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CREM Gene

protein-coding   GIFtS: 63
GCID: GC10P035415

CAMP Responsive Element Modulator

  Search for CREM
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Modulator1 2     CREM 2alpha-B Protein2
ICER2 3     CREM 2beta-A Protein2
CREM-22     hCREM-22
CAMP Response Element Modulator2     Inducible CAMP Early Repressor ICER2
CAMP-Responsive Element Modulator2     Inducible CAMP Early Repressor3

External Ids:    HGNC: 23521   Entrez Gene: 13902   Ensembl: ENSG000000957947   OMIM: 1238125   UniProtKB: Q030603   

Export aliases for CREM gene to outside databases

Previous GC identifers: GC10P035163 GC10P035566 GC10P035419 GC10P035455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREM Gene:
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and
cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic
cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this
gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript
variants encoding several different isoforms have been found for this gene, with some of them functioning as
activators and some as repressors of transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREM Gene:
CREM (cAMP responsive element modulator) is a protein-coding gene. GO annotations related to this gene include cAMP response element binding protein binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060
Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral
and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in
spermatogenesis and is involved in spermatid maturation (By similarity)

Gene Wiki entry for CREM (CAMP responsive element modulator) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREM gene promoter:
         ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): CREM promoter sequence
   Search Chromatin IP Primers for CREM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.21   Ensembl cytogenetic band:  10p11.21   HGNC cytogenetic band: 10p12.1-p11.1

CREM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREM gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P035415:  view genomic region     (about GC identifiers)

Start:
35,415,719 bp from pter      End:
35,501,886 bp from pter
Size:
86,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060 (See protein sequence)
Recommended Name: cAMP-responsive element modulator  
Size: 361 amino acids; 38940 Da
Subunit: Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34
Sequence caution: Sequence=AAB03751.1; Type=Erroneous termination; Positions=361; Note=Translated as Tyr;
Sequence=AAF68266.2; Type=Erroneous gene model prediction;
Secondary accessions: A8K014 A8K3J7 A8K6A1 A8MPQ2 B4DXC1 C9J785 C9JZ10 E9PAR4 E9PHM1 O75519
Q14501 Q14503 Q14504 Q14505 Q14506 Q15731 Q16114 Q16116 Q5T9H7 Q5W1A6 Q5W1A7 Q5W1A8 Q5W1A9
Q5W1B0 Q5W1B2 Q7Z2Q6 Q8IVD4 Q96AG7 Q9NZ98 Q9NZ99 Q9NZB9
Alternative promoter usage, Alternative splicing: 29 isoforms:  Q03060-5   Q03060-1   Q03060-6   Q03060-2   Q03060-7   Q03060-8   Q03060-9   Q03060-10   
Q03060-11   Q03060-12   Q03060-13   Q03060-14   Q03060-15   Q03060-16   Q03060-17   Q03060-19   
Q03060-20   Q03060-21   Q03060-22   Q03060-23   Q03060-24   Q03060-25   Q03060-26   Q03060-27   
Q03060-28   Q03060-29   Q03060-30   Q03060-31   Q03060-32   (Produced by alternative splicing. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CREM: NX_Q03060

Explore proteomics data for CREM at MOPED

Post-translational modifications: 

  • Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome1
  • Stimulated by phosphorylation (By similarity)1
  • Ubiquitination2 at Lys337
  • Modification sites at PhosphoSitePlus

  • See CREM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (26 alternative transcripts): 
    NP_001254491.1  NP_001254492.1  NP_001254493.1  NP_001254494.1  NP_001254495.1  NP_001254496.1  NP_001254497.1  NP_001254498.1  
    NP_001254499.1  NP_001872.3  NP_853549.1  NP_874386.1  NP_874387.1  NP_874388.1  NP_874389.1  NP_874390.1  
    NP_874392.1  NP_874393.1  NP_877570.1  NP_877571.1  NP_877572.1  NP_877573.1  NP_898829.1  NP_898830.1  
    NP_898831.1  NP_898883.1  

    ENSEMBL proteins: 
     ENSP00000419018   ENSP00000363853   ENSP00000363858   ENSP00000417058   ENSP00000420453  
     ENSP00000393538   ENSP00000473519   ENSP00000420437   ENSP00000346804   ENSP00000419924  
     ENSP00000403938   ENSP00000265372   ENSP00000418798   ENSP00000337138   ENSP00000363866  
     ENSP00000420511   ENSP00000345384   ENSP00000418450   ENSP00000354593   ENSP00000417165  
     ENSP00000379225   ENSP00000417399   ENSP00000418336   ENSP00000341875   ENSP00000417130  
     ENSP00000419684   ENSP00000417807   ENSP00000420681   ENSP00000417460   ENSP00000349387  
     ENSP00000419075   ENSP00000417562   ENSP00000419810   ENSP00000344365   ENSP00000417327  
     ENSP00000379232   ENSP00000333055   ENSP00000409220   ENSP00000363860  

