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Aliases for CRH Gene

Aliases for CRH Gene

  • Corticotropin Releasing Hormone 2 3 5
  • Corticotropin-Releasing Factor 2 3 4
  • Corticoliberin 2 3
  • CRF 3 4
  • Corticotropin-Releasing Hormone 4
  • CRH1 3

External Ids for CRH Gene

Previous GeneCards Identifiers for CRH Gene

  • GC08M067028
  • GC08M066811
  • GC08M067138
  • GC08M067251
  • GC08M062579
  • GC08M067088

Summaries for CRH Gene

Entrez Gene Summary for CRH Gene

  • This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

GeneCards Summary for CRH Gene

CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include Crh-Related Related Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CRH Gene

  • Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

Tocris Summary for CRH Gene

  • Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH Gene

Additional gene information for CRH Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRH Gene

Genomics for CRH Gene

Regulatory Elements for CRH Gene

Enhancers for CRH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H066118 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +53.8 53808 13 PKNOX1 FOXA2 ATF1 ZNF133 SIN3A FEZF1 YY1 TCF12 GATA2 ATF7 CRH PIR59286 GC08P066144 GC08P066139 GC08P066170
GH08H066141 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 +36.2 36235 2.2 CTCF ETV1 BACH1 RAD21 MEF2D CTBP1 CREB1 SPI1 TRY-GTA5-1 CRH RRS1-AS1 RRS1 ADHFE1 LINC00967 PIR59286 GC08P066170 GC08P066144 GC08P066139
GH08H066131 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +45.7 45659 2.2 CEBPB CEBPG IRF9 ATF7 TRIM24 ZSCAN29 CREM RUNX3 CRH PIR59286 GC08P066144 GC08P066139 GC08P066170
GH08H066063 1 Ensembl ENCODE 12.5 +113.9 113895 2 CTCF CEBPG ZNF2 RAD21 CC2D1A CTBP1 GATA3 SMC3 ZNF143 RUNX3 CRH RRS1 RRS1-AS1 ADHFE1 GC08M066089 LOC105375883
GH08H066105 1.1 ENCODE dbSUPER 10.7 +72.9 72865 0.2 HDAC1 ATF1 TBL1XR1 CHAMP1 TCF12 ZNF766 GATA2 FOS ETV6 CREM CRH GC08M066089 TRY-GTA5-1 TRIM55
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRH on UCSC Golden Path with GeneCards custom track

Genomic Locations for CRH Gene

Genomic Locations for CRH Gene
2,349 bases
Minus strand

Genomic View for CRH Gene

Genes around CRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRH Gene

Proteins for CRH Gene

  • Protein details for CRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KQS4

    Protein attributes for CRH Gene

    196 amino acids
    Molecular mass:
    21422 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for CRH Gene

neXtProt entry for CRH Gene

Post-translational modifications for CRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRH Gene

No data available for DME Specific Peptides for CRH Gene

Domains & Families for CRH Gene

Gene Families for CRH Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CRH Gene

Suggested Antigen Peptide Sequences for CRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with CRH: view

Function for CRH Gene

Molecular function for CRH Gene

GENATLAS Biochemistry:
corticotropin releasing hormone
UniProtKB/Swiss-Prot Function:
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

Gene Ontology (GO) - Molecular Function for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7477348
GO:0005179 hormone activity TAS 7585095
GO:0005184 neuropeptide hormone activity TAS 7867564
GO:0005515 protein binding IPI 18234674
GO:0017045 corticotropin-releasing hormone activity IBA --
genes like me logo Genes that share ontologies with CRH: view
genes like me logo Genes that share phenotypes with CRH: view

Animal Models for CRH Gene

MGI Knock Outs for CRH:

miRNA for CRH Gene

miRTarBase miRNAs that target CRH

Clone Products

  • Addgene plasmids for CRH

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRH Gene

Localization for CRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRH Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRH gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 18559919
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body IEA --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with CRH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRH Gene

Pathways & Interactions for CRH Gene

genes like me logo Genes that share pathways with CRH: view

SIGNOR curated interactions for CRH Gene


Gene Ontology (GO) - Biological Process for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IDA 12895416
GO:0006704 glucocorticoid biosynthetic process IEA --
GO:0006954 inflammatory response IDA,IEA 18559919
GO:0007165 signal transduction TAS 7867564
genes like me logo Genes that share ontologies with CRH: view

Drugs & Compounds for CRH Gene

(123) Drugs for CRH Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cocaine Approved, Illicit Pharma 524
Dopamine Approved Pharma Full agonist, Agonist 3926
Hydrocortisone Approved, Vet_approved Pharma Agonist 685
Mifepristone Approved, Investigational Pharma Agonist Progesterone receptor antagonist 164
Corticotropin Approved, Vet_approved Pharma Target, agonist 0

(39) Additional Compounds for CRH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CRH Gene

