Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREBL2 Gene

Aliases for CREBL2 Gene

  • CAMP Responsive Element Binding Protein-Like 2 2 3

External Ids for CREBL2 Gene

Previous GeneCards Identifiers for CREBL2 Gene

  • GC12P012491
  • GC12P012909
  • GC12P012665
  • GC12P012656
  • GC12P012764
  • GC12P012529

Summaries for CREBL2 Gene

Entrez Gene Summary for CREBL2 Gene

  • cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREBL2 Gene

CREBL2 (CAMP Responsive Element Binding Protein-Like 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBL2 Gene

  • Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBL2 Gene

Genomics for CREBL2 Gene

Regulatory Elements for CREBL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CREBL2 Gene

Start:
12,611,827 bp from pter
End:
12,645,108 bp from pter
Size:
33,282 bases
Orientation:
Plus strand

Genomic View for CREBL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBL2 Gene

Proteins for CREBL2 Gene

  • Protein details for CREBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60519-CRBL2_HUMAN
    Recommended name:
    cAMP-responsive element-binding protein-like 2
    Protein Accession:
    O60519
    Secondary Accessions:
    • B5BUM5

    Protein attributes for CREBL2 Gene

    Size:
    120 amino acids
    Molecular mass:
    13784 Da
    Quaternary structure:
    • Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.

neXtProt entry for CREBL2 Gene

Proteomics data for CREBL2 Gene at MOPED

Post-translational modifications for CREBL2 Gene

Other Protein References for CREBL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREBL2 Gene

Domains for CREBL2 Gene

Gene Families for CREBL2 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CREBL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60519

UniProtKB/Swiss-Prot:

CRBL2_HUMAN :
  • O60519
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREBL2: view

Function for CREBL2 Gene

Molecular function for CREBL2 Gene

GENATLAS Biochemistry: cAMP response element binding protein-like 2
UniProtKB/Swiss-Prot Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for CREBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREBL2: view
genes like me logo Genes that share phenotypes with CREBL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREBL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CREBL2 Gene

Localization for CREBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREBL2 Gene COMPARTMENTS Subcellular localization image for CREBL2 gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CREBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with CREBL2: view

Pathways for CREBL2 Gene

SuperPathways for CREBL2 Gene

No Data Available

Interacting Proteins for CREBL2 Gene

Gene Ontology (GO) - Biological Process for CREBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction TAS 9693048
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CREBL2: view

No data available for Pathways by source for CREBL2 Gene

Transcripts for CREBL2 Gene

mRNA/cDNA for CREBL2 Gene

Unigene Clusters for CREBL2 Gene

CAMP responsive element binding protein-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREBL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREBL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for CREBL2 Gene

GeneLoc Exon Structure for
CREBL2
ECgene alternative splicing isoforms for
CREBL2

Expression for CREBL2 Gene

mRNA expression in normal human tissues for CREBL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CREBL2 Gene

SOURCE GeneReport for Unigene cluster for CREBL2 Gene Hs.591156

genes like me logo Genes that share expressions with CREBL2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREBL2 Gene

Orthologs for CREBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBL2 35
  • 99.72 (n)
  • 100 (a)
CREBL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREBL2 35
  • 92.5 (n)
  • 98.33 (a)
CREBL2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREBL2 35
  • 94.17 (n)
  • 99.17 (a)
CREBL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crebl2 35
  • 89.64 (n)
  • 94.12 (a)
Crebl2 16
Crebl2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CREBL2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crebl2 35
  • 91.04 (n)
  • 97.48 (a)
chicken
(Gallus gallus)
Aves CREBL2 35
  • 82.91 (n)
  • 92.44 (a)
CREBL2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBL2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crebl2 35
  • 73.51 (n)
  • 87.5 (a)
zebrafish
(Danio rerio)
Actinopterygii crebl2 35
  • 72.65 (n)
  • 82.91 (a)
crebl2 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008762 35
  • 59.67 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18619 35
  • 60.49 (n)
  • 65.43 (a)
CG18619 36
  • 49 (a)
OneToOne
Species with no ortholog for CREBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBL2 Gene

ENSEMBL:
Gene Tree for CREBL2 (if available)
TreeFam:
Gene Tree for CREBL2 (if available)

Paralogs for CREBL2 Gene

No data available for Paralogs for CREBL2 Gene

Variants for CREBL2 Gene

Sequence variations from dbSNP and Humsavar for CREBL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4555 -- 12,643,938(-) GCAAC(A/G)TAAAG utr-variant-3-prime
rs9531 -- 12,644,217(+) TTGGA(C/G)GAGAT utr-variant-3-prime
rs12236 -- 12,644,842(+) CTTGA(C/G)TTAAA utr-variant-3-prime
rs15597 -- 12,644,669(-) ATAAT(A/G)GAAAG utr-variant-3-prime
rs759743 -- 12,612,122(-) TCCCC(C/G)GGCTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CREBL2 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
dgv479e1 CNV Complex 17122850
nsv898811 CNV Gain 21882294
nsv612 CNV Insertion 18451855
nsv509456 CNV Insertion 20534489

Relevant External Links for CREBL2 Gene

HapMap Linkage Disequilibrium report
CREBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBL2 Gene

Disorders for CREBL2 Gene

Relevant External Links for CREBL2

Genetic Association Database (GAD)
CREBL2
Human Genome Epidemiology (HuGE) Navigator
CREBL2
genes like me logo Genes that share disorders with CREBL2: view

No data available for UniProtKB/Swiss-Prot for CREBL2 Gene

Publications for CREBL2 Gene

  1. CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B. (PMID: 9693048) Hoornaert I. … Baens M. (Genomics 1998) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for CREBL2 Gene

Sources for CREBL2 Gene

Back to Top

Content