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Aliases for CRHBP Gene

Aliases for CRHBP Gene

  • Corticotropin Releasing Hormone Binding Protein 2 3
  • Corticotropin Releasing Hormone-Binding Protein 2 3
  • Corticotropin-Releasing Hormone-Binding Protein 3 4
  • CRF-Binding Protein 3 4
  • CRF-BP 3 4
  • CRH-BP 3 4
  • CRFBP 3 4
  • Corticotropin-Releasing Factor-Binding Protein 3

External Ids for CRHBP Gene

Previous GeneCards Identifiers for CRHBP Gene

  • GC05P075055
  • GC05P076483
  • GC05P076287
  • GC05P076332
  • GC05P076284
  • GC05P071455
  • GC05P076248

Summaries for CRHBP Gene

Entrez Gene Summary for CRHBP Gene

  • Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRHBP Gene

CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Among its related pathways are Corticotropin-releasing hormone. GO annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.

UniProtKB/Swiss-Prot for CRHBP Gene

  • Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

Gene Wiki entry for CRHBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRHBP Gene

Genomics for CRHBP Gene

Regulatory Elements for CRHBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRHBP Gene

Start:
76,952,713 bp from pter
End:
76,981,158 bp from pter
Size:
28,446 bases
Orientation:
Plus strand

Genomic View for CRHBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRHBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRHBP Gene

Proteins for CRHBP Gene

  • Protein details for CRHBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24387-CRHBP_HUMAN
    Recommended name:
    Corticotropin-releasing factor-binding protein
    Protein Accession:
    P24387
    Secondary Accessions:
    • Q53F32
    • Q6FHT5

    Protein attributes for CRHBP Gene

    Size:
    322 amino acids
    Molecular mass:
    36144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRHBP Gene

Proteomics data for CRHBP Gene at MOPED

Post-translational modifications for CRHBP Gene

  • Glycosylation at Asn204
  • Modification sites at PhosphoSitePlus

Other Protein References for CRHBP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CRHBP Gene

Domains for CRHBP Gene

Protein Domains for CRHBP Gene

Suggested Antigen Peptide Sequences for CRHBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24387

UniProtKB/Swiss-Prot:

CRHBP_HUMAN :
  • P24387
Family:
  • Belongs to the CRF-binding protein family.
genes like me logo Genes that share domains with CRHBP: view

No data available for Gene Families for CRHBP Gene

Function for CRHBP Gene

Molecular function for CRHBP Gene

GENATLAS Biochemistry: corticotropin releasing hormone binding protein
UniProtKB/Swiss-Prot Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

Gene Ontology (GO) - Molecular Function for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18234674
GO:0042277 peptide binding ISS --
GO:0051424 corticotropin-releasing hormone binding IPI 18234674
genes like me logo Genes that share ontologies with CRHBP: view

Phenotypes for CRHBP Gene

MGI mutant phenotypes for CRHBP:
inferred from 1 alleles
GenomeRNAi human phenotypes for CRHBP:
genes like me logo Genes that share phenotypes with CRHBP: view

Animal Models for CRHBP Gene

MGI Knock Outs for CRHBP:

Animal Model Products

CRISPR Products

miRNA for CRHBP Gene

miRTarBase miRNAs that target CRHBP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRHBP Gene

Localization for CRHBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRHBP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRHBP Gene COMPARTMENTS Subcellular localization image for CRHBP gene
Compartment Confidence
extracellular 5
cytoskeleton 4
endosome 4
lysosome 4
nucleus 4
vacuole 4
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 1846945
GO:0005622 intracellular ISS --
GO:0005634 nucleus ISS --
GO:0005767 secondary lysosome ISS --
GO:0005771 multivesicular body ISS --
genes like me logo Genes that share ontologies with CRHBP: view

Pathways for CRHBP Gene

genes like me logo Genes that share pathways with CRHBP: view

Pathways by source for CRHBP Gene

1 BioSystems pathway for CRHBP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CRHBP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274368%0d%0a9606.ENSP00000296099%0d%0a
Selected Interacting proteins: ENSP00000274368 P24387-CRHBP_HUMAN for CRHBP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CRHBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001963 synaptic transmission, dopaminergic ISS --
GO:0002125 maternal aggressive behavior IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7477348
GO:0007565 female pregnancy IEP 1846945
genes like me logo Genes that share ontologies with CRHBP: view