    CREM Human Recombinant Protein Products:

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    OriGene Purified Proteins for CREM
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    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for CREM
    Novus Biologicals CREM Proteins
    Novus Biologicals CREM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CREM

     
    Search eBioscience for Proteins for CREM 

    CREM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CREM
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    LSBio Antibodies in human, mouse, rat for CREM

    CREM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CREM
    Cloud-Clone Corp. CLIAs for CREM
    Search eBioscience for ELISAs for CREM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR003102 Coactivator_CBP_pKID
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry Q03060

    ProtoNet protein and cluster: Q03060

    3 Blocks protein domains:
    IPB001630 cAMP response element binding (CREB) protein signature
    IPB003102 Coactivator CBP
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 KID (kinase-inducible) domain


    Find genes that share domains with CREM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREM_HUMAN, Q03060
    Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral
    and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in
    spermatogenesis and is involved in spermatid maturation (By similarity)

         Genatlas biochemistry entry for CREM:
    cAMP response element modulator,playing a key role within the hypopituitary-pituitary-gonadal axis,involved lin
    spermiogenesis,including a truncated isoform (early response repressor ICER=inducible cAMP early repressor)
    acting as repressor,regulated in a circadian manner in the pineal gland

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS7916662
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10373550
    GO:0008140cAMP response element binding protein binding NAS8206879
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with CREM           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crem):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  liver/biliary system 
     mortality/aging  muscle  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with CREM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CREM: Cremtm1Saco Cremtm1.1Endo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CREM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREM

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CREM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREM (see all 18):
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-3942-5p hsa-miR-202 hsa-miR-624 hsa-miR-548x hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCREM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CREM
    Predesigned siRNA for gene silencing in human, mouse, rat CREM

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 21): CREM (NM_181571)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREM

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CREM 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREM_HUMAN, Q03060: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8206879
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with CREM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREM About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2DREAM Repression and Dynorphin Expression
    DREAM Repression and Dynorphin Expression0.44
    3Transcription CREM signaling in testis
    Transcription CREM signaling in testis
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Selenium Metabolism and Selenoproteins
    Selenium Metabolism and Selenoproteins


    Find genes that share SuperPaths with CREM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CREM (see all 6)
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    DREAM Repression and Dynorphin Expression
    Activation of cAMP-Dependent PKA

    1 GeneGo (Thomson Reuters) Pathway for CREM
        Transcription CREM signaling in testis

    2 BioSystems Pathways for CREM
        Selenium Metabolism and Selenoproteins
    SIDS Susceptibility Pathways


    2 Kegg Pathways  (Kegg details for CREM):
        Adrenergic signaling in cardiomyocytes
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CREM: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Synaptic Plasticity in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CREM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREM (Q030603 ENSP000002653724) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF1P188463, ENSP000002620534I2D: score=5 STRING: ENSP00000262053
    SPI1P179473, ENSP000002271634I2D: score=3 STRING: ENSP00000227163
    TAF4O002683, ENSP000002529964I2D: score=3 STRING: ENSP00000252996
    CSNK2A2P197843, ENSP000002625064I2D: score=2 STRING: ENSP00000262506
    GSK3AP498403, ENSP000002223304I2D: score=2 STRING: ENSP00000222330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS7916662
    GO:0006687glycosphingolipid metabolic process IEA--
    GO:0007165signal transduction TAS7916662
    GO:0007275multicellular organismal development IEA--

    Find genes that share ontologies with CREM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREM

    1 HMDB Compound for CREM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    8 Novoseek inferred chemical compound relationships for CREM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 63 25 7916662 (2), 10871653 (2), 9517483 (2), 11344215 (2) (see all 11)
    leucine 49.3 3 14713288 (1), 10525188 (1)
    melatonin 44.9 6 10752062 (2), 9618898 (2)
    forskolin 41.2 6 17712720 (1), 9544985 (1), 10660591 (1), 9545284 (1) (see all 5)
    adenylate 18.7 1 10697414 (1)
    serine 15.8 1 8414969 (1)
    tyrosine 0 1 10812201 (1)
    glutamate 0 2 9517483 (2)



