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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRH Gene

protein-coding GIFtS: 61
GCID: GC08M067088

corticotropin releasing hormone

Explore 168 diseases affiliated with
CRH via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Corticotropin Releasing Hormone¹ ²
CRF¹ ² ³
Corticotropin-Releasing Factor² ³
Corticoliberin¹
Corticotropin-Releasing Hormone³

External Ids:	HGNC: 2355¹	Entrez Gene: 1392²	Ensembl: ENSG00000147571⁷	OMIM: 122560⁵	UniProtKB: P06850³

Export aliases for CRH gene to outside databases

Previous GC identifers: GC08M066208 GC08M067028 GC08M066811 GC08M067138 GC08M067251 GC08M062579

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRH:

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to

stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal

recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including

hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in

peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that

determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels

of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this

protein may act as a trigger for parturition. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850

Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

summary for CRH:

Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of

homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been

suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned

from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified

in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH (Corticotropin-releasing hormone)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRH gene promoter:
AP-1 ATF-2 NRSF form 1 NF-kappaB NRSF form 2 CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRH promoter sequence

Search SABiosciences Chromatin IP Primers for CRH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13

CRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRH gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M067088: view genomic region (about GC identifiers)

Start:	67,088,612 bp from pter	End:	67,090,960 bp from pter
Size:	2,349 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850 (See protein sequence)

Recommended Name: Corticoliberin precursor

Size: 196 amino acids; 21422 Da

Subunit: Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain)

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for CRH:

3EHT (3D)

3EHU (3D)

Secondary accessions: B3KQS4

Explore the universe of human proteins at neXtProt for CRH: NX_P06850

CRH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000747.1

ENSEMBL proteins:

ENSP00000276571

Reactome Protein details: P06850
Human Recombinant Protein Products for CRH:

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	Uscn Proteins for CRH

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	18559919
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IEA	--
GO:0043196	varicosity	IEA	--

CRH for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CRH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRH for domains About GeneDecksing

3 InterPro domains/families:

IPR018446 Corticotropin-releasing_fac_CS

IPR000187 Corticotropin-releasing_factor

IPR003620 Urocortin_CRF

Graphical View of Domain Structure for InterPro Entry P06850

ProtoNet protein and cluster: P06850

1 Blocks protein family: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850

Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CRF_HUMAN, P06850

Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland

Genatlas biochemistry entry for CRH:

corticotropin releasing hormone

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	7477348
GO:0005179	hormone activity	TAS	7585095
GO:0005184	neuropeptide hormone activity	TAS	7867564
GO:0005515	protein binding	IPI	18801728
GO:0017045	corticotropin-releasing hormone activity	IEA	--

CRH for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crh):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	nervous system	normal
other	respiratory system

CRH for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Crh^tm1Maj for CRH

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRH

miRNA Products:		OriGene 3'-UTR Clone: CRH Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
		hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
		SwitchGear 3'UTR luciferase reporter plasmid: CRH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRH (see all 7) OriGene shRNA RFP: CRH OriGene siRNA: CRH
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRH (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

Long-term depression

Long-term depression

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CRH

Selected targets of CREB1

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRH

CRHR Pathway

2 BioSystems Pathways for CRH

	Myometrial Relaxation and Contraction Pathways
	Rapid glucocorticoid signaling

5/6 Reactome Pathways for CRH (see all 6)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

1 PharmGKB Pathway for CRH

Glucocorticoid Pathway (HPA Axis), Pharmacodynamics

1 Kegg Pathway (Kegg details for CRH):

Long-term depression

CRH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRH

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for CRH (P06850^{1, 3} ENSP00000276571⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRHR1	P34998¹^,³, ENSP00000381333⁴	EBI-3870390,EBI-3870393 I2D: score=2 STRING: ENSP00000381333
CRHR2	Q13324³	I2D: score=2
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361
ADCY6	ENSP00000311405⁴	STRING: ENSP00000311405

About this table

Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001934	positive regulation of protein phosphorylation	IEA	--
GO:0001963	synaptic transmission, dopaminergic	IDA	12895416
GO:0006704	glucocorticoid biosynthetic process	IEA	--
GO:0006950	response to stress	--	--
GO:0006954	inflammatory response	IDA	18559919

CRH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CRH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CRH available from Tocris Bioscience About this table

Compound	Action	CAS #
NBI 27914 hydrochloride	Selective non-peptide CRF1 antagonist	[184241-44-9]
Astressin 2B	Selective CRF2 antagonist	[681260-70-8]
Sauvagine	CRF agonist	[74434-59-6]
alpha-helical CRF 9-41	CRF receptor antagonist	--
Astressin	Potent CRF receptor antagonist	[170809-51-5]

3 DrugBank Compounds for CRH About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Corticotropin	ACTH (see all 5)	9002-60-2	target	agonist	16503922 16534240 16472586 16467980 16523405
Alpha-Aminoisobutyric Acid	--	--	target	--	10592235
D-Phenylalanine	--	673-06-3	target	--	10592235

