Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRHBP Gene

protein-coding   GIFtS: 54
GCID: GC05P076248

corticotropin releasing hormone binding protein

(Previous name: corticotropin releasing hormone-binding protein )
 Explore 22 diseases affiliated with
CRHBP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRHBP    

Aliases
for CRHBP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Corticotropin Releasing Hormone Binding Protein1 2     Corticotropin-Releasing Hormone-Binding Protein2 3
CRF-BP1 2 3     CRH-BP2 3
CRFBP1 2 3     CRF-Binding Protein2 3
Corticotropin Releasing Hormone-Binding Protein1 2     Corticotropin-Releasing Factor-Binding Protein2

External Ids:    HGNC: 23561   Entrez Gene: 13932   Ensembl: ENSG000001457087   OMIM: 1225595   UniProtKB: P243873   

Export aliases for CRHBP gene to outside databases

Previous GC identifers: GC05P075055 GC05P076483 GC05P076287 GC05P076332 GC05P076284 GC05P071455


Summaries
for CRHBP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRHBP:
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived
peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout
pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma
contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation
in pregnancy. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

Gene Wiki entry for CRHBP


Genomic Views
for CRHBP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRHBP gene promoter:
         GATA-3   AP-1   ATF-2   XBP-1   LCR-F1   GATA-1   GATA-2   AREB6   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRHBP promoter sequence
   Search SABiosciences Chromatin IP Primers for CRHBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q

CRHBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHBP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076248:  view genomic region     (about GC identifiers)

Start:
 76,248,538 bp from pter      End:
 76,276,983 bp from pter
Size:
 28,446 bases      Orientation:
 plus strand

Proteins
for CRHBP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387 (See protein sequence)
Recommended Name: Corticotropin-releasing factor-binding protein precursor  
Size: 322 amino acids; 36144 Da
Subcellular location: Secreted
Secondary accessions: Q53F32 Q6FHT5

Explore the universe of human proteins at neXtProt for CRHBP: NX_P24387

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24387

    • CRHBP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001873.2  
    ENSEMBL proteins: 
     ENSP00000274368   ENSP00000426097  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CRHBP
    OriGene Protein Over-expression Lysate: CRHBP
    OriGene Custom Protein Services for CRHBP 
    GenScript Custom Purified and Recombinant Proteins Services for CRHBP
    Novus Biologicals CRHBP Proteins
    Novus Biologicals CRHBP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CRHBP
    Uscn Proteins for CRHBP

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA1846945
    GO:0005622intracellular ISS--
    GO:0005634nucleus ISS--
    GO:0005767secondary lysosome ISS--
    GO:0005771multivesicular body ISS--


    CRHBP for ontologies           About GeneDecksing



    CRHBP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRHBP
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRHBP 
    GenScript Custom Superior Antibodies Services for CRHBP
    Novus Biologicals CRHBP Antibodies
    Search for Antibodies for CRHBP at Abcam  
    Uscn Antibodies for CRHBP
    ThermoFisher Antibodies for CRHBP

    Assay Products for CRHBP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRHBP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CRHBP

    Protein Domains /
    Families
    for CRHBP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRHBP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000859 CUB_dom
     IPR008435 CRF-bd

    Graphical View of Domain Structure for InterPro Entry P24387

    ProtoNet protein and cluster: P24387

    2 Blocks protein families:
    IPB000859 CUB domain
    IPB008435 Corticotropin-releasing factor binding


    UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
    Similarity: Belongs to the CRF-binding protein family


    Function
    for CRHBP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
    Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

         Genatlas biochemistry entry for CRHBP:
    corticotropin releasing hormone binding protein

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CRHBP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHBP
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: CRHBP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHBP (see all 7)
    OriGene shRNA RFP: CRHBP
    OriGene siRNA: CRHBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CRHBP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CRHBP (NM_001882)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CRHBP
    Search LifeMap BioReagents cell lines for CRHBP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18234674
    GO:0042277peptide binding ISS--
    GO:0051424corticotropin-releasing hormone binding IPI18234674


    CRHBP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CRHBP:
     Increased G2M DNA content 

    Animal Models:
         Mouse knock-out Crhbptm1Afs for CRHBP
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Crhbp):
     behavior/neurological  growth/size 

    CRHBP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRHBP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRHBP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CRHBP (P243873 ENSP000002743684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893, ENSP000002960994I2D: score=2 STRING: ENSP00000296099
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ISS--
    GO:0002125maternal aggressive behavior ISS--
    GO:0006954inflammatory response IDA18559919
    GO:0007165signal transduction TAS7477348
    GO:0007565female pregnancy IEP1846945