    Find genes that share compounds with CREM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CREM gene (30 alternative transcripts): 
    NM_001267562.1  NM_001267563.1  NM_001267564.1  NM_001267565.1  NM_001267566.1  NM_001267567.1  NM_001267568.1  NM_001267569.1  
    NM_001267570.1  NM_001881.3  NM_181571.2  NM_182717.1  NM_182718.1  NM_182719.1  NM_182720.1  NM_182721.1  
    NM_182723.1  NM_182724.1  NM_182769.2  NM_182770.2  NM_182771.1  NM_182772.1  NM_183011.1  NM_183012.1  
    NM_183013.2  NM_183060.2  NM_182722.1  NM_182725.1  NM_182850.2  NM_182853.2  

    Unigene Cluster for CREM:

    CAMP responsive element modulator
    Hs.200250  [show with all ESTs]
    Unigene Representative Sequence: AB209533
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 50):
    ENST00000474362 ENST00000374721 ENST00000496626 ENST00000482646 ENST00000489388
    ENST00000374726(uc001ixx.3) ENST00000461968 ENST00000490460 ENST00000466251
    ENST00000482633 ENST00000495960 ENST00000429130 ENST00000469949 ENST00000460270
    ENST00000496019 ENST00000354759 ENST00000489321 ENST00000427847
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CREM (see all 18):
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-3942-5p hsa-miR-202 hsa-miR-624 hsa-miR-548x hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidCREM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREM
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 21): CREM (NM_181571)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CREM

    Additional mRNA sequence: 

    AB209533.1 AF069065.1 AF417233.1 AF417234.1 AK289379.1 AK290612.1 AK291566.1 AK301906.1 
    AY292864.1 BC017117.1 BC041810.1 BC066342.1 BC090051.1 NR_051971.1 NR_051972.1 NR_051973.1 
    NR_051974.1 NR_051975.1 S68134.1 S68271.1 U44836.1 Y08959.1 Z15159.1 

    Selected DOTS entries (see all 42):

    DT.107647  DT.92437248  DT.100726650  DT.99984774  DT.92437260  DT.92437247  DT.86821221  DT.100687398 
    DT.101981359  DT.100689650  DT.427387  DT.101980105  DT.101980377  DT.101981362  DT.101981360  DT.101983744 
    DT.86821220  DT.121286410  DT.454725  DT.91888806  DT.92437262  DT.100763703  DT.101983746  DT.121286444 

    Selected AceView cDNA sequences (see all 280):

    F10646 BC017117 BI966160 NM_182769 AI568927 AI446334 BC066342 NM_182718 
    NM_183013 CR621145 NM_183011 NM_183012 NM_182770 CR614277 BX101868 CD679354 
    BI755263 NM_182723 NM_182772 AI090975 AI659415 AI749200 BG170910 NM_182717 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CREM (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ·
    SP1:                                                        -                 -     -     -     -     -     -     -     -                 -     -     -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                        -     -           -     -     -     -     -     -     -     -                 -     -     -     -   
    SP4:                                                        -     -     -     -     -     -     -     -     -     -     -                 -     -     -     -   
    SP5:                                                        -     -           -     -     -     -     -     -     -     -                                       

    ExUns: 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d · 18e ^ 19a · 19b · 19c · 19d · 19e · 19f
    SP1:  -     -     -     -     -     -     -                                                                                       
    SP2:  -           -     -     -     -     -     -           -     -     -     -     -     -                                       
    SP3:  -                                                                                                                           
    SP4:  -     -     -     -     -     -     -     -           -     -     -     -     -     -                                       
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CREM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CREM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAGTTGCT
    CREM Expression
    About this image


    CREM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatid Seminiferous Tubules
             Testis Interstitium
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)
    CREM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.200250

    UniProtKB/Swiss-Prot: CREM_HUMAN, Q03060
    Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator
    form in testes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CREM: 
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              Synaptic Plasticity in human mouse rat
              Cardiotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREM gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crem1 , 5 cAMP responsive element modulator1, 5 92.34(n)1
    91.89(a)1
      18 (2.14 cM)5
    129161  NM_001271506.11  NP_001258435.11 
     32660485 
    chicken
    (Gallus gallus)
    Aves CREM1 cAMP responsive element modulator 73.81(n)
    70.07(a)
      378903  NM_001278132.1  NP_001265061.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREM6
    cAMP responsive element modulator
    67(a)
    1 ↔ 1
    6(10823012-10846853)
    zebrafish
    (Danio rerio)
    Actinopterygii crema1 cAMP responsive element modulator a 67.26(n)
    72.12(a)
      555432  XM_677932.6  XP_683024.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebB-17A6
    Cyclic-AMP response element binding protein B at 1...
    22(a)
    1 → many
    X(18260733-18271897)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-16
    Protein CRH-1, isoform g
    20(a)
    1 → many
    III(11657738-11693837) WBGene00000793


