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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CREB5 Gene

protein-coding   GIFtS: 54
GCID: GC07P028305

cAMP responsive element binding protein 5
 Explore 7 diseases affiliated with
CREB5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CREB5    

Aliases
for CREB5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CAMP Responsive Element Binding Protein 51 2     CAMP Response Element-Binding Protein CRE-BPa2
CRE-BPA1 2     CAMP Responsive Element Binding Protein 5 Isoform Alpha2
H_GS165L15.11 2     Cyclic AMP-Responsive Element-Binding Protein 52
CREB-52 3     CRE-BPa3
CAMP-Responsive Element-Binding Protein 52 3     CREBPA3
CAMP Response Element Binding Protein CRE-Bpa2     

External Ids:    HGNC: 168441   Entrez Gene: 95862   Ensembl: ENSG000001465927   UniProtKB: Q029303   

Export aliases for CREB5 gene to outside databases

Previous GC identifers: GC07P028047 GC07P028194 GC07P028081 GC07P028112


Summaries
for CREB5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CREB5:
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family
contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a
heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript
variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
Function: Binds to the cAMP response element and activates transcription

Gene Wiki entry for CREB5


Genomic Views
for CREB5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREB5 gene promoter:
         E2F-4   E2F-3a   E2F-5   RP58   E2F-2   IRF-2   POU2F1   E2F   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CREB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CREB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p15.1   HGNC cytogenetic band: 7p15

CREB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P028305:  view genomic region     (about GC identifiers)

Start:
 28,338,940 bp from pter      End:
 28,865,511 bp from pter
Size:
 526,572 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 28,389,121-28,915,762     

Proteins
for CREB5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 5  
Size: 508 amino acids; 56918 Da
Subunit: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1
Subcellular location: Nucleus (Probable)
Secondary accessions: A8KA51 B4DU13 B5BUH3 C9JK47 Q05886 Q06246 Q75N02 Q86UJ9
Alternative splicing: 4 isoforms:  Q02930-1   Q02930-2   Q02930-3   Q02930-4   

Explore the universe of human proteins at neXtProt for CREB5: NX_Q02930

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02930

    • CREB5 Protein expression data from MOPED and PaxDb:    About this image 
    CREB5 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001011666.1  NP_004895.2  NP_878901.2  NP_878902.2  

    ENSEMBL proteins: 
     ENSP00000379593   ENSP00000394088   ENSP00000350359   ENSP00000379594   ENSP00000387197  
     ENSP00000394979   ENSP00000379592   ENSP00000440429  

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    Novus Biologicals CREB5 Proteins
    Novus Biologicals CREB5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CREB5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IC8378084

    CREB5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CREB5

    Protein Domains /
    Families
    for CREB5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CREB5 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004827 bZIP
     IPR015880 Znf_C2H2-like
     IPR016378 TF_cAMP-dep
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02930

    ProtoNet protein and cluster: Q02930

    1 Blocks protein family: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 C2H2-type zinc finger


    Function
    for CREB5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREB5_HUMAN, Q02930
    Function: Binds to the cAMP response element and activates transcription

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA8378084
    GO:0005515protein binding IPI8440710
    GO:0008270zinc ion binding IEA--
         
    CREB5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CREB5:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Creb5):
     adipose tissue  behavior/neurological  cellular  growth/size  homeostasis/metabolism 
     integument  mortality/aging 

    CREB5 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Creb5tm1Sis for CREB5
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CREB5 

    miRNA
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    8/198 QIAGEN miScript miRNA Assays for microRNAs that regulate CREB5 (see all 198):
    hsa-miR-124* hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-149 hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREB5 (see all 6)
    OriGene shRNA RFP: CREB5
    OriGene siRNA: CREB5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREB5
    Sirion Biotech Custom design and validation of potent shRNA sequences against CREB5 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CREB5 
    Sirion Biotech Customized adenovirus for potent knockdown of CREB5

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB5 

    Cell Line
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    Search LifeMap BioReagents cell lines for CREB5
    Sirion Biotech Customized stable knockdown cell line services for CREB5 
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB5


    Pathways & Interactions
    for CREB5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Vasopressin-regulated water reabsorption
    		Vasopressin-regulated water reabsorption1.00
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Huntington's disease0.40
    3Glioma
    		Prostate cancer0.39
    4Development Angiotensin activation of ERK
    		Cholinergic synapse0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    4         Kegg Pathways  (Kegg details for CREB5):
        Cholinergic synapse
    Vasopressin-regulated water reabsorption
    Huntington's disease
    Prostate cancer


    CREB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for CREB5 (Q029303 ENSP000003503594) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    ATF2P153363, ENSP000002641104I2D: score=1 STRING: ENSP00000264110
    KRTAP5-9P263713I2D: score=1 
    LGALS13Q9UHV83I2D: score=1 
    CREBBPENSP000002623674STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS8378084
    GO:0045444fat cell differentiation IEA--
    GO:0045893positive regulation of transcription, DNA-dependent IDA8378084
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----
    GO:0060612adipose tissue development IEA--

    CREB5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CREB5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CREB5

    1 HMDB Compound for CREB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Search CenterWatch for drugs/clinical trials and news about CREB5 

    Transcripts
    for CREB5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CREB5 gene (4 alternative transcripts): 
    NM_001011666.1  NM_004904.2  NM_182898.2  NM_182899.3  

    Unigene Cluster for CREB5:

