Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CREG1 Gene

protein-coding   GIFtS: 58
GCID: GC01M167498

Cellular Repressor Of E1A-Stimulated Genes 1

(Previous name: cellular repressor of E1A-stimulated genes)
(Previous symbol: CREG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cellular Repressor Of E1A-Stimulated Genes 11 2 3
CREG1 2 3
Cellular Repressor Of E1A-Stimulated Genes1
Protein CREG12

External Ids:    HGNC: 23511   Entrez Gene: 88042   Ensembl: ENSG000001431627   UniProtKB: O756293   

Export aliases for CREG1 gene to outside databases

Previous GC identifers: GC01M164241 GC01M165776 GC01M138756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CREG1 Gene:
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and
inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular
transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general
transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional
control of cell growth and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREG1 Gene: 
CREG1 (cellular repressor of E1A-stimulated genes 1) is a protein-coding gene. Diseases associated with CREG1 include spondyloarthropathy, and arthropathy. GO annotations related to this gene include oxidoreductase activity and transcription factor binding. An important paralog of this gene is CREG2.

UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes
transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control
activity of cell growth requires interaction with IGF2R

Gene Wiki entry for CREG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREG1 gene promoter:
         GR   Tal-1   p53   Cdc5   E47   FOXL1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CREG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24

CREG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREG1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M167498:  view genomic region     (about GC identifiers)

Start:
167,498,914 bp from pter      End:
167,523,056 bp from pter
Size:
24,143 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629 (See protein sequence)
Recommended Name: Protein CREG1 precursor  
Size: 220 amino acids; 24075 Da
Subunit: Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CREG1:
1XHN (3D)    
Secondary accessions: B2RDD4 Q8N9A3

Explore the universe of human proteins at neXtProt for CREG1: NX_O75629

Explore proteomics data for CREG1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75629

  • CREG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CREG1 Protein Expression
    REFSEQ proteins: NP_003842.1  
    ENSEMBL proteins: 
     ENSP00000359540  

    Human Recombinant Protein Products for CREG1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CREG1 (CREG)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CREG1
    OriGene Protein Over-expression Lysate for CREG1
    OriGene MassSpec for CREG1 
    OriGene Custom Protein Services for CREG1
    GenScript Custom Purified and Recombinant Proteins Services for CREG1
    Novus Biologicals CREG1 Proteins
    Novus Biologicals CREG1 Lysate
    Sino Biological Recombinant Protein for CREG1
    Sino Biological Cell Lysate for CREG1 
    ProSpec Recombinant Protein for CREG1
    Cloud-Clone Corp. Proteins for CREG1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005667transcription factor complex IEA--

    CREG1 for ontologies           About GeneDecksing



    CREG1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CREG1 (CREG)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CREG1
    GenScript Custom Superior Antibodies Services for CREG1
    Novus Biologicals CREG1 Antibodies
    Abcam antibodies for CREG1
    Cloud-Clone Corp. Antibodies for CREG1 
    Search ThermoFisher Antibodies for CREG1
    LSBio Antibodies in human, mouse, rat for CREG1 

    Assay Products for CREG1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CREG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CREG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CREG1 
    Cloud-Clone Corp. CLIAs for CREG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR012349 Split_barrel_FMN-bd
     IPR014631 CREG

    Graphical View of Domain Structure for InterPro Entry O75629

    ProtoNet protein and cluster: O75629

    UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
    Similarity: Belongs to the CREG family


    CREG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREG1_HUMAN, O75629
    Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes
    transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control
    activity of cell growth requires interaction with IGF2R

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9710587
    GO:0008134transcription factor binding IEA--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity IEA--
         
    CREG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CREG1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CREG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CREG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREG1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREG1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidCREG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CREG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CREG1
    Sirion Biotech Customized adenovirus for overexpression of CREG1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CREG1 (see all 8)
    OriGene ORF clones in mouse, rat for CREG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREG1 (NM_003851)
    Sino Biological Human cDNA Clone for CREG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1
    Sirion Biotech Customized lentivirus for stable overexpression of CREG1 
                         Customized lentivirus expression plasmids for stable overexpression of CREG1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CREG1
    Search LifeMap BioReagents cell lines for CREG1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CREG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for CREG1
        Senescence and Autophagy



