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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRH Gene

protein-coding   GIFtS: 62
GCID: GC08M067088

Corticotropin Releasing Hormone

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Corticotropin Releasing Hormone1 2
Corticotropin-Releasing Factor1 2 3
corticoliberin1 2
CRF2 3
Corticotropin-Releasing Hormone3

External Ids:    HGNC: 23551   Entrez Gene: 13922   Ensembl: ENSG000001475717   OMIM: 1225605   UniProtKB: P068503   

Export aliases for CRH gene to outside databases

Previous GC identifers: GC08M066208 GC08M067028 GC08M066811 GC08M067138 GC08M067251 GC08M062579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRH Gene:
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response
to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal
recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences
including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also
synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta
it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid
increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to
its metabolic functions, this protein may act as a trigger for parturition. (provided by RefSeq, Apr 2010)

GeneCards Summary for CRH Gene: 
CRH (corticotropin releasing hormone) is a protein-coding gene. Diseases associated with CRH include crh-related related nocturnal frontal lobe epilepsy, autosomal dominant, and autosomal dominant nocturnal frontal lobe epilepsy, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include neuropeptide hormone activity and receptor binding.

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850
Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

summary for CRH Gene:
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of
homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been
suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned
from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified
in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH (Corticotropin-releasing hormone) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRH gene promoter:
         AP-1   ATF-2   NRSF form 1   NF-kappaB   NRSF form 2   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRH promoter sequence
   Search SABiosciences Chromatin IP Primers for CRH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13

CRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRH gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067088:  view genomic region     (about GC identifiers)

Start:
67,088,612 bp from pter      End:
67,090,960 bp from pter
Size:
2,349 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850 (See protein sequence)
Recommended Name: Corticoliberin precursor  
Size: 196 amino acids; 21422 Da
Subunit: Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain)
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CRH:
3EHT (3D)        3EHU (3D)    
Secondary accessions: B3KQS4

Explore the universe of human proteins at neXtProt for CRH: NX_P06850

Explore proteomics data for CRH at MOPED 

CRH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CRH Protein Expression

REFSEQ proteins: NP_000747.1  
ENSEMBL proteins: 
 ENSP00000276571  
Reactome Protein details: P06850
Human Recombinant Protein Products for CRH: 
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OriGene Protein Over-expression Lysate for CRH
OriGene Custom MassSpec 
OriGene Custom Protein Services for CRH
GenScript Custom Purified and Recombinant Proteins Services for CRH
Novus Biologicals CRH Proteins
Novus Biologicals CRH Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CRH 

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IDA18559919
GO:0005737cytoplasm IEA--
GO:0043025neuronal cell body ----
GO:0043196varicosity IEA--

CRH for ontologies           About GeneDecksing



CRH Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CRH (Pro-Corticoliberin/Pro-CRH)
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Novus Biologicals CRH Antibodies
Abcam antibodies for CRH
Cloud-Clone Corp. Antibodies for CRH 
ThermoFisher Antibodies for CRH
LSBio Antibodies in human, mouse, rat for CRH 

Assay Products for CRH: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CRH
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CRH
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CRH 
Cloud-Clone Corp. CLIAs for CRH


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

3 InterPro protein domains:
 IPR018446 Corticotropin-releasing_fac_CS
 IPR000187 Corticotropin-releasing_factor
 IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P06850

ProtoNet protein and cluster: P06850

1 Blocks protein domain: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850
Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family


CRH for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CRF_HUMAN, P06850
Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

     Genatlas biochemistry entry for CRH:
corticotropin releasing hormone

     Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS7477348
GO:0005179hormone activity TAS7585095
GO:0005184neuropeptide hormone activity TAS7867564
GO:0005515protein binding IPI18234674
GO:0017045corticotropin-releasing hormone activity IEA--
     
CRH for ontologies           About GeneDecksing


Phenotypes:
     12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crh):
 behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
 homeostasis/metabolism  immune system  integument  nervous system  normal 
 other  respiratory system 

CRH for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Crhtm1Maj for CRH

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CRH 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRH

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRH 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRH 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidCRH 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CRH
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRH

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CRH
Sirion Biotech Customized adenovirus for overexpression of CRH

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CRH (see all 8)
OriGene ORF clones in mouse, rat for CRH
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRH (NM_000756)
Sino Biological Human cDNA Clone for CRH
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRH
Sirion Biotech Customized lentivirus for stable overexpression of CRH 
                     Customized lentivirus expression plasmids for stable overexpression of CRH 

