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CRHR1 Gene

protein-coding GIFtS: 71

GC17P041217

corticotropin releasing hormone receptor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CRHR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRF-R ^¹, ², ³
CRF1 ^¹, ², ³
CRFR ^³
CRFR1 ^², ³
CRH-R1h ^²
CRHR ^², ³, ⁵
CRHR1f ^²

Descriptions
CRH-R 1 ^³
Corticotropin-releasing hormone receptor 1 ^³
corticotropin releasing hormone receptor 1 ^²
corticotropin-releasing factor receptor ^²
corticotropin-releasing factor type 1 receptor ^²
seven transmembrane helix receptor ^²

External Ids
HGNC: 2357¹
Entrez Gene: 1394²
UniProtKB: P34998³
Ensembl: ENSG00000120088⁷

Search outside databases for aliases for CRHR1 gene

Previous GC identifers: GC17P043455 GC17P046107 GC17P043872 GC17P044337

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CRHR1:

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin

releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway.

The encoded protein is essential for the activation of signal transduction pathways that regulate

diverse physiological processes including stress, reproduction, immune response and obesity.

Alternative splicing results in multiple transcript variants.

UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998

Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding.

The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Gene Wiki entry for CRHR1 (Corticotropin_releasing_hormone_receptor_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRHR1 gene

Entrez Gene cytogenetic band: 17q12-q22 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q12-q22

CRHR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P041217: (about GC identifiers)

Start:	41,217,449 bp from pter
End:	41,268,973 bp from pter
Size:	51,525 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998 (See protein sequence)

Recommended Name: Corticotropin-releasing factor receptor 1 precursor

Size: 444 amino acids; 50719 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

3EHS (3D)

3EHU (3D)

Secondary accessions: Q13008 Q9UK64

Alternative splicing: 4 isoforms: P34998-1 P34998-2 P34998-3 P34998-4

Post-translational modifications:

C-terminal Ser or Thr residues may be phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001138618.1 NP_001138619.1 NP_001138620.1 NP_004373.2

ENSEMBL proteins:

ENSP00000340522 ENSP00000293493 ENSP00000381333 ENSP00000326060 ENSP00000239167 ENSP00000344068

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant CRHR1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CRF1)
	Human Recombinant Proteins from Abnova (CRHR1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	7692441
GO:0005887	integral to plasma membrane	TAS	10598591

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Antibodies for CRHR1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CRHR1
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for CRHR1 (CRHR-1)
	Antibodies from Abcam (CRF1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRHR1)
	Novus Biologicals Antibodies for CRHR1

Assays for CRHR1:

	Invitrogen Assays for CRHR1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P34998

ProtoNet protein and cluster: P34998

3 Blocks protein families:

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB003051 Corticotropin releasing factor receptor signature

IPB003052 Corticotropin releasing factor type 1 receptor signature

UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998

Similarity: Belongs to the G-protein coupled receptor 2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRHR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRHR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004382

Applied Biosystems Silencer® siRNAs for CRHR1

Sigma-Aldrich siRNA and siRNA Panels for CRHR1

Sigma-Aldrich shRNA Panels and shRNA for CRHR1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRHR1
		Millipore Clones for the Expression of CRHR1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145146
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145146
untagged cDNA clones in CMV expression vector (see all 4): NM_001145146

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001145146

UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998

Function: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding.

The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Genatlas biochemistry entry for CRHR1:

corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced

isoforms

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crhr1):

behavior/neurological	endocrine/exocrine gland	homeostasis/metabolism	life span-post-weaning/aging	nervous system
normal	respiratory system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015056	corticotrophin-releasing factor receptor activity	TAS	10598591

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CRHR1 (Your Favorite Gene powered by Ingenuity)

Corticotropin Releasing Hormone Signaling
Synaptic Long Term Depression

GeneDecks CRHR1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CRHR1

5/28 Interacting proteins for CRHR1 (ENSP00000293493³ P34998²) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM1	P62158²	MINT-51638
CALM2	P62158²	MINT-51638
CALM3	P62158²	MINT-51638
CRH	ENSP00000276571³	STRING (score=.999)
UCN	ENSP00000296099³	STRING (score=.998)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	7692441
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	8243652
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	TAS	7692441
GO:0007190	activation of adenylate cyclase activity	TAS	10598591
GO:0007565	female pregnancy	NAS	7585095