    ENSEMBL Gene Tree for CREM (if available)
    TreeFam Gene Tree for CREM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREM gene
    ATF12  CREB12  
    5 SIMAP similar genes for CREM using alignment to 17 protein entries:     CREM_HUMAN (see all proteins):
    CREB1    ATF1    EWSR1/ATF1 fusion    CREB3L4    CREB3L1

    Find genes that share paralogs with CREM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CREM (see all 1816)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345690481,2
    C--35152556(+) AAAAA-/AG/G  
            
    AAAAA
    11 -- int10--------
    rs122512031,2
    A--35158285(+) GCTTGA/GAAGTG 11 -- int10--------
    rs1809766021,2
    --35158344(+) CTGAGA/GGCTTG 11 -- int10--------
    rs1136590891,2
    C--35164667(+) CCCACAACT/-  
            
    CAACT
    11 -- int11Minor allele frequency- -:0.50CSA 2
    rs110101121,2
    C,F--35177254(+) CTGGAG/TTGCAG 15 -- int11Minor allele frequency- T:0.50WA 2
    rs715233651,2
    C--35178402(+) AAGCC-/CT/TT 
            
    TTTTT
    15 -- int11NA 2
    rs345326461,2
    C--35192350(+) ACTTC-/TTTTTT 16 -- int10--------
    rs1883339771,2
    --35194382(+) TTAATA/GTATAA 16 -- int10--------
    rs1931876811,2
    --35194395(+) TATATA/TATATA 16 -- int10--------
    rs1379928281,2
    C--35196434(+) GTTTG-/TTTTTT 16 -- int10--------

    HapMap Linkage Disequilibrium report for CREM (35415719 - 35501886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CREM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735328CNV Deletion23290073
    esv2735362CNV Deletion23290073
    esv2659986CNV Deletion23128226
    dgv108e201CNV Deletion23290073
    esv2668859CNV Deletion23128226
    nsv820199CNV Loss19587683
    nsv895020CNV Gain21882294
    nsv895019CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREM
    DNA2.0 Custom Variant and Variant Library Synthesis for CREM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123812    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CREM:
    Male infertility

    Find genes that share disorders with CREM           About GenesLikeMe

    4 Novoseek inferred disease relationships for CREM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    infertility 41.9 3 15705296 (1), 8600391 (1), 14965334 (1)
    infertility male 22.2 2 9510006 (1)
    lupus erythematosus systemic 5.36 2 15841182 (2)
    tumors 0 2 9545284 (2)

    Genetic Association Database (GAD): CREM
    Human Genome Epidemiology (HuGE) Navigator: CREM (11 documents)

    Export disorders for CREM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREM gene, integrated from 10 sources (see all 206):
    (articles sorted by number of sources associating them with CREM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. (PubMed id 7916662)1, 2, 3, 9 Masquilier D.... Sassone-Corsi P. (Cell Growth Differ. 1993)
    2. Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. (PubMed id 1461747)1, 2, 3 Meyer T.E. and Habener J.F. (Nucleic Acids Res. 1992)
    3. Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. (PubMed id 12397208)1, 2, 9 Gellersen B.... Behr R. (Mol. Hum. Reprod. 2002)
    4. Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. (PubMed id 10373550)1, 2, 9 Pati D.... Plon S.E. (Mol. Cell. Biol. 1999)
    5. Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. (PubMed id 8206879)1, 2, 9 Fujimoto T.... Yoshida M. (J. Biochem. 1994)
    6. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    7. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. (PubMed id 18984674)1, 4 Argyropoulos G....Rankinen T. (Physiol. Genomics 2009)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility? (PubMed id 16143638)1, 2 Vouk K.... Rozman D. (Mol. Hum. Reprod. 2005)
    10. Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis. (PubMed id 14511788)1, 2 Bloecher S.... Steger K. (Theriogenology 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1390 HGNC: 2352 AceView: CREM Ensembl:ENSG00000095794 euGenes: HUgn1390
    ECgene: CREM Kegg: 1390 H-InvDB: CREM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CREM gene:
    Search GeneIP for patents involving CREM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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