Cell Line
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GenScript Custom overexpressing Cell Line Services for CRH
Search LifeMap BioReagents cell lines for CRH
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CRH About   (see all 10)                                                                                              See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Prostacyclin signalling through prostacyclin receptor
Class B/2 (Secretin family receptors)0.36
G alpha (s) signalling events0.31
3Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding0.71
4G-Beta Gamma Signaling
CRHR Pathway0.44
5Calcium Regulation in the Cardiac Cell
Myometrial Relaxation and Contraction Pathways0.43

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for CRH
    Selected targets of CREB1

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRH
    CRHR Pathway

2 BioSystems Pathways for CRH
    Myometrial Relaxation and Contraction Pathways
Rapid glucocorticoid signaling


5/6        Reactome Pathways for CRH (see all 6)
    GPCR downstream signaling
Signal Transduction
Signaling by GPCR
GPCR ligand binding
Class B/2 (Secretin family receptors)

1 PharmGKB Pathway for CRH
    Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

2         Kegg Pathways  (Kegg details for CRH):
    Long-term depression
Alcoholism


CRH for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for CRH (P068501, 3 ENSP000002765714) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
InteractantInteraction Details
GeneCardExternal ID(s)
CRHR1P349981, 3, ENSP000003813334EBI-3870390,EBI-3870393 I2D: score=2 STRING: ENSP00000381333
CRHR2Q133243I2D: score=2 
ADCY2ENSP000003429524STRING: ENSP00000342952
ADCY5ENSP000004193614STRING: ENSP00000419361
ADCY6ENSP000003114054STRING: ENSP00000311405
About this table

Gene Ontology (GO): 5/54 biological process terms (GO ID links to tree view) (see all 54):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001934positive regulation of protein phosphorylation IEA--
GO:0001963synaptic transmission, dopaminergic IDA12895416
GO:0006704glucocorticoid biosynthetic process IEA--
GO:0006950response to stress ----
GO:0006954inflammatory response IDA18559919

CRH for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRH for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for CRH available from Tocris Bioscience    About this table
CompoundAction CAS #
Urocortin (human)Endogenous CRF agonist[176591-49-4]
Urocortin (rat)Endogenous CRF agonist[171543-83-2]
alpha-helical CRF 9-41CRF receptor antagonist[90880-23-2]
CRF (human, rat) Stimulates ACTH release[86784-80-7]
AstressinPotent CRF receptor antagonist[170809-51-5]

3 DrugBank Compounds for CRH    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
CorticotropinACTH (see all 5)9002-60-2targetagonist16503922 16534240 16472586 16467980 16523405
Alpha-Aminoisobutyric Acid-- --target--10592235
D-Phenylalanine-- 673-06-3target--10592235

10/132 Novoseek inferred chemical compound relationships for CRH gene (see all 132)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
acth 95.3 2061 11380490 (9), 1983217 (8), 9274696 (7), 9841549 (7) (see all 99)
sauvagine 92.1 130 9326293 (3), 8822168 (3), 9612279 (3), 10777063 (3) (see all 48)
hcrh 91.8 44 1651955 (2), 7675936 (1), 10843178 (1), 17186287 (1) (see all 31)
astressin 90.4 38 9030428 (2), 12679466 (2), 11902119 (2), 17568667 (2) (see all 23)
antalarmin 88 31 9629233 (2), 10822340 (2), 15916629 (2), 10456290 (1) (see all 20)
dexamethasone 78.8 477 15950349 (9), 17825799 (7), 8386285 (6), 18926641 (6) (see all 99)
metyrapone 72.4 69 2155255 (5), 1473519 (4), 7970937 (3), 7753338 (3) (see all 26)
corticosterone 71.9 137 20308419 (3), 1319007 (3), 11959675 (3), 2156674 (3) (see all 63)
arginine 66.5 249 17566099 (4), 7895915 (2), 20368512 (2), 1658546 (2) (see all 99)
pivagabine 62 4 9450153 (1), 9450157 (1)

Search CenterWatch for drugs/clinical trials and news about CRH / CRF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRH gene: 
NM_000756.2  

Unigene Cluster for CRH:

Corticotropin releasing hormone
Hs.75294  [show with all ESTs]
Unigene Representative Sequence: NM_000756
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000276571(uc003xvy.2)
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
SwitchGear 3'UTR luciferase reporter plasmidCRH 3' UTR sequence
Inhib. RNA
Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRH
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OriGene ORF clones in mouse, rat for CRH
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GenScript: all cDNA clones in your preferred vector: CRH (NM_000756)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRH
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRH
Sirion Biotech Customized lentivirus for stable overexpression of CRH 
                     Customized lentivirus expression plasmids for stable overexpression of CRH 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CRH
OriGene qSTAR qPCR primer pairs in human, mouse for CRH
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRH
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRH
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRH

Additional mRNA sequence: 

AK075431.1 BC002599.2 BC011031.1 BT007453.1 

4 DOTS entries:

DT.213036  DT.92426756  DT.100682388  DT.97842166 

24/118 AceView cDNA sequences (see all 118):

CA774731 BQ026511 CA442822 BX345878 BF196912 F05084 NM_000756 CR619891 
BG572446 BQ026679 BC002599 AK075431 CR592854 CR626513 CR603754 CR617485 
F03116 AW513134 AI160513 CR625216 BX104521 CA774978 BQ023511 BF310436 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRH expression in normal human tissues (normalized intensities)      CRH embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CRH Expression
About this image


CRH expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 21 entries
         Thalamus
         Septum   
 
 Spinal Cord (Nervous System)    fully expand to see all 2 entries
         Dorsal Horn   
 
 Neural Tube (Nervous System)
         Metencephalon
 
 Eye (Sensory Organs)
         GABAergic Amacrine Cells Inner Nuclear Layer
 
 Placenta (Extraembryonic Tissues)

See CRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRH

SOURCE GeneReport for Unigene cluster: Hs.75294
    SABiosciences Expression via Pathway-Focused PCR Arrays including CRH: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Neurotrophins & Receptors in human mouse rat
          Obesity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CRH
OriGene qSTAR qPCR primer pairs in human, mouse for CRH
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRH
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRH
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRH
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRH gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Crh1 , 5 corticotropin releasing hormone1, 5 83.6(n)1
82.35(a)1
  3 (5.75 cM)5
129181  NM_205769.21  NP_991338.11 
 196934015 
chicken
(Gallus gallus)
Aves CRH1 corticotropin releasing hormone 71.29(n)
68.07(a)
  404297  NM_001123031.1  NP_001116503.1 
lizard
(Anolis carolinensis)
Reptilia CRH6
Uncharacterized protein
54(a)
1 ↔ 1
4(30730518-30731126)
zebrafish
(Danio rerio)
Actinopterygii Dr.291642 Transcribed sequence with moderate similarity to protein more 76.98(n)    AL923634.1 


ENSEMBL Gene Tree for CRH (if available)
TreeFam Gene Tree for CRH (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/92 SNPs in CRH are shown (see all 92)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs725563991,2
Cpathogenic167191786(-) TGTGAG/CATTCA 1 -- us2k11Minor allele frequency- C:0.01--96
rs127215101,2
C,F,Hpathogenic167192090(-) AGACAC/ACTGGT 1 -- us2k118Minor allele frequency- A:0.03NS EA NA 3142
rs1889222601,2
--67189033(+) AGATGC/TAGTCA 1 -- ds50010--------
rs801267121,2
C,F--67189114(+) TAGAAA/GAAGAA 1 -- ds50011Minor allele frequency- G:0.02WA 118
rs1812800801,2
--67189276(+) TTACCA/GTGTTT 1 -- ds50010--------
rs1863735421,2
--67189279(+) CCATGC/TTTTAG 1 -- ds50010--------
rs69823941,2
C,F,H--67189385(+) AGCCAC/ATGACA 1 -- ds500115Minor allele frequency- A:0.11NS EA NA CSA WA 1892
rs74599241,2
H--67189853(+) CACGTG/CAATAC 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 420
rs1908707951,2
C--67189980(+) TTTTTA/TAAATT 1 -- ut310--------
rs1499724701,2
C--67189984(+) TTAAA-/TTTTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for CRH (67088612 - 67090960 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CRH: --

Human Gene Mutation Database (HGMD): CRH
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CRH
DNA2.0 Custom Variant and Variant Library Synthesis for CRH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 122560    OMIM disorders: --