Compounds for CRHBP Gene

(10) Novoseek inferred chemical compound relationships for CRHBP Gene

Compound -log(P) Hits PubMed IDs
sauvagine 89.7 11
astressin 69.7 3
acth 68.9 16
prostaglandin 33.4 4
hydrocortisone 16.7 3
genes like me logo Genes that share compounds with CRHBP: view

Transcripts for CRHBP Gene

Unigene Clusters for CRHBP Gene

Corticotropin releasing hormone binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRHBP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRHBP Gene

No ASD Table

Relevant External Links for CRHBP Gene

GeneLoc Exon Structure for
CRHBP
ECgene alternative splicing isoforms for
CRHBP

Expression for CRHBP Gene

mRNA expression in normal human tissues for CRHBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRHBP Gene

This gene is overexpressed in Brain - Hypothalamus (8.7), Liver (7.5), Kidney - Cortex (5.0), and Spleen (4.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRHBP Gene

SOURCE GeneReport for Unigene cluster for CRHBP Gene Hs.115617

genes like me logo Genes that share expressions with CRHBP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRHBP Gene

Orthologs for CRHBP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRHBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRHBP 35
  • 99.69 (n)
  • 100 (a)
CRHBP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRHBP 35
  • 88.1 (n)
  • 86.65 (a)
CRHBP 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRHBP 35
  • 88.92 (n)
  • 86.65 (a)
CRHBP 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crhbp 35
  • 85.92 (n)
  • 87.27 (a)
Crhbp 16
Crhbp 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRHBP 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRHBP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crhbp 35
  • 84.47 (n)
  • 84.78 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
CRHBP 35
  • 74.74 (n)
  • 73.91 (a)
lizard
(Anolis carolinensis)
Reptilia CRHBP 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia crhbp-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia crhbp 35
  • 68.4 (n)
  • 69.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3847 35
zebrafish
(Danio rerio)
Actinopterygii crhbp 35
  • 65.3 (n)
  • 63.72 (a)
crhbp 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000955 35
  • 44.19 (n)
  • 32.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15537 35
  • 43.56 (n)
  • 30.22 (a)
CG15537 36
  • 23 (a)
OneToOne
Species with no ortholog for CRHBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRHBP Gene

ENSEMBL:
Gene Tree for CRHBP (if available)
TreeFam:
Gene Tree for CRHBP (if available)

Paralogs for CRHBP Gene

No data available for Paralogs for CRHBP Gene

Variants for CRHBP Gene

Sequence variations from dbSNP and Humsavar for CRHBP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs13752 -- 76,969,098(+) CATGG(A/C)AGAAA utr-variant-3-prime
rs32896 -- 76,951,034(-) TAAAA(A/C)AAAAA upstream-variant-2KB
rs32897 -- 76,955,147(-) TCATC(A/G)CATAT intron-variant
rs32898 -- 76,956,550(-) CACTG(C/T)GTTAG intron-variant
rs905857 -- 76,959,510(+) GACCG(C/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRHBP Gene

Variant ID Type Subtype PubMed ID
nsv830355 CNV Gain 17160897
nsv823102 CNV Gain 20364138

Relevant External Links for CRHBP Gene

HapMap Linkage Disequilibrium report
CRHBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRHBP Gene

Disorders for CRHBP Gene

(9) Novoseek inferred disease relationships for CRHBP Gene

Disease -log(P) Hits PubMed IDs
hypercortisolemia 52.4 2
cushing syndrome 48.4 7
addisons disease 36.5 4
preeclampsia 30.8 3
preterm delivery 30.7 4

Relevant External Links for CRHBP

Genetic Association Database (GAD)
CRHBP
Human Genome Epidemiology (HuGE) Navigator
CRHBP
genes like me logo Genes that share disorders with CRHBP: view

No data available for UniProtKB/Swiss-Prot for CRHBP Gene

Publications for CRHBP Gene

  1. Cloning and structure of the human corticotrophin releasing factor- binding protein gene (CRHBP). (PMID: 8198617) Behan D.P. … Vale W.W. (Genomics 1993) 2 3 4 23
  2. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. (PMID: 1846945) Potter E. … Vale W.W. (Nature 1991) 3 4 23
  3. Assignment of disulfide bonds in corticotropin-releasing factor- binding protein. (PMID: 8307998) Fischer W.H. … Vale W.W. (J. Biol. Chem. 1994) 3 4 23
  4. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S. … Van Broeckhoven C. (Biol. Psychiatry 2003) 3 23 48
  5. Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PMID: 17599466) Van Den Eede F. … Claes S.J. (Psychiatry Res 2007) 3 23 48

Products for CRHBP Gene

Sources for CRHBP Gene

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