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Aliases for CRHR2 Gene

Aliases for CRHR2 Gene

  • Corticotropin Releasing Hormone Receptor 2 2 3
  • CRH-R2 3 4
  • CRFR2 3 6
  • Corticotropin-Releasing Hormone Receptor 2 4
  • Corticotropin-Releasing Factor Receptor 2 3
  • CRF2 Receptor, Beta Isoform 3
  • CRH Receptor 2 Variant B 3
  • CRF-R-2 4
  • CRH-R-2 4
  • CRF-RB 3
  • HM-CRF 3
  • CRF-R2 4
  • CRFR-2 4
  • CRF2R 4
  • CRH2R 4
  • CRF2 3

External Ids for CRHR2 Gene

Summaries for CRHR2 Gene

Entrez Gene Summary for CRHR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for CRHR2 Gene

CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include hormone activity and corticotrophin-releasing factor receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for CRHR2 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels

Tocris Summary for CRHR2 Gene

  • The corticotropin-release factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display different tissue distribution but the pharmacological and biological properties remain unchanged. The physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHR2 Gene

Genomics for CRHR2 Gene

Genomic Location for CRHR2 Gene

Start:
30,651,943 bp from pter
End:
30,700,129 bp from pter
Size:
48,187 bases
Orientation:
Minus strand

Genomic View for CRHR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR2 Gene

Regulatory Elements for CRHR2 Gene

Proteins for CRHR2 Gene

  • Protein details for CRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13324-CRFR2_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 2
    Protein Accession:
    Q13324
    Secondary Accessions:
    • B2R967
    • B3SXS6
    • B3SXS7
    • B3SXS8
    • B3SXT0
    • F8WA81
    • O43461
    • Q4QRJ4
    • Q99431

    Protein attributes for CRHR2 Gene

    Size:
    411 amino acids
    Molecular mass:
    47688 Da
    Quaternary structure:
    • Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

    Three dimensional structures from OCA and Proteopedia for CRHR2 Gene

    Alternative splice isoforms for CRHR2 Gene

neXtProt entry for CRHR2 Gene

Proteomics data for CRHR2 Gene at MOPED

Post-translational modifications for CRHR2 Gene

  • A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn41, Asn74, Asn86, and Asn94

No data available for DME Specific Peptides for CRHR2 Gene

Domains for CRHR2 Gene

Gene Families for CRHR2 Gene

HGNC:
  • CRHR :GPCR / Class B : Corticotropin-releasing factor receptors
IUPHAR :

UniProtKB/Swiss-Prot:

CRFR2_HUMAN
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).:
    • Q13324
  • The uncleaved pseudo signal peptide prevents receptors oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).:
    • Q13324
Family:
  • Belongs to the G-protein coupled receptor 2 family.:
    • Q13324
genes like me logo Genes that share domains with CRHR2: view

Function for CRHR2 Gene

Molecular function for CRHR2 Gene

GENATLAS Biochemistry: corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels

Gene Ontology (GO) - Molecular Function for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IPI 11329063
GO:0015056 corticotrophin-releasing factor receptor activity IEA --
genes like me logo Genes that share ontologies with CRHR2: view
genes like me logo Genes that share phenotypes with CRHR2: view

Animal Models for CRHR2 Gene

MGI Knock Outs for CRHR2:

miRNA for CRHR2 Gene

miRTarBase miRNAs that target CRHR2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRHR2 Gene

Localization for CRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRHR2 Gene COMPARTMENTS Subcellular localization image for CRHR2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8536644
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CRHR2: view

Pathways for CRHR2 Gene

genes like me logo Genes that share pathways with CRHR2: view

Pathways by source for CRHR2 Gene

Gene Ontology (GO) - Biological Process for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 8536644
GO:0016525 negative regulation of angiogenesis IEA --
GO:0043950 positive regulation of cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with CRHR2: view

Compounds for CRHR2 Gene

(3) Tocris Compounds for CRHR2 Gene

Compound Action Cas Number
Antisauvagine-30 Potent, selective and competitive CRF2 antagonist [220673-95-0]
Astressin 2B Selective CRF2 antagonist [681260-70-8]
K 41498 Highly selective and potent CRF2 antagonist [434938-41-7]

(16) IUPHAR Ligand for CRHR2 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]urocortin 1 (mouse, rat) Agonist Full agonist 10
[125I]sauvagine (frog) Agonist Full agonist 10
[125I]antisauvagine Antagonist Antagonist 9.9
urocortin 1 Agonist Full agonist 9.8
urocortin 1 Agonist Full agonist 9.8
antisauvagine Antagonist Antagonist 9.6
urotensin 1 (fish) Agonist Full agonist 9.4
[125I]astressin Antagonist Antagonist 9.3
sauvagine Agonist Full agonist 9.2
K41498 Antagonist Antagonist 9.2
CRF Agonist Full agonist 9
CRF Agonist Full agonist 9
astressin Antagonist Antagonist 8.8
K31440 Antagonist Antagonist 8.8
urocortin 3 Agonist Full agonist 8
urocortin 2 Agonist Full agonist 5.4

