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CRH Gene

protein-coding GIFtS: 65

GC08M067251

corticotropin releasing hormone
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRF ^¹, ², ³

Descriptions
Corticotropin-releasing factor ^², ³
Corticotropin-releasing hormone ^³
corticotropin releasing hormone ^²

External Ids
HGNC: 2355¹
Entrez Gene: 1392²
UniProtKB: P06850³
Ensembl: ENSG00000147571⁷

Search outside databases for aliases for CRH gene

Previous GC identifers: GC08M066208 GC08M067028 GC08M066811 GC08M067138

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CRH:

Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid

preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in

response to stress. Marked reduction in CRH has been observed in association with Alzheimer

disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially

fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in

the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is

highly expressed in the placenta. In the placenta CRH is a marker that determines the length of

gestation and the timing of parturition and delivery. A rapid increase in circulating levels of

CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions,

CRH may act as a trigger for parturition. [provided by RefSeq]

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850

Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary

gland

Gene Wiki entry for CRH (Corticotropin-releasing_hormone)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CRH gene

Entrez Gene cytogenetic band: 8q13 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13

CRH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M067251: (about GC identifiers)

Start:	67,251,173 bp from pter
End:	67,253,400 bp from pter
Size:	2,228 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CRF_HUMAN, P06850 (See protein sequence)

Recommended Name: Corticoliberin precursor

Size: 196 amino acids; 21422 Da

Subcellular location: Secreted

PDB structure from and Proteopedia :

3EHT (3D)

3EHU (3D)

REFSEQ proteins: NP_000747.1

ENSEMBL proteins:

ENSP00000276571

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CRH
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Corticotropin Releasing Factor )
	Human Recombinant Proteins from Abnova (CRH)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	7477348

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Antibodies for CRH:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CRH
	Sigma-Aldrich Antibody Arrays and Antibodies for CRH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Corticotropin Releasing Factor ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CRH)
	Novus Biologicals Antibodies for CRH

Assays for CRH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06850

ProtoNet protein and cluster: P06850

1 Blocks protein family: IPB000187 Corticotropin-releasing factor

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850

Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000756

Applied Biosystems Silencer® siRNAs for CRH

Sigma-Aldrich siRNA and siRNA Panels for CRH

Sigma-Aldrich shRNA Panels and shRNA for CRH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CRH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000756
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000756
untagged cDNA clones in CMV expression vector (see all 2): NM_000756

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000756

UniProtKB/Swiss-Prot: CRF_HUMAN, P06850

Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary

gland

Genatlas biochemistry entry for CRH:

corticotropin releasing hormone

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Crh):

behavior/neurological	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	nervous system	other	respiratory system
skin/coat/nails

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	TAS	7867564

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CRH (Your Favorite Gene powered by Ingenuity)

Corticotropin Releasing Hormone Signaling

GeneDecks CRH for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CRH

5/58 Interacting proteins for CRH (ENSP00000276571³) via UniProtKB, MINT, and/or STRING (see all 58 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRHR1	ENSP00000293493³	STRING (score=.999)
FOS	ENSP00000306245³	STRING (score=.996)
POMC	ENSP00000370171³	STRING (score=.993)
CRHR2	ENSP00000340943³	STRING (score=.986)
IL1B	ENSP00000263341³	STRING (score=.974)

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006704	glucocorticoid biosynthetic process	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	TAS	7867564
GO:0007268	synaptic transmission	TAS	7477348
GO:0007565	female pregnancy	TAS	7585095

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CRH available from Tocris Bioscience

Compound	Action	CAS number
NBI 27914 hydrochloride	Selective non-peptide CRF1 antagonist	[184241-44-9]
Astressin 2B	Selective CRF2 antagonist	[681260-70-8]
Sauvagine	CRF agonist	[74434-59-6]
alpha-helical CRF 9-41	CRF receptor antagonist
Astressin	Potent CRF receptor antagonist	[170809-51-5]

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10/31 Novoseek chemical compound relationships for CRH gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acth	95.36	2008	11380490 (9), 1983217 (8), 9274696 (7), 9841549 (7) (see all 99)
hcrh	92.09	44	1651955 (2), 7675936 (1), 10843178 (1), 17186287 (1) (see all 31)
sauvagine	91.99	129	9326293 (3), 8822168 (3), 9612279 (3), 10777063 (3) (see all 47)
antalarmin	87.40	27	9629233 (2), 10822340 (2), 15916629 (2), 10456290 (1) (see all 16)
nbi27914	63.45	1	17976162 (1)
pivagabine	62.55	4	9450153 (1), 9450157 (1)
dsip	60.27	16	1285360 (2), 1378770 (2), 9574859 (2), 1667974 (1) (see all 8)
dehydroepiandrosterone sulfate	57.91	68	8904474 (5), 17631763 (4), 16014403 (4), 11592567 (3) (see all 21)
dhea	57.65	71	15110921 (6), 10802523 (4), 11443185 (3), 1964538 (2) (see all 23)
mhpg	55.74	26	7535389 (2), 17604913 (2), 7911815 (1), 7524463 (1) (see all 14)

