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CREB3L4 Gene

protein-coding   GIFtS: 55
GCID: GC01P153940

CAMP Responsive Element Binding Protein 3-Like 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Binding Protein 3-Like 41 2     CAMP-Responsive Element-Binding Protein 3-Like Protein 42 3
AIBZIP2 3 5     CAMP-Responsive Element-Binding Protein 42 3
CREB42 3 5     hJAL2 3
Androgen-Induced Basic Leucine Zipper Protein2 3     CREB32
Attaching To CRE-Like 12 3     CAMP Responsive Element Binding Protein 12
Cyclic AMP-Responsive Element-Binding Protein 42 3     Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 42
Transcript Induced In Spermiogenesis Protein 402 3     tisp402
ATCE12 3     AIbZIP3
CREB-42 3     Tisp403
JAL2 3     

External Ids:    HGNC: 188541   Entrez Gene: 1483272   Ensembl: ENSG000001435787   OMIM: 6071385   UniProtKB: Q8TEY53   

Export aliases for CREB3L4 gene to outside databases

Previous GC identifers: GC01P151157 GC01P150753 GC01P152207 GC01P125302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREB3L4 Gene:
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it
to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and
this protein may function in a number of processing pathways including protein processing. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CREB3L4 Gene:
CREB3L4 (cAMP responsive element binding protein 3-like 4) is a protein-coding gene. Diseases associated with CREB3L4 include prostate disease, and huntington's disease. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB3L2.

UniProtKB/Swiss-Prot: CR3L4_HUMAN, Q8TEY5
Function: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR
element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence
5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has
transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB3L4 gene promoter:
         STAT5A   Tal-1beta   CREB   PPAR-gamma1   USF-1   deltaCREB   PPAR-gamma2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB3L4 promoter sequence
   Search Chromatin IP Primers for CREB3L4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

CREB3L4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3L4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153940:  view genomic region     (about GC identifiers)

Start:
153,940,010 bp from pter      End:
153,946,839 bp from pter
Size:
6,830 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CR3L4_HUMAN, Q8TEY5 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3-like protein 4  
Size: 395 amino acids; 43432 Da
Subunit: Binds DNA as a dimer (By similarity)
Secondary accessions: D3DV62 Q5T4L0 Q86YW6
Alternative splicing: 2 isoforms:  Q8TEY5-1   Q8TEY5-2   

Explore the universe of human proteins at neXtProt for CREB3L4: NX_Q8TEY5

Explore proteomics data for CREB3L4 at MOPED

Post-translational modifications: 

  • N-glycosylated in the C-terminal region1
  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic
    transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1
    and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By
    similarity)1
  • Ubiquitination2 at Lys51, Lys194
  • Glycosylation2 at Thr339, Thr344, Thr349, Ser354, Asn366
  • Modification sites at PhosphoSitePlus

  • See CREB3L4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001242907.1  NP_001242908.1  NP_001242909.1  NP_001242910.1  NP_570968.1  

    ENSEMBL proteins: 
     ENSP00000391847   ENSP00000357596   ENSP00000271889   ENSP00000357590   ENSP00000357592  
     ENSP00000357589   ENSP00000402308   ENSP00000385104  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q8TEY5

    ProtoNet protein and cluster: Q8TEY5

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CR3L4_HUMAN, Q8TEY5
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREB3L4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR3L4_HUMAN, Q8TEY5
    Function: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR
    element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence
    5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has
    transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity)
    Induction: By androgens

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    CREB3L4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CREB3L4:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Creb3l4):
     endocrine/exocrine gland  reproductive system 

    CREB3L4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Creb3l4tm1Noj for CREB3L4

