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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRHR1 Gene

protein-coding   GIFtS: 67
GCID: GC17P043699

corticotropin releasing hormone receptor 1


(Previous symbol: CRHR)
 Explore 50 diseases affiliated with
CRHR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRHR1    

Aliases
for CRHR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Corticotropin Releasing Hormone Receptor 11 2     CRH-R12 3
CRHR1 2 3 5     CRH-R1h2
CRF-R1 2     CRHR1L2
CRF11 2     CRHR1f2
Corticotropin-Releasing Hormone Receptor 12 3     Corticotropin Releasing Hormone Receptor Variant 1e2
CRF-R-12 3     Corticotropin Releasing Hormone Receptor Variant 1g2
CRF-R12 3     Corticotropin-Releasing Factor Receptor 12
CRFR-12 3     Corticotropin-Releasing Factor Type 1 Receptor2
CRFR12 3     Seven Transmembrane Helix Receptor2
CRH-R-12 3     CRFR3

External Ids:    HGNC: 23571   Entrez Gene: 13942   Ensembl: ENSG000001200887   OMIM: 1225615   UniProtKB: P349983   
ORGUL members:         
NONCODE:n410555    

Export aliases for CRHR1 gene to outside databases

Previous GC identifers: GC17P043455 GC17P046107 GC17P043872 GC17P044337 GC17P041217 GC17P039548


Summaries
for CRHR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRHR1:
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family
that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the
activation of signal transduction pathways that regulate diverse physiological processes including stress,
reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which
represents a read-through transcript with the neighboring gene MGC57346. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
Function: Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this
receptor is mediated by G proteins which activate adenylyl cyclase

summary for CRHR1:
The corticotropin-release factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family
of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major
expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery
the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland. CRF1 receptors
regulate ACTH release and the stress response. The human gene encoding the CRF1 receptor is localized on
chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR1 (Corticotropin releasing hormone receptor 1)


Genomic Views
for CRHR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  NT_167251.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRHR1 gene promoter:
         AREB6   CREB   AP-1   ATF-2   deltaCREB   USF2   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRHR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRHR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q22   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q22

CRHR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043699:  view genomic region     (about GC identifiers)

Start:
 43,699,267 bp from pter      End:
 43,913,194 bp from pter
Size:
 213,928 bases      Orientation:
 plus strand

1 alternative location:
Chr17-,ALT_REF_LOCI_9 44,263,148-44,314,716     

Proteins
for CRHR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998 (See protein sequence)
Recommended Name: Corticotropin-releasing factor receptor 1 precursor  
Size: 444 amino acids; 50719 Da
Subunit: Interacts (via N-terminal extracellular domain) with CRF and UCN
Subcellular location: Cell membrane; Multi-pass membrane protein
4 PDB 3D structures from and Proteopedia for CRHR1:
2L27 (3D)        3EHS (3D)        3EHT (3D)        3EHU (3D)    
Secondary accessions: B4DIE9 Q13008 Q4QRJ1 Q9UK64
Alternative splicing: 5 isoforms:  P34998-1   P34998-2   P34998-3   P34998-4   P34998-5   (Does not bind to CRF with high affinity)

Explore the universe of human proteins at neXtProt for CRHR1: NX_P34998

Post-translational modifications:

  • C-terminal Ser or Thr residues may be phosphorylated1
  • Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream
    • signaling1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34998

    • CRHR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138618.1  NP_001138619.1  NP_001138620.1  NP_001243228.1  NP_004373.2  

    ENSEMBL proteins: 
     ENSP00000239167   ENSP00000326060   ENSP00000344068   ENSP00000462016   ENSP00000381333  
     ENSP00000463852   ENSP00000462553   ENSP00000463177   ENSP00000439934   ENSP00000340522  
     ENSP00000293493  
    Reactome Protein details: P34998
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CRHR1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): CRHR1
    OriGene Custom Protein Services for CRHR1 
    GenScript Custom Purified and Recombinant Proteins Services for CRHR1
    Novus Biologicals CRHR1 Proteins
    Novus Biologicals CRHR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CRHR1

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005771multivesicular body IEA--
    GO:0005802trans-Golgi network IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10598591
    GO:0016020membrane ----


    CRHR1 for ontologies           About GeneDecksing



    CRHR1 Antibody Products: 
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    Novus Biologicals CRHR1 Antibodies
    Search for Antibodies for CRHR1 at Abcam  
    Uscn Antibodies for CRHR1
    ThermoFisher Antibodies for CRHR1

    Assay Products for CRHR1: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for CRHR1

