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CREG1 Gene

protein-coding   GIFtS: 58
GCID: GC01M167498

Cellular Repressor Of E1A-Stimulated Genes 1

(Previous name: cellular repressor of E1A-stimulated genes)
(Previous symbol: CREG)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cellular Repressor Of E1A-Stimulated Genes 11 2 3
CREG1 2 3
Cellular Repressor Of E1A-Stimulated Genes1
Protein CREG12

External Ids:    HGNC: 23511   Entrez Gene: 88042   Ensembl: ENSG000001431627   UniProtKB: O756293   

Export aliases for CREG1 gene to outside databases

Previous GC identifers: GC01M164241 GC01M165776 GC01M138756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREG1 Gene:
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and
inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular
transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general
transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional
control of cell growth and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREG1 Gene:
CREG1 (cellular repressor of E1A-stimulated genes 1) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and transcription factor binding. An important paralog of this gene is CREG2.

UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes
transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control
activity of cell growth requires interaction with IGF2R

Gene Wiki entry for CREG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREG1 gene promoter:
         GR   Tal-1   p53   Cdc5   E47   FOXL1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CREG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24

CREG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREG1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M167498:  view genomic region     (about GC identifiers)

Start:
167,498,914 bp from pter      End:
167,523,056 bp from pter
Size:
24,143 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629 (See protein sequence)
Recommended Name: Protein CREG1 precursor  
Size: 220 amino acids; 24075 Da
Subunit: Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation
1 PDB 3D structure from and Proteopedia for CREG1:
1XHN (3D)    
Secondary accessions: B2RDD4 Q8N9A3

Explore the universe of human proteins at neXtProt for CREG1: NX_O75629

Explore proteomics data for CREG1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn160, Asn193, Asn216

  • See CREG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003842.1  
    ENSEMBL proteins: 
     ENSP00000359540  

    CREG1 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for CREG1
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    Cloud-Clone Corp. Proteins for CREG1

     
    Search eBioscience for Proteins for CREG1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012349 Split_barrel_FMN-bd
     IPR014631 CREG

    Graphical View of Domain Structure for InterPro Entry O75629

    ProtoNet protein and cluster: O75629

    UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
    Similarity: Belongs to the CREG family


    Find genes that share domains with CREG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREG1_HUMAN, O75629
    Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes
    transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control
    activity of cell growth requires interaction with IGF2R

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9710587
    GO:0008134transcription factor binding IEA--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity IEA--
         
    Find genes that share ontologies with CREG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CREG1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREG1

    miRNA
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    miRTarBase miRNAs that target CREG1:
    hsa-mir-31-5p (MIRT007367), hsa-mir-941 (MIRT036577), hsa-mir-26b-5p (MIRT028971)

    Block miRNA regulation of human, mouse, rat CREG1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidCREG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREG1

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    Sino Biological Human cDNA Clone for CREG1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREG1_HUMAN, O75629: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    nucleus2
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with CREG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for CREG1
        Senescence and Autophagy



        Pathway & Disease-focused RT2 Profiler PCR Array including CREG1: 
              Cellular Senescence in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CREG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CREG1 (O756293 ENSP000003595404) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    IGF2RP117173, ENSP000003494374I2D: score=2 STRING: ENSP00000349437
    RB1P064003, ENSP000002671634I2D: score=3 STRING: ENSP00000267163
    RBL1P287493, ENSP000003627684I2D: score=3 STRING: ENSP00000362768
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9710587
    GO:0007275multicellular organismal development TAS9710587
    GO:0008283cell proliferation TAS9710587
    GO:0040008regulation of growth IEA--

    Find genes that share ontologies with CREG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CREG1 gene: 
    NM_003851.2  

    Unigene Cluster for CREG1:

    Cellular repressor of E1A-stimulated genes 1
    Hs.5710  [show with all ESTs]
    Unigene Representative Sequence: NM_003851
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466652 ENST00000370509(uc001gel.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidCREG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREG1
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    GenScript: all cDNA clones in your preferred vector: CREG1 (NM_003851)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1
    Primer
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    OriGene qPCR primer pairs and template standards for CREG1
    OriGene qSTAR qPCR primer pairs in human, mouse for CREG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREG1
      QuantiTect SYBR Green Assays in human, mouse, rat CREG1
      QuantiFast Probe-based Assays in human, mouse, rat CREG1

    Additional mRNA sequence: 

    AF084523.1 AK075375.1 AK095456.1 AK130006.1 AK315497.1 AY359071.1 BC006786.1 BC008628.1 

    15 DOTS entries:

    DT.91661846  DT.418971  DT.92449927  DT.100794598  DT.101964366  DT.40287278  DT.121358488  DT.100659782 
    DT.100794599  DT.100868546  DT.92449926  DT.95150749  DT.95150840  DT.100794590  DT.100798998 

