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CRHBP Gene

protein-coding   GIFtS: 57
GCID: GC05P076248

Corticotropin Releasing Hormone Binding Protein

(Previous name: corticotropin releasing hormone-binding protein)
  See CRHBP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Corticotropin Releasing Hormone Binding Protein1 2     CRFBP2 3
Corticotropin Releasing Hormone-Binding Protein1 2     CRH-BP2 3
Corticotropin-Releasing Hormone-Binding Protein2 3     CRF-Binding Protein2 3
CRF-BP2 3     Corticotropin-Releasing Factor-Binding Protein2

External Ids:    HGNC: 23561   Entrez Gene: 13932   Ensembl: ENSG000001457087   OMIM: 1225595   UniProtKB: P243873   

Export aliases for CRHBP gene to outside databases

Previous GC identifers: GC05P075055 GC05P076483 GC05P076287 GC05P076332 GC05P076284 GC05P071455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRHBP Gene:
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived
peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase
throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the
placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate
pituitary-adrenal stimulation in pregnancy. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRHBP Gene:
CRHBP (corticotropin releasing hormone binding protein) is a protein-coding gene. Diseases associated with CRHBP include acth-secreting pituitary adenoma. GO annotations related to this gene include corticotropin-releasing hormone binding and peptide binding.

UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

Gene Wiki entry for CRHBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRHBP gene promoter:
         GATA-3   AP-1   ATF-2   XBP-1   LCR-F1   GATA-1   GATA-2   AREB6   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRHBP promoter sequence
   Search Chromatin IP Primers for CRHBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRHBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q

CRHBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHBP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076248:  view genomic region     (about GC identifiers)

Start:
76,248,538 bp from pter      End:
76,276,983 bp from pter
Size:
28,446 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387 (See protein sequence)
Recommended Name: Corticotropin-releasing factor-binding protein precursor  
Size: 322 amino acids; 36144 Da
Secondary accessions: Q53F32 Q6FHT5

Explore the universe of human proteins at neXtProt for CRHBP: NX_P24387

Explore proteomics data for CRHBP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn204

  • See CRHBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001873.2  
    ENSEMBL proteins: 
     ENSP00000274368   ENSP00000426097  

    CRHBP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000859 CUB_dom
     IPR008435 CRF-bd

    Graphical View of Domain Structure for InterPro Entry P24387

    ProtoNet protein and cluster: P24387

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB008435 Corticotropin-releasing factor binding


    UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
    Similarity: Belongs to the CRF-binding protein family


    Find genes that share domains with CRHBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRHBP_HUMAN, P24387
    Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

         Genatlas biochemistry entry for CRHBP:
    corticotropin releasing hormone binding protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18234674
    GO:0042277peptide binding ISS--
    GO:0051424corticotropin-releasing hormone binding IPI18234674
         
    Find genes that share ontologies with CRHBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRHBP:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crhbp):
     behavior/neurological  growth/size/body 

    Find genes that share phenotypes with CRHBP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crhbptm1Afs for CRHBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRHBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRHBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRHBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRHBP

    miRNA
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    miRTarBase miRNAs that target CRHBP:
    hsa-mir-16-5p (MIRT002477)

    Block miRNA regulation of human, mouse, rat CRHBP using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCRHBP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRHBP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRHBP_HUMAN, P24387: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton4
    endosome4
    lysosome4
    nucleus4
    vacuole4
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA1846945
    GO:0005622intracellular ISS--
    GO:0005634nucleus ISS--
    GO:0005767secondary lysosome ISS--
    GO:0005771multivesicular body ISS--

    Find genes that share ontologies with CRHBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRHBP About    
    See pathways by source

    SuperPathContained pathways About
    1Corticotropin-releasing hormone
    Corticotropin-releasing hormone