    CRHBP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRHBP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRHBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRHBP
    10 Novoseek chemical compound relationships for CRHBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 89.7 22 11572971 (4), 11179597 (3), 10656997 (1), 11223175 (1) (see all 6)
    astressin 69.7 5 11179597 (1), 11572971 (1), 7479843 (1)
    acth 68.9 18 2161424 (4), 18559919 (3), 7889116 (2), 7867564 (2) (see all 9)
    prostaglandin 33.4 5 7559899 (2), 17766709 (1), 8964581 (1)
    hydrocortisone 16.7 3 11441903 (2), 7889116 (1)
    estrogen 5.58 5 9589664 (2), 15345745 (2)
    forskolin 1.69 4 8581494 (2), 9886832 (1)
    dexamethasone 0.321 5 9886832 (2), 9589664 (1), 10992187 (1)
    estradiol 0 3 15345745 (2), 10443686 (1)
    progesterone 0 1 10443686 (1)

    Search CenterWatch for drugs/clinical trials and news about CRHBP 

    Transcripts
    for CRHBP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRHBP gene: 
    NM_001882.3  

    Unigene Cluster for CRHBP:

    Corticotropin releasing hormone binding protein
    Hs.115617  [show with all ESTs]
    Unigene Representative Sequence: NM_001882
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274368(uc010izx.3 uc003ker.3) ENST00000506501 ENST00000512446
    ENST00000514258 ENST00000503763

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CRHBP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHBP
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: CRHBP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHBP (see all 7)
    OriGene shRNA RFP: CRHBP
    OriGene siRNA: CRHBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CRHBP (NM_001882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRHBP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRHBP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP

    Additional cDNA sequence: 

    AK223457.1 AK307729.1 AK311052.1 BC018038.1 CR541666.1 X58022.1 

    7 DOTS entries:

    DT.453176  DT.92423869  DT.40116422  DT.40118540  DT.95266598  DT.120828461  DT.91840282 

    24/90 AceView cDNA sequences (see all 90):

    AV646516 CR622343 NM_001882 CR594674 CR592351 BM547365 AW451896 CF552795 
    BE552125 CR616423 CR606509 AV652073 CR625877 AV651422 CF529190 BX090453 
    AI985546 AL575674 BC018038 AA700862 AI915914 T07079 AL553955 BG700295 

    GeneLoc Exon Structure


    Expression
    for CRHBP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRHBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAAATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRHBP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CRHBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRHBP

    SOURCE GeneReport for Unigene cluster: Hs.115617
        SABiosciences Expression via Pathway-Focused PCR Array including CRHBP: 
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRHBP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRHBP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP

    Orthologs
    for CRHBP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CRHBP gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Crhbp1 , 5 corticotropin releasing hormone binding protein1, 5 85.92(n)1
    87.27(a)1    		   13 (49.50 cM)5
    129191  NM_198408.31  NP_940800.11 
     954313765 
    chicken
    (Gallus gallus)    		 Aves CRHBP1 corticotropin releasing hormone binding protein 74.74(n)
    73.91(a)    		   427214  XM_424801.3  XP_424801.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CRHBP6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 2(14092399-14107048)
    African clawed frog
    (Xenopus laevis)    		 Amphibia crhbp-A2 corticotropin releasing hormone binding protein 72.7(n)    U41858.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii crhbp1 corticotropin releasing hormone binding protein 65.3(n)
    63.72(a)    		   445065  NM_001003459.1  NP_001003459.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG155371 CG15537 44(n)
    30.22(a)    		   43614  NM_001104511.2  NP_001097981.1 


    ENSEMBL Gene Tree for CRHBP (if available)
    TreeFam Gene Tree for CRHBP (if available) 

    Paralogs
    for CRHBP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CRHBP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/340 NCBI SNPs in CRHBP are shown (see all 340)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1810170461,2
    		--76246786(+) CTTGTC/TTTCCA 1 -- us2k10--------
    rs731239331,2
    		C,--76246811(+) GTTTTT/CCTCGA 1 -- us2k13Minor allele frequency- C:0.16WA NA 240
    rs328961,2
    		C,--76246859(-) TAAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.12NA EA 242
    rs1856893401,2
    		--76246911(+) TGGTGA/CAAACT 1 -- us2k10--------
    rs785698151,2
    		--76247094(+) TGACAG/CCAGGG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs585177221,2
    		C,--76247134(+) CATGCG/ATGCAT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1884803781,2
    		--76247165(+) ATGTGC/TATATG 1 -- us2k10--------
    rs348181881,2
    		F,--76247254(+) TGCCAG/CACCCC 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs125181181,2
    		C,F,H,--76247314(+) GGGAAC/GAGGCC 1 -- us2k12Minor allele frequency- G:0.05NA EA 240
    rs1416607071,2
    		--76247324(+) CAAGGA/GCTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRHBP (76248538 - 76276983 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CRHBP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRHBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CRHBP

