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CRHR1 Gene

protein-coding   GIFtS: 66
GCID: GC17P043733

Corticotropin Releasing Hormone Receptor 1


(Previous symbol: CRHR)
  See CRHR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Corticotropin Releasing Hormone Receptor 11 2     CRF12
CRHR1 2 3 5     CRH-R1h2
Corticotropin-Releasing Hormone Receptor 12 3     CRHR1L2
CRF-R-12 3     CRHR1f2
CRF-R12 3     Corticotropin Releasing Hormone Receptor Variant 1e2
CRFR-12 3     Corticotropin Releasing Hormone Receptor Variant 1g2
CRFR12 3     Corticotropin-Releasing Factor Receptor 12
CRH-R-12 3     Corticotropin-Releasing Factor Type 1 Receptor2
CRH-R12 3     CRH Receptor 1 Variant B2
Corticotropin-Releasing Factor Receptor1     Seven Transmembrane Helix Receptor2
CRF-R2     CRFR3

External Ids:    HGNC: 23571   Entrez Gene: 13942   Ensembl: ENSG000001200887   OMIM: 1225615   UniProtKB: P349983   

Export aliases for CRHR1 gene to outside databases

Previous GC identifers: GC17P043455 GC17P046107 GC17P043872 GC17P044337 GC17P041217 GC17P039548 GC17P043699 GC17P043704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRHR1 Gene:
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone
family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential
for the activation of signal transduction pathways that regulate diverse physiological processes including
stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants,
one of which represents a read-through transcript with the neighboring gene MGC57346. (provided by RefSeq, Jan
2012)

GeneCards Summary for CRHR1 Gene:
CRHR1 (corticotropin releasing hormone receptor 1) is a protein-coding gene. Diseases associated with CRHR1 include generalized anxiety disorder, and obesity. GO annotations related to this gene include corticotrophin-releasing factor receptor activity and protein complex binding. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
Function: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high
affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine
nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the
activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the
calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal
responses to stress. Plays a role in the response to anxiogenic stimuli

summary for CRHR1 Gene:
The corticotropin-release factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family
of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major
expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery
the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland. CRF1 receptors
regulate ACTH release and the stress response. The human gene encoding the CRF1 receptor is localized on
chromosome 17 (17q12-q22).

Gene Wiki entry for CRHR1 (Corticotropin releasing hormone receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_167251.2  NT_187663.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRHR1 gene promoter:
         AREB6   CREB   AP-1   ATF-2   deltaCREB   USF2   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRHR1 promoter sequence
   Search Chromatin IP Primers for CRHR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRHR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q22   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q22

CRHR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P043733:  view genomic region     (about GC identifiers)

Start:
43,697,710 bp from pter      End:
43,913,194 bp from pter
Size:
215,485 bases      Orientation:
plus strand

2 alternative locations:
Chr17-,ALT_REF_LOCI_9 44,339,179-44,390,746      Chr17-,NT_167251 955,380-1,005,810     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998 (See protein sequence)
Recommended Name: Corticotropin-releasing factor receptor 1 precursor  
Size: 444 amino acids; 50719 Da
Subunit: Heterodimer; heterodimerizes with GPER1 (By similarity). Interacts (via N-terminal extracellular domain)
with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding
5 PDB 3D structures from and Proteopedia for CRHR1:
2L27 (3D)        3EHS (3D)        3EHT (3D)        3EHU (3D)        4K5Y (3D)    
Secondary accessions: B4DIE9 Q13008 Q4QRJ1 Q9UK64
Alternative splicing: 5 isoforms:  P34998-1   P34998-2   P34998-3   P34998-4   P34998-5   (Does not bind to CRF with high affinity)

Explore the universe of human proteins at neXtProt for CRHR1: NX_P34998

Explore proteomics data for CRHR1 at MOPED

Post-translational modifications: 

  • C-terminal Ser or Thr residues may be phosphorylated1
  • Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates
    downstream signaling1
  • Glycosylation2 at Asn38, Asn45, Asn78, Asn90, Asn98
  • Modification sites at PhosphoSitePlus