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CRHR1:

Antagonist

Compounds for CRHR1 available from Tocris Bioscience

Compound	Action	CAS number
CP 376395 hydrochloride	Potent and selective CRF1 antagonist	[175140-00-8]
NBI 27914 hydrochloride	Selective non-peptide CRF1 antagonist	[184241-44-9]
Stressin I	CRF1 agonist
CP 154526	Selective, non-peptide CRF1 antagonist	[157286-86-7]
Antalarmin hydrochloride	CRF1 antagonist	[220953-69-5]

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10/19 Novoseek chemical compound relationships for CRHR1 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sauvagine	95.88	39	18955489 (5), 12029097 (3), 19124613 (3), 9449637 (1) (see all 11)
antalarmin	92.45	15	17057757 (2), 17578767 (2), 10421433 (2), 17075002 (1) (see all 10)
cp154526	82.31	2	17499724 (1), 16551464 (1)
acth	61.71	8	10822340 (2), 17197073 (1), 10421433 (1), 15572653 (1) (see all 6)
cyclic amp	38.37	2	18475726 (1), 10428081 (1)
inositol triphosphate	33.88	1	17400813 (1)
ribonucleic acid	21.63	3	9467556 (1), 9814500 (1), 17294739 (1)
125i	21.22	2	9863624 (1), 10340512 (1)
gtp	13.26	1	15252011 (1)
dhea	0.88	3	12011471 (1)

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3 PharmGKB drug compound relationships for CRHR1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
desipramine hydrochloride	CO PD GN	15365580
flunisolide	CO PD GN	15128701
xenobiotics	FA	11526468

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRHR1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRHR1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004382

Sigma-Aldrich siRNA and siRNA Panels for CRHR1

Sigma-Aldrich shRNA Panels and shRNA for CRHR1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004382

REFSEQ mRNAs for CRHR1 gene (4 alternative transcripts):

NM_001145146.1 NM_001145147.1 NM_001145148.1 NM_004382.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004382

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001145146
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001145146
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001145146

Additional cDNA sequence:

AB451466.1 AF180301.1 AF369651.1 AF369652.1 AF369653.1 AF374231.1 AY429529.1 AY457172.1

BC096836.1 EU176016.1 L23332.1 L23333.1 U16273.1 X72304.1

7 DOTS entries:

DT.101981420 DT.97796783 DT.91813708 DT.102822334 DT.101976226 DT.213050 DT.95368431

24/38 AceView cDNA sequences (see all 38 ):

BX113548 AF369652 AY429529 U16273 NM_004382 BM682940 AY457172 BC037967

BM719651 L23332 BM451777 AF369651 F06999 L23333 AF180301 X72304

BM709844 BG291013 AF369653 T29535 CF147820 BM925912 F03275 AF374231

highest scoring ESTs for CRHR1:

X72304 AA328065 AF180301 AF369652 AW967020 AY457172 BM451777 BM682940 BM719651 BX113548

Unigene Cluster for CRHR1:

Corticotropin releasing hormone receptor 1

Hs.417628 [show with all ESTs]

Unigene Representative Sequence: NM_001145146

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13
SP1:													-
SP2:									-				-
SP3:									-				-														-
SP4:			-						-				-
SP5:			-						-

About this scheme

ECgene alternative splicing isoforms for CRHR1

6 Ensembl transcripts including schematic representations:

ENST00000339069 ENST00000293493 ENST00000398285 ENST00000314537 ENST00000347197 ENST00000352855

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRHR1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRHR1

¹ / ² / ³

8 probe-sets matching CRHR1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40651_s_at²^{, 3}	U95-A	1	1.00	1.00	0.72	1.28	AF039523	0.20	1.00	0.72	1
40650_r_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.74	X72304	1.00	1.00	1.00	1
208593_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004382	0.60	1.00	0.82	1
214619_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X72304	1.00	1.00	1.00	1
211897_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF180301	0.80	1.00	0.91	1
208593_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214619_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211897_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCAGAGGGA