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CREG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CREG1 (O756293 ENSP000003595404) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    IGF2RP117173, ENSP000003494374I2D: score=2 STRING: ENSP00000349437
    RB1P064003, ENSP000002671634I2D: score=3 STRING: ENSP00000267163
    RBL1P287493, ENSP000003627684I2D: score=3 STRING: ENSP00000362768
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9710587
    GO:0007275multicellular organismal development TAS9710587
    GO:0008283cell proliferation TAS9710587
    GO:0040008regulation of growth IEA--

    CREG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CREG1

    Search CenterWatch for drugs/clinical trials and news about CREG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CREG1 gene: 
    NM_003851.2  

    Unigene Cluster for CREG1:

    Cellular repressor of E1A-stimulated genes 1
    Hs.5710  [show with all ESTs]
    Unigene Representative Sequence: NM_003851
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466652 ENST00000370509(uc001gel.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREG1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidCREG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CREG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG1
    Clone
    Products:
         
    OriGene clones in human, mouse for CREG1 (see all 8)
    OriGene ORF clones in mouse, rat for CREG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREG1 (NM_003851)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1
    Sirion Biotech Customized lentivirus for stable overexpression of CREG1 
                         Customized lentivirus expression plasmids for stable overexpression of CREG1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CREG1
    OriGene qSTAR qPCR primer pairs in human, mouse for CREG1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CREG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG1

    Additional mRNA sequence: 

    AF084523.1 AK075375.1 AK095456.1 AK130006.1 AK315497.1 AY359071.1 BC006786.1 BC008628.1 

    15 DOTS entries:

    DT.91661846  DT.418971  DT.92449927  DT.100794598  DT.101964366  DT.40287278  DT.121358488  DT.100659782 
    DT.100794599  DT.100868546  DT.92449926  DT.95150749  DT.95150840  DT.100794590  DT.100798998 

    24/472 AceView cDNA sequences (see all 472):

    BM907250 BM129327 BE789472 BM907195 Z41676 AY359071 AA040078 AA309845 
    AW518094 AW269516 AA358283 AA565872 AL553423 CR594091 CR622061 CA396041 
    BQ636958 N80212 BU157156 CR616545 BP339858 AL583606 AL550292 AL548803 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CREG1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CREG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CREG1 expression in normal human tissues (normalized intensities)      CREG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCAGAAG
    CREG1 Expression
    About this image


    CREG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived early endothelial progenitor cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Uncategorized (Uncategorized)
             PureStem Progenitor E44

    See CREG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CREG1

    SOURCE GeneReport for Unigene cluster: Hs.5710
        SABiosciences Expression via Pathway-Focused PCR Array including CREG1: 
              Cellular Senescence in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CREG1
    OriGene qSTAR qPCR primer pairs in human, mouse for CREG1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CREG1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CREG1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creg11 , 5 cellular repressor of E1A-stimulated genes 11, 5 80.3(n)1
    76.82(a)1
      1 (73.11 cM)5
    4333751  NM_011804.21  NP_035934.11 
     1657637465 
    chicken
    (Gallus gallus)
    Aves CREG11 cellular repressor of E1A-stimulated genes 1 73.3(n)
    64.52(a)
      768680  XM_003640464.1  XP_003640512.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREG16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    3(163782762-163784628)
    zebrafish
    (Danio rerio)
    Actinopterygii creg11 cellular repressor of E1A-stimulated genes 1 65.67(n)
    58.68(a)
      791208  NM_001080690.1  NP_001074159.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CREG1 Cellular Repressor of E1A-stimulated Genes 47.65(n)
    34.36(a)
      42092  NM_079661.4  NP_524385.2 


    ENSEMBL Gene Tree for CREG1 (if available)
    TreeFam Gene Tree for CREG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CREG1 gene
    CREG22  
    1 SIMAP similar gene for CREG1 using alignment to 1 protein entry:     CREG1_HUMAN:
    CREG2

    CREG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/337 SNPs in CREG1 are shown (see all 337)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910923231,2
    --167509754(+) GGCTGC/TGTAAG 1 -- ds50010--------
    rs1484396891,2
    C--167509755(+) CTGTG-/TTAAGA 1 -- ds50010--------
    rs569947591,2
    C,F--167509800(+) CCTAGT/GGGCTA 1 -- ds50014Minor allele frequency- G:0.27NA CSA EA 244
    rs1449028761,2
    C--167509812(+) CTGGAA/GTATTA 1 -- ds50010--------
    rs1135316011,2
    C--167509857(+) AATCT-/GCAGC 
            
