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Aliases for CREM Gene

Aliases for CREM Gene

  • CAMP Responsive Element Modulator 2 3
  • ICER 3 4
  • Inducible CAMP Early Repressor ICER 3
  • CAMP Response Element Modulator 3
  • Inducible CAMP Early Repressor 4
  • CREM 2alpha-B Protein 3
  • CREM 2beta-A Protein 3
  • HCREM-2 3
  • CREM-2 3

External Ids for CREM Gene

Previous GeneCards Identifiers for CREM Gene

  • GC10P035163
  • GC10P035566
  • GC10P035419
  • GC10P035455
  • GC10P035415

Summaries for CREM Gene

Entrez Gene Summary for CREM Gene

  • This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREM Gene

CREM (CAMP Responsive Element Modulator) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and SIDS Susceptibility Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot for CREM Gene

  • Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).

  • Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Wiki entry for CREM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREM Gene

Genomics for CREM Gene

Regulatory Elements for CREM Gene

Transcription factor binding sites by QIAGEN in the CREM gene promoter:

Genomic Location for CREM Gene

Chromosome:
10
Start:
35,126,791 bp from pter
End:
35,212,958 bp from pter
Size:
86,168 bases
Orientation:
Plus strand

Genomic View for CREM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREM Gene

Proteins for CREM Gene

neXtProt entry for CREM Gene

Proteomics data for CREM Gene at MOPED

Post-translational modifications for CREM Gene

No data available for DME Specific Peptides for CREM Gene

Domains & Families for CREM Gene

Gene Families for CREM Gene

Graphical View of Domain Structure for InterPro Entry

Q03060

UniProtKB/Swiss-Prot:

CREM_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Contains 1 KID (kinase-inducible) domain.
Family:
  • Belongs to the bZIP family.
genes like me logo Genes that share domains with CREM: view

Function for CREM Gene

Molecular function for CREM Gene

GENATLAS Biochemistry:
cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor) acting as repressor,regulated in a circadian manner in the pineal gland
UniProtKB/Swiss-Prot Function:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
UniProtKB/Swiss-Prot Function:
Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

Gene Ontology (GO) - Molecular Function for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding NAS 7916662
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10373550
GO:0008140 cAMP response element binding protein binding NAS 8206879
genes like me logo Genes that share ontologies with CREM: view
genes like me logo Genes that share phenotypes with CREM: view

Animal Models for CREM Gene

MGI Knock Outs for CREM:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CREM Gene

Localization for CREM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREM Gene

Nucleus.
Isoform 6: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREM Gene COMPARTMENTS Subcellular localization image for CREM gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8206879
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CREM: view

Pathways & Interactions for CREM Gene

genes like me logo Genes that share pathways with CREM: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cardiotoxicity in human,mouse,rat
    • Synaptic Plasticity in human,mouse,rat

Gene Ontology (GO) - Biological Process for CREM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 7916662
GO:0006631 fatty acid metabolic process IEA --
GO:0006687 glycosphingolipid metabolic process IEA --
genes like me logo Genes that share ontologies with CREM: view

No data available for SIGNOR curated interactions for CREM Gene

Drugs & Compounds for CREM Gene

(6) Drugs for CREM Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved Nutra Antagonist Melatonin receptors MT inhibitor 215
cyclic amp Experimental Pharma 0
Forskolin Experimental Pharma 0
leucine Nutra 93
serine Nutra 420

(2) Additional Compounds for CREM Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
adenylate
glutamate
genes like me logo Genes that share compounds with CREM: view

Transcripts for CREM Gene

Unigene Clusters for CREM Gene

CAMP responsive element modulator:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREM Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP10: - - - -
SP11: - - - - - - - - - - -
SP12: -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -

ExUns: 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c · 19d · 19e · 19f
SP1: - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - -
SP17: - - - - -
SP18: - - - - - - - - - - -
SP19: - - - -
SP20: - - -
SP21: - - - - - - - -
SP22: - -
SP23: -
SP24: - - - - - -
SP25:

Relevant External Links for CREM Gene

GeneLoc Exon Structure for
CREM
ECgene alternative splicing isoforms for
CREM

Expression for CREM Gene

mRNA expression in normal human tissues for CREM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREM Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for CREM Gene

This gene is overexpressed in Testis (54.2) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREM Gene



SOURCE GeneReport for Unigene cluster for CREM Gene Hs.200250

mRNA Expression by UniProt/SwissProt for CREM Gene

Q03060-CREM_HUMAN
Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
genes like me logo Genes that share expression patterns with CREM: view

Protein tissue co-expression partners for CREM Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CREM Gene

This gene was present in the common ancestor of animals.

