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Aliases for CRHR1 Gene

Aliases for CRHR1 Gene

  • Corticotropin Releasing Hormone Receptor 1 2 3
  • CRHR 3 4 6
  • CRF-R-1 3 4
  • CRH-R-1 3 4
  • CRF-R1 3 4
  • CRFR-1 3 4
  • CRH-R1 3 4
  • CRFR1 3 4
  • Corticotropin-Releasing Factor Type 1 Receptor 3
  • Corticotropin-Releasing Hormone Receptor 1 4
  • Corticotropin-Releasing Factor Receptor 1 3
  • Corticotropin-Releasing Factor Receptor 2
  • Seven Transmembrane Helix Receptor 3
  • CRH Receptor 1 3
  • CRHR1L 3
  • CRF-R 3
  • CRF1 3
  • CRFR 4

External Ids for CRHR1 Gene

Previous HGNC Symbols for CRHR1 Gene

  • CRHR

Previous GeneCards Identifiers for CRHR1 Gene

  • GC17P043455
  • GC17P046107
  • GC17P043872
  • GC17P044337
  • GC17P041217
  • GC17P039548
  • GC17P043699
  • GC17P043704
  • GC17P043733

Summaries for CRHR1 Gene

Entrez Gene Summary for CRHR1 Gene

  • This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for CRHR1 Gene

CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include generalized anxiety disorder and obesity. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein complex binding and corticotrophin-releasing factor receptor activity. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for CRHR1 Gene

  • G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Tocris Summary for CRHR1 Gene

  • The corticotropin-release factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland. CRF1 receptors regulate ACTH release and the stress response. The human gene encoding the CRF1 receptor is localized on chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHR1 Gene

Genomics for CRHR1 Gene

Regulatory Elements for CRHR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRHR1 Gene

Start:
45,620,344 bp from pter
End:
45,835,828 bp from pter
Size:
215,485 bases
Orientation:
Plus strand

Genomic View for CRHR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHR1 Gene

Proteins for CRHR1 Gene

  • Protein details for CRHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34998-CRFR1_HUMAN
    Recommended name:
    Corticotropin-releasing factor receptor 1
    Protein Accession:
    P34998
    Secondary Accessions:
    • B4DIE9
    • Q13008
    • Q4QRJ1
    • Q9UK64

    Protein attributes for CRHR1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50719 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding.

    Three dimensional structures from OCA and Proteopedia for CRHR1 Gene

    Alternative splice isoforms for CRHR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRHR1 Gene

Proteomics data for CRHR1 Gene at MOPED

Post-translational modifications for CRHR1 Gene

  • C-terminal Ser or Thr residues may be phosphorylated.
  • Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
  • Glycosylation at Asn38, Asn45, Asn78, Asn90, and Asn98
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CRHR1 Gene

Domains for CRHR1 Gene

Gene Families for CRHR1 Gene

HGNC:
  • CRHR :GPCR / Class B : Corticotropin-releasing factor receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P34998

UniProtKB/Swiss-Prot:

CRFR1_HUMAN :
  • P34998
Domain:
  • The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CRHR1: view

Function for CRHR1 Gene

Molecular function for CRHR1 Gene

GENATLAS Biochemistry: corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Gene Ontology (GO) - Molecular Function for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 18801728
GO:0015056 corticotrophin-releasing factor receptor activity IDA 18292205
genes like me logo Genes that share ontologies with CRHR1: view
genes like me logo Genes that share phenotypes with CRHR1: view

Animal Models for CRHR1 Gene

MGI Knock Outs for CRHR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRHR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CRHR1 Gene

Localization for CRHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHR1 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRHR1 Gene COMPARTMENTS Subcellular localization image for CRHR1 gene
Compartment Confidence
plasma membrane 5
endosome 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005771 multivesicular body IEA --
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10598591
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CRHR1: view

Pathways for CRHR1 Gene

genes like me logo Genes that share pathways with CRHR1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CRHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006955 immune response TAS 7692441
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with CRHR1: view

Compounds for CRHR1 Gene

(5) Tocris Compounds for CRHR1 Gene

Compound Action Cas Number
Antalarmin hydrochloride CRF1 antagonist [220953-69-5]
CP 154526 Selective, non-peptide CRF1 antagonist [257639-98-8]
CP 376395 hydrochloride Potent and selective CRF1 antagonist [1013933-37-3]
NBI 35965 hydrochloride Potent and selective CRF1 antagonist [603151-83-3]
Stressin I CRF1 agonist

(20) IUPHAR Ligand for CRHR1 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]sauvagine (frog) Agonist Full agonist 10
[125I]urocortin 1 (mouse, rat) Agonist Full agonist 10
urocortin 1 Agonist Full agonist 9.8
urocortin 1 Agonist Full agonist 9.8
[125I]CRF (ovine) Agonist Full agonist 9.5
urotensin 1 (fish) Agonist Full agonist 9.4
[125I]astressin Antagonist Antagonist 9.3
[125I]Tyr0-CRF (human, rat, mouse) Agonist Full agonist 9.3
sauvagine Agonist Full agonist 9.2
antalarmin Antagonist Antagonist 9
NBI27914 Antagonist Antagonist 9
CRF Agonist Full agonist 9
DMP696 Antagonist Antagonist 9
R121919 Antagonist Antagonist 9
CRF Agonist Full agonist 9
astressin Antagonist Antagonist 8.8
SSR125543A Antagonist Antagonist 8.7
alpha-helical CRF Antagonist Antagonist 7.8
CRA1000 Antagonist Antagonist 7.1
urocortin 2 Agonist Full agonist 5.4

(33) Novoseek inferred chemical compound relationships for CRHR1 Gene

Compound -log(P) Hits PubMed IDs
sauvagine 95.5 19
astressin 93.4 9
antalarmin 92 13
cp154526 81.5 2
acth 60.8 8

(6) PharmGKB related drug/compound annotations for CRHR1 Gene

genes like me logo Genes that share compounds with CRHR1: view

Transcripts for CRHR1 Gene

Unigene Clusters for CRHR1 Gene

Corticotropin releasing hormone receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRHR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for CRHR1 Gene

GeneLoc Exon Structure for
CRHR1
ECgene alternative splicing isoforms for
CRHR1

Expression for CRHR1 Gene

mRNA expression in normal human tissues for CRHR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHR1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.3), Brain - Cerebellum (7.3), and Pituitary (6.1).

SOURCE GeneReport for Unigene cluster for CRHR1 Gene Hs.417628

mRNA Expression by UniProt/SwissProt for CRHR1 Gene

P34998-CRFR1_HUMAN
Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
genes like me logo Genes that share expressions with CRHR1: view

In Situ Assay Products

No data available for Protein expression for CRHR1 Gene

Orthologs for CRHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRHR1 35
  • 99.62 (n)
  • 99.54 (a)
CRHR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRHR1 35
  • 93.09 (n)
  • 96.87 (a)
CRHR1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRHR1 35
  • 93.49 (n)
  • 97.83 (a)
CRHR1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crhr1 35
  • 91.08 (n)
  • 97.59 (a)
Crhr1 16
Crhr1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRHR1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHR1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crhr1 35
  • 90.76 (n)
  • 97.11 (a)
chicken
(Gallus gallus)
Aves CRHR1 35
  • 84.63 (n)
  • 90.18 (a)
CRHR1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRHR1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498637 35
  • 76.19 (n)
  • 84.18 (a)
zebrafish
(Danio rerio)
Actinopterygii crhr1 35
  • 78.01 (n)
  • 88.57 (a)
crhr1 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRDIH1 35
  • 54.87 (n)
  • 41.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dh44-R1 36
  • 32 (a)
ManyToMany
Dh44-R2 35
  • 51.92 (n)
  • 42.54 (a)
Dh44-R2 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C18B12.2 35
  • 43.59 (n)
  • 33.33 (a)
Species with no ortholog for CRHR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRHR1 Gene

ENSEMBL:
Gene Tree for CRHR1 (if available)
TreeFam:
Gene Tree for CRHR1 (if available)

Paralogs for CRHR1 Gene

genes like me logo Genes that share paralogs with CRHR1: view

Variants for CRHR1 Gene

Sequence variations from dbSNP and Humsavar for CRHR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs937 -- 45,834,909(+) GGGGG(-/C/G)CGCTC utr-variant-3-prime
rs3418 -- 45,646,096(-) ATGAC(A/G)GGATT intron-variant
rs81189 -- 45,817,432(+) GGTGA(C/G)CCCAG intron-variant
rs110402 -- 45,802,681(-) TGTTG(C/T)GTTAT intron-variant
rs171440 -- 45,816,121(-) GGACA(C/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRHR1 Gene

Variant ID Type Subtype PubMed ID
dgv964e1 CNV Complex 17122850
esv627 CNV CNV 17122850
dgv967e1 CNV Complex 17122850
nsv9563 CNV Gain+Loss 18304495
esv26189 CNV Gain+Loss 19812545
dgv968e1 CNV Complex 17122850
nsv833458 CNV Gain 17160897
dgv971e1 CNV Complex 17122850
nsv2066 CNV Insertion 18451855
nsv457744 CNV Gain 19166990
nsv2067 CNV Insertion 18451855
esv1593331 CNV Deletion 17803354
esv268910 CNV Insertion 20981092
esv2715975 CNV Deletion 23290073
esv2667768 CNV Deletion 23128226
esv275304 CNV Loss 21479260
dgv3180n71 CNV Loss 21882294
nsv833460 CNV Loss 17160897
nsv908307 CNV Loss 21882294

Relevant External Links for CRHR1 Gene

HapMap Linkage Disequilibrium report
CRHR1
Human Gene Mutation Database (HGMD)
CRHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHR1 Gene

Disorders for CRHR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CRHR1 Gene including...

Search for CRHR1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CRHR1 Gene

(28) Novoseek inferred disease relationships for CRHR1 Gene

Disease -log(P) Hits PubMed IDs
anxiety disorders 47 2
supranuclear palsy progressive 45.9 2
anxiety depression 44.4 4
major depression 43.4 5
retinoblastoma 34.5 3

Relevant External Links for CRHR1

Genetic Association Database (GAD)
CRHR1
Human Genome Epidemiology (HuGE) Navigator
CRHR1
genes like me logo Genes that share disorders with CRHR1: view

No data available for UniProtKB/Swiss-Prot for CRHR1 Gene

Publications for CRHR1 Gene

  1. Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. (PMID: 11425856) Perrin M.H. … Vale W.W. (J. Biol. Chem. 2001) 3 4 23
  2. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (PMID: 15128701) Tantisira K.G. … Weiss S.T. (Hum. Mol. Genet. 2004) 3 23 48
  3. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. (PMID: 15365580) Licinio J. … Wong M.L. (Mol. Psychiatry 2004) 3 23 48
  4. Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. (PMID: 17258395) Liu Z. … Li W. (Neurosci. Lett. 2007) 3 23 48
  5. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PMID: 14724656) Challis B.G. … O'Rahilly S. (Int. J. Obes. Relat. Metab. Disord. 2004) 3 23 48

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