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Aliases for CREBRF Gene

Aliases for CREBRF Gene

  • CREB3 Regulatory Factor 2 3
  • Luman/CREB3 Recruitment Factor 2 3
  • Luman Recruitment Factor 3 4
  • C5orf41 3 4
  • LRF 3 4
  • Chromosome 5 Open Reading Frame 41 2
  • UPF0474 Protein C5orf41 3
  • Luman-Recruiting Factor 3
  • Adult Retina Protein 3

External Ids for CREBRF Gene

Previous Symbols for CREBRF Gene

  • C5orf41

Summaries for CREBRF Gene

GeneCards Summary for CREBRF Gene

CREBRF (CREB3 Regulatory Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBRF Gene

  • Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBRF Gene

Genomics for CREBRF Gene

Genomic Location for CREBRF Gene

Start:
173,056,352 bp from pter
End:
173,139,293 bp from pter
Size:
82,942 bases
Orientation:
Plus strand

Genomic View for CREBRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREBRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBRF Gene

No data available for Regulatory Elements for CREBRF Gene

Proteins for CREBRF Gene

  • Protein details for CREBRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR6-CRERF_HUMAN
    Recommended name:
    CREB3 regulatory factor
    Protein Accession:
    Q8IUR6
    Secondary Accessions:
    • B3DFH2
    • B3KW49
    • D3DQM2
    • F5GXN3
    • Q5HYG4
    • Q5HYK0
    • Q86YR3
    • Q8IZG1

    Protein attributes for CREBRF Gene

    Size:
    639 amino acids
    Molecular mass:
    72149 Da
    Quaternary structure:
    • Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.
    SequenceCaution:
    • Sequence=AC008378; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CREBRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREBRF Gene

Proteomics data for CREBRF Gene at MOPED

Post-translational modifications for CREBRF Gene

Other Protein References for CREBRF Gene

No data available for DME Specific Peptides for CREBRF Gene

Domains for CREBRF Gene

Protein Domains for CREBRF Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IUR6

UniProtKB/Swiss-Prot:

CRERF_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q8IUR6
Family:
  • Belongs to the bZIP family. CREBRF subfamily.:
    • Q8IUR6
genes like me logo Genes that share domains with CREBRF: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CREBRF Gene

Function for CREBRF Gene

Molecular function for CREBRF Gene

UniProtKB/Swiss-Prot Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
UniProtKB/Swiss-Prot Induction: Up-regulated by endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 18391022
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREBRF: view

Phenotypes for CREBRF Gene

GenomeRNAi human phenotypes for CREBRF:
genes like me logo Genes that share phenotypes with CREBRF: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CREBRF Gene

Localization for CREBRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBRF Gene

Nucleus. Note=Colocalizes with CREB3 in nuclear foci.

Gene Ontology (GO) - Cellular Components for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 18391022
GO:0016604 nuclear body IDA 18391022
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Subcellular locations from COMPARTMENTS for CREBRF Gene

Pathways for CREBRF Gene

SuperPathways for CREBRF Gene

No Data Available

Interacting Proteins for CREBRF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296953%0d%0a9606.ENSP00000342136%0d%0a9606.ENSP00000304903%0d%0a
Selected Interacting proteins: ENSP00000296953 Q8IUR6-CRERF_HUMAN for CREBRF Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18391022
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0006986 response to unfolded protein IEA --
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Pathways by source for CREBRF Gene

Transcripts for CREBRF Gene

Unigene Clusters for CREBRF Gene

CREB3 regulatory factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREBRF Gene

No ASD Table

Relevant External Links for CREBRF Gene

GeneLoc Exon Structure for
CREBRF
ECgene alternative splicing isoforms for
CREBRF

Expression for CREBRF Gene

mRNA expression in normal human tissues for CREBRF Gene

mRNA differential expression in normal tissues according to GTEx for CREBRF Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CREBRF Gene

SOURCE GeneReport for Unigene cluster for CREBRF Gene Hs.484195

genes like me logo Genes that share expressions with CREBRF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CREBRF Gene

Orthologs for CREBRF Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBRF 35
  • 99.9 (n)
  • 100 (a)
CREBRF 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C20H5orf41 35
  • 93.95 (n)
  • 97.97 (a)
CREBRF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREBRF 35
  • 95.04 (n)
  • 98.44 (a)
CREBRF 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crebrf 35
  • 89.88 (n)
  • 93.9 (a)
Crebrf 16
Crebrf 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREBRF 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREBRF 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crebrf 35
  • 90.51 (n)
  • 94.52 (a)
chicken
(Gallus gallus)
Aves C13H5ORF41 35
  • 80.67 (n)
  • 86.53 (a)
C13H5ORF41 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBRF 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crebrf 35
  • 70.82 (n)
  • 77.32 (a)
zebrafish
(Danio rerio)
Actinopterygii crebrf 35
  • 70.48 (n)
  • 79.24 (a)
crebrf 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13624 36
  • 17 (a)
OneToOne
Species with no ortholog for CREBRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBRF Gene

ENSEMBL:
Gene Tree for CREBRF (if available)
TreeFam:
Gene Tree for CREBRF (if available)

Paralogs for CREBRF Gene

No data available for Paralogs for CREBRF Gene

Variants for CREBRF Gene

Sequence variations from dbSNP and Humsavar for CREBRF Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2412 -- 173,082,506(-) CAAAC(C/T)GGACT intron-variant
rs29775 -- 173,056,020(+) GCAAA(A/C)GGACA upstream-variant-2KB
rs29776 -- 173,054,815(-) GGAAA(C/G)TAAAA upstream-variant-2KB
rs29777 -- 173,054,411(-) GCAGC(C/G)AGGTT upstream-variant-2KB
rs29779 -- 173,112,643(-) ATAAA(C/T)AAATT intron-variant

Relevant External Links for CREBRF Gene

HapMap Linkage Disequilibrium report
CREBRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CREBRF Gene

Disorders for CREBRF Gene

No disorders were found for CREBRF Gene.

No data available for UniProtKB/Swiss-Prot for CREBRF Gene

Publications for CREBRF Gene

  1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PMID: 18391022) Audas T.E. … Lu R. (Mol. Cell. Biol. 2008) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. (PMID: 23071095) Martyn A.C. … Lu R. (Mol. Cell. Biol. 2012) 3

Products for CREBRF Gene

Sources for CREBRF Gene

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