    GCCTG
    1 -- ds50011Minor allele frequency- GCAGC:0.50CSA 2
    rs1821045551,2
    --167509858(+) AATCTC/GCCTGC 1 -- ds50010--------
    rs1490233921,2
    --167509887(+) TTTACC/TCTGTA 1 -- ds50010--------
    rs1457490391,2
    --167509911(+) TTACCC/TGAATG 1 -- ds50010--------
    rs1387513741,2
    --167509921(+) GTCGAC/TATGTA 1 -- ds50010--------
    rs1115978881,2
    F--167509966(+) CTAAGT/GGGGTA 1 -- ds50012Minor allele frequency- G:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for CREG1 (167498914 - 167523056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CREG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819670CNV Loss19587683
    nsv831814CNV Loss17160897
    nsv528710CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CREG1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    10 diseases for CREG1:    About MalaCards
    spondyloarthropathy    arthropathy    spondylitis    ankylosing spondylitis
    essential hypertension    endometrial carcinoma    hypertension    t-cell leukemia
    endotheliitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for CREG1:
    Ankylosing spondylitis

    CREG1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CREG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 58.5 3 10815803 (1), 16344469 (1)

    Genetic Association Database (GAD): CREG1
    Human Genome Epidemiology (HuGE) Navigator: CREG1 (3 documents)

    Export disorders for CREG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CREG1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CREG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PubMed id 9710587)1, 2, 3 Veal E.... Gill G. (1998)
    2. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PubMed id 16344469)1, 2, 9 Sacher M....Cygler M. (2005)
    3. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PubMed id 10815803)1, 2, 9 Veal E.... Gill G. (2000)
    4. Lack of association between cellular repressor of E1A -stimulated genes (GREG) polymorphisms and coronary artery disease in the Han p opulation of North China. (PubMed id 20951690)1, 4 Wang T....Kang J. (2011)
    5. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    6. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8804 HGNC: 2351 AceView: CREG1 Ensembl:ENSG00000143162 euGenes: HUgn8804
    ECgene: CREG1 H-InvDB: CREG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CREG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CREG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CREG1 gene:
    Search GeneIP for patents involving CREG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CREG1 (CREG)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CREG1 (CREG)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CREG1  
     OriGene qPCR primer pairs and template standards for CREG1   OriGene Protein Over-expression Lysate for CREG1  
     OriGene MassSpec something-or-other for CREG1   OriGene clones in human, mouse for CREG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CREG1   OriGene Purified Protein for CREG1  
     OriGene ORF clones in mouse, rat for CREG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CREG1   OriGene Custom Protein Services for CREG1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREG1
     QIAGEN SeqTarget long-range PCR primers for resequencing CREG1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREG1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG1
     GenScript Custom Purified and Recombinant Proteins Services for CREG1 GenScript cDNA clones with any tag delivered in your preferred vector for CREG1
     GenScript Custom Assay Services for CREG1 GenScript Custom Superior Antibodies Services for CREG1
     GenScript Custom overexpressing Cell Line Services for CREG1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CREG1 promoter
     Search Chromatin IP Primers for CREG1
     RT2 qPCR Primer Assay in human, mouse, rat CREG1
     GNC Network for CREG1
     SABiosciences PCR Arrays including human, mouse, rat CREG1
     Search Tocris compounds for CREG1
     Proteins and Antibodies for CREG1
     Cell Lysates for CREG1
     cDNA Clones for CREG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CREG1 antibodies
     CREG1 proteins
     CREG1 lysates
     Antibodies for CREG1
     See all of Abcam's Antibodies, Kits and Proteins for CREG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CREG1




     Proteins for CREG1
     Antibodies for CREG1
     ELISAs for CREG1
     CLIAs for CREG1
     Search LifeMap BioReagents cell lines for CREG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1
     SwitchGear 3'UTR luciferase reporter plasmids for CREG1
     Browse SwitchGear Promoter luciferase reporter plasmids for CREG1
     Search ThermoFisher Antibodies for CREG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CREG1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CREG1
    Customized:
     lentivirus for stable overexpression of CREG1
     lentivirus expression plasmids for stable overexpression of CREG1
     adenovirus for overexpression of CREG1
     LSBio Antibodies in human, mouse, rat for CREG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CREG1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4