Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRHBP Gene

protein-coding   GIFtS: 55
GCID: GC05P076248

Corticotropin Releasing Hormone Binding Protein

(Previous name: corticotropin releasing hormone-binding protein)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Corticotropin Releasing Hormone Binding Protein1 2     CRFBP2 3
Corticotropin Releasing Hormone-Binding Protein1 2     CRH-BP2 3
Corticotropin-Releasing Hormone-Binding Protein2 3     CRF-Binding Protein2 3
CRF-BP2 3     Corticotropin-Releasing Factor-Binding Protein2

External Ids:    HGNC: 23561   Entrez Gene: 13932   Ensembl: ENSG000001457087   OMIM: 1225595   UniProtKB: P243873   

Export aliases for CRHBP gene to outside databases

Previous GC identifers: GC05P075055 GC05P076483 GC05P076287 GC05P076332 GC05P076284 GC05P071455


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRHBP Gene:
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived
peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase
throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the
placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate
pituitary-adrenal stimulation in pregnancy. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRHBP Gene: 
CRHBP (corticotropin releasing hormone binding protein) is a protein-coding gene. Diseases associated with CRHBP include klebsiella, and acth-secreting pituitary adenoma. GO annotations related to this gene include corticotropin-releasing hormone binding and peptide binding.

UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

Gene Wiki entry for CRHBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRHBP gene promoter:
         GATA-3   AP-1   ATF-2   XBP-1   LCR-F1   GATA-1   GATA-2   AREB6   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRHBP promoter sequence
   Search SABiosciences Chromatin IP Primers for CRHBP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q

CRHBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRHBP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P076248:  view genomic region     (about GC identifiers)

Start:
76,248,538 bp from pter      End:
76,276,983 bp from pter
Size:
28,446 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387 (See protein sequence)
Recommended Name: Corticotropin-releasing factor-binding protein precursor  
Size: 322 amino acids; 36144 Da
Subcellular location: Secreted
Secondary accessions: Q53F32 Q6FHT5

Explore the universe of human proteins at neXtProt for CRHBP: NX_P24387

Explore proteomics data for CRHBP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24387

  • CRHBP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRHBP Protein Expression
    REFSEQ proteins: NP_001873.2  
    ENSEMBL proteins: 
     ENSP00000274368   ENSP00000426097  

    Human Recombinant Protein Products for CRHBP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CRHBP
    OriGene Protein Over-expression Lysate for CRHBP
    OriGene MassSpec for CRHBP 
    OriGene Custom Protein Services for CRHBP
    GenScript Custom Purified and Recombinant Proteins Services for CRHBP
    Novus Biologicals CRHBP Proteins
    Novus Biologicals CRHBP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CRHBP
    Cloud-Clone Corp. Proteins for CRHBP 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA1846945
    GO:0005622intracellular ISS--
    GO:0005634nucleus ISS--
    GO:0005767secondary lysosome ISS--
    GO:0005771multivesicular body ISS--

    CRHBP for ontologies           About GeneDecksing



    CRHBP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CRHBP
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CRHBP
    GenScript Custom Superior Antibodies Services for CRHBP
    Novus Biologicals CRHBP Antibodies
    Abcam antibodies for CRHBP
    Cloud-Clone Corp. Antibodies for CRHBP 
    ThermoFisher Antibodies for CRHBP
    LSBio Antibodies in human, mouse, rat for CRHBP 

    Assay Products for CRHBP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CRHBP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRHBP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRHBP 
    Cloud-Clone Corp. CLIAs for CRHBP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000859 CUB_dom
     IPR008435 CRF-bd

    Graphical View of Domain Structure for InterPro Entry P24387

    ProtoNet protein and cluster: P24387

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB008435 Corticotropin-releasing factor binding


    UniProtKB/Swiss-Prot: CRHBP_HUMAN, P24387
    Similarity: Belongs to the CRF-binding protein family


    CRHBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRHBP_HUMAN, P24387
    Function: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy

         Genatlas biochemistry entry for CRHBP:
    corticotropin releasing hormone binding protein

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18234674
    GO:0042277peptide binding ISS--
    GO:0051424corticotropin-releasing hormone binding IPI18234674
         
    CRHBP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRHBP:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crhbp):
     behavior/neurological  growth/size 

    CRHBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Crhbptm1Afs for CRHBP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRHBP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRHBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRHBP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRHBP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHBP
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCRHBP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRHBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CRHBP
    Sirion Biotech Customized adenovirus for overexpression of CRHBP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CRHBP (see all 7)
    OriGene ORF clones in mouse, rat for CRHBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRHBP (NM_001882)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP
    Sirion Biotech Customized lentivirus for stable overexpression of CRHBP 
                         Customized lentivirus expression plasmids for stable overexpression of CRHBP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CRHBP
    Search LifeMap BioReagents cell lines for CRHBP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRHBP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CRHBP (P243873 ENSP000002743684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCNP550893, ENSP000002960994I2D: score=2 STRING: ENSP00000296099
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001963synaptic transmission, dopaminergic ISS--
    GO:0002125maternal aggressive behavior ISS--
    GO:0006954inflammatory response IDA18559919
    GO:0007165signal transduction TAS7477348
    GO:0007565female pregnancy IEP1846945

    CRHBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRHBP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRHBP

    10 Novoseek inferred chemical compound relationships for CRHBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sauvagine 89.7 22 11572971 (4), 11179597 (3), 10656997 (1), 11223175 (1) (see all 6)
    astressin 69.7 5 11179597 (1), 11572971 (1), 7479843 (1)
    acth 68.9 18 2161424 (4), 18559919 (3), 7889116 (2), 7867564 (2) (see all 9)
    prostaglandin 33.4 5 7559899 (2), 17766709 (1), 8964581 (1)
    hydrocortisone 16.7 3 11441903 (2), 7889116 (1)
    estrogen 5.58 5 9589664 (2), 15345745 (2)
    forskolin 1.69 4 8581494 (2), 9886832 (1)
    dexamethasone 0.321 5 9886832 (2), 9589664 (1), 10992187 (1)
    estradiol 0 3 15345745 (2), 10443686 (1)
    progesterone 0 1 10443686 (1)

    Search CenterWatch for drugs/clinical trials and news about CRHBP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRHBP gene: 
    NM_001882.3  

    Unigene Cluster for CRHBP:

    Corticotropin releasing hormone binding protein
    Hs.115617  [show with all ESTs]
    Unigene Representative Sequence: NM_001882
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274368(uc010izx.3 uc003ker.3) ENST00000506501 ENST00000512446
    ENST00000514258 ENST00000503763
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRHBP
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CRHBP:
    hsa-miR-200c hsa-miR-187* hsa-miR-429 hsa-miR-561 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCRHBP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CRHBP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP
    Clone
    Products:
         
    OriGene clones in human, mouse for CRHBP (see all 7)
    OriGene ORF clones in mouse, rat for CRHBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRHBP (NM_001882)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRHBP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP
    Sirion Biotech Customized lentivirus for stable overexpression of CRHBP 
                         Customized lentivirus expression plasmids for stable overexpression of CRHBP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CRHBP
    OriGene qSTAR qPCR primer pairs in human, mouse for CRHBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRHBP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP

    Additional mRNA sequence: 

    AK223457.1 AK307729.1 AK311052.1 BC018038.1 CR541666.1 X58022.1 

    7 DOTS entries:

    DT.453176  DT.92423869  DT.40116422  DT.40118540  DT.95266598  DT.120828461  DT.91840282 

    24/90 AceView cDNA sequences (see all 90):

    CR606509 CF552795 NM_001882 CR622343 BX090453 CR592351 AI985546 BM547365 
    AV652073 CR616423 AV646516 CR594674 AW451896 CF529190 BE552125 AV651422 
    CR625877 N64763 N76172 AI915914 BX387647 BX377811 AL575674 CD357999 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRHBP expression in normal human tissues (normalized intensities)      CRHBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAAATTT
    CRHBP Expression
    About this image


    CRHBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)
             hIPS1
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)

    See CRHBP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRHBP

    SOURCE GeneReport for Unigene cluster: Hs.115617
        SABiosciences Expression via Pathway-Focused PCR Array including CRHBP: 
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRHBP
    OriGene qSTAR qPCR primer pairs in human, mouse for CRHBP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRHBP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRHBP gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crhbp1 , 5 corticotropin releasing hormone binding protein1, 5 85.92(n)1
    87.27(a)1
      13 (49.50 cM)5
    129191  NM_198408.31  NP_940800.11 
     954313765 
    chicken
    (Gallus gallus)
    Aves CRHBP1 corticotropin releasing hormone binding protein 74.74(n)
    73.91(a)
      427214  XM_424801.3  XP_424801.2 
    lizard
    (Anolis carolinensis)
    Reptilia CRHBP6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    2(14091617-14107306)
    African clawed frog
    (Xenopus laevis)
    Amphibia crhbp-A2 corticotropin releasing hormone binding protein 72.7(n)    U41858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crhbp1 corticotropin releasing hormone binding protein 65.3(n)
    63.72(a)
      445065  NM_001003459.1  NP_001003459.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG155371 CG15537 44(n)
    30.22(a)
      43614  NM_001104511.2  NP_001097981.1 


    ENSEMBL Gene Tree for CRHBP (if available)
    TreeFam Gene Tree for CRHBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/415 SNPs in CRHBP are shown (see all 415)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810170461,2
    --76246786(+) CTTGTC/TTTCCA 1 -- us2k10--------
    rs731239331,2
    C,F--76246811(+) GTTTTT/CCTCGA 1 -- us2k13Minor allele frequency- C:0.16WA NA 240
    rs328961,2
    C,F--76246859(-) TAAAAA/CAAAAA 1 -- us2k1 tfbs3 trp33Minor allele frequency- C:0.12NA EA 242
    rs1856893401,2
    --76246911(+) TGGTGA/CAAACT 1 -- us2k10--------
    rs785698151,2
    F--76247094(+) TGACAG/CCAGGG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs585177221,2
    C,F--76247134(+) CATGCG/ATGCAT 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1884803781,2
    --76247165(+) ATGTGC/TATATG 1 -- us2k10--------
    rs348181881,2
    C,F--76247254(+) TGCCAG/CACCCC 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs125181181,2
    C,F,H--76247314(+) GGGAAC/GAGGCC 1 -- us2k12Minor allele frequency- G:0.05NA EA 240
    rs1416607071,2
    C--76247324(+) CAAGGA/GCTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRHBP (76248538 - 76276983 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CRHBP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830355CNV Gain17160897
    nsv823102CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CRHBP
    DNA2.0 Custom Variant and Variant Library Synthesis for CRHBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 122559    OMIM disorders: --

    20/21 diseases for CRHBP (see all 21):    About MalaCards
    klebsiella    acth-secreting pituitary adenoma    bacterial vaginosis    addison's disease
    hypopituitarism    cushing's syndrome    major depressive disorder    pituitary adenoma
    eclampsia    pre-eclampsia    peritonitis    bipolar disorder
    alzheimer's disease    adenoma    pneumonia    alcoholism
    obesity    schizophrenia    hypertension    cervicitis


    CRHBP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for CRHBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypercortisolemia 52.4 2 2169481 (1), 11441903 (1)
    cushing syndrome 48.4 9 2169481 (4), 7889116 (2), 9589664 (1)
    addisons disease 36.5 4 7889116 (2), 2169481 (2)
    preeclampsia 30.8 3 7756202 (1), 15356079 (1), 7852886 (1)
    preterm delivery 30.7 5 10992187 (2), 17636237 (2)
    hypopituitarism 30 2 7889116 (1), 2169481 (1)
    major depression 23.6 8 14573312 (4), 17599466 (2), 15996902 (1), 16482088 (1)
    inflammation 0 2 18559919 (1), 10443681 (1)
    alzheimers disease 0 1 9109532 (1)

