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Aliases for CRH Gene

Aliases for CRH Gene

  • Corticotropin Releasing Hormone 2 3
  • Corticotropin-Releasing Factor 2 3 4
  • CRF 3 4
  • Corticotropin-Releasing Hormone 4
  • Corticoliberin 2
  • CRH1 3

External Ids for CRH Gene

Previous GeneCards Identifiers for CRH Gene

  • GC08M067028
  • GC08M066811
  • GC08M067138
  • GC08M067251
  • GC08M062579
  • GC08M067088

Summaries for CRH Gene

Entrez Gene Summary for CRH Gene

  • This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

GeneCards Summary for CRH Gene

CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include crh-related related nocturnal frontal lobe epilepsy, autosomal dominant and autosomal dominant nocturnal frontal lobe epilepsy. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CRH Gene

  • This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Tocris Summary for CRH Gene

  • Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRH Gene

Genomics for CRH Gene

Regulatory Elements for CRH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRH Gene

66,176,377 bp from pter
66,178,725 bp from pter
2,349 bases
Minus strand

Genomic View for CRH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRH Gene

Proteins for CRH Gene

  • Protein details for CRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KQS4

    Protein attributes for CRH Gene

    196 amino acids
    Molecular mass:
    21422 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for CRH Gene

neXtProt entry for CRH Gene

Proteomics data for CRH Gene at MOPED

Post-translational modifications for CRH Gene

No Post-translational modifications

Other Protein References for CRH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CRH (Pro-Corticoliberin/Pro-CRH)

No data available for DME Specific Peptides for CRH Gene

Domains & Families for CRH Gene

Gene Families for CRH Gene

Protein Domains for CRH Gene

Suggested Antigen Peptide Sequences for CRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with CRH: view

Function for CRH Gene

Molecular function for CRH Gene

GENATLAS Biochemistry:
corticotropin releasing hormone
UniProtKB/Swiss-Prot Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Gene Ontology (GO) - Molecular Function for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7477348
GO:0005179 hormone activity TAS 7585095
GO:0005184 neuropeptide hormone activity TAS 7867564
GO:0005515 protein binding IPI 18234674
GO:0051430 corticotropin-releasing hormone receptor 1 binding IEA --
genes like me logo Genes that share ontologies with CRH: view
genes like me logo Genes that share phenotypes with CRH: view

Animal Models for CRH Gene

MGI Knock Outs for CRH:

Animal Model Products

miRNA for CRH Gene

miRTarBase miRNAs that target CRH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRH Gene

Localization for CRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRH Gene


Subcellular locations from

Jensen Localization Image for CRH Gene COMPARTMENTS Subcellular localization image for CRH gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18559919
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with CRH: view

Pathways & Interactions for CRH Gene

genes like me logo Genes that share pathways with CRH: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Neurotrophins & Receptors in human,mouse,rat
    • Obesity in human,mouse,rat

SIGNOR curated interactions for CRH Gene


Gene Ontology (GO) - Biological Process for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IDA 12895416
GO:0006704 glucocorticoid biosynthetic process IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7867564
genes like me logo Genes that share ontologies with CRH: view

Drugs & Compounds for CRH Gene

(96) Drugs for CRH Gene - From: NovoSeek, DrugBank, ClinicalTrials, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cocaine Approved, Illicit Pharma 441
Hydrocortisone Approved Pharma Agonist 550
Mifepristone Approved, Investigational Pharma Antagonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 132
Corticotropin Approved Pharma Target, agonist 0
Alprazolam Approved, Illicit, Investigational Pharma 64

(49) Additional Compounds for CRH Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-helical CRF 9-41
CRF (human, rat)
Urocortin (human)
Urocortin (rat)
11 deoxycortisol
genes like me logo Genes that share compounds with CRH: view

Transcripts for CRH Gene

mRNA/cDNA for CRH Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRH Gene

Corticotropin releasing hormone:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRH Gene

No ASD Table

Relevant External Links for CRH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRH Gene

mRNA expression in normal human tissues for CRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRH Gene