    1 BioSystems Pathway for CRHBP
        Corticotropin-releasing hormone


        Pathway & Disease-focused RT2 Profiler PCR Array including CRHBP: 
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRHBP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CRHBP (P243873 ENSP000002743684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893, ENSP000002960994I2D: score=2 STRING: ENSP00000296099
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ISS--
    GO:0002125maternal aggressive behavior IEA--
    GO:0006954inflammatory response IDA18559919
    GO:0007165signal transduction TAS7477348
    GO:0007565female pregnancy IEP1846945

    Find genes that share ontologies with CRHBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRHBP

    10 Novoseek inferred chemical compound relationships for CRHBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 89.7 22 11572971 (4), 11179597 (3), 10656997 (1), 11223175 (1) (see all 6)
    astressin 69.7 5 11179597 (1), 11572971 (1), 7479843 (1)
    acth 68.9 18 2161424 (4), 18559919 (3), 7889116 (2), 7867564 (2) (see all 9)
    prostaglandin 33.4 5 7559899 (2), 17766709 (1), 8964581 (1)
    hydrocortisone 16.7 3 11441903 (2), 7889116 (1)
    estrogen 5.58 5 9589664 (2), 15345745 (2)
    forskolin 1.69 4 8581494 (2), 9886832 (1)
    dexamethasone 0.321 5 9886832 (2), 9589664 (1), 10992187 (1)
    estradiol 0 3 15345745 (2), 10443686 (1)
    progesterone 0 1 10443686 (1)



    Find genes that share compounds with CRHBP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRHBP gene: 
    NM_001882.3  

    Unigene Cluster for CRHBP:

    Corticotropin releasing hormone binding protein
    Hs.115617  [show with all ESTs]
    Unigene Representative Sequence: NM_001882
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274368(uc010izx.3 uc003ker.3) ENST00000506501 ENST00000512446
    ENST00000514258 ENST00000503763
    miRNA
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    Block miRNA regulation of human, mouse, rat CRHBP using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCRHBP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
      QuantiFast Probe-based Assays in human, mouse, rat CRHBP

    Additional mRNA sequence: 

    AK223457.1 AK307729.1 AK311052.1 BC018038.1 CR541666.1 X58022.1 

    7 DOTS entries:

    DT.453176  DT.92423869  DT.40116422  DT.40118540  DT.95266598  DT.120828461  DT.91840282 

    Selected AceView cDNA sequences (see all 90):

    AV646516 NM_001882 BE552125 CR625877 AW451896 AI985546 CR606509 AV652073 
    CR594674 BX090453 CR592351 CF529190 CR616423 CF552795 CR622343 BM547365 
    AV651422 AA702342 AL553955 T07079 AL704202 AL547885 BI754565 BF589926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRHBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAATTT
    CRHBP Expression
    About this image


    CRHBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Inner Cell Mass (Early Embryonic Tissues)
             hIPS1
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
     
     Spleen (Hematopoietic System)
    CRHBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRHBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115617
        Pathway & Disease-focused RT2 Profiler PCR Array including CRHBP: 
              Neurotrophins & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRHBP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crhbp1 , 5 corticotropin releasing hormone binding protein1, 5 85.92(n)1
    87.27(a)1
      13 (49.50 cM)5
    129191  NM_198408.31  NP_940800.11 
     954313765 
    chicken
    (Gallus gallus)
    Aves CRHBP1 corticotropin releasing hormone binding protein 74.74(n)
    73.91(a)
      427214  XM_424801.4  XP_424801.3 
    lizard
    (Anolis carolinensis)
    Reptilia CRHBP6
    corticotropin releasing hormone binding protein
    56(a)
    1 ↔ 1
    2(14091617-14107306)
    African clawed frog
    (Xenopus laevis)
    Amphibia crhbp-A2 corticotropin releasing hormone binding protein 72.7(n)    U41858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crhbp1 corticotropin releasing hormone binding protein 65.3(n)
    63.72(a)
      445065  NM_001003459.1  NP_001003459.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG155371 CG15537 43.56(n)
    30.22(a)
      43614  NM_001104511.2  NP_001097981.1 


