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CRHR2 Gene

protein-coding GIFtS: 66

GC07M030658

corticotropin releasing hormone receptor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CRF2 ^³
CRF2R ^³
CRFR2 ^², ⁵
CRH2R ^³
OTTHUMP00000024836 ^²

Descriptions
CRF-R 2 ^³
CRH-R 2 ^³
Corticotropin-releasing hormone receptor 2 ^³
corticotropin releasing hormone receptor 2 ^²

External Ids
HGNC: 2358¹
Entrez Gene: 1395²
UniProtKB: Q13324³
Ensembl: ENSG00000106113⁷

Search outside databases for aliases for CRHR2 gene

Previous GC identifers: GC07M030334 GC07M030434 GC07M030465

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324

Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding.

Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins

which activate adenylyl cyclase

Gene Wiki entry for CRHR2 (Corticotropin_releasing_hormone_receptor_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRHR2 gene

Entrez Gene cytogenetic band: 7p15.1 Ensembl cytogenetic band: 7p15.1 HGNC cytogenetic band: 7p21-p15

CRHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M030658: (about GC identifiers)

Start:	30,659,388 bp from pter
End:	30,706,244 bp from pter
Size:	46,857 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 30,742,515-30,771,785

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324 (See protein sequence)

Recommended Name: Corticotropin-releasing factor receptor 2 precursor

Size: 411 amino acids; 47688 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: O43461 Q4QRJ4 Q99431

Alternative splicing: 3 isoforms: Q13324-1 Q13324-2 Q13324-3

REFSEQ proteins: NP_001874.2

ENSEMBL proteins:

ENSP00000222836 ENSP00000344304 ENSP00000340943

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CRHR2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Corticotropin Releasing Factor Receptor 2)
	Human Recombinant Proteins from Abnova (CRHR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	8536644
GO:0005887	integral to plasma membrane	TAS	8536644

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Antibodies for CRHR2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CRHR2
	Sigma-Aldrich Antibodies for CRHR2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Corticotropin Releasing Factor Receptor 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRHR2)
	Novus Biologicals Antibodies for CRHR2

Assays for CRHR2:

	Invitrogen Assays for CRHR2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13324

ProtoNet protein and cluster: Q13324

3 Blocks protein families:

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB003051 Corticotropin releasing factor receptor signature

IPB003053 Corticotropin releasing factor type 2 receptor signature

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324

Similarity: Belongs to the G-protein coupled receptor 2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRHR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRHR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001883

Applied Biosystems Silencer® siRNAs for CRHR2

Sigma-Aldrich siRNA and siRNA Panels for CRHR2

Sigma-Aldrich shRNA Panels and shRNA for CRHR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRHR2
		Millipore Clones for the Expression of CRHR2

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001883
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001883
untagged cDNA clone in CMV expression vector: NM_001883

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001883

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324

Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding.

Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins

which activate adenylyl cyclase

Genatlas biochemistry entry for CRHR2:

corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crhr2):

	adipose tissue	behavior/neurological	endocrine/exocrine gland	hearing/vestibular/ear
homeostasis/metabolism	immune system	vision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015056	corticotrophin-releasing factor receptor activity	TAS	9717834

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CRHR2 (Your Favorite Gene powered by Ingenuity)

Corticotropin Releasing Hormone Signaling

GeneDecks CRHR2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CRHR2

5/10 Interacting proteins for CRHR2 (ENSP00000340943³) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UCN3	ENSP00000369798³	STRING (score=.996)
UCN	ENSP00000296099³	STRING (score=.995)
UCN2	ENSP00000273610³	STRING (score=.989)
CRH	ENSP00000276571³	STRING (score=.986)
POMC	ENSP00000370171³	STRING (score=.871)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	TAS	8536644

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CRHR2:

Antagonist

Compounds for CRHR2 available from Tocris Bioscience

Compound	Action	CAS number
Astressin 2B	Selective CRF2 antagonist	[681260-70-8]
K 41498	Highly selective and potent CRF2 antagonist	[434938-41-7]
CRF (human, rat)	Stimulates ACTH release	[86784-80-7]
Astressin	Potent CRF receptor antagonist	[170809-51-5]
Antisauvagine-30	Potent, selective and competitive CRF2 antagonist	[220673-95-0]

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8 Novoseek chemical compound relationships for CRHR2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine	94.75	21	15634020 (3), 15808919 (2), 9326293 (1), 15192151 (1) (see all 10)
antalarmin	79.36	1	18484196 (1)
acth	29.54	3	10822340 (2), 15165722 (1)
cyclic amp	6.98	1	10428081 (1)
calcium	0.00	1	17004937 (1)
histidine	0.00	1	15634020 (1)
tyrosine	0.00	4	17194738 (2), 15634020 (1)
proline	0.00	2	15189041 (1), 15634020 (1)

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1 PharmGKB drug compound relationship for CRHR2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
xenobiotics	FA	11526468

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRHR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRHR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001883

