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Aliases for CREBRF Gene

Aliases for CREBRF Gene

  • CREB3 Regulatory Factor 2 3 5
  • Luman/CREB3 Recruitment Factor 2 3
  • Luman Recruitment Factor 3 4
  • C5orf41 3 4
  • LRF 3 4
  • Chromosome 5 Open Reading Frame 41 2
  • UPF0474 Protein C5orf41 3
  • Luman-Recruiting Factor 3
  • Adult Retina Protein 3

External Ids for CREBRF Gene

Previous HGNC Symbols for CREBRF Gene

  • C5orf41

Previous GeneCards Identifiers for CREBRF Gene

  • GC05P172484

Summaries for CREBRF Gene

GeneCards Summary for CREBRF Gene

CREBRF (CREB3 Regulatory Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBRF Gene

  • Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBRF Gene

Genomics for CREBRF Gene

Regulatory Elements for CREBRF Gene

Promoters for CREBRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CREBRF on UCSC Golden Path with GeneCards custom track

Genomic Location for CREBRF Gene

Chromosome:
5
Start:
173,056,349 bp from pter
End:
173,139,293 bp from pter
Size:
82,945 bases
Orientation:
Plus strand

Genomic View for CREBRF Gene

Genes around CREBRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBRF Gene

Proteins for CREBRF Gene

  • Protein details for CREBRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUR6-CRERF_HUMAN
    Recommended name:
    CREB3 regulatory factor
    Protein Accession:
    Q8IUR6
    Secondary Accessions:
    • B3DFH2
    • B3KW49
    • D3DQM2
    • F5GXN3
    • Q5HYG4
    • Q5HYK0
    • Q86YR3
    • Q8IZG1

    Protein attributes for CREBRF Gene

    Size:
    639 amino acids
    Molecular mass:
    72149 Da
    Quaternary structure:
    • Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3 degradation.
    SequenceCaution:
    • Sequence=AC008378; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CREBRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREBRF Gene

Proteomics data for CREBRF Gene at MOPED

Post-translational modifications for CREBRF Gene

Other Protein References for CREBRF Gene

No data available for DME Specific Peptides for CREBRF Gene

Domains & Families for CREBRF Gene

Protein Domains for CREBRF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUR6

UniProtKB/Swiss-Prot:

CRERF_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. CREBRF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. CREBRF subfamily.
genes like me logo Genes that share domains with CREBRF: view

No data available for Gene Families for CREBRF Gene

Function for CREBRF Gene

Molecular function for CREBRF Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum stress.

Phenotypes for CREBRF Gene

genes like me logo Genes that share phenotypes with CREBRF: view

Animal Model Products

CRISPR Products

miRNA for CREBRF Gene

miRTarBase miRNAs that target CREBRF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBRF Gene

Localization for CREBRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBRF Gene

Nucleus. Note=Colocalizes with CREB3 in nuclear foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREBRF Gene COMPARTMENTS Subcellular localization image for CREBRF gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18391022
genes like me logo Genes that share ontologies with CREBRF: view

Pathways & Interactions for CREBRF Gene

SuperPathways for CREBRF Gene

No Data Available

Interacting Proteins for CREBRF Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296953%0d%0a9606.ENSP00000342136%0d%0a9606.ENSP00000304903%0d%0a
Selected Interacting proteins: Q8IUR6-CRERF_HUMAN ENSP00000296953 for CREBRF Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for CREBRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18391022
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006810 transport IEA --
GO:0032388 positive regulation of intracellular transport IDA 18391022
genes like me logo Genes that share ontologies with CREBRF: view

No data available for Pathways by source and SIGNOR curated interactions for CREBRF Gene

Drugs & Compounds for CREBRF Gene

No Compound Related Data Available

Transcripts for CREBRF Gene

Unigene Clusters for CREBRF Gene

CREB3 regulatory factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREBRF Gene

No ASD Table

Relevant External Links for CREBRF Gene

GeneLoc Exon Structure for
CREBRF
ECgene alternative splicing isoforms for
CREBRF

Expression for CREBRF Gene

mRNA expression in normal human tissues for CREBRF Gene

mRNA differential expression in normal tissues according to GTEx for CREBRF Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CREBRF Gene

This gene is overexpressed in Liver, secretome (24.9), Platelet (8.9), and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CREBRF Gene



SOURCE GeneReport for Unigene cluster for CREBRF Gene Hs.484195

genes like me logo Genes that share expression patterns with CREBRF: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CREBRF Gene

Orthologs for CREBRF Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBRF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C20H5orf41 35
  • 93.95 (n)
  • 97.97 (a)
CREBRF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREBRF 35
  • 95.04 (n)
  • 98.44 (a)
CREBRF 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crebrf 35
  • 89.88 (n)
  • 93.9 (a)
Crebrf 16
Crebrf 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CREBRF 35
  • 99.9 (n)
  • 100 (a)
CREBRF 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crebrf 35
  • 90.51 (n)
  • 94.52 (a)
oppossum
(Monodelphis domestica)
Mammalia CREBRF 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREBRF 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves C13H5ORF41 35
  • 80.67 (n)
  • 86.53 (a)
C13H5ORF41 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBRF 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crebrf 35
  • 70.82 (n)
  • 77.32 (a)
zebrafish
(Danio rerio)
Actinopterygii crebrf 35
  • 70.48 (n)
  • 79.24 (a)
crebrf 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13624 36
  • 17 (a)
OneToOne
Species with no ortholog for CREBRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBRF Gene

ENSEMBL:
Gene Tree for CREBRF (if available)
TreeFam:
Gene Tree for CREBRF (if available)

Paralogs for CREBRF Gene

No data available for Paralogs for CREBRF Gene

Variants for CREBRF Gene

Sequence variations from dbSNP and Humsavar for CREBRF Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17854147 - 173,110,551(+) GGAGA(A/G)CTGAT reference, missense
rs2412 -- 173,082,506(-) CAAAC(C/T)GGACT intron-variant
rs29775 -- 173,056,020(+) GCAAA(A/C)GGACA upstream-variant-2KB
rs29776 -- 173,054,815(-) GGAAA(C/G)TAAAA upstream-variant-2KB
rs29777 -- 173,054,411(-) GCAGC(C/G)AGGTT upstream-variant-2KB

Variation tolerance for CREBRF Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREBRF Gene

HapMap Linkage Disequilibrium report
CREBRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CREBRF Gene

Disorders for CREBRF Gene

Relevant External Links for CREBRF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREBRF

No disorders were found for CREBRF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBRF Gene

Publications for CREBRF Gene

  1. A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PMID: 18391022) Audas T.E. … Lu R. (Mol. Cell. Biol. 2008) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. (PMID: 23071095) Martyn A.C. … Lu R. (Mol. Cell. Biol. 2012) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CREBRF Gene

Sources for CREBRF Gene

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