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Aliases for CRIP1 Gene

Aliases for CRIP1 Gene

  • Cysteine Rich Protein 1 2 3 5
  • Cysteine-Rich Protein 1 (Intestinal) 2 3
  • Cysteine-Rich Intestinal Protein 3 4
  • Cysteine-Rich Heart Protein 3 4
  • CRP-1 3 4
  • CRP1 3 4
  • CRHP 3 4
  • CRIP 3 4
  • Cysteine-Rich Protein 1 3
  • HCRHP 4

External Ids for CRIP1 Gene

Previous GeneCards Identifiers for CRIP1 Gene

  • GC22P021804
  • GC14P099944
  • GC14P103925
  • GC14P105024
  • GC14P105952
  • GC14P086151

Summaries for CRIP1 Gene

Entrez Gene Summary for CRIP1 Gene

  • Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CRIP1 Gene

CRIP1 (Cysteine Rich Protein 1) is a Protein Coding gene. GO annotations related to this gene include peptide binding and AT DNA binding. An important paralog of this gene is ENSG00000257341.

UniProtKB/Swiss-Prot for CRIP1 Gene

  • Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Gene Wiki entry for CRIP1 Gene

Additional gene information for CRIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIP1 Gene

Genomics for CRIP1 Gene

Regulatory Elements for CRIP1 Gene

Enhancers for CRIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H105031 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -452.9 -452911 3.1 NFIB SIN3A ZNF76 BMI1 ELK1 ZSCAN5C SCRT2 FOS ETV6 ZEB2 GPR132 CLBA1 CRIP1 GC14P105029 GC14P105040
GH14H105074 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -410.7 -410739 3 TBP HDGF KLF1 BACH1 KLF17 ZIC2 HIC1 ZFHX2 GLIS2 NCOR1 GPR132 CLBA1 JAG2 NUDT14 LINC02298 PLD4 CRIP1
GH14H105068 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.1 -416.1 -416129 2.8 HDGF PKNOX1 TBL1XR1 SIN3A BMI1 BATF ZNF207 FOS ATF7 ETV6 GPR132 JAG2 NUDT14 CLBA1 CRIP1 LINC02298
GH14H105479 1.4 ENCODE dbSUPER 0.7 -0.3 -314 13.2 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF585B MTA1 ENSG00000257270 IGHVIII-11-1 IGHVII-33-1 HOMER2P1 IGHV3-42 HOMER2P2 ENSG00000271201 CDCA4 GPR132
GH14H105470 1.3 ENCODE dbSUPER 0.4 -12.0 -12001 8 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 GLIS2 KLF7 MTA1 IGHVIII-11-1 HOMER2P2 IGHVII-33-1 HOMER2P1 IGHV3-42 ENSG00000271201 ENSG00000257270 BRF1 CLBA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CRIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073830 1283 801 CTCF HDGF DRAP1 SAP130 BACH1 SIN3A DMAP1 EBF1 BCL11B HIC1

Genomic Locations for CRIP1 Gene

Genomic Locations for CRIP1 Gene
2,631 bases
Plus strand

Genomic View for CRIP1 Gene

Genes around CRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIP1 Gene

Proteins for CRIP1 Gene

  • Protein details for CRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • H3BPI2
    • Q13628
    • Q53XY7
    • Q96J34

    Protein attributes for CRIP1 Gene

    77 amino acids
    Molecular mass:
    8533 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRIP1 Gene

Post-translational modifications for CRIP1 Gene

  • Ubiquitination at isoforms=9
  • Modification sites at PhosphoSitePlus

Other Protein References for CRIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRIP1 Gene

Domains & Families for CRIP1 Gene

Gene Families for CRIP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CRIP1 Gene


Suggested Antigen Peptide Sequences for CRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRIP1: view

No data available for UniProtKB/Swiss-Prot for CRIP1 Gene

Function for CRIP1 Gene

Molecular function for CRIP1 Gene

GENATLAS Biochemistry:
cysteine-rich heart protein 1,playing a role in processes of cellular repair (located in a region of multiple breakpoint)
UniProtKB/Swiss-Prot Function:
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

Gene Ontology (GO) - Molecular Function for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003680 AT DNA binding IDA 20108983
GO:0008270 zinc ion binding IDA 9126610
GO:0008301 DNA binding, bending IDA 20108983
GO:0042277 peptide binding IDA 18670594
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CRIP1: view
genes like me logo Genes that share phenotypes with CRIP1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRIP1 Gene