  • See CRHR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138618.1  NP_001138619.1  NP_001138620.1  NP_001243228.1  NP_004373.2  

    ENSEMBL proteins: 
     ENSP00000239167   ENSP00000326060   ENSP00000344068   ENSP00000462016   ENSP00000381333  
     ENSP00000463852   ENSP00000462553   ENSP00000463177   ENSP00000439934   ENSP00000340522  
     ENSP00000293493  
    Reactome Protein details: P34998

    CRHR1 Human Recombinant Protein Products:

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    Novus Biologicals CRHR1 Proteins
    Novus Biologicals CRHR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CRHR1

     
    Search eBioscience for Proteins for CRHR1 

     
    antibodies-online proteins for CRHR1 (4 products) 

     
    antibodies-online peptides for CRHR1

    CRHR1 Antibody Products:

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    antibodies-online antibodies for CRHR1 (83 products) 

    CRHR1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CRHR1
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    antibodies-online kits for CRHR1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CRHR: GPCR / Class B : Corticotropin-releasing factor receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CRF1 receptor
    Corticotropin-releasing factor receptors

    Selected InterPro protein domains (see all 6):
     IPR003052 GPCR_2_CRF1_rcpt
     IPR001879 GPCR_2_extracellular_dom
     IPR003051 GPCR_2_CRF_rcpt
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry P34998

    ProtoNet protein and cluster: P34998

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003051 Corticotropin releasing factor receptor signature
    IPB003052 Corticotropin releasing factor type 1 receptor signature


    UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
    Domain: The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape.
    Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site,
    far from the presumed binding site for the physiological peptide ligand
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Find genes that share domains with CRHR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRFR1_HUMAN, P34998
    Function: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high
    affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine
    nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the
    activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the
    calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal
    responses to stress. Plays a role in the response to anxiogenic stimuli

         Genatlas biochemistry entry for CRHR1:
    corticotropin releasing hormone receptor 1,G protein coupled,with three alternatively spliced isoforms

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI18801728
    GO:0015056corticotrophin-releasing factor receptor activity IDA18292205
         
    Find genes that share ontologies with CRHR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRHR1:
     Decreased Salmonella enterica  

         10 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Crhr1):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis  normal  respiratory system  vision/eye 

    Find genes that share phenotypes with CRHR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CRHR1: Crhr1tm1Wrst Crhr1tm2.3Jde Crhr1tm1Klee

       genOway: Develop your customized and physiologically relevant rodent model for CRHR1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CRHR1 (see all 18):
    hsa-miR-1178 hsa-miR-330-5p hsa-miR-218-1* hsa-miR-1205 hsa-miR-449a hsa-miR-4314 hsa-miR-326 hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmidCRHR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRHR1
    Predesigned siRNA for gene silencing in human, mouse, rat CRHR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRHR1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CRHR1 (NM_004382)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRFR1_HUMAN, P34998: Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes
    endocytosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome2
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005771multivesicular body IEA--
    GO:0005802trans-Golgi network IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10598591
    GO:0016020membrane ----

    Find genes that share ontologies with CRHR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRHR1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    cAMP Pathway0.77
    4G-Beta Gamma Signaling
    CRHR Pathway0.44
    5Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    Find genes that share SuperPaths with CRHR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CRHR1
        cAMP Pathway
    CRHR Pathway
    Activation of cAMP-Dependent PKA

    3 BioSystems Pathways for CRHR1
        Myometrial Relaxation and Contraction Pathways
    GPCRs, Class B Secretin-like
    Corticotropin-releasing hormone

    2 Reactome Pathways for CRHR1
        G alpha (s) signalling events
    Class B/2 (Secretin family receptors)

    1 PharmGKB Pathway for CRHR1
        Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CRHR1):
        Neuroactive ligand-receptor interaction
    Long-term depression

