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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRH Gene

protein-coding   GIFtS: 61
GCID: GC08M067088

corticotropin releasing hormone
 Explore 168 diseases affiliated with
CRH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRH    

Aliases
for CRH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Corticotropin Releasing Hormone1 2
CRF1 2 3
Corticotropin-Releasing Factor2 3
Corticoliberin1
Corticotropin-Releasing Hormone3

External Ids:    HGNC: 23551   Entrez Gene: 13922   Ensembl: ENSG000001475717   OMIM: 1225605   UniProtKB: P068503   

Export aliases for CRH gene to outside databases

Previous GC identifers: GC08M066208 GC08M067028 GC08M066811 GC08M067138 GC08M067251 GC08M062579


Summaries
for CRH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRH:
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to
stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal
recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including
hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in
peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that
determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels
of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this
protein may act as a trigger for parturition. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850
Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

summary for CRH:
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of
homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been
suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned
from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified
in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH (Corticotropin-releasing hormone)


Genomic Views
for CRH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRH gene promoter:
         AP-1   ATF-2   NRSF form 1   NF-kappaB   NRSF form 2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRH promoter sequence
   Search SABiosciences Chromatin IP Primers for CRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13

CRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067088:  view genomic region     (about GC identifiers)

Start:
 67,088,612 bp from pter      End:
 67,090,960 bp from pter
Size:
 2,349 bases      Orientation:
 minus strand

Proteins
for CRH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRF_HUMAN, P06850 (See protein sequence)
Recommended Name: Corticoliberin precursor  
Size: 196 amino acids; 21422 Da
Subunit: Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain)
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CRH:
3EHT (3D)        3EHU (3D)    
Secondary accessions: B3KQS4

Explore the universe of human proteins at neXtProt for CRH: NX_P06850

CRH Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_000747.1  
ENSEMBL proteins: 
 ENSP00000276571  
Reactome Protein details: P06850
Human Recombinant Protein Products: 
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OriGene Protein Over-expression Lysate: CRH
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Novus Biologicals CRH Proteins
Novus Biologicals CRH Lysates
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Browse ProSpec Recombinant Proteins
Uscn Proteins for CRH

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA18559919
GO:0005625soluble fraction ----
GO:0005737cytoplasm IEA--
GO:0043196varicosity IEA--


CRH for ontologies           About GeneDecksing



CRH Antibody Products: 
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Uscn Antibodies for CRH
ThermoFisher Antibodies for CRH

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Uscn ELISAs and CLIAs for CRH

Protein Domains /
Families
for CRH gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
CRH for domains           About GeneDecksing

3 InterPro domains/families:
 IPR018446 Corticotropin-releasing_fac_CS
 IPR000187 Corticotropin-releasing_factor
 IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P06850

ProtoNet protein and cluster: P06850

1 Blocks protein family: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


Function
for CRH gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: CRF_HUMAN, P06850
Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

     Genatlas biochemistry entry for CRH:
corticotropin releasing hormone

miRNA
Products:    		 OriGene 3'-UTR Clone: CRH
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmid: CRH 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRH (see all 7)
OriGene shRNA RFP: CRH
OriGene siRNA: CRH
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRH

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for CRH

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CRH (NM_000756)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRH 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for CRH
Search LifeMap BioReagents cell lines for CRH

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS7477348
GO:0005179hormone activity TAS7585095
GO:0005184neuropeptide hormone activity TAS7867564
GO:0005515protein binding IPI18801728
GO:0017045corticotropin-releasing hormone activity IEA--


CRH for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Crhtm1Maj for CRH
     12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crh):
 behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
 homeostasis/metabolism  immune system  integument  nervous system  normal 
 other  respiratory system 

CRH for phenotypes           About GeneDecksing


Pathways & Interactions
for CRH gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
2G beta:gamma signalling through PLC beta
Class B/2 (Secretin family receptors)0.20
G alpha (s) signalling events0.14
3Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics1.00
4Selected targets of CREB1
Selected targets of CREB11.00
5Long-term depression
Long-term depression1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CRH
    Selected targets of CREB1

