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Aliases for CREM Gene

Aliases for CREM Gene

  • CAMP Responsive Element Modulator 2 3 5
  • ICER 3 4
  • Inducible CAMP Early Repressor ICER 3
  • CAMP-Responsive Element Modulator 3
  • CAMP Response Element Modulator 3
  • Inducible CAMP Early Repressor 4
  • CREM 2alpha-B Protein 3
  • CREM 2beta-A Protein 3
  • HCREM-2 3
  • CREM-2 3

External Ids for CREM Gene

Previous GeneCards Identifiers for CREM Gene

  • GC10P035163
  • GC10P035566
  • GC10P035419
  • GC10P035455
  • GC10P035415

Summaries for CREM Gene

Entrez Gene Summary for CREM Gene

  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREM Gene

CREM (CAMP Responsive Element Modulator) is a Protein Coding gene. Diseases associated with CREM include Female Stress Incontinence and Type 1 Diabetes Mellitus 10. Among its related pathways are Circadian rythm related genes and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is CREB1.

UniProtKB/Swiss-Prot for CREM Gene

  • Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).

  • Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Wiki entry for CREM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREM Gene

Genomics for CREM Gene

Regulatory Elements for CREM Gene

Enhancers for CREM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G035191 1.6 Ensembl ENCODE dbSUPER 19.4 +67.6 67568 6.1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF766 ENSG00000271335 CREM CUL2 RNU7-77P ENSG00000230534 GC10M035186 ENSG00000269952
GH10G035214 1.4 Ensembl ENCODE dbSUPER 18.7 +90.0 89981 4.9 RB1 ZNF133 KLF17 FEZF1 ZNF2 RAD21 YY1 ZNF121 EGR1 SCRT2 CREM RNU7-77P ENSG00000230534 CUL2 ENSG00000269952 RNU6-794P
GH10G035208 1.3 FANTOM5 ENCODE dbSUPER 19.6 +82.5 82533 2.3 TBP PKNOX1 RAD21 GABPA JUND ATF3 NFYB SCRT2 HNF4G ZNF143 CREM RNU7-77P ENSG00000230534 CUL2 CCNY ENSG00000269952 GC10M035186
GH10G035130 1.5 FANTOM5 ENCODE dbSUPER 15.7 +5.5 5456 3.5 HDGF ELF3 TBP PKNOX1 FOXA2 TBL1XR1 WRNIP1 INSM2 FEZF1 ZNF2 CREM CUL2 CCNY RNU7-77P ENSG00000230534
GH10G035148 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +23.1 23092 2.2 TBP PKNOX1 CBX3 TBL1XR1 ZSCAN4 SIN3A BMI1 RFX5 EGR1 CBX5 CREM CUL2 ATP6V1G1P4 RNU7-77P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CREM on UCSC Golden Path with GeneCards custom track

Promoters for CREM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000026897 709 2201 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Transcription factor binding sites by QIAGEN in the CREM gene promoter:

Genomic Location for CREM Gene

Chromosome:
10
Start:
35,126,791 bp from pter
End:
35,212,958 bp from pter
Size:
86,168 bases
Orientation:
Plus strand

Genomic View for CREM Gene

Genes around CREM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREM Gene

Proteins for CREM Gene

neXtProt entry for CREM Gene

Post-translational modifications for CREM Gene

Other Protein References for CREM Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CREM

No data available for DME Specific Peptides for CREM Gene

Domains & Families for CREM Gene

Gene Families for CREM Gene

Graphical View of Domain Structure for InterPro Entry

Q03060

UniProtKB/Swiss-Prot:

CREM_HUMAN :
  • Belongs to the bZIP family.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREM: view

Function for CREM Gene

Molecular function for CREM Gene

GENATLAS Biochemistry:
cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor) acting as repressor,regulated in a circadian manner in the pineal gland
UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
UniProtKB/Swiss-Prot Function:
Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Ontology (GO) - Molecular Function for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 16899810
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003677 DNA binding NAS 7916662
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 21976679
genes like me logo Genes that share ontologies with CREM: view
genes like me logo Genes that share phenotypes with CREM: view

Animal Models for CREM Gene

MGI Knock Outs for CREM:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREM Gene

Localization for CREM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREM Gene

Nucleus.
Isoform 6: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREM gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,TAS 8206879
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CREM: view

Pathways & Interactions for CREM Gene

genes like me logo Genes that share pathways with CREM: view

Gene Ontology (GO) - Biological Process for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 12626549
GO:0006006 glucose metabolic process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7916662
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with CREM: view

No data available for SIGNOR curated interactions for CREM Gene

Drugs & Compounds for CREM Gene

(6) Drugs for CREM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(2) Additional Compounds for CREM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREM: view

Transcripts for CREM Gene

mRNA/cDNA for CREM Gene

(66) REFSEQ mRNAs :
(23) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(48) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CREM Gene

