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Aliases for CRHR2 Gene

Aliases for CRHR2 Gene

  • Corticotropin Releasing Hormone Receptor 2 2 3 5
  • CRH-R2 3 4
  • Corticotropin-Releasing Hormone Receptor 2 4
  • CRF2 Receptor, Beta Isoform 3
  • CRH Receptor 2 Variant B 3
  • CRF-R-2 4
  • CRH-R-2 4
  • CRF-RB 3
  • HM-CRF 3
  • CRF-R2 4
  • CRFR-2 4
  • CRFR2 3
  • CRF2R 4
  • CRH2R 4
  • CRF2 3

External Ids for CRHR2 Gene

Previous GeneCards Identifiers for CRHR2 Gene

  • GC07M030334
  • GC07M030434
  • GC07M030465
  • GC07M030658
  • GC07M030574

Summaries for CRHR2 Gene

Entrez Gene Summary for CRHR2 Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

GeneCards Summary for CRHR2 Gene

CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Diseases associated with CRHR2 include chemical colitis. Among its related pathways are Signaling by GPCR and Corticotropin-releasing hormone. GO annotations related to this gene include G-protein coupled receptor activity and hormone activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for CRHR2 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Tocris Summary for CRHR2 Gene

  • The corticotropin-releasing factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c.

Gene Wiki entry for CRHR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHR2 Gene

Genomics for CRHR2 Gene

Regulatory Elements for CRHR2 Gene

Genomic Location for CRHR2 Gene

Chromosome:
7
Start:
30,651,843 bp from pter
End:
30,700,129 bp from pter
Size:
48,287 bases
Orientation:
Minus strand

Genomic View for CRHR2 Gene

Genes around CRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR2 Gene

Proteins for CRHR2 Gene

  • Protein details for CRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13324-CRFR2_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 2
    Protein Accession:
    Q13324
    Secondary Accessions:
    • B2R967
    • B3SXS6
    • B3SXS7
    • B3SXS8
    • B3SXT0
    • F8WA81
    • O43461
    • Q4QRJ4
    • Q99431

    Protein attributes for CRHR2 Gene

    Size:
    411 amino acids
    Molecular mass:
    47688 Da
    Quaternary structure:
    • Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.

    Three dimensional structures from OCA and Proteopedia for CRHR2 Gene

    Alternative splice isoforms for CRHR2 Gene

neXtProt entry for CRHR2 Gene

Proteomics data for CRHR2 Gene at MOPED

Post-translational modifications for CRHR2 Gene

  • A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
  • Glycosylation at Asn 41, Asn 74, Asn 86, and Asn 94
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CRHR2 Gene

Domains & Families for CRHR2 Gene

Gene Families for CRHR2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13324

UniProtKB/Swiss-Prot:

CRFR2_HUMAN :
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • Belongs to the G-protein coupled receptor 2 family.
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).
  • The uncleaved pseudo signal peptide prevents receptors oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR2: view

Function for CRHR2 Gene

Molecular function for CRHR2 Gene

GENATLAS Biochemistry:
corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Gene Ontology (GO) - Molecular Function for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015056 corticotrophin-releasing factor receptor activity TAS 9717834
genes like me logo Genes that share ontologies with CRHR2: view
genes like me logo Genes that share phenotypes with CRHR2: view

Animal Models for CRHR2 Gene

MGI Knock Outs for CRHR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRHR2

miRNA for CRHR2 Gene

miRTarBase miRNAs that target CRHR2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRHR2 Gene

Localization for CRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRHR2 Gene COMPARTMENTS Subcellular localization image for CRHR2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with CRHR2: view

Pathways & Interactions for CRHR2 Gene

genes like me logo Genes that share pathways with CRHR2: view

Pathways by source for CRHR2 Gene

Gene Ontology (GO) - Biological Process for CRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 8536644
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0010460 positive regulation of heart rate IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0019233 sensory perception of pain IEA --
genes like me logo Genes that share ontologies with CRHR2: view

No data available for SIGNOR curated interactions for CRHR2 Gene

Drugs & Compounds for CRHR2 Gene

(26) Drugs for CRHR2 Gene - From: Novoseek, PharmGKB, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 494
Salbutamol Approved Pharma Partial agonist, Agonist 0
corticotropin-releasing factor Investigational Pharma 0
Astressin Pharma Antagonist 2
Sauvagine Pharma Full agonist, Agonist CRF agonist 0

