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Aliases for CRIP1 Gene

Aliases for CRIP1 Gene

  • Cysteine-Rich Protein 1 (Intestinal) 2 3
  • CRIP 3 4 6
  • Cysteine-Rich Intestinal Protein 3 4
  • Cysteine-Rich Heart Protein 3 4
  • CRP-1 3 4
  • CRHP 3 4
  • CRP1 3 4
  • Cysteine-Rich Protein 1 3
  • HCRHP 4

External Ids for CRIP1 Gene

Previous GeneCards Identifiers for CRIP1 Gene

  • GC22P021804
  • GC14P099944
  • GC14P103925
  • GC14P105024
  • GC14P105952
  • GC14P086151

Summaries for CRIP1 Gene

Entrez Gene Summary for CRIP1 Gene

  • Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIP1 Gene

CRIP1 (Cysteine-Rich Protein 1 (Intestinal)) is a Protein Coding gene. GO annotations related to this gene include DNA binding, bending and AT DNA binding. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot for CRIP1 Gene

  • Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein

Gene Wiki entry for CRIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP1 Gene

Genomics for CRIP1 Gene

Regulatory Elements for CRIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRIP1 Gene

105,486,317 bp from pter
105,488,947 bp from pter
2,631 bases
Plus strand

Genomic View for CRIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP1 Gene

Proteins for CRIP1 Gene

  • Protein details for CRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • H3BPI2
    • Q13628
    • Q53XY7
    • Q96J34

    Protein attributes for CRIP1 Gene

    77 amino acids
    Molecular mass:
    8533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRIP1 Gene

Proteomics data for CRIP1 Gene at MOPED

Post-translational modifications for CRIP1 Gene

  • Ubiquitination at Lys9
  • Modification sites at PhosphoSitePlus

Other Protein References for CRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CRIP1 Gene

Domains for CRIP1 Gene

Protein Domains for CRIP1 Gene


Suggested Antigen Peptide Sequences for CRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LIM zinc-binding domain.
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with CRIP1: view

No data available for Gene Families for CRIP1 Gene

Function for CRIP1 Gene

Molecular function for CRIP1 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 1,playing a role in processes of cellular repair (located in a region of multiple breakpoint)
UniProtKB/Swiss-Prot Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein

Gene Ontology (GO) - Molecular Function for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003680 AT DNA binding IDA 20108983
GO:0008270 zinc ion binding IDA 9126610
GO:0008301 DNA binding, bending IDA 20108983
GO:0042277 peptide binding IDA 18670594
genes like me logo Genes that share ontologies with CRIP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP1 Gene

Localization for CRIP1 Gene

Subcellular locations from

Jensen Localization Image for CRIP1 Gene COMPARTMENTS Subcellular localization image for CRIP1 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20415737
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP1 Gene

Pathways for CRIP1 Gene

SuperPathways for CRIP1 Gene

No Data Available

Interacting Proteins for CRIP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000332449 P50238-CRIP1_HUMAN for CRIP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEP 20415737
GO:0007507 heart development TAS 7999070
GO:0008283 cell proliferation TAS 9126610
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 20415737
GO:0010033 response to organic substance IEP 17486081
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Pathways by source for CRIP1 Gene

Drugs for CRIP1 Gene

(3) Novoseek inferred chemical compound relationships for CRIP1 Gene

Compound -log(P) Hits PubMed IDs
zinc 57.8 8
histidine 41.8 1
cysteine 16.4 2
genes like me logo Genes that share compounds with CRIP1: view

Transcripts for CRIP1 Gene

mRNA/cDNA for CRIP1 Gene

Unigene Clusters for CRIP1 Gene

Cysteine-rich protein 1 (intestinal):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP1 Gene

No ASD Table

Relevant External Links for CRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIP1 Gene

mRNA expression in normal human tissues for CRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CRIP1 Gene

This gene is overexpressed in Breast (8.1) and Fetal heart (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIP1 Gene

SOURCE GeneReport for Unigene cluster for CRIP1 Gene Hs.70327

genes like me logo Genes that share expressions with CRIP1: view

Expression partners for CRIP1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CRIP1 Gene

Orthologs for CRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CRIP1 35
  • 90.04 (n)
  • 98.7 (a)
CRIP1 36
  • 99 (a)
(Canis familiaris)
Mammalia CRIP1 35
  • 91.77 (n)
  • 97.4 (a)
-- 36
  • 96 (a)
(Mus musculus)
Mammalia Crip1 35
  • 88.74 (n)
  • 97.4 (a)
Crip1 16
Crip1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Crip1 35
  • 89.18 (n)
  • 97.4 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
(Gallus gallus)
Aves CRIP1 35
  • 84.85 (n)
  • 90.91 (a)
-- 36
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crip1 35
  • 76.62 (n)
  • 84.42 (a)
(Danio rerio)
Actinopterygii crip1 35
  • 78.35 (n)
  • 89.61 (a)
crip1 36
  • 90 (a)
(Caenorhabditis elegans)
Secernentea B0496.7 37
  • 74 (a)
valv-1 35
  • 66.22 (n)
  • 77.33 (a)
exc-9 36
  • 61 (a)
valv-1 36
  • 67 (a)
Species with no ortholog for CRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP1 Gene

Gene Tree for CRIP1 (if available)
Gene Tree for CRIP1 (if available)

Paralogs for CRIP1 Gene

Paralogs for CRIP1 Gene Pseudogenes for CRIP1 Gene

genes like me logo Genes that share paralogs with CRIP1: view

Variants for CRIP1 Gene

Sequence variations from dbSNP and Humsavar for CRIP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7140395 -- 105,487,258(+) AGCCG(A/C/G/T)CATGC utr-variant-5-prime
rs7160340 -- 105,486,987(+) CATGG(C/T)CCCCT intron-variant
rs7160858 -- 105,487,137(+) GGCGG(G/T)GTCTC intron-variant
rs8012089 -- 105,485,934(+) GGCCC(A/G)GGAGG upstream-variant-2KB
rs12323571 -- 105,486,867(+) CGGCG(C/T)TTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CRIP1 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2036n71 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138

Relevant External Links for CRIP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP1 Gene

Disorders for CRIP1 Gene

No disorders were found for CRIP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CRIP1 Gene

Publications for CRIP1 Gene

  1. Isolation and characterization of a cDNA that codes for a LIM- containing protein which is developmentally regulated in heart. (PMID: 7999070) Tsui S.K.W. … Waye M.M.Y. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  2. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. (PMID: 9480758) Garcia-Barcelo M. … Waye M.M. (Genomics 1998) 2 3 23
  3. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. (PMID: 9126610) Khoo C. … Cousins R.J. (Protein Expr. Purif. 1997) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. (PMID: 9507743) DubAc J.Y. … Tremblay R.R. (Arch. Androl. 1998) 3 23

Products for CRIP1 Gene

Sources for CRIP1 Gene

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