    Disorders / Diseases
    for CRHBP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRHBP for disorders           About GeneDecksing

    OMIM gene information: 122559    OMIM disorders: --

    20/22 diseases for CRHBP (see all 22):    About MalaCards
    acth-secreting pituitary adenoma    pre-eclampsia    bacterial vaginosis    cushing's syndrome
    major depressive disorder    pituitary adenoma    addison's disease    klebsiella
    hypopituitarism    eclampsia    bipolar disorder    alzheimer's disease
    adenoma    pneumonia    seizures    peritonitis
    obesity    hypertension    cervicitis    schizophrenia

    9 Novoseek disease relationships for CRHBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercortisolemia 52.4 2 2169481 (1), 11441903 (1)
    cushing syndrome 48.4 9 2169481 (4), 7889116 (2), 9589664 (1)
    addisons disease 36.5 4 7889116 (2), 2169481 (2)
    preeclampsia 30.8 3 7756202 (1), 15356079 (1), 7852886 (1)
    preterm delivery 30.7 5 10992187 (2), 17636237 (2)
    hypopituitarism 30 2 7889116 (1), 2169481 (1)
    major depression 23.6 8 14573312 (4), 17599466 (2), 15996902 (1), 16482088 (1)
    inflammation 0 2 18559919 (1), 10443681 (1)
    alzheimers disease 0 1 9109532 (1)

    Genetic Association Database (GAD): CRHBP
    Human Genome Epidemiology (HuGE) Navigator: CRHBP (23 documents)

    Export disorders for CRHBP gene to outside databases

    Publications
    for CRHBP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRHBP gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with CRHBP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and structure of the human corticotrophin releasing factor- binding protein gene (CRHBP). (PubMed id 8198617)1, 2, 3, 9 Behan D.P.... Vale W.W. (1993)
    2. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)1, 4, 9 Claes S....Van Broeckhoven C. (2003)
    3. Assignment of disulfide bonds in corticotropin-releasing factor- binding protein. (PubMed id 8307998)1, 2, 9 Fischer W.H.... Vale W.W. (1994)
    4. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. (PubMed id 1846945)1, 2, 9 Potter E....Vale W.W. (1991)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1. (PubMed id 18234674)1, 9 Huising M.O....Vale W.W. (2008)
    7. Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides. (PubMed id 8557170)1, 9 Behan D.P....Vale W.W. (1995)
    8. CRH-BP: the regulation and function of a phylogenetically conserved binding protein. (PubMed id 16368564)1, 9 Westphal N.J. and Seasholtz A.F. (2006)
    9. Amniotic fluid and umbilical cord plasma corticotropin-releasing factor (CRF), CRF-binding protein, adrenocorticotropin, and cortisol concentrations in intraamniotic infection and inflammation at term. (PubMed id 18559919)1, 9 Florio P....Petraglia F. (2008)
    10. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PubMed id 18974851)1, 9 Enoch M.A....Goldman D. (2008)

    External Searches for CRHBP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRHBP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1393 HGNC: 2356 AceView: CRHBP Ensembl:ENSG00000145708 euGenes: HUgn1393
    ECgene: CRHBP H-InvDB: CRHBP

    Other Databases showing CRHBP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRHBP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRHBP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CRHBP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRHBP gene:
    Search GeneIP for patents involving CRHBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CRHBP gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CRHBP (CRHBP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CRHBP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRHBP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRHBP  
     OriGene Protein Over-expression Lysate for CRHBP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CRHBP   OriGene 3'-UTR Clone for CRHBP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRHBP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CRHBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRHBP   OriGene Custom Protein Services for CRHBP  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRHBP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRHBP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHBP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
     GenScript Custom Purified and Recombinant Proteins Services for CRHBP GenScript cDNA clones with any tag delivered in your preferred vector for CRHBP
     GenScript Custom Assay Services for CRHBP GenScript Custom Superior Antibodies Services for CRHBP
     GenScript Custom overexpressing Cell Line Services for CRHBP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CRHBP promoter
     Search Chromatin IP Primers for CRHBP
     RT2 qPCR Primer Assay in human, mouse, rat CRHBP
     GNC Network for CRHBP
     SABiosciences PCR Arrays including human, mouse, rat CRHBP
     Search Tocris compounds for CRHBP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CRHBP antibodies
     CRHBP proteins
     CRHBP lysates
     Search for Antibodies for CRHBP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CRHBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CRHBP




     CRHBP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CRHBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP
     SwitchGear 3'UTR luciferase reporter plasmids for CRHBP
     SwitchGear Promoter luciferase reporter plasmids for CRHBP
     ThermoFisher Antibodies for CRHBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CRHBP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4