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CREBZF Gene

protein-coding   GIFtS: 48
GCID: GC11M085368

CREB/ATF BZIP Transcription Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CREB/ATF BZIP Transcription Factor1 2     HCF-Binding Transcription Factor Zhangfei2 3
Zhangfei1 2     SMILE2
Host Cell Factor-Binding Transcription Factor Zhangfei2 3     SHP-Interacting Leucine Zipper Protein2
ZF2 3     

External Ids:    HGNC: 249051   Entrez Gene: 584872   Ensembl: ENSG000001375047   OMIM: 6064445   UniProtKB: Q9NS373   

Export aliases for CREBZF gene to outside databases

Previous GC identifers: GC11M085046 GC11M081665


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CREBZF Gene:
CREBZF (CREB/ATF bZIP transcription factor) is a protein-coding gene. Diseases associated with CREBZF include herpes simplex, and medulloblastoma. GO annotations related to this gene include identical protein binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37
Function: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells
infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional
activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some
cellular genes in CREBZF-expressing cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREBZF gene promoter:
         PPAR-gamma1   S8   ATF-2   POU3F2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CREBZF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREBZF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

CREBZF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREBZF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M085368:  view genomic region     (about GC identifiers)

Start:
85,368,608 bp from pter      End:
85,393,951 bp from pter
Size:
25,344 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37 (See protein sequence)
Recommended Name: CREB/ATF bZIP transcription factor  
Size: 354 amino acids; 37134 Da
Subunit: Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity
Miscellaneous: Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD
Sequence caution: Sequence=AAD28325.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD28325.1; Type=Frameshift; Positions=5, 49; Sequence=AAZ42189.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG36256.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAG36256.1; Type=Frameshift; Positions=59;
Secondary accessions: B2R8Q9 Q0P5U9 Q52LT3

Explore the universe of human proteins at neXtProt for CREBZF: NX_Q9NS37

Explore proteomics data for CREBZF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys184
  • Modification sites at PhosphoSitePlus

  • See CREBZF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001034707.1  
    ENSEMBL proteins: 
     ENSP00000434281   ENSP00000260058   ENSP00000435980   ENSP00000433380   ENSP00000435762  
     ENSP00000433459   ENSP00000381342  

    CREBZF Human Recombinant Protein Products:

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    Novus Biologicals CREBZF Proteins
    Novus Biologicals CREBZF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CREBZF

    CREBZF Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q9NS37

    ProtoNet protein and cluster: Q9NS37

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREBZF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZHANG_HUMAN, Q9NS37
    Function: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells
    infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional
    activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some
    cellular genes in CREBZF-expressing cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10871379
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10871379
    GO:0042802identical protein binding IPI16343488
    GO:0043565sequence-specific DNA binding IEA--
         
    CREBZF for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREBZF
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREBZF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREBZF

    miRNA
    Products:
        
    miRTarBase miRNAs that target CREBZF:
    hsa-mir-26b-5p (MIRT029389), hsa-mir-192-5p (MIRT026395), hsa-mir-340-5p (MIRT019586), hsa-mir-221-3p (MIRT003363), hsa-mir-215-5p (MIRT024367), hsa-mir-421 (MIRT016120)

    Block miRNA regulation of human, mouse, rat CREBZF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREBZF (see all 236):
    hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-4275 hsa-miR-409-5p hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREBZF

    Gene Editing
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    Sino Biological Human cDNA Clone for CREBZF
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBZF

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBZF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZHANG_HUMAN, Q9NS37: Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with
    CREB3 and HCFC1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15705566

    CREBZF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREBZF
    Interactions:

        GeneGlobe Interaction Network for CREBZF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CREBZF (Q9NS371, 2, 3 ENSP000002600584) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516101, 3, ENSP000003095554EBI-632965,EBI-396176 I2D: score=4 STRING: ENSP00000309555
    CREBZFQ9NS371, 2EBI-632965,EBI-632965 MINT-77962 MINT-77963
    ZNF512BQ96KM62, 3MINT-60790 I2D: score=2 
    ATF4P188481, 2, 3, ENSP000003367904EBI-632965,EBI-492498 MINT-73538 MINT-73537 MINT-73540 MINT-73535 MINT-73539 I2D: score=2 STRING: ENSP00000336790
    CREB3O438893, ENSP000003421364I2D: score=2 STRING: ENSP00000342136
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IDA10871379
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0009615response to virus IDA10871379
    GO:0045814negative regulation of gene expression, epigenetic IEP15705566
    GO:0045892negative regulation of transcription, DNA-templated IMP15705566

    CREBZF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREBZF (ZHANG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CREBZF gene (2 alternative transcripts): 
    NM_021212.1  NM_001039618.2  

    Unigene Cluster for CREBZF:

    CREB/ATF bZIP transcription factor
    Hs.535319  [show with all ESTs]
    Unigene Representative Sequence: NM_001039618
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490820(uc010rtc.1 uc010rtd.1) ENST00000528561 ENST00000260058
    ENST00000531515 ENST00000534224 ENST00000527529 ENST00000525639 ENST00000527447(uc001pas.2)
    ENST00000528889 ENST00000398294
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CREBZF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREBZF (see all 236):
    hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-4275 hsa-miR-409-5p hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CREBZF
    Predesigned siRNA for gene silencing in human, mouse, rat CREBZF
    Clone
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    OriGene ORF clones in mouse, rat for CREBZF
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    GenScript: all cDNA clones in your preferred vector: CREBZF (NM_001039618)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBZF
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREBZF
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      QuantiFast Probe-based Assays in human, mouse, rat CREBZF