    Genetic Association Database (GAD): CRHBP
    Human Genome Epidemiology (HuGE) Navigator: CRHBP (23 documents)

    Export disorders for CRHBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRHBP gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with CRHBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and structure of the human corticotrophin releasing factor- binding protein gene (CRHBP). (PubMed id 8198617)1, 2, 3, 9 Behan D.P.... Vale W.W. (1993)
    2. Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. (PubMed id 18974851)1, 4, 9 Enoch M.A....Goldman D. (2008)
    3. Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in recurrent major depressive disorder. (PubMed id 17599466)1, 4, 9 Van Den Eede F....Claes S.J. (2007)
    4. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)1, 4, 9 Claes S....Van Broeckhoven C. (2003)
    5. Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PubMed id 19131402)1, 4, 9 Ryckman K.K....Williams S.M. (2009)
    6. Assignment of disulfide bonds in corticotropin-releasing factor- binding protein. (PubMed id 8307998)1, 2, 9 Fischer W.H.... Vale W.W. (1994)
    7. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. (PubMed id 1846945)1, 2, 9 Potter E....Vale W.W. (1991)
    8. Genetic variation in the hypothalamic-pituitary-adren al stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study. (PubMed id 19723618)1, 4 Holliday K.L....McBeth J. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study . (PubMed id 20403506)1, 4 Holliday K.L....McBeth J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1393 HGNC: 2356 AceView: CRHBP Ensembl:ENSG00000145708 euGenes: HUgn1393
    ECgene: CRHBP H-InvDB: CRHBP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRHBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRHBP gene:
    Search GeneIP for patents involving CRHBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CRHBP (CRHBP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CRHBP  
     OriGene qPCR primer pairs and template standards for CRHBP   OriGene Protein Over-expression Lysate for CRHBP  
     OriGene MassSpec something-or-other for CRHBP   OriGene clones in human, mouse for CRHBP  
     OriGene qSTAR qPCR primer pairs in human, mouse for CRHBP   OriGene Purified Protein for CRHBP  
     OriGene ORF clones in mouse, rat for CRHBP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CRHBP   OriGene Custom Protein Services for CRHBP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CRHBP
     QIAGEN SeqTarget long-range PCR primers for resequencing CRHBP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRHBP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRHBP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRHBP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRHBP
     GenScript Custom Purified and Recombinant Proteins Services for CRHBP GenScript cDNA clones with any tag delivered in your preferred vector for CRHBP
     GenScript Custom Assay Services for CRHBP GenScript Custom Superior Antibodies Services for CRHBP
     GenScript Custom overexpressing Cell Line Services for CRHBP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CRHBP promoter
     Search Chromatin IP Primers for CRHBP
     RT2 qPCR Primer Assay in human, mouse, rat CRHBP
     GNC Network for CRHBP
     SABiosciences PCR Arrays including human, mouse, rat CRHBP
     Search Tocris compounds for CRHBP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CRHBP antibodies
     CRHBP proteins
     CRHBP lysates
     Antibodies for CRHBP
     See all of Abcam's Antibodies, Kits and Proteins for CRHBP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CRHBP




     Proteins for CRHBP
     Antibodies for CRHBP
     ELISAs for CRHBP
     CLIAs for CRHBP
     Search LifeMap BioReagents cell lines for CRHBP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRHBP
     SwitchGear 3'UTR luciferase reporter plasmids for CRHBP
     SwitchGear Promoter luciferase reporter plasmids for CRHBP
     ThermoFisher Antibodies for CRHBP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRHBP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CRHBP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRHBP
    Customized:
     lentivirus for stable overexpression of CRHBP
     lentivirus expression plasmids for stable overexpression of CRHBP
     adenovirus for overexpression of CRHBP
     LSBio Antibodies in human, mouse, rat for CRHBP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CRHBP gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4