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CRHR2 Gene

protein-coding   GIFtS: 65
GCID: GC07M030658

Corticotropin Releasing Hormone Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Corticotropin Releasing Hormone Receptor 21 2     CRH Receptor 2 Variant B2
CRH-R22 3     CRF-R-23
CRFR22 5     CRF-R23
CRF-RB2     CRF2R3
CRF22     CRFR-23
HM-CRF2     CRH-R-23
Corticotropin-Releasing Factor Receptor 22     CRH2R3
CRF2 Receptor, Beta Isoform2     Corticotropin-Releasing Hormone Receptor 23

External Ids:    HGNC: 23581   Entrez Gene: 13952   Ensembl: ENSG000001061137   OMIM: 6020345   UniProtKB: Q133243   

Export aliases for CRHR2 gene to outside databases

Previous GC identifers: GC07M030334 GC07M030434 GC07M030465 GC07M030574


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRHR2 Gene:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of
corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone
(CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays
an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune
challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.(provided
by RefSeq, Jan 2011)

GeneCards Summary for CRHR2 Gene:
CRHR2 (corticotropin releasing hormone receptor 2) is a protein-coding gene. Diseases associated with CRHR2 include autonomic dysfunction, and eating disorder. GO annotations related to this gene include corticotrophin-releasing factor receptor activity and hormone activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
Function: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has
high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine
nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the
activation of adenylate cyclase, leading to increased intracellular cAMP levels

summary for CRHR2 Gene:
The corticotropin-release factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family
of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been
identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display
different tissue distribution but the pharmacological and biological properties remain unchanged. The
physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known
to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet
cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR2 (Corticotropin releasing hormone receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRHR2 gene promoter:
         MEF-2   HTF   HNF-4alpha1   RORalpha2   MEF-2A   POU2F1   Zic1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRHR2 promoter sequence
   Search Chromatin IP Primers for CRHR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p21-p15

CRHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030658:  view genomic region     (about GC identifiers)

Start:
30,691,559 bp from pter      End:
30,739,745 bp from pter
Size:
48,187 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 30,741,211-30,789,281     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324 (See protein sequence)
Recommended Name: Corticotropin-releasing factor receptor 2  
Size: 411 amino acids; 47688 Da
Subunit: Monomer. Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest
affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3
3 PDB 3D structures from and Proteopedia for CRHR2:
3N93 (3D)        3N95 (3D)        3N96 (3D)    
Secondary accessions: B2R967 B3SXS6 B3SXS7 B3SXS8 B3SXT0 F8WA81 O43461 Q4QRJ4 Q99431
Alternative splicing: 7 isoforms:  Q13324-1   Q13324-2   Q13324-3   Q13324-4   Q13324-5   Q13324-6   Q13324-7   (Contains a disulfide bond in positions 51-77)

Explore the universe of human proteins at neXtProt for CRHR2: NX_Q13324

Explore proteomics data for CRHR2 at MOPED

Post-translational modifications: 

  • A N-glycosylation site within the signal peptide impedes its proper cleavage and function (By similarity)1
  • Glycosylation2 at Asn41, Asn74, Asn86, Asn94
  • Modification sites at PhosphoSitePlus

  • See CRHR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001189404.1  NP_001189410.1  NP_001189411.1  NP_001189412.1  NP_001874.2  

    ENSEMBL proteins: 
     ENSP00000418722   ENSP00000401930   ENSP00000340943   ENSP00000401241   ENSP00000416620  
     ENSP00000344304   ENSP00000426498  
    Reactome Protein details: Q13324

    CRHR2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CRHR2 Protein
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    OriGene Protein Over-expression Lysate for CRHR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CRHR2
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    Novus Biologicals CRHR2 Proteins
    Novus Biologicals CRHR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRHR2

    CRHR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CRHR2
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    Novus Biologicals CRHR2 Antibodies
    Abcam antibodies for CRHR2
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    ThermoFisher Antibodies for CRHR2
    LSBio Antibodies in human, mouse, rat for CRHR2

    CRHR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript CRHR2-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for CRHR2
    Cloud-Clone Corp. CLIAs for CRHR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CRHR: GPCR / Class B : Corticotropin-releasing factor receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CRF2 receptor
    Corticotropin-releasing factor receptors

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003051 GPCR_2_CRF_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q13324

    ProtoNet protein and cluster: Q13324

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003051 Corticotropin releasing factor receptor signature
    IPB003053 Corticotropin releasing factor type 2 receptor signature


    UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
    Domain: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape.
    Transmembrane helix 7 assumes a sharply kinked structure (By similarity)
    Domain: The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It
    is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579)
    Similarity: Belongs to the G-protein coupled receptor 2 family


    CRHR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRFR2_HUMAN, Q13324
    Function: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has
    high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine
    nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the
    activation of adenylate cyclase, leading to increased intracellular cAMP levels

         Genatlas biochemistry entry for CRHR2:
    corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI11329063
    GO:0015056corticotrophin-releasing factor receptor activity IEA--
         
    CRHR2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crhr2):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  immune system  vision/eye 

    CRHR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRHR2: Crhr2tm1Klee Crhr2tm1Jsp Crhr2tm1Mpsp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRHR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRHR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRHR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRHR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRHR2:
    hsa-mir-335-5p (MIRT017454)

    Block miRNA regulation of human, mouse, rat CRHR2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CRHR2:
    hsa-miR-299-5p hsa-miR-92a-1* hsa-miR-4328 hsa-miR-558 hsa-miR-2278 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidCRHR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRHR2
    Predesigned siRNA for gene silencing in human, mouse, rat CRHR2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CRHR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CRHR2 (NM_001883)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRFR2_HUMAN, Q13324: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    golgi apparatus2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8536644
    GO:0009986cell surface IEA--

    CRHR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRHR2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    cAMP Pathway0.77
    4G-Beta Gamma Signaling
    CRHR Pathway0.44
    5ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRHR2
        cAMP Pathway
    CRHR Pathway
    Activation of cAMP-Dependent PKA

    2 BioSystems Pathways for CRHR2
        GPCRs, Class B Secretin-like
    Corticotropin-releasing hormone

    2 Reactome Pathways for CRHR2
        G alpha (s) signalling events
    Class B/2 (Secretin family receptors)

    1 PharmGKB Pathway for CRHR2
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for CRHR2):
        Neuroactive ligand-receptor interaction


    CRHR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRHR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRHR2

    4 Interacting proteins for CRHR2 (Q133243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893I2D: score=3 
    CRHP068503I2D: score=2 
    UCN2Q96RP33I2D: score=1 
    UCN3Q969E33I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8536644
    GO:0016525negative regulation of angiogenesis IEA--
    GO:0043950positive regulation of cAMP-mediated signaling IEA--

    CRHR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CRHR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    K 41498Highly selective and potent CRF2 antagonist[434938-41-7]
    Astressin 2BSelective CRF2 antagonist[681260-70-8]
    Antisauvagine-30 Potent, selective and competitive CRF2 antagonist [220673-95-0]

    Selected IUPHAR Ligands for CRHR2 (CRF2 receptor) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]urocortin 1 (mouse, rat)
    AgonistFull agonist109918582
    [125I]antisauvagine
    AntagonistAntagonist9.911123370
    [125I]sauvagine (frog)
    AgonistFull agonist9.6 - 9.811123370 15450949
    [125I]astressin
    AntagonistAntagonist9.6 - 9.711123370 15450949
    antisauvagine
    AntagonistAntagonist8.8 - 9.611123370
    urocortin 1
    AgonistFull agonist9 - 9.611123370 15450949
    urocortin 1
    AgonistFull agonist8.6 - 9.411123370
    sauvagine
    AgonistFull agonist7.6 - 9.311123370 15450949
    K41498
    AntagonistAntagonist9.212110614
    astressin
    AntagonistAntagonist8.8 - 8.911123370

    Selected Novoseek inferred chemical compound relationships for CRHR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 94.4 21 15634020 (3), 15808919 (2), 9326293 (1), 15192151 (1) (see all 10)
    astressin 92.3 6 19703147 (1), 19628576 (1), 16920976 (1), 18052377 (1)
    antalarmin 80.9 1 18484196 (1)
    acth 27.8 3 10822340 (2), 15165722 (1)
    adenylate 18.2 1 16888152 (1)
    cyclic amp 5.17 1 10428081 (1)
    calcium 0 1 17004937 (1)
    tyrosine 0 4 17194738 (2), 15634020 (1)
    proline 0 2 15189041 (1), 15634020 (1)
    histidine 0 1 15634020 (1)

    2 PharmGKB related drug/compound annotations for CRHR2 gene    About this table
    Drug/compound PharmGKB Annotation
    salbutamolCA  
    selective beta-2-adrenoreceptor agonistsCA  



