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Aliases for CREB3L4 Gene

Aliases for CREB3L4 Gene

  • CAMP Responsive Element Binding Protein 3-Like 4 2 3
  • AIBZIP 3 4 6
  • CREB4 3 4 6
  • CAMP-Responsive Element-Binding Protein 3-Like Protein 4 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 4 3 4
  • Transcript Induced In Spermiogenesis Protein 40 3 4
  • Androgen-Induced Basic Leucine Zipper Protein 3 4
  • CAMP-Responsive Element-Binding Protein 4 3 4
  • Attaching To CRE-Like 1 3 4
  • Tisp40 3 4
  • CREB-4 3 4
  • ATCE1 3 4
  • HJAL 3 4
  • JAL 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 3
  • CAMP Responsive Element Binding Protein 1 3
  • CREB3 3

External Ids for CREB3L4 Gene

Previous GeneCards Identifiers for CREB3L4 Gene

  • GC01P151157
  • GC01P150753
  • GC01P152207
  • GC01P125302

Summaries for CREB3L4 Gene

Entrez Gene Summary for CREB3L4 Gene

  • This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CREB3L4 Gene

CREB3L4 (CAMP Responsive Element Binding Protein 3-Like 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3L4 Gene

  • Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5-T[GT]ACGT[GA][GT]-3 and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3L4 Gene

Genomics for CREB3L4 Gene

Regulatory Elements for CREB3L4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CREB3L4 Gene

Start:
153,967,534 bp from pter
End:
153,974,364 bp from pter
Size:
6,831 bases
Orientation:
Plus strand

Genomic View for CREB3L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREB3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3L4 Gene

Proteins for CREB3L4 Gene

  • Protein details for CREB3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEY5-CR3L4_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 4
    Protein Accession:
    Q8TEY5
    Secondary Accessions:
    • D3DV62
    • Q5T4L0
    • Q86YW6

    Protein attributes for CREB3L4 Gene

    Size:
    395 amino acids
    Molecular mass:
    43432 Da
    Quaternary structure:
    • Binds DNA as a dimer.

    Alternative splice isoforms for CREB3L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3L4 Gene

Proteomics data for CREB3L4 Gene at MOPED

Post-translational modifications for CREB3L4 Gene

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
  • N-glycosylated in the C-terminal region.
  • Ubiquitination at Lys51 and Lys194
  • Glycosylation at Thr339, Thr344, Thr349, Ser354, and Asn366
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CREB3L4 Gene

Domains for CREB3L4 Gene

Gene Families for CREB3L4 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CREB3L4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TEY5

UniProtKB/Swiss-Prot:

CR3L4_HUMAN :
  • Q8TEY5
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3L4: view

Function for CREB3L4 Gene

Molecular function for CREB3L4 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5-T[GT]ACGT[GA][GT]-3 and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
UniProtKB/Swiss-Prot Induction: By androgens

Gene Ontology (GO) - Molecular Function for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0035497 cAMP response element binding IEA --
genes like me logo Genes that share ontologies with CREB3L4: view

Phenotypes for CREB3L4 Gene

genes like me logo Genes that share phenotypes with CREB3L4: view

Animal Models for CREB3L4 Gene

MGI Knock Outs for CREB3L4:

Animal Model Products

CRISPR Products

miRNA for CREB3L4 Gene