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRH
    CRHR Pathway

2 BioSystems Pathways for CRH 
    Myometrial Relaxation and Contraction Pathways
Rapid glucocorticoid signaling

5/6        Reactome Pathways for CRH (see all 6)
    GPCR downstream signaling
Signal Transduction
Signaling by GPCR
GPCR ligand binding
Class B/2 (Secretin family receptors)

1 PharmGKB Pathway for CRH
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

1         Kegg Pathway  (Kegg details for CRH):
    Long-term depression


CRH for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for CRH (P068501, 3 ENSP000002765714) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
InteractantInteraction Details
GeneCardExternal ID(s)
CRHR1P349981, 3, ENSP000003813334EBI-3870390,EBI-3870393 I2D: score=2 STRING: ENSP00000381333
CRHR2Q133243I2D: score=2 
ADCY2ENSP000003429524STRING: ENSP00000342952
ADCY5ENSP000004193614STRING: ENSP00000419361
ADCY6ENSP000003114054STRING: ENSP00000311405
About this table

Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation IEA--
GO:0001963synaptic transmission, dopaminergic IDA12895416
GO:0006704glucocorticoid biosynthetic process IEA--
GO:0006950response to stress ----
GO:0006954inflammatory response IDA18559919


CRH for ontologies           About GeneDecksing



Drugs & Compounds
for CRH gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRH for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for CRH available from Tocris Bioscience    About this table
CompoundAction CAS #
NBI 27914 hydrochlorideSelective non-peptide CRF1 antagonist[184241-44-9]
Astressin 2BSelective CRF2 antagonist[681260-70-8]
SauvagineCRF agonist[74434-59-6]
alpha-helical CRF 9-41CRF receptor antagonist--
AstressinPotent CRF receptor antagonist[170809-51-5]

3 DrugBank Compounds for CRH    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
CorticotropinACTH (see all 5)9002-60-2targetagonist16503922 16534240 16472586 16467980 16523405
Alpha-Aminoisobutyric Acid-- --target--10592235
D-Phenylalanine-- 673-06-3target--10592235

10/132 Novoseek chemical compound relationships for CRH gene (see all 132)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
acth 95.3 2061 11380490 (9), 1983217 (8), 9274696 (7), 9841549 (7) (see all 99)
sauvagine 92.1 130 9326293 (3), 8822168 (3), 9612279 (3), 10777063 (3) (see all 48)
hcrh 91.8 44 1651955 (2), 7675936 (1), 10843178 (1), 17186287 (1) (see all 31)
astressin 90.4 38 9030428 (2), 12679466 (2), 11902119 (2), 17568667 (2) (see all 23)
antalarmin 88 31 9629233 (2), 10822340 (2), 15916629 (2), 10456290 (1) (see all 20)
dexamethasone 78.8 477 15950349 (9), 17825799 (7), 8386285 (6), 18926641 (6) (see all 99)
metyrapone 72.4 69 2155255 (5), 1473519 (4), 7970937 (3), 7753338 (3) (see all 26)
corticosterone 71.9 137 20308419 (3), 1319007 (3), 11959675 (3), 2156674 (3) (see all 63)
arginine 66.5 249 17566099 (4), 7895915 (2), 20368512 (2), 1658546 (2) (see all 99)
pivagabine 62 4 9450153 (1), 9450157 (1)

Search CenterWatch for drugs/clinical trials and news about CRH / CRF 

Transcripts
for CRH gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for CRH gene: 
NM_000756.2  

Unigene Cluster for CRH:

Corticotropin releasing hormone
Hs.75294  [show with all ESTs]
Unigene Representative Sequence: NM_000756
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000276571(uc003xvy.2)

miRNA
Products:     		 OriGene 3'-UTR Clone: CRH
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmid: CRH 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRH (see all 7)
OriGene shRNA RFP: CRH
OriGene siRNA: CRH
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRH
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CRH (NM_000756)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRH 
Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRH
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRH
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRH

Additional cDNA sequence: 