Localization for CRIP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRIP1 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9126610
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRIP1 Gene

Pathways & Interactions for CRIP1 Gene

SuperPathways for CRIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEP 20415737
GO:0007507 heart development TAS 7999070
GO:0008283 cell proliferation TAS 9126610
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 20415737
GO:0010033 response to organic substance IEP 17486081
genes like me logo Genes that share ontologies with CRIP1: view

No data available for Pathways by source and SIGNOR curated interactions for CRIP1 Gene

Drugs & Compounds for CRIP1 Gene

(3) Drugs for CRIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CRIP1: view

Transcripts for CRIP1 Gene

Unigene Clusters for CRIP1 Gene

Cysteine-rich protein 1 (intestinal):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIP1 Gene

No ASD Table

Relevant External Links for CRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CRIP1 Gene

This gene is overexpressed in Breast (8.1) and Fetal heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRIP1 Gene

Protein tissue co-expression partners for CRIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRIP1 Gene:


SOURCE GeneReport for Unigene cluster for CRIP1 Gene:


Evidence on tissue expression from TISSUES for CRIP1 Gene

  • Heart(4.4)
  • Intestine(4.4)
  • Lung(2.3)
  • Skin(2.2)
  • Lymph node(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CRIP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRIP1 Gene

Orthologs for CRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
CRIP1 33
  • 91.77 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
(Bos Taurus)
Mammalia CRIP1 33 34
  • 90.04 (n)
(Rattus norvegicus)
Mammalia Crip1 33
  • 89.18 (n)
(Mus musculus)
Mammalia Crip1 33 16 34
  • 88.74 (n)
(Gallus gallus)
Aves -- 34
  • 91 (a)
CRIP1 33
  • 84.85 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia crip1 33
  • 76.62 (n)
(Danio rerio)
Actinopterygii crip1 33 34
  • 78.35 (n)
(Caenorhabditis elegans)
Secernentea B0496.7 35
  • 74 (a)
valv-1 33 34
  • 66.22 (n)
exc-9 34
  • 61 (a)
Species where no ortholog for CRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIP1 Gene

Gene Tree for CRIP1 (if available)
Gene Tree for CRIP1 (if available)

Paralogs for CRIP1 Gene

Paralogs for CRIP1 Gene Pseudogenes for CRIP1 Gene

genes like me logo Genes that share paralogs with CRIP1: view

Variants for CRIP1 Gene

Sequence variations from dbSNP and Humsavar for CRIP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000295542 -- 105,488,052(+) GGATG(C/T)GGGCT intron-variant, upstream-variant-2KB
rs1000667177 -- 105,487,883(+) CTCGC(C/T)CTCTA intron-variant, upstream-variant-2KB
rs1001031537 -- 105,487,090(+) GAGGT(C/T)CCCAG intron-variant
rs1001472181 -- 105,487,815(+) CCCGG(A/G)GCTGA intron-variant
rs1001839283 -- 105,487,601(+) GGGGA(C/G)CCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRIP1 Gene

Variant ID Type Subtype PubMed ID
nsv952282 CNV deletion 24416366
nsv827088 CNV gain 20364138
nsv566210 CNV gain 21841781
nsv566206 CNV loss 21841781
nsv517055 CNV gain+loss 19592680
nsv470679 CNV loss 18288195
nsv1054190 CNV gain 25217958
dgv3999n54 CNV loss 21841781
dgv3998n54 CNV loss 21841781
dgv3996n54 CNV gain 21841781
dgv3987n54 CNV loss 21841781

Variation tolerance for CRIP1 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIP1 Gene

Disorders for CRIP1 Gene

Relevant External Links for CRIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CRIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRIP1 Gene

Publications for CRIP1 Gene

  1. Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23. (PMID: 9480758) Garcia-Barcelo M … Waye MM (Genomics 1998) 2 3 22 60
  2. Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells. (PMID: 9126610) Khoo C … Cousins RJ (Protein expression and purification 1997) 3 4 22 60
  3. Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart. (PMID: 7999070) Tsui SK … Waye MM (Biochemical and biophysical research communications 1994) 3 4 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate. (PMID: 9507743) Dubé JY … Tremblay RR (Archives of andrology 1998) 3 22 60

Products for CRIP1 Gene

Sources for CRIP1 Gene

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