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRHR1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRHR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CRHR1 (P349981, 2, 3 ENSP000003813334) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51638 I2D: score=4 
    CALM3P621582, 3MINT-51638 I2D: score=4 
    CALM1P621582, 3, ENSP000003494674MINT-51638 I2D: score=4 STRING: ENSP00000349467
    CRHP068501, 3, ENSP000002765714EBI-3870393,EBI-3870390 I2D: score=2 STRING: ENSP00000276571
    GNAQP501483, ENSP000002865484I2D: score=3 STRING: ENSP00000286548
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006955immune response TAS7692441
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with CRHR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CRHR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 376395 hydrochloridePotent and selective CRF1 antagonist[175140-00-8]
    NBI 27914 hydrochlorideSelective non-peptide CRF1 antagonist[184241-44-9]
    NBI 35965 hydrochloridePotent and selective CRF1 antagonist[603151-83-3]
    Antalarmin hydrochlorideCRF1 antagonist[220953-69-5]
    CP 154526 Selective, non-peptide CRF1 antagonist [157286-86-7]

    Selected IUPHAR Ligands for CRHR1 (CRF1 receptor) (see all 20)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]sauvagine (frog)
    AgonistFull agonist9.8 - 1011123370 15450949
    [125I]urocortin 1 (mouse, rat)
    AgonistFull agonist109918582
    urocortin 1
    AgonistFull agonist8.3 - 9.87477349 9918582 11123370 8612563 11416224
    urocortin 1
    AgonistFull agonist8.6 - 9.58612563 15450949 11123370
    [125I]CRF (ovine)
    AgonistFull agonist9.57692441 9326293
    urotensin 1 (fish)
    AgonistFull agonist7.8 - 9.411123370 7477349
    [125I]astressin
    AntagonistAntagonist9.2 - 9.311123370 15450949
    [125I]Tyr0-CRF (human, rat, mouse)
    AgonistFull agonist9.311123370
    sauvagine
    AgonistFull agonist6.7 - 9.29918582 9326293 11123370 8612563 15450949 7477349
    antalarmin
    AntagonistAntagonist8.3 - 98940412

    Selected Novoseek inferred chemical compound relationships for CRHR1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 95.5 39 18955489 (5), 12029097 (3), 19124613 (3), 9449637 (1) (see all 11)
    astressin 93.4 9 9449626 (2), 11425856 (1), 10612445 (1), 9612279 (1) (see all 8)
    antalarmin 92 15 17057757 (2), 17578767 (2), 10421433 (2), 17075002 (1) (see all 10)
    cp154526 81.5 2 17499724 (1), 16551464 (1)
    acth 60.8 9 10822340 (2), 17197073 (1), 10421433 (1), 19571587 (1) (see all 7)
    adenylate 43.1 7 10806401 (1), 16888152 (1), 9863624 (1), 11835994 (1) (see all 5)
    cyclic amp 36.3 2 18475726 (1), 10428081 (1)
    corticosterone 35.7 8 18571864 (2), 8913341 (1), 10421433 (1), 12973355 (1) (see all 5)
    inositol triphosphate 31.4 1 17400813 (1)
    ribonucleic acid 19.4 3 9467556 (1), 9814500 (1), 17294739 (1)

    6 PharmGKB related drug/compound annotations for CRHR1 gene    About this table
    Drug/compound PharmGKB Annotation
    budesonideCA  
    corticosteroidsCA  
    fluoxetineCA  
    fluticasone propionateCA  
    fluticasone/salmeterolCA  
    triamcinoloneCA  



    Find genes that share compounds with CRHR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRHR1 gene (5 alternative transcripts): 
    NM_001145146.1  NM_001145147.1  NM_001145148.1  NM_001256299.1  NM_004382.4  

    Unigene Cluster for CRHR1:

    Corticotropin releasing hormone receptor 1
    Hs.417628  [show with all ESTs]
    Unigene Representative Sequence: AK124894
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347197(uc010daq.3) ENST00000314537(uc002ijm.3 uc010dap.3 uc002ijn.3 uc010dar.3 uc010dao.3)
    ENST00000352855 ENST00000577353(uc010das.1) ENST00000398285(uc010wjx.2 uc002ijp.3 uc021tyu.1)
    ENST00000582766(uc002ijo.1) ENST00000580955 ENST00000583888 ENST00000581479
    ENST00000580876 ENST00000535778 ENST00000339069 ENST00000293493
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    Additional mRNA sequence: 

