CREG2 Gene
protein-coding GIFtS: 43
GCID: GC02M101964
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cellular repressor of E1A-stimulated genes 2
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Aliases
for CREG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cellular Repressor Of E1A-Stimulated Genes 21 2 | | Protein CREG22 |
Export aliases for CREG2 gene to outside databasesPrevious GC identifers: GC02M100417 GC02M101569 GC02M101586 GC02M101423 GC02M101331 GC02M095728 |
Summaries
for CREG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CREG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CREG2 gene promoter:
AhR TBP Pax-5 CUTL1 Tal-1beta AREB6 PPAR-gamma1 Nkx6-1 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CREG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q12.1CREG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M101964: view genomic region
(about GC identifiers)
Start:
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101,964,816 bp from pter |
End:
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102,004,057 bp from pter |
Size:
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39,242 bases |
Orientation:
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minus strand |
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Proteins
for CREG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CREG2_HUMAN, Q8IUH2 (See
protein sequence)Recommended Name: Protein CREG2 precursor Size: 290 amino acids; 32109 Da
Subcellular location: Secreted
Sequence caution: Sequence=BAC04464.1; Type=Erroneous initiation;
Secondary accessions: Q86X03 Q8N540 Q8N9E3Explore the universe of human proteins at neXtProt for CREG2: NX_Q8IUH2
Post-translational modifications:
It is not sure whether N-glycosylation is on Asn-165 and/or Asn-1661
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUH2
CREG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_722578.1
ENSEMBL proteins: ENSP00000315203
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CREG2 for ontologies About GeneDecksing
CREG2 Antibody Products:
Assay Products for CREG2: |
Protein
Domains /
Families
for CREG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CREG2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IUH2ProtoNet protein and cluster: Q8IUH2 UniProtKB/Swiss-Prot: CREG2_HUMAN, Q8IUH2Similarity: Belongs to the CREG family |
Function
for CREG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CREG2 (NM_153836) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010181 | FMN binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
CREG2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CREG2:
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Pathways & Interactions
for CREG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREG2
|
Drugs & Compounds
for CREG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CREG2
Search CenterWatch for drugs/clinical trials and news about CREG2
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Transcripts
for CREG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CREG2 gene: NM_153836.3 Unigene Cluster for CREG2: Cellular repressor of E1A-stimulated genes 2 Hs.732289 [show with all ESTs]Unigene Representative Sequence: NM_1538363 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324768(uc002tba.2) ENST00000495455 ENST00000486966
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CREG2 (NM_153836) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG2 |
Additional cDNA sequence: AB046109.1 AK094970.1 BC032949.2 BC047514.1 5 DOTS entries: DT.40220831 DT.92033270 DT.120957242 DT.92033272 DT.40111133 23 AceView cDNA sequences: BI599413 AW005558 AK094970 BC047514 AB046109 AW135480 CK024221 NM_153836 BC032949 BU619510 H09317 BF966862 BI549204 BF967008 BG706599 H09375 BG678363 BF966119 BG705165 BG036705 BG700682 BF511764 BF818562
GeneLoc Exon Structure
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Expression
for CREG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CREG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAATAAGGC
About this image
See CREG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREG2
SOURCE GeneReport for Unigene cluster: Hs.732289
UniProtKB/Swiss-Prot: CREG2_HUMAN, Q8IUH2Tissue specificity: Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum
SABiosciences Custom PCR Arrays for CREG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CREG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG2 |
Orthologs
for CREG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CREG2 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for CREG2 (if available)
TreeFam Gene Tree for CREG2 (if available) |
Paralogs
for CREG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CREG2 gene
- CREG12
1 SIMAP similar gene for CREG2 using alignment to 3 protein entries: CREG2_HUMAN (see all proteins):CREG1
CREG2 for paralogs About GeneDecksing
|
Genomic Variants
for CREG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CREG2 (101964816 - 102004057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CREG2
2 CNVs: 47994 97922
5 Indels: 42903 40346 26393 45825 61801 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREG2 |
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Disorders
/ Diseases
for CREG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CREG2 for disorders About GeneDecksing
1  disease for CREG2: About MalaCardsfainting
Export disorders for CREG2 gene to outside databases
|
Publications
for CREG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CREG2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CREG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. (PubMed id 12408961)1, 2, 3, 9 Kunita R.... Ikeda J.-E. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CREG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CREG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CREG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CREG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CREG2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CREG2 gene:
Search GeneIP for patents involving CREG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CREG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREG2 | | | OriGene Protein Over-expression Lysate for CREG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CREG2 | | OriGene 3'-UTR Clone for CREG2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CREG2 | | OriGene Custom Protein Services for CREG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG2 |
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 |  |  |  | |
| | | | Search Tocris compounds for CREG2 |
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 | | | CREG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CREG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG2 |
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