Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CREBZF Gene

protein-coding GIFtS: 46
GCID: GC11M085368

CREB/ATF bZIP transcription factor

Explore 3 diseases affiliated with
CREBZF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CREB/ATF BZIP Transcription Factor¹ ²		SMILE²
ZF¹ ² ³		Zhangfei²
Host Cell Factor-Binding Transcription Factor Zhangfei² ³		SHP-Interacting Leucine Zipper Protein²
HCF-Binding Transcription Factor Zhangfei² ³

External Ids:	HGNC: 24905¹	Entrez Gene: 58487²	Ensembl: ENSG00000137504⁷	OMIM: 606444⁵	UniProtKB: Q9NS37³

Export aliases for CREBZF gene to outside databases

Previous GC identifers: GC11M085046 GC11M081665

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37

Function: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells

infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by

CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in

CREBZF-expressing cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CREBZF gene promoter:
PPAR-gamma1 S8 ATF-2 POU3F2 ATF6
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CREBZF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBZF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1

CREBZF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREBZF gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M085368: view genomic region (about GC identifiers)

Start:	85,368,608 bp from pter	End:	85,393,951 bp from pter
Size:	25,344 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37 (See protein sequence)

Recommended Name: CREB/ATF bZIP transcription factor

Size: 354 amino acids; 37134 Da

Subunit: Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity

Subcellular location: Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3

and HCFC1

Miscellaneous: Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD

Sequence caution: Sequence=AAD28325.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAD28325.1; Type=Frameshift; Positions=5, 49; Sequence=AAZ42189.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=BAG36256.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=BAG36256.1; Type=Frameshift; Positions=59;

Secondary accessions: B2R8Q9 Q0P5U9 Q52LT3

Explore the universe of human proteins at neXtProt for CREBZF: NX_Q9NS37

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NS37

CREBZF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001034707.1

ENSEMBL proteins:

ENSP00000434281 ENSP00000260058 ENSP00000435980 ENSP00000433380 ENSP00000435762

ENSP00000433459 ENSP00000381342

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CREBZF OriGene Custom Protein Services for CREBZF
	GenScript Custom Purified and Recombinant Proteins Services for CREBZF
	Novus Biologicals CREBZF Proteins Novus Biologicals CREBZF Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CREBZF

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15705566

CREBZF for ontologies About GeneDecksing

CREBZF Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CREBZF
	GenScript Custom Superior Antibodies Services for CREBZF
	Novus Biologicals CREBZF Antibodies
	Search for Antibodies for CREBZF at Abcam
	Uscn Antibodies for CREBZF
	ThermoFisher Antibodies for CREBZF

Assay Products for CREBZF:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CREBZF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CREBZF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CREBZF for domains About GeneDecksing

1 InterPro domain/family:

IPR004827 bZIP

Graphical View of Domain Structure for InterPro Entry Q9NS37

ProtoNet protein and cluster: Q9NS37

1 Blocks protein family: IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37

Similarity: Belongs to the bZIP family. ATF subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37

Function: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells

infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by

CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in

CREBZF-expressing cells

miRNA Products:		OriGene 3'-UTR Clone: CREBZF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREBZF
		8/236 QIAGEN miScript miRNA Assays for microRNAs that regulate CREBZF (see all 236):
		hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-4275 hsa-miR-409-5p hsa-miR-208b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREBZF (see all 7) OriGene shRNA RFP: CREBZF OriGene siRNA: CREBZF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREBZF

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CREBZF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CREBZF (NM_001039618)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREBZF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBZF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CREBZF
		Search LifeMap BioReagents cell lines for CREBZF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBZF

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	10871379
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	19690166
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	--	--

CREBZF for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CREBZF

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/18 Interacting proteins for CREBZF (Q9NS37^{1, 2, 3} ENSP00000260058⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HCFC1	P51610¹^,³, ENSP00000309555⁴	EBI-632965,EBI-2832627 I2D: score=4 STRING: ENSP00000309555
ZNF512B	Q96KM6²^,³	MINT-60790 I2D: score=2
ATF4	P18848²^,³, ENSP00000336790⁴	MINT-73538 MINT-73537 MINT-73540 MINT-73535 MINT-73539 I2D: score=2 STRING: ENSP00000336790
CREB3	O43889³, ENSP00000342136⁴	I2D: score=2 STRING: ENSP00000342136
CREBZF	Q9NS37²	MINT-77962 MINT-77963

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IDA	10871379
GO:0009615	response to virus	IDA	10871379
GO:0045814	negative regulation of gene expression, epigenetic	IEP	15705566
GO:0045892	negative regulation of transcription, DNA-dependent	IMP	15705566
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	IDA	15705566

CREBZF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CREBZF
Search CenterWatch for drugs/clinical trials and news about CREBZF / ZHANG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CREBZF gene (2 alternative transcripts):

NM_021212.1 NM_001039618.2

Unigene Cluster for CREBZF:

CREB/ATF bZIP transcription factor

Hs.535319 [show with all ESTs]

Unigene Representative Sequence: NM_001039618

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000490820(uc010rtc.1 uc010rtd.1) ENST00000528561 ENST00000260058

ENST00000531515 ENST00000534224 ENST00000527529 ENST00000525639 ENST00000527447(uc001pas.2)

ENST00000528889 ENST00000398294

miRNA Products:		OriGene 3'-UTR Clone: CREBZF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CREBZF
		8/236 QIAGEN miScript miRNA Assays for microRNAs that regulate CREBZF (see all 236):
		hsa-miR-199a-3p hsa-miR-1224-3p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-519a hsa-miR-4275 hsa-miR-409-5p hsa-miR-208b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREBZF (see all 7) OriGene shRNA RFP: CREBZF OriGene siRNA: CREBZF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREBZF

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CREBZF (NM_001039618)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREBZF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBZF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBZF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CREBZF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBZF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBZF

Additional cDNA sequence:

AF039942.1 AK313471.1 AL110236.1 BC060807.1 BC093796.1 BC093798.1 DQ128105.1 NR_028024.1

NR_028025.1 NR_028026.1 NR_028027.1

14 DOTS entries:

DT.99948953 DT.113518 DT.102830357 DT.91764277 DT.120719112 DT.100730999 DT.95212322 DT.100787984

DT.91978464 DT.100711616 DT.120719127 DT.120729870 DT.91764283 DT.95339610

24/458 AceView cDNA sequences (see all 458):

AA829972 AA331655 CB269781 AI493996 AW183422 AI870261 N50895 BE924965

AW963804 BE502472 AI089333 BM725415 BE696875 BQ720558 AA568696 AA911004

AA521332 AI222792 BF593892 AA827753 AA404580 AA570409 AI598007 AI351382

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CREBZF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGCTAATT

About this image

CREBZF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CREBZF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREBZF

SOURCE GeneReport for Unigene cluster: Hs.535319

UniProtKB/Swiss-Prot: ZHANG_HUMAN, Q9NS37

Tissue specificity: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in

kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low

amounts in heart, lung and liver

SABiosciences Custom PCR Arrays for CREBZF

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBZF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CREBZF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBZF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBZF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBZF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CREBZF gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Crebzf^{1 , 5}	CREB/ATF bZIP transcription factor^{1, 5}	86.89(n)¹ 84.33(a)¹		7 (50.59 cM)⁵ 233490¹ NM_145151.2¹ NP_660133.2¹ 90442729⁵
lizard (Anolis carolinensis)	Reptilia	CREBZF⁶	--	57(a)	1 ↔ 1	3(200663790-200664341)
zebrafish (Danio rerio)	Actinopterygii	wu:fj46h08⁶	wu:fj46h08	39(a)	1 ↔ 1	10(30007230-30007988)

ENSEMBL Gene Tree for CREBZF (if available)
TreeFam Gene Tree for CREBZF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55945805^1,2	F,	--	85368127(+)	`TTAGAA/TTCACA`	5	--	ds500¹		2		NA EA	240
rs190858854^1,2		--	85368140(+)	`ATTAAC/GTAATC`	5	--	ds500¹		0	--	--	--	--
rs183962109^1,2		--	85368352(+)	`AGCCAC/GTAGCC`	5	--	ds500¹		0	--	--	--	--
rs140365466^1,2		--	85368357(+)	`CTAGCC/TTATGT`	5	--	ds500¹		0	--	--	--	--
rs186537273^1,2		--	85368520(+)	`AAAAGA/TACCAA`	5	--	ds500¹		0	--	--	--	--
rs190595498^1,2		--	85368539(+)	`TTAAGA/TGGCAT`	5	--	ds500¹		0	--	--	--	--
rs150381836^1,2		--	85368577(+)	`ATTACC/TTCCAA`	5	--	ds500¹		0	--	--	--	--
rs183196172^1,2		--	85368711(+)	`GATGAA/GAAACT`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs80318160^1,2	F,	--	85368745(+)	`TCTCAA/GTTTTT`	5	--	ut3¹ nc-transcript-variant		1		WA	118
rs144869019^1,2		--	85368764(+)	`AAAGAC/TGATTT`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for CREBZF (85368608 - 85393951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CREBZF
1 CNV: 3860

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBZF

DNA2.0 Custom Variant and Variant Library Synthesis for CREBZF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CREBZF for disorders           About GeneDecksing

OMIM gene information: 606444    OMIM disorders: --

3 diseases for CREBZF:    About MalaCards

herpes simplex medulloblastoma neuronitis

Export disorders for CREBZF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CREBZF gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CREBZF)