Compound Action Cas Number
alpha-helical CRF 9-41 CRF receptor antagonist 90880-23-2
CRF (human, rat) Stimulates ACTH release 86784-80-7
Sauvagine CRF agonist 74434-59-6
Urocortin (human) Endogenous CRF agonist 176591-49-4
Urocortin (rat) Endogenous CRF agonist 171543-83-2

(1) ApexBio Compounds for CRH Gene

Compound Action Cas Number
Antisauvagine-30 220673-95-0
genes like me logo Genes that share compounds with CRH: view

Drug Products

Transcripts for CRH Gene

mRNA/cDNA for CRH Gene

Unigene Clusters for CRH Gene

Corticotropin releasing hormone:
Representative Sequences:

Clone Products

  • Addgene plasmids for CRH

Alternative Splicing Database (ASD) splice patterns (SP) for CRH Gene

No ASD Table

Relevant External Links for CRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRH Gene

This gene is overexpressed in Brain - Hypothalamus (x24.8), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for CRH Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRH Gene

Protein tissue co-expression partners for CRH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRH Gene:


SOURCE GeneReport for Unigene cluster for CRH Gene:


mRNA Expression by UniProt/SwissProt for CRH Gene:

Tissue specificity: Produced by the hypothalamus and placenta.

Evidence on tissue expression from TISSUES for CRH Gene

  • Nervous system(4.8)
  • Adrenal gland(4)
  • Blood(2.9)
  • Heart(2.4)
  • Muscle(2.4)
  • Thyroid gland(2.4)
  • Intestine(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CRH Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • ear
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
  • chest wall
  • clavicle
  • esophagus
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
  • adrenal gland
  • intestine
  • large intestine
  • small intestine
  • spleen
  • stomach
  • ovary
  • pelvis
  • penis
  • testicle
  • uterus
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CRH: view

Orthologs for CRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRH 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia CRH 33 34
  • 87.76 (n)
(Mus musculus)
Mammalia Crh 33 16 34
  • 81.82 (n)
(Rattus norvegicus)
Mammalia Crh 33
  • 81.64 (n)
(Bos Taurus)
Mammalia CRH 34
  • 75 (a)
(Monodelphis domestica)
Mammalia CRH 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CRH 34
  • 63 (a)
(Gallus gallus)
Aves CRH 33 34
  • 70.06 (n)
(Anolis carolinensis)
Reptilia CRH 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485597 33
  • 62.05 (n)
(Danio rerio)
Actinopterygii crhb 33 34
  • 62.33 (n)
crha 34
  • 39 (a)
Dr.29164 33
Species where no ortholog for CRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRH Gene

Gene Tree for CRH (if available)
Gene Tree for CRH (if available)

Paralogs for CRH Gene

No data available for Paralogs for CRH Gene

Variants for CRH Gene

Sequence variations from dbSNP and Humsavar for CRH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs748404250 Pathogenic 66,177,389(+) GGACC(C/G)GCCCG reference, missense
rs1000540886 -- 66,175,965(+) TTCTC(A/G)TAGAA downstream-variant-500B
rs1000597555 -- 66,175,895(+) TAGTC(A/T)TTGGA downstream-variant-500B
rs1000650130 -- 66,176,170(+) ATTAT(G/T)AACTC downstream-variant-500B
rs1000726446 -- 66,187,924(+) TCAAA(C/G)ATGTT upstream-variant-2KB

Variation tolerance for CRH Gene

Gene Damage Index Score: 0.75; 15.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRH Gene

Disorders for CRH Gene

MalaCards: The human disease database

(63) MalaCards diseases for CRH Gene - From: HGMD, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
crh-related related nocturnal frontal lobe epilepsy, autosomal dominant
autosomal dominant nocturnal frontal lobe epilepsy
  • epilepsy, nocturnal frontal lobe, 1
post-traumatic stress disorder
  • traumatic neurosis
postpartum depression
  • maternity blues
adrenal carcinoma
  • carcinoma of the adrenal gland
- elite association - COSMIC cancer census association via MalaCards
Search CRH in MalaCards View complete list of genes associated with diseases

Genatlas disease for CRH Gene

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Relevant External Links for CRH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRH: view

No data available for UniProtKB/Swiss-Prot for CRH Gene

Publications for CRH Gene

  1. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck ME … Binder EB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 45 60
  2. A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal neopterygian fish, the spotted gar (Lepisosteus oculatus). (PMID: 25521515) Grone BP … Maruska KP (The Journal of comparative neurology 2015) 2 3 60
  3. Functional characterization of a CRH missense mutation identified in an ADNFLE family. (PMID: 23593457) Sansoni V … Combi R (PloS one 2013) 3 4 60
  4. Association of HPA axis genes with suicidal behaviour in schizophrenia. (PMID: 18838498) De Luca V … Kennedy JL (Journal of psychopharmacology (Oxford, England) 2010) 3 45 60
  5. Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: results from the EPIFUND study. (PMID: 19723618) Holliday KL … McBeth J (Annals of the rheumatic diseases 2010) 3 45 60

Products for CRH Gene

  • Addgene plasmids for CRH

Sources for CRH Gene

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