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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRHR2 Gene

protein-coding   GIFtS: 64
GCID: GC07M030658

Corticotropin Releasing Hormone Receptor 2

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Corticotropin Releasing Hormone Receptor 21 2     CRF-R-23
CRH-R22 3     CRF-R23
CRFR22 5     CRF2R3
CRF-RB2     CRFR-23
CRF22     CRH-R-23
HM-CRF2     CRH2R3
Corticotropin-Releasing Factor Receptor 22     Corticotropin-Releasing Hormone Receptor 23
CRF2 Receptor, Beta Isoform2     

External Ids:    HGNC: 23581   Entrez Gene: 13952   Ensembl: ENSG000001061137   OMIM: 6020345   UniProtKB: Q133243   

Export aliases for CRHR2 gene to outside databases

Previous GC identifers: GC07M030334 GC07M030434 GC07M030465 GC07M030574


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRHR2 Gene:
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of
corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone
(CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays
an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune
challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.(provided
by RefSeq, Jan 2011)

GeneCards Summary for CRHR2 Gene: 
CRHR2 (corticotropin releasing hormone receptor 2) is a protein-coding gene. Diseases associated with CRHR2 include eating disorder, and anxiety disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include corticotrophin-releasing factor receptor activity and hormone activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to
urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

summary for CRHR2 Gene:
The corticotropin-release factor (CRF) 2 receptor is a member of the corticotropin-releasing factor family
of G-protein-coupled receptors that also includes CRF1. Three functional splice variants have been
identified for the mammalian CRF2 receptor; CRF2a, CRF2b and CRF2c. All three splice variants display
different tissue distribution but the pharmacological and biological properties remain unchanged. The
physiological functions of CRF2 receptors are currently unclear but activation of these receptors is known
to induce anxiety and hypersensitivity to stress, and increase glucagon and insulin secretion from islet
cells. The human gene encoding the CRF2 receptor is localized on chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR2 (Corticotropin releasing hormone receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRHR2 gene promoter:
         MEF-2   HTF   HNF-4alpha1   RORalpha2   MEF-2A   POU2F1   Zic1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRHR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRHR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p21-p15

CRHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHR2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030658:  view genomic region     (about GC identifiers)

Start:
30,691,559 bp from pter      End:
30,739,745 bp from pter
Size:
48,187 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 30,741,211-30,789,281     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324 (See protein sequence)
Recommended Name: Corticotropin-releasing factor receptor 2 precursor  
Size: 411 amino acids; 47688 Da
Subunit: Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for
UCN, and considerably lower affinity for CRF, UNC2 and UCN3
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for CRHR2:
3N93 (3D)        3N95 (3D)        3N96 (3D)    
Secondary accessions: O43461 Q4QRJ4 Q99431
Alternative splicing: 3 isoforms:  Q13324-1   Q13324-2   Q13324-3   

Explore the universe of human proteins at neXtProt for CRHR2: NX_Q13324

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13324

  • CRHR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (5 alternative transcripts): 
    NP_001189404.1  NP_001189410.1  NP_001189411.1  NP_001189412.1  NP_001874.2  

    ENSEMBL proteins: 
     ENSP00000418722   ENSP00000401930   ENSP00000340943   ENSP00000401241   ENSP00000416620  
     ENSP00000344304   ENSP00000426498  
    Reactome Protein details: Q13324
    Human Recombinant Protein Products for CRHR2: 
    EMD Millipore Purified and/or Recombinant CRHR2 Protein
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    Novus Biologicals CRHR2 Proteins
    Novus Biologicals CRHR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRHR2 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8536644
    GO:0009986cell surface IEA--

    CRHR2 for ontologies           About GeneDecksing



    CRHR2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for CRHR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CRHR: GPCR / Class B : Corticotropin-releasing factor receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CRF2 receptor 
    Corticotropin-releasing factor receptors

    5/6 InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003051 GPCR_2_CRF_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like

    Graphical View of Domain Structure for InterPro Entry Q13324

    ProtoNet protein and cluster: Q13324

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003051 Corticotropin releasing factor receptor signature
    IPB003053 Corticotropin releasing factor type 2 receptor signature


    UniProtKB/Swiss-Prot: CRFR2_HUMAN, Q13324
    Similarity: Belongs to the G-protein coupled receptor 2 family


    CRHR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRFR2_HUMAN, Q13324
    Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to
    urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

