Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CREM Gene

protein-coding GIFtS: 61
GCID: GC10P035415

cAMP responsive element modulator

Explore 26 diseases affiliated with
CREM via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CAMP Responsive Element Modulator¹ ²		CAMP-Responsive Element Modulator²
HCREM-2¹		CREM 2alpha-B Protein²
ICER² ³		CREM 2beta-A Protein²
CREM-2²		Inducible CAMP Early Repressor ICER²
CAMP Response Element Modulator²		Inducible CAMP Early Repressor³

External Ids:	HGNC: 2352¹	Entrez Gene: 1390²	Ensembl: ENSG00000095794⁷	OMIM: 123812⁵	UniProtKB: Q03060³

Export aliases for CREM gene to outside databases

Previous GC identifers: GC10P035163 GC10P035566 GC10P035419 GC10P035455

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CREM:

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and

cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic

cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene

to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants

encoding several different isoforms have been found for this gene, with some of them functioning as activators and

some as repressors of transcription. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060

Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and

cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and

is involved in spermatid maturation (By similarity)

Gene Wiki entry for CREM (CAMP responsive element modulator)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CREM gene promoter:
ATF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CREM promoter sequence

Search SABiosciences Chromatin IP Primers for CREM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREM

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21 Ensembl cytogenetic band: 10p11.21 HGNC cytogenetic band: 10p12.1-p11.1

CREM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREM gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P035415: view genomic region (about GC identifiers)

Start:	35,415,719 bp from pter	End:	35,501,886 bp from pter
Size:	86,168 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060 (See protein sequence)

Recommended Name: cAMP-responsive element modulator

Size: 361 amino acids; 38940 Da

Subunit: Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34

Subcellular location: Nucleus

Sequence caution: Sequence=AAB03751.1; Type=Erroneous termination; Positions=361; Note=Translated as Tyr;

Sequence=AAF68266.2; Type=Erroneous gene model prediction; Sequence=CAH72496.1; Type=Erroneous gene model prediction;

Sequence=CAH72497.1; Type=Erroneous gene model prediction; Sequence=CAI12138.1; Type=Erroneous gene model prediction;

Sequence=CAI12139.1; Type=Erroneous gene model prediction; Sequence=CAI12143.1; Type=Erroneous gene model prediction;

Secondary accessions: A8K014 A8K3J7 A8K6A1 B4DXC1 O75519 Q14501 Q14503 Q14504 Q14505 Q14506 Q15731

Q16114 Q16116 Q5T9H7 Q5W1A6 Q5W1A8 Q5W1A9 Q5W1B0 Q5W1B2 Q7Z2Q6 Q8IVD4 Q96AG7 Q9NZ98 Q9NZ99 Q9NZB9

Alternative promoter usage, Alternative splicing: 23 isoforms: Q03060-5 Q03060-1 Q03060-6 Q03060-2 Q03060-7 Q03060-8 Q03060-9 Q03060-10

Q03060-11 Q03060-12 Q03060-13 Q03060-14 Q03060-15 Q03060-16 Q03060-17 Q03060-19

Q03060-20 Q03060-21 Q03060-22 Q03060-23 Q03060-24 Q03060-25 Q03060-26 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CREM: NX_Q03060

Post-translational modifications:

Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome¹

Stimulated by phosphorylation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q03060

CREM Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (26 alternative transcripts):

NP_001254491.1 NP_001254492.1 NP_001254493.1 NP_001254494.1 NP_001254495.1 NP_001254496.1 NP_001254497.1 NP_001254498.1

NP_001254499.1 NP_001872.3 NP_853549.1 NP_874386.1 NP_874387.1 NP_874388.1 NP_874389.1 NP_874390.1

NP_874392.1 NP_874393.1 NP_877570.1 NP_877571.1 NP_877572.1 NP_877573.1 NP_898829.1 NP_898830.1

NP_898831.1 NP_898883.1

ENSEMBL proteins:

ENSP00000419018 ENSP00000363858 ENSP00000417058 ENSP00000420453 ENSP00000420437

ENSP00000346804 ENSP00000419924 ENSP00000403938 ENSP00000265372 ENSP00000418798

ENSP00000363866 ENSP00000337138 ENSP00000420511 ENSP00000418761 ENSP00000393538

ENSP00000417068 ENSP00000418249 ENSP00000418019 ENSP00000363853 ENSP00000345384

ENSP00000363854 ENSP00000418450 ENSP00000354593 ENSP00000417165 ENSP00000379225

ENSP00000417399 ENSP00000418336 ENSP00000341875 ENSP00000417130 ENSP00000419684

ENSP00000417807 ENSP00000420681 ENSP00000417460 ENSP00000349387 ENSP00000419075

ENSP00000417562 ENSP00000419810 ENSP00000344365 ENSP00000417327 ENSP00000379232

ENSP00000333055 ENSP00000409220 ENSP00000363860

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 7): CREM OriGene Custom Protein Services for CREM
	GenScript Custom Purified and Recombinant Proteins Services for CREM
	Novus Biologicals CREM Proteins Novus Biologicals CREM Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CREM

