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Aliases for CRH Gene

Aliases for CRH Gene

  • Corticotropin Releasing Hormone 2 3
  • Corticotropin-Releasing Factor 2 3 4
  • Corticoliberin 2 3
  • CRF 3 4
  • Corticotropin-Releasing Hormone 4
  • CRH1 3

External Ids for CRH Gene

Summaries for CRH Gene

Entrez Gene Summary for CRH Gene

  • Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

GeneCards Summary for CRH Gene

CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include hypoadrenalism and autosomal dominant nocturnal frontal lobe epilepsy. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CRH Gene

  • This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Tocris Summary for CRH Gene

  • Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRH Gene

Genomics for CRH Gene

Genomic Location for CRH Gene

Start:
66,176,377 bp from pter
End:
66,178,725 bp from pter
Size:
2,349 bases
Orientation:
Minus strand

Genomic View for CRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRH Gene

Regulatory Elements for CRH Gene

Proteins for CRH Gene

  • Protein details for CRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06850-CRF_HUMAN
    Recommended name:
    Corticoliberin
    Protein Accession:
    P06850
    Secondary Accessions:
    • B3KQS4

    Protein attributes for CRH Gene

    Size:
    196 amino acids
    Molecular mass:
    21422 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for CRH Gene

neXtProt entry for CRH Gene

Proteomics data for CRH Gene at MOPED

Post-translational modifications for CRH Gene

No Post-translational modifications

Other Protein References for CRH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRH Gene

Domains for CRH Gene

Gene Families for CRH Gene

HGNC:

UniProtKB/Swiss-Prot:

CRF_HUMAN
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.:
    • P06850
genes like me logo Genes that share domains with CRH: view

Function for CRH Gene

Molecular function for CRH Gene

GENATLAS Biochemistry: corticotropin releasing hormone
UniProtKB/Swiss-Prot Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Gene Ontology (GO) - Molecular Function for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7477348
GO:0005179 hormone activity TAS 7585095
GO:0005184 neuropeptide hormone activity TAS 7867564
GO:0005515 protein binding IPI 18234674
GO:0017045 corticotropin-releasing hormone activity IEA --
genes like me logo Genes that share ontologies with CRH: view
genes like me logo Genes that share phenotypes with CRH: view

Animal Models for CRH Gene

MGI Knock Outs for CRH:

miRNA for CRH Gene

miRTarBase miRNAs that target CRH

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CRH Gene

Localization for CRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRH Gene COMPARTMENTS Subcellular localization image for CRH gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18559919
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with CRH: view

Pathways for CRH Gene

genes like me logo Genes that share pathways with CRH: view

Gene Ontology (GO) - Biological Process for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IDA 12895416
GO:0006704 glucocorticoid biosynthetic process IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7867564
genes like me logo Genes that share ontologies with CRH: view

Compounds for CRH Gene

(5) Tocris Compounds for CRH Gene

Compound Action Cas Number
alpha-helical CRF 9-41 CRF receptor antagonist [90880-23-2]
Astressin Potent CRF receptor antagonist [170809-51-5]
CRF (human, rat) Stimulates ACTH release [86784-80-7]
Urocortin (human) Endogenous CRF agonist [176591-49-4]
Urocortin (rat) Endogenous CRF agonist [171543-83-2]

(3) Drugbank Compounds for CRH Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Aminoisobutyric Acid
target
Corticotropin
  • ACTH
9002-60-2 target agonist
D-Phenylalanine
673-06-3 target

(132) Novoseek inferred chemical compound relationships for CRH Gene

Compound -log(P) Hits PubMed IDs
acth 95.3 427
sauvagine 92.1 66
hcrh 91.8 32
astressin 90.4 28
antalarmin 88 23
genes like me logo Genes that share compounds with CRH: view

Transcripts for CRH Gene

mRNA/cDNA for CRH Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRH Gene

Corticotropin releasing hormone:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRH Gene