         Genatlas biochemistry entry for CRHR2:
    corticotropin releasing hormone receptor 2,G protein coupled,involved gut-brain

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI11329063
    GO:0015056corticotrophin-releasing factor receptor activity IEA--
         
    CRHR2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crhr2):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  hearing/vestibular/ear 
     homeostasis/metabolism  immune system  vision/eye 

    CRHR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CRHR2: Crhr2tm1Klee Crhr2tm1Jsp Crhr2tm1Mpsp

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRHR2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRHR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRHR2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRHR2 

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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHR2:
    hsa-miR-299-5p hsa-miR-92a-1* hsa-miR-4328 hsa-miR-558 hsa-miR-2278 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidCRHR2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRHR2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    cAMP Pathway0.77
    4Prostacyclin signalling through prostacyclin receptor
    Class B/2 (Secretin family receptors)0.36
    G alpha (s) signalling events0.31
    5G-Beta Gamma Signaling
    CRHR Pathway0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CRHR2
        Adenylate cyclase-activating neuropeptides

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRHR2
        cAMP Pathway
    CRHR Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for CRHR2
        GPCRs, Class B Secretin-like

    5/6        Reactome Pathways for CRHR2 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)

    1 PharmGKB Pathway for CRHR2
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for CRHR2):
        Neuroactive ligand-receptor interaction


    CRHR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRHR2

    4 Interacting proteins for CRHR2 (Q133243) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893I2D: score=3 
    CRHP068503I2D: score=2 
    UCN2Q96RP33I2D: score=1 
    UCN3Q969E33I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS8536644
    GO:0016525negative regulation of angiogenesis IEA--
    GO:0043950positive regulation of cAMP-mediated signaling IEA--

    CRHR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRHR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CRHR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    K 41498Highly selective and potent CRF2 antagonist[434938-41-7]
    Astressin 2BSelective CRF2 antagonist[681260-70-8]
    Antisauvagine-30 Potent, selective and competitive CRF2 antagonist [220673-95-0]

    10/16 IUPHAR Ligands for CRHR2 (CRF2 receptor) (see all 16)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [125I]urocortin 1 (mouse, rat)
    AgonistFull agonist109918582
    [125I]antisauvagine
    AntagonistAntagonist9.911123370
    [125I]sauvagine (frog)
    AgonistFull agonist9.6 - 9.811123370 15450949
    [125I]astressin
    AntagonistAntagonist9.6 - 9.711123370 15450949
    urocortin 1
    AgonistFull agonist9 - 9.611123370 15450949
    antisauvagine
    AntagonistAntagonist8.8 - 9.611123370
    urocortin 1
    AgonistFull agonist8.6 - 9.411123370
    sauvagine
    AgonistFull agonist7.6 - 9.311123370 15450949
    K41498
    AntagonistAntagonist9.212110614
    astressin
    AntagonistAntagonist8.8 - 8.911123370

    10/12 Novoseek inferred chemical compound relationships for CRHR2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 94.4 21 15634020 (3), 15808919 (2), 9326293 (1), 15192151 (1) (see all 10)
    astressin 92.3 6 19703147 (1), 19628576 (1), 16920976 (1), 18052377 (1)
    antalarmin 80.9 1 18484196 (1)
    acth 27.8 3 10822340 (2), 15165722 (1)
    adenylate 18.2 1 16888152 (1)
    cyclic amp 5.17 1 10428081 (1)
    calcium 0 1 17004937 (1)
    tyrosine 0 4 17194738 (2), 15634020 (1)
    proline 0 2 15189041 (1), 15634020 (1)
    histidine 0 1 15634020 (1)

    2 PharmGKB related drug/compound annotations for CRHR2 gene    About this table
    Drug/compound PharmGKB Annotation
    salbutamolCA  
    selective beta-2-adrenoreceptor agonistsCA  

    Search CenterWatch for drugs/clinical trials and news about CRHR2 / CRFR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section

    REFSEQ mRNAs for CRHR2 gene (5 alternative transcripts): 
    NM_001202475.1  NM_001202481.1  NM_001202482.1  NM_001202483.1  NM_001883.4  

    Unigene Clusters for CRHR2:

