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Aliases for CREB5 Gene

Aliases for CREB5 Gene

  • CAMP Responsive Element Binding Protein 5 2 3 5
  • CRE-BPA 3 4
  • CREB-5 3 4
  • CAMP Response Element Binding Protein CRE-Bpa 2
  • CAMP Response Element-Binding Protein CRE-BPa 3
  • CAMP-Responsive Element-Binding Protein 5 4
  • CREBPA 4

External Ids for CREB5 Gene

Previous GeneCards Identifiers for CREB5 Gene

  • GC07P028047
  • GC07P028194
  • GC07P028081
  • GC07P028112

Summaries for CREB5 Gene

Entrez Gene Summary for CREB5 Gene

  • The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREB5 Gene

CREB5 (CAMP Responsive Element Binding Protein 5) is a Protein Coding gene. Among its related pathways are TNF signaling pathway and cAMP signaling pathway. GO annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ATF2.

UniProtKB/Swiss-Prot for CREB5 Gene

  • Binds to the cAMP response element and activates transcription.

Gene Wiki entry for CREB5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB5 Gene

Genomics for CREB5 Gene

Regulatory Elements for CREB5 Gene

Enhancers for CREB5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CREB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CREB5 Gene

28,299,321 bp from pter
28,825,894 bp from pter
526,574 bases
Plus strand

Genomic View for CREB5 Gene

Genes around CREB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB5 Gene

Proteins for CREB5 Gene

  • Protein details for CREB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclic AMP-responsive element-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • A8KA51
    • B4DU13
    • B5BUH3
    • C9JK47
    • Q05886
    • Q06246
    • Q75N02
    • Q86UJ9

    Protein attributes for CREB5 Gene

    508 amino acids
    Molecular mass:
    56918 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.

    Alternative splice isoforms for CREB5 Gene


neXtProt entry for CREB5 Gene

Proteomics data for CREB5 Gene at MOPED

Post-translational modifications for CREB5 Gene

  • Ubiquitination at Lys 432
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CREB5 Gene

Domains & Families for CREB5 Gene

Gene Families for CREB5 Gene

Suggested Antigen Peptide Sequences for CREB5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family.
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with CREB5: view

Function for CREB5 Gene

Molecular function for CREB5 Gene

UniProtKB/Swiss-Prot Function:
Binds to the cAMP response element and activates transcription.

Gene Ontology (GO) - Molecular Function for CREB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8440710
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREB5: view
genes like me logo Genes that share phenotypes with CREB5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREB5 Gene

Localization for CREB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB5 Gene

Subcellular locations from

Jensen Localization Image for CREB5 Gene COMPARTMENTS Subcellular localization image for CREB5 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for CREB5 Gene

Pathways & Interactions for CREB5 Gene

genes like me logo Genes that share pathways with CREB5: view

Gene Ontology (GO) - Biological Process for CREB5 Gene


No data available for SIGNOR curated interactions for CREB5 Gene

Drugs & Compounds for CREB5 Gene

(1) Drugs for CREB5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CREB5: view

Transcripts for CREB5 Gene

Unigene Clusters for CREB5 Gene

CAMP responsive element binding protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB5 Gene

No ASD Table

Relevant External Links for CREB5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CREB5 Gene

mRNA expression in normal human tissues for CREB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREB5 Gene

This gene is overexpressed in Whole Blood (x14.3).

Protein differential expression in normal tissues from HIPED for CREB5 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREB5 Gene

SOURCE GeneReport for Unigene cluster for CREB5 Gene Hs.437075

genes like me logo Genes that share expression patterns with CREB5: view

Protein tissue co-expression partners for CREB5 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CREB5 Gene

Orthologs for CREB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CREB5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CREB5 35
  • 93.55 (n)
  • 97.01 (a)
-- 36
  • 98 (a)
-- 36
  • 100 (a)
(Canis familiaris)
Mammalia CREB5 35
  • 93.88 (n)
  • 97.41 (a)
CREB5 36
  • 97 (a)
(Mus musculus)
Mammalia Creb5 35
  • 91.12 (n)
  • 98.87 (a)
Creb5 36
  • 98 (a)
(Pan troglodytes)
Mammalia CREB5 35
  • 99.67 (n)
  • 99.41 (a)
CREB5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Creb5 35
  • 91.54 (n)
  • 97.64 (a)
(Monodelphis domestica)
Mammalia CREB5 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia CREB5 36
  • 95 (a)
(Gallus gallus)
Aves CREB5 35
  • 86.06 (n)
  • 94.67 (a)
CREB5 36
  • 95 (a)
(Anolis carolinensis)
Reptilia CREB5 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia creb5 35
  • 79.53 (n)
  • 87 (a)
(Danio rerio)
Actinopterygii creb5b 35
  • 70.5 (n)
  • 76.15 (a)
creb5b 36
  • 80 (a)
Species with no ortholog for CREB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREB5 Gene

Gene Tree for CREB5 (if available)
Gene Tree for CREB5 (if available)

Paralogs for CREB5 Gene

Paralogs for CREB5 Gene

(2) SIMAP similar genes for CREB5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CREB5: view

Variants for CREB5 Gene

Sequence variations from dbSNP and Humsavar for CREB5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs765864 -- 28,643,488(-) TAAGG(C/G/T)GGGGG intron-variant
rs767834 -- 28,586,758(+) GTAAG(C/G)AAACT intron-variant
rs879591 -- 28,719,397(-) tgtga(G/T)gatca intron-variant
rs879592 -- 28,719,031(-) GGCCC(C/T)CAAAG intron-variant
rs879593 -- 28,719,021(-) GCAAA(A/C)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB5 Gene

Variant ID Type Subtype PubMed ID
nsv830931 CNV Gain 17160897
nsv5678 CNV Loss 18451855
nsv830932 CNV Gain+Loss 17160897
nsv887894 CNV Gain 21882294
esv2659069 CNV Deletion 23128226
nsv464414 CNV Gain 19166990
nsv511954 CNV Loss 21212237
esv24798 CNV Gain+Loss 19812545
nsv821171 CNV Deletion 20802225
esv3333 CNV Deletion 18987735
dgv1189e199 CNV Deletion 23128226
esv2734175 CNV Deletion 23290073
nsv824044 CNV Gain 20364138
esv2470943 CNV Deletion 19546169
esv2141048 CNV Deletion 18987734
esv2734176 CNV Deletion 23290073
esv2676680 CNV Deletion 23128226
esv1447352 CNV Insertion 17803354
nsv830933 CNV Loss 17160897
nsv5679 CNV Loss 18451855
esv25736 CNV Loss 19812545
esv2662053 CNV Deletion 23128226

Variation tolerance for CREB5 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CREB5 Gene

Disorders for CREB5 Gene

Relevant External Links for CREB5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CREB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CREB5 Gene

Publications for CREB5 Gene

  1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. (PMID: 8378084) Zu Y.-L. … Ishii S. (Oncogene 1993) 2 3 4 23 67
  2. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. (PMID: 8440710) Nomura N. … Ishii S. (J. Biol. Chem. 1993) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3

Products for CREB5 Gene

Sources for CREB5 Gene