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Aliases for CREBRF Gene

Aliases for CREBRF Gene

  • CREB3 Regulatory Factor 2 3 5
  • Luman/CREB3 Recruitment Factor 2 3
  • Luman Recruitment Factor 3 4
  • C5orf41 3 4
  • LRF 3 4
  • Chromosome 5 Open Reading Frame 41 2
  • UPF0474 Protein C5orf41 3
  • Luman-Recruiting Factor 3
  • Adult Retina Protein 3

External Ids for CREBRF Gene

Previous HGNC Symbols for CREBRF Gene

  • C5orf41

Previous GeneCards Identifiers for CREBRF Gene

  • GC05P172484

Summaries for CREBRF Gene

GeneCards Summary for CREBRF Gene

CREBRF (CREB3 Regulatory Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBRF Gene

  • Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBRF Gene

Genomics for CREBRF Gene

Regulatory Elements for CREBRF Gene

Enhancers for CREBRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F172763 1.6 VISTA FANTOM5 ENCODE 34.7 -284.2 -284150 16.8 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DUSP1 CREBRF KLF3P1 ERGIC1 ENSG00000253628 ENSG00000253172 ENSG00000253110 SMIM23 UBTD2 EFCAB9
GH05F173143 0.4 ENCODE 18.1 +88.4 88391 1.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SH3PXD2B CREBRF CDC42P5 BOD1 BNIP1 ENSG00000253172
GH05F172274 1.5 FANTOM5 Ensembl ENCODE 17.9 -780.6 -780635 2.6 PKNOX1 KLF17 THRB BRCA1 ZEB1 ZNF366 CBX5 ZNF143 RCOR1 ZNF548 NPM1 SH3PXD2B UBTD2 CREBRF EFCAB9 ENSG00000212529 RPL10P8 STK10 DUSP1 KLF3P1
GH05F172832 1.1 FANTOM5 ENCODE 14.4 -220.7 -220656 6.5 PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 YY1 ZNF143 PAF1 SP3 CREBRF DUSP1 ERGIC1 RPL26L1
GH05F173014 0.8 FANTOM5 Ensembl ENCODE 13.2 -39.6 -39649 4.6 ATF1 PKNOX1 ARID4B ZNF766 FOS DEK NFYC NCOA1 PPARG TBX21 CREBRF ENSG00000207210 ATP6V0E1 ENSG00000254328 LOC100268168 ENSG00000254295 RPL26L1 BNIP1 ENSG00000253172 LOC401218
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CREBRF on UCSC Golden Path with GeneCards custom track

Promoters for CREBRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297006 751 3001 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CREBRF Gene

Chromosome:
5
Start:
173,056,349 bp from pter
End:
173,139,293 bp from pter
Size:
82,945 bases
Orientation:
Plus strand

Genomic View for CREBRF Gene

Genes around CREBRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBRF Gene

Proteins for CREBRF Gene

  • Protein details for CREBRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR6-CRERF_HUMAN
    Recommended name:
    CREB3 regulatory factor
    Protein Accession:
    Q8IUR6
    Secondary Accessions:
    • B3DFH2
    • B3KW49
    • D3DQM2
    • F5GXN3
    • Q5HYG4
    • Q5HYK0
    • Q86YR3
    • Q8IZG1

    Protein attributes for CREBRF Gene

    Size:
    639 amino acids
    Molecular mass:
    72149 Da
    Quaternary structure:
    • Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.
    SequenceCaution:
    • Sequence=AC008378; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CREBRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREBRF Gene

Post-translational modifications for CREBRF Gene

No data available for DME Specific Peptides for CREBRF Gene

Domains & Families for CREBRF Gene

Protein Domains for CREBRF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUR6

UniProtKB/Swiss-Prot:

CRERF_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. CREBRF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CREBRF subfamily.
genes like me logo Genes that share domains with CREBRF: view

No data available for Gene Families for CREBRF Gene

Function for CREBRF Gene

Molecular function for CREBRF Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 18391022
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREBRF: view
genes like me logo Genes that share phenotypes with CREBRF: view

