CREBRF Gene
protein-coding GIFtS: 39
GCID: GC05P172484
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CREB3 regulatory factor(Previous name: chromosome 5 open reading frame 41 )
(Previous symbol: C5orf41)
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Aliases
for CREBRF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CREB3 Regulatory Factor1 2 | | Adult Retina Protein2 | | C5orf411 2 3 | | Luman-Recruiting Factor2 | | LRF1 2 3 | | Luman/CREB3 Recruitment Factor2 | | Luman Recruitment Factor2 3 | | UPF0474 Protein C5orf412 | | Chromosome 5 Open Reading Frame 411 | | |
Export aliases for CREBRF gene to outside databases |
Summaries
for CREBRF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR).Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci
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Genomic Views
for CREBRF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CREBRF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CREBRF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBRF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.2CREBRF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P172484: view genomic region
(about GC identifiers)
Start:
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172,483,355 bp from pter |
End:
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172,566,291 bp from pter |
Size:
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82,937 bases |
Orientation:
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plus strand |
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Proteins
for CREBRF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6 (See
protein sequence)Recommended Name: CREB3 regulatory factor Size: 639 amino acids; 72149 Da
Subunit: Interacts (via leucine-zipper domain) with CREB3 (via leucine-zipper domain); the interaction promotes CREB3degradation
Subcellular location: Nucleus. Note=Colocalizes with CREB3 in nuclear foci
Sequence caution: Sequence=AC008378; Type=Erroneous gene model prediction;
Secondary accessions: B3DFH2 B3KW49 D3DQM2 F5GXN3 Q5HYG4 Q5HYK0 Q86YR3 Q8IZG1Alternative splicing: 3 isoforms: Q8IUR6-1 Q8IUR6-2 Q8IUR6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CREBRF: NX_Q8IUR6
Post-translational modifications:
Probably degraded by the proteasome1
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IUR6
CREBRF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001161865.1 NP_001161866.1 NP_705835.2
ENSEMBL proteins: ENSP00000431107 ENSP00000296953 ENSP00000428290 ENSP00000430801 ENSP00000440075
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CREBRF for ontologies About GeneDecksing
CREBRF Antibody Products:
Assay Products for CREBRF: |
Protein
Domains /
Families
for CREBRF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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CREBRF for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IUR6ProtoNet protein and cluster: Q8IUR6 UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6Similarity: Belongs to the bZIP family. CREBRF subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domain |
Function
for CREBRF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: CRERF_HUMAN, Q8IUR6Function: Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR).Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear fociInduction: Up-regulated by endoplasmic reticulum stress
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CREBRF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBRF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBRF |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 18391022 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
CREBRF for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CREBRF:
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Pathways & Interactions
for CREBRF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREBRF
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CREBRF (Q8IUR61, 3 ENSP000002969534) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
CREBRF for ontologies About GeneDecksing
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Drugs & Compounds
for CREBRF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CREBRF
Search CenterWatch for drugs/clinical trials and news about CREBRF / CRERF
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Transcripts
for CREBRF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for CREBRF gene (3 alternative transcripts): NM_001168393.1 NM_001168394.1 NM_153607.2 Unigene Cluster for CREBRF: CREB3 regulatory factor Hs.484195 [show with all ESTs]Unigene Representative Sequence: NM_1536077 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522692(uc003mcf.3 uc003mcg.3) ENST00000296953(uc011dfd.1)
ENST00000520420 ENST00000520464 ENST00000517882 ENST00000523161 ENST00000540014(uc003mch.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CREBRF | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREBRF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBRF |
Additional cDNA sequence: AK122675.1 AK124117.1 AK291677.1 AK297424.1 AK300043.1 AY139008.1 AY174896.1 AY635785.1 BC041709.1 BC043185.2 BX647768.1 9 DOTS entries: DT.91991182 DT.92052308 DT.451573 DT.95210676 DT.120813712 DT.405613 DT.65288542 DT.95272153 DT.92027438 24/169 AceView cDNA sequences (see all 169): BE465448 BF593533 AI436055 BM723244 AW770347 BM682460 AY174896 AA290875 AW342063 BX113013 BE465851 BM142654 AA243634 AI276414 NM_153607 N50563 AI796566 AW191975 N46919 AW148858 AA437223 AI307750 AI743558 BU736313
GeneLoc Exon Structure
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Expression
for CREBRF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CREBRF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTCTCAT
About this image
See CREBRF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREBRF
SOURCE GeneReport for Unigene cluster: Hs.484195
SABiosciences Custom PCR Arrays for CREBRF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBRF
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CREBRF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBRF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBRF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBRF |
Orthologs
for CREBRF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for CREBRF gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CREBRF (if available)
TreeFam Gene Tree for CREBRF (if available) |
Paralogs
for CREBRF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CREBRF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CREBRF (172483355 - 172566291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CREBRF: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBRF |
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Disorders
/ Diseases
for CREBRF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CREBRF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CREBRF gene integrated from 9 sources:
(articles sorted by number of sources associating them with CREBRF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. (PubMed id 18391022)1, 2, 3 Audas T.E.... Lu R. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Luman/CREB3 recruitment factor regulates glucocorticoi d receptor activity and is essential for prolactin-mediated maternal instinct. (PubMed id 23071095)1 Martyn A.C....Lu R. (2012)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CREBRF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CREBRF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CREBRF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CREBRF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CREBRF | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CREBRF gene:
Search GeneIP for patents involving CREBRF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CREBRF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CREBRF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREBRF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBRF | | | OriGene Protein Over-expression Lysate for CREBRF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CREBRF | | OriGene 3'-UTR Clone for CREBRF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBRF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREBRF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBRF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBRF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREBRF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBRF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBRF |
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| | | | Search Tocris compounds for CREBRF |
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 | | | CREBRF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBRF |
|  |  |  | | | | Search ThermoFisher Antibodies for CREBRF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBRF |
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