10/132 Novoseek chemical compound relationships for CRH gene (see all 132) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acth	95.3	2061	11380490 (9), 1983217 (8), 9274696 (7), 9841549 (7) (see all 99)
sauvagine	92.1	130	9326293 (3), 8822168 (3), 9612279 (3), 10777063 (3) (see all 48)
hcrh	91.8	44	1651955 (2), 7675936 (1), 10843178 (1), 17186287 (1) (see all 31)
astressin	90.4	38	9030428 (2), 12679466 (2), 11902119 (2), 17568667 (2) (see all 23)
antalarmin	88	31	9629233 (2), 10822340 (2), 15916629 (2), 10456290 (1) (see all 20)
dexamethasone	78.8	477	15950349 (9), 17825799 (7), 8386285 (6), 18926641 (6) (see all 99)
metyrapone	72.4	69	2155255 (5), 1473519 (4), 7970937 (3), 7753338 (3) (see all 26)
corticosterone	71.9	137	20308419 (3), 1319007 (3), 11959675 (3), 2156674 (3) (see all 63)
arginine	66.5	249	17566099 (4), 7895915 (2), 20368512 (2), 1658546 (2) (see all 99)
pivagabine	62	4	9450153 (1), 9450157 (1)

Search CenterWatch for drugs/clinical trials and news about CRH / CRF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRH gene:

NM_000756.2

Unigene Cluster for CRH:

Corticotropin releasing hormone

Hs.75294 [show with all ESTs]

Unigene Representative Sequence: NM_000756

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000276571(uc003xvy.2)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRH
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CRH:
		hsa-miR-498 hsa-miR-4307 hsa-miR-466 hsa-miR-548s hsa-miR-3941 hsa-miR-2113
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRH

Additional cDNA sequence:

AK075431.1 BC002599.2 BC011031.1 BT007453.1

4 DOTS entries:

DT.213036 DT.92426756 DT.100682388 DT.97842166

24/118 AceView cDNA sequences (see all 118):

CR592854 CA774731 CR625216 NM_000756 BX104521 CA442822 BQ023511 CA774978

BF196912 BQ026679 F03116 CR619891 CR603754 AI160513 CR626513 AK075431

AW513134 CR617485 BQ026511 F05084 BC002599 BX345878 BG572446 CB961608

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CRH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Early limb mesenchymal cells (ELM cells) (Primary Cell)

Bone, Cartilage, Limb

Syncytiotrophoblast-like cells (Generation of syncyt...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CRH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRH

SOURCE GeneReport for Unigene cluster: Hs.75294

SABiosciences Expression via Pathway-Focused PCR Arrays including CRH:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Neurotrophins & Receptors in human mouse rat

Obesity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRH Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CRH gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crh^{1 , 5}	corticotropin releasing hormone^{1, 5}	83.6(n)¹ 82.35(a)¹		3 (5.75 cM)⁵ 12918¹ NM_205769.2¹ NP_991338.1¹ 19693401⁵
chicken (Gallus gallus)	Aves	CRH¹	corticotropin releasing hormone	71.29(n) 68.07(a)		404297 NM_001123031.1 NP_001116503.1
lizard (Anolis carolinensis)	Reptilia	CRH⁶	--	56(a)	1 ↔ 1	4(30730518-30731126)
zebrafish (Danio rerio)	Actinopterygii	Dr.29164²	Transcribed sequence with moderate similarity to protein more	76.98(n)		AL923634.1

ENSEMBL Gene Tree for CRH (if available)
TreeFam Gene Tree for CRH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80126712^1,2	C,F	--	62578361(+)	`TAGAAA/GAAGAA`	1	--	ds500¹		1	WA	118
rs6982394^1,2	C,F,H	--	62578632(+)	`AGCCAC/ATGACA`	1	--	ds500¹		15	NS EA NA CSA WA	1892
rs7459924^1,2	H	--	62579100(+)	`CACGTG/CAATAC`	1	--	ut3¹ ese³		4	NS EA	420
rs72556398^1,2	C	--	62579817(-)	`CTCCTG/CCCCTG`	2	/L	syn¹		1	--	64
rs12721511^1,2	C,H	--	62579864(-)	`ACATGC/GGGCTG`	2	R G	mis¹ ese³		5	NS EA	514
rs112962684^1,2		--	62579940(+)	`AAGAGC/TTGGTT`	1	--	int¹		1	CSA	2
rs78644517^1,2	F	--	62580003(+)	`AGACGT/GGCTGG`	1	--	int¹		1	WA	118
rs28364018^1,2	C,F,H	--	62580025(-)	`TCCGAA/CTCACT`	1	--	int¹		15	NS EA WA NA	2938
rs76878322^1,2	C,F	--	62580145(+)	`AGACTC/TTGAAA`	1	--	int¹		1	WA	118
rs73693933^1,2	C	--	62580463(+)	`TTGTAA/CTCTTA`	1	--	int¹		2	WA	120

HapMap Linkage Disequilibrium report for CRH (67088612 - 67090960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRH: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRH

DNA2.0 Custom Variant and Variant Library Synthesis for CRH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRH for disorders           About GeneDecksing