Animal Model Products

miRNA for CREBRF Gene

miRTarBase miRNAs that target CREBRF

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBRF Gene

Localization for CREBRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBRF Gene

Nucleus. Note=Colocalizes with CREB3 in nuclear foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREBRF Gene COMPARTMENTS Subcellular localization image for CREBRF gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with CREBRF: view

Pathways & Interactions for CREBRF Gene

SuperPathways for CREBRF Gene

No Data Available

Interacting Proteins for CREBRF Gene

Gene Ontology (GO) - Biological Process for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0006986 response to unfolded protein IEA --
GO:0042711 maternal behavior IEA --
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Pathways by source and SIGNOR curated interactions for CREBRF Gene

Transcripts for CREBRF Gene

Unigene Clusters for CREBRF Gene

CREB3 regulatory factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREBRF Gene

No ASD Table

Relevant External Links for CREBRF Gene

GeneLoc Exon Structure for
CREBRF
ECgene alternative splicing isoforms for
CREBRF

Expression for CREBRF Gene

mRNA expression in normal human tissues for CREBRF Gene

mRNA differential expression in normal tissues according to GTEx for CREBRF Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CREBRF Gene

This gene is overexpressed in Liver, secretome (24.9), Platelet (8.9), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CREBRF Gene



NURSA nuclear receptor signaling pathways regulating expression of CREBRF Gene:

CREBRF

SOURCE GeneReport for Unigene cluster for CREBRF Gene:

Hs.484195
genes like me logo Genes that share expression patterns with CREBRF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CREBRF Gene

Orthologs for CREBRF Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBRF 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia CREBRF 34 35
  • 95.04 (n)
cow
(Bos Taurus)
Mammalia CREBRF 35
  • 94 (a)
OneToOne
C20H5orf41 34
  • 93.95 (n)
oppossum
(Monodelphis domestica)
Mammalia CREBRF 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crebrf 34
  • 90.51 (n)
mouse
(Mus musculus)
Mammalia Crebrf 34 16 35
  • 89.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CREBRF 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF41 34 35
  • 80.67 (n)
lizard
(Anolis carolinensis)
Reptilia CREBRF 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crebrf 34
  • 70.82 (n)
zebrafish
(Danio rerio)
Actinopterygii crebrf 34 35
  • 70.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13624 35
  • 17 (a)
OneToOne
Species where no ortholog for CREBRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBRF Gene

ENSEMBL:
Gene Tree for CREBRF (if available)
TreeFam:
Gene Tree for CREBRF (if available)

Paralogs for CREBRF Gene

No data available for Paralogs for CREBRF Gene

Variants for CREBRF Gene

Sequence variations from dbSNP and Humsavar for CREBRF Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002620 -- 173,084,334(+) CAACA(A/G)CACAC intron-variant
rs10038814 -- 173,094,702(+) ggttt(G/T)cagat intron-variant
rs10052434 -- 173,085,518(+) ttcaa(A/G)cgatt intron-variant
rs10054054 -- 173,058,428(+) GCATT(A/G)TCTTC intron-variant
rs10055297 -- 173,133,057(+) GAAGA(C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREBRF Gene

Variant ID Type Subtype PubMed ID
esv2662674 CNV deletion 23128226
esv2731109 CNV deletion 23290073
esv3607606 CNV loss 21293372
esv3607607 CNV loss 21293372
esv3607608 CNV loss 21293372
nsv1137048 CNV deletion 24896259
nsv507310 OTHER sequence alteration 20534489
nsv980753 CNV duplication 23825009

Variation tolerance for CREBRF Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREBRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CREBRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBRF Gene

Disorders for CREBRF Gene

Relevant External Links for CREBRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREBRF

No disorders were found for CREBRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBRF Gene

Publications for CREBRF Gene

  1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PMID: 18391022) Audas T.E. … Lu R. (Mol. Cell. Biol. 2008) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 64
  4. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. (PMID: 23071095) Martyn A.C. … Lu R. (Mol. Cell. Biol. 2012) 3 64
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3 64

Products for CREBRF Gene

Sources for CREBRF Gene

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