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Aliases for CRH Gene

Aliases for CRH Gene

  • Corticotropin Releasing Hormone 2 3
  • Corticotropin-Releasing Factor 2 3 4
  • Corticoliberin 2 3
  • CRF 3 4
  • Corticotropin-Releasing Hormone 4
  • CRH1 3

External Ids for CRH Gene

Previous GeneCards Identifiers for CRH Gene

  • GC08M067028
  • GC08M066811
  • GC08M067138
  • GC08M067251
  • GC08M062579
  • GC08M067088

Summaries for CRH Gene

Entrez Gene Summary for CRH Gene

  • Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

GeneCards Summary for CRH Gene

CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include autosomal dominant nocturnal frontal lobe epilepsy and crh-related related nocturnal frontal lobe epilepsy, autosomal dominant. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CRH Gene

  • This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Tocris Summary for CRH Gene

  • Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRH Gene

Genomics for CRH Gene

Regulatory Elements for CRH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRH Gene

66,176,377 bp from pter
66,178,725 bp from pter
2,349 bases
Minus strand

Genomic View for CRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRH Gene

Proteins for CRH Gene

  • Protein details for CRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KQS4

    Protein attributes for CRH Gene

    196 amino acids
    Molecular mass:
    21422 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for CRH Gene

neXtProt entry for CRH Gene

Proteomics data for CRH Gene at MOPED

Post-translational modifications for CRH Gene

No Post-translational modifications

Other Protein References for CRH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CRH (Pro-Corticoliberin/Pro-CRH)

No data available for DME Specific Peptides for CRH Gene

Domains for CRH Gene

Gene Families for CRH Gene

Suggested Antigen Peptide Sequences for CRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with CRH: view

Function for CRH Gene

Molecular function for CRH Gene

GENATLAS Biochemistry:
corticotropin releasing hormone
UniProtKB/Swiss-Prot Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Gene Ontology (GO) - Molecular Function for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7477348
GO:0005179 hormone activity TAS 7585095
GO:0005184 neuropeptide hormone activity TAS 7867564
GO:0005515 protein binding IPI 18234674
GO:0017045 corticotropin-releasing hormone activity IEA --
genes like me logo Genes that share ontologies with CRH: view
genes like me logo Genes that share phenotypes with CRH: view

Animal Models for CRH Gene

MGI Knock Outs for CRH:

Animal Model Products

miRNA for CRH Gene

miRTarBase miRNAs that target CRH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRH Gene

Localization for CRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRH Gene


Subcellular locations from

Jensen Localization Image for CRH Gene COMPARTMENTS Subcellular localization image for CRH gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18559919
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with CRH: view

Pathways for CRH Gene

genes like me logo Genes that share pathways with CRH: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Neurotrophins & Receptors in human,mouse,rat
    • Obesity in human,mouse,rat

Gene Ontology (GO) - Biological Process for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IDA 12895416
GO:0006704 glucocorticoid biosynthetic process IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7867564
genes like me logo Genes that share ontologies with CRH: view

Drugs for CRH Gene

(3) Drugbank Compounds for CRH Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • ACTH
9002-60-2 Target agonist approved
Alpha-Aminoisobutyric Acid
6119 Target experimental
673-06-3 Target experimental

(5) Tocris Compounds for CRH Gene

Compound Action Cas Number
alpha-helical CRF 9-41 CRF receptor antagonist [90880-23-2]
Astressin Potent CRF receptor antagonist [170809-51-5]
CRF (human, rat) Stimulates ACTH release [86784-80-7]
Urocortin (human) Endogenous CRF agonist [176591-49-4]
Urocortin (rat) Endogenous CRF agonist [171543-83-2]

(132) Novoseek inferred chemical compound relationships for CRH Gene

Compound -log(P) Hits PubMed IDs
acth 95.3 427
sauvagine 92.1 66
hcrh 91.8 32
astressin 90.4 28
antalarmin 88 23
genes like me logo Genes that share compounds with CRH: view

Transcripts for CRH Gene

mRNA/cDNA for CRH Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRH Gene

Corticotropin releasing hormone:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRH Gene

No ASD Table

Relevant External Links for CRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRH Gene

mRNA expression in normal human tissues for CRH Gene

mRNA differential expression in normal tissues according to GTEx for CRH Gene

This gene is overexpressed in Brain - Hypothalamus (24.8), Brain - Anterior cingulate cortex (BA24) (6.0), Brain - Frontal Cortex (BA9) (5.0), and Brain - Cortex (4.6).