Orthologs for CREM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CREM 35
  • 88.74 (n)
  • 89.3 (a)
CREM 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREM 35
  • 94.94 (n)
  • 93.64 (a)
CREM 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crem 35
  • 92.34 (n)
  • 91.89 (a)
Crem 16
Crem 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CREM 35
  • 94.98 (n)
  • 95.32 (a)
CREM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crem 35
  • 92.57 (n)
  • 91.89 (a)
oppossum
(Monodelphis domestica)
Mammalia CREM 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREM 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CREM 35
  • 73.81 (n)
  • 70.07 (a)
CREM 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREM 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crema 35
  • 67.26 (n)
  • 72.12 (a)
crema 36
  • 55 (a)
ManyToMany
cremb 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3621 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 36
  • 42 (a)
OneToMany
Species with no ortholog for CREM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CREM Gene

ENSEMBL:
Gene Tree for CREM (if available)
TreeFam:
Gene Tree for CREM (if available)

Paralogs for CREM Gene

Paralogs for CREM Gene

genes like me logo Genes that share paralogs with CREM: view

Variants for CREM Gene

Sequence variations from dbSNP and Humsavar for CREM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs877779 -- 35,150,261(-) GCTTC(A/G)GCACA intron-variant
rs878264 -- 35,151,653(-) CTCAC(A/G)CCAGT intron-variant
rs1057108 -- 35,196,021(+) AGTGG(G/T)TGTCT intron-variant, utr-variant-5-prime, nc-transcript-variant
rs1064262 -- 35,211,704(+) AAATG(C/T)CTGGA synonymous-codon, reference, utr-variant-3-prime, nc-transcript-variant
rs1064263 -- 35,211,794(+) AAAAC(A/T)GATTA reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CREM Gene

Variant ID Type Subtype PubMed ID
nsv895019 CNV Gain 21882294
nsv895020 CNV Gain 21882294
esv2735328 CNV Deletion 23290073
dgv108e201 CNV Deletion 23290073
esv2735362 CNV Deletion 23290073
nsv820199 CNV Loss 19587683
esv2668859 CNV Deletion 23128226
esv2659986 CNV Deletion 23128226

Variation tolerance for CREM Gene

Residual Variation Intolerance Score: 45.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.31; 76.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREM Gene

HapMap Linkage Disequilibrium report
CREM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREM Gene

Disorders for CREM Gene

Relevant External Links for CREM

Genetic Association Database (GAD)
CREM
Human Genome Epidemiology (HuGE) Navigator
CREM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREM
genes like me logo Genes that share disorders with CREM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREM Gene

Publications for CREM Gene

  1. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PMID: 7916662) Masquilier D. … Sassone-Corsi P. (Cell Growth Differ. 1993) 2 23 67
  2. Functional cooperation between CREM and GCNF directs gene expression in haploid male germ cells. (PMID: 20071744) Rajkovic M. … Weitzel J.M. (Nucleic Acids Res. 2010) 23 67
  3. CREM mutations and ADHD symptoms. (PMID: 19201103) Lahti T.A. … Partonen T. (Med. Hypotheses 2009) 23 67
  4. Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities. (PMID: 19269352) GA^mez-MartA-n D. … Alcocer-Varela J. (Autoimmun Rev 2009) 23 67
  5. Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. (PMID: 18305237) Green T.A. … Nestler E.J. (J. Neurosci. 2008) 23 67

Products for CREM Gene

Sources for CREM Gene

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