OMIM gene information: 122560    OMIM disorders: --

20/168 diseases for CRH (see all 168):    About MalaCards

autosomal dominant nocturnal frontal lobe epilepsy frontal lobe epilepsy post-traumatic stress disorder pituitary-dependent cushing's disease

hypoglycemia 21-hydroxylase deficiency alzheimer's disease spinal cord injury

seasonal affective disorder eosinophilia-myalgia syndrome obsessive-compulsive disorder growth hormone deficiency

langerhans-cell histiocytosis neurohypophyseal diabetes insipidus adrenocorticotropic hormone deficiency pituitary hormone deficiency

acth deficiency combined pituitary hormone deficiency isolated acth deficiency adrenal hyperplasia

18 diseases from the University of Copenhagen DISEASES database for CRH:

Cushing's syndrome Irritable bowel syndrome pituitary-dependent Cushing's disease Nelson syndrome

Anxiety disorder Pituitary adenoma Adenoma Hypoglycemia

Alcohol dependence Addison's disease Hypopituitarism Pain agnosia

Substance abuse Hypertension Adrenal adenoma Melancholia

Endogenous depression Drug dependence

10/91 Novoseek disease relationships for CRH gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cushing syndrome	85.9	141	7641409 (5), 7891545 (4), 17039427 (3), 1597149 (3) (see all 66)
hypercortisolism	82	50	9696732 (2), 16478558 (2), 9238254 (2), 8097579 (2) (see all 31)
acth syndrome ectopic	81.2	23	8254033 (4), 7958079 (3), 9274696 (1), 11729609 (1) (see all 10)
acth deficiency	80.6	6	8882784 (2), 1660365 (1), 1313844 (1), 9152624 (1) (see all 5)
pituitary-dependent cushings disease	75.2	8	8157708 (1), 1848486 (1), 7891545 (1), 2178536 (1) (see all 6)
major depression	71.3	127	16478558 (3), 19846118 (2), 9893154 (2), 17825799 (2) (see all 70)
hypercortisolemia	66.3	6	11086823 (1), 1651955 (1), 18406750 (1), 12679470 (1)
mood disorders	62.9	57	15705605 (4), 11337098 (2), 9662725 (2), 12438692 (1) (see all 38)
pituitary adenoma	62.2	24	15829152 (2), 7958079 (2), 8254033 (2), 8386895 (1) (see all 15)
anxiety disorders	61.7	64	16594259 (3), 8491091 (2), 9854171 (2), 10599479 (2) (see all 36)

Genatlas disease: CRH

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

GeneTests: CRH

Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant

Genetic Association Database (GAD): CRH
Human Genome Epidemiology (HuGE) Navigator: CRH (56 documents)

Export disorders for CRH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRH gene, integrated from 9 sources (see all 1942):
(articles sorted by number of sources associating them with CRH)

Utopia: connect your pdf to the dynamic
world of online information

Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. (PubMed id 18801728)^{1, 2, 9} Pioszak A.A....Xu H.E. (2008)
Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PubMed id 12734882)^{1, 4, 9} Gonzalez-Gay M.A....Ollier W.E. (2003)
Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro. (PubMed id 16523405)^{1, 7, 9} Wagner U....Baerwald C.G. (2006)
The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)^{1, 4, 9} Claes S....Van Broeckhoven C. (2003)
A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PubMed id 11555839)^{1, 4, 9} Rosmond R....Bjorntorp P. (2001)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. (PubMed id 12154211)^{1, 4} Donn R.P....Thomson W. (2002)
Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. (PubMed id 12051390)^{1, 4} Gonzalez-Gay M.A....Ollier W.E. (2002)
Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. (PubMed id 8386360)^{1, 2} Romier C.... Darbon H. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1392	HGNC: 2355	AceView: CRH	Ensembl:ENSG00000147571	euGenes: HUgn1392
ECgene: CRH	Kegg: 1392	H-InvDB: CRH

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRH	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone

Intellectual Property for CRH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRH gene:
Search GeneIP for patents involving CRH

Licensable Technologies for CRH gene:

Salk Institute:

Corticotropin Releasing Factor-Binding Protein (CRF-BP)

(see all 2)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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corticotropin releasing hormone

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Menstrual migraine
preterm delivery
hypercortisolemia
Anxiety Disorders
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social stress
ADRENAL DYSFUNCTION
MOOD CHANGE
anxiety depression
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major depressive episode
Inflammation
ACTH Syndrome Ectopic
adrenal hyperplasia
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psychiatric disorder
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hormone deficiency
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hypofunction
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insulin tolerance
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clinical depression
ACTH DEFICIENCY
Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant
VIRILIZATION
Acromegaly
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Polycystic Ovary Syndrome
Depression Postpartum
Infantile spasms
ADRENAL TUMOR
Cocaine Addiction
ADRENAL ADENOMA
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Fibromyalgia
Dementia Multi-Infarct
Labor Premature
Functional gastrointestinal disorder
Nelson Syndrome
HYPOADRENALISM
Hypogonadism
Choriocarcinoma

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CRH Gene

corticotropin releasing hormone

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