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005667	transcription factor complex	IEA	--

CREM for ontologies About GeneDecksing

CREM Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: CREM OriGene Custom Antibody Services for CREM
	GenScript Custom Superior Antibodies Services for CREM
	Novus Biologicals CREM Antibodies
	Search for Antibodies for CREM at Abcam
	Uscn Antibodies for CREM
	ThermoFisher Antibodies for CREM

Assay Products for CREM:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CREM
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CREM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CREM for domains About GeneDecksing

3 InterPro domains/families:

IPR004827 bZIP

IPR003102 Coactivator_CBP_pKID

IPR001630 Leuzip_CREB

Graphical View of Domain Structure for InterPro Entry Q03060

ProtoNet protein and cluster: Q03060

3 Blocks protein families:

IPB001630 cAMP response element binding (CREB) protein signature

IPB003102 Coactivator CBP

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060

Similarity: Belongs to the bZIP family

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

Similarity: Contains 1 KID (kinase-inducible) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060

Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and

cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and

is involved in spermatid maturation (By similarity)

Genatlas biochemistry entry for CREM:

cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin

spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor) acting as

repressor,regulated in a circadian manner in the pineal gland

miRNA Products:		OriGene 3'-UTR Clone (see all 11): CREM Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREM
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CREM (see all 18):
		hsa-miR-1197 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-3942-5p hsa-miR-202 hsa-miR-624 hsa-miR-548x hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: CREM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREM (see all 7) OriGene shRNA RFP: CREM OriGene siRNA: CREM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREM

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CREM

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREM (see all 31) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREM (see all 22) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 21): CREM (NM_181571)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREM

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CREM
		Search LifeMap BioReagents cell lines for CREM

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREM

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	7916662
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	10373550
GO:0008140	cAMP response element binding protein binding	NAS	8206879
GO:0043565	sequence-specific DNA binding	IEA	--

CREM for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CREM: Crem^tm1Saco Crem^tm1.1Endo
     10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Crem):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	liver/biliary system
mortality/aging	muscle	nervous system	reproductive system	respiratory system

CREM for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of cAMP-Dependent PKA

	Activation of cAMP-Dependent PKA	1.00			Activation of PKA through GPCR	0.71
	cAMP Pathway	0.77			PKA Signaling	0.56

Transcription_CREM signaling in testis

Transcription_CREM signaling in testis

1.00

Transcription CREM signaling in testis

0.96

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

Selenium Metabolism and Selenoproteins

Selenium Metabolism and Selenoproteins

1.00

DREAM Repression and Dynorphin Expression

DREAM Repression and Dynorphin Expression

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CREM

Transcription CREM signaling in testis

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CREM (see all 6)

	Activation of PKA through GPCR
	PKA Signaling
	cAMP Pathway
	DREAM Repression and Dynorphin Expression
	Activation of cAMP-Dependent PKA

1 GeneGo (Thomson Reuters) Pathway for CREM

Transcription CREM signaling in testis

2 BioSystems Pathways for CREM

	SIDS Susceptibility Pathways
	Selenium Metabolism and Selenoproteins

CREM for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CREM

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/60 Interacting proteins for CREM (Q03060³ ENSP00000265372⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 60)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF1	P18846³, ENSP00000262053⁴	I2D: score=5 STRING: ENSP00000262053
SPI1	P17947³, ENSP00000227163⁴	I2D: score=3 STRING: ENSP00000227163
TAF4	O00268³, ENSP00000252996⁴	I2D: score=3 STRING: ENSP00000252996
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=2 STRING: ENSP00000262367
CSNK1A1	P48729³, ENSP00000261798⁴	I2D: score=2 STRING: ENSP00000261798

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006006	glucose metabolic process	--	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	7916662
GO:0006631	fatty acid metabolic process	--	--
GO:0006687	glycosphingolipid metabolic process	IEA	--

CREM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CREM for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CREM

