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Aliases for CREG1 Gene

Aliases for CREG1 Gene

  • Cellular Repressor Of E1A Stimulated Genes 1 2 3 5
  • CREG 3 4
  • Cellular Repressor Of E1A-Stimulated Genes 1 4
  • Cellular Repressor Of E1A-Stimulated Genes 2
  • Protein CREG1 3

External Ids for CREG1 Gene

Previous HGNC Symbols for CREG1 Gene

  • CREG

Previous GeneCards Identifiers for CREG1 Gene

  • GC01M164241
  • GC01M165776
  • GC01M138756

Summaries for CREG1 Gene

Entrez Gene Summary for CREG1 Gene

  • The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREG1 Gene

CREG1 (Cellular Repressor Of E1A Stimulated Genes 1) is a Protein Coding gene. Among its related pathways are Immune System and Senescence and Autophagy. GO annotations related to this gene include oxidoreductase activity and transcription corepressor activity. An important paralog of this gene is CREG2.

UniProtKB/Swiss-Prot for CREG1 Gene

  • May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Gene Wiki entry for CREG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREG1 Gene

Genomics for CREG1 Gene

Regulatory Elements for CREG1 Gene

Enhancers for CREG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F167547 1.4 FANTOM5 ENCODE 20.3 +3.9 3922 4.2 PKNOX1 ATF1 ARNT ZNF766 ELK1 GATA2 JUNB REST KAT8 CREB3 CREG1 AKR1D1P1
GH01F167555 1.3 Ensembl ENCODE 16.8 -2.2 -2203 1.2 PKNOX1 ATF1 MLX CREB3L1 ARID4B DMAP1 YY1 GTF3C2 ZNF143 MXD4 CREG1 DUTP6 RPS18P4
GH01F167552 1.1 ENCODE 17.9 +0.3 259 2.5 ATF1 PKNOX1 CREB3L1 SIN3A YY1 GLIS2 GATA2 ZNF207 ZNF143 SP3 CREG1 MPZL1 DUTP6 AKR1D1P1
GH01F167445 1.7 FANTOM5 Ensembl ENCODE 11.1 +101.6 101588 13.8 PKNOX1 ATF1 SIN3A FEZF1 GLI4 ZNF2 ZNF766 GLIS2 GATA2 ZNF263 CD247 CNN2P10 FMO11P ENSG00000225325 FMO10P LOC441914 AKR1D1P1 CREG1 GPA33 ENSG00000273160
GH01F167713 1.8 FANTOM5 Ensembl ENCODE 10 -161.7 -161682 4.6 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZFP41 TIPRL MPZL1 LOC441914 FMO11P CNN2P10 DUTP6 CREG1 TADA1 POU2F1 TRP-CGG1-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CREG1 on UCSC Golden Path with GeneCards custom track

Promoters for CREG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000671415 319 2201 ATF1 PKNOX1 CREB3L1 SIN3A YY1 GATA2 ZNF207 ZNF143 SP3 GTF2B

Genomic Location for CREG1 Gene

Chromosome:
1
Start:
167,529,677 bp from pter
End:
167,553,819 bp from pter
Size:
24,143 bases
Orientation:
Minus strand

Genomic View for CREG1 Gene

Genes around CREG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREG1 Gene

Proteins for CREG1 Gene

  • Protein details for CREG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75629-CREG1_HUMAN
    Recommended name:
    Protein CREG1
    Protein Accession:
    O75629
    Secondary Accessions:
    • B2RDD4
    • Q8N9A3

    Protein attributes for CREG1 Gene

    Size:
    220 amino acids
    Molecular mass:
    24075 Da
    Quaternary structure:
    • Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.

    Three dimensional structures from OCA and Proteopedia for CREG1 Gene

neXtProt entry for CREG1 Gene

Post-translational modifications for CREG1 Gene

Other Protein References for CREG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CREG1
  • Cloud-Clone Corp. Antibodies for CREG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CREG1

No data available for DME Specific Peptides for CREG1 Gene

Domains & Families for CREG1 Gene

Protein Domains for CREG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75629

UniProtKB/Swiss-Prot:

CREG1_HUMAN :
  • Belongs to the CREG family.
Family:
  • Belongs to the CREG family.
genes like me logo Genes that share domains with CREG1: view

No data available for Gene Families for CREG1 Gene

Function for CREG1 Gene

Molecular function for CREG1 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Gene Ontology (GO) - Molecular Function for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 9710587
GO:0008134 transcription factor binding IEA --
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CREG1: view
genes like me logo Genes that share phenotypes with CREG1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREG1 Gene