AK075431.1 BC002599.2 BC011031.1 BT007453.1 

4 DOTS entries:

DT.213036  DT.92426756  DT.100682388  DT.97842166 

24/118 AceView cDNA sequences (see all 118):

CR592854 CA774731 CR625216 NM_000756 BX104521 CA442822 BQ023511 CA774978 
BF196912 BQ026679 F03116 CR619891 CR603754 AI160513 CR626513 AK075431 
AW513134 CR617485 BQ026511 F05084 BC002599 BX345878 BG572446 CB961608 

GeneLoc Exon Structure


Expression
for CRH gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

CRH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
Early limb mesenchymal cells (ELM cells) (Primary Cell)Bone, Cartilage, Limb
Syncytiotrophoblast-like cells (Generation of syncyt...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See CRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRH

SOURCE GeneReport for Unigene cluster: Hs.75294
    SABiosciences Expression via Pathway-Focused PCR Arrays including CRH: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRH
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRH
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRH
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH

Orthologs
for CRH gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for CRH gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Crh1 , 5 corticotropin releasing hormone1, 5 83.6(n)1
82.35(a)1		   3 (5.75 cM)5
129181  NM_205769.21  NP_991338.11 
 196934015 
chicken
(Gallus gallus)		 Aves CRH1 corticotropin releasing hormone 71.29(n)
68.07(a)		   404297  NM_001123031.1  NP_001116503.1 
lizard
(Anolis carolinensis)		 Reptilia CRH6
 --
 56(a)
 1 ↔ 1
 4(30730518-30731126)
zebrafish
(Danio rerio)		 Actinopterygii Dr.291642 Transcribed sequence with moderate similarity to protein more 76.98(n)    AL923634.1 


ENSEMBL Gene Tree for CRH (if available)
TreeFam Gene Tree for CRH (if available) 

Paralogs
for CRH gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for CRH gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/76 NCBI SNPs in CRH are shown (see all 76)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 8 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs801267121,2
C,F,--62578361(+) TAGAAA/GAAGAA 1 -- ds50011Minor allele frequency- G:0.02WA 118
rs69823941,2
C,F,H,--62578632(+) AGCCAC/ATGACA 1 -- ds500115Minor allele frequency- A:0.11NS EA NA CSA WA 1892
rs74599241,2
H--62579100(+) CACGTG/CAATAC 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 420
rs725563981,2
C,--62579817(-) CTCCTG/CCCCTG 2 /L syn11Minor allele frequency- C:0.02--64
rs127215111,2
C,H--62579864(-) ACATGC/GGGCTG 2 R G mis1 ese35Minor allele frequency- G:0.18NS EA 514
rs1129626841,2
--62579940(+) AAGAGC/TTGGTT 1 -- int11Minor allele frequency- T:0.50CSA 2
rs786445171,2
F,--62580003(+) AGACGT/GGCTGG 1 -- int11Minor allele frequency- G:0.07WA 118
rs283640181,2
C,F,H,--62580025(-) TCCGAA/CTCACT 1 -- int115Minor allele frequency- C:0.04NS EA WA NA 2938
rs768783221,2
C,F,--62580145(+) AGACTC/TTGAAA 1 -- int11Minor allele frequency- T:0.04WA 118
rs736939331,2
C,--62580463(+) TTGTAA/CTCTTA 1 -- int12Minor allele frequency- C:0.06WA 120

HapMap Linkage Disequilibrium report for CRH (67088612 - 67090960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CRH: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRH
DNA2.0 Custom Variant and Variant Library Synthesis for CRH

Disorders / Diseases
for CRH gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
CRH for disorders           About GeneDecksing

OMIM gene information: 122560    OMIM disorders: --

20/168 diseases for CRH (see all 168):    About MalaCards
autosomal dominant nocturnal frontal lobe epilepsy    frontal lobe epilepsy    post-traumatic stress disorder    pituitary-dependent cushing's disease
hypoglycemia    21-hydroxylase deficiency    alzheimer's disease    spinal cord injury
seasonal affective disorder    eosinophilia-myalgia syndrome    obsessive-compulsive disorder    growth hormone deficiency
langerhans-cell histiocytosis    neurohypophyseal diabetes insipidus    adrenocorticotropic hormone deficiency    pituitary hormone deficiency
acth deficiency    combined pituitary hormone deficiency    isolated acth deficiency    adrenal hyperplasia