    Selected AceView cDNA sequences (see all 472):

    CA310744 AW269516 BM052844 CA306138 CR611446 BG260615 CR616545 CR594091 
    BE896752 AA358777 AA448159 BQ898145 AL553423 CA438536 CK819582 T16622 
    AY359071 AA894714 BQ636958 AL583606 AV711169 BM992801 AA309845 AW518094 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CREG1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CREG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCAGAAG
    CREG1 Expression
    About this image


    CREG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    CREG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5710
        Pathway & Disease-focused RT2 Profiler PCR Array including CREG1: 
              Cellular Senescence in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREG1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creg11 , 5 cellular repressor of E1A-stimulated genes 11, 5 82.05(n)1
    78.97(a)1
      1 (73.11 cM)5
    4333751  NM_011804.21  NP_035934.11 
     1657637465 
    chicken
    (Gallus gallus)
    Aves CREG11 cellular repressor of E1A-stimulated genes 1 74.56(n)
    64.5(a)
      768680  XM_003640464.2  XP_003640512.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREG16
    cellular repressor of E1A-stimulated genes 1
    59(a)
    1 ↔ 1
    3(163782762-163784628)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia creg11 cellular repressor of E1A-stimulated genes 1 67.06(n)
    66.86(a)
      734028  XM_002936231.2  XP_002936277.2 
    zebrafish
    (Danio rerio)
    Actinopterygii creg11 cellular repressor of E1A-stimulated genes 1 65.67(n)
    58.68(a)
      791208  NM_001080690.1  NP_001074159.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CREG1 Cellular Repressor of E1A-stimulated Genes 47.65(n)
    34.36(a)
      42092  NM_079661.5  NP_524385.2 


    ENSEMBL Gene Tree for CREG1 (if available)
    TreeFam Gene Tree for CREG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREG1 gene
    CREG22  
    1 SIMAP similar gene for CREG1 using alignment to 1 protein entry:     CREG1_HUMAN:
    CREG2

    Find genes that share paralogs with CREG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREG1 (see all 337)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910923231,2
    --167509754(+) GGCTGC/TGTAAG 1 -- ds50010--------
    rs1484396891,2
    C--167509755(+) CTGTG-/TTAAGA 1 -- ds50010--------
    rs569947591,2
    C,F--167509800(+) CCTAGT/GGGCTA 1 -- ds50014Minor allele frequency- G:0.27NA CSA EA 244
    rs1449028761,2
    C--167509812(+) CTGGAA/GTATTA 1 -- ds50010--------
    rs1135316011,2
    C--167509857(+) AATCT-/GCAGC 
            
    GCCTG
    1 -- ds50011Minor allele frequency- GCAGC:0.50CSA 2
    rs1821045551,2
    --167509858(+) AATCTC/GCCTGC 1 -- ds50010--------
    rs1490233921,2
    --167509887(+) TTTACC/TCTGTA 1 -- ds50010--------
    rs1457490391,2
    --167509911(+) TTACCC/TGAATG 1 -- ds50010--------
    rs1387513741,2
    --167509921(+) GTCGAC/TATGTA 1 -- ds50010--------
    rs1115978881,2
    F--167509966(+) CTAAGT/GGGGTA 1 -- ds50012Minor allele frequency- G:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for CREG1 (167498914 - 167523056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CREG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819670CNV Loss19587683
    nsv831814CNV Loss17160897
    nsv528710CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREG1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for CREG1:
    Ankylosing spondylitis

    Find genes that share disorders with CREG1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CREG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 58.5 3 10815803 (1), 16344469 (1)

    Genetic Association Database (GAD): CREG1
    Human Genome Epidemiology (HuGE) Navigator: CREG1 (3 documents)

    Export disorders for CREG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREG1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CREG1)
        Utopia: connect your pdf to the dynamic
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    1. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PubMed id 9710587)1, 2, 3 Veal E.... Gill G. (Mol. Cell. Biol. 1998)
    2. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PubMed id 16344469)1, 2, 9 Sacher M....Cygler M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    3. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PubMed id 10815803)1, 2, 9 Veal E.... Gill G. (Oncogene 2000)
    4. Lack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China. (PubMed id 20951690)1, 4 Wang T....Kang J. ( international journal of clinical chemistry 2011)
    5. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    6. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8804 HGNC: 2351 AceView: CREG1 Ensembl:ENSG00000143162 euGenes: HUgn8804
    ECgene: CREG1 H-InvDB: CREG1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CREG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREG1 gene:
    Search GeneIP for patents involving CREG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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