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Aliases for CRIP1 Gene

Aliases for CRIP1 Gene

  • Cysteine Rich Protein 1 2 3 5
  • Cysteine-Rich Protein 1 (Intestinal) 2 3
  • Cysteine-Rich Intestinal Protein 3 4
  • Cysteine-Rich Heart Protein 3 4
  • CRP-1 3 4
  • CRP1 3 4
  • CRHP 3 4
  • CRIP 3 4
  • Cysteine-Rich Protein 1 3
  • HCRHP 4

External Ids for CRIP1 Gene

Previous GeneCards Identifiers for CRIP1 Gene

  • GC22P021804
  • GC14P099944
  • GC14P103925
  • GC14P105024
  • GC14P105952
  • GC14P086151

Summaries for CRIP1 Gene

Entrez Gene Summary for CRIP1 Gene

  • Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIP1 Gene

CRIP1 (Cysteine Rich Protein 1) is a Protein Coding gene. GO annotations related to this gene include peptide binding and AT DNA binding. An important paralog of this gene is ENSG00000257341.

UniProtKB/Swiss-Prot for CRIP1 Gene

  • Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Gene Wiki entry for CRIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP1 Gene

Genomics for CRIP1 Gene

Regulatory Elements for CRIP1 Gene

Enhancers for CRIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F105031 1.4 FANTOM5 Ensembl ENCODE 1.5 -452.9 -452911 3.1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ELK1 FOS SP5 GPR132 C14orf79 CRIP1 GC14P105029 GC14P105040
GH14F105074 0.9 FANTOM5 Ensembl ENCODE 1.3 -410.4 -410377 3.7 HDGF TBP CTCF KLF1 KLF17 ZIC2 ZEB1 HIC1 ZFHX2 GLIS2 GPR132 C14orf79 JAG2 NUDT14 LOC102723354 PLD4 CRIP1
GH14F105068 1.1 FANTOM5 ENCODE 1.1 -416.1 -416129 2.9 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 RAD21 ZEB1 ZNF121 GPR132 JAG2 NUDT14 C14orf79 CRIP1 LOC102723354
GH14F105479 1.2 ENCODE 0.8 -0.3 -314 13.2 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 IGHVIII-11-1 IGHVII-33-1 ENSG00000271201 HOMER2P1 IGHV3-42 HOMER2P2 TMEM121 MTA1 ENSG00000257270 C14orf79
GH14F105470 0.2 ENCODE 0.4 -12.0 -12001 8.0 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 YY1 GLIS2 KLF7 KLF13 IGHVIII-11-1 HOMER2P2 IGHVII-33-1 ENSG00000271201 HOMER2P1 IGHV3-42 TMEM121 ENSG00000258811 ENSG00000257270 LOC102723354
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CRIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001792872 1283 2001 HDGF TBP SIN3A DMAP1 RAD21 ZNF48 SP5 GATAD2B MXD3 IKZF1

Genomic Location for CRIP1 Gene

Chromosome:
14
Start:
105,486,317 bp from pter
End:
105,488,947 bp from pter
Size:
2,631 bases
Orientation:
Plus strand

Genomic View for CRIP1 Gene

Genes around CRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP1 Gene

Proteins for CRIP1 Gene

  • Protein details for CRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50238-CRIP1_HUMAN
    Recommended name:
    Cysteine-rich protein 1
    Protein Accession:
    P50238
    Secondary Accessions:
    • H3BPI2
    • Q13628
    • Q53XY7
    • Q96J34

    Protein attributes for CRIP1 Gene

    Size:
    77 amino acids
    Molecular mass:
    8533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRIP1 Gene

Post-translational modifications for CRIP1 Gene

  • Ubiquitination at Lys 9
  • Modification sites at PhosphoSitePlus

Other Protein References for CRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRIP1 Gene

Domains & Families for CRIP1 Gene

Gene Families for CRIP1 Gene

Protein Domains for CRIP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50238

UniProtKB/Swiss-Prot:

CRIP1_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with CRIP1: view

Function for CRIP1 Gene

Molecular function for CRIP1 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 1,playing a role in processes of cellular repair (located in a region of multiple breakpoint)
UniProtKB/Swiss-Prot Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Gene Ontology (GO) - Molecular Function for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003680 AT DNA binding IDA 20108983
GO:0008270 zinc ion binding IDA 9126610
GO:0008301 DNA binding, bending IDA 20108983
GO:0042277 peptide binding IDA 18670594
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP1: view
genes like me logo Genes that share phenotypes with CRIP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP1 Gene