18 diseases from the University of Copenhagen DISEASES database for CRH:
Cushing's syndrome     Irritable bowel syndrome     pituitary-dependent Cushing's disease     Nelson syndrome
Anxiety disorder     Pituitary adenoma     Adenoma     Hypoglycemia
Alcohol dependence     Addison's disease     Hypopituitarism     Pain agnosia
Substance abuse     Hypertension     Adrenal adenoma     Melancholia
Endogenous depression     Drug dependence

10/91 Novoseek disease relationships for CRH gene (see all 91)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cushing syndrome 85.9 141 7641409 (5), 7891545 (4), 17039427 (3), 1597149 (3) (see all 66)
hypercortisolism 82 50 9696732 (2), 16478558 (2), 9238254 (2), 8097579 (2) (see all 31)
acth syndrome ectopic 81.2 23 8254033 (4), 7958079 (3), 9274696 (1), 11729609 (1) (see all 10)
acth deficiency 80.6 6 8882784 (2), 1660365 (1), 1313844 (1), 9152624 (1) (see all 5)
pituitary-dependent cushings disease 75.2 8 8157708 (1), 1848486 (1), 7891545 (1), 2178536 (1) (see all 6)
major depression 71.3 127 16478558 (3), 19846118 (2), 9893154 (2), 17825799 (2) (see all 70)
hypercortisolemia 66.3 6 11086823 (1), 1651955 (1), 18406750 (1), 12679470 (1)
mood disorders 62.9 57 15705605 (4), 11337098 (2), 9662725 (2), 12438692 (1) (see all 38)
pituitary adenoma 62.2 24 15829152 (2), 7958079 (2), 8254033 (2), 8386895 (1) (see all 15)
anxiety disorders 61.7 64 16594259 (3), 8491091 (2), 9854171 (2), 10599479 (2) (see all 36)

Genatlas disease: CRH
congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

GeneTests: CRH
Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant

Genetic Association Database (GAD): CRH
Human Genome Epidemiology (HuGE) Navigator: CRH (56 documents)

Export disorders for CRH gene to outside databases

Publications
for CRH gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CRH gene, integrated from 9 sources (see all 1942):
(articles sorted by number of sources associating them with CRH)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. (PubMed id 18801728)1, 2, 9 Pioszak A.A....Xu H.E. (2008)
  2. Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PubMed id 12734882)1, 4, 9 Gonzalez-Gay M.A....Ollier W.E. (2003)
  3. Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro. (PubMed id 16523405)1, 7, 9 Wagner U....Baerwald C.G. (2006)
  4. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)1, 4, 9 Claes S....Van Broeckhoven C. (2003)
  5. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PubMed id 11555839)1, 4, 9 Rosmond R....Bjorntorp P. (2001)
  6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. (PubMed id 12154211)1, 4 Donn R.P....Thomson W. (2002)
  9. Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. (PubMed id 12051390)1, 4 Gonzalez-Gay M.A....Ollier W.E. (2002)
  10. Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. (PubMed id 8386360)1, 2 Romier C.... Darbon H. (1993)

External Searches for CRH gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
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Genome Databases showing CRH gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1392 HGNC: 2355 AceView: CRH Ensembl:ENSG00000147571 euGenes: HUgn1392
ECgene: CRH Kegg: 1392 H-InvDB: CRH

Other Databases showing CRH gene

(According to HUGE)
About This Section
   --

Specialized Databases showing CRH gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CRH Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone

Intellectual Property
for CRH gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CRH gene:
Search GeneIP for patents involving CRH

Licensable Technologies for CRH gene:
 Salk Institute:
  • Corticotropin Releasing Factor-Binding Protein (CRF-BP)
    		•    (see first 1)
  • Corticotropin-Releasing Factor Overproducing Transgenic Mice
    • GeneCards and IP:
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