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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRHR2 Gene

protein-coding   GIFtS: 61
GCID: GC07M030658

corticotropin releasing hormone receptor 2
 Explore 28 diseases affiliated with
CRHR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRHR2    

Aliases
for CRHR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Corticotropin Releasing Hormone Receptor 21 2     CRF-R-23
CRF-RB1 2     CRF-R23
CRF21 2     CRF2R3
HM-CRF1 2     CRFR-23
CRH-R22 3     CRH-R-23
CRFR22 5     CRH2R3
Corticotropin-Releasing Factor Receptor 22     Corticotropin-Releasing Hormone Receptor 23
CRF2 Receptor, Beta Isoform2     

External Ids:    HGNC: 23581   Entrez Gene: 13952   Ensembl: ENSG000001061137   OMIM: 6020345   UniProtKB: Q133243   

Export aliases for CRHR2 gene to outside databases

Previous GC identifers: GC07M030334 GC07M030434 GC07M030465 GC07M030574


Summaries
for CRHR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRHR2:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin
releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also
binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in
coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice
suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene.(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to
urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

summary for CRHR2:
The corticotropin-release factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family
of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been
identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display
different tissue distribution but the pharmacological and biological properties remain unchanged. The
physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known
to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet
cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR2 (Corticotropin releasing hormone receptor 2)


Genomic Views
for CRHR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRHR2 gene promoter:
         MEF-2   HTF   HNF-4alpha1   RORalpha2   MEF-2A   POU2F1   Zic1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRHR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRHR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p21-p15

CRHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030658:  view genomic region     (about GC identifiers)

Start:
 30,692,200 bp from pter      End:
 30,739,745 bp from pter
Size:
 47,546 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 30,742,515-30,771,785     

Proteins
for CRHR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324 (See protein sequence)
Recommended Name: Corticotropin-releasing factor receptor 2 precursor  
Size: 411 amino acids; 47688 Da
Subunit: Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN,
and considerably lower affinity for CRF, UNC2 and UCN3
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for CRHR2:
3N93 (3D)        3N95 (3D)        3N96 (3D)    
Secondary accessions: O43461 Q4QRJ4 Q99431
Alternative splicing: 3 isoforms:  Q13324-1   Q13324-2   Q13324-3   

Explore the universe of human proteins at neXtProt for CRHR2: NX_Q13324

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13324

    • CRHR2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (5 alternative transcripts): 
    NP_001189404.1  NP_001189410.1  NP_001189411.1  NP_001189412.1  NP_001874.2  

    ENSEMBL proteins: 
     ENSP00000418722   ENSP00000401930   ENSP00000340943   ENSP00000401241   ENSP00000416620  
     ENSP00000344304   ENSP00000426498  
    Reactome Protein details: Q13324
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CRHR2 Protein
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate: CRHR2
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    Novus Biologicals CRHR2 Proteins
    Novus Biologicals CRHR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CRHR2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8536644
    GO:0009986cell surface IEA--


    CRHR2 for ontologies           About GeneDecksing



    CRHR2 Antibody Products: 
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    Uscn Antibodies for CRHR2
    ThermoFisher Antibodies for CRHR2

    Assay Products for CRHR2: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CRHR2

    Protein Domains /
    Families
    for CRHR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRHR2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003051 GPCR_2_CRF_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q13324

    ProtoNet protein and cluster: Q13324

    3 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003051 Corticotropin releasing factor receptor signature
    IPB003053 Corticotropin releasing factor type 2 receptor signature


    UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for CRHR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
    Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to
    urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

         Genatlas biochemistry entry for CRHR2:
    corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CRHR2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHR2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHR2:
    hsa-miR-299-5p hsa-miR-92a-1* hsa-miR-4328 hsa-miR-558 hsa-miR-2278 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmid: CRHR2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHR2 (see all 7)
    OriGene shRNA RFP: CRHR2
    OriGene siRNA: CRHR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CRHR2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRHR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRHR2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): CRHR2 (NM_001883)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CRHR2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI11329063
    GO:0015056corticotrophin-releasing factor receptor activity IEA--


    CRHR2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CRHR2: Crhr2tm1Klee Crhr2tm1Jsp Crhr2tm1Mpsp
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crhr2):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  hearing/vestibular/ear 
     homeostasis/metabolism  immune system  vision/eye 

    CRHR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRHR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		cAMP Pathway0.77
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    4G beta:gamma signalling through PLC beta
    		Class B/2 (Secretin family receptors)0.20
    		G alpha (s) signalling events0.14
    5Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
    		Glucocorticoid Pathway (HPA Axis), Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CRHR2
        Adenylate cyclase-activating neuropeptides

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRHR2
        cAMP Pathway
    CRHR Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for CRHR2 
        GPCRs, Class B Secretin-like

    5/6        Reactome Pathways for CRHR2 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)

    1 PharmGKB Pathway for CRHR2
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for CRHR2):
        Neuroactive ligand-receptor interaction