This gene is overexpressed in Brain - Hypothalamus (x24.8), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for CRH Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRH Gene

SOURCE GeneReport for Unigene cluster for CRH Gene Hs.75294

genes like me logo Genes that share expression patterns with CRH: view

Protein tissue co-expression partners for CRH Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CRH Gene

Orthologs for CRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRH Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CRH 35
  • 87.76 (n)
  • 88.27 (a)
CRH 36
  • 88 (a)
(Mus musculus)
Mammalia Crh 35
  • 81.82 (n)
  • 78.61 (a)
Crh 16
Crh 36
  • 78 (a)
(Pan troglodytes)
Mammalia CRH 35
  • 99.66 (n)
  • 100 (a)
CRH 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Crh 35
  • 81.64 (n)
  • 78.07 (a)
(Bos Taurus)
Mammalia CRH 36
  • 75 (a)
(Monodelphis domestica)
Mammalia CRH 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CRH 36
  • 63 (a)
(Gallus gallus)
Aves CRH 35
  • 70.06 (n)
  • 66.47 (a)
CRH 36
  • 65 (a)
(Anolis carolinensis)
Reptilia CRH 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485597 35
  • 62.05 (n)
  • 60.24 (a)
(Danio rerio)
Actinopterygii crhb 35
  • 62.33 (n)
  • 64.38 (a)
Dr.29164 35
crha 36
  • 39 (a)
crhb 36
  • 50 (a)
Species with no ortholog for CRH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRH Gene

Gene Tree for CRH (if available)
Gene Tree for CRH (if available)

Paralogs for CRH Gene

No data available for Paralogs for CRH Gene

Variants for CRH Gene

Sequence variations from dbSNP and Humsavar for CRH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6156 -- 66,178,361(-) CAGAG(A/G)AAGCC utr-variant-5-prime
rs6157 -- 66,178,355(-) AAGCC(C/G)CCGGA utr-variant-5-prime
rs6158 -- 66,178,318(-) CACCC(A/G)GCTCA utr-variant-5-prime
rs6159 -- 66,177,190(-) GCCGG(A/C)GGCAG reference, synonymous-codon
rs3176921 -- 66,179,144(-) AGAGA(C/T)TTATT upstream-variant-2KB

Variation tolerance for CRH Gene

Gene Damage Index Score: 0.75; 15.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRH Gene

Disorders for CRH Gene

MalaCards: The human disease database

(58) MalaCards diseases for CRH Gene - From: ClinVar, GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
crh-related related nocturnal frontal lobe epilepsy, autosomal dominant
autosomal dominant nocturnal frontal lobe epilepsy
  • epilepsy, nocturnal frontal lobe, 1
adrenal carcinoma
  • carcinoma of the adrenal gland
postpartum depression
  • postnatal depression
- elite association
Search CRH in MalaCards View complete list of genes associated with diseases

Genatlas disease for CRH Gene

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Relevant External Links for CRH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CRH: view

No data available for UniProtKB/Swiss-Prot for CRH Gene

Publications for CRH Gene

  1. Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro. (PMID: 16523405) Wagner U. … Baerwald C.G. (Horm. Metab. Res. 2006) 23 25 67
  2. Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity. (PMID: 16534240) Matejec R. … Teschemacher H. (Neuroendocrinology 2005) 23 25 67
  3. A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal neopterygian fish, the spotted gar (Lepisosteus oculatus). (PMID: 25521515) Grone B.P. … Maruska K.P. (J. Comp. Neurol. 2015) 2 67
  4. Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction. (PMID: 19891960) Borgland S.L. … Bonci A. (Brain Res. 2010) 23 67
  5. Sexually diergic, dose-dependent hypothalamic-pituitary-adrenal axis responses to nicotine in a dynamic in vitro perfusion system. (PMID: 20117222) McKlveen J.M. … Rhodes M.E. (J Pharmacol Toxicol Methods 2010) 23 67

Products for CRH Gene

Sources for CRH Gene

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