(5) Additional Compounds for CRHR2 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Antisauvagine-30
220673-95-0
Astressin 2B
681260-70-8
K 41498
434938-41-7
genes like me logo Genes that share compounds with CRHR2: view

Transcripts for CRHR2 Gene

Unigene Clusters for CRHR2 Gene

Corticotropin releasing hormone receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5: - - - - - - - -
SP6: - - - - -
SP7: -
SP8: - - - - - - - -
SP9:
SP10: - - - - - - - - - - - -

ExUns: 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CRHR2 Gene

GeneLoc Exon Structure for
CRHR2
ECgene alternative splicing isoforms for
CRHR2

Expression for CRHR2 Gene

mRNA expression in normal human tissues for CRHR2 Gene

mRNA differential expression in normal tissues according to GTEx for CRHR2 Gene

This gene is overexpressed in Pituitary (x7.1).

SOURCE GeneReport for Unigene cluster for CRHR2 Gene Hs.546246

genes like me logo Genes that share expression patterns with CRHR2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CRHR2 Gene

Orthologs for CRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRHR2 35
  • 93.09 (n)
  • 95.12 (a)
CRHR2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRHR2 35
  • 92.44 (n)
  • 96.1 (a)
CRHR2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crhr2 35
  • 88.24 (n)
  • 92.57 (a)
Crhr2 16
Crhr2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRHR2 35
  • 99.27 (n)
  • 98.78 (a)
CRHR2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crhr2 35
  • 89.35 (n)
  • 93.9 (a)
oppossum
(Monodelphis domestica)
Mammalia CRHR2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHR2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRHR2 35
  • 77.33 (n)
  • 88.71 (a)
CRHR2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRHR2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crhr2 35
  • 76.74 (n)
  • 86.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia crhr2-A 35
zebrafish
(Danio rerio)
Actinopterygii LOC100335005 35
  • 72.95 (n)
  • 81.14 (a)
CRHR2 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12370 37
  • 40 (a)
CG8422 37
  • 39 (a)
EG:BACR25B3.3 37
  • 31 (a)
Dh44-R1 35
  • 53.08 (n)
  • 41.04 (a)
Dh44-R1 36
  • 31 (a)
ManyToMany
Dh44-R2 36
  • 34 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH2 35
  • 53.67 (n)
  • 41.94 (a)
Species with no ortholog for CRHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRHR2 Gene

ENSEMBL:
Gene Tree for CRHR2 (if available)
TreeFam:
Gene Tree for CRHR2 (if available)

Paralogs for CRHR2 Gene

(13) SIMAP similar genes for CRHR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CRHR2: view

Variants for CRHR2 Gene

Sequence variations from dbSNP and Humsavar for CRHR2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34625936 - 30,662,731(+) AGGCG(C/G)TCAGT reference, missense
rs38027 -- 30,653,989(+) GTGTG(C/T)GCCCA intron-variant, utr-variant-3-prime
rs38028 -- 30,663,122(+) AGAGC(A/G)AGAGT intron-variant
rs255097 -- 30,687,343(+) GATGC(A/C/G)GTGGT intron-variant
rs255098 -- 30,687,711(+) AGAGC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRHR2 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv527038 CNV Gain 19592680
nsv830938 CNV Gain 17160897
esv2734201 CNV Deletion 23290073
esv1664845 CNV Insertion 17803354

Variation tolerance for CRHR2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRHR2 Gene

HapMap Linkage Disequilibrium report
CRHR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR2 Gene

Disorders for CRHR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CRHR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search CRHR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRHR2

Genetic Association Database (GAD)
CRHR2
Human Genome Epidemiology (HuGE) Navigator
CRHR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRHR2
genes like me logo Genes that share disorders with CRHR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRHR2 Gene

Publications for CRHR2 Gene

  1. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. (PMID: 8536644) Liaw C.W. … de Souza E.B. (Endocrinology 1996) 2 3 4 67
  2. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. (PMID: 19813023) Gu X. … Gao C. (Hum. Genet. 2010) 3 23
  3. A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth. (PMID: 20164545) Schmid M. … Egarter C. (Dis. Markers 2010) 3 23
  4. The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways. (PMID: 19058138) Tezval H. … Merseburger A.S. (Prostate 2009) 3 23
  5. Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells. (PMID: 19351656) Yata A. … Maruo T. (Hum. Reprod. 2009) 3 23

Products for CRHR2 Gene

Sources for CRHR2 Gene

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