CAMP responsive element modulator:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREM Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

ExUns: 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c · 19d · 19e · 19f
SP1: - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - -
SP17: - - - - -
SP18: - - - - - - - - - - -
SP19: - - - -
SP20: - - -
SP21: - - - - - - - -
SP22: - -
SP23: -
SP24: - - - - - -
SP25:

Relevant External Links for CREM Gene

GeneLoc Exon Structure for
CREM
ECgene alternative splicing isoforms for
CREM

Expression for CREM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CREM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREM Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for CREM Gene

This gene is overexpressed in Testis (54.2) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CREM Gene



Protein tissue co-expression partners for CREM Gene

NURSA nuclear receptor signaling pathways regulating expression of CREM Gene:

CREM

SOURCE GeneReport for Unigene cluster for CREM Gene:

Hs.200250

mRNA Expression by UniProt/SwissProt for CREM Gene:

Q03060-CREM_HUMAN
Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.

Evidence on tissue expression from TISSUES for CREM Gene

  • Nervous system(4.7)
  • Adrenal gland(4.6)
  • Heart(4.4)
  • Blood(2.9)
  • Liver(2.2)
  • Intestine(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CREM: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CREM Gene

Orthologs for CREM Gene

This gene was present in the common ancestor of animals.

Orthologs for CREM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREM 34 35
  • 94.98 (n)
dog
(Canis familiaris)
Mammalia CREM 34 35
  • 94.94 (n)
rat
(Rattus norvegicus)
Mammalia Crem 34
  • 92.57 (n)
mouse
(Mus musculus)
Mammalia Crem 34 16 35
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia CREM 34 35
  • 88.74 (n)
oppossum
(Monodelphis domestica)
Mammalia CREM 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREM 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CREM 34 35
  • 73.81 (n)
lizard
(Anolis carolinensis)
Reptilia CREM 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crema 34 35
  • 67.26 (n)
cremb 35
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 35
  • 42 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3621 34
Species where no ortholog for CREM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CREM Gene

ENSEMBL:
Gene Tree for CREM (if available)
TreeFam:
Gene Tree for CREM (if available)

Paralogs for CREM Gene

Variants for CREM Gene

Sequence variations from dbSNP and Humsavar for CREM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000022950 -- 35,132,082(+) TGTAA(C/T)CCCAG intron-variant
rs1000069706 -- 35,126,713(+) TTGCC(C/T)CCGCC intron-variant, upstream-variant-2KB
rs1000074583 -- 35,181,201(+) TTGTG(A/C)CATTT intron-variant
rs1000092954 -- 35,201,862(+) GTAAG(C/T)TTATA intron-variant
rs1000121464 -- 35,134,145(+) GAGTT(A/C)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREM Gene

Variant ID Type Subtype PubMed ID
dgv706n100 CNV gain 25217958
dgv707n100 CNV gain 25217958
dgv96e201 CNV deletion 23290073
esv2659986 CNV deletion 23128226
esv2668859 CNV deletion 23128226
esv2735328 CNV deletion 23290073
esv2735362 CNV deletion 23290073
esv3546152 CNV deletion 23714750
esv3576372 CNV gain 25503493
esv3622893 CNV loss 21293372
esv3622894 CNV loss 21293372
nsv1039051 CNV gain 25217958
nsv475915 CNV novel sequence insertion 20440878
nsv550398 CNV gain 21841781
nsv820199 CNV loss 19587683

Variation tolerance for CREM Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREM Gene

Disorders for CREM Gene

MalaCards: The human disease database

(2) MalaCards diseases for CREM Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
female stress incontinence
  • female urinary stress incontinence
type 1 diabetes mellitus 10
  • iddm10
- elite association - COSMIC cancer census association via MalaCards
Search CREM in MalaCards View complete list of genes associated with diseases

Relevant External Links for CREM

Genetic Association Database (GAD)
CREM
Human Genome Epidemiology (HuGE) Navigator
CREM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREM
genes like me logo Genes that share disorders with CREM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREM Gene

Publications for CREM Gene

  1. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PMID: 7916662) Masquilier D. … Sassone-Corsi P. (Cell Growth Differ. 1993) 2 3 4 22 64
  2. Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. (PMID: 12397208) Gellersen B. … Behr R. (Mol. Hum. Reprod. 2002) 3 4 22 64
  3. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PMID: 10373550) Pati D. … Plon S.E. (Mol. Cell. Biol. 1999) 3 4 22 64
  4. Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. (PMID: 8206879) Fujimoto T. … Yoshida M. (J. Biochem. 1994) 3 4 22 64
  5. Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. (PMID: 1461747) Meyer T.E. … Habener J.F. (Nucleic Acids Res. 1992) 2 3 4 64

Products for CREM Gene

Sources for CREM Gene

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