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CRELD2 Gene

protein-coding   GIFtS: 58
GCID: GC22P050311

Cysteine-Rich With EGF-Like Domains 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine-Rich With EGF-Like Domains 21 2
Cysteine-Rich With EGF-Like Domain Protein 22

External Ids:    HGNC: 281501   Entrez Gene: 791742   Ensembl: ENSG000001841647   OMIM: 6071715   UniProtKB: Q6UXH13   

Export aliases for CRELD2 gene to outside databases

Previous GC identifers: GC22P048634 GC22P048698 GC22P033259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CRELD2 Gene:
CRELD2 (cysteine-rich with EGF-like domains 2) is a protein-coding gene. Diseases associated with CRELD2 include schmid metaphyseal chondrodysplasia, and cannabis dependence. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CRELD1.

UniProtKB/Swiss-Prot: CREL2_HUMAN, Q6UXH1
Function: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor

Gene Wiki entry for CRELD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRELD2 gene promoter:
         COUP-TF1   AML1a   COUP   Pax-2   HNF-4alpha2   Pax-2a   Tal-1beta   HNF-4alpha1   COUP-TF   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRELD2 promoter sequence
   Search Chromatin IP Primers for CRELD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRELD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

CRELD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRELD2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P050311:  view genomic region     (about GC identifiers)

Start:
50,311,815 bp from pter      End:
50,321,188 bp from pter
Size:
9,374 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CREL2_HUMAN, Q6UXH1 (See protein sequence)
Recommended Name: Cysteine-rich with EGF-like domain protein 2 precursor  
Size: 353 amino acids; 38192 Da
Subunit: May interact with CHRNA4
Developmental stage: Expressed in all fetal tissues tested
Secondary accessions: A5GZA2 A5GZA3 A5GZA4 A5GZA5 A5GZA6 Q4W0V0 Q86UC0 Q9BU47
Alternative splicing: 6 isoforms:  Q6UXH1-1   Q6UXH1-2   Q6UXH1-3   Q6UXH1-4   Q6UXH1-5   Q6UXH1-6   (Minor isoform)

Explore the universe of human proteins at neXtProt for CRELD2: NX_Q6UXH1

Explore proteomics data for CRELD2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr58, Asn190, Asn251
  • Modification sites at PhosphoSitePlus

  • See CRELD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128573.1  NP_001271246.1  NP_001271247.1  NP_077300.3  

    ENSEMBL proteins: 
     ENSP00000387769   ENSP00000383938   ENSP00000332223   ENSP00000386034   ENSP00000384111  

    CRELD2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CRELD2
    OriGene MassSpec for CRELD2
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    GenScript Custom Purified and Recombinant Proteins Services for CRELD2
    Novus Biologicals CRELD2 Proteins
    Novus Biologicals CRELD2 Lysates
    Sino Biological Recombinant Protein for CRELD2
    Sino Biological Cell Lysate for CRELD2
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    Cloud-Clone Corp. Proteins for CRELD2

    CRELD2 Antibody Products:

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    Cloud-Clone Corp. CLIAs for CRELD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR006212 Furin_repeat
     IPR000742 EG-like_dom
     IPR021852 DUF3456
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q6UXH1

    ProtoNet protein and cluster: Q6UXH1

    2 Blocks protein domains:
    IPB006210 Type I EGF
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: CREL2_HUMAN, Q6UXH1
    Similarity: Belongs to the CRELD family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 2 FU (furin-like) repeats


    CRELD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREL2_HUMAN, Q6UXH1
    Function: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    CRELD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRELD2:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Creld2 (no phenotypes)

    CRELD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Creld2tm1Lex for CRELD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRELD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CRELD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRELD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRELD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRELD2:
    hsa-mir-93-5p (MIRT048889), hsa-mir-1 (MIRT023504)

    Block miRNA regulation of human, mouse, rat CRELD2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CRELD2:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-32* hsa-miR-556-3p hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidCRELD2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CRELD2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CRELD2