    AB451466.1 AF180301.1 AF369651.1 AF369652.1 AF369653.1 AF374231.1 AK124894.1 AY429529.1 
    AY457172.1 BC096836.1 EU176016.1 FJ200483.1 HM852949.1 L23332.1 L23333.1 U16273.1 
    X72304.1 

    7 DOTS entries:

    DT.101981420  DT.97796783  DT.102822334  DT.91813708  DT.101976226  DT.213050  DT.95368431 

    Selected AceView cDNA sequences (see all 38):

    AF369652 BG291013 AY457172 BC037967 F06999 BM451777 X72304 BM719651 
    AF369651 BM682940 AF369653 U16273 NM_004382 AY429529 AF180301 L23332 
    L23333 BX113548 BM709844 CF147820 BM925912 AF374231 T29535 F03275 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRHR1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -                                                   
    SP2:                          -           -                                                   
    SP3:                          -           -                                         -         
    SP4:        -                 -           -                                                   
    SP5:        -                 -                                                               


    ECgene alternative splicing isoforms for CRHR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRHR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGAGGGA
    CRHR1 Expression
    About this image


    CRHR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Septum   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Neurons
             AII Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer
    CRHR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRHR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.417628

    UniProtKB/Swiss-Prot: CRFR1_HUMAN, P34998
    Tissue specificity: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRHR1: 
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              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRHR1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crhr11 , 5 corticotropin releasing hormone receptor 11, 5 91.08(n)1
    97.59(a)1
      11 (67.77 cM)5
    129211  NM_007762.41  NP_031788.11 
     1041328555 
    chicken
    (Gallus gallus)
    Aves CRHR11 corticotropin releasing hormone receptor 1 84.63(n)
    90.18(a)
      374218  NM_204321.1  NP_989652.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRHR16
    corticotropin releasing hormone receptor 1
    86(a)
    1 ↔ 1
    6(71463186-71577985)
    African clawed frog
    (Xenopus laevis)
    Amphibia Y14036.12   -- 74.08(n)    Y14036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crhr11 corticotropin releasing hormone receptor 1 78.01(n)
    88.57(a)
      567940  XM_691254.3  XP_696346.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dh44-R21 Diuretic hormone 44 receptor 2 51.92(n)
    42.54(a)
      36368  NM_165907.3  NP_725175.3 
    worm
    (Caenorhabditis elegans)
    Secernentea C18B12.21 C18B12.2 43.59(n)
    33.33(a)
      181598  NM_078095.3  NP_510496.1 


    ENSEMBL Gene Tree for CRHR1 (if available)
    TreeFam Gene Tree for CRHR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRHR1 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  PTH2R2  
    CALCRL2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    7 SIMAP similar genes for CRHR1 using alignment to 13 protein entries:     CRFR1_HUMAN (see all proteins):
    GIPR    CRHR2    GLP2R    SCTR    GHRHR    CALCR
    VIPR1

    Find genes that share paralogs with CRHR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRHR1 (see all 4023)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562008391,2
    C--39415704(+) AGCCT-/C/GTCTTC 1 -- int12NA CSA 4
    rs1142650761,2
    C,F--39533730(-) CCCAAG/ATCTTT 5 -- int11Minor allele frequency- A:0.03WA 118
    rs1145584861,2
    C,F--39536072(-) CAGCTG/AGGTGA 5 -- int11Minor allele frequency- A:0.04WA 118
    rs1854008771,2
    C--39556325(-) TTCATG/TGTTCC 5 -- int10--------
    rs679130391,2
    C--39558277(+) GGGGC-/A/TAGGAC 5 -- int10--------
    rs678066501,2
    C--39558960(+) CACTG-/C/GGGAGG 5 -- int10--------
    rs1178110371,2
    C,F--39562064(-) TCACCG/ACATAC 5 -- int11Minor allele frequency- A:0.03NA 120
    rs1124126901,2
    C--39562095(+) AGCCTC/TGTGAA 5 -- int12Minor allele frequency- T:0.10WA 120
    rs1150425131,2
    C,F--39567117(-) CCAGTC/TAGAGT 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1810153931,2
    --43724127(+) GGCAAC/TGAGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CRHR1 (43697710 - 43913194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CRHR1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667768CNV Deletion23128226
    esv2715975CNV Deletion23290073
    esv1593331CNV Deletion17803354
    esv268910CNV Insertion20981092
    nsv2066CNV Insertion18451855
    nsv2067CNV Insertion18451855
    dgv3180n71CNV Loss21882294
    nsv908307CNV Loss21882294
    esv275304CNV Loss21479260
    nsv833460CNV Loss17160897