    CAMP responsive element binding protein 5
    Hs.437075  [show with all ESTs]
    Unigene Representative Sequence: NM_182898
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396299 ENST00000469531 ENST00000478078 ENST00000482692(uc003szp.3)
    ENST00000424599 ENST00000357727(uc003szo.3 uc003szq.3 uc003szr.3 uc003szs.3)
    ENST00000396300 ENST00000409603 ENST00000461921 ENST00000426500 ENST00000396298
    ENST00000468391(uc011jzr.2) ENST00000484383 ENST00000468813 ENST00000498316


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
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    8/198 QIAGEN miScript miRNA Assays for microRNAs that regulate CREB5 (see all 198):
    hsa-miR-124* hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-149 hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CREB5 (see all 6)
    OriGene shRNA RFP: CREB5
    OriGene siRNA: CREB5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CREB5
    Sirion Biotech Custom design and validation of potent shRNA sequences against CREB5 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREB5 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREB5 (see all 4)
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    Primer
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    Additional cDNA sequence: 

    AB209262.1 AB451409.1 AK021493.1 AK057151.1 AK292916.1 AK298121.1 AK300455.1 AK316187.1 
    BC059400.1 L05515.1 L05911.1 L05912.1 L05913.1 

    13 DOTS entries:

    DT.91750301  DT.100812990  DT.95374150  DT.100812991  DT.97828917  DT.87014787  DT.95209779  DT.97825503 
    DT.100747131  DT.121057538  DT.95225955  DT.438809  DT.91828944 

    24/78 AceView cDNA sequences (see all 78):

    AA700776 CB149302 AV754746 BM468660 AL706583 AL706571 CK820213 BP345509 
    BX279704 AA581655 BC059400 AA582287 L05911 AU117379 NM_182898 BX107718 
    AW151127 AW024551 AW665405 AU119216 AJ710805 AI689210 BQ023803 AL698655 

    GeneLoc Exon Structure


    Expression
    for CREB5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CREB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CREB5 Expression
    About this image

    CREB5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    CartilageLumbar Intervertebral DiscCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See CREB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CREB5

    SOURCE GeneReport for Unigene cluster: Hs.437075
        SABiosciences Custom PCR Arrays for CREB5
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB5

    Orthologs
    for CREB5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CREB5 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CREB51 cAMP responsive element binding protein 5 86.06(n)
    94.67(a)    		   428435  XM_425995.3  XP_425995.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343275.1(364116-383884)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5659101 cyclic AMP-responsive element-binding protein 5-like 72.18(n)
    79.13(a)    		   565910  XM_001921055.1  XP_001921090.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 20(a)
    		 1 → many
    		 Group13.2(464747-466871)


    ENSEMBL Gene Tree for CREB5 (if available)
    TreeFam Gene Tree for CREB5 (if available) 

    Paralogs
    for CREB5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CREB5 gene
    ENSG000002672812  ATF72  ATF22  
    3 SIMAP similar genes for CREB5 using alignment to 5 protein entries:     CREB5_HUMAN (see all proteins):
    ATF2    ATF7    ATF3

    CREB5 for paralogs           About GeneDecksing



    Genomic Variants
    for CREB5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9678 NCBI SNPs in CREB5 are shown (see all 9678)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135528611,2
    		C--28336976(+) ACAGAC/GAGTAA 1 -- us2k12Minor allele frequency- G:0.03NA 122
    rs1426347451,2
    		--28336979(+) GACAGG/TAAGTG 1 -- us2k10--------
    rs1871351851,2
    		--28336983(+) GTAAGG/TGGTAG 1 -- us2k10--------
    rs1923593641,2
    		--28337040(+) TCCCAC/TTGTGT 1 -- us2k10--------
    rs1833206691,2
    		--28337410(+) ATCAAC/TGCTTG 1 -- us2k10--------
    rs1870024291,2
    		--28337756(+) TAAACA/GAGTGC 1 -- us2k10--------
    rs1502814031,2
    		--28337760(+) CGAGTA/GCCATG 1 -- us2k10--------
    rs1458046591,2
    		--28337804(+) GTATTA/CAGCCC 1 -- us2k10--------
    rs1489879221,2
    		--28337943(+) GGAACA/CTACAT 1 -- us2k10--------
    rs1907959121,2
    		--28337976(+) TCATAC/TTGAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREB5 (28338940 - 28588940 bp, first 250kb of CREB5)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CREB5
         3 CNVs: 64788 4529 99904
         3 Indels: 69839 43207 47332

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    Disorders / Diseases
    for CREB5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CREB5 for disorders           About GeneDecksing

    7 diseases for CREB5:    About MalaCards
    ascariasis    trichuriasis    huntington's disease    adhd
    encephalitis    prostate cancer    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: CREB5 (5 documents)

    Export disorders for CREB5 gene to outside databases

    Publications
    for CREB5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CREB5 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CREB5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. (PubMed id 8378084)1, 2, 3, 9 Zu Y.-L.... Ishii S. (1993)
    2. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. (PubMed id 8440710)1, 2, 3, 9 Nomura N....Ishii S. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
    9. Effects of chronic ascariasis and trichuriasis on cyt okine production and gene expression in human blood: a cross-sectional study. (PubMed id 21666788)1 Reina Ortiz M....Cooper P.J. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for CREB5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      Query String
    		PubMed
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    Genome Databases showing CREB5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9586 HGNC: 16844 AceView: CREB5 Ensembl:ENSG00000146592 euGenes: HUgn9586
    ECgene: CREB5 Kegg: 9586 H-InvDB: CREB5

    Other Databases showing CREB5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CREB5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CREB5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CREB5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CREB5 gene:
    Search GeneIP for patents involving CREB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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