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CRIM1 Gene

protein-coding   GIFtS: 56
GCID: GC02P036583

Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)

(Previous name: cysteine-rich motor neuron 1)
(Previous symbol: S52)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)1 2
S521 2 3
Cysteine-Rich Repeat-Containing Protein S522 3
CRIM-12 3
Cysteine-Rich Motor Neuron 11
Cysteine-Rich Motor Neuron 1 Protein2

External Ids:    HGNC: 23591   Entrez Gene: 512322   Ensembl: ENSG000001509387   OMIM: 6061895   UniProtKB: Q9NZV13   

Export aliases for CRIM1 gene to outside databases

Previous GC identifers: GC02P036548 GC02P036730 GC02P036557 GC02P036495 GC02P036324


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRIM1 Gene:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth
factor-binding domain. The encoded protein may play a role in tissue development though interactions with members
of the transforming growth factor beta family, such as bone morphogenetic proteins. (provided by RefSeq, Nov
2010)

GeneCards Summary for CRIM1 Gene:
CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like)) is a protein-coding gene. Diseases associated with CRIM1 include syndactyly, and neuronitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and insulin-like growth factor-activated receptor activity.

UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron
differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis.
Modulates BMP activity by affecting its processing and delivery to the cell surface

Gene Wiki entry for CRIM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CRIM1 gene promoter:
         AP-1   Brachyury   ATF-2   FOXL1   GATA-1   S8   c-Rel   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRIM1 promoter sequence
   Search Chromatin IP Primers for CRIM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRIM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p21

CRIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRIM1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P036583:  view genomic region     (about GC identifiers)

Start:
36,583,069 bp from pter      End:
36,778,278 bp from pter
Size:
195,210 bases      Orientation:
plus strand

1 alternative location:
Chr2-,NW_003315908 6,693-7,089     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1 (See protein sequence)
Recommended Name: Cysteine-rich motor neuron 1 protein precursor  
Size: 1036 amino acids; 113738 Da
Subunit: Interacts with BMP4 and BMP7
Sequence caution: Sequence=BAD92376.1; Type=Erroneous initiation;
Secondary accessions: Q2M2G4 Q59GH0 Q7LCQ5 Q9H318

Explore the universe of human proteins at neXtProt for CRIM1: NX_Q9NZV1

Explore proteomics data for CRIM1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys978
  • Glycosylation2 at Asn71, Asn113, Asn330, Asn474, Ser596, Ser598, Asn746
  • Modification sites at PhosphoSitePlus

  • See CRIM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057525.1  
    ENSEMBL proteins: 
     ENSP00000280527   ENSP00000407636   ENSP00000415706   ENSP00000403120  

    CRIM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CRIM1

    CRIM1 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CRIM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011061 Hirudin/antistatin
     IPR000867 IGFBP-like
     IPR009030 Growth_fac_rcpt_N_dom
     IPR004094 Antistasin-like
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q9NZV1

    ProtoNet protein and cluster: Q9NZV1

    UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
    Similarity: Contains 4 antistasin-like domains
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 6 VWFC domains


    CRIM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRIM1_HUMAN, Q9NZV1
    Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron
    differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis.
    Modulates BMP activity by affecting its processing and delivery to the cell surface

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005010insulin-like growth factor-activated receptor activity TAS10642437
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
         
    CRIM1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Crim1):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  normal 
     other  renal/urinary system  vision/eye 

    CRIM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crim1tm1.1Dpen for CRIM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRIM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRIM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRIM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRIM1

    miRNA
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    miRTarBase miRNAs that target CRIM1:
    hsa-mir-26b-5p (MIRT030160), hsa-mir-455-3p (MIRT037869), hsa-mir-375 (MIRT020040), hsa-mir-92b-3p (MIRT040735), hsa-mir-20b-5p (MIRT004053)

    Block miRNA regulation of human, mouse, rat CRIM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRIM1 (see all 91):
    hsa-miR-520e hsa-miR-106a hsa-miR-199a-3p hsa-miR-4272 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCRIM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRIM1
    Predesigned siRNA for gene silencing in human, mouse, rat CRIM1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CRIM1

    Clone
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    OriGene clones in human, mouse for CRIM1 (see all 6)
    OriGene ORF clones in mouse, rat for CRIM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRIM1 (NM_016441)
    Sino Biological Human cDNA Clone for CRIM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRIM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRIM1_HUMAN, Q9NZV1: Processed cysteine-rich motor neuron 1 protein: Secreted
    CRIM1_HUMAN, Q9NZV1: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    CRIM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRIM1
    Interactions:

        Search GeneGlobe Interaction Network for CRIM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRIM1 (Q9NZV13 ENSP000002805274) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997593I2D: score=2 
    PAK1Q131533I2D: score=2 
    TGFBR1P368973I2D: score=2 
    ATXN7O152653I2D: score=1 
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007399nervous system development TAS10642437
    GO:0048009insulin-like growth factor receptor signaling pathway TAS10642437