Localization for CRIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIP1 Gene COMPARTMENTS Subcellular localization image for CRIP1 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9126610
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP1 Gene

Pathways & Interactions for CRIP1 Gene

SuperPathways for CRIP1 Gene

No Data Available

Interacting Proteins for CRIP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332449%0d%0a9606.ENSP00000378890%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: P50238-CRIP1_HUMAN ENSP00000332449 for CRIP1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEP 20415737
GO:0007507 heart development TAS 7999070
GO:0008283 cell proliferation TAS 9126610
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 20415737
GO:0010033 response to organic substance IEP 17486081
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for CRIP1 Gene

Drugs & Compounds for CRIP1 Gene

(3) Drugs for CRIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CRIP1: view

Transcripts for CRIP1 Gene

Unigene Clusters for CRIP1 Gene

Cysteine-rich protein 1 (intestinal):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP1 Gene

No ASD Table

Relevant External Links for CRIP1 Gene

GeneLoc Exon Structure for
CRIP1
ECgene alternative splicing isoforms for
CRIP1

Expression for CRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRIP1 Gene

This gene is overexpressed in Breast (8.1) and Fetal heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRIP1 Gene



Protein tissue co-expression partners for CRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRIP1 Gene:

CRIP1

SOURCE GeneReport for Unigene cluster for CRIP1 Gene:

Hs.70327
genes like me logo Genes that share expression patterns with CRIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRIP1 Gene

Orthologs for CRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
OneToMany
CRIP1 34
  • 91.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CRIP1 34 35
  • 90.04 (n)
rat
(Rattus norvegicus)
Mammalia Crip1 34
  • 89.18 (n)
mouse
(Mus musculus)
Mammalia Crip1 34 16 35
  • 88.74 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 91 (a)
OneToMany
CRIP1 34
  • 84.85 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia crip1 34
  • 76.62 (n)
zebrafish
(Danio rerio)
Actinopterygii crip1 34 35
  • 78.35 (n)
worm
(Caenorhabditis elegans)
Secernentea B0496.7 36
  • 74 (a)
valv-1 34 35
  • 66.22 (n)
exc-9 35
  • 61 (a)
ManyToMany
Species where no ortholog for CRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP1 Gene

ENSEMBL:
Gene Tree for CRIP1 (if available)
TreeFam:
Gene Tree for CRIP1 (if available)

Paralogs for CRIP1 Gene

Paralogs for CRIP1 Gene

Pseudogenes.org Pseudogenes for CRIP1 Gene

genes like me logo Genes that share paralogs with CRIP1: view

Variants for CRIP1 Gene

Sequence variations from dbSNP and Humsavar for CRIP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10143851 -- 105,487,998(+) GATGT(C/T)CCCCT intron-variant, upstream-variant-2KB
rs111540735 -- 105,485,388(+) TCCCA(C/T)GATGC upstream-variant-2KB
rs111607566 -- 105,487,346(+) CGGGG(A/C)GACGA intron-variant
rs111624243 -- 105,488,119(+) GTAGG(C/T)GCCGC intron-variant, upstream-variant-2KB
rs112620789 -- 105,485,392(+) ACGAT(A/G)CCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv3987n54 CNV loss 21841781
dgv3996n54 CNV gain 21841781
dgv3998n54 CNV loss 21841781
dgv3999n54 CNV loss 21841781
nsv1054190 CNV gain 25217958
nsv470679 CNV loss 18288195
nsv517055 CNV gain+loss 19592680
nsv566206 CNV loss 21841781
nsv566210 CNV gain 21841781
nsv827088 CNV gain 20364138
nsv952282 CNV deletion 24416366

Variation tolerance for CRIP1 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP1 Gene

Disorders for CRIP1 Gene

Relevant External Links for CRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRIP1

No disorders were found for CRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP1 Gene

Publications for CRIP1 Gene

  1. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. (PMID: 9480758) Garcia-Barcelo M. … Waye M.M. (Genomics 1998) 2 3 22 64
  2. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. (PMID: 9126610) Khoo C. … Cousins R.J. (Protein Expr. Purif. 1997) 3 4 22 64
  3. Isolation and characterization of a cDNA that codes for a LIM- containing protein which is developmentally regulated in heart. (PMID: 7999070) Tsui S.K.W. … Waye M.M.Y. (Biochem. Biophys. Res. Commun. 1994) 3 4 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. (PMID: 9507743) DubAc J.Y. … Tremblay R.R. (Arch. Androl. 1998) 3 22 64

Products for CRIP1 Gene

Sources for CRIP1 Gene

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