Protein differential expression in normal tissues for CRH Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRH Gene

SOURCE GeneReport for Unigene cluster for CRH Gene Hs.75294

genes like me logo Genes that share expressions with CRH: view

Expression partners for CRH Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRH Gene

Orthologs for CRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRH Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CRH 35
  • 87.76 (n)
  • 88.27 (a)
CRH 36
  • 88 (a)
(Mus musculus)
Mammalia Crh 35
  • 81.82 (n)
  • 78.61 (a)
Crh 16
Crh 36
  • 78 (a)
(Pan troglodytes)
Mammalia CRH 35
  • 99.66 (n)
  • 100 (a)
CRH 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Crh 35
  • 81.64 (n)
  • 78.07 (a)
(Bos Taurus)
Mammalia CRH 36
  • 75 (a)
(Monodelphis domestica)
Mammalia CRH 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CRH 36
  • 63 (a)
(Gallus gallus)
Aves CRH 35
  • 70.06 (n)
  • 66.47 (a)
CRH 36
  • 65 (a)
(Anolis carolinensis)
Reptilia CRH 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485597 35
  • 62.05 (n)
  • 60.24 (a)
(Danio rerio)
Actinopterygii crhb 35
  • 62.33 (n)
  • 64.38 (a)
Dr.29164 35
crha 36
  • 39 (a)
crhb 36
  • 50 (a)
Species with no ortholog for CRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRH Gene

Gene Tree for CRH (if available)
Gene Tree for CRH (if available)

Paralogs for CRH Gene

No data available for Paralogs for CRH Gene

Variants for CRH Gene

Sequence variations from dbSNP and Humsavar for CRH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs377389763 -- 66,178,367(+) CTCTG(A/G)AGGTT utr-variant-5-prime
rs376533072 -- 66,180,583(+) ATTAA(C/T)AGAGC upstream-variant-2KB
rs376401172 -- 66,178,175(+) CACAC(-/ACAC)GCACG intron-variant
rs375924482 -- 66,178,610(+) GGAAC(A/G)AGGGG utr-variant-5-prime
rs375820609 -- 66,178,474(+) CCAGA(A/G)CCTGG utr-variant-5-prime

Relevant External Links for CRH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRH Gene

Disorders for CRH Gene

(91) Novoseek inferred disease relationships for CRH Gene

Disease -log(P) Hits PubMed IDs
cushing syndrome 85.9 101
hypercortisolism 82 39
acth syndrome ectopic 81.2 15
acth deficiency 80.6 6
pituitary-dependent cushings disease 75.2 6

Genatlas disease for CRH Gene

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Relevant External Links for CRH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CRH: view

No data available for OMIM and UniProtKB/Swiss-Prot for CRH Gene

Publications for CRH Gene

  1. A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PMID: 11555839) Rosmond R. … BjAPrntorp P. (Metab. Clin. Exp. 2001) 3 23 48
  2. Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PMID: 12734882) Gonzalez-Gay M.A. … Ollier W.E. (J. Rheumatol. 2003) 3 23 48
  3. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PMID: 14573312) Claes S. … Van Broeckhoven C. (Biol. Psychiatry 2003) 3 23 48
  4. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck M.E. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23 48
  5. Molecular recognition of corticotropin-releasing factor by its G- protein-coupled receptor CRFR1. (PMID: 18801728) Pioszak A.A. … Xu H.E. (J. Biol. Chem. 2008) 3 4 23

Products for CRH Gene

  • Addgene plasmids for CRH

Sources for CRH Gene

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