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    GenScript: all cDNA clones in your preferred vector (see all 2): CRELD2 (NM_001135101)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRELD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRELD2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRELD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRELD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRELD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREL2_HUMAN, Q6UXH1: Secreted (Potential). Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    golgi apparatus2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--

    CRELD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRELD2
    Interactions:

        Search GeneGlobe Interaction Network for CRELD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CRELD2 (Q6UXH11, 2, 3 ENSP000003839384) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253033 I2D: score=1 
    ENSG00000206406P678702, 3MINT-8253033 I2D: score=1 
    ENSG00000224398P678702, 3MINT-8253033 I2D: score=1 
    ENSG00000224774P678702, 3MINT-8253033 I2D: score=1 
    ENSG00000228875P678702, 3MINT-8253033 I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRELD2 (CREL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CRELD2 gene (4 alternative transcripts): 
    NM_001135101.2  NM_001284317.1  NM_001284318.1  NM_024324.4  

    Unigene Cluster for CRELD2:

    Cysteine-rich with EGF-like domains 2
    Hs.211282  [show with all ESTs]
    Unigene Representative Sequence: AL713788
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450207 ENST00000404488(uc003biz.3 uc010hal.2 uc003bja.2 uc010hak.2 uc010ham.2)
    ENST00000328268 ENST00000483652(uc010haj.3) ENST00000407217 ENST00000403427
    ENST00000482956 ENST00000498354 ENST00000462253 ENST00000444954 ENST00000487969

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRELD2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CRELD2:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-32* hsa-miR-556-3p hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidCRELD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRELD2
    Predesigned siRNA for gene silencing in human, mouse, rat CRELD2
    Clone
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    OriGene clones in human, mouse for CRELD2 (see all 13)
    OriGene ORF clones in mouse, rat for CRELD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CRELD2 (NM_001135101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRELD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRELD2
    Primer
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    OriGene qPCR primer pairs and template standards for CRELD2
    OriGene qSTAR qPCR primer pairs in human, mouse for CRELD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRELD2
      QuantiTect SYBR Green Assays in human, mouse, rat CRELD2
      QuantiFast Probe-based Assays in human, mouse, rat CRELD2

    Additional mRNA sequence: 

    AJ968414.1 AK126178.1 AK225930.1 AK308535.1 AK308692.1 AL713788.1 AY358355.1 BC002894.1 
    BC050675.1 DQ470676.1 DQ470677.1 DQ470678.1 DQ470679.1 DQ470680.1 

    9 DOTS entries:

    DT.314504  DT.92432847  DT.95224402  DT.99931665  DT.100776550  DT.100029921  DT.95250183  DT.100672886 
    DT.100776552 

    Selected AceView cDNA sequences (see all 212):

    N28564 BE796766 AI264807 BE019348 AI673056 BU931834 BU072575 BM311061 
    AW118291 CD671562 CD671563 AA310217 BE250199 AY358355 BE297368 F08850 
    BM552953 BE382658 CA436845 BQ687800 BM311651 BU625731 BQ772339 CA487845 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRELD2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                                      -           -     -     -                 -                     
    SP2:                                      -           -     -     -                 -     -               
    SP3:                                      -           -     -     -                                       
    SP4:                                      -           -                                                   
    SP5:                                      -           -                                                   


    ECgene alternative splicing isoforms for CRELD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRELD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGGCTACT
    CRELD2 Expression
    About this image


    CRELD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CRELD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRELD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211282

    UniProtKB/Swiss-Prot: CREL2_HUMAN, Q6UXH1
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRELD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRELD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creld21 , 5 cysteine-rich with EGF-like domains 21, 5 79.2(n)1
    77.68(a)1
      15 (44.31 cM)5
    767371  NM_029720.21  NP_083996.11 
     888196465 
    chicken
    (Gallus gallus)
    Aves CRELD21 cysteine-rich with EGF-like domains 2 63.49(n)
    62.46(a)
      417735  NM_001199497.1  NP_001186426.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRELD26
    cysteine-rich with EGF-like domains 2
    55(a)
    1 ↔ 1
    GL343277.1(235162-255882)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242892 Xenopus laevis transcribed sequence with weak similarity more 72.01(n)    CB206700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663832 hypothetical protein MGC66383 70.62(n)   393495  BC055626.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113771 CG11377 54.74(n)
    45.38(a)
      33166  NM_134646.4  NP_608490.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F09E8.21 F09E8.2 48.47(n)
    42.36(a)
      178267  NM_070129.5  NP_502530.1 


