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CREB5 Gene

protein-coding   GIFtS: 56
GCID: GC07P028305

CAMP Responsive Element Binding Protein 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Binding Protein 51 2     CAMP Response Element-Binding Protein CRE-BPa2
CAMP Response Element Binding Protein CRE-Bpa1 2     CAMP Responsive Element Binding Protein 5 Isoform Alpha2
CREB-52 3     Cyclic AMP-Responsive Element-Binding Protein 52
CAMP-Responsive Element-Binding Protein 52 3     CRE-BPa3
CRE-BPA2     CREBPA3
H_GS165L15.12     

External Ids:    HGNC: 168441   Entrez Gene: 95862   Ensembl: ENSG000001465927   UniProtKB: Q029303   

Export aliases for CREB5 gene to outside databases

Previous GC identifers: GC07P028047 GC07P028194 GC07P028081 GC07P028112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREB5 Gene:
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family
contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or
a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced
transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREB5 Gene:
CREB5 (cAMP responsive element binding protein 5) is a protein-coding gene. Diseases associated with CREB5 include ascariasis, and trichuriasis. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ENSG00000267281.

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
Function: Binds to the cAMP response element and activates transcription

Gene Wiki entry for CREB5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB5 gene promoter:
         E2F-4   E2F-3a   E2F-5   RP58   E2F-2   IRF-2   POU2F1   E2F   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CREB5 promoter sequence
   Search Chromatin IP Primers for CREB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p15.1   HGNC cytogenetic band: 7p15

CREB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P028305:  view genomic region     (about GC identifiers)

Start:
28,338,940 bp from pter      End:
28,865,511 bp from pter
Size:
526,572 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 28,389,121-28,915,762     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 5  
Size: 508 amino acids; 56918 Da
Subunit: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1
Secondary accessions: A8KA51 B4DU13 B5BUH3 C9JK47 Q05886 Q06246 Q75N02 Q86UJ9
Alternative splicing: 4 isoforms:  Q02930-1   Q02930-2   Q02930-3   Q02930-4   

Explore the universe of human proteins at neXtProt for CREB5: NX_Q02930

Explore proteomics data for CREB5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys432
  • Modification sites at PhosphoSitePlus

  • See CREB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001011666.1  NP_004895.2  NP_878901.2  NP_878902.2  

    ENSEMBL proteins: 
     ENSP00000379593   ENSP00000394088   ENSP00000350359   ENSP00000379594   ENSP00000387197  
     ENSP00000394979   ENSP00000379592   ENSP00000440429  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    5 InterPro protein domains:
     IPR004827 bZIP
     IPR015880 Znf_C2H2-like
     IPR016378 TF_cAMP-dep
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q02930

    ProtoNet protein and cluster: Q02930

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 C2H2-type zinc finger


    CREB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREB5_HUMAN, Q02930
    Function: Binds to the cAMP response element and activates transcription

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003676nucleic acid binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA8378084
    GO:0005515protein binding IPI8440710
    GO:0043565sequence-specific DNA binding IEA--
         
    CREB5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CREB5:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Creb5):
     adipose tissue  behavior/neurological  cellular  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging 

    CREB5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Creb5tm1Sis for CREB5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREB5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CREB5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREB5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREB5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CREB5:
    hsa-mir-32-5p (MIRT028329), hsa-mir-204-5p (MIRT006460), hsa-mir-211-5p (MIRT006462), hsa-mir-125a-5p (MIRT021286), hsa-mir-10a-5p (MIRT025590)

    Block miRNA regulation of human, mouse, rat CREB5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB5 (see all 198):
    hsa-miR-124* hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-149 hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CREB5
    Predesigned siRNA for gene silencing in human, mouse, rat CREB5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CREB5

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CREB5 (NM_182898)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREB5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB5

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREB5_HUMAN, Q02930: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC8378084
    GO:0070062extracellular vesicular exosome IDA19056867

    CREB5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREB5 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Dopaminergic synapse0.37
    Cholinergic synapse0.37
    3Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Glioma
    Prostate cancer0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Kegg Pathways  (Kegg details for CREB5) (see all 16):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse


    CREB5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREB5
    Interactions:

        Search GeneGlobe Interaction Network for CREB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREB5 (Q029303 ENSP000003503594) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    ATF2P153363, ENSP000002641104I2D: score=1 STRING: ENSP00000264110
    KRTAP5-9P263713I2D: score=1 
    LGALS13Q9UHV83I2D: score=1 
    CREBBPENSP000002623674STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS8378084
    GO:0045444fat cell differentiation IEA--
    GO:0045893positive regulation of transcription, DNA-templated IDA8378084
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ----

    CREB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREB5

    1 HMDB Compound for CREB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CREB5 gene (4 alternative transcripts): 
    NM_001011666.1  NM_004904.2  NM_182898.2  NM_182899.3  

    Unigene Cluster for CREB5:

    CAMP responsive element binding protein 5
    Hs.437075  [show with all ESTs]
    Unigene Representative Sequence: NM_182898
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396299 ENST00000469531 ENST00000478078 ENST00000482692(uc003szp.3)
    ENST00000424599 ENST00000357727(uc003szo.3 uc003szq.3 uc003szr.3 uc003szs.3)
    ENST00000396300 ENST00000409603 ENST00000461921 ENST00000426500 ENST00000396298
    ENST00000468391(uc011jzr.2) ENST00000484383 ENST00000468813 ENST00000498316