Sigma-Aldrich siRNA and siRNA Panels for CRHR2

Sigma-Aldrich shRNA Panels and shRNA for CRHR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001883

REFSEQ mRNAs for CRHR2 gene:

NM_001883.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001883

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001883
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001883
                                 untagged cDNA clone in CMV expression vector: NM_001883

Additional cDNA sequence:

AF011406.1 AF019381.1 AF361106.1 AF361107.1 AF361108.1 AK313661.1 AY449734.1 BC096830.1

CR617239.1 EU012439.1 EU012440.1 EU012441.1 EU012442.1 EU012443.1 U34587.1 Y10151.1

Y10152.1 Y10153.1

7 DOTS entries:

DT.92390486 DT.454252 DT.102826566 DT.91834764 DT.121046069 DT.121046077 DT.40223599

24/28 AceView cDNA sequences (see all 28 ):

AF361107 Y10153 AF361106 AF361108 Y10151 AF019381 AY449734 AF011406

Y10152 CR617239 CA389998 CD613212 U34587 CD613221 CD613207 CD613229

CD613219 CF147819 AL536395 CD613228 CD613224 NM_001883 CD613209 CD613223

highest scoring ESTs for CRHR2:

AF011406 U34587 AF019381 AF361106 AF361107 AF361108 AY449734 CF147819 BC096830 CD613206

Unigene Cluster for CRHR2:

Corticotropin releasing hormone receptor 2

Hs.546246 [show with all ESTs]

Unigene Representative Sequence: U34587

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 (see all 10 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^
SP1:											-		-		-		-		-		-		-		-		-		-		-
SP2:																							-		-		-		-		-
SP3:
SP4:															-
SP5:											-		-		-								-		-		-		-		-

ExUns:	14	^	15	^	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CRHR2

3 Ensembl transcripts including schematic representations:

ENST00000222836 ENST00000341843 ENST00000348438

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRHR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRHR2

¹ / ² / ³

6 probe-sets matching CRHR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33950_g_at²^{, 3}	U95-A	1	1.00	1.00	0.71	1.32	AF011406	1.00	1.00	1.00	1
33948_at²^{, 3}	U95-A	2	1.00	0.97	0.90	0.69	U34587	1.00	1.00	1.00	1
211510_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF019381	0.80	1.00	0.91	1
207897_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001883	0.60	1.00	0.82	1
211510_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207897_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CRHR2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTTCAGTGA

SOURCE GeneReport for Unigene cluster: Hs.546246
Expression variation in blood from EXPOLDB for CRHR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CRHR2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRHR2¹	--	corticotropin releasing hormone receptor 2	92.46(n) 96.11(a)	482384 XM_539501.2 XP_539501.2
chimpanzee (Pan troglodytes)	CRHR2¹	--	corticotropin releasing hormone receptor 2	99.38(n) 99.2(a)	748363 XM_001160981.1 XP_001160981.1
cow (Bos taurus)	CRHR2¹	--	corticotropin releasing hormone receptor 2	93.11(n) 95.13(a)	521831 XM_600101.3 XP_600101.3
rat (Rattus norvegicus)	Crhr2¹	--	corticotropin releasing hormone receptor 2	89.38(n) 93.92(a)	64680 NM_022714.1 NP_073205.1
mouse (Mus musculus)	Crhr2^{1, 5}	6 (28.00 cM)⁵	corticotropin releasing hormone receptor 2^{1, 5}	88.39(n)¹ 92.29(a)¹	12922¹ NM_009953.2¹ NP_034083.1¹ AK085854⁵ AK142261⁵ (see all 13)

About this table Species with no ortholog for CRHR2

ENSEMBL Gene Tree for CRHR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CRHR2 gene

CRHR1² PTH2R² PTH1R²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/179 NCBI SNPs in CRHR2 are shown (see all 179 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs34625936^1,2	C,F	30668872(+)	`AGGCGC/GTCAGT`	1	E/D	mis¹		5		NA EU EA WA	498
	rs8192495^1,2	H	30671755(-)	`CTACCG/ACATCG`	1	H/R	mis¹ ese³		4		EU EA WA	410
	rs8192492^1,2	H	30659687(-)	`CCCTTC/TGAGTC`	1	R/X	non¹ ese³		4		EU EA WA	418
--	rs6967702^1,2	A	30689021(+)	`ACGGAC/GAGCCC`	1	--	ng3¹		0	--	--	--	--
	rs4722998^1,2	H	30659266(+)	`AAATAG/CCTGTG`	1	--	ng5¹ ese³		4		EU EA WA	416
	rs2240403^1,2	C,F,H	30661727(+)	`TGGAAC/TGACTG`	1	S/S	syn¹ ese³		13		EA EU WA NA	3348
	rs2267716^1,2	A,C,F,H,O	30683168(+)	`GAAAAT/CGGACC`	1	--	int¹		10		EA EU WA NA	2232
	rs2190242^1,2	A,C,F,H,O	30676000(+)	`GCACAA/CATAGG`	1	--	int¹		17		EU EA WA NA	2308
	rs3779250^1,2	A,C,F,H	30660785(-)	`TACCTG/ACCACA`	1	--	int¹		5		EA EU WA	1886
	rs2251002^1,2	A,C,F,H	30679369(+)	`tttttC/Gagatg`	1	--	int¹		5		EU EA WA	1208