    Additional mRNA sequence: 

    AF039942.1 AK313471.1 AL110236.1 BC060807.1 BC093796.1 BC093798.1 DQ128105.1 NR_028024.1 
    NR_028025.1 NR_028026.1 NR_028027.1 

    14 DOTS entries:

    DT.99948953  DT.113518  DT.102830357  DT.91764277  DT.120719112  DT.100730999  DT.95212322  DT.100787984 
    DT.91978464  DT.100711616  DT.120719127  DT.120729870  DT.91764283  DT.95339610 

    Selected AceView cDNA sequences (see all 458):

    BM725415 AA651898 AA404580 BF115651 BQ695329 AW954133 BQ006460 D61501 
    BQ022305 CA867608 AV708631 BE696875 AI493996 BU625631 BF593892 BE924965 
    AI351382 AA767270 AI554925 AA649003 N50895 AW183422 BE696852 AI634541 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREBZF expression in normal human tissues (normalized intensities)      CREBZF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGCTAATT
    CREBZF Expression
    About this image


    CREBZF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Uterus (Reproductive System)
     
     Spleen (Hematopoietic System)
    CREBZF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREBZF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535319

    UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37
    Tissue specificity: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant
    in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and
    very low amounts in heart, lung and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBZF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CREBZF gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crebzf1 , 5 CREB/ATF bZIP transcription factor1, 5 86.7(n)1
    83.76(a)1
      7 (50.59 cM)5
    2334901  NM_145151.31  NP_660133.21 
     904427295 
    lizard
    (Anolis carolinensis)
    Reptilia CREBZF6
    CREB/ATF bZIP transcription factor
    58(a)
    1 ↔ 1
    3(200663790-200664341)
    zebrafish
    (Danio rerio)
    Actinopterygii crebzf6
    CREB/ATF bZIP transcription factor
    42(a)
    1 ↔ 1
    10(30006394-30009344) ENSDARG00000089787


    ENSEMBL Gene Tree for CREBZF (if available)
    TreeFam Gene Tree for CREBZF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREBZF (see all 180)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559458051,2
    C,F--85368127(+) TTAGAA/TTCACA 5 -- ds50012Minor allele frequency- T:0.07NA EA 240
    rs1908588541,2
    --85368140(+) ATTAAC/GTAATC 5 -- ds50010--------
    rs1839621091,2
    --85368352(+) AGCCAC/GTAGCC 5 -- ds50010--------
    rs1403654661,2
    --85368357(+) CTAGCC/TTATGT 5 -- ds50010--------
    rs1865372731,2
    --85368520(+) AAAAGA/TACCAA 5 -- ds50010--------
    rs1905954981,2
    C--85368539(+) TTAAGA/TGGCAT 5 -- ds50010--------
    rs1503818361,2
    --85368577(+) ATTACC/TTCCAA 5 -- ds50010--------
    rs1831961721,2
    --85368711(+) GATGAA/GAAACT 5 -- ut31 nc-transcript-variant0--------
    rs803181601,2
    C,F--85368745(+) TCTCAA/GTTTTT 5 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.05WA 118
    rs1448690191,2
    C--85368764(+) AAAGAC/TGATTT 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CREBZF (85368608 - 85393951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CREBZF:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1246n71CNV Loss21882294
    essv22464CNV CNV17122850
    esv678CNV CNV17122850
    essv7704CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606444    OMIM disorders: --

    5 diseases for CREBZF:    About MalaCards
    herpes simplex    medulloblastoma    cerebritis    leukemia
    neuronitis


    CREBZF for disorders           About GeneDecksing


    Export disorders for CREBZF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREBZF gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CREBZF)
        Utopia: connect your pdf to the dynamic
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    1. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PubMed id 10871379)1, 2, 3 Lu R. and Misra V. (Nucleic Acids Res. 2000)
    2. Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)1, 2 Misra V.... Korchinski P. (J. Biol. Chem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. (PubMed id 24200963)1 Zhang R. and Misra V. (Cell Cycle 2014)
    5. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)
    6. The transcription factor CREBZF is a novel positive regulator of p53. (PubMed id 22983008)1 LA^pez-Mateo I....Belandia B. (Cell Cycle 2012)
    7. Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF. (PubMed id 22798206)1 Bodnarchuk T.W....Misra V. (J. Neurooncol. 2012)
    8. CREBZF, a novel Smad8-binding protein. (PubMed id 22707059)1 Lee J.H....Kim I.Y. (Mol. Cell. Biochem. 2012)
    9. SMILE silencing and PMA activation gene networks in HeLa cells: comparison with kidney transplantation gene networks. (PubMed id 22134986)1 RacapAc M....Nicolini C. (J. Cell. Biochem. 2012)
    10. The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response. (PubMed id 21603654)1 RacapAc M....Brouard S. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58487 HGNC: 24905 AceView: ZF Ensembl:ENSG00000137504 euGenes: HUgn58487
    ECgene: CREBZF H-InvDB: CREBZF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREBZF Pharmacogenomics, SNPs, Pathways

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    Patent Information for CREBZF gene:
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