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1 PharmGKB drug compound relationship for CRH gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antidepressants	FA	14735130

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CRH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CRH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000756

Sigma-Aldrich siRNA and siRNA Panels for CRH

Sigma-Aldrich shRNA Panels and shRNA for CRH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000756

REFSEQ mRNAs for CRH gene:

NM_000756.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000756

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000756
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000756
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000756

Additional cDNA sequence:

AK075431.1 BC002599.2 BC011031.1 BT007453.1 CR592854.1 CR603754.1 CR617485.1 CR619891.1

CR625216.1 CR626513.1

4 DOTS entries:

DT.213036 DT.92426756 DT.100682388 DT.97842166

24/118 AceView cDNA sequences (see all 118 ):

CR617485 BX104521 BF196912 BQ026511 CR619891 CR592854 BG572446 AI160513

CR603754 BQ026679 CA774731 CA774978 AK075431 CR626513 F05084 F03116

CR625216 BC002599 NM_000756 BQ023511 CA442822 AW513134 BX345878 BM352711

highest scoring ESTs for CRH:

AK075431 AL548935 BC002599 BC011031 BE312069 BF310436 BG434318 BG434472 BG434652 BG572446

Unigene Cluster for CRH:

Corticotropin releasing hormone

Hs.75294 [show with all ESTs]

Unigene Representative Sequence: AK075431

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000276571

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CRH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CRH

¹ / ² / ³

5 probe-sets matching CRH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40382_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	V00571	0.20	1.00	0.72	1
205630_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000756	0.60	1.00	0.82	1
205629_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002599	0.80	1.00	0.91	1
205630_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205629_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.75294
Expression variation in blood from EXPOLDB for CRH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRH gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRH¹	--	corticotropin releasing hormone	87.07(n) 86.73(a)	486977 NM_001014278.1 NP_001014300.1
chimpanzee (Pan troglodytes)	CRH¹	--	corticotropin releasing hormone	99.66(n) 100(a)	464215 XM_519792.2 XP_519792.2
cow (Bos taurus)	CRH¹	--	corticotropin releasing hormone	83.77(n) 78.38(a)	280755 NM_001013400.1 NP_001013418.1
rat (Rattus norvegicus)	Crh¹	--	corticotropin releasing hormone	83.42(n) 81.82(a)	81648 NM_031019.1 NP_112281.1
mouse (Mus musculus)	Crh^{1, 5}	3 (8.00 cM)⁵	corticotropin releasing hormone^{1, 5}	83.6(n)¹ 82.35(a)¹	12918¹ NM_205769.1¹ NP_991338.1¹ AY128673⁵ BC116921⁵ (see all 7)

About this table Species with no ortholog for CRH

ENSEMBL Gene Tree for CRH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/28 NCBI SNPs in CRH are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3176921^1,2	A,C,F,H,O	67253933(-)	`AGAGAT/CTTATT`	1	--	ng3¹		15	CSA EU CSAM NA EA WA	1985
	rs6472257^1,2	A,C,F,H	67254734(+)	`TGGGTC/TTATAC`	1	--	ng3¹		7	EU EA WA NA	556
	rs6158^1,2	C,F,H	67253107(-)	`CACCCG/AGCTCA`	1	--	ut5¹ ese³		7	MN EU EA WA	2218
	rs12721510^1,2	C,F,H	67253736(-)	`AGACAC/ACTGGT`	1	--	ng3¹		11	EU EA WA	1924
	rs6999780^1,2	C,F,H	67254630(+)	`GAGTTG/ATTTAT`	1	--	ng3¹		7	EU EA WA NA	552
	rs12721509^1,2	F,H	67253965(-)	`GTCATC/AATCTA`	1	--	ng3¹		5	EU EA WA	558
	rs6982394^1,2	F,H	67251031(+)	`AGCCAC/ATGACA`	1	--	ng5¹		4	EU EA WA	420
	rs12721507^1,2	H	67254300(-)	`ACAGAC/TTCAAT`	1	--	ng3¹		5	EU EA WA	484
	rs7459924^1,2	H	67251499(+)	`CACGTG/CAATAC`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs12721511^1,2	H	67252263(-)	`ACATGC/GGGCTG`	1	R/G	mis¹ ese³		5	EU EA WA	514

About this table

HapMap Linkage Disequilibrium images for CRH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 122560 disorders: 201400

