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CREBL2 Gene

protein-coding   GIFtS: 50
GCID: GC12P012764

CAMP Responsive Element Binding Protein-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CAMP Responsive Element Binding Protein-Like 21 2
CAMP-Responsive Element-Binding Protein-Like 22
MHBs-Binding Protein 12

External Ids:    HGNC: 23501   Entrez Gene: 13892   Ensembl: ENSG000001112697   OMIM: 6034765   UniProtKB: O605193   
ORGUL members:         

Export aliases for CREBL2 gene to outside databases

Previous GC identifers: GC12P012491 GC12P012909 GC12P012665 GC12P012656 GC12P012529


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREBL2 Gene:
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly
deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic
malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with
CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain
consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper
motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding
capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREBL2 Gene:
CREBL2 (cAMP responsive element binding protein-like 2) is a protein-coding gene. Diseases associated with CREBL2 include ovarian cancer, and myelodysplastic syndromes. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519
Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation.
May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in
various cancers suggests that it might act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREBL2 gene promoter:
         CREB   RP58   deltaCREB   MyoD   Meis-1a   Meis-1b   Meis-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREBL2 promoter sequence
   Search Chromatin IP Primers for CREBL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREBL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

CREBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREBL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P012764:  view genomic region     (about GC identifiers)

Start:
12,764,761 bp from pter      End:
12,798,042 bp from pter
Size:
33,282 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519 (See protein sequence)
Recommended Name: cAMP-responsive element-binding protein-like 2  
Size: 120 amino acids; 13784 Da
Subunit: Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity (By
similarity)
Secondary accessions: B5BUM5

Explore the universe of human proteins at neXtProt for CREBL2: NX_O60519

Explore proteomics data for CREBL2 at MOPED

Post-translational modifications: 

  • Phosphorylated by AMPK1
  • Modification sites at neXtProt

  • See CREBL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001301.1  
    ENSEMBL proteins: 
     ENSP00000228865  

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    Cloud-Clone Corp. CLIAs for CREBL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry O60519

    ProtoNet protein and cluster: O60519

    UniProtKB/Swiss-Prot: CRBL2_HUMAN, O60519
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREBL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRBL2_HUMAN, O60519
    Function: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation.
    May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in
    various cancers suggests that it might act as a tumor suppressor

         Genatlas biochemistry entry for CREBL2:
    cAMP response element binding protein-like 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    CREBL2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CREBL2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     Increased 8N DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREBL2
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CREBL2:
    hsa-mir-215-5p (MIRT024903), hsa-mir-19b-3p (MIRT031269), hsa-mir-18a-5p (MIRT031360), hsa-mir-15a-5p (MIRT000833), hsa-mir-16-5p (MIRT000832), hsa-mir-192-5p (MIRT026935)

    Block miRNA regulation of human, mouse, rat CREBL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREBL2 (see all 66):
    hsa-miR-578 hsa-miR-149 hsa-miR-29a* hsa-miR-200b hsa-miR-761 hsa-miR-374b* hsa-miR-1206 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidCREBL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CREBL2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRBL2_HUMAN, O60519: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    CREBL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREBL2
    Interactions:

        Search GeneGlobe Interaction Network for CREBL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CREBL2 (ENSP000002288654) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC7ENSP000002958994STRING: ENSP00000295899
    CREB1ENSP000003876994STRING: ENSP00000387699
    CREMENSP000002653724STRING: ENSP00000265372
    GTSF1ENSP000003041854STRING: ENSP00000304185
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS9693048
    GO:0030154cell differentiation IEA--

    CREBL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREBL2 (CRBL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CREBL2 gene: 
    NM_001310.3  

    Unigene Cluster for CREBL2:

    CAMP responsive element binding protein-like 2
    Hs.591156  [show with all ESTs]
    Unigene Representative Sequence: BC106052
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540224 ENST00000228865(uc001rap.1 uc009zhv.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat CREBL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREBL2 (see all 66):
    hsa-miR-578 hsa-miR-149 hsa-miR-29a* hsa-miR-200b hsa-miR-761 hsa-miR-374b* hsa-miR-1206 hsa-miR-27a
    SwitchGear 3'UTR luciferase reporter plasmidCREBL2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CREBL2
    Predesigned siRNA for gene silencing in human, mouse, rat CREBL2
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    OriGene qPCR primer pairs and template standards for CREBL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CREBL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREBL2
      QuantiTect SYBR Green Assays in human, mouse, rat CREBL2
      QuantiFast Probe-based Assays in human, mouse, rat CREBL2

    Additional mRNA sequence: 

    AB451461.1 AF039081.1 AK002189.1 AK307202.1 BC104873.1 BC106052.1 BC112157.1 CR542250.1 
    DQ307498.1 

    10 DOTS entries:

    DT.456032  DT.100706262  DT.92440621  DT.92440622  DT.99977014  DT.100809589  DT.121210655  DT.121210688 
    DT.91832120  DT.95115949 

    Selected AceView cDNA sequences (see all 298):

    BU161059 AK002189 BM992088 AA441892 CR542250 CD742792 AA132808 BQ772292 
    AU131473 AU130592 AA758170 AI867434 H87995 AV647072 BM552607 AA232699 
    BM682120 AA976073 AU139381 CR612195 F11103 BQ229715 BE768391 BM700084 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CREBL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
    SP1:        -                     
    SP2:                              


    ECgene alternative splicing isoforms for CREBL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREBL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAATAAATG
    CREBL2 Expression
    About this image


    CREBL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Adrenal Gland (Endocrine System)
    CREBL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREBL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591156
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREBL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crebl21 , 5 cAMP responsive element binding protein-like 21, 5 89.64(n)1
    94.12(a)1
      6 (65.77 cM)5
    2324301  NM_177687.31  NP_808355.11 
     1348301545 
    chicken
    (Gallus gallus)
    Aves CREBL21 cAMP responsive element binding protein-like 2 82.91(n)
    92.44(a)
      426496  NM_001278110.1  NP_001265039.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREBL26
    cAMP responsive element binding protein-like 2
    88(a)
    1 ↔ 1
    GL343579.1(451236-461913)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia crebl21 cAMP responsive element binding protein-like 2 73.51(n)
    87.5(a)
      100038265  NM_001097383.1  NP_001090852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crebl21 cAMP responsive element binding protein-like 2 72.65(n)
    82.91(a)
      436975  NM_001002702.2  NP_001002702.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG186191 CG18619 60.49(n)
    65.43(a)
      34371  NM_135519.2  NP_609363.1 


    ENSEMBL Gene Tree for CREBL2 (if available)
    TreeFam Gene Tree for CREBL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREBL2 (see all 672)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47638541,2
    C,H--12527655(+) TAGATC/AATTTT 1 -- us2k112Minor allele frequency- A:0.01NA WA CSA EA 374
    rs1382961271,2
    --12527809(+) GCTGGA/GATTAC 1 -- us2k10--------
    rs1862935931,2
    --12527990(+) TTTTCA/CTCACC 1 -- us2k10--------
    rs1440946141,2
    --12528030(+) TCACTC/GTCCTT 1 -- us2k10--------
    rs1473137771,2
    --12528057(+) CCCTGC/TCATTC 1 -- us2k10--------
    rs1914822801,2
    --12528360(+) CAAACA/GATCCT 1 -- us2k10--------
    rs1449961891,2
    C--12528461(+) TTTAA-/TTTTTT 1 -- us2k10--------
    rs71335231,2
    C,F,A,H--12528479(+) GACTGA/CATCTT 1 -- us2k115Minor allele frequency- C:0.14NS EA NA WA CSA 790
    rs1833224721,2
    --12528494(+) TATGGA/GTCTTC 1 -- us2k10--------
    rs1504155921,2
    C--12528504(+) CTTCC-/TT    
       CTTCT
    TTCTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREBL2 (12764761 - 12798042 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CREBL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745567CNV Deletion23290073
    nsv612CNV Insertion18451855
    nsv509456CNV Insertion20534489
    nsv898811CNV Gain21882294
    dgv479e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603476    OMIM disorders: --

    11 diseases for CREBL2:    
    About MalaCards
    ovarian cancer    myelodysplastic syndromes    acute myeloid leukemia    lymphoblastic leukemia
    myeloid leukemia    leukemia    asthma    systemic lupus erythematosus
    lupus erythematosus    malaria    endotheliitis


    CREBL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CREBL2
    Human Genome Epidemiology (HuGE) Navigator: CREBL2 (1 document)

    Export disorders for CREBL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREBL2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CREBL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B. (PubMed id 9693048)1, 2, 3 Hoornaert I.... Baens M. (Genomics 1998)
    2. Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia. (PubMed id 23077088)1 Al-Shehhi H....Moorman A.V. (amp 2013)
    3. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (Am. J. Hum. Genet. 2013)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    5. AMP-activated protein kinase phosphorylates transcription factors of the CREB family. (PubMed id 18063805)2 Thomson D.M.... Winder W.W. (J. Appl. Physiol. 2008)
    6. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (PubMed id 18617639)4 Litonjua A.A....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2008)
    7. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (Nat. Methods 2008)
    8. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (Physiol. Genomics 2006)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1389 HGNC: 2350 AceView: CREBL2 Ensembl:ENSG00000111269 euGenes: HUgn1389
    ECgene: CREBL2 H-InvDB: CREBL2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREBL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CREBL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREBL2 gene:
    Search GeneIP for patents involving CREBL2

    GeneCards and IP:
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