    CRHR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRHR2 gene (5 alternative transcripts): 
    NM_001202475.1  NM_001202481.1  NM_001202482.1  NM_001202483.1  NM_001883.4  

    Unigene Cluster for CRHR2:

    Corticotropin releasing hormone receptor 2
    Hs.546246  [show with all ESTs]
    Unigene Representative Sequence: NM_001202481
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471646(uc010kvw.2 uc003tbn.3 uc010kvx.2 uc022abg.1 uc010kvy.2 uc003tbo.3 uc003tbp.3)
    ENST00000452278 ENST00000348438(uc010kvz.1) ENST00000445981(uc010kwa.1)
    ENST00000423776(uc003tbr.1) ENST00000462882(uc010kwb.1) ENST00000341843
    ENST00000506074
    miRNA
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    hsa-miR-299-5p hsa-miR-92a-1* hsa-miR-4328 hsa-miR-558 hsa-miR-2278 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidCRHR2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 5): CRHR2 (NM_001883)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRHR2
      QuantiTect SYBR Green Assays in human, mouse, rat CRHR2
      QuantiFast Probe-based Assays in human, mouse, rat CRHR2

    Additional mRNA sequence: 

    AF011406.1 AF019381.1 AF361106.1 AK313661.1 AY449734.1 BC096830.1 EU012439.1 EU012441.1 
    EU012443.1 FJ200484.1 U34587.1 Y10151.1 Y10152.1 Y10153.1 

    4 DOTS entries:

    DT.92390486  DT.102826566  DT.454252  DT.40223599 

    Selected AceView cDNA sequences (see all 28):

    CR617239 CA389998 Y10153 Y10151 AF019381 AF361107 AF361106 AF361108 
    AY449734 AF011406 Y10152 CD613209 CD613221 U34587 CF147819 CD613223 
    AL536395 CD613207 CD613229 CD613219 CD613228 CD613212 NM_001883 CD613224 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                -     -     -     -     -     -     -     -     -     -     -                                                               
    SP2:                                                                    -     -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                            -                                                                                                               
    SP5:                                -     -     -                       -     -     -     -     -                                                               

    ExUns: 14 ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CRHR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CRHR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCAGTGA
    CRHR2 Expression
    About this image


    CRHR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Septum   
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    CRHR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRHR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546246
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRHR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRHR2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CRHR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crhr21 , 5 corticotropin releasing hormone receptor 21, 5 88.24(n)1
    92.57(a)1
      6 (27.33 cM)5
    129221  NM_009953.31  NP_034083.21 
     550900495 
    chicken
    (Gallus gallus)
    Aves CRHR21 corticotropin releasing hormone receptor 2 77.33(n)
    88.71(a)
      395105  NM_204454.1  NP_989785.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRHR26
    corticotropin releasing hormone receptor 2
    78(a)
    1 ↔ 1
    6(1444869-1629025)
    African clawed frog
    (Xenopus laevis)
    Amphibia crhr2-A2 corticotropin releasing hormone receptor 2 78.44(n)    Y14037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003350051 corticotropin-releasing factor receptor 2-like 72.95(n)
    81.14(a)
      100335005  XM_002667848.3  XP_002667894.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123703
    Dh44-R11
    G-protein coupled receptor protein
    signaling pathway more3
    Diuretic hormone 44 receptor 11
    40(a)
    (best of 3)3
    53.08(n)1
    41.04(a)1
      49A93
    366011  NM_137116.21  NP_610960.11 


    ENSEMBL Gene Tree for CRHR2 (if available)
    TreeFam Gene Tree for CRHR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRHR2 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  VIPR12  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for CRHR2 using alignment to 5 protein entries:     CRFR2_HUMAN (see all proteins):
    CRHR1    SCTR    VIPR1    CALCR    CALCRL    VIPR2
    GIPR    GLP2R    PTH1R    GCGR    ADCYAP1R1    GHRHR
    GLP1R