10/91 Novoseek disease relationships for CRH gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cushing syndrome	85.74	135	7641409 (5), 7891545 (4), 17039427 (3), 1597149 (3) (see all 65)
hypercortisolism	82.03	48	9696732 (2), 16478558 (2), 9238254 (2), 8097579 (2) (see all 31)
acth deficiency	81.08	6	8882784 (2), 1660365 (1), 1313844 (1), 9152624 (1) (see all 5)
acth syndrome ectopic	77.97	22	8254033 (4), 7958079 (3), 9274696 (1), 11729609 (1) (see all 9)
pituitary-dependent cushings syndrome	75.52	8	8157708 (1), 1848486 (1), 7891545 (1), 2178536 (1) (see all 6)
major depression	71.74	120	16478558 (3), 9893154 (2), 15950391 (2), 17825799 (2) (see all 67)
hypercortisolemia	67.85	6	11086823 (1), 1651955 (1), 18406750 (1), 12679470 (1)
pituitary adenoma	62.63	24	15829152 (2), 7958079 (2), 8254033 (2), 8386895 (1) (see all 15)
mood disorders	61.42	53	15705605 (4), 11337098 (2), 9662725 (2), 12438692 (1) (see all 34)
anxiety disorders	60.92	61	16594259 (3), 8491091 (2), 9854171 (2), 10599479 (2) (see all 33)

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1 PharmGKB disease relationship for CRH gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Depression	FA	14735130

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Genatlas disease: CRH

congenital isolated adrenocorticotropic hormone (ACTH) deficiency (?CRH or ? SGKL defect)

Genetic Association Database: CRH
Human Genome Epidemiology Navigator: CRH (34 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1405 PubMed articles for CRH gene (see all 1405 ):

Corticotropin-releasing hormone promoter polymorphisms in patients with rheumatoid arthritis from northwest Spain. (PubMed id 12734882)^{1, 3, 6} Gonzalez-Gay M.A....Ollier W.E. (2003)
The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. (PubMed id 14573312)^{1, 3, 6} Claes S....Van Broeckhoven C. (2003)
A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction. (PubMed id 11555839)^{1, 3, 6} Rosmond R....Bjorntorp P. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. (PubMed id 12154211)^{3, 6} Donn R.P....Thomson W. (2002)
Corticotropin releasing hormone promoter polymorphisms in giant cell arteritis and polymyalgia rheumatica. (PubMed id 12051390)^{3, 6} Gonzalez-Gay M.A....Ollier W.E. (2002)
Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics. (PubMed id 8386360)^{3, 4} Romier C.... Darbon H. (1993)
Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing. (PubMed id 2783917)^{3, 4} Robinson B.G.... Majzoub J.A. (1989)
Isolation and characterization of a corticotropin-releasing hormone- like peptide from human placenta. (PubMed id 3262120)^{3, 4} Sasaki A.... Krieger D.T. (1988)
Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene. (PubMed id 6605851)^{3, 4} Shibahara S.... Numa S. (1983)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1392	HGNC: 2355	AceView: CRH	Ensembl:ENSG00000147571	euGenes: HUgn1392
ECgene: CRH	H-InvDB: CRH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Corticotropin-releasing_hormone

Licensable Technologies for CRH
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CRH gene:

Salk Institute:

Corticotropin Releasing Factor-Binding Protein (CRF-BP)

(see all 2)

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CRH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CRH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CRH		Antibodies for CRH
	Explore super-pooled esiRNAs		Proteins for CRH
	Lentivirus-delivered shRNAs for CRH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CRH)
	Antibodies (CRH)
	Chimera RNAi (CRH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Corticotropin Releasing Factor )
	Antibodies (Corticotropin Releasing Factor )

Search OriGene for CRH

Tocris compounds for CRH

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CRH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CRH Gene at Home site.
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CRH Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CRH

Summaries
for CRH

Genomic Location
for CRH

Proteins
for CRH

Protein Domains/
Families
for CRH

Gene Function
for CRH

Pathways & Interactions
for CRH

Drugs & Compounds
for CRH

Transcripts
for CRH

Expression
for CRH

Orthologs
for CRH

Paralogs
for CRH

SNPs/Variants
for CRH

Disorders & Mutations
for CRH

Medical News
for CRH

Publications
for CRH

Search for CRH

Genome Databases showing CRH

Other Databases showing CRH

Specialized Databases showing CRH

Licensable Technologies
for CRH

Services
for CRH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CRH Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CRH

Summariesfor CRH

Genomic Locationfor CRH

Proteinsfor CRH

Protein Domains/Familiesfor CRH

Gene Functionfor CRH

Pathways & Interactionsfor CRH

Drugs & Compoundsfor CRH

Transcriptsfor CRH

Expression for CRH

Orthologsfor CRH

Paralogsfor CRH

SNPs/Variantsfor CRH

Disorders & Mutationsfor CRH

Medical Newsfor CRH

Publicationsfor CRH

Search for CRH

Genome Databases showing CRH

Other Databases showing CRH

Specialized Databases showing CRH

Licensable Technologiesfor CRH

Servicesfor CRH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CRH

Summaries
for CRH

Genomic Location
for CRH

Proteins
for CRH

Protein Domains/
Families
for CRH

Gene Function
for CRH

Pathways & Interactions
for CRH

Drugs & Compounds
for CRH

Transcripts
for CRH

Expression
for CRH

Orthologs
for CRH

Paralogs
for CRH

SNPs/Variants
for CRH

Disorders & Mutations
for CRH

Medical News
for CRH

Publications
for CRH

Licensable Technologies
for CRH

Services
for CRH