CRELD1 Gene

Aliases
for CRELD1 gene

Previous GC identifers: GC03U990184 GC03P009915 GC03P009967 GC03P009951 GC03P009952 GC03P009953 GC03P009913

Summaries
for CRELD1 gene

Genomic Views
for CRELD1 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: CRELD1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRELD1

CRELD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009975:  view genomic region     (about GC identifiers)

Proteins
for CRELD1 gene

Explore the universe of human proteins at neXtProt for CRELD1: NX_Q96HD1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CRELD1
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CRELD1 OriGene Protein Over-expression Lysate (see all 4): CRELD1 OriGene Custom Protein Services for CRELD1
	GenScript Custom Purified and Recombinant Proteins Services for CRELD1
	Novus Biologicals CRELD1 Protein Novus Biologicals CRELD1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CRELD1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CRELD1
	Browse OriGene Antibodies OriGene Custom Antibody Services for CRELD1
	GenScript Custom Superior Antibodies Services for CRELD1
	Novus Biologicals CRELD1 Antibodies
	Search for Antibodies for CRELD1 at Abcam
	Uscn Antibodies for CRELD1
	Search ThermoFisher Antibodies for CRELD1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CRELD1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRELD1

Protein Domains /
Families
for CRELD1 gene

ProtoNet protein and cluster: Q96HD1

Function
for CRELD1 gene

miRNA Products:		miRTarBase miRNAs that target CRELD1: hsa-mir-346 (MIRT004230)
		OriGene 3'-UTR Clone (see all 3): CRELD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRELD1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CRELD1 (see all 13):
		hsa-miR-4324 hsa-miR-198 hsa-miR-1301 hsa-miR-103a hsa-miR-544b hsa-miR-885-3p hsa-miR-377 hsa-miR-1207-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CRELD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRELD1 (see all 7) OriGene shRNA RFP: CRELD1 OriGene siRNA: CRELD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRELD1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CRELD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRELD1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRELD1 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CRELD1 (NM_015513)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRELD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRELD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CRELD1
		Search LifeMap BioReagents cell lines for CRELD1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRELD1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for CRELD1 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CRELD1 gene

Transcripts
for CRELD1 gene

Expression
for CRELD1 gene

CRELD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Mature follicles (In-vitro growth and ...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRELD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRELD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRELD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRELD1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRELD1

Orthologs
for CRELD1 gene

Paralogs
for CRELD1 gene

Paralogs for CRELD1 gene

CRELD2²  

4 SIMAP similar genes for CRELD1 using alignment to 3 protein entries:     CREL1_HUMAN (see all proteins):

CRELD2    DKFZp667O055    HMCN2    NELL2

CRELD1 for paralogs           About GeneDecksing

Genomic Variants
for CRELD1 gene

10/249 NCBI SNPs in CRELD1 are shown (see all 249)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs289417801,2	C,F,	pathogenic	10769240(+)	CCACCG/ACCTGC	6	/H /R	mis1 ese3		1		NA	4534
rs289420911,2	C,F,	other	10763399(+)	GTTATC/TGCTGC	6	R C	mis1 ese3		3		NA	4554
rs289420921,2	C,	other	10763452(+)	TGAGAC/TAGAGG	6	T I	mis1 ese3		3		NA	4554
rs1129212551,2	C,	--	9910527(+)	CCACCG/CCACCC	7	--	int1		3		CSA WA NA	240
rs592112261,2	C,	--	9911896(+)	TGGGGC/TGGTCG	7	--	ds5001 int1		2		WA	120
rs3883441,2	C	--	9913705(-)	agcatC/Ttttta	3	--	int1		2		MN NA	186
rs755462401,2		--	9915072(+)	TCTATA/GTCCAG	3	--	int1		1		WA	118
rs1115915411,2		--	9915832(+)	CTTGCC/GCTCCA	3	--	int1		2		CSA	3
rs117096891,2	C,H,	--	9916810(+)	tgagcC/Tgagat	3	--	int1		1		NA	2
rs76194101,2	C,	--	9917784(+)	cccccC/Ttttct	3	--	int1 trp3		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRELD1 (9975506 - 9987097 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CRELD1: --
Human Gene Mutation Database (HGMD): CRELD1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRELD1

DNA2.0 Custom Variant and Variant Library Synthesis for CRELD1

Disorders / Diseases
for CRELD1 gene

Publications
for CRELD1 gene

PubMed articles for CRELD1 gene, integrated from 9 sources (see all 26): (articles sorted by number of sources associating them with CRELD1)

Utopia: connect your pdf to the dynamic world of online information

1. Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins. (PubMed id 12137942)^{1, 2, 3} Rupp P.A....Maslen C.L. (2002)
2. Missense mutations in CRELD1 are associated with cardiac atrioventricular septal defects. (PubMed id 12632326)^{1, 2, 9} Robinson S.W.... Maslen C.L. (2003)
3. Analysis of CRELD1 as a candidate 3p25 atrioventicular septal defect locus (AVSD2). (PubMed id 15857420)^{1, 2} Zatyka M.... Maher E.R. (2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
7. Detailed mapping of a congenital heart disease gene in chromosome 3p25. (PubMed id 10922384)^{1, 3} Green E.K....Maher E.R. (2000)
8. Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects. (PubMed id 18076106)^{1, 9} Posch M.G....Berger F. (2008)
9. Specific association of missense mutations in CRELD1 w ith cardiac atrioventricular septal defects in heterotaxy syndrome. (PubMed id 22740159)¹ Zhian S....Maslen C.L. (2012)
10. A maiden report on CRELD1 single-nucleotide polymorph ism association in congenital heart disease patients of Mysore, South India. (PubMed id 21413875)¹ Kusuma L....Ramachandra N.B. (2011)

External Searches for CRELD1 gene

Genome Databases showing CRELD1 gene

Other Databases showing CRELD1 gene

Specialized Databases showing CRELD1 gene

Products
for CRELD1 gene