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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CREG1 Gene

protein-coding   GIFtS: 55
GCID: GC01M167498

cellular repressor of E1A-stimulated genes 1

(Previous name: cellular repressor of E1A-stimulated genes )
(Previous symbol: CREG)
 Explore 13 diseases affiliated with
CREG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CREG1    

Aliases
for CREG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cellular Repressor Of E1A-Stimulated Genes 11 2 3
CREG1 2 3
Cellular Repressor Of E1A-Stimulated Genes1
Protein CREG12

External Ids:    HGNC: 23511   Entrez Gene: 88042   Ensembl: ENSG000001431627   UniProtKB: O756293   

Export aliases for CREG1 gene to outside databases

Previous GC identifers: GC01M164241 GC01M165776 GC01M138756


Summaries
for CREG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CREG1:
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit
differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation
by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP
and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and
differentiation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional
activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell
growth requires interaction with IGF2R

Gene Wiki entry for CREG1


Genomic Views
for CREG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREG1 gene promoter:
         GR   Tal-1   p53   Cdc5   E47   FOXL1   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CREG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24

CREG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREG1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M167498:  view genomic region     (about GC identifiers)

Start:
 167,498,914 bp from pter      End:
 167,523,056 bp from pter
Size:
 24,143 bases      Orientation:
 minus strand

Proteins
for CREG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629 (See protein sequence)
Recommended Name: Protein CREG1 precursor  
Size: 220 amino acids; 24075 Da
Subunit: Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CREG1:
1XHN (3D)    
Secondary accessions: B2RDD4 Q8N9A3

Explore the universe of human proteins at neXtProt for CREG1: NX_O75629

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75629

    • CREG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003842.1  
    ENSEMBL proteins: 
     ENSP00000359540  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CREG1 (CREG)
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    OriGene Purified Protein: CREG1
    OriGene Protein Over-expression Lysate: CREG1
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    Novus Biologicals CREG1 Protein
    Novus Biologicals CREG1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CREG1
    Uscn Proteins for CREG1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005667transcription factor complex IEA--


    CREG1 for ontologies           About GeneDecksing



    CREG1 Antibody Products: 
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    Uscn Antibodies for CREG1
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    Assay Products for CREG1: 
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    Uscn ELISAs and CLIAs for CREG1

    Protein Domains /
    Families
    for CREG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CREG1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012349 Split_barrel_FMN-bd
     IPR014631 CREG

    Graphical View of Domain Structure for InterPro Entry O75629

    ProtoNet protein and cluster: O75629

    UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
    Similarity: Belongs to the CREG family


    Function
    for CREG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CREG1_HUMAN, O75629
    Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional
    activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell
    growth requires interaction with IGF2R

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREG1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: CREG1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREG1 (see all 7)
    OriGene shRNA RFP: CREG1
    OriGene siRNA: CREG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CREG1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREG1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: CREG1 (NM_003851)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREG1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CREG1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity TAS9710587
    GO:0008134transcription factor binding IEA--
    GO:0010181FMN binding IEA--
    GO:0016491oxidoreductase activity IEA--


    CREG1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CREG1:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for CREG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Senescence and Autophagy
    		Senescence and Autophagy1.00


    1 BioSystems Pathway for CREG1 
        Senescence and Autophagy


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CREG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CREG1 (O756293 ENSP000003595404) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    TBPP202263, ENSP000002303544I2D: score=2 STRING: ENSP00000230354
    IGF2RP117173, ENSP000003494374I2D: score=2 STRING: ENSP00000349437
    RB1P064003, ENSP000002671634I2D: score=3 STRING: ENSP00000267163
    RBL1P287493, ENSP000003627684I2D: score=3 STRING: ENSP00000362768
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9710587
    GO:0007275multicellular organismal development TAS9710587
    GO:0008283cell proliferation TAS9710587
    GO:0040008regulation of growth IEA--


    CREG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CREG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CREG1
    Search CenterWatch for drugs/clinical trials and news about CREG1 

    Transcripts
    for CREG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CREG1 gene: 
    NM_003851.2  

    Unigene Cluster for CREG1:

    Cellular repressor of E1A-stimulated genes 1
    Hs.5710  [show with all ESTs]
    Unigene Representative Sequence: NM_003851
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466652 ENST00000370509(uc001gel.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREG1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CREG1:
    hsa-miR-1287 hsa-miR-31 hsa-miR-182 hsa-miR-135b hsa-miR-944 hsa-miR-450b-5p hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: CREG1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREG1 (see all 7)
    OriGene shRNA RFP: CREG1
    OriGene siRNA: CREG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREG1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREG1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREG1 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: CREG1 (NM_003851)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CREG1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREG1

    Additional cDNA sequence: 

    AF084523.1 AK075375.1 AK095456.1 AK130006.1 AK315497.1 AY359071.1 BC006786.1 BC008628.1 

    15 DOTS entries:

    DT.91661846  DT.418971  DT.92449927  DT.100794598  DT.101964366  DT.40287278  DT.121358488  DT.100659782 
    DT.100794599  DT.100868546  DT.92449926  DT.95150749  DT.95150840  DT.100794590  DT.100798998 

    24/472 AceView cDNA sequences (see all 472):