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HapMap Linkage Disequilibrium images for CRHR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602034

10/12 Novoseek disease relationships for CRHR2 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anxiety disorders	29.70	1	18384079 (1)
mood disorders	26.22	3	16611089 (1), 11857585 (1), 15102917 (1)
colitis	13.97	4	17412781 (2)
eating disorders	4.64	2	11526468 (1), 16634704 (1)
inflammation	4.63	5	18670748 (1), 16054139 (1)
pheochromocytoma	2.20	1	17194738 (1)
atrophy	0.00	2	15808919 (1), 16476507 (1)
genetic susceptibility	0.00	2	17532191 (1), 16691126 (1)
major depression	0.00	2	11857585 (1)
obesity	0.00	3	14724656 (3)

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1 PharmGKB disease relationship for CRHR2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
depression, anxity, eating disorder	FA	11526468

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Genetic Association Database: CRHR2
Human Genome Epidemiology Navigator: CRHR2 (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/175 PubMed articles for CRHR2 gene (see all 175 ):

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. (PubMed id 8536644)^{1, 2, 3, 4} Liaw C.W....de Souza E.B. (1996)
Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (PubMed id 11857585)^{1, 3, 6} Villafuerte S.M....Claes S. (2002)
Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)^{1, 3, 6} Challis B.G....O'Rahilly S. (2004)
Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. (PubMed id 16175604)^{3, 6} Kato N....Omata M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. (PubMed id 11526468)^{1, 7} Hiroi N....Bornstein S.R. (2001)
Molecular identification and analysis of a novel human corticotropin- releasing factor (CRF) receptor: the CRF2gamma receptor. (PubMed id 9717834)^{3, 4} Kostich W.A.... Largent B.L. (1998)
A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. (PubMed id 9199241)^{3, 4} Valdenaire O.... Kilpatrick G. (1997)
The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways. (PubMed id 19058138)^{1, 3} Tezval H....Merseburger A.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1395	HGNC: 2358	AceView: CRHR2	Ensembl:ENSG00000106113	euGenes: HUgn1395
ECgene: CRHR2	H-InvDB: CRHR2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for CRHR2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CRHR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CRHR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CRHR2		Antibodies for CRHR2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CRHR2		Small molecules for CRHR2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CRHR2)
	Antibodies (CRHR2)
	Chimera RNAi (CRHR2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Corticotropin Releasing Factor Receptor 2)
	Antibodies (Corticotropin Releasing Factor Receptor 2)

Search OriGene for CRHR2

Tocris compounds for CRHR2

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Antibodies for CRHR2

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CRHR2 Gene at Home site.
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CRHR2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CRHR2

Summaries
for CRHR2

Genomic Location
for CRHR2

Proteins
for CRHR2

Protein Domains/
Families
for CRHR2

Gene Function
for CRHR2

Pathways & Interactions
for CRHR2

Drugs & Compounds
for CRHR2

Transcripts
for CRHR2

Expression
for CRHR2

Orthologs
for CRHR2

Paralogs
for CRHR2

SNPs/Variants
for CRHR2

Disorders & Mutations
for CRHR2

Medical News
for CRHR2

Publications
for CRHR2

Search for CRHR2

Genome Databases showing CRHR2

Other Databases showing CRHR2

Specialized Databases showing CRHR2

Licensable Technologies
for CRHR2

Services
for CRHR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRHR2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CRHR2

Summariesfor CRHR2

Genomic Locationfor CRHR2

Proteinsfor CRHR2

Protein Domains/Familiesfor CRHR2

Gene Functionfor CRHR2

Pathways & Interactionsfor CRHR2

Drugs & Compoundsfor CRHR2

Transcriptsfor CRHR2

Expression for CRHR2

Orthologsfor CRHR2

Paralogsfor CRHR2

SNPs/Variantsfor CRHR2

Disorders & Mutationsfor CRHR2

Medical Newsfor CRHR2

Publicationsfor CRHR2

Search for CRHR2

Genome Databases showing CRHR2

Other Databases showing CRHR2

Specialized Databases showing CRHR2

Licensable Technologiesfor CRHR2

Servicesfor CRHR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRHR2

Summaries
for CRHR2

Genomic Location
for CRHR2

Proteins
for CRHR2

Protein Domains/
Families
for CRHR2

Gene Function
for CRHR2

Pathways & Interactions
for CRHR2

Drugs & Compounds
for CRHR2

Transcripts
for CRHR2

Expression
for CRHR2

Orthologs
for CRHR2

Paralogs
for CRHR2

SNPs/Variants
for CRHR2

Disorders & Mutations
for CRHR2

Medical News
for CRHR2

Publications
for CRHR2

Licensable Technologies
for CRHR2

Services
for CRHR2