Aliases for CRHR2 Gene
External Ids for CRHR2 Gene
Previous GeneCards Identifiers for CRHR2 Gene
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
GeneCards Summary for CRHR2 Gene
CRHR2 (Corticotropin Releasing Hormone Receptor 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include hormone activity and corticotrophin-releasing factor receptor activity. An important paralog of this gene is VIPR2.
UniProtKB/Swiss-Prot for CRHR2 Gene
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels
The corticotropin-release factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display different tissue distribution but the pharmacological and biological properties remain unchanged. The physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).