    CRIM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRIM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRIM1 gene: 
    NM_016441.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280527(uc002rpd.3) ENST00000426856 ENST00000428774 ENST00000473403
    ENST00000477491 ENST00000497236 ENST00000481321 ENST00000413985
    miRNA
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    Block miRNA regulation of human, mouse, rat CRIM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRIM1 (see all 91):
    hsa-miR-520e hsa-miR-106a hsa-miR-199a-3p hsa-miR-4272 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCRIM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CRIM1
    Predesigned siRNA for gene silencing in human, mouse, rat CRIM1
    Clone
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    OriGene clones in human, mouse for CRIM1 (see all 6)
    OriGene ORF clones in mouse, rat for CRIM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRIM1 (NM_016441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRIM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1
    Primer
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    OriGene qPCR primer pairs and template standards for CRIM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRIM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRIM1
      QuantiTect SYBR Green Assays in human, mouse, rat CRIM1
      QuantiFast Probe-based Assays in human, mouse, rat CRIM1

    Selected AceView cDNA sequences (see all 265):

    AY358371 AI263715 AA573989 BU737990 BE311675 AI651806 BM701349 AI860899 
    AA953328 CN484021 AI090957 AF167706 BU624577 CD679098 BM696553 NM_016441 
    BM760932 BP337235 BQ007661 CA446386 AI524480 AI471757 BF593640 AI050757 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRIM1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:              -     -     -                                                     -                                               -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -     -                     
    SP4:              -     -     -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 21b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CRIM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRIM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATATTAT
    CRIM1 Expression
    About this image


    CRIM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Lens
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Epithelial Cells
             Podocytes Podocyte Layer
    CRIM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRIM1 Protein Expression

    UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
    Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver
    and small intestine. Expressed in blood vessels (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat CRIM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRIM1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crim11 , 5 cysteine rich transmembrane BMP regulator 1 (chordin more1, 5 87.81(n)1
    89.19(a)1
      17 (48.09 cM)5
    507661  NM_015800.31  NP_056615.11 
     782002485 
    chicken
    (Gallus gallus)
    Aves CRIM11 cysteine rich transmembrane BMP regulator 1 (chordin-like) 79.7(n)
    82.84(a)
      395067  NM_204425.1  NP_989756.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRIM16
    cysteine rich transmembrane BMP regulator 1 (chord...
    76(a)
    1 ↔ 1
    1(233000774-233161060)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.122912 Xenopus laevis transcribed sequence with moderate similarity more 76.3(n)    BJ084586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crim11 cysteine rich transmembrane BMP regulator 1 (chordin more 69.54(n)
    71.47(a)
      404210  NM_212821.1  NP_997986.1 
    worm
    (Caenorhabditis elegans)
    Secernentea crm-11 crm-1 48.25(n)
    40.21(a)
      179439  NM_171529.4  NP_741616.2 


    ENSEMBL Gene Tree for CRIM1 (if available)
    TreeFam Gene Tree for CRIM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRIM1 gene
    1 SIMAP similar gene for CRIM1 using alignment to 7 protein entries:     CRIM1_HUMAN (see all proteins):
    ESM1

    CRIM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRIM1 (see all 4613)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419278471,2
    --36322079(+) AATCAA/GTGATA 1 -- int10--------
    rs1843300591,2
    --36581389(+) TGGGGA/GAATAG 1 -- us2k10--------
    rs727851571,2
    C,F--36584754(+) TTATTT/CTGATG 1 -- int14Minor allele frequency- C:0.12NA EA 244
    rs560617681,2
    C--36585267(+) TAAGAC/TATTGG 1 -- int10--------
    rs1997939571,2
    --36585270(+) ACATT-/GGGGTT 1 -- int10--------
    rs1117871501,2
    C--36585271(+) CATTG-/A/TGGTTA 1 -- int11CSA 2
    rs621346191,2
    C--36585272(+) CATTGG/AGTTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs677443981,2
    C--36585272(+) CATTGG/AAGTTAG 1 -- int11Minor allele frequency- AA:0.50NA 2
    rs747051051,2
    C--36585272(+) ATTGG-/AGTTAG 1 -- int10--------
    rs37709681,2
    C,F,H--36585324(-) GGGGAC/TAATAC 1 -- int125Minor allele frequency- T:0.19EA NS NA WA CSA 3908

    HapMap Linkage Disequilibrium report for CRIM1 (36583069 - 36778278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CRIM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2536024CNV Deletion19546169
    esv1790942CNV Deletion17803354
    esv2719922CNV Deletion23290073
    esv2664333CNV Deletion23128226
    nsv2680CNV Insertion18451855
    nsv213151CNV Loss16902084
    nsv833803CNV Gain17160897
    dgv1171e1CNV Complex17122850
    dgv1170e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606189    OMIM disorders: --

    7 diseases for CRIM1:    
    About MalaCards
    syndactyly    neuronitis    ataxia    myeloid leukemia
    leukemia    endotheliitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for CRIM1:
    Syndactyly

    CRIM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRIM1
    Human Genome Epidemiology (HuGE) Navigator: CRIM1 (2 documents)

    Export disorders for CRIM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRIM1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CRIM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. (PubMed id 10642437)1, 2, 3 Kolle G.V.... Yamada T. (Mech. Dev. 2000)
    2. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. (PubMed id 12805376)1, 2, 9 Wilkinson L.... Little M.H. (J. Biol. Chem. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    5. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (Croat. Med. J. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. (PubMed id 12464430)1, 2 Glienke J.... Thierauch K.-H. (Mech. Dev. 2002)
    10. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PubMed id 23967269)1 Kim J.H....Shin H.D. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51232 HGNC: 2359 AceView: CRIM1 Ensembl:ENSG00000150938 euGenes: HUgn51232
    ECgene: CRIM1 H-InvDB: CRIM1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRIM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRIM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRIM1 gene:
    Search GeneIP for patents involving CRIM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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