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CREBRF Gene

protein-coding   GIFtS: 37
GCID: GC05P172484

CREB3 Regulatory Factor

(Previous name: chromosome 5 open reading frame 41)
(Previous symbol: C5orf41)
  Search for CREBRF
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CREB3 Regulatory Factor1 2     Chromosome 5 Open Reading Frame 411
C5orf411 2 3     Adult Retina Protein2
Luman/CREB3 Recruitment Factor1 2     Luman-Recruiting Factor2
Luman Recruitment Factor2 3     UPF0474 Protein C5orf412
LRF2 3     

External Ids:    HGNC: 240501   Entrez Gene: 1532222   Ensembl: ENSG000001644637   UniProtKB: Q8IUR63   

Export aliases for CREBRF gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CREBRF Gene:
CREBRF (CREB3 regulatory factor) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6
Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response
(UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CREBRF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREBRF promoter sequence
   Search Chromatin IP Primers for CREBRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREBRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.2

CREBRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREBRF gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P172484:  view genomic region     (about GC identifiers)

Start:
172,483,355 bp from pter      End:
172,566,291 bp from pter
Size:
82,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6 (See protein sequence)
Recommended Name: CREB3 regulatory factor  
Size: 639 amino acids; 72149 Da
Subunit: Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes
CREB3 degradation
Sequence caution: Sequence=AC008378; Type=Erroneous gene model prediction;
Secondary accessions: B3DFH2 B3KW49 D3DQM2 F5GXN3 Q5HYG4 Q5HYK0 Q86YR3 Q8IZG1
Alternative splicing: 3 isoforms:  Q8IUR6-1   Q8IUR6-2   Q8IUR6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CREBRF: NX_Q8IUR6

Explore proteomics data for CREBRF at MOPED

Post-translational modifications: 

  • Probably degraded by the proteasome1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CREBRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001161865.1  NP_001161866.1  NP_705835.2  

    ENSEMBL proteins: 
     ENSP00000431107   ENSP00000296953   ENSP00000428290   ENSP00000430801   ENSP00000440075  

    CREBRF Human Recombinant Protein Products:

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    Novus Biologicals CREBRF Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CREBRF 

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    LSBio Antibodies in human, mouse, rat for CREBRF

    CREBRF Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CREBRF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q8IUR6

    ProtoNet protein and cluster: Q8IUR6

    UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6
    Similarity: Belongs to the bZIP family. CREBRF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CREBRF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRERF_HUMAN, Q8IUR6
    Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response
    (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci
    Induction: Up-regulated by endoplasmic reticulum stress

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18391022
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with CREBRF           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CREBRF:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREBRF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CREBRF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREBRF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREBRF

    miRNA
    Products:
        
    miRTarBase miRNAs that target CREBRF:
    hsa-mir-421 (MIRT016126), hsa-mir-93-5p (MIRT028082), hsa-mir-484 (MIRT042350), hsa-mir-335-5p (MIRT017940), hsa-mir-155-5p (MIRT005103), hsa-mir-186-5p (MIRT045087)

    Block miRNA regulation of human, mouse, rat CREBRF using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCREBRF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREBRF

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBRF

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBRF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRERF_HUMAN, Q8IUR6: Nucleus. Note=Colocalizes with CREB3 in nuclear foci

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA18391022
    GO:0016604nuclear body IDA18391022

    Find genes that share ontologies with CREBRF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREBRF
    Interactions:

        Search GeneGlobe Interaction Network for CREBRF

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CREBRF (Q8IUR61, 3 ENSP000002969534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2BP2O954003, ENSP000003049034I2D: score=2 STRING: ENSP00000304903
    CREB3O43889-21, ENSP000003421364EBI-1042699,EBI-625022 STRING: ENSP00000342136
    ZBTB7AENSP000003236704STRING: ENSP00000323670
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18391022
    GO:0006351transcription, DNA-templated IEA--
    GO:0006810transport IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0032388positive regulation of intracellular transport IDA18391022

    Find genes that share ontologies with CREBRF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREBRF (CRERF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CREBRF gene (3 alternative transcripts): 
    NM_001168393.1  NM_001168394.1  NM_153607.2  

    Unigene Cluster for CREBRF:

    CREB3 regulatory factor
    Hs.484195  [show with all ESTs]
    Unigene Representative Sequence: NM_153607
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522692(uc003mcf.3 uc003mcg.3) ENST00000296953(uc011dfd.1)
    ENST00000520420 ENST00000520464 ENST00000517882 ENST00000523161 ENST00000540014(uc003mch.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat CREBRF using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CREBRF
    SwitchGear 3'UTR luciferase reporter plasmidCREBRF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CREBRF
    Predesigned siRNA for gene silencing in human, mouse, rat CREBRF
    Clone
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    GenScript Custom all cDNA clones Services for CREBRF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREBRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBRF
    Primer
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    OriGene qPCR primer pairs and template standards for CREBRF
    OriGene qSTAR qPCR primer pairs in human, mouse for CREBRF
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CREBRF
      QuantiTect SYBR Green Assays in human, mouse, rat CREBRF
      QuantiFast Probe-based Assays in human, mouse, rat CREBRF

    Additional mRNA sequence: 

    AK122675.1 AK124117.1 AK291677.1 AK297424.1 AK300043.1 AY139008.1 AY174896.1 AY635785.1 
    BC041709.1 BC043185.2 BX647768.1 

    9 DOTS entries:

    DT.91991182  DT.92052308  DT.451573  DT.95210676  DT.120813712  DT.65288542  DT.95272153  DT.405613 
    DT.92027438 

    Selected AceView cDNA sequences (see all 169):

    AW768436 AI307396 BG150109 AA481254 AY139008 AI307750 AW173127 BQ027319 
    BX118518 BU675820 BM680023 BX647768 BX476538 AA437223 N50563 BM682460 
    AI808566 AA768851 AA290875 AA243634 AI276414 CA313542 AK124117 AI743558 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREBRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCTCAT
    CREBRF Expression
    About this image

    CREBRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREBRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484195
        Custom PCR Arrays for CREBRF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREBRF gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crebrf1 , 5 RIKEN cDNA A930001N09 gene5
    CREB3 regulatory factor1
    89.88(n)1
    93.9(a)1
      17 (13.50 cM)5
    771281  NM_029870.21  NP_084146.11 
     267156505 
    chicken
    (Gallus gallus)
    Aves C13H5ORF411 chromosome 13 open reading frame, human C5orf41 80.67(n)
    86.53(a)
      416206  XM_004944871.1  XP_004944928.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREBRF6
    CREB3 regulatory factor
    82(a)
    1 ↔ 1
    2(124536117-124554236)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crebrf1 CREB3 regulatory factor 70.82(n)
    77.32(a)
      100490775  XM_004912845.1  XP_004912902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crebrf1 creb3 regulatory factor 70.48(n)
    79.24(a)
      100149876  XM_005170286.1  XP_005170343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136246
    --
    17(a)
    1 ↔ 1
    3R(20383090-20408586)


    ENSEMBL Gene Tree for CREBRF (if available)
    TreeFam Gene Tree for CREBRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREBRF (see all 1488)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs297771,2
    C,F,A,H--172481414(-) GCAGCC/GAGGTT 3 -- us2k110Minor allele frequency- G:0.31NA CSA WA EA 371
    rs1479013771,2
    --172481461(+) AACGTA/GCCCGT 3 -- us2k10--------
    rs777860121,2
    F--172481560(+) TATGCC/TGGGGA 3 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1884721811,2
    --172481597(+) CGAGTA/C/TGGGGT 3 -- us2k10--------
    rs1416843231,2
    --172481750(+) CCTTCA/TTTGGG 3 -- us2k10--------
    rs784628581,2
    C,F--172481753(+) TCATTG/AGGCAT 3 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1917078691,2
    --172481796(+) GCTACA/GGAGGA 3 -- us2k10--------
    rs297761,2
    C,F,A,H--172481818(-) GGAAAC/GTAAAA 3 -- us2k131Minor allele frequency- G:0.37NS EA NA CSA WA 3185
    rs1843009921,2
    --172482106(+) GTTAAA/TTTGTG 3 -- us2k10--------
    rs2019052391,2
    --172482379(+) TTATT-/CCCCCGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREBRF (172483355 - 172566291 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CREBRF: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREBRF
    DNA2.0 Custom Variant and Variant Library Synthesis for CREBRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREBRF gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CREBRF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PubMed id 18391022)1, 2, 3 Audas T.E.... Lu R. (Mol. Cell. Biol. 2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. (PubMed id 23071095)1 Martyn A.C....Lu R. (Mol. Cell. Biol. 2012)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153222 HGNC: 24050 AceView: LOC153222 Ensembl:ENSG00000164463 euGenes: HUgn153222
    ECgene: CREBRF H-InvDB: CREBRF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREBRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREBRF gene:
    Search GeneIP for patents involving CREBRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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