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Aliases for CREBZF Gene

Aliases for CREBZF Gene

  • CREB/ATF BZIP Transcription Factor 2 3 5
  • Host Cell Factor-Binding Transcription Factor Zhangfei 3 4
  • HCF-Binding Transcription Factor Zhangfei 3 4
  • Zhangfei 2 3
  • ZF 3 4
  • SHP-Interacting Leucine Zipper Protein 3
  • SMILE 3

External Ids for CREBZF Gene

Previous GeneCards Identifiers for CREBZF Gene

  • GC11M085046
  • GC11M085368
  • GC11M081665

Summaries for CREBZF Gene

GeneCards Summary for CREBZF Gene

CREBZF (CREB/ATF BZIP Transcription Factor) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and MAPK-Erk Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and identical protein binding.

UniProtKB/Swiss-Prot for CREBZF Gene

  • Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBZF Gene

Genomics for CREBZF Gene

Regulatory Elements for CREBZF Gene

Enhancers for CREBZF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F086301 0.2 ENCODE 24.3 -619.6 -619637 1.9 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 CREBZF PRSS23 FZD4 HIKESHI RN7SL225P
GH11F085825 1.1 Ensembl ENCODE 20.9 -146.3 -146251 7.4 PKNOX1 INSM2 SIN3A FEZF1 ZBTB40 BRCA1 RAD21 ZNF366 SCRT2 RCOR1 CCDC83 CREBZF LOC100289518 CCDC89 SYTL2 ENSG00000279742
GH11F086243 0.5 ENCODE 19.1 -562.2 -562153 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 HIKESHI CREBZF PRSS23 FZD4 CCDC89 EED MIR6755 LOC100289518
GH11F085662 0.4 ENCODE 16.9 +18.3 18253 5.2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 CREBZF TMEM126A CCDC89 SYTL2 GC11M085678
GH11F085953 0.5 ENCODE 16.6 -270.8 -270775 0.1 SIN3A GLI4 YY1 ZNF335 KLF11 ZBTB11 REST POLR2H TFDP1 KLF16 CREBZF SLC25A1P1 PICALM
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CREBZF on UCSC Golden Path with GeneCards custom track

Promoters for CREBZF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001572047 207 1000 TBP L3MBTL2 NRF1 ZNF76 SP2 DMAP1 E2F4 POLR2A GATAD1 SCRT2

Genomic Location for CREBZF Gene

Chromosome:
11
Start:
85,657,564 bp from pter
End:
85,682,908 bp from pter
Size:
25,345 bases
Orientation:
Minus strand

Genomic View for CREBZF Gene

Genes around CREBZF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBZF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBZF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBZF Gene

Proteins for CREBZF Gene

  • Protein details for CREBZF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS37-ZHANG_HUMAN
    Recommended name:
    CREB/ATF bZIP transcription factor
    Protein Accession:
    Q9NS37
    Secondary Accessions:
    • B2R8Q9
    • Q0P5U9
    • Q52LT3

    Protein attributes for CREBZF Gene

    Size:
    354 amino acids
    Molecular mass:
    37134 Da
    Quaternary structure:
    • Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity.
    Miscellaneous:
    • Named Zhangfei after a legendary Chinese warrior who was contemporary with Luman in around 220 AD.
    SequenceCaution:
    • Sequence=AAD28325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD28325.1; Type=Frameshift; Positions=5, 49; Evidence={ECO:0000305}; Sequence=AAZ42189.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36256.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36256.1; Type=Frameshift; Positions=59; Evidence={ECO:0000305};

neXtProt entry for CREBZF Gene

Post-translational modifications for CREBZF Gene

  • Ubiquitination at Lys 184
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CREBZF Gene

Domains & Families for CREBZF Gene

Gene Families for CREBZF Gene

Protein Domains for CREBZF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBZF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS37

UniProtKB/Swiss-Prot:

ZHANG_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREBZF: view

Function for CREBZF Gene

Molecular function for CREBZF Gene

UniProtKB/Swiss-Prot Function:
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Gene Ontology (GO) - Molecular Function for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10871379
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 10871379
GO:0042802 identical protein binding IPI 16343488
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREBZF: view
genes like me logo Genes that share phenotypes with CREBZF: view

