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Aliases for CREG2 Gene

Aliases for CREG2 Gene

  • Cellular Repressor Of E1A-Stimulated Genes 2 2 3

External Ids for CREG2 Gene

Summaries for CREG2 Gene

GeneCards Summary for CREG2 Gene

CREG2 (Cellular Repressor Of E1A-Stimulated Genes 2) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and FMN binding. An important paralog of this gene is CREG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREG2 Gene

Genomics for CREG2 Gene

Genomic Location for CREG2 Gene

Start:
101,345,551 bp from pter
End:
101,387,595 bp from pter
Size:
42,045 bases
Orientation:
Minus strand

Genomic View for CREG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREG2 Gene

Regulatory Elements for CREG2 Gene

Proteins for CREG2 Gene

  • Protein details for CREG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUH2-CREG2_HUMAN
    Recommended name:
    Protein CREG2
    Protein Accession:
    Q8IUH2
    Secondary Accessions:
    • Q86X03
    • Q8N540
    • Q8N9E3

    Protein attributes for CREG2 Gene

    Size:
    290 amino acids
    Molecular mass:
    32109 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04464.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CREG2 Gene

Proteomics data for CREG2 Gene at MOPED

Post-translational modifications for CREG2 Gene

Other Protein References for CREG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREG2 Gene

Domains for CREG2 Gene

Protein Domains for CREG2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CREG2_HUMAN
Family:
  • Belongs to the CREG family.:
    • Q8IUH2
genes like me logo Genes that share domains with CREG2: view

No data available for Gene Families for CREG2 Gene

Function for CREG2 Gene

Gene Ontology (GO) - Molecular Function for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CREG2: view

Phenotypes for CREG2 Gene

GenomeRNAi human phenotypes for CREG2:
genes like me logo Genes that share phenotypes with CREG2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CREG2 Gene

Localization for CREG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREG2 Gene COMPARTMENTS Subcellular localization image for CREG2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with CREG2: view

Pathways for CREG2 Gene

SuperPathways for CREG2 Gene

No Data Available

Interacting Proteins for CREG2 Gene

Gene Ontology (GO) - Biological Process for CREG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CREG2: view

No data available for Pathways by source for CREG2 Gene

Transcripts for CREG2 Gene

mRNA/cDNA for CREG2 Gene

Unigene Clusters for CREG2 Gene

Cellular repressor of E1A-stimulated genes 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREG2 Gene

No ASD Table

Relevant External Links for CREG2 Gene

GeneLoc Exon Structure for
CREG2
ECgene alternative splicing isoforms for
CREG2

Expression for CREG2 Gene

mRNA expression in normal human tissues for CREG2 Gene

mRNA differential expression in normal tissues according to GTEx for CREG2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (12.4), Brain - Anterior cingulate cortex (BA24) (11.5), Brain - Cortex (9.6), Brain - Hippocampus (5.8), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CREG2 Gene

SOURCE GeneReport for Unigene cluster for CREG2 Gene Hs.732289

mRNA Expression by UniProt/SwissProt for CREG2 Gene

Q8IUH2-CREG2_HUMAN
Tissue specificity: Brain specific mainly in the limbic system and faintly in the spinal cord but not in cerebellum.
genes like me logo Genes that share expressions with CREG2: view

Orthologs for CREG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CREG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREG2 36
  • 98.85 (n)
  • 97.93 (a)
CREG2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREG2 36
  • 88.39 (n)
  • 84.27 (a)
CREG2 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREG2 36
  • 86.38 (n)
  • 83.49 (a)
CREG2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creg2 36
  • 83.03 (n)
  • 83.27 (a)
Creg2 16
Creg2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREG2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creg2 36
  • 79.39 (n)
  • 78.91 (a)
chicken
(Gallus gallus)
Aves CREG2 36
  • 72.16 (n)
  • 65.92 (a)
CREG2 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREG2 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creg2 36
  • 60.78 (n)
  • 51.88 (a)
zebrafish
(Danio rerio)
Actinopterygii creg2 36
  • 58.27 (n)
  • 50.38 (a)
creg2 37
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CREG 37
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04690 36
  • 51.38 (n)
  • 43.95 (a)
rice
(Oryza sativa)
Liliopsida Os06g0238300 36
  • 50.5 (n)
  • 41.92 (a)
Species with no ortholog for CREG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREG2 Gene

ENSEMBL:
Gene Tree for CREG2 (if available)
TreeFam:
Gene Tree for CREG2 (if available)

Paralogs for CREG2 Gene

Paralogs for CREG2 Gene

Selected SIMAP similar genes for CREG2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CREG2: view

Variants for CREG2 Gene

Sequence variations from dbSNP and Humsavar for CREG2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs871080 -- 101,375,705(-) ACCCC(A/G)TCCTG intron-variant
rs871081 -- 101,375,643(-) GAGTT(C/T)GGAGA intron-variant
rs871901 -- 101,374,918(+) TTGGT(A/G)CACCC intron-variant
rs908127 -- 101,375,763(-) GAGAC(A/G)CAGCC intron-variant
rs960574 -- 101,383,101(-) CCAAT(A/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREG2 Gene

Variant ID Type Subtype PubMed ID
esv34123 CNV Loss 18971310
esv2423576 CNV Deletion 19546169
esv2147665 CNV Deletion 18987734
nsv511800 CNV Loss 21212237
esv4768 CNV Deletion 18987735
esv8755 CNV Loss 19470904
esv2720447 CNV Deletion 23290073
esv1298629 CNV Deletion 17803354

Relevant External Links for CREG2 Gene

HapMap Linkage Disequilibrium report
CREG2

Disorders for CREG2 Gene

Relevant External Links for CREG2

Genetic Association Database (GAD)
CREG2
genes like me logo Genes that share disorders with CREG2: view

No data available for UniProtKB/Swiss-Prot for CREG2 Gene

Publications for CREG2 Gene

  1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. (PMID: 12408961) Kunita R. … Ikeda J.-E. (Genomics 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CREG2 Gene

Sources for CREG2 Gene

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