1 HMDB Compound for CREM About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

8 Novoseek chemical compound relationships for CREM gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	63	25	7916662 (2), 10871653 (2), 9517483 (2), 11344215 (2) (see all 11)
leucine	49.3	3	14713288 (1), 10525188 (1)
melatonin	44.9	6	10752062 (2), 9618898 (2)
forskolin	41.2	6	17712720 (1), 9544985 (1), 10660591 (1), 9545284 (1) (see all 5)
adenylate	18.7	1	10697414 (1)
serine	15.8	1	8414969 (1)
tyrosine	0	1	10812201 (1)
glutamate	0	2	9517483 (2)

Search CenterWatch for drugs/clinical trials and news about CREM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CREM gene (30 alternative transcripts):

NM_001267562.1 NM_001267563.1 NM_001267564.1 NM_001267565.1 NM_001267566.1 NM_001267567.1 NM_001267568.1 NM_001267569.1

NM_001267570.1 NM_001881.3 NM_181571.2 NM_182717.1 NM_182718.1 NM_182719.1 NM_182720.1 NM_182721.1

NM_182723.1 NM_182724.1 NM_182769.2 NM_182770.2 NM_182771.1 NM_182772.1 NM_183011.1 NM_183012.1

NM_183013.2 NM_183060.2 NM_182722.1 NM_182725.1 NM_182850.2 NM_182853.2

Unigene Clusters for CREM:

CAMP responsive element modulator

Hs.200250 [show with all ESTs], Hs.686182 [show with all ESTs]

Unigene Representative Sequences: AB209533, CB990518

18/55 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 55):

ENST00000474362 ENST00000496626 ENST00000482646 ENST00000489388 ENST00000374726(uc001ixx.3)

ENST00000461968 ENST00000490460 ENST00000466251 ENST00000482633 ENST00000495960

ENST00000469949 ENST00000460270 ENST00000496019 ENST00000354759 ENST00000489321

ENST00000427847 ENST00000345491(uc001iyb.3 uc001iyc.3) ENST00000487132

miRNA Products:		OriGene 3'-UTR Clone (see all 11): CREM Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREM
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CREM (see all 18):
		hsa-miR-1197 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-3942-5p hsa-miR-202 hsa-miR-624 hsa-miR-548x hsa-miR-3662

		SwitchGear 3'UTR luciferase reporter plasmid: CREM 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREM (see all 7) OriGene shRNA RFP: CREM OriGene siRNA: CREM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREM

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREM (see all 31) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREM (see all 22) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 21): CREM (NM_181571)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREM
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREM

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CREM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREM

Additional cDNA sequence: Y08959.1

24/42 DOTS entries (see all 42):

DT.107647 DT.92437248 DT.100726650 DT.99984774 DT.92437260 DT.92437247 DT.86821221 DT.100687398

DT.101981359 DT.100689650 DT.427387 DT.101980105 DT.101980377 DT.101981362 DT.101981360 DT.101983744

DT.86821220 DT.121286410 DT.454725 DT.91888806 DT.92437262 DT.100763703 DT.101983746 DT.121286444

24/280 AceView cDNA sequences (see all 280):

NM_182720 NM_182718 NM_182772 NM_182853 BX356674 AW237448 NM_183060 BI964028

AI366788 BI966160 BC066342 NM_182717 AA972804 NM_181571 AI582337 NM_001881

BG170910 BQ052261 CD358842 AI090975 BX101868 NM_182769 BC017117 NM_182721

GeneLoc Exon Structure

5/25 Alternative Splicing Database (ASD) splice patterns (SP) for CREM (see all 25) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	·	1i	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·
SP1:																			-						-		-		-		-		-		-		-		-						-		-		-		-
SP2:																																													-		-		-		-
SP3:																			-		-				-		-		-		-		-		-		-		-						-		-		-		-
SP4:																			-		-		-		-		-		-		-		-		-		-		-						-		-		-		-
SP5:																			-		-				-		-		-		-		-		-		-		-

ExUns:	10f	^	11	^	12	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18a	·	18b	·	18c	·	18d	·	18e	^	19a	·	19b	·	19c	·	19d	·	19e	·	19f
SP1:	-		-		-		-		-		-		-
SP2:	-				-		-		-		-		-		-				-		-		-		-		-		-
SP3:	-
SP4:	-		-		-		-		-		-		-		-				-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for CREM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CREM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAGTTGCT

About this image

CREM expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Spermatid

Germ Cells, Male Gametocytes

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CREM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREM

SOURCE GeneReport for Unigene clusters: Hs.200250 Hs.686182

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060

Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form

in testes

SABiosciences Expression via Pathway-Focused PCR Arrays including CREM:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Synaptic Plasticity in human mouse rat

Cardiotoxicity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CREM
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREM
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREM

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CREM gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crem^{1 , 5}	cAMP responsive element modulator^{1, 5}	91.55(n)¹ 92.23(a)¹		18 (2.14 cM)⁵ 12916¹ NM_001110859.1¹ NP_001104329.1¹ 3266048⁵
chicken (Gallus gallus)	Aves	Q7T3L4_CHICK⁶	ICER protein	69(a)	1 ↔ 1	2(12910463-12929597)
lizard (Anolis carolinensis)	Reptilia	CREM⁶	--	63(a)	1 ↔ 1	6(10823012-10846946)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-177e13.4¹	si:dkey-177e13.4	61.11(n) 58.16(a)		555432 XM_677932.5 XP_683024.3
fruit fly (Drosophila melanogaster)	Insecta	CrebB-17A⁶	Cyclic-AMP response element binding protein B at 1...	18(a)	possible ortholog	X(18260733-18271897)
worm (Caenorhabditis elegans)	Secernentea	crh-1¹	Protein CRH-1	47.5(n) 39.06(a)		176597 NM_001027689.1 NP_001022860.1

ENSEMBL Gene Tree for CREM (if available)
TreeFam Gene Tree for CREM (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CREM gene

ATF1² CREB1²

5 SIMAP similar genes for CREM using alignment to 26 protein entries: CREM_HUMAN (see all proteins):

CREB1 EWSR1/ATF1 fusion ATF1 CREB3L4 CREB3L1

CREM for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111994488^1,2		--	35133247(+)	`AGATGG/CAGCCT`	9	--	us2k¹		1		CSA	2
rs11592989^1,2	C,F,H,	--	35133494(+)	`acaggC/Agtgag`	9	--	us2k¹		3		NA	124
rs76947303^1,2		--	35133727(+)	`CTCAAG/ACTTCT`	9	--	us2k¹		1		EA	120
rs59891080^1,2		--	35133766(+)	`TGGCTA/GTGAAT`	9	--	us2k¹		0	--	--	--	--
rs16935881^1,2	F,	--	35134018(+)	`ACCTGA/CCRACA`	9	--	us2k¹		3		WA NA EA	358
rs73260847^1,2	C,F,	--	35134315(+)	`CTCGGG/TGCCTC`	9	--	ut5¹ nc-transcript-variantus2k¹		1		WA	118
rs12764135^1,2	C	--	35134724(+)	`cgggcC/Tgggac`	9	--	int¹ us2k¹		1		NA	2
rs12764861^1,2	C	--	35134939(+)	`ACTCGC/GAAAAG`	9	--	int¹ ut5¹ trp³		0	--	--	--	--
rs12764516^1,2	C	--	35134952(+)	`AAAGGA/TATCCA`	9	--	int¹ ut5¹ ese³ trp³		0	--	--	--	--
rs7902166^1,2	C,F,H,	--	35135667(+)	`ACTTAC/AAGGGC`	9	--	int¹		5		NS EA WA	534

HapMap Linkage Disequilibrium report for CREM (35415719 - 35501886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CREM
1 CNV: 58444

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREM

DNA2.0 Custom Variant and Variant Library Synthesis for CREM

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CREM for disorders           About GeneDecksing

OMIM gene information: 123812    OMIM disorders: --

20/26 diseases for CREM (see all 26):    About MalaCards

growth hormone secreting pituitary adenoma human t-cell leukemia virus type 1 lupus erythematosus pituitary adenoma

systemic lupus erythematosus male infertility panic disorder infertility

neuroepithelioma adrenocortical tumor t-cell leukemia adenoma

thymoma azoospermia adhd myeloid leukemia

hepatitis b leukemia alzheimer's disease nasopharyngitis

1 disease from the University of Copenhagen DISEASES database for CREM:

Male infertility

4 Novoseek disease relationships for CREM gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
infertility	41.9	3	15705296 (1), 8600391 (1), 14965334 (1)
infertility male	22.2	2	9510006 (1)
lupus erythematosus systemic	5.36	2	15841182 (2)
tumors	0	2	9545284 (2)

Genetic Association Database (GAD): CREM
Human Genome Epidemiology (HuGE) Navigator: CREM (11 documents)

Export disorders for CREM gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CREM gene, integrated from 9 sources (see all 192):
(articles sorted by number of sources associating them with CREM)