Animal Model Products

miRNA for CREBZF Gene

miRTarBase miRNAs that target CREBZF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBZF Gene

Localization for CREBZF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBZF Gene

Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREBZF Gene COMPARTMENTS Subcellular localization image for CREBZF gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15705566
genes like me logo Genes that share ontologies with CREBZF: view

Pathways & Interactions for CREBZF Gene

genes like me logo Genes that share pathways with CREBZF: view

Pathways by source for CREBZF Gene

Gene Ontology (GO) - Biological Process for CREBZF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA,IDA 10871379
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009615 response to virus IDA 10871379
GO:0045814 negative regulation of gene expression, epigenetic IEP 15705566
GO:0045892 negative regulation of transcription, DNA-templated IMP 15705566
genes like me logo Genes that share ontologies with CREBZF: view

No data available for SIGNOR curated interactions for CREBZF Gene

Transcripts for CREBZF Gene

Unigene Clusters for CREBZF Gene

CREB/ATF bZIP transcription factor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREBZF Gene

No ASD Table

Relevant External Links for CREBZF Gene

GeneLoc Exon Structure for
CREBZF
ECgene alternative splicing isoforms for
CREBZF

Expression for CREBZF Gene

mRNA expression in normal human tissues for CREBZF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CREBZF Gene

This gene is overexpressed in Pancreatic juice (37.9), Fetal Liver (20.4), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CREBZF Gene



Protein tissue co-expression partners for CREBZF Gene

NURSA nuclear receptor signaling pathways regulating expression of CREBZF Gene:

CREBZF

SOURCE GeneReport for Unigene cluster for CREBZF Gene:

Hs.535319

mRNA Expression by UniProt/SwissProt for CREBZF Gene:

Q9NS37-ZHANG_HUMAN
Tissue specificity: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.
genes like me logo Genes that share expression patterns with CREBZF: view

Primer Products

No data available for mRNA differential expression in normal tissues for CREBZF Gene

Orthologs for CREBZF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CREBZF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBZF 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia CREBZF 34 35
  • 92.09 (n)
cow
(Bos Taurus)
Mammalia CREBZF 34 35
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Crebzf 34 16 35
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Crebzf 34
  • 86.48 (n)
oppossum
(Monodelphis domestica)
Mammalia CREBZF 35
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBZF 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii crebzf 35
  • 42 (a)
OneToOne
Species where no ortholog for CREBZF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBZF Gene

ENSEMBL:
Gene Tree for CREBZF (if available)
TreeFam:
Gene Tree for CREBZF (if available)

Paralogs for CREBZF Gene

No data available for Paralogs for CREBZF Gene

Variants for CREBZF Gene

Sequence variations from dbSNP and Humsavar for CREBZF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1053466 -- 85,659,182(-) TTTTT(C/T)CCCCC nc-transcript-variant, utr-variant-3-prime
rs11234380 -- 85,660,455(+) AGTAA(A/T)TTGGG nc-transcript-variant, utr-variant-3-prime
rs11342231 -- 85,665,459(+) AGGAC(-/T)TTTTT upstream-variant-2KB
rs113731424 -- 85,658,649(+) GGCTT(-/A)AAAAA nc-transcript-variant, utr-variant-3-prime
rs11555656 -- 85,661,985(+) GTATA(C/T)ATATA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CREBZF Gene

Variant ID Type Subtype PubMed ID
esv2759845 CNV gain+loss 17122850

Variation tolerance for CREBZF Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREBZF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREBZF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBZF Gene

Disorders for CREBZF Gene

Relevant External Links for CREBZF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREBZF

No disorders were found for CREBZF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBZF Gene

Publications for CREBZF Gene

  1. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PMID: 10871379) Lu R. … Misra V. (Nucleic Acids Res. 2000) 2 3 4 64
  2. Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PMID: 15705566) Misra V. … Korchinski P. (J. Biol. Chem. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. (PMID: 24200963) Zhang R. … Misra V. (Cell Cycle 2014) 3 64
  5. Ursodeoxycholic acid inhibits liver X receptor I+-mediated hepatic lipogenesis via induction of the nuclear corepressor SMILE. (PMID: 24265317) Lee J.M. … Choi H.S. (J. Biol. Chem. 2014) 3 64

Products for CREBZF Gene

Sources for CREBZF Gene

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