Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRIM1 Gene

protein-coding   GIFtS: 59
GCID: GC02P036495

Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)

(Previous name: cysteine-rich motor neuron 1)
(Previous symbol: S52)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like)1 2
S521 2 3
Cysteine-Rich Repeat-Containing Protein S522 3
CRIM-12 3
Cysteine-Rich Motor Neuron 11
Cysteine-Rich Motor Neuron 1 Protein2

External Ids:    HGNC: 23591   Entrez Gene: 512322   Ensembl: ENSG000001509387   OMIM: 6061895   UniProtKB: Q9NZV13   

Export aliases for CRIM1 gene to outside databases

Previous GC identifers: GC02P036548 GC02P036730 GC02P036557 GC02P036324


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRIM1 Gene:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth
factor-binding domain. The encoded protein may play a role in tissue development though interactions with members
of the transforming growth factor beta family, such as bone morphogenetic proteins. (provided by RefSeq, Nov
2010)

GeneCards Summary for CRIM1 Gene: 
CRIM1 (cysteine rich transmembrane BMP regulator 1 (chordin-like)) is a protein-coding gene. Diseases associated with CRIM1 include syndactyly, and neuronitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and insulin-like growth factor-activated receptor activity.

UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron
differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis.
Modulates BMP activity by affecting its processing and delivery to the cell surface

Gene Wiki entry for CRIM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRIM1 gene promoter:
         AP-1   Brachyury   ATF-2   FOXL1   GATA-1   S8   c-Rel   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRIM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRIM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p21

CRIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRIM1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P036495:  view genomic region     (about GC identifiers)

Start:
36,583,069 bp from pter      End:
36,778,278 bp from pter
Size:
195,210 bases      Orientation:
plus strand

1 alternative location:
Chr2-,NW_003315908 6,693-7,089     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1 (See protein sequence)
Recommended Name: Cysteine-rich motor neuron 1 protein precursor  
Size: 1036 amino acids; 113738 Da
Subunit: Interacts with BMP4 and BMP7
Subcellular location: Processed cysteine-rich motor neuron 1 protein: Secreted
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAD92376.1; Type=Erroneous initiation;
Secondary accessions: Q2M2G4 Q59GH0 Q7LCQ5 Q9H318

Explore the universe of human proteins at neXtProt for CRIM1: NX_Q9NZV1

Explore proteomics data for CRIM1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZV1

  • CRIM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRIM1 Protein Expression
    REFSEQ proteins: NP_057525.1  
    ENSEMBL proteins: 
     ENSP00000280527   ENSP00000407636   ENSP00000415706   ENSP00000403120  

    Human Recombinant Protein Products for CRIM1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CRIM1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CRIM1
    GenScript Custom Purified and Recombinant Proteins Services for CRIM1
    Novus Biologicals CRIM1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRIM1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CRIM1 for ontologies           About GeneDecksing



    CRIM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRIM1
    R&D Systems Antibodies for CRIM1
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRIM1
    GenScript Custom Superior Antibodies Services for CRIM1
    Novus Biologicals CRIM1 Antibodies
    Abcam antibodies for CRIM1
    Cloud-Clone Corp. Antibodies for CRIM1 
    ThermoFisher Antibodies for CRIM1
    LSBio Antibodies in human, mouse, rat for CRIM1 

    Assay Products for CRIM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRIM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRIM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRIM1 
    Cloud-Clone Corp. CLIAs for CRIM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011061 Prot_inh_I14/15_hirudin/antisn
     IPR000867 IGFBP-like
     IPR018112 Prot_inh_I15_antistasin
     IPR004094 Prot_inh_I15_antistasin-like
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q9NZV1

    ProtoNet protein and cluster: Q9NZV1

    UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
    Similarity: Contains 4 antistasin-like domains
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 6 VWFC domains


    CRIM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRIM1_HUMAN, Q9NZV1
    Function: May play a role in CNS development by interacting with growth factors implicated in motor neuron
    differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis.
    Modulates BMP activity by affecting its processing and delivery to the cell surface

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ----
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0005010insulin-like growth factor-activated receptor activity TAS10642437
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
         
    CRIM1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Crim1):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  normal 
     other  renal/urinary system  vision/eye 