Utopia: connect your pdf to the dynamic
world of online information

Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PubMed id 7916662)^{1, 2, 3, 9} Masquilier D.... Sassone-Corsi P. (1993)
Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. (PubMed id 1461747)^{1, 2, 3} Meyer T.E. and Habener J.F. (1992)
Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. (PubMed id 12397208)^{1, 2, 9} Gellersen B.... Behr R. (2002)
Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PubMed id 10373550)^{1, 2, 9} Pati D.... Plon S.E. (1999)
Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. (PubMed id 8206879)^{1, 2, 9} Fujimoto T.... Yoshida M. (1994)
Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility? (PubMed id 16143638)^{1, 2} Vouk K.... Rozman D. (2005)
Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis. (PubMed id 14511788)^{1, 2} Bloecher S.... Steger K. (2003)
Human nuclear transcription factor gene CREM: genomic organization, mutation screening, and association analysis in panic disorder. (PubMed id 12555239)^{1, 4} Domschke K....Deckert J. (2003)
CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis. (PubMed id 11044457)^{1, 2} Behr R. and Weinbauer G.F. (2000)
cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. (PubMed id 8622971)^{1, 2} Bodor J.... Habener J.F. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1390	HGNC: 2352	AceView: CREM	Ensembl:ENSG00000095794	euGenes: HUgn1390
ECgene: CREM	H-InvDB: CREM

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CREM	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CREM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CREM gene:
Search GeneIP for patents involving CREM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CREM		OriGene shRNA RFP for CREM
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREM		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREM
	OriGene Protein Over-expression Lysate for CREM		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CREM		OriGene 3'-UTR Clone for CREM
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREM		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREM
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CREM		OriGene Custom Protein Services for CREM
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREM
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREM
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREM
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREM
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREM
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREM

	GenScript Custom Purified and Recombinant Proteins Services for CREM		GenScript cDNA clones with any tag delivered in your preferred vector for CREM
	GenScript Custom Assay Services for CREM		GenScript Custom Superior Antibodies Services for CREM
	GenScript Custom overexpressing Cell Line Services for CREM		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CREM promoter
	Search Chromatin IP Primers for CREM
	RT² qPCR Primer Assay in human, mouse / rat CREM
	GNC Network for CREM
	SABiosciences PCR Arrays including human, mouse / rat CREM

Search Tocris compounds for CREM

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CREM antibodies
	CREM proteins
	CREM lysates

	Search for Antibodies for CREM at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CREM
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CREM Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CREM

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREM

	SwitchGear 3'UTR luciferase reporter plasmids for CREM
	SwitchGear Promoter luciferase reporter plasmids for CREM

ThermoFisher Antibodies for CREM

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREM

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CREM gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CREM Gene

cAMP responsive element modulator

Aliases
for CREM gene

Summaries
for CREM gene

Genomic Views
for CREM gene

Proteins
for CREM gene

Protein Domains /
Families
for CREM gene

Function
for CREM gene

Pathways & Interactions
for CREM gene

Drugs & Compounds
for CREM gene

Transcripts
for CREM gene

Expression
for CREM gene

Orthologs
for CREM gene

Paralogs
for CREM gene

Genomic Variants
for CREM gene

Disorders / Diseases
for CREM gene

Publications
for CREM gene

External Searches for CREM gene

Genome Databases showing CREM gene

Other Databases showing CREM gene

Specialized Databases showing CREM gene

Intellectual Property
for CREM gene

Products
for CREM gene

View Random Gene

Advanced Search

Export list of displayed genes

CREM Gene

cAMP responsive element modulator

Aliasesfor CREM gene

Summariesfor CREM gene

Genomic Viewsfor CREM gene

Proteinsfor CREM gene

Protein Domains /Familiesfor CREM gene

Functionfor CREM gene

Pathways & Interactionsfor CREM gene

Drugs & Compoundsfor CREM gene

Transcriptsfor CREM gene

Expression for CREM gene

Orthologsfor CREM gene

Paralogsfor CREM gene

Genomic Variantsfor CREM gene

Disorders / Diseasesfor CREM gene

Publicationsfor CREM gene

External Searches for CREM gene

Genome Databases showing CREM gene

Other Databases showing CREM gene

Specialized Databases showing CREM gene

Intellectual Propertyfor CREM gene

Productsfor CREM gene

View Random Gene

Aliases
for CREM gene

Summaries
for CREM gene

Genomic Views
for CREM gene

Proteins
for CREM gene

Protein Domains /
Families
for CREM gene

Function
for CREM gene

Pathways & Interactions
for CREM gene

Drugs & Compounds
for CREM gene

Transcripts
for CREM gene

Expression
for CREM gene

Orthologs
for CREM gene

Paralogs
for CREM gene

Genomic Variants
for CREM gene

Disorders / Diseases
for CREM gene

Publications
for CREM gene

Intellectual Property
for CREM gene

Products
for CREM gene