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Aliases for CRIM1 Gene

Aliases for CRIM1 Gene

  • Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) 2 3
  • Cysteine-Rich Repeat-Containing Protein S52 3 4
  • CRIM-1 3 4
  • S52 3 4
  • Cysteine-Rich Motor Neuron 1 Protein 3
  • Cysteine-Rich Motor Neuron 1 2

External Ids for CRIM1 Gene

Previous HGNC Symbols for CRIM1 Gene

  • S52

Previous GeneCards Identifiers for CRIM1 Gene

  • GC02P036548
  • GC02P036730
  • GC02P036557
  • GC02P036495
  • GC02P036583

Summaries for CRIM1 Gene

Entrez Gene Summary for CRIM1 Gene

  • This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

GeneCards Summary for CRIM1 Gene

CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and insulin-like growth factor-activated receptor activity.

UniProtKB/Swiss-Prot for CRIM1 Gene

  • May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Gene Wiki entry for CRIM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRIM1 Gene

Genomics for CRIM1 Gene

Regulatory Elements for CRIM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRIM1 Gene

Start:
36,355,926 bp from pter
End:
36,551,135 bp from pter
Size:
195,210 bases
Orientation:
Plus strand

Genomic View for CRIM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRIM1 Gene

Proteins for CRIM1 Gene

  • Protein details for CRIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZV1-CRIM1_HUMAN
    Recommended name:
    Cysteine-rich motor neuron 1 protein
    Protein Accession:
    Q9NZV1
    Secondary Accessions:
    • Q2M2G4
    • Q59GH0
    • Q7LCQ5
    • Q9H318

    Protein attributes for CRIM1 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113738 Da
    Quaternary structure:
    • Interacts with BMP4 and BMP7.
    SequenceCaution:
    • Sequence=BAD92376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CRIM1 Gene

Proteomics data for CRIM1 Gene at MOPED

Post-translational modifications for CRIM1 Gene

Other Protein References for CRIM1 Gene

Antibody Products

No data available for DME Specific Peptides for CRIM1 Gene

Domains for CRIM1 Gene

Protein Domains for CRIM1 Gene

Suggested Antigen Peptide Sequences for CRIM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZV1

UniProtKB/Swiss-Prot:

CRIM1_HUMAN :
  • Q9NZV1
Domain:
  • Contains 4 antistasin-like domains.
  • Contains 1 IGFBP N-terminal domain.
  • Contains 6 VWFC domains.
genes like me logo Genes that share domains with CRIM1: view

No data available for Gene Families for CRIM1 Gene

Function for CRIM1 Gene

Molecular function for CRIM1 Gene

UniProtKB/Swiss-Prot Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Gene Ontology (GO) - Molecular Function for CRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005010 insulin-like growth factor-activated receptor activity TAS 10642437
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with CRIM1: view
genes like me logo Genes that share phenotypes with CRIM1: view

Animal Models for CRIM1 Gene

MGI Knock Outs for CRIM1:

Animal Model Products

CRISPR Products

miRNA for CRIM1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRIM1 Gene

Localization for CRIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRIM1 Gene

Processed cysteine-rich motor neuron 1 protein: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRIM1 Gene COMPARTMENTS Subcellular localization image for CRIM1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CRIM1: view

Pathways for CRIM1 Gene

SuperPathways for CRIM1 Gene

No Data Available

Interacting Proteins for CRIM1 Gene

Gene Ontology (GO) - Biological Process for CRIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0007399 nervous system development TAS 10642437
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0048009 insulin-like growth factor receptor signaling pathway TAS 10642437
genes like me logo Genes that share ontologies with CRIM1: view

No data available for Pathways by source for CRIM1 Gene

Transcripts for CRIM1 Gene

Unigene Clusters for CRIM1 Gene

Cysteine rich transmembrane BMP regulator 1 (chordin-like):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRIM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - - - -
SP2:
SP3: - -
SP4: - - - -
SP5:
SP6:

ExUns: 21b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CRIM1 Gene

GeneLoc Exon Structure for
CRIM1
ECgene alternative splicing isoforms for
CRIM1

Expression for CRIM1 Gene

mRNA expression in normal human tissues for CRIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRIM1 Gene

This gene is overexpressed in Artery - Tibial (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRIM1 Gene

SOURCE GeneReport for Unigene cluster for CRIM1 Gene Hs.699247

mRNA Expression by UniProt/SwissProt for CRIM1 Gene

Q9NZV1-CRIM1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
genes like me logo Genes that share expressions with CRIM1: view

In Situ Assay Products

Orthologs for CRIM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRIM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRIM1 35
  • 98.88 (n)
  • 98.83 (a)
CRIM1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRIM1 35
  • 89.31 (n)
  • 88.41 (a)
CRIM1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRIM1 35
  • 91.28 (n)
  • 91.8 (a)
CRIM1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crim1 35
  • 87.81 (n)
  • 89.19 (a)
Crim1 16
Crim1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRIM1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRIM1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crim1 35
  • 87.93 (n)
  • 89.48 (a)
chicken
(Gallus gallus)
Aves CRIM1 35
  • 79.7 (n)
  • 82.84 (a)
CRIM1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRIM1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12291 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488895 35
  • 75.78 (n)
  • 80.14 (a)
zebrafish
(Danio rerio)
Actinopterygii crim1 35
  • 69.54 (n)
  • 71.47 (a)
crim1 36
  • 70 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea crm-1 35
  • 48.25 (n)
  • 40.21 (a)
crm-1 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for CRIM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRIM1 Gene

ENSEMBL:
Gene Tree for CRIM1 (if available)
TreeFam:
Gene Tree for CRIM1 (if available)

Paralogs for CRIM1 Gene

Selected SIMAP similar genes for CRIM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CRIM1: view

No data available for Paralogs for CRIM1 Gene

Variants for CRIM1 Gene

Sequence variations from dbSNP and Humsavar for CRIM1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9295 -- 36,550,682(+) CAAGG(A/G)GCAAT utr-variant-3-prime
rs140715 -- 36,536,359(+) TAGAT(-/ATCT/TATC)GCCTT intron-variant
rs711245 -- 36,541,732(-) GATCA(C/T)GGGCA intron-variant
rs711246 -- 36,541,576(-) GGCGA(C/G)GTGCT intron-variant
rs711247 -- 36,529,145(-) GGACC(A/G)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRIM1 Gene

Variant ID Type Subtype PubMed ID
dgv1170e1 CNV Complex 17122850
nsv2680 CNV Insertion 18451855
nsv833803 CNV Gain 17160897
dgv1171e1 CNV Complex 17122850
esv2536024 CNV Deletion 19546169
esv2719922 CNV Deletion 23290073
esv1790942 CNV Deletion 17803354
nsv213151 CNV Loss 16902084
esv2664333 CNV Deletion 23128226

Relevant External Links for CRIM1 Gene

HapMap Linkage Disequilibrium report
CRIM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRIM1 Gene

Disorders for CRIM1 Gene

(1) University of Copenhagen DISEASES for CRIM1 Gene

Relevant External Links for CRIM1

Genetic Association Database (GAD)
CRIM1
Human Genome Epidemiology (HuGE) Navigator
CRIM1
genes like me logo Genes that share disorders with CRIM1: view

No data available for UniProtKB/Swiss-Prot for CRIM1 Gene

Publications for CRIM1 Gene

  1. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. (PMID: 12805376) Wilkinson L. … Little M.H. (J. Biol. Chem. 2003) 3 4 23
  2. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. (PMID: 10642437) Kolle G.V. … Yamada T. (Mech. Dev. 2000) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CRIM1 Gene

Sources for CRIM1 Gene

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