    ENSEMBL Gene Tree for CRHBP (if available)
    TreeFam Gene Tree for CRHBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRHBP (see all 415)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810170461,2
    --76246786(+) CTTGTC/TTTCCA 1 -- us2k10--------
    rs731239331,2
    C,F--76246811(+) GTTTTT/CCTCGA 1 -- us2k13Minor allele frequency- C:0.16WA NA 240
    rs328961,2
    C,F--76246859(-) TAAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.12NA EA 242
    rs1856893401,2
    --76246911(+) TGGTGA/CAAACT 1 -- us2k10--------
    rs785698151,2
    F--76247094(+) TGACAG/CCAGGG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs585177221,2
    C,F--76247134(+) CATGCG/ATGCAT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1884803781,2
    --76247165(+) ATGTGC/TATATG 1 -- us2k10--------
    rs348181881,2
    C,F--76247254(+) TGCCAG/CACCCC 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs125181181,2
    C,F,H--76247314(+) GGGAAC/GAGGCC 1 -- us2k12Minor allele frequency- G:0.05NA EA 240
    rs1416607071,2
    C--76247324(+) CAAGGA/GCTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRHBP (76248538 - 76276983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CRHBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830355CNV Gain17160897
    nsv823102CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRHBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CRHBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 122559    OMIM disorders: --

    1 disease for CRHBP:    
    About MalaCards
    acth-secreting pituitary adenoma


    Find genes that share disorders with CRHBP           About GenesLikeMe

    9 Novoseek inferred disease relationships for CRHBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercortisolemia 52.4 2 2169481 (1), 11441903 (1)
    cushing syndrome 48.4 9 2169481 (4), 7889116 (2), 9589664 (1)
    addisons disease 36.5 4 7889116 (2), 2169481 (2)
    preeclampsia 30.8 3 7756202 (1), 15356079 (1), 7852886 (1)
    preterm delivery 30.7 5 10992187 (2), 17636237 (2)
    hypopituitarism 30 2 7889116 (1), 2169481 (1)
    major depression 23.6 8 14573312 (4), 17599466 (2), 15996902 (1), 16482088 (1)
    inflammation 0 2 18559919 (1), 10443681 (1)
    alzheimers disease 0 1 9109532 (1)

    Genetic Association Database (GAD): CRHBP
    Human Genome Epidemiology (HuGE) Navigator: CRHBP (23 documents)

    Export disorders for CRHBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRHBP gene, integrated from 10 sources (see all 138):
    (articles sorted by number of sources associating them with CRHBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and structure of the human corticotrophin releasing factor- binding protein gene (CRHBP). (PubMed id 8198617)1, 2, 3, 9 Behan D.P.... Vale W.W. (Genomics 1993)
    2. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PubMed id 18974851)1, 4, 9 Enoch M.A....Goldman D. (PLoS ONE 2008)
    3. Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PubMed id 17599466)1, 4, 9 Van Den Eede F....Claes S.J. (Psychiatry Res 2007)
    4. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)1, 4, 9 Claes S....Van Broeckhoven C. (Biol. Psychiatry 2003)
    5. Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PubMed id 19131402)1, 4, 9 Ryckman K.K....Williams S.M. (Mol. Hum. Reprod. 2009)
    6. Assignment of disulfide bonds in corticotropin-releasing factor- binding protein. (PubMed id 8307998)1, 2, 9 Fischer W.H.... Vale W.W. (J. Biol. Chem. 1994)
    7. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. (PubMed id 1846945)1, 2, 9 Potter E....Vale W.W. (Nature 1991)
    8. Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study. (PubMed id 19723618)1, 4 Holliday K.L....McBeth J. (Ann. Rheum. Dis. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. (PubMed id 20403506)1, 4 Holliday K.L....McBeth J. (J Psychosom Res 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1393 HGNC: 2356 AceView: CRHBP Ensembl:ENSG00000145708 euGenes: HUgn1393
    ECgene: CRHBP H-InvDB: CRHBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRHBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRHBP gene:
    Search GeneIP for patents involving CRHBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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