    CA306138 BF195754 AI954898 AI886778 BM907250 AA358283 AW189709 AL553403 
    AA991372 BP341696 AI350290 BM791474 AI753085 AA306776 CR623745 AA907490 
    CR611446 AI093079 AV708274 AV711169 BQ015239 BM845175 AI200972 AA946583 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CREG1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for CREG1

    Expression
    for CREG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CREG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTCAGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CREG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CREG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CREG1

    SOURCE GeneReport for Unigene cluster: Hs.5710
        SABiosciences Expression via Pathway-Focused PCR Array including CREG1: 
              Cellular Senescence in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREG1

    Orthologs
    for CREG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CREG1 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Creg11 , 5 cellular repressor of E1A-stimulated genes 11, 5 80.3(n)1
    76.82(a)1    		   1 (73.11 cM)5
    4333751  NM_011804.21  NP_035934.11 
     1657637465 
    chicken
    (Gallus gallus)    		 Aves CREG11 cellular repressor of E1A-stimulated genes 1 73.3(n)
    64.52(a)    		   768680  XM_003640464.1  XP_003640512.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CREG16
    		 --
    		 58(a)
    		 1 ↔ 1
    		 3(163782762-163784628)
    zebrafish
    (Danio rerio)    		 Actinopterygii creg11 cellular repressor of E1A-stimulated genes 1 65.67(n)
    58.68(a)    		   791208  NM_001080690.1  NP_001074159.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CREG1 Cellular Repressor of E1A-stimulated Genes 47.65(n)
    34.36(a)    		   42092  NM_079661.4  NP_524385.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G046906
    		 Pyridoxamine 5'-phosphate oxidase family protein
    		 30(a)
    		 1 → many
    		 2(1644497-1646355)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 CREG1 precursor, putative, expressed
    		 31(a)
    		 1 → many
    		 6(7187390-7190452)


    ENSEMBL Gene Tree for CREG1 (if available)
    TreeFam Gene Tree for CREG1 (if available) 

    Paralogs
    for CREG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CREG1 gene
    CREG22  
    1 SIMAP similar gene for CREG1 using alignment to 1 protein entry:     CREG1_HUMAN:
    CREG2

    CREG1 for paralogs           About GeneDecksing



    Genomic Variants
    for CREG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 NCBI SNPs in CREG1 are shown (see all 265)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1484396891,2
    		C,--167509754(+) CTGTG-/TTAAGA 1 -- ds50010--------
    rs1910923231,2
    		--167509754(+) GGCTGC/TGTAAG 1 -- ds50010--------
    rs569947591,2
    		C,F,--167509800(+) CCTAGT/GGGCTA 1 -- ds50014Minor allele frequency- G:0.27NA CSA EA 244
    rs1449028761,2
    		--167509812(+) CTGGAA/GTATTA 1 -- ds50010--------
    rs1135316011,2
    		C,--167509857(+) AATCT-/GCAGC 
                GCCTG     		1 -- ds50011Minor allele frequency- GCAGC:0.50CSA 2
    rs1821045551,2
    		--167509858(+) AATCTC/GCCTGC 1 -- ds50010--------
    rs1490233921,2
    		--167509887(+) TTTACC/TCTGTA 1 -- ds50010--------
    rs1457490391,2
    		--167509911(+) TTACCC/TGAATG 1 -- ds50010--------
    rs1387513741,2
    		--167509921(+) GTCGAC/TATGTA 1 -- ds50010--------
    rs1115978881,2
    		--167509966(+) CTAAGT/GGGGTA 1 -- ds50012Minor allele frequency- G:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for CREG1 (167498914 - 167523056 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CREG1
         1 Indel: 58344

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREG1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREG1

    Disorders / Diseases
    for CREG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CREG1 for disorders           About GeneDecksing

    13 diseases for CREG1:    About MalaCards
    ankylosing spondylitis    spondylitis    essential hypertension    spondyloarthropathy
    arthropathy    embryonal carcinoma    endometrial carcinoma    hypertension
    t-cell leukemia    carcinoma    fibrosis    leukemia
    arthritis

    1 Novoseek disease relationship for CREG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 58.5 3 10815803 (1), 16344469 (1)

    Human Genome Epidemiology (HuGE) Navigator: CREG1 (3 documents)

    Export disorders for CREG1 gene to outside databases

    Publications
    for CREG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CREG1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CREG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PubMed id 9710587)1, 2, 3 Veal E.... Gill G. (1998)
    2. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PubMed id 16344469)1, 2, 9 Sacher M....Cygler M. (2005)
    3. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PubMed id 10815803)1, 2, 9 Veal E.... Gill G. (2000)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor. (PubMed id 12934103)1, 2 Di Bacco A. and Gill G. (2003)
    10. Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis. (PubMed id 19413895)1, 9 Bian Z....Li H. (2009)

    External Searches for CREG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CREG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8804 HGNC: 2351 AceView: CREG1 Ensembl:ENSG00000143162 euGenes: HUgn8804
    ECgene: CREG1 H-InvDB: CREG1

    Other Databases showing CREG1 gene

    (According to HUGE)
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    Specialized Databases showing CREG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CREG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CREG1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CREG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for CREG1 gene:
    Search GeneIP for patents involving CREG1

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