CRIP1: view

No data available for Gene Families for CRIP1 Gene

Function for CRIP1 Gene

Molecular function for CRIP1 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 1,playing a role in processes of cellular repair (located in a region of multiple breakpoint)
UniProtKB/Swiss-Prot Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein

Gene Ontology (GO) - Molecular Function for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003680 AT DNA binding IDA 20108983
GO:0008270 zinc ion binding IDA 9126610
GO:0008301 DNA binding, bending IDA 20108983
GO:0042277 peptide binding IDA 18670594
genes like me logo Genes that share ontologies with CRIP1: view

Phenotypes for CRIP1 Gene

GenomeRNAi human phenotypes for CRIP1:
genes like me logo Genes that share phenotypes with CRIP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP1 Gene

Localization for CRIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIP1 Gene COMPARTMENTS Subcellular localization image for CRIP1 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9126610
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP1 Gene

Pathways & Interactions for CRIP1 Gene

SuperPathways for CRIP1 Gene

No Data Available

Interacting Proteins for CRIP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332449%0d%0a9606.ENSP00000378890%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: P50238-CRIP1_HUMAN ENSP00000332449 for CRIP1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEP 20415737
GO:0007507 heart development TAS 7999070
GO:0008283 cell proliferation TAS 9126610
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 20415737
GO:0010033 response to organic substance IEP 17486081
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for CRIP1 Gene

Drugs & Compounds for CRIP1 Gene

(3) Drugs for CRIP1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
cysteine Nutra 143
histidine Nutra 31
genes like me logo Genes that share compounds with CRIP1: view

Transcripts for CRIP1 Gene

mRNA/cDNA for CRIP1 Gene

Unigene Clusters for CRIP1 Gene

Cysteine-rich protein 1 (intestinal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP1 Gene

No ASD Table

Relevant External Links for CRIP1 Gene

GeneLoc Exon Structure for
CRIP1
ECgene alternative splicing isoforms for
CRIP1

Expression for CRIP1 Gene

mRNA expression in normal human tissues for CRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRIP1 Gene

This gene is overexpressed in Breast (8.1) and Fetal heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIP1 Gene



SOURCE GeneReport for Unigene cluster for CRIP1 Gene Hs.70327

genes like me logo Genes that share expression patterns with CRIP1: view

Protein tissue co-expression partners for CRIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRIP1 Gene

Orthologs for CRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRIP1 35
  • 90.04 (n)
  • 98.7 (a)
CRIP1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CRIP1 35
  • 91.77 (n)
  • 97.4 (a)
-- 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Crip1 35
  • 88.74 (n)
  • 97.4 (a)
Crip1 16
Crip1 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Crip1 35
  • 89.18 (n)
  • 97.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves CRIP1 35
  • 84.85 (n)
  • 90.91 (a)
-- 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia crip1 35
  • 76.62 (n)
  • 84.42 (a)
zebrafish
(Danio rerio)
Actinopterygii crip1 35
  • 78.35 (n)
  • 89.61 (a)
crip1 36
  • 90 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0496.7 37
  • 74 (a)
valv-1 35
  • 66.22 (n)
  • 77.33 (a)
exc-9 36
  • 61 (a)
ManyToMany
valv-1 36
  • 67 (a)
ManyToMany
Species with no ortholog for CRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP1 Gene

ENSEMBL:
Gene Tree for CRIP1 (if available)
TreeFam:
Gene Tree for CRIP1 (if available)

Paralogs for CRIP1 Gene

Paralogs for CRIP1 Gene

Pseudogenes.org Pseudogenes for CRIP1 Gene

genes like me logo Genes that share paralogs with CRIP1: view

Variants for CRIP1 Gene

Sequence variations from dbSNP and Humsavar for CRIP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7140395 -- 105,487,258(+) AGCCG(A/C/G/T)CATGC utr-variant-5-prime
rs7160858 -- 105,487,137(+) GGCGG(G/T)GTCTC intron-variant
rs111607566 -- 105,487,346(+) CGGGG(A/C)GACGA intron-variant
rs758969278 -- 105,487,623(+) AACGC(A/G)GGGCT intron-variant
rs779300887 -- 105,487,470(+) GCGTC(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2036n71 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138

Variation tolerance for CRIP1 Gene

Residual Variation Intolerance Score: 76.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIP1 Gene

HapMap Linkage Disequilibrium report
CRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP1 Gene

Disorders for CRIP1 Gene

Relevant External Links for CRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRIP1
genes like me logo Genes that share disorders with CRIP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP1 Gene

Publications for CRIP1 Gene

  1. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. (PMID: 9480758) Garcia-Barcelo M. … Waye M.M. (Genomics 1998) 2 23 67
  2. Lead does not affect transcription of intestinal zinc-binding proteins in growing rats. (PMID: 17526766) Jamieson J.A. … Taylor C.G. (Exp. Biol. Med. (Maywood) 2007) 23 67
  3. Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve. (PMID: 12451123) Bermingham J.R. … Rosenfeld M.G. (J. Neurosci. 2002) 23 67
  4. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. (PMID: 11078733) Velyvis A. … Qin J. (J. Biol. Chem. 2001) 23 67
  5. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. (PMID: 9507743) DubAc J.Y. … Tremblay R.R. (Arch. Androl. 1998) 23 67

Products for CRIP1 Gene

Sources for CRIP1 Gene

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