Aliases for CRH Gene
External Ids for CRH Gene
Previous GeneCards Identifiers for CRH Gene
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]
GeneCards Summary for CRH Gene
CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include autosomal dominant nocturnal frontal lobe epilepsy and crh-related related nocturnal frontal lobe epilepsy, autosomal dominant. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.
UniProtKB/Swiss-Prot for CRH Gene
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.