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Aliases for CRH Gene

Aliases for CRH Gene

  • Corticotropin Releasing Hormone 2 3 5
  • Corticotropin-Releasing Factor 2 3 4
  • Corticoliberin 2 3
  • CRF 3 4
  • Corticotropin-Releasing Hormone 4
  • CRH1 3

External Ids for CRH Gene

Previous GeneCards Identifiers for CRH Gene

  • GC08M067028
  • GC08M066811
  • GC08M067138
  • GC08M067251
  • GC08M062579
  • GC08M067088

Summaries for CRH Gene

Entrez Gene Summary for CRH Gene

  • This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

GeneCards Summary for CRH Gene

CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include Autosomal Dominant Nocturnal Frontal Lobe Epilepsy and Crh-Related Related Nocturnal Frontal Lobe Epilepsy, Autosomal Dominant. Among its related pathways are Circadian rythm related genes and Presynaptic function of Kainate receptors. GO annotations related to this gene include receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CRH Gene

  • Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

Tocris Summary for CRH Gene

  • Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Gene Wiki entry for CRH Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRH Gene

Genomics for CRH Gene

Regulatory Elements for CRH Gene

Enhancers for CRH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G066118 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +53.8 53808 13.0 PKNOX1 FOXA2 SIN3A FEZF1 YY1 FOS MCM3 JUNB ZNF592 ZNF579 C8orf44 CRH GC08P066139 GC08P066135 PIR59286 GC08P066170
GH08G066141 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +36.2 36235 2.2 ATF1 ARNT TCF12 GATA2 NCOA1 ZNF592 MEF2D MBD2 SMARCA4 MYNN TRY-GTA5-1 CRH ADHFE1 RRS1-AS1 RRS1 LINC00967 PIR59286 GC08P066170 GC08P066139 GC08P066135
GH08G066131 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +45.7 45659 2.2 CTCF CEBPB CEBPG ATF2 IRF9 TRIM24 ZSCAN29 CREM CRH PIR59286 GC08P066139 GC08P066135 GC08P066170
GH08G066157 1.1 ENCODE dbSUPER 12.2 +20.7 20696 4.2 PKNOX1 FOXA2 ZSCAN4 ARID4B RARA TCF12 TBX21 NFIL3 CEBPA FOXJ2 CRH TRIM55 LINC00967 GC08P066170 PIR59286 GC08P066135 GC08P066139
GH08G066151 1.1 dbSUPER 11.6 +26.3 26289 1.1 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 C8orf44 CSPP1 CRH TRIM55 ARMC1 LINC00967 GC08P066170 PIR59286 GC08P066139 GC08P066135
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRH on UCSC Golden Path with GeneCards custom track

Genomic Location for CRH Gene

Chromosome:
8
Start:
66,176,377 bp from pter
End:
66,178,725 bp from pter
Size:
2,349 bases
Orientation:
Minus strand

Genomic View for CRH Gene

Genes around CRH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRH Gene

Proteins for CRH Gene

  • Protein details for CRH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06850-CRF_HUMAN
    Recommended name:
    Corticoliberin
    Protein Accession:
    P06850
    Secondary Accessions:
    • B3KQS4

    Protein attributes for CRH Gene

    Size:
    196 amino acids
    Molecular mass:
    21422 Da
    Quaternary structure:
    • Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for CRH Gene

neXtProt entry for CRH Gene

Post-translational modifications for CRH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRH Gene

Antibody Products

  • R&D Systems Antibodies for CRH (Pro-Corticoliberin/Pro-CRH)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CRH

No data available for DME Specific Peptides for CRH Gene

Domains & Families for CRH Gene

Gene Families for CRH Gene

Protein Domains for CRH Gene

Suggested Antigen Peptide Sequences for CRH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06850

UniProtKB/Swiss-Prot:

CRF_HUMAN :
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Family:
  • Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
genes like me logo Genes that share domains with CRH: view

Function for CRH Gene

Molecular function for CRH Gene

GENATLAS Biochemistry:
corticotropin releasing hormone
UniProtKB/Swiss-Prot Function:
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).

Gene Ontology (GO) - Molecular Function for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7477348
GO:0005179 hormone activity TAS 7585095
GO:0005184 neuropeptide hormone activity TAS 7867564
GO:0005515 protein binding IPI 18234674
GO:0017045 corticotropin-releasing hormone activity IBA --
genes like me logo Genes that share ontologies with CRH: view
genes like me logo Genes that share phenotypes with CRH: view

Animal Models for CRH Gene

MGI Knock Outs for CRH:

Animal Model Products

miRNA for CRH Gene

miRTarBase miRNAs that target CRH

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRH

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRH Gene

Localization for CRH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRH gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
mitochondrion 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18559919
GO:0005737 cytoplasm IEA --
GO:0043025 neuronal cell body IEA --
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with CRH: view

Pathways & Interactions for CRH Gene

genes like me logo Genes that share pathways with CRH: view

SIGNOR curated interactions for CRH Gene

Activates:

Gene Ontology (GO) - Biological Process for CRH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0001963 synaptic transmission, dopaminergic IDA 12895416
GO:0006704 glucocorticoid biosynthetic process IEA --
GO:0006954 inflammatory response IDA 18559919
GO:0007165 signal transduction TAS 7867564
genes like me logo Genes that share ontologies with CRH: view