No ASD Table

Relevant External Links for CRH Gene

GeneLoc Exon Structure for
CRH
ECgene alternative splicing isoforms for
CRH

Expression for CRH Gene

mRNA expression in normal human tissues for CRH Gene

mRNA differential expression in normal tissues according to GTEx for CRH Gene

This gene is overexpressed in Brain - Hypothalamus (24.8), Brain - Anterior cingulate cortex (BA24) (6.0), Brain - Frontal Cortex (BA9) (5.0), and Brain - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRH Gene

SOURCE GeneReport for Unigene cluster for CRH Gene Hs.75294

genes like me logo Genes that share expressions with CRH: view

Orthologs for CRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRH 36
  • 99.66 (n)
  • 100 (a)
CRH 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRH 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRH 36
  • 87.76 (n)
  • 88.27 (a)
CRH 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crh 36
  • 81.82 (n)
  • 78.61 (a)
Crh 16
Crh 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRH 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRH 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crh 36
  • 81.64 (n)
  • 78.07 (a)
chicken
(Gallus gallus)
Aves CRH 36
  • 70.06 (n)
  • 66.47 (a)
CRH 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRH 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485597 36
  • 62.05 (n)
  • 60.24 (a)
zebrafish
(Danio rerio)
Actinopterygii crha 37
  • 39 (a)
OneToMany
crhb 36
  • 62.33 (n)
  • 64.38 (a)
crhb 37
  • 50 (a)
OneToMany
Dr.29164 36
Species with no ortholog for CRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRH Gene

ENSEMBL:
Gene Tree for CRH (if available)
TreeFam:
Gene Tree for CRH (if available)

Paralogs for CRH Gene

No data available for Paralogs for CRH Gene

Variants for CRH Gene

Sequence variations from dbSNP and Humsavar for CRH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6156 -- 66,178,361(-) CAGAG(A/G)AAGCC utr-variant-5-prime
rs6157 -- 66,178,355(-) AAGCC(C/G)CCGGA utr-variant-5-prime
rs6158 -- 66,178,318(-) CACCC(A/G)GCTCA utr-variant-5-prime
rs6159 -- 66,177,190(-) GCCGG(A/C)GGCAG reference, synonymous-codon
rs3176921 -- 66,179,144(-) AGAGA(C/T)TTATT upstream-variant-2KB

Relevant External Links for CRH Gene

HapMap Linkage Disequilibrium report
CRH
Human Gene Mutation Database (HGMD)
CRH

No data available for Structural Variations from Database of Genomic Variants (DGV) for CRH Gene

Disorders for CRH Gene

(91) Novoseek inferred disease relationships for CRH Gene

Disease -log(P) Hits PubMed IDs
cushing syndrome 85.9 101
hypercortisolism 82 39
acth syndrome ectopic 81.2 15
acth deficiency 80.6 6
pituitary-dependent cushings disease 75.2 6

Genatlas disease for CRH Gene

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Relevant External Links for CRH

GeneTests
CRH
GeneReviews
CRH
Genetic Association Database (GAD)
CRH
Human Genome Epidemiology (HuGE) Navigator
CRH
genes like me logo Genes that share disorders with CRH: view

No data available for UniProtKB/Swiss-Prot for CRH Gene

Publications for CRH Gene

  1. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PMID: 11555839) Rosmond R. … BjAPrntorp P. (Metab. Clin. Exp. 2001) 3 23 49
  2. Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PMID: 12734882) Gonzalez-Gay M.A. … Ollier W.E. (J. Rheumatol. 2003) 3 23 49
  3. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S. … Van Broeckhoven C. (Biol. Psychiatry 2003) 3 23 49
  4. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck M.E. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 49
  5. Molecular recognition of corticotropin-releasing factor by its G- protein-coupled receptor CRFR1. (PMID: 18801728) Pioszak A.A. … Xu H.E. (J. Biol. Chem. 2008) 3 4 23

Products for CRH Gene

  • Addgene plasmids for CRH

Sources for CRH Gene

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