    CRIM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crim1tm1.1Dpen for CRIM1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRIM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRIM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRIM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRIM1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRIM1:
    hsa-mir-20b (MIRT004053)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRIM1
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate CRIM1 (see all 91):
    hsa-miR-520e hsa-miR-106a hsa-miR-199a-3p hsa-miR-4272 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCRIM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRIM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRIM1
    Sirion Biotech Customized adenovirus for overexpression of CRIM1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CRIM1 (see all 5)
    OriGene ORF clones in mouse, rat for CRIM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRIM1 (NM_016441)
    Sino Biological Human cDNA Clone for CRIM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRIM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1
    Sirion Biotech Customized lentivirus for stable overexpression of CRIM1 
                         Customized lentivirus expression plasmids for stable overexpression of CRIM1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRIM1
    Search LifeMap BioReagents cell lines for CRIM1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRIM1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for CRIM1 (Q9NZV13 ENSP000002805274) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997593I2D: score=2 
    PAK1Q131533I2D: score=2 
    TGFBR1P368973I2D: score=2 
    ATXN7O152653I2D: score=1 
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0007399nervous system development TAS10642437
    GO:0048009insulin-like growth factor receptor signaling pathway TAS10642437

    CRIM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRIM1

    Search CenterWatch for drugs/clinical trials and news about CRIM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRIM1 gene: 
    NM_016441.2  

    Unigene Cluster for CRIM1:

    Cysteine rich transmembrane BMP regulator 1 (chordin-like)
    Hs.699247  [show with all ESTs]
    Unigene Representative Sequence: NM_016441
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280527(uc002rpd.3) ENST00000426856 ENST00000428774 ENST00000473403
    ENST00000477491 ENST00000497236 ENST00000481321 ENST00000413985
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRIM1
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate CRIM1 (see all 91):
    hsa-miR-520e hsa-miR-106a hsa-miR-199a-3p hsa-miR-4272 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidCRIM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRIM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIM1
    Clone
    Products:
         
    OriGene clones in human, mouse for CRIM1 (see all 5)
    OriGene ORF clones in mouse, rat for CRIM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRIM1 (NM_016441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRIM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1
    Sirion Biotech Customized lentivirus for stable overexpression of CRIM1 
                         Customized lentivirus expression plasmids for stable overexpression of CRIM1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRIM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRIM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRIM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIM1

    Additional mRNA sequence: 

    AB209139.1 AF167706.1 AK026159.1 AK300817.1 AY358371.1 BC026227.1 BC111989.1 BC113371.1 
    BX648755.1 CR627451.1 

    16 DOTS entries:

    DT.451999  DT.91662291  DT.99995172  DT.91992969  DT.120959978  DT.92444898  DT.120959938  DT.40108927 
    DT.92444900  DT.100827982  DT.120959858  DT.91896861  DT.92026091  DT.95171014  DT.40205096  DT.95287406 

    24/265 AceView cDNA sequences (see all 265):

    AL703026 CN484021 AA573989 BU624577 CB267915 BF593640 CA446386 AI471757 
    BE311675 AI263715 AI860899 CD679098 BM767178 BP337235 AF167706 BU737990 
    BQ007661 AI651806 BQ721252 AI392958 AI050757 AA953328 AY358371 BE740185 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CRIM1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:              -     -     -                                                     -                                               -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -     -                     
    SP4:              -     -     -     -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 21b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CRIM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRIM1 expression in normal human tissues (normalized intensities)      CRIM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATATTAT
    CRIM1 Expression
    About this image


    CRIM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Neural Tube (Nervous System)
             Diencephalon

    See CRIM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRIM1

    SOURCE GeneReport for Unigene cluster: Hs.699247

    UniProtKB/Swiss-Prot: CRIM1_HUMAN, Q9NZV1
    Tissue specificity: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver
    and small intestine. Expressed in blood vessels (at protein level)

        SABiosciences Custom PCR Arrays for CRIM1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRIM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CRIM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRIM1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRIM1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crim11 , 5 cysteine rich transmembrane BMP regulator 1 (chordin more1, 5 87.81(n)1
    89.19(a)1
      17 (48.09 cM)5
    507661  NM_015800.31  NP_056615.11 
     782002485 
    chicken
    (Gallus gallus)
    Aves CRIM11 cysteine rich transmembrane BMP regulator 1 (chordin-like) 79.45(n)
    82.33(a)
      395067  NM_204425.1  NP_989756.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRIM16
    Uncharacterized protein
    76(a)
    1 ↔ 1
    1(233000774-233161060)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.122912 Xenopus laevis transcribed sequence with moderate similarity more 76.3(n)    BJ084586.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crim11 cysteine rich transmembrane BMP regulator 1 (chordin more 69.31(n)
    71.16(a)
      404210  NM_212821.1  NP_997986.1 
    worm
    (Caenorhabditis elegans)
    Secernentea crm-11 Protein CRM-1 47.66(n)
    39.08(a)
      179439  NM_171529.3  NP_741616.2 


    ENSEMBL Gene Tree for CRIM1 (if available)
    TreeFam Gene Tree for CRIM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRIM1 gene
    1 SIMAP similar gene for CRIM1 using alignment to 7 protein entries:     CRIM1_HUMAN (see all proteins):
    ESM1