Localization for CREG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CREG1 gene
Compartment Confidence
extracellular 5
lysosome 5
mitochondrion 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 25645918
GO:0005667 transcription factor complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CREG1: view

Pathways & Interactions for CREG1 Gene

genes like me logo Genes that share pathways with CREG1: view

Pathways by source for CREG1 Gene

1 BioSystems pathway for CREG1 Gene
2 Reactome pathways for CREG1 Gene

Gene Ontology (GO) - Biological Process for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9710587
GO:0007275 multicellular organism development TAS 9710587
GO:0008283 cell proliferation TAS 9710587
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with CREG1: view

No data available for SIGNOR curated interactions for CREG1 Gene

Transcripts for CREG1 Gene

mRNA/cDNA for CREG1 Gene

Unigene Clusters for CREG1 Gene

Cellular repressor of E1A-stimulated genes 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CREG1 Gene

GeneLoc Exon Structure for
CREG1
ECgene alternative splicing isoforms for
CREG1

Expression for CREG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CREG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CREG1 Gene

This gene is overexpressed in Heart (15.7), Vitreous humor (9.2), and Spleen (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CREG1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CREG1 Gene:

CREG1

SOURCE GeneReport for Unigene cluster for CREG1 Gene:

Hs.5710
genes like me logo Genes that share expression patterns with CREG1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CREG1 Gene

Orthologs for CREG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREG1 34 35
  • 98.62 (n)
dog
(Canis familiaris)
Mammalia CREG1 34 35
  • 88.21 (n)
cow
(Bos Taurus)
Mammalia CREG1 34 35
  • 85.76 (n)
mouse
(Mus musculus)
Mammalia Creg1 34 16 35
  • 82.05 (n)
rat
(Rattus norvegicus)
Mammalia Creg1 34
  • 81.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CREG1 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREG1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CREG1 34 35
  • 74.56 (n)
lizard
(Anolis carolinensis)
Reptilia CREG1 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creg1 34
  • 67.06 (n)
zebrafish
(Danio rerio)
Actinopterygii creg1 34 35
  • 65.67 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5415 34
fruit fly
(Drosophila melanogaster)
Insecta CREG 34 35
  • 47.65 (n)
Species where no ortholog for CREG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREG1 Gene

ENSEMBL:
Gene Tree for CREG1 (if available)
TreeFam:
Gene Tree for CREG1 (if available)

Paralogs for CREG1 Gene

Paralogs for CREG1 Gene

(1) SIMAP similar genes for CREG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CREG1: view

Variants for CREG1 Gene

Sequence variations from dbSNP and Humsavar for CREG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1005299 -- 167,555,562(-) cactg(C/T)tggtg upstream-variant-2KB
rs10405 -- 167,541,302(-) AACAT(G/T)GCATT upstream-variant-2KB, utr-variant-3-prime
rs1043310 -- 167,541,798(-) AGATA(C/G)ACAAA upstream-variant-2KB, utr-variant-3-prime
rs10449257 -- 167,550,134(+) acggt(C/T)gtaca intron-variant
rs10918711 -- 167,545,895(+) ATTTT(C/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREG1 Gene

Variant ID Type Subtype PubMed ID
nsv831814 CNV loss 17160897
nsv819670 CNV loss 19587683
nsv528710 CNV gain 19592680
nsv1078878 OTHER inversion 25765185

Variation tolerance for CREG1 Gene

Gene Damage Index Score: 0.51; 11.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREG1 Gene

Disorders for CREG1 Gene

Relevant External Links for CREG1

Genetic Association Database (GAD)
CREG1
Human Genome Epidemiology (HuGE) Navigator
CREG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREG1

No disorders were found for CREG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREG1 Gene

Publications for CREG1 Gene

  1. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PMID: 16344469) Sacher M. … Cygler M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
  2. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PMID: 10815803) Veal E. … Gill G. (Oncogene 2000) 3 4 22 64
  3. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PMID: 9710587) Veal E. … Gill G. (Mol. Cell. Biol. 1998) 2 3 4 64
  4. Lack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China. (PMID: 20951690) Wang T. … Kang J. (Clin. Chim. Acta 2011) 3 46 64
  5. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. (PMID: 20060003) Han Y. … Yan C. (J. Mol. Cell. Cardiol. 2010) 3 22 64

Products for CREG1 Gene

Sources for CREG1 Gene

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