    ENSEMBL Gene Tree for CRELD2 (if available)
    TreeFam Gene Tree for CRELD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRELD2 gene
    CRELD12  
    2 SIMAP similar genes for CRELD2 using alignment to 2 protein entries:     CREL2_HUMAN (see all proteins):
    DKFZp667O055    CRELD1

    CRELD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRELD2 (see all 343)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483030411,2
    C--50314150(+) TAATTC/GAGGGG 2 -- int10--------
    rs1849657551,2
    --50314218(+) GACCTA/GTCCAG 2 -- int10--------
    rs119129091,2
    C,F,H--50314247(+) ACAGAG/AGTGAC 2 -- int11Minor allele frequency- A:0.06WA 118
    rs96163901,2
    C,F,A,H--50314289(+) AGAGCG/CCAGGG 2 -- int19Minor allele frequency- C:0.21WA NA CSA EA 370
    rs734439741,2
    C,F--50314316(+) GGCTGG/AGCACA 2 -- int15Minor allele frequency- A:0.09WA CSA NA EA 362
    rs72844171,2
    C,F,A,H--50314346(+) GTGCCA/GAGGGA 2 -- int110Minor allele frequency- G:0.44NA WA CSA EA 371
    rs1414527961,2
    C--50314482(+) ACCATC/TAGCCT 2 -- int10--------
    rs1156270221,2
    C,F--50314564(+) CCCCGC/TGCCTG 2 -- int11Minor allele frequency- T:0.23WA 118
    rs1457213151,2
    --50314565(+) CCCGCA/GCCTGA 2 -- int10--------
    rs96163911,2
    C,F,A,H--50314573(+) TGACGC/TGTCAG 2 -- int16Minor allele frequency- T:0.15NA WA CSA EA 364

    HapMap Linkage Disequilibrium report for CRELD2 (50311815 - 50321188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CRELD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724722CNV Deletion23290073
    dgv5050n71CNV Loss21882294
    dgv5049n71CNV Loss21882294
    nsv915495CNV Loss21882294
    nsv915506CNV Loss21882294
    nsv471221CNV Loss18288195
    dgv5046n71CNV Loss21882294
    nsv915508CNV Loss21882294
    dgv5051n71CNV Loss21882294
    nsv915512CNV Gain21882294

    Human Gene Mutation Database (HGMD): CRELD2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRELD2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607171    OMIM disorders: --

    10 diseases for CRELD2:    
    About MalaCards
    schmid metaphyseal chondrodysplasia    cannabis dependence    metaphyseal dysplasia    multiple epiphyseal dysplasia
    chondrodysplasia    tonsillitis    malaria    cerebritis
    neuronitis    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for CRELD2:
    Metaphyseal dysplasia     Multiple epiphyseal dysplasia

    CRELD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRELD2

    Export disorders for CRELD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRELD2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CRELD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region. (PubMed id 16919896)1, 2, 9 Maslen C.L....Olson S.B. (Gene 2006)
    2. The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. (PubMed id 16238698)1, 2 Ortiz J.A.... Criado M. (J. Neurochem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. (PubMed id 12137942)1, 3 Rupp P.A....Maslen C.L. (Gene 2002)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. A genome-wide association study of DSM-IV cannabis dependence. (PubMed id 21668797)4 Agrawal A....Bierut L.J. (Addict Biol 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79174 HGNC: 28150 AceView: MGC11256 Ensembl:ENSG00000184164 euGenes: HUgn79174
    ECgene: CRELD2 H-InvDB: CRELD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRELD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRELD2 gene:
    Search GeneIP for patents involving CRELD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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