CREBL2 Gene
protein-coding GIFtS: 49
GCID: GC12P012764
|
|
cAMP responsive element binding protein-like 2
| |
Aliases
for CREBL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CAMP Responsive Element Binding Protein-Like 21 2 | | CAMP-Responsive Element-Binding Protein-Like 22 | | MHBs-Binding Protein 12 |
Export aliases for CREBL2 gene to outside databasesPrevious GC identifers: GC12P012491 GC12P012909 GC12P012665 GC12P012656 GC12P012529 |
Summaries
for CREBL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CREBL2:
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonlydeleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoieticmalignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity withCRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consistsof about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved inprotein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance ofCREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. Mayalso play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in variouscancers suggests that it might act as a tumor suppressor
|
Genomic Views
for CREBL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CREBL2 gene promoter:
CREB RP58 deltaCREB MyoD Meis-1a Meis-1b Meis-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for CREBL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2CREBL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P012764: view genomic region
(about GC identifiers)
Start:
|
12,764,761 bp from pter |
End:
|
12,798,042 bp from pter |
Size:
|
33,282 bases |
Orientation:
|
plus strand |
|
Proteins
for CREBL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519 (See
protein sequence)Recommended Name: cAMP-responsive element-binding protein-like 2 Size: 120 amino acids; 13784 Da
Subunit: Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: B5BUM5Explore the universe of human proteins at neXtProt for CREBL2: NX_O60519
Post-translational modifications:
Phosphorylated by AMPK1
View neXtProt modification sites for NX_O60519
CREBL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001301.1
ENSEMBL proteins: ENSP00000228865
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
CREBL2 for ontologies About GeneDecksing
CREBL2 Antibody Products:
Assay Products for CREBL2: |
Protein
Domains /
Families
for CREBL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CREBL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60519ProtoNet protein and cluster: O60519 UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519Similarity: Belongs to the bZIP family. ATF subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domain |
Function
for CREBL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. Mayalso play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in variouscancers suggests that it might act as a tumor suppressor Genatlas biochemistry entry for CREBL2:cAMP response element binding protein-like 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CREBL2 (NM_001310) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREBL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBL2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
-- | -- |
CREBL2 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for CREBL2:
|
Pathways & Interactions
for CREBL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREBL2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CREBL2 (ENSP000002288654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
CREBL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CREBL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CREBL2
Search CenterWatch for drugs/clinical trials and news about CREBL2 / CRBL2
|
Transcripts
for CREBL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CREBL2 gene: NM_001310.2 Unigene Cluster for CREBL2: CAMP responsive element binding protein-like 2 Hs.591156 [show with all ESTs]Unigene Representative Sequence: BC1060522 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540224 ENST00000228865(uc001rap.1 uc009zhv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CREBL2 (NM_001310) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREBL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBL2 |
Additional cDNA sequence: AB451461.1 AF039081.1 AK002189.1 AK307202.1 BC104873.1 BC106052.1 BC112157.1 CR542250.1 DQ307498.1 9 DOTS entries: DT.456032 DT.100706262 DT.92440621 DT.92440622 DT.99977014 DT.100809589 DT.121210655 DT.121210688 DT.91832120 24/298 AceView cDNA sequences (see all 298): AF039081 AI571134 BE768391 BQ772292 AA232699 BM706182 AA132808 BM552607 F11103 AA441892 CD742652 AK002189 CR542250 AI638053 AI216838 AA939090 F13405 H88170 CD244319 BU173025 AA758170 BG010274 BU161059 W81578
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CREBL2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | - | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for CREBL2
|
Expression
for CREBL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CREBL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAATAAATG
About this image
See CREBL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREBL2
SOURCE GeneReport for Unigene cluster: Hs.591156
SABiosciences Custom PCR Arrays for CREBL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CREBL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBL2 |
Orthologs
for CREBL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CREBL2 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CREBL2 (if available)
TreeFam Gene Tree for CREBL2 (if available) |
Paralogs
for CREBL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CREBL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CREBL2 (12764761 - 12798042 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CREBL2
1 CNV: 3876 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBL2 |
|
Disorders
/ Diseases
for CREBL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CREBL2 for disorders About GeneDecksing
OMIM gene information: 603476
OMIM disorders: --
7  diseases for CREBL2: About MalaCardsovarian cancer acute lymphoblastic leukemia lymphoblastic leukemia acute myeloid leukemia
myeloid leukemia myelodysplastic syndrome leukemia
Human Genome Epidemiology (HuGE) Navigator: CREBL2 (1 document)
Export disorders for CREBL2 gene to outside databases
|
Publications
for CREBL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CREBL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CREBL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B. (PubMed id 9693048)1, 2, 3 Hoornaert I.... Baens M. (1998)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- AMP-activated protein kinase phosphorylates transcription factors of the CREB family. (PubMed id 18063805)2 Thomson D.M.... Winder W.W. (2008)
- Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (2008)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. (PubMed id 9171997)1 Andreasson P....Hoglund M. (1997)
- Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case. (PubMed id 8653712)1 Wlodarska I....Van den Berghe H. (1996)
|
External Searches for CREBL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CREBL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CREBL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CREBL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CREBL2 gene:
Search GeneIP for patents involving CREBL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CREBL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CREBL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREBL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CREBL2 | | | OriGene Protein Over-expression Lysate for CREBL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CREBL2 | | OriGene 3'-UTR Clone for CREBL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREBL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CREBL2 | | OriGene Custom Protein Services for CREBL2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CREBL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREBL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREBL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREBL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CREBL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CREBL2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CREBL2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CREBL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREBL2 |
|  |  |  | | | | ThermoFisher Antibodies for CREBL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREBL2 |
|
|
|
|