(12) Novoseek inferred chemical compound relationships for CRHR2 Gene

Compound -log(P) Hits PubMed IDs
sauvagine 94.4 13
astressin 92.3 4
antalarmin 80.9 1
acth 27.8 3
adenylate 18.2 1

(2) PharmGKB related drug/compound annotations for CRHR2 Gene

Drug/compound Annotation
salbutamol CA
selective beta-2-adrenoreceptor agonists CA
genes like me logo Genes that share compounds with CRHR2: view

Transcripts for CRHR2 Gene

Unigene Clusters for CRHR2 Gene

Corticotropin releasing hormone receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - -
SP9:
SP10: - - - - - - - - - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CRHR2 Gene

GeneLoc Exon Structure for
CRHR2
ECgene alternative splicing isoforms for
CRHR2

Expression for CRHR2 Gene

mRNA expression in normal human tissues for CRHR2 Gene

mRNA differential expression in normal tissues according to GTEx for CRHR2 Gene

This gene is overexpressed in Pituitary (7.1).

SOURCE GeneReport for Unigene cluster for CRHR2 Gene Hs.546246

genes like me logo Genes that share expressions with CRHR2: view

Orthologs for CRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRHR2 36
  • 99.27 (n)
  • 98.78 (a)
CRHR2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRHR2 36
  • 93.09 (n)
  • 95.12 (a)
CRHR2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRHR2 36
  • 92.44 (n)
  • 96.1 (a)
CRHR2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crhr2 36
  • 88.24 (n)
  • 92.57 (a)
Crhr2 16
Crhr2 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRHR2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHR2 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crhr2 36
  • 89.35 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves CRHR2 36
  • 77.33 (n)
  • 88.71 (a)
CRHR2 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRHR2 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia crhr2-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia crhr2 36
  • 76.74 (n)
  • 86.1 (a)
zebrafish
(Danio rerio)
Actinopterygii CRHR2 37
  • 77 (a)
OneToOne
LOC100335005 36
  • 72.95 (n)
  • 81.14 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH2 36
  • 53.67 (n)
  • 41.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dh44-R1 36
  • 53.08 (n)
  • 41.04 (a)
Dh44-R1 37
  • 31 (a)
ManyToMany
Dh44-R2 37
  • 34 (a)
ManyToMany
CG8422 38
  • 39 (a)
CG12370 38
  • 40 (a)
EG:BACR25B3.3 38
  • 31 (a)
Species with no ortholog for CRHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRHR2 Gene

ENSEMBL:
Gene Tree for CRHR2 (if available)
TreeFam:
Gene Tree for CRHR2 (if available)

Paralogs for CRHR2 Gene

Selected SIMAP similar genes for CRHR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CRHR2: view

Variants for CRHR2 Gene

Sequence variations from dbSNP and Humsavar for CRHR2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs38027 -- 30,653,989(+) GTGTG(C/T)GCCCA intron-variant
rs38028 -- 30,663,122(+) AGAGC(A/G)AGAGT intron-variant
rs107540 -- 30,700,075(+) TGCCC(A/C/G)GCACG utr-variant-5-prime, upstream-variant-2KB
rs255097 -- 30,687,343(+) GATGC(A/G)GTGGT intron-variant
rs255098 -- 30,687,711(+) AGAGC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRHR2 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv527038 CNV Gain 19592680
nsv830938 CNV Gain 17160897
esv2734201 CNV Deletion 23290073
esv1664845 CNV Insertion 17803354

Relevant External Links for CRHR2 Gene

HapMap Linkage Disequilibrium report
CRHR2

Disorders for CRHR2 Gene

(1) University of Copenhagen DISEASES for CRHR2 Gene

(12) Novoseek inferred disease relationships for CRHR2 Gene

Disease -log(P) Hits PubMed IDs
anxiety disorders 40.5 1
mood disorders 23.6 3
colitis 11.3 2
genetic susceptibility 8.4 3
eating disorders 1.92 2

Relevant External Links for CRHR2

Genetic Association Database (GAD)
CRHR2
Human Genome Epidemiology (HuGE) Navigator
CRHR2
genes like me logo Genes that share disorders with CRHR2: view

No data available for UniProtKB/Swiss-Prot for CRHR2 Gene

Publications for CRHR2 Gene

  1. Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (PMID: 11857585) Villafuerte S.M. … Claes S. (Am. J. Med. Genet. 2002) 3 23 49
  2. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PMID: 14724656) Challis B.G. … O'Rahilly S. (Int. J. Obes. Relat. Metab. Disord. 2004) 3 23 49
  3. Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder. (PMID: 16691126) Tharmalingam S. … Kennedy J.L. (Psychiatr. Genet. 2006) 3 23 49
  4. Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits. (PMID: 16884458) Tochigi M. … Sasaki T. (Psychiatry Clin. Neurosci. 2006) 3 23 49
  5. Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder. (PMID: 17532191) De Luca V. … Kennedy J.L. (Eur. Psychiatry 2007) 3 23 49

Products for CRHR2 Gene

Sources for CRHR2 Gene

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