Utopia: connect your pdf to the dynamic
world of online information

Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16. (PubMed id 10871379)^{1, 2, 3} Lu R. and Misra V. (2000)
Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)^{1, 2} Misra V.... Korchinski P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
CREBZF, a novel Smad8-binding protein. (PubMed id 22707059)¹ Lee J.H....Kim I.Y. (2012)
SMILE silencing and PMA activation gene networks in He La cells: comparison with kidney transplantation gene networks. (PubMed id 22134986)¹ Racape M....Nicolini C. (2012)
The involvement of SMILE/TMTC3 in endoplasmic reticul um stress response. (PubMed id 21603654)¹ RacapAc M....Brouard S. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Curcumin differentially regulates endoplasmic reticulu m stress through transcriptional corepressor SMILE (small heterodimer partner-in teracting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). (PubMed id 21994947)¹ Misra J....Choi H.S. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis. (PubMed id 18719857)¹ Valderrama X....Misra V. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58487	HGNC: 24905	AceView: ZF	Ensembl:ENSG00000137504	euGenes: HUgn58487
ECgene: CREBZF	H-InvDB: CREBZF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CREBZF	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CREBZF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CREBZF gene:
Search GeneIP for patents involving CREBZF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CREBZF
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREBZF		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBZF
	OriGene Protein Over-expression Lysate for CREBZF		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CREBZF		OriGene 3'-UTR Clone for CREBZF
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBZF
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CREBZF		OriGene Custom Protein Services for CREBZF
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREBZF
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBZF
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBZF
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREBZF
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBZF
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBZF

	GenScript Custom Purified and Recombinant Proteins Services for CREBZF		GenScript cDNA clones with any tag delivered in your preferred vector for CREBZF
	GenScript Custom Assay Services for CREBZF		GenScript Custom Superior Antibodies Services for CREBZF
	GenScript Custom overexpressing Cell Line Services for CREBZF		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CREBZF promoter
	Search Chromatin IP Primers for CREBZF
	RT² qPCR Primer Assay in human, mouse, rat CREBZF
	GNC Network for CREBZF
	SABiosciences Custom PCR Arrays for CREBZF

Search Tocris compounds for CREBZF

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CREBZF antibodies
	CREBZF proteins
	CREBZF lysates

	Search for Antibodies for CREBZF at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CREBZF
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CREBZF Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CREBZF

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBZF

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CREBZF
	Browse SwitchGear Promoter luciferase reporter plasmids for CREBZF

ThermoFisher Antibodies for CREBZF

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBZF

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CREBZF gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CREBZF Gene

CREB/ATF bZIP transcription factor

Aliases
for CREBZF gene

Summaries
for CREBZF gene

Genomic Views
for CREBZF gene

Proteins
for CREBZF gene

Protein Domains /
Families
for CREBZF gene

Function
for CREBZF gene

Pathways & Interactions
for CREBZF gene

Drugs & Compounds
for CREBZF gene

Transcripts
for CREBZF gene

Expression
for CREBZF gene

Orthologs
for CREBZF gene

Paralogs
for CREBZF gene

Genomic Variants
for CREBZF gene

Disorders / Diseases
for CREBZF gene

Publications
for CREBZF gene

External Searches for CREBZF gene

Genome Databases showing CREBZF gene

Other Databases showing CREBZF gene

Specialized Databases showing CREBZF gene

Intellectual Property
for CREBZF gene

Products
for CREBZF gene

View Random Gene

Advanced Search

Export list of displayed genes

CREBZF Gene

CREB/ATF bZIP transcription factor

Aliasesfor CREBZF gene

Summariesfor CREBZF gene

Genomic Viewsfor CREBZF gene

Proteinsfor CREBZF gene

Protein Domains /Familiesfor CREBZF gene

Functionfor CREBZF gene

Pathways & Interactionsfor CREBZF gene

Drugs & Compoundsfor CREBZF gene

Transcriptsfor CREBZF gene

Expression for CREBZF gene

Orthologsfor CREBZF gene

Paralogsfor CREBZF gene

Genomic Variantsfor CREBZF gene

Disorders / Diseasesfor CREBZF gene

Publicationsfor CREBZF gene

External Searches for CREBZF gene

Genome Databases showing CREBZF gene

Other Databases showing CREBZF gene

Specialized Databases showing CREBZF gene

Intellectual Propertyfor CREBZF gene

Productsfor CREBZF gene

View Random Gene

Aliases
for CREBZF gene

Summaries
for CREBZF gene

Genomic Views
for CREBZF gene

Proteins
for CREBZF gene

Protein Domains /
Families
for CREBZF gene

Function
for CREBZF gene

Pathways & Interactions
for CREBZF gene

Drugs & Compounds
for CREBZF gene

Transcripts
for CREBZF gene

Expression
for CREBZF gene

Orthologs
for CREBZF gene

Paralogs
for CREBZF gene

Genomic Variants
for CREBZF gene

Disorders / Diseases
for CREBZF gene

Publications
for CREBZF gene

Intellectual Property
for CREBZF gene

Products
for CREBZF gene