    CRIM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4613 SNPs in CRIM1 are shown (see all 4613)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419278471,2
    --36322079(+) AATCAA/GTGATA 1 -- int10--------
    rs1843300591,2
    --36581389(+) TGGGGA/GAATAG 1 -- us2k10--------
    rs727851571,2
    C,F--36584754(+) TTATTT/CTGATG 1 -- int14Minor allele frequency- C:0.12NA EA 244
    rs560617681,2
    C--36585267(+) TAAGAC/TATTGG 1 -- int10--------
    rs1997939571,2
    --36585270(+) ACATT-/GGGGTT 1 -- int10--------
    rs1117871501,2
    C--36585271(+) CATTG-/A/TGGTTA 1 -- int11CSA 2
    rs621346191,2
    C--36585272(+) CATTGG/AGTTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs677443981,2
    C--36585272(+) CATTGG/AAGTTAG 1 -- int11Minor allele frequency- AA:0.50NA 2
    rs747051051,2
    C--36585272(+) ATTGG-/AGTTAG 1 -- int10--------
    rs37709681,2
    C,F,H--36585324(-) GGGGAC/TAATAC 1 -- int125Minor allele frequency- T:0.19EA NS NA WA CSA 3908

    HapMap Linkage Disequilibrium report for CRIM1 (36583069 - 36778278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CRIM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2536024CNV Deletion19546169
    esv1790942CNV Deletion17803354
    esv2719922CNV Deletion23290073
    esv2664333CNV Deletion23128226
    nsv2680CNV Insertion18451855
    nsv213151CNV Loss16902084
    nsv833803CNV Gain17160897
    dgv1171e1CNV Complex17122850
    dgv1170e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CRIM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRIM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606189    OMIM disorders: --

    7 diseases for CRIM1:    About MalaCards
    syndactyly    neuronitis    macular degeneration    ataxia
    myeloid leukemia    leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CRIM1:
    Syndactyly

    CRIM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRIM1
    Human Genome Epidemiology (HuGE) Navigator: CRIM1 (2 documents)

    Export disorders for CRIM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRIM1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with CRIM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. (PubMed id 10642437)1, 2, 3 Kolle G.V.... Yamada T. (2000)
    2. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. (PubMed id 12805376)1, 2, 9 Wilkinson L.... Little M.H. (2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (2010)
    5. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. (PubMed id 19260139)1, 4 Polasek O....Rudan I. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. (PubMed id 12464430)1, 2 Glienke J.... Thierauch K.-H. (2002)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51232 HGNC: 2359 AceView: CRIM1 Ensembl:ENSG00000150938 euGenes: HUgn51232
    ECgene: CRIM1 H-InvDB: CRIM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRIM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CRIM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRIM1 gene:
    Search GeneIP for patents involving CRIM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CRIM1
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CRIM1 (CRIM1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CRIM1 (CRIM1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CRIM1  
     OriGene qPCR primer pairs and template standards for CRIM1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CRIM1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRIM1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CRIM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRIM1   OriGene Custom Protein Services for CRIM1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRIM1
     QIAGEN SeqTarget long-range PCR primers for resequencing CRIM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIM1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIM1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIM1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIM1
     GenScript Custom Purified and Recombinant Proteins Services for CRIM1 GenScript cDNA clones with any tag delivered in your preferred vector for CRIM1
     GenScript Custom Assay Services for CRIM1 GenScript Custom Superior Antibodies Services for CRIM1
     GenScript Custom overexpressing Cell Line Services for CRIM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CRIM1 promoter
     Search Chromatin IP Primers for CRIM1
     RT2 qPCR Primer Assay in human, mouse, rat CRIM1
     Search GNC Networks for CRIM1
     SABiosciences Custom PCR Arrays for CRIM1
     Search Tocris compounds for CRIM1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CRIM1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CRIM1 antibodies
     CRIM1 proteins
     Antibodies for CRIM1
     See all of Abcam's Antibodies, Kits and Proteins for CRIM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CRIM1
     Antibodies for CRIM1
     ELISAs for CRIM1
     CLIAs for CRIM1
     Search LifeMap BioReagents cell lines for CRIM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1
     SwitchGear 3'UTR luciferase reporter plasmids for CRIM1
     SwitchGear Promoter luciferase reporter plasmids for CRIM1
     ThermoFisher Antibodies for CRIM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CRIM1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRIM1
    Customized:
     lentivirus for stable overexpression of CRIM1
     lentivirus expression plasmids for stable overexpression of CRIM1
     adenovirus for overexpression of CRIM1
     LSBio Antibodies in human, mouse, rat for CRIM1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRIM1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4