    Protein Domains /
    Families
    for CRHR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRHR1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003052 GPCR_2_CRF1_rcpt
     IPR001879 GPCR_2_extracellular_dom
     IPR003051 GPCR_2_CRF_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry P34998

    ProtoNet protein and cluster: P34998

    3 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003051 Corticotropin releasing factor receptor signature
    IPB003052 Corticotropin releasing factor type 1 receptor signature


    UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for CRHR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
    Function: Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this
    receptor is mediated by G proteins which activate adenylyl cyclase

         Genatlas biochemistry entry for CRHR1:
    corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced isoforms

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): CRHR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHR1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHR1 (see all 18):
    hsa-miR-1178 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-1205 hsa-miR-449a hsa-miR-4314 hsa-miR-326 hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CRHR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHR1 (see all 7)
    OriGene shRNA RFP: CRHR1
    OriGene siRNA: CRHR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CRHR1

    Clone
    Products:             		EMD Millipore Clones for the Expression of CRHR1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRHR1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRHR1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CRHR1 (NM_004382)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR1 

    Cell Line
    Products:             		GenScript CRHR1-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for CRHR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI18801728
    GO:0015056corticotrophin-releasing factor receptor activity IEA--
    GO:0032403protein complex binding IEA--


    CRHR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CRHR1:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-outs for CRHR1: Crhr1tm1Wrst Crhr1tm2.3Jde Crhr1tm1Klee
         10 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Crhr1):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis  normal  respiratory system  vision/eye 

    CRHR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRHR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		cAMP Pathway0.77
    3Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    4G beta:gamma signalling through PLC beta
    		Class B/2 (Secretin family receptors)0.20
    		G alpha (s) signalling events0.14
    5Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
    		Glucocorticoid Pathway (HPA Axis), Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CRHR1
        Adenylate cyclase-activating neuropeptides

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CRHR1
        cAMP Pathway
    CRHR Pathway
    Activation of cAMP-Dependent PKA

    2 BioSystems Pathways for CRHR1 
        Myometrial Relaxation and Contraction Pathways
    GPCRs, Class B Secretin-like

    5/6        Reactome Pathways for CRHR1 (see all 6)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)

    1 PharmGKB Pathway for CRHR1
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CRHR1):
        Neuroactive ligand-receptor interaction
    Long-term depression


    CRHR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRHR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for CRHR1 (P349981, 2, 3 ENSP000003813334) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51638 I2D: score=4 
    CALM3P621582, 3MINT-51638 I2D: score=4 
    CALM1P621582, 3, ENSP000003494674MINT-51638 I2D: score=4 STRING: ENSP00000349467
    CRHP068501, 3, ENSP000002765714EBI-3870393,EBI-3870390 I2D: score=2 STRING: ENSP00000276571
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006950response to stress ----
    GO:0006955immune response TAS7692441
    GO:0007186G-protein coupled receptor signaling pathway TAS8243652
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS7692441


    CRHR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRHR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRHR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CRHR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 376395 hydrochloridePotent and selective CRF1 antagonist[175140-00-8]
    NBI 27914 hydrochlorideSelective non-peptide CRF1 antagonist[184241-44-9]
    SN 003Potent and selective CRF1 antagonist[197801-88-0]
    CP 154526 Selective, non-peptide CRF1 antagonist [157286-86-7]
    Antalarmin hydrochlorideCRF1 antagonist[220953-69-5]
    10/33 Novoseek chemical compound relationships for CRHR1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 95.5 39 18955489 (5), 12029097 (3), 19124613 (3), 9449637 (1) (see all 11)
    astressin 93.4 9 9449626 (2), 11425856 (1), 10612445 (1), 9612279 (1) (see all 8)
    antalarmin 92 15 17057757 (2), 17578767 (2), 10421433 (2), 17075002 (1) (see all 10)
    cp154526 81.5 2 17499724 (1), 16551464 (1)
    acth 60.8 9 10822340 (2), 17197073 (1), 10421433 (1), 19571587 (1) (see all 7)
    adenylate 43.1 7 10806401 (1), 16888152 (1), 9863624 (1), 11835994 (1) (see all 5)
    cyclic amp 36.3 2 18475726 (1), 10428081 (1)
    corticosterone 35.7 8 18571864 (2), 8913341 (1), 10421433 (1), 12973355 (1) (see all 5)
    inositol triphosphate 31.4 1 17400813 (1)
    ribonucleic acid 19.4 3 9467556 (1), 9814500 (1), 17294739 (1)

    5 PharmGKB related drug/compound annotations for CRHR1 gene
    Drug/compound PharmGKB Annotation
    budesonideCA  
    corticosteroidsCA  
    fluticasone propionateCA  
    fluticasone/salmeterolCA  
    triamcinoloneCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CRHR1 / CRFR1 