    Corticotropin releasing hormone receptor 2
    Hs.546246  [show with all ESTs], Hs.729970  [show with all ESTs]
    Unigene Representative Sequences: NM_001202481, AF361108
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471646(uc010kvw.2 uc003tbn.3 uc010kvx.2 uc022abg.1 uc010kvy.2 uc003tbo.3 uc003tbp.3)
    ENST00000452278 ENST00000348438(uc010kvz.1) ENST00000445981(uc010kwa.1)
    ENST00000423776(uc003tbr.1) ENST00000462882(uc010kwb.1) ENST00000341843
    ENST00000506074
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHR2

    Additional mRNA sequence: 

    AF361107.1 AF361108.1 

    7 DOTS entries:

    DT.92390486  DT.454252  DT.102826566  DT.121046069  DT.121046077  DT.40223599  DT.91834764 

    24/28 AceView cDNA sequences (see all 28):

    AY449734 CA389998 AF361108 AF361107 Y10153 AF011406 AF361106 CR617239 
    Y10152 Y10151 AF019381 CF147819 CD613219 CD613228 CD613223 U34587 
    CD613224 CD613212 CD613207 AL536395 CD613209 CD613229 NM_001883 CD613221 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CRHR2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^
    SP1:                                -     -     -     -     -     -     -     -     -     -     -                                                               
    SP2:                                                                    -     -     -     -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                            -                                                                                                               
    SP5:                                -     -     -                       -     -     -     -     -                                                               

    ExUns: 14 ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CRHR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRHR2 expression in normal human tissues (normalized intensities)      CRHR2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTCAGTGA
    CRHR2 Expression
    About this image


    CRHR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             gastrocnemius muscle   
     
     Choroid Plexus (Nervous System)
             Mature Choroid Plexus Cells Choroid Plexus

    Genevestigator expression for CRHR2

    SOURCE GeneReport for Unigene clusters: Hs.546246 Hs.729970
        SABiosciences Expression via Pathway-Focused PCR Arrays including CRHR2: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRHR2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRHR2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crhr21 , 5 corticotropin releasing hormone receptor 21, 5 88.48(n)1
    92.82(a)1
      6 (27.33 cM)5
    129221  NM_009953.31  NP_034083.21 
     550900495 
    chicken
    (Gallus gallus)
    Aves CRHR21 corticotropin releasing hormone receptor 2 74.84(n)
    83.82(a)
      395105  NM_204454.1  NP_989785.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRHR26
    corticotropin releasing hormone receptor 2
    78(a)
    1 ↔ 1
    6(1444869-1629025)
    African clawed frog
    (Xenopus laevis)
    Amphibia crhr2-A2 corticotropin releasing hormone receptor 2 78.44(n)    Y14037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003350051 corticotropin-releasing factor receptor 2-like 72.63(n)
    80.39(a)
      100335005  XM_002667848.2  XP_002667894.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123703
    Dh44-R11
    G-protein coupled receptor protein
    signaling pathway more3
    Diuretic hormone 44 receptor 11
    40(a)
    (best of 3)3
    52.99(n)1
    40.75(a)1
      49A93
    366011  NM_137116.21  NP_610960.11 


    ENSEMBL Gene Tree for CRHR2 (if available)
    TreeFam Gene Tree for CRHR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRHR2 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  VIPR12  CRHR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    13 SIMAP similar genes for CRHR2 using alignment to 10 protein entries:     CRFR2_HUMAN (see all proteins):
    CRHR1    SCTR    VIPR1    CALCRL    CALCR    VIPR2
    GLP2R    GIPR    PTH1R    GCGR    ADCYAP1R1    GHRHR
    GLP1R

    CRHR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1016 SNPs in CRHR2 are shown (see all 1016)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573819311,2
    C,F--30669601(+) ATGAAG/ACTACA 5 -- ds50013Minor allele frequency- A:0.18WA 122
    rs1899517481,2
    --30669902(+) GGTCAG/TGTGTT 5 -- ds50010--------
    rs1448169291,2
    --30669967(+) ATGTAC/TTTTAA 5 -- ut310--------
    rs1811735661,2
    --30670092(+) AAGACA/GGGATA 5 -- ut310--------
    rs772840671,2
    C,F--30670198(+) GGCTCC/TGCTGC 5 -- ut312Minor allele frequency- T:0.10CSA WA 120
    rs1851369361,2
    --30670215(+) ACAGGA/GACGGA 5 -- ut310--------
    rs132442641,2
    C,F,H--30670244(+) CCCTGG/ATGGTC 5 -- ut3110Minor allele frequency- A:0.01NS EA NA 986
    rs414072471,2
    C,F--30670251(+) GGTCAA/GCTGAG 5 -- ut311Minor allele frequency- G:0.04WA 118
    rs2011649001,2
    --30670309(+) ACAGG-/CCCCTG 5 -- ut310--------
    rs37354301,2
    C,F,H--30670391(-) ACCAGG/ACTAAT 5 -- ut3111Minor allele frequency- A:0.14EA NS NA 2910