Drugs & Compounds for CRH Gene

(120) Drugs for CRH Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cocaine Approved, Illicit Pharma 511
Dopamine Approved Pharma Full agonist, Agonist 3836
Hydrocortisone Approved, Vet_approved Pharma Agonist Adrenal glucocorticoid; immunosuppressant 667
Mifepristone Approved, Investigational Pharma Agonist Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 155
Corticotropin Approved, Vet_approved Pharma Target, agonist 0

(42) Additional Compounds for CRH Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-helical CRF 9-41
90880-23-2

(5) Tocris Compounds for CRH Gene

Compound Action Cas Number
alpha-helical CRF 9-41 CRF receptor antagonist 90880-23-2
Astressin Potent CRF receptor antagonist 170809-51-5
CRF (human, rat) Stimulates ACTH release 86784-80-7
Urocortin (human) Endogenous CRF agonist 176591-49-4
Urocortin (rat) Endogenous CRF agonist 171543-83-2

(1) ApexBio Compounds for CRH Gene

Compound Action Cas Number
Antisauvagine-30 220673-95-0
genes like me logo Genes that share compounds with CRH: view

Drug Products

Transcripts for CRH Gene

mRNA/cDNA for CRH Gene

Unigene Clusters for CRH Gene

Corticotropin releasing hormone:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CRH

Alternative Splicing Database (ASD) splice patterns (SP) for CRH Gene

No ASD Table

Relevant External Links for CRH Gene

GeneLoc Exon Structure for
CRH
ECgene alternative splicing isoforms for
CRH

Expression for CRH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRH Gene

This gene is overexpressed in Brain - Hypothalamus (x24.8), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for CRH Gene

This gene is overexpressed in Placenta (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRH Gene



Protein tissue co-expression partners for CRH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRH Gene:

CRH

SOURCE GeneReport for Unigene cluster for CRH Gene:

Hs.75294

mRNA Expression by UniProt/SwissProt for CRH Gene:

P06850-CRF_HUMAN
Tissue specificity: Produced by the hypothalamus and placenta.

Evidence on tissue expression from TISSUES for CRH Gene

  • Nervous system(4.8)
  • Adrenal gland(4)
  • Blood(2.9)
  • Heart(2.4)
  • Muscle(2.4)
  • Thyroid gland(2.4)
  • Intestine(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CRH Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • ear
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • pituitary gland
  • skull
Thorax:
  • chest wall
  • clavicle
  • esophagus
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • adrenal gland
  • intestine
  • large intestine
  • small intestine
  • spleen
  • stomach
Pelvis:
  • ovary
  • pelvis
  • penis
  • testicle
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CRH: view

Primer Products

Orthologs for CRH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRH 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia CRH 34 35
  • 87.76 (n)
mouse
(Mus musculus)
Mammalia Crh 34 16 35
  • 81.82 (n)
rat
(Rattus norvegicus)
Mammalia Crh 34
  • 81.64 (n)
cow
(Bos Taurus)
Mammalia CRH 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRH 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRH 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRH 34 35
  • 70.06 (n)
lizard
(Anolis carolinensis)
Reptilia CRH 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485597 34
  • 62.05 (n)
zebrafish
(Danio rerio)
Actinopterygii crhb 34 35
  • 62.33 (n)
crha 35
  • 39 (a)
OneToMany
Dr.29164 34
Species where no ortholog for CRH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRH Gene

ENSEMBL:
Gene Tree for CRH (if available)
TreeFam:
Gene Tree for CRH (if available)

Paralogs for CRH Gene

No data available for Paralogs for CRH Gene

Variants for CRH Gene

Sequence variations from dbSNP and Humsavar for CRH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs748404250 Pathogenic 66,177,389(+) GGACC(C/G)GCCCG reference, missense
rs1000540886 -- 66,175,965(+) TTCTC(A/G)TAGAA downstream-variant-500B
rs1000597555 -- 66,175,895(+) TAGTC(A/T)TTGGA downstream-variant-500B
rs1000650130 -- 66,176,170(+) ATTAT(G/T)AACTC downstream-variant-500B
rs1000726446 -- 66,187,924(+) TCAAA(C/G)ATGTT upstream-variant-2KB

Variation tolerance for CRH Gene

Gene Damage Index Score: 0.75; 15.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRH Gene

Human Gene Mutation Database (HGMD)
CRH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CRH Gene

Disorders for CRH Gene

MalaCards: The human disease database

(62) MalaCards diseases for CRH Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CRH in MalaCards View complete list of genes associated with diseases

Genatlas disease for CRH Gene

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Relevant External Links for CRH

Genetic Association Database (GAD)
CRH
Human Genome Epidemiology (HuGE) Navigator
CRH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRH
genes like me logo Genes that share disorders with CRH: view

No data available for UniProtKB/Swiss-Prot for CRH Gene

Publications for CRH Gene

  1. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. (PMID: 18384079) Keck M.E. … Binder E.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 22 46 64
  2. A second corticotropin-releasing hormone gene (CRH2) is conserved across vertebrate classes and expressed in the hindbrain of a basal neopterygian fish, the spotted gar (Lepisosteus oculatus). (PMID: 25521515) Grone B.P. … Maruska K.P. (J. Comp. Neurol. 2015) 2 3 64
  3. Functional characterization of a CRH missense mutation identified in an ADNFLE family. (PMID: 23593457) Sansoni V. … Combi R. (PLoS ONE 2013) 3 4 64
  4. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 46 64
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64

Products for CRH Gene

  • Addgene plasmids for CRH

Sources for CRH Gene

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