    Human Gene Mutation Database (HGMD): CRHR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRHR1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 122561    OMIM disorders: --

    2 diseases for CRHR1:    
    About MalaCards
    generalized anxiety disorder    obesity

    3 diseases from the University of Copenhagen DISEASES database for CRHR1:
    Kidney failure     Irritable bowel syndrome     Alcohol dependence

    Find genes that share disorders with CRHR1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CRHR1 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anxiety disorders 47 3 18384079 (1), 19911168 (1)
    supranuclear palsy progressive 45.9 2 17010515 (1), 19022385 (1)
    anxiety depression 44.4 4 16290887 (1), 19120089 (1), 18801728 (1), 11526468 (1)
    major depression 43.4 5 16815632 (3), 15589565 (1), 19844206 (1)
    retinoblastoma 34.5 5 10806401 (1), 9166723 (1), 19098121 (1)
    mood disorders 32.6 1 16611089 (1)
    pituitary tumors 28 1 9876345 (1)
    alcoholism 18.6 15 15992556 (5), 17344409 (2), 16550213 (1), 19409922 (1)
    depressive disorder 16.9 2 17499724 (1), 15310462 (1)
    stress disorders posttraumatic 14.8 1 15269266 (1)

    Genetic Association Database (GAD): CRHR1
    Human Genome Epidemiology (HuGE) Navigator: CRHR1 (68 documents)

    Export disorders for CRHR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRHR1 gene, integrated from 10 sources (see all 396):
    (articles sorted by number of sources associating them with CRHR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. (PubMed id 16550213)1, 4, 9 Treutlein J....Schumann G. (Mol. Psychiatry 2006)
    2. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. (PubMed id 15365580)1, 4, 9 Licinio J....Wong M.L. (Mol. Psychiatry 2004)
    3. Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence. (PubMed id 15992556)1, 4, 9 Dahl J.P....Berrettini W.H. (J Psychiatr Res 2005)
    4. Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms. (PubMed id 20029939)1, 4, 9 Ressler K.J....Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. (PubMed id 17597588)1, 4, 9 Blomeyer D....Laucht M. (Biol. Psychiatry 2008)
    6. Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians. (PubMed id 14724656)1, 4, 9 Challis B.G....O'Rahilly S. (Int. J. Obes. Relat. Metab. Disord. 2004)
    7. 5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration. (PubMed id 19022385)1, 4, 9 Cruchaga C....Pastor P. (Neurobiol. Dis. 2009)
    8. Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension. (PubMed id 19736354)1, 4, 9 Polanczyk G....Moffitt T.E. (Arch. Gen. Psychiatry 2009)
    9. CRHR1 polymorphisms predict bone density in survivors of acute lymphoblastic leukemia. (PubMed id 18565889)1, 4, 9 Jones T.S....Relling M.V. (J. Clin. Oncol. 2008)
    10. Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. (PubMed id 18292205)1, 2, 9 Tao J....Soong T.W. (Mol. Pharmacol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1394 HGNC: 2357 AceView: CRHR1 Ensembl:ENSG00000120088 euGenes: HUgn1394
    ECgene: CRHR1 Kegg: 1394 H-InvDB: CRHR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CRHR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRHR1 gene:
    Search GeneIP for patents involving CRHR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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