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Aliases for CREBL2 Gene

Aliases for CREBL2 Gene

  • CAMP Responsive Element Binding Protein Like 2 2 3
  • CAMP Responsive Element Binding Protein-Like 2 2 5

External Ids for CREBL2 Gene

Previous GeneCards Identifiers for CREBL2 Gene

  • GC12P012491
  • GC12P012909
  • GC12P012665
  • GC12P012656
  • GC12P012764
  • GC12P012529

Summaries for CREBL2 Gene

Entrez Gene Summary for CREBL2 Gene

  • cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREBL2 Gene

CREBL2 (CAMP Responsive Element Binding Protein Like 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CREBL2 Gene

  • Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREBL2 Gene

Genomics for CREBL2 Gene

Regulatory Elements for CREBL2 Gene

Promoters for CREBL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CREBL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CREBL2 Gene

Chromosome:
12
Start:
12,611,827 bp from pter
End:
12,645,108 bp from pter
Size:
33,282 bases
Orientation:
Plus strand

Genomic View for CREBL2 Gene

Genes around CREBL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREBL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREBL2 Gene

Proteins for CREBL2 Gene

  • Protein details for CREBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60519-CRBL2_HUMAN
    Recommended name:
    cAMP-responsive element-binding protein-like 2
    Protein Accession:
    O60519
    Secondary Accessions:
    • B5BUM5

    Protein attributes for CREBL2 Gene

    Size:
    120 amino acids
    Molecular mass:
    13784 Da
    Quaternary structure:
    • Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.

neXtProt entry for CREBL2 Gene

Proteomics data for CREBL2 Gene at MOPED

Post-translational modifications for CREBL2 Gene

Other Protein References for CREBL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREBL2 Gene

Domains & Families for CREBL2 Gene

Gene Families for CREBL2 Gene

Protein Domains for CREBL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60519

UniProtKB/Swiss-Prot:

CRBL2_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREBL2: view

Function for CREBL2 Gene

Molecular function for CREBL2 Gene

GENATLAS Biochemistry:
cAMP response element binding protein-like 2
UniProtKB/Swiss-Prot Function:
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor.
genes like me logo Genes that share phenotypes with CREBL2: view

Animal Model Products

miRNA for CREBL2 Gene

miRTarBase miRNAs that target CREBL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREBL2 Gene

Localization for CREBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREBL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREBL2 Gene COMPARTMENTS Subcellular localization image for CREBL2 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CREBL2 Gene

Pathways & Interactions for CREBL2 Gene

SuperPathways for CREBL2 Gene

No Data Available

Interacting Proteins for CREBL2 Gene

Gene Ontology (GO) - Biological Process for CREBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0033138 positive regulation of peptidyl-serine phosphorylation ISS --
GO:0045600 positive regulation of fat cell differentiation ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CREBL2: view

No data available for Pathways by source and SIGNOR curated interactions for CREBL2 Gene

Drugs & Compounds for CREBL2 Gene

No Compound Related Data Available

Transcripts for CREBL2 Gene

mRNA/cDNA for CREBL2 Gene

Unigene Clusters for CREBL2 Gene

CAMP responsive element binding protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREBL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for CREBL2 Gene

GeneLoc Exon Structure for
CREBL2
ECgene alternative splicing isoforms for
CREBL2

Expression for CREBL2 Gene

mRNA expression in normal human tissues for CREBL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CREBL2 Gene

This gene is overexpressed in Ovary (43.7) and CD4 Tcells (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CREBL2 Gene



SOURCE GeneReport for Unigene cluster for CREBL2 Gene Hs.591156

genes like me logo Genes that share expression patterns with CREBL2: view

Protein tissue co-expression partners for CREBL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREBL2 Gene

Orthologs for CREBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREBL2 36
  • 100 (a)
OneToOne
CREBL2 35
  • 99.72 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CREBL2 35
  • 92.5 (n)
  • 98.33 (a)
CREBL2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREBL2 36
  • 99 (a)
OneToOne
CREBL2 35
  • 94.17 (n)
  • 99.17 (a)
mouse
(Mus musculus)
Mammalia Crebl2 16
Crebl2 36
  • 91 (a)
OneToOne
Crebl2 35
  • 89.64 (n)
  • 94.12 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CREBL2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crebl2 35
  • 91.04 (n)
  • 97.48 (a)
chicken
(Gallus gallus)
Aves CREBL2 35
  • 82.91 (n)
  • 92.44 (a)
CREBL2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREBL2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crebl2 35
  • 73.51 (n)
  • 87.5 (a)
zebrafish
(Danio rerio)
Actinopterygii crebl2 35
  • 72.65 (n)
  • 82.91 (a)
crebl2 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008762 35
  • 59.67 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18619 35
  • 60.49 (n)
  • 65.43 (a)
CG18619 36
  • 49 (a)
OneToOne
Species with no ortholog for CREBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREBL2 Gene

ENSEMBL:
Gene Tree for CREBL2 (if available)
TreeFam:
Gene Tree for CREBL2 (if available)

Paralogs for CREBL2 Gene

No data available for Paralogs for CREBL2 Gene

Variants for CREBL2 Gene

Sequence variations from dbSNP and Humsavar for CREBL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2417218 -- 12,641,605(+) cgccc(A/G)TCTAG intron-variant
rs2111940 -- 12,616,015(-) GTTAA(C/T)ATTTA intron-variant
rs4763855 -- 12,614,824(+) TCTTC(A/C)AGTTT intron-variant
rs4763858 -- 12,624,039(+) ACTGC(C/T)CCAGT intron-variant
rs4763859 -- 12,634,071(+) ATAGT(A/G)TATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREBL2 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
dgv479e1 CNV Complex 17122850
nsv898811 CNV Gain 21882294
nsv612 CNV Insertion 18451855
nsv509456 CNV Insertion 20534489

Variation tolerance for CREBL2 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREBL2 Gene

HapMap Linkage Disequilibrium report
CREBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREBL2 Gene

Disorders for CREBL2 Gene

Relevant External Links for CREBL2

Genetic Association Database (GAD)
CREBL2
Human Genome Epidemiology (HuGE) Navigator
CREBL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREBL2

No disorders were found for CREBL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREBL2 Gene

Publications for CREBL2 Gene

  1. CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B. (PMID: 9693048) Hoornaert I. … Baens M. (Genomics 1998) 2 3 4 67
  2. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PMID: 23273568) Yang W. … Lau Y.L. (Am. J. Hum. Genet. 2013) 3
  3. Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia. (PMID: 23077088) Al-Shehhi H. … Moorman A.V. (Genes Chromosomes Cancer 2013) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy K.W. … Pang C.P. (Physiol. Genomics 2006) 3

Products for CREBL2 Gene

Sources for CREBL2 Gene

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