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    hsa-miR-3163
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CR3L4_HUMAN, Q8TEY5: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus
    membrane; Single-pass type II membrane protein (Potential). Note=May also be located in Golgi apparatus
    CR3L4_HUMAN, Q8TEY5: Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus.
    Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus5
    cytosol1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    CREB3L4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREB3L4 About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2CREB Pathway
    CREB Pathway0.68
    Activation of PKC through GPCR0.63
    IP3 Pathway0.68
    Intracellular Calcium Signaling0.50
    3GPCR Pathway
    GPCR Pathway0.62
    P2Y Receptor Signaling0.38
    Estrogen Pathway0.55
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5ErbB4 Pathway
    LPS Stimulated MAPK Signaling0.47
    PI3K Signaling in B-Lymphocyte0.35
    PACAP Signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CREB3L4 (see all 45)
        FLT3 Signaling
    Nuclear Receptor Activation by Vitamin-A
    Toll-Like Receptors Pathway
    Interferon Pathway
    Intracellular Calcium Signaling

    1 BioSystems Pathway for CREB3L4
        G1 to S cell cycle control



    Selected Kegg Pathways  (Kegg details for CREB3L4) (see all 17):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse


    CREB3L4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREB3L4
    Interactions:

        Search GeneGlobe Interaction Network for CREB3L4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREB3L4 (Q8TEY53 ENSP000002718894) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREMQ030603, ENSP000002653724I2D: score=2 STRING: ENSP00000265372
    DDX41Q9UJV93, ENSP000003303494I2D: score=1 STRING: ENSP00000330349
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    HIRAP541983, ENSP000002632084I2D: score=1 STRING: ENSP00000263208
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006986response to unfolded protein IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    CREB3L4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CREB3L4 (CR3L4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CREB3L4 gene (5 alternative transcripts): 
    NM_001255978.1  NM_001255979.1  NM_001255980.1  NM_001255981.1  NM_130898.3  

    Unigene Cluster for CREB3L4:

    CAMP responsive element binding protein 3-like 4
    Hs.372924  [show with all ESTs]
    Unigene Representative Sequence: NM_130898
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477617 ENST00000449724 ENST00000368607(uc001fdn.3 uc001fdo.3)
    ENST00000271889(uc001fdm.1) ENST00000461688 ENST00000368601 ENST00000368603(uc001fdr.2 uc001fdq.2)
    ENST00000368600 ENST00000479010 ENST00000492729(uc010peg.1) ENST00000473340
    ENST00000431292 ENST00000468845 ENST00000405694(uc010pef.1)
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    Additional mRNA sequence: 

    AB052778.1 AF394167.1 AF468007.1 AK297703.1 AK304259.1 AK304665.1 AY049977.1 BC038962.1 
    BX647716.1 NR_045658.1 

    17 DOTS entries:

    DT.421099  DT.97844583  DT.97844584  DT.75133749  DT.100776366  DT.100776368  DT.121436532  DT.95277031 
    DT.121436443  DT.95098506  DT.102825513  DT.121436551  DT.100670043  DT.100776364  DT.121436403  DT.95149731 
    DT.121436428 

    Selected AceView cDNA sequences (see all 165):

    BQ950696 AL528908 CD674840 AB052778 BM846254 AI493479 AA337698 BM846663 
    BF589634 AI130985 CB068529 BI768195 CR621422 CR610829 CR592077 AF394167 
    AA587806 BM977529 CR624438 BM847044 CA454251 AI872174 NM_130898 AI151181 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:        -     -                                                   
    SP2:              -           -                                       
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for CREB3L4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREB3L4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATGAGAT
    CREB3L4 Expression
    About this image

    CREB3L4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB3L4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372924

    UniProtKB/Swiss-Prot: CR3L4_HUMAN, Q8TEY5
    Tissue specificity: According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and
    prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is
    significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According
    to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small
    intestine, testis, leukocyte and thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREB3L4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb3l41 , 5 cAMP responsive element binding protein 3-like 41, 5 79.96(n)1
    71.31(a)1
      3 (39.21 cM)5
    782841  NM_030080.21  NP_084356.11 
     902375005 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia creb3l41 cAMP responsive element binding protein 3-like 4 64.4(n)
    62.59(a)
      780164  NM_001079239.1  NP_001072707.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb26f102 Transcribed sequence with weak similarity to protein more 75.43(n)    57039665 
    worm
    (Caenorhabditis elegans)
    Secernentea let-6076
    Protein LET-607 (let-607) mRNA, complete cds
    13(a)
    1 → many
    I(6574004-6585175) WBGene00002783