    HapMap Linkage Disequilibrium report for CRHR2 (30691559 - 30739745 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CRHR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734201CNV Deletion23290073
    nsv436557CNV Deletion17901297
    esv1664845CNV Insertion17803354
    nsv830938CNV Gain17160897
    nsv527038CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602034    OMIM disorders: --

    20/26 diseases for CRHR2 (see all 26):    About MalaCards
    eating disorder    anxiety disorder    autonomic dysfunction    bacterial vaginosis
    irritable bowel syndrome    drug dependence    panic disorder    pheochromocytoma
    anorexia nervosa    mood disorder    bipolar disorder    obesity
    renal cell carcinoma    hepatitis c    asthma    schizophrenia
    hepatocellular carcinoma    ovarian cancer    alcoholism    cervicitis

    1 disease from the University of Copenhagen DISEASES database for CRHR2:
    Kidney failure

    CRHR2 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for CRHR2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anxiety disorders 40.5 1 18384079 (1)
    mood disorders 23.6 3 16611089 (1), 11857585 (1), 15102917 (1)
    colitis 11.3 4 17412781 (2)
    genetic susceptibility 8.4 3 18838498 (1), 17532191 (1), 16691126 (1)
    eating disorders 1.92 2 11526468 (1), 16634704 (1)
    inflammation 0.715 5 18670748 (1), 16054139 (1)
    atrophy 0 2 15808919 (1), 16476507 (1)
    tachycardia 0 1 12786991 (1)
    pheochromocytoma 0 1 17194738 (1)
    tumors 0 16 19433256 (3), 19968503 (1), 19058138 (1)

    Genetic Association Database (GAD): CRHR2
    Human Genome Epidemiology (HuGE) Navigator: CRHR2 (33 documents)

    Export disorders for CRHR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRHR2 gene, integrated from 9 sources (see all 216):
    (articles sorted by number of sources associating them with CRHR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid. (PubMed id 8536644)1, 2, 3 Liaw C.W....de Souza E.B. (1996)
    2. Association between corticotropin-releasing hormone receptor 2 (CRHR2) gene polymorphism and personality traits. (PubMed id 16884458)1, 4, 9 Tochigi M....Sasaki T. (2006)
    3. An intronic polymorphism in the corticotropin-releasi ng hormone receptor 2 gene increases susceptibility to HBV-related hepatocellul ar carcinoma in Chinese population. (PubMed id 19813023)1, 4, 9 Gu X....Gao C. (2010)
    4. Gene-based SNP genetic association study of the corticotropin-releasing hormone receptor-2 (CRHR2) in major depression. (PubMed id 11857585)1, 4, 9 Villafuerte S.M....Claes S. (2002)
    5. A polymorphism of the corticotropin-releasing hormone receptor 2 (CRHR2) and preterm birth. (PubMed id 20164545)1, 4, 9 Schmid M....Egarter C. (2010)
    6. Association study between the corticotropin-releasing hormone receptor 2 gene and suicidality in bipolar disorder. (PubMed id 17532191)1, 4, 9 De Luca V....Kennedy J.L. (2007)
    7. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)1, 4, 9 Challis B.G....O'Rahilly S. (2004)
    8. Lack of association between the corticotrophin-releasing hormone receptor 2 gene and panic disorder. (PubMed id 16691126)1, 4, 9 Tharmalingam S....Kennedy J.L. (2006)
    9. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. (PubMed id 18408560)1, 4, 9 Poon A.H....Weiss S.T. (2008)
    10. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PubMed id 18384079)1, 4, 9 Keck M.E....Binder E.B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1395 HGNC: 2358 AceView: CRHR2 Ensembl:ENSG00000106113 euGenes: HUgn1395
    ECgene: CRHR2 Kegg: 1395 H-InvDB: CRHR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRHR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRHR2 gene:
    Search GeneIP for patents involving CRHR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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