    CRHR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CRHR2 (see all 1016)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573819311,2
    C,F--30669601(+) ATGAAG/ACTACA 5 -- ds50013Minor allele frequency- A:0.18WA 122
    rs1899517481,2
    --30669902(+) GGTCAG/TGTGTT 5 -- ds50010--------
    rs1448169291,2
    --30669967(+) ATGTAC/TTTTAA 5 -- ut310--------
    rs1811735661,2
    --30670092(+) AAGACA/GGGATA 5 -- ut310--------
    rs772840671,2
    C,F--30670198(+) GGCTCC/TGCTGC 5 -- ut312Minor allele frequency- T:0.10CSA WA 120
    rs1851369361,2
    --30670215(+) ACAGGA/GACGGA 5 -- ut310--------
    rs132442641,2
    C,F,H--30670244(+) CCCTGG/ATGGTC 5 -- ut3110Minor allele frequency- A:0.01NS EA NA 986
    rs414072471,2
    C,F--30670251(+) GGTCAA/GCTGAG 5 -- ut311Minor allele frequency- G:0.04WA 118
    rs2011649001,2
    --30670309(+) ACAGG-/CCCCTG 5 -- ut310--------
    rs37354301,2
    C,F,H--30670391(-) ACCAGG/ACTAAT 5 -- ut3111Minor allele frequency- A:0.14EA NS NA 2910

    HapMap Linkage Disequilibrium report for CRHR2 (30691559 - 30739745 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CRHR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734201CNV Deletion23290073
    nsv436557CNV Deletion17901297
    esv1664845CNV Insertion17803354
    nsv830938CNV Gain17160897
    nsv527038CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRHR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRHR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602034    OMIM disorders: --

    Selected diseases for CRHR2 (see all 30):    
    About MalaCards
    autonomic dysfunction    eating disorder    bacterial vaginosis    anxiety disorder
    drug dependence    irritable bowel syndrome    mood disorder    panic disorder
    chronic fatigue syndrome    pheochromocytoma    anorexia nervosa    major depressive disorder
    obesity    bipolar disorder    choroiditis    asthma
    renal cell carcinoma    hepatitis c    hepatocellular carcinoma    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for CRHR2:
    Kidney failure

    CRHR2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CRHR2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anxiety disorders 40.5 1 18384079 (1)
    mood disorders 23.6 3 16611089 (1), 11857585 (1), 15102917 (1)
    colitis 11.3 4 17412781 (2)
    genetic susceptibility 8.4 3 18838498 (1), 17532191 (1), 16691126 (1)
    eating disorders 1.92 2 11526468 (1), 16634704 (1)
    inflammation 0.715 5 18670748 (1), 16054139 (1)
    atrophy 0 2 15808919 (1), 16476507 (1)
    tachycardia 0 1 12786991 (1)
    pheochromocytoma 0 1 17194738 (1)
    tumors 0 16 19433256 (3), 19968503 (1), 19058138 (1)

    Genetic Association Database (GAD): CRHR2
    Human Genome Epidemiology (HuGE) Navigator: CRHR2 (33 documents)

    Export disorders for CRHR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRHR2 gene, integrated from 10 sources (see all 221):
    (articles sorted by number of sources associating them with CRHR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. (PubMed id 8536644)1, 2, 3 Liaw C.W....de Souza E.B. (Endocrinology 1996)
    2. Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits. (PubMed id 16884458)1, 4, 9 Tochigi M....Sasaki T. (Psychiatry Clin. Neurosci. 2006)
    3. An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. (PubMed id 19813023)1, 4, 9 Gu X....Gao C. (Hum. Genet. 2010)
    4. Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (PubMed id 11857585)1, 4, 9 Villafuerte S.M....Claes S. (Am. J. Med. Genet. 2002)
    5. A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth. (PubMed id 20164545)1, 4, 9 Schmid M....Egarter C. (Dis. Markers 2010)
    6. Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder. (PubMed id 17532191)1, 4, 9 De Luca V....Kennedy J.L. (Eur. Psychiatry 2007)
    7. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)1, 4, 9 Challis B.G....O'Rahilly S. (Int. J. Obes. Relat. Metab. Disord. 2004)
    8. Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder. (PubMed id 16691126)1, 4, 9 Tharmalingam S....Kennedy J.L. (Psychiatr. Genet. 2006)
    9. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. (PubMed id 18408560)1, 4, 9 Poon A.H....Weiss S.T. (Pharmacogenet. Genomics 2008)
    10. Association of HPA axis genes with suicidal behaviour in schizophrenia. (PubMed id 18838498)1, 4, 9 De Luca V....Kennedy J.L. (J. Psychopharmacol. (Oxford) 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1395 HGNC: 2358 AceView: CRHR2 Ensembl:ENSG00000106113 euGenes: HUgn1395
    ECgene: CRHR2 Kegg: 1395 H-InvDB: CRHR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRHR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CRHR2 gene:
    Search GeneIP for patents involving CRHR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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