    ENSEMBL Gene Tree for CREB3L4 (if available)
    TreeFam Gene Tree for CREB3L4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREB3L4 gene
    CREB3L22  CREB32  CREB3L12  CREB3L32  
    2 SIMAP similar genes for CREB3L4 using alignment to 5 protein entries:     CR3L4_HUMAN (see all proteins):
    CREM    CREB3L3

    CREB3L4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREB3L4 (see all 95)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826421091,2
    --153942761(+) GGTAAG/TGTAGC 6 -- int10--------
    rs1877237781,2
    --153943044(+) AAGGCC/TGTCTG 6 -- int10--------
    rs124039561,2
    C,F,A,H--153943079(+) AGGGGA/GCTATG 6 -- int1 trp320Minor allele frequency- G:0.28NS EA NA CSA WA 2504
    rs1931026681,2
    C--153943283(+) TGGCAC/TCATCT 6 -- int10--------
    rs1834382881,2
    --153943324(+) CAAGCA/GATTCT 6 -- int10--------
    rs2017372551,2
    C--153943576(+) GCGCGG/TTNNNN 6 -- int10--------
    rs66713621,2
    C,F,A,H--153943788(+) gcagtG/Aagtgg 6 -- int14Minor allele frequency- A:0.38NA WA CSA 8
    rs66667031,2
    C,F,A,H--153943800(+) gattgC/Tgccat 6 -- int12Minor allele frequency- T:0.50NA CSA 4
    rs66669121,2
    C,F,H--153944063(+) tttttC/Tttttt 6 -- int1 trp33Minor allele frequency- T:0.39NS NA 174
    rs559309061,2
    C--153944063(+) TTTCT-/T/TT  
            
    TTTTT
    6 -- int10--------

    HapMap Linkage Disequilibrium report for CREB3L4 (153940010 - 153946839 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CREB3L4: --
    Human Gene Mutation Database (HGMD): CREB3L4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB3L4
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB3L4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607138    OMIM disorders: --

    9 diseases for CREB3L4:    
    About MalaCards
    prostate disease    huntington's disease    prostatitis    hepatocellular carcinoma
    sarcoma    prostate cancer    hepatitis b    thyroiditis
    hepatitis


    CREB3L4 for disorders           About GeneDecksing


    Export disorders for CREB3L4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREB3L4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CREB3L4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up- regulated by androgens in LNCaP human prostate cancer cells. (PubMed id 11830526)1, 2, 9 Qi H.... Labrie C. (Cancer Res. 2002)
    2. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. (PubMed id 16236796)1, 2 Stirling J. and O'hare P. (Mol. Biol. Cell 2006)
    3. Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4). (PubMed id 12111373)1, 2 Cao G.... Mao Y. (J. Hum. Genet. 2002)
    4. Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. (PubMed id 17712038)1, 9 Ben Aicha S....Labrie C. (Physiol. Genomics 2007)
    5. Genome-wide association identifies genetic variants associated with lentiform nucleus volume in Na88=a881345 young and elderly subjects. (PubMed id 22903471)1 Hibar D.P....Thompson P.M. (Brain Imaging Behav 2013)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma. (PubMed id 18068530)1 Inagaki Y....Okanoue T. (Cancer Genet. Cytogenet. 2008)
    10. Androgen-regulated transcription factor AIbZIP in prostate cancer. (PubMed id 17933519)1 Labrie C....Calvo E. (J. Steroid Biochem. Mol. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 148327 HGNC: 18854 AceView: CREB3L4 Ensembl:ENSG00000143578 euGenes: HUgn148327
    ECgene: CREB3L4 Kegg: 148327 H-InvDB: CREB3L4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREB3L4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREB3L4 gene:
    Search GeneIP for patents involving CREB3L4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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