    CRHR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRHR2

    4 Interacting proteins for CRHR2 (Q133243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893I2D: score=3 
    CRHP068503I2D: score=2 
    UCN2Q96RP33I2D: score=1 
    UCN3Q969E33I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8536644
    GO:0016525negative regulation of angiogenesis IEA--
    GO:0043950positive regulation of cAMP-mediated signaling IEA--
    GO:0043951negative regulation of cAMP-mediated signaling IEA--


    CRHR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRHR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRHR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CRHR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Astressin 2BSelective CRF2 antagonist[681260-70-8]
    K 41498Highly selective and potent CRF2 antagonist[434938-41-7]
    CRF (human, rat) Stimulates ACTH release[86784-80-7]
    AstressinPotent CRF receptor antagonist[170809-51-5]
    Antisauvagine-30 Potent, selective and competitive CRF2 antagonist [220673-95-0]
    10/12 Novoseek chemical compound relationships for CRHR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 94.4 21 15634020 (3), 15808919 (2), 9326293 (1), 15192151 (1) (see all 10)
    astressin 92.3 6 19703147 (1), 19628576 (1), 16920976 (1), 18052377 (1)
    antalarmin 80.9 1 18484196 (1)
    acth 27.8 3 10822340 (2), 15165722 (1)
    adenylate 18.2 1 16888152 (1)
    cyclic amp 5.17 1 10428081 (1)
    calcium 0 1 17004937 (1)
    tyrosine 0 4 17194738 (2), 15634020 (1)
    proline 0 2 15189041 (1), 15634020 (1)
    histidine 0 1 15634020 (1)

    2 PharmGKB related drug/compound annotations for CRHR2 gene
    Drug/compound PharmGKB Annotation
    salbutamolCA  
    selective beta-2-adrenoreceptor agonistsCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CRHR2 / CRFR2 

    Transcripts
    for CRHR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRHR2 gene (5 alternative transcripts): 
    NM_001202475.1  NM_001202481.1  NM_001202482.1  NM_001202483.1  NM_001883.4  

    Unigene Clusters for CRHR2:

    Corticotropin releasing hormone receptor 2
    Hs.546246  [show with all ESTs], Hs.729970  [show with all ESTs]
    Unigene Representative Sequences: NM_001202481, AF361108
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471646(uc010kvw.2 uc003tbn.3 uc010kvx.2 uc022abg.1 uc010kvy.2 uc003tbo.3 uc003tbp.3)
    ENST00000452278 ENST00000348438(uc010kvz.1) ENST00000445981(uc010kwa.1)
    ENST00000423776(uc003tbr.1) ENST00000462882(uc010kwb.1) ENST00000341843
    ENST00000506074

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHR2:
    hsa-miR-299-5p hsa-miR-92a-1* hsa-miR-4328 hsa-miR-558 hsa-miR-2278 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmid: CRHR2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHR2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF361107.1 AF361108.1 

    7 DOTS entries:

    DT.92390486  DT.454252  DT.102826566  DT.121046069  DT.121046077  DT.40223599  DT.91834764 

    24/28 AceView cDNA sequences (see all 28):

    CR617239 Y10151 AY449734 AF019381 AF011406 AF361107 Y10152 AF361106 
    CA389998 Y10153 AF361108 CD613224 CD613228 CD613212 CD613229 CF147819 
    CD613209 AL536395 U34587 CD613221 CD613219 CD613223 NM_001883 CD613207 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                -     -     -     -     -     -     -     -     -     -     -                                                               
    SP2:                                                                    -     -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                            -                                                                                                               
    SP5:                                -     -     -                       -     -     -     -     -                                                               

    ExUns: 14 ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CRHR2

    Expression
    for CRHR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRHR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTCAGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRHR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for CRHR2

    SOURCE GeneReport for Unigene clusters: Hs.546246 Hs.729970
        SABiosciences Expression via Pathway-Focused PCR Arrays including CRHR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CRHR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CRHR2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CRHR21 corticotropin releasing hormone receptor 2 74.84(n)
    83.82(a)    		   395105  NM_204454.1  NP_989785.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CRHR26
    		 --
    		 83(a)
    		 1 ↔ 1
    		 6(1447699-1561925)
    African clawed frog
    (Xenopus laevis)    		 Amphibia crhr2-A2 corticotropin releasing hormone receptor 2 78.44(n)    Y14037.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003350051 corticotropin-releasing factor receptor 2-like 72.63(n)
    80.39(a)    		   100335005  XM_002667848.2  XP_002667894.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG123703
    Dh44-R11    		 G-protein coupled receptor protein signaling
    pathway more3
    Diuretic hormone 44 receptor 11    		 40(a)
    (best of 3)3
    52.99(n)1
    40.75(a)1    		   49A93
    366011  NM_137116.21  NP_610960.11 