SOURCE GeneReport for Unigene cluster: Hs.417628
Expression variation in blood from EXPOLDB for CRHR1
UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and
olfactory lobe

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRHR1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRHR1¹	--	corticotropin releasing hormone receptor 1	93.49(n) 97.83(a)	610380 XM_847872.1 XP_852965.1
chimpanzee (Pan troglodytes)	CRHR1¹	--	corticotropin releasing hormone receptor 1	99.6(n) 99.52(a)	468283 XM_001138338.1 XP_001138338.1
cow (Bos taurus)	CRHR1¹	--	corticotropin releasing hormone receptor 1	93.09(n) 96.87(a)	281716 NM_174287.1 NP_776712.1
rat (Rattus norvegicus)	Crhr1¹	--	corticotropin releasing hormone receptor 1	90.76(n) 97.11(a)	58959 NM_030999.1 NP_112261.1
mouse (Mus musculus)	Crhr1^{1, 5}	11 (62.00 cM)⁵	corticotropin releasing hormone receptor 1^{1, 5}	91.08(n)¹ 97.59(a)¹	12921¹ NM_007762.3¹ NP_031788.1¹ AB375515⁵ AF369654⁵ (see all 17)

About this table Species with no ortholog for CRHR1

ENSEMBL Gene Tree for CRHR1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CRHR1 gene

PTH2R² PTH1R² CRHR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/374 NCBI SNPs in CRHR1 are shown (see all 374 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 135)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4640231^1,2	A,C,F,H	41268567(+)	`ATTTAG/CTACCC`	1	--	ut3¹		12	EU EA WA NA	1072
	rs878886^1,2	A,C,F,H	41268271(+)	`CTGGGC/GCCTGG`	1	--	ut3¹		10	EA NA MN EU WA	832
	rs878888^1,2	A,C,F,O	41268416(+)	`CCCTCA/GCTCAG`	1	--	ut3¹		5	NA MN	404
	rs878887^1,2	C,F,H,O	41268363(+)	`GATGAC/TGCCTC`	1	--	ut3¹		5	MN NA EU	444
	rs2316765^1,2	C,F,O	41268235(+)	`GGCTGT/CCTTCT`	1	--	ut3¹		1	--	86
	rs242948^1,2	A,C,F	41269325(-)	`AGCTCA/CTGCCT`	1	--	ng3¹		4	EA NA	226
--	rs4482334^1,2	A,C,F	41268611(+)	`CCCCAT/CACCAG`	1	--	ut3¹		1	--	94
--	rs4525537^1,2	A,C,F	41268504(+)	`AACCTT/CACTGG`	1	--	ut3¹		4	NA	224
	rs16940686^1,2	C,F	41268811(+)	`ACAACG/TTGCTG`	1	--	ut3¹		4	NA	234
	rs16940681^1,2	C,F	41267940(+)	`CCAAAG/CAGCTG`	1	--	ut3¹		2	EU	232

About this table

HapMap Linkage Disequilibrium images for CRHR1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 122561

10/27 Novoseek disease relationships for CRHR1 gene (see all 27 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
supranuclear palsy progressive	48.05	2	17010515 (1), 19022385 (1)
anxiety depression	42.14	4	16290887 (1), 19120089 (1), 18801728 (1), 11526468 (1)
anxiety disorders	38.91	1	18384079 (1)
retinoblastoma	36.88	5	10806401 (1), 9166723 (1), 19098121 (1)
major depression	34.83	4	16815632 (3), 15589565 (1)
pituitary tumors	30.37	1	9876345 (1)
mood disorders	24.70	1	16611089 (1)
depressive disorder	20.27	2	17499724 (1), 15310462 (1)
pituitary adenoma	12.08	1	9745449 (1)
alcoholism	10.33	14	15992556 (5), 17344409 (2), 16550213 (1)