20/154 diseases for CRH (see all 154):    About MalaCards
crh-related related nocturnal frontal lobe epilepsy, autosomal dominant    autosomal dominant nocturnal frontal lobe epilepsy    pituitary-dependent cushing's disease    isolated acth deficiency
sheehan syndrome    nelson syndrome    petrositis    frontal lobe epilepsy
melancholia    postpartum depression    hypoadrenalism    eosinophilia-myalgia syndrome
neurohypophyseal diabetes insipidus    adrenal carcinoma    fasting hypoglycemia    fibromyalgia
post-traumatic stress disorder    chronic fatigue syndrome    acth deficiency    endogenous depression

20 diseases from the University of Copenhagen DISEASES database for CRH:
Cushing's syndrome     Kidney failure     Irritable bowel syndrome     Anxiety disorder
Pituitary adenoma     pituitary-dependent Cushing's disease     Hypoglycemia     Adenoma
Nelson syndrome     Hypopituitarism     Hypertension     Addison's disease
Alcohol dependence     Pain agnosia     Substance abuse     Melancholia
Adrenal adenoma     Withdrawal disorder     Endogenous depression     Amenorrhea

CRH for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/91 Novoseek inferred disease relationships for CRH gene (see all 91)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cushing syndrome 85.9 141 7641409 (5), 7891545 (4), 17039427 (3), 1597149 (3) (see all 66)
hypercortisolism 82 50 9696732 (2), 16478558 (2), 9238254 (2), 8097579 (2) (see all 31)
acth syndrome ectopic 81.2 23 8254033 (4), 7958079 (3), 9274696 (1), 11729609 (1) (see all 10)
acth deficiency 80.6 6 8882784 (2), 1660365 (1), 1313844 (1), 9152624 (1) (see all 5)
pituitary-dependent cushings disease 75.2 8 8157708 (1), 1848486 (1), 7891545 (1), 2178536 (1) (see all 6)
major depression 71.3 127 16478558 (3), 19846118 (2), 9893154 (2), 17825799 (2) (see all 70)
hypercortisolemia 66.3 6 11086823 (1), 1651955 (1), 18406750 (1), 12679470 (1)
mood disorders 62.9 57 15705605 (4), 11337098 (2), 9662725 (2), 12438692 (1) (see all 38)
pituitary adenoma 62.2 24 15829152 (2), 7958079 (2), 8254033 (2), 8386895 (1) (see all 15)
anxiety disorders 61.7 64 16594259 (3), 8491091 (2), 9854171 (2), 10599479 (2) (see all 36)

Genatlas disease: CRH
congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

GeneTests: CRH
GeneReviews: CRH
Genetic Association Database (GAD): CRH
Human Genome Epidemiology (HuGE) Navigator: CRH (56 documents)

Export disorders for CRH gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CRH gene, integrated from 9 sources (see all 1949):
(articles sorted by number of sources associating them with CRH)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. (PubMed id 18801728)1, 2, 9 Pioszak A.A....Xu H.E. (2008)
  2. Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PubMed id 12734882)1, 4, 9 Gonzalez-Gay M.A....Ollier W.E. (2003)
  3. Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study . (PubMed id 20403506)1, 4, 9 Holliday K.L....McBeth J. (2010)
  4. Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (PubMed id 19131402)1, 4, 9 Ryckman K.K....Williams S.M. (2009)
  5. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PubMed id 18384079)1, 4, 9 Keck M.E....Binder E.B. (2008)
  6. Association of HPA axis genes with suicidal behaviour in schizophrenia. (PubMed id 18838498)1, 4, 9 De Luca V....Kennedy J. (2008)
  7. Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro. (PubMed id 16523405)1, 7, 9 Wagner U....Baerwald C.G. (2006)
  8. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)1, 4, 9 Claes S....Van Broeckhoven C. (2003)
  9. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PubMed id 11555839)1, 4, 9 Rosmond R....Bjorntorp P. (2001)
  10. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1392 HGNC: 2355 AceView: CRH Ensembl:ENSG00000147571 euGenes: HUgn1392
ECgene: CRH Kegg: 1392 H-InvDB: CRH

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CRH Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CRH gene:
Search GeneIP for patents involving CRH

Licensable Technologies for CRH gene:
 Salk Institute:
  • Corticotropin Releasing Factor-Binding Protein (CRF-BP)
  •    (see first 1)
  • Corticotropin-Releasing Factor Overproducing Transgenic Mice
  • GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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