    ENSEMBL Gene Tree for CRHR2 (if available)
    TreeFam Gene Tree for CRHR2 (if available) 

    Paralogs
    for CRHR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRHR2 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  VIPR12  CRHR12  PTH2R2  
    CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for CRHR2 using alignment to 10 protein entries:     CRFR2_HUMAN (see all proteins):
    CRHR1    SCTR    VIPR1    CALCRL    CALCR    VIPR2
    GLP2R    GIPR    PTH1R    GCGR    ADCYAP1R1    GHRHR
    GLP1R

    CRHR2 for paralogs           About GeneDecksing



    Genomic Variants
    for CRHR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/827 NCBI SNPs in CRHR2 are shown (see all 827)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs133126381,2
    		H--30621490(+) GAGCAG/AGCAGA 3 /L syn1 ut514Minor allele frequency- A:0.00NS EA 418
    rs1899517481,2
    		--30691497(+) GGTCAG/TGTGTT 5 -- ds50010--------
    rs1448169291,2
    		--30691562(+) ATGTAC/TTTTAA 5 -- ut310--------
    rs1811735661,2
    		--30691687(+) AAGACA/GGGATA 5 -- ut310--------
    rs1851369361,2
    		--30691810(+) ACAGGA/GACGGA 5 -- ut310--------
    rs2011649001,2
    		--30691904(+) ACAGG-/CCCCTG 5 -- ut310--------
    rs37354301,2
    		C,F,H,--30691986(-) ACCAGG/ACTAAT 5 -- ut3111Minor allele frequency- A:0.14EA NS NA 2910
    rs1485637861,2
    		--30692355(+) TCCTCA/GTTTTG 5 -- ut310--------
    rs1443709861,2
    		--30692614(+) GCTGGC/TGTACC 5 -- ut310--------
    rs1818766861,2
    		--30692615(+) CTGGCA/GTACCC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for CRHR2 (30692200 - 30739745 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CRHR2: --

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    Disorders / Diseases
    for CRHR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRHR2 for disorders           About GeneDecksing

    OMIM gene information: 602034    OMIM disorders: --

    20/28 diseases for CRHR2 (see all 28):    About MalaCards
    bacterial vaginosis    anxiety disorder    eating disorder    autonomic dysfunction
    irritable bowel syndrome    drug dependence    anorexia nervosa    panic disorder
    adrenocortical tumor    renal cell carcinoma    pheochromocytoma    bipolar disorder
    hepatitis c    endometrial cancer    obesity    hepatocellular carcinoma
    ovarian cancer    lung carcinoma    carcinoma    prostate cancer

    10/12 Novoseek disease relationships for CRHR2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anxiety disorders 40.5 1 18384079 (1)
    mood disorders 23.6 3 16611089 (1), 11857585 (1), 15102917 (1)
    colitis 11.3 4 17412781 (2)
    genetic susceptibility 8.4 3 18838498 (1), 17532191 (1), 16691126 (1)
    eating disorders 1.92 2 11526468 (1), 16634704 (1)
    inflammation 0.715 5 18670748 (1), 16054139 (1)
    atrophy 0 2 15808919 (1), 16476507 (1)
    tachycardia 0 1 12786991 (1)
    pheochromocytoma 0 1 17194738 (1)
    tumors 0 16 19433256 (3), 19968503 (1), 19058138 (1)

    Genetic Association Database (GAD): CRHR2
    Human Genome Epidemiology (HuGE) Navigator: CRHR2 (33 documents)

    Export disorders for CRHR2 gene to outside databases

    Publications
    for CRHR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRHR2 gene, integrated from 9 sources (see all 212):
    (articles sorted by number of sources associating them with CRHR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. (PubMed id 8536644)1, 2, 3 Liaw C.W....de Souza E.B. (1996)
    2. Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (PubMed id 11857585)1, 4, 9 Villafuerte S.M....Claes S. (2002)
    3. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)1, 4, 9 Challis B.G....O'Rahilly S. (2004)
    4. Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. (PubMed id 20966082)1, 2 Pal K....Pioszak A.A. (2010)
    5. Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. (PubMed id 16175604)1, 4 Kato N....Omata M. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Molecular identification and analysis of a novel human corticotropin- releasing factor (CRF) receptor: the CRF2gamma receptor. (PubMed id 9717834)1, 2 Kostich W.A.... Largent B.L. (1998)
    9. A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor. (PubMed id 9199241)1, 2 Valdenaire O.... Kilpatrick G. (1997)
    10. The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways. (PubMed id 19058138)1, 9 Tezval H....Merseburger A.S. (2009)

    External Searches for CRHR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRHR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1395 HGNC: 2358 AceView: CRHR2 Ensembl:ENSG00000106113 euGenes: HUgn1395
    ECgene: CRHR2 Kegg: 1395 H-InvDB: CRHR2

    Other Databases showing CRHR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRHR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRHR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CRHR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRHR2 gene:
    Search GeneIP for patents involving CRHR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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