CRIM1 Gene

Aliases
for CRIM1 gene

Previous GC identifers: GC02P036548 GC02P036730 GC02P036557 GC02P036324

Summaries
for CRIM1 gene

Genomic Views
for CRIM1 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022184.15  

SwitchGear Promoter luciferase reporter plasmid: CRIM1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRIM1

CRIM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P036495:  view genomic region     (about GC identifiers)

Proteins
for CRIM1 gene

Explore the universe of human proteins at neXtProt for CRIM1: NX_Q9NZV1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CRIM1
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CRIM1
	GenScript Custom Purified and Recombinant Proteins Services for CRIM1
	Novus Biologicals CRIM1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRIM1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CRIM1
	R&D Systems Antibodies for CRIM1
	Browse OriGene Antibodies OriGene Custom Antibody Services for CRIM1
	GenScript Custom Superior Antibodies Services for CRIM1
	Novus Biologicals CRIM1 Antibodies
	Search for Antibodies for CRIM1 at Abcam
	Uscn Antibodies for CRIM1
	Search ThermoFisher Antibodies for CRIM1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRIM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRIM1

Protein Domains /
Families
for CRIM1 gene

ProtoNet protein and cluster: Q9NZV1

Function
for CRIM1 gene

miRNA Products:		miRTarBase miRNAs that target CRIM1: hsa-mir-20b (MIRT004053)
		OriGene 3'-UTR Clone: CRIM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRIM1
		8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate CRIM1 (see all 91):
		hsa-miR-520e hsa-miR-106a hsa-miR-199a-3p hsa-miR-4272 hsa-miR-15a hsa-miR-218-1* hsa-miR-374a hsa-miR-3138
		SwitchGear 3'UTR luciferase reporter plasmid: CRIM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRIM1 (see all 4) OriGene shRNA RFP: CRIM1 OriGene siRNA: CRIM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRIM1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CRIM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRIM1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRIM1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CRIM1 (NM_016441)
		Sino Biological Human cDNA Clone for CRIM1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRIM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRIM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRIM1
		Search LifeMap BioReagents cell lines for CRIM1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Crim1)

Pathways & Interactions
for CRIM1 gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CRIM1 gene

Transcripts
for CRIM1 gene

Expression
for CRIM1 gene

CRIM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCATATTAT

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyPodocyte LayerPodocytes			Kidney
	EyeLens			Eye
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRIM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRIM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRIM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRIM1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRIM1

Orthologs
for CRIM1 gene

Paralogs
for CRIM1 gene

Paralogs for CRIM1 gene

CHRD²  CHRDL1²  VWCE²  CHRDL2²  

1 SIMAP similar gene for CRIM1 using alignment to 7 protein entries:     CRIM1_HUMAN (see all proteins):

NELL1

CRIM1 for paralogs           About GeneDecksing

Genomic Variants
for CRIM1 gene

10/3958 NCBI SNPs in CRIM1 are shown (see all 3958)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1843300591,2		--	36581389(+)	TGGGGA/GAATAG	1	--	us2k1		0	--	--	--	--
rs67085451,2	C,F,H,	--	36581467(+)	AGTATA/GAATTT	2	--	int1 us2k1		13		NA WA CSA EA	376
rs1506731001,2		--	36581481(+)	CCACAA/CACATA	2	--	us2k1 int1		0	--	--	--	--
rs1384315141,2		--	36581721(+)	ACCCAC/TCTTGT	2	--	us2k1 int1		0	--	--	--	--
rs763361601,2	F,	--	36581729(+)	TGTGAA/CTGGTA	2	--	int1 us2k1		2		WA EA	238
rs1891797991,2		--	36581856(+)	ACTTCC/TGTTGC	2	--	int1 us2k1		0	--	--	--	--
rs1492806141,2		--	36581988(+)	ATGTCA/GTATGG	2	--	us2k1 nc-transcript-variant		0	--	--	--	--
rs1822186711,2		--	36582074(+)	AGGGAG/TAAAGA	2	--	nc-transcript-variantus2k1		0	--	--	--	--
rs1473498151,2		--	36582113(+)	CTCCCA/GTAACA	2	--	nc-transcript-variantus2k1		0	--	--	--	--
rs1865564941,2		--	36582127(+)	CACCTC/TGGCAC	2	--	us2k1 int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRIM1 (36583069 - 36778278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CRIM1
     4 CNVs: 3351 97818 2378 4281
     2 Indels: 12066 26678

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRIM1

DNA2.0 Custom Variant and Variant Library Synthesis for CRIM1

Disorders / Diseases
for CRIM1 gene

Publications
for CRIM1 gene

PubMed articles for CRIM1 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with CRIM1)

Utopia: connect your pdf to the dynamic world of online information

1. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. (PubMed id 10642437)^{1, 2, 3} Kolle G.V.... Yamada T. (2000)
2. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. (PubMed id 12805376)^{1, 2, 9} Wilkinson L.... Little M.H. (2003)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo. (PubMed id 12464430)^{1, 2} Glienke J.... Thierauch K.-H. (2002)
7. Invertebrate hematopoiesis: an astakine-dependent nov el hematopoietic factor. (PubMed id 21220699)¹ Lin X....SAPderhAoll I. (2011)
8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
9. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
10. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)

External Searches for CRIM1 gene

Genome Databases showing CRIM1 gene

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Specialized Databases showing CRIM1 gene

Products
for CRIM1 gene