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3 PharmGKB disease relationships for CRHR1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Asthma	CO PD GN	15128701
Depression	CO PD GN	15365580
depression, anxity, eating disorder	FA	11526468

About this table

Human Gene Mutation Database: CRHR1
Genetic Association Database: CRHR1
Human Genome Epidemiology Navigator: CRHR1 (32 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/280 PubMed articles for CRHR1 gene (see all 280 ):

Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. (PubMed id 15365580)^{1, 3, 6, 7} Licinio J....Wong M.L. (2004)
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (PubMed id 15128701)^{1, 3, 6, 7} Tantisira K.G....Weiss S.T. (2004)
Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence. (PubMed id 15992556)^{1, 3, 6} Dahl J.P....Berrettini W.H. (2005)
Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)^{1, 3, 6} Challis B.G....O'Rahilly S. (2004)
Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. (PubMed id 11425856)^{1, 3, 4} Perrin M.H.... Vale W.W. (2001)
Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. (PubMed id 15293277)^{1, 3, 6} Pastor P....Goate A.M. (2004)
Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. (PubMed id 16113459)^{3, 6} Weiss S.T....Tantisira K.G. (2004)
No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism. (PubMed id 15203442)^{3, 6} Soyka M....Bondy B. (2004)
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. (PubMed id 11526468)^{1, 7} Hiroi N....Bornstein S.R. (2001)
A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes. (PubMed id 10598591)^{3, 4} Grammatopoulos D.K.... Hillhouse E.W. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1394	HGNC: 2357	AceView: CRHR1	Ensembl:ENSG00000120088	euGenes: HUgn1394
ECgene: CRHR1	H-InvDB: CRHR1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CRHR1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CRHR1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CRHR1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CRHR1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CRHR1		Small molecules for CRHR1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CRHR1)
	Antibodies (CRHR1)
	Chimera RNAi (CRHR1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CRF1)
	Antibodies (CRF1)

Search OriGene for CRHR1

Tocris compounds for CRHR1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CRHR1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CRHR1 Gene at Home site.
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CRHR1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for CRHR1

Summaries
for CRHR1

Genomic Location
for CRHR1

Proteins
for CRHR1

Protein Domains/
Families
for CRHR1

Gene Function
for CRHR1

Pathways & Interactions
for CRHR1

Drugs & Compounds
for CRHR1

Transcripts
for CRHR1

Expression
for CRHR1

Orthologs
for CRHR1

Paralogs
for CRHR1

SNPs/Variants
for CRHR1

Disorders & Mutations
for CRHR1

Medical News
for CRHR1

Publications
for CRHR1

Search for CRHR1

Genome Databases showing CRHR1

Other Databases showing CRHR1

Specialized Databases showing CRHR1

Licensable Technologies
for CRHR1

Services
for CRHR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRHR1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor CRHR1

Summariesfor CRHR1

Genomic Locationfor CRHR1

Proteinsfor CRHR1

Protein Domains/Familiesfor CRHR1

Gene Functionfor CRHR1

Pathways & Interactionsfor CRHR1

Drugs & Compoundsfor CRHR1

Transcriptsfor CRHR1

Expression for CRHR1

Orthologsfor CRHR1

Paralogsfor CRHR1

SNPs/Variantsfor CRHR1

Disorders & Mutationsfor CRHR1

Medical Newsfor CRHR1

Publicationsfor CRHR1

Search for CRHR1

Genome Databases showing CRHR1

Other Databases showing CRHR1

Specialized Databases showing CRHR1

Licensable Technologiesfor CRHR1

Servicesfor CRHR1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRHR1

Summaries
for CRHR1

Genomic Location
for CRHR1

Proteins
for CRHR1

Protein Domains/
Families
for CRHR1

Gene Function
for CRHR1

Pathways & Interactions
for CRHR1

Drugs & Compounds
for CRHR1

Transcripts
for CRHR1

Expression
for CRHR1

Orthologs
for CRHR1

Paralogs
for CRHR1

SNPs/Variants
for CRHR1

Disorders & Mutations
for CRHR1

Medical News
for CRHR1

Publications
for CRHR1

Licensable Technologies
for CRHR1

Services
for CRHR1