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Aliases for CREM Gene

Aliases for CREM Gene

  • CAMP Responsive Element Modulator 2 3 5
  • ICER 3 4
  • Inducible CAMP Early Repressor ICER 3
  • CAMP Response Element Modulator 3
  • Inducible CAMP Early Repressor 4
  • CREM 2alpha-B Protein 3
  • CREM 2beta-A Protein 3
  • HCREM-2 3
  • CREM-2 3

External Ids for CREM Gene

Previous GeneCards Identifiers for CREM Gene

  • GC10P035163
  • GC10P035566
  • GC10P035419
  • GC10P035455
  • GC10P035415

Summaries for CREM Gene

Entrez Gene Summary for CREM Gene

  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREM Gene

CREM (CAMP Responsive Element Modulator) is a Protein Coding gene. Among its related pathways are cGMP-PKG signaling pathway and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot for CREM Gene

  • Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).

  • Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Wiki entry for CREM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREM Gene

Genomics for CREM Gene

Regulatory Elements for CREM Gene

Enhancers for CREM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CREM on UCSC Golden Path with GeneCards custom track

Promoters for CREM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CREM on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CREM gene promoter:

Genomic Location for CREM Gene

Chromosome:
10
Start:
35,126,791 bp from pter
End:
35,212,958 bp from pter
Size:
86,168 bases
Orientation:
Plus strand

Genomic View for CREM Gene

Genes around CREM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREM Gene

Proteins for CREM Gene

neXtProt entry for CREM Gene

Proteomics data for CREM Gene at MOPED

Post-translational modifications for CREM Gene

No data available for DME Specific Peptides for CREM Gene

Domains & Families for CREM Gene

Gene Families for CREM Gene

Graphical View of Domain Structure for InterPro Entry

Q03060

UniProtKB/Swiss-Prot:

CREM_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Contains 1 KID (kinase-inducible) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREM: view

Function for CREM Gene

Molecular function for CREM Gene

GENATLAS Biochemistry:
cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor) acting as repressor,regulated in a circadian manner in the pineal gland
UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
UniProtKB/Swiss-Prot Function:
Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Ontology (GO) - Molecular Function for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 10373550
genes like me logo Genes that share ontologies with CREM: view
genes like me logo Genes that share phenotypes with CREM: view

Animal Models for CREM Gene

MGI Knock Outs for CREM:

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CREM Gene

Localization for CREM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREM Gene

Nucleus.
Isoform 6: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREM Gene COMPARTMENTS Subcellular localization image for CREM gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for CREM Gene

Pathways & Interactions for CREM Gene

genes like me logo Genes that share pathways with CREM: view

Gene Ontology (GO) - Biological Process for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7916662
GO:0007165 signal transduction TAS 7916662
GO:0007275 multicellular organism development IEA --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with CREM: view

No data available for SIGNOR curated interactions for CREM Gene

Drugs & Compounds for CREM Gene

(6) Drugs for CREM Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(2) Additional Compounds for CREM Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREM: view

Transcripts for CREM Gene

Unigene Clusters for CREM Gene

CAMP responsive element modulator:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREM Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

ExUns: 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c · 19d · 19e · 19f
SP1: - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - -
SP17: - - - - -
SP18: - - - - - - - - - - -
SP19: - - - -
SP20: - - -
SP21: - - - - - - - -
SP22: - -
SP23: -
SP24: - - - - - -
SP25:

Relevant External Links for CREM Gene

GeneLoc Exon Structure for
CREM
ECgene alternative splicing isoforms for
CREM

Expression for CREM Gene

mRNA expression in normal human tissues for CREM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREM Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for CREM Gene

This gene is overexpressed in Testis (54.2) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREM Gene



SOURCE GeneReport for Unigene cluster for CREM Gene Hs.200250

mRNA Expression by UniProt/SwissProt for CREM Gene

Q03060-CREM_HUMAN
Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
genes like me logo Genes that share expression patterns with CREM: view

Protein tissue co-expression partners for CREM Gene

In Situ Assay Products

Orthologs for CREM Gene

This gene was present in the common ancestor of animals.

Orthologs for CREM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CREM 35
  • 88.74 (n)
  • 89.3 (a)
CREM 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREM 35
  • 94.94 (n)
  • 93.64 (a)
CREM 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crem 35
  • 92.34 (n)
  • 91.89 (a)
Crem 16
Crem 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CREM 35
  • 94.98 (n)
  • 95.32 (a)
CREM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crem 35
  • 92.57 (n)
  • 91.89 (a)
oppossum
(Monodelphis domestica)
Mammalia CREM 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREM 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CREM 35
  • 73.81 (n)
  • 70.07 (a)
CREM 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREM 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crema 35
  • 67.26 (n)
  • 72.12 (a)
crema 36
  • 55 (a)
ManyToMany
cremb 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3621 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 36
  • 42 (a)
OneToMany
Species with no ortholog for CREM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CREM Gene

ENSEMBL:
Gene Tree for CREM (if available)
TreeFam:
Gene Tree for CREM (if available)

Paralogs for CREM Gene

Paralogs for CREM Gene

genes like me logo Genes that share paralogs with CREM: view

Variants for CREM Gene

Sequence variations from dbSNP and Humsavar for CREM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1804604 - 35,206,922(+) TTACC(A/G)GATCC nc-transcript-variant, reference, missense
rs1478463 -- 35,184,107(-) TTATA(C/T)ACTTC intron-variant
rs1531550 -- 35,175,850(-) AACCT(A/G/T)CCAAA intron-variant
rs1545756 -- 35,190,507(+) ATGTT(C/T)GTTAT intron-variant
rs1545757 -- 35,156,660(+) GCTTC(A/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREM Gene

Variant ID Type Subtype PubMed ID
nsv895019 CNV Gain 21882294
nsv895020 CNV Gain 21882294
esv2735328 CNV Deletion 23290073
dgv108e201 CNV Deletion 23290073
esv2735362 CNV Deletion 23290073
nsv820199 CNV Loss 19587683
esv2668859 CNV Deletion 23128226
esv2659986 CNV Deletion 23128226

Variation tolerance for CREM Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREM Gene

HapMap Linkage Disequilibrium report
CREM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREM Gene

Disorders for CREM Gene

Relevant External Links for CREM

Genetic Association Database (GAD)
CREM
Human Genome Epidemiology (HuGE) Navigator
CREM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREM

No disorders were found for CREM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREM Gene

Publications for CREM Gene

  1. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PMID: 7916662) Masquilier D. … Sassone-Corsi P. (Cell Growth Differ. 1993) 2 3 4 23 67
  2. Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells. (PMID: 18700132) Sasamori E. … Kikuchi H. (Arch. Biochem. Biophys. 2008) 3 23
  3. Regulation of human MC2-R gene expression by CREB, CREM, and ICER in the adrenocortical cell line Y1. (PMID: 17712720) Zwermann O. … Reincke M. (Horm. Metab. Res. 2007) 3 23
  4. Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males. (PMID: 16687568) Christensen G.L. … Carrell D.T. (Mol. Hum. Reprod. 2006) 3 23
  5. Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha. (PMID: 16893891) Gautier-Stein A. … Rajas F. (J. Biol. Chem. 2006) 3 23

Products for CREM Gene

Sources for CREM Gene

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