    Transcripts
    for CRHR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRHR1 gene (5 alternative transcripts): 
    NM_001145146.1  NM_001145147.1  NM_001145148.1  NM_001256299.1  NM_004382.4  

    Unigene Cluster for CRHR1:

    Corticotropin releasing hormone receptor 1
    Hs.417628  [show with all ESTs]
    Unigene Representative Sequence: AK124894
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347197(uc010daq.3) ENST00000314537(uc002ijm.3 uc010dap.3 uc002ijn.3 uc010dar.3 uc010dao.3)
    ENST00000352855 ENST00000577353(uc010das.1) ENST00000398285(uc010wjx.2 uc002ijp.3 uc021tyu.1)
    ENST00000582766(uc002ijo.1) ENST00000580955 ENST00000583888 ENST00000581479
    ENST00000580876 ENST00000535778 ENST00000339069 ENST00000293493

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHR1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHR1 (see all 18):
    hsa-miR-1178 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-1205 hsa-miR-449a hsa-miR-4314 hsa-miR-326 hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CRHR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHR1 (see all 7)
    OriGene shRNA RFP: CRHR1
    OriGene siRNA: CRHR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHR1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CRHR1 (NM_004382)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRHR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRHR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHR1

    Additional cDNA sequence: 

    AB451466.1 AF180301.1 AF369651.1 AF369652.1 AF369653.1 AF374231.1 AK124894.1 AY429529.1 
    AY457172.1 BC096836.1 EU176016.1 HM852949.1 L23332.1 L23333.1 U16273.1 X72304.1 

    7 DOTS entries:

    DT.101981420  DT.97796783  DT.102822334  DT.91813708  DT.101976226  DT.213050  DT.95368431 

    24/38 AceView cDNA sequences (see all 38):

    BX113548 AY429529 NM_004382 AF369652 BM719651 L23332 F06999 AF369651 
    BG291013 X72304 BM682940 L23333 U16273 AY457172 AF369653 BM451777 
    BC037967 BM709844 AF180301 CF147820 BM925912 T29535 F03275 AF374231 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -                                                   
    SP2:                          -           -                                                   
    SP3:                          -           -                                         -         
    SP4:        -                 -           -                                                   
    SP5:        -                 -                                                               


    ECgene alternative splicing isoforms for CRHR1

    Expression
    for CRHR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRHR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCAGAGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRHR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CRHR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRHR1

    SOURCE GeneReport for Unigene cluster: Hs.417628

    UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
    Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe

        SABiosciences Expression via Pathway-Focused PCR Arrays including CRHR1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRHR1
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    In Situ
    Assay Products:     
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    Orthologs
    for CRHR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CRHR1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CRHR11 corticotropin releasing hormone receptor 1 83.17(n)
    88.41(a)    		   374218  NM_204321.1  NP_989652.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CRHR16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 6(71539994-71577985)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Y14036.12   -- 74.08(n)    Y14036.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii crhr11 corticotropin releasing hormone receptor 1 76.26(n)
    86.35(a)    		   567940  XM_691254.2  XP_696346.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dh44-R21 Diuretic hormone 44 receptor 2 51.97(n)
    41.85(a)    		   36368  NM_165907.3  NP_725175.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea C18B12.21 Protein C18B12.2 43.77(n)
    33.62(a)    		   181598  NM_078095.2  NP_510496.1 


    ENSEMBL Gene Tree for CRHR1 (if available)
    TreeFam Gene Tree for CRHR1 (if available) 

    Paralogs
    for CRHR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRHR1 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  CRHR22  PTH1R2  VIPR12  PTH2R2  
    CALCRL2  ADCYAP1R12  SCTR2  GLP2R2  VIPR22  GIPR2  
    7 SIMAP similar genes for CRHR1 using alignment to 15 protein entries:     CRFR1_HUMAN (see all proteins):
    CRHR2    GIPR    GLP2R    VIPR1    SCTR    CALCR
    GHRHR

    CRHR1 for paralogs           About GeneDecksing



    Genomic Variants
    for CRHR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1644 NCBI SNPs in CRHR1 are shown (see all 1644)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs620570711,2
    		C,F,--39523730(+) ATGATC/GATAGT 4 -- us2k15Minor allele frequency- G:0.25NA CSA 128
    rs620570721,2
    		C,F,--39524770(+) GGCTCA/C/G/T 
                GCCGG     		4 -- us2k12NA 4
    rs126035131,2
    		C,H--39524824(+) TCCTAG/TCAGCG 4 -- us2k10--------
    rs620570731,2
    		C,F,--39525156(+) TCCTCA/C/G/T 
                TAGCC     		4 -- us2k14NA CSA 126
    rs669237591,2
    		C--39527279(+) TTTTT-/TCAGGT 4 -- int10--------
    rs671069711,2
    		C--39527788(+) TTTTT-/TCAAGA 4 -- int10--------
    rs1136945361,2
    		C,--39527841(+) GTTGGA/C/GGTGTA 4 -- int12NA 122
    rs116500921,2
    		C,H,--39527968(+) tgtatA/C/G/T 
                ttttg     		4 -- int10--------
    rs728345721,2
    		C,--39528198(+) TTAGGA/C/G/T 
                TTAAT     		4 -- int10--------
    rs733093191,2
    		C,--39528867(+) CCTGTG/AAGTGA 4 -- int13Minor allele frequency- A:0.05WA CSA 122

    HapMap Linkage Disequilibrium report for CRHR1 (43699267 - 43913194 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CRHR1
         1 Inversion: 37194
    Human Gene Mutation Database (HGMD): CRHR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRHR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CRHR1

    Disorders / Diseases
    for CRHR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRHR1 for disorders           About GeneDecksing

    OMIM gene information: 122561    OMIM disorders: --

    20/50 diseases for CRHR1 (see all 50):    About MalaCards
    supranuclear palsy    placenta accreta    obesity    patent ductus arteriosus
    progressive supranuclear palsy    bacterial vaginosis    anxiety disorder    eating disorder
    major depressive disorder    irritable bowel syndrome    pituitary adenoma    drug dependence
    anorexia nervosa    pituitary tumor    alcohol dependence    panic disorder
    acute lymphoblastic leukemia    rheumatoid arthritis    lymphoblastic leukemia    endometrial cancer

    2 diseases from the University of Copenhagen DISEASES database for CRHR1:
    Irritable bowel syndrome     Alcohol dependence

    10/28 Novoseek disease relationships for CRHR1 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anxiety disorders 47 3 18384079 (1), 19911168 (1)
    supranuclear palsy progressive 45.9 2 17010515 (1), 19022385 (1)
    anxiety depression 44.4 4 16290887 (1), 19120089 (1), 18801728 (1), 11526468 (1)
    major depression 43.4 5 16815632 (3), 15589565 (1), 19844206 (1)
    retinoblastoma 34.5 5 10806401 (1), 9166723 (1), 19098121 (1)
    mood disorders 32.6 1 16611089 (1)
    pituitary tumors 28 1 9876345 (1)
    alcoholism 18.6 15 15992556 (5), 17344409 (2), 16550213 (1), 19409922 (1)
    depressive disorder 16.9 2 17499724 (1), 15310462 (1)
    stress disorders posttraumatic 14.8 1 15269266 (1)

    Genetic Association Database (GAD): CRHR1
    Human Genome Epidemiology (HuGE) Navigator: CRHR1 (68 documents)

    Export disorders for CRHR1 gene to outside databases

    Publications
    for CRHR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRHR1 gene, integrated from 9 sources (see all 372):
    (articles sorted by number of sources associating them with CRHR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. (PubMed id 15365580)1, 4, 9 Licinio J....Wong M.L. (2004)
    2. Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence. (PubMed id 15992556)1, 4, 9 Dahl J.P....Berrettini W.H. (2005)
    3. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)1, 4, 9 Challis B.G....O'Rahilly S. (2004)
    4. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. (PubMed id 15128701)1, 4, 9 Tantisira K.G....Weiss S.T. (2004)
    5. Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor. (PubMed id 11425856)1, 2, 9 Perrin M.H.... Vale W.W. (2001)
    6. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. (PubMed id 18801728)1, 2, 9 Pioszak A.A....Xu H.E. (2008)
    7. Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity. (PubMed id 14657255)1, 2, 9 Papadopoulou N....Grammatopoulos D.K. (2004)
    8. Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. (PubMed id 15293277)1, 4, 9 Pastor P....Goate A.M. (2004)
    9. NMR structure of the first extracellular domain of co rticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high aff inity agonist. (PubMed id 20843795)1, 2 Grace C.R....Riek R. (2010)
    10. Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. (PubMed id 16113459)1, 4 Weiss S.T....Tantisira K.G. (2004)

    External Searches for CRHR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRHR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1394 HGNC: 2357 AceView: CRHR1 Ensembl:ENSG00000120088 euGenes: HUgn1394
    ECgene: CRHR1 Kegg: 1394 H-InvDB: CRHR1

    Other Databases showing CRHR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRHR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRHR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CRHR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRHR1 gene:
    Search GeneIP for patents involving CRHR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CRHR1 gene

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    Advanced Cell Diagnostics
    About This Section

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