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CREB5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB5 (see all 198):
    hsa-miR-124* hsa-miR-520f hsa-miR-361-5p hsa-miR-106a hsa-miR-938 hsa-miR-519a hsa-miR-149 hsa-miR-376a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): CREB5 (NM_182898)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CREB5
      QuantiFast Probe-based Assays in human, mouse, rat CREB5

    Additional mRNA sequence: 

    AB209262.1 AB451409.1 AK021493.1 AK057151.1 AK292916.1 AK298121.1 AK300455.1 AK316187.1 
    BC059400.1 L05515.1 L05911.1 L05912.1 L05913.1 

    12 DOTS entries:

    DT.91750301  DT.100812990  DT.95374150  DT.100812991  DT.97828917  DT.87014787  DT.95209779  DT.97825503 
    DT.100747131  DT.121057538  DT.95225955  DT.438809 

    Selected AceView cDNA sequences (see all 78):

    BM468660 AV754746 AA700776 AL706583 BP345509 BX279704 AA582287 AL706571 
    AA581655 BC059400 CB149302 CK820213 BX490928 BX099680 AI689210 L05911 
    AW071804 BE620362 BI007542 BE887739 AW665405 AU119216 L05515 CD518644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CREB5 Expression
    About this image


    CREB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    CREB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437075
        Custom PCR Arrays for CREB5
    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CREB5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb51 , 5 cAMP responsive element binding protein 51, 5 91.12(n)1
    98.87(a)1
      6 (25.90 cM)5
    2319911  NM_172728.21  NP_766316.11 
     535733745 
    chicken
    (Gallus gallus)
    Aves CREB51 cAMP responsive element binding protein 5 86.06(n)
    94.67(a)
      428435  XM_004939381.1  XP_004939438.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB56
    cAMP responsive element binding protein 5
    93(a)
    1 ↔ 1
    GL343275.1(364116-703330)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia creb51 cAMP responsive element binding protein 5 79.53(n)
    87(a)
      100498464  XM_002933391.2  XP_002933437.2 
    zebrafish
    (Danio rerio)
    Actinopterygii creb5b1 cAMP responsive element binding protein 5b 70.5(n)
    76.15(a)
      565910  XM_001921055.2  XP_001921090.2 


    ENSEMBL Gene Tree for CREB5 (if available)
    TreeFam Gene Tree for CREB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREB5 gene
    ENSG000002672812  ATF72  ATF22  
    2 SIMAP similar genes for CREB5 using alignment to 5 protein entries:     CREB5_HUMAN (see all proteins):
    ATF2    ATF7

    CREB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREB5 (see all 11054)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506803761,2
    C,Funtested128758481(+) TCTTCC/TGCCGT 8 S syn11Minor allele frequency- T:0.00NA 4552
    rs788405531,2
    C--28275323(+) gcctg-/GGGAA 
            
    caaag
    1 -- int10--------
    rs1135528611,2
    C,F--28336976(+) ACAGAC/GAGTAA 1 -- us2k12Minor allele frequency- G:0.03NA 122
    rs1426347451,2
    --28336979(+) GACAGG/TAAGTG 1 -- us2k10--------
    rs1871351851,2
    --28336983(+) GTAAGG/TGGTAG 1 -- us2k10--------
    rs1923593641,2
    --28337040(+) TCCCAC/TTGTGT 1 -- us2k10--------
    rs1833206691,2
    --28337410(+) ATCAAC/TGCTTG 1 -- us2k10--------
    rs1870024291,2
    --28337756(+) TAAACA/GAGTGC 1 -- us2k10--------
    rs1502814031,2
    --28337760(+) CGAGTA/GCCATG 1 -- us2k10--------
    rs1458046591,2
    --28337804(+) GTATTA/CAGCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREB5 (28338940 - 28588940 bp, first 250kb of CREB5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CREB5 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662053CNV Deletion23128226
    esv2470943CNV Deletion19546169
    esv2141048CNV Deletion18987734
    esv3333CNV Deletion18987735
    esv2659069CNV Deletion23128226
    dgv1189e199CNV Deletion23128226
    esv2734175CNV Deletion23290073
    esv2734176CNV Deletion23290073
    nsv821171CNV Deletion20802225
    esv2676680CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    12 diseases for CREB5:    
    About MalaCards
    ascariasis    trichuriasis    diabetic retinopathy    encephalitis
    huntington's disease    inflammatory bowel disease    asthma    hepatitis b
    prostate cancer    prostatitis    hepatitis    thyroiditis


    CREB5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CREB5
    Human Genome Epidemiology (HuGE) Navigator: CREB5 (5 documents)

    Export disorders for CREB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREB5 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CREB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. (PubMed id 8378084)1, 2, 3, 9 Zu Y.-L.... Ishii S. (Oncogene 1993)
    2. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. (PubMed id 8440710)1, 2, 3, 9 Nomura N.... Ishii S. (J. Biol. Chem. 1993)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    7. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9586 HGNC: 16844 AceView: CREB5 Ensembl:ENSG00000146592 euGenes: HUgn9586
    ECgene: CREB5 Kegg: 9586 H-InvDB: CREB5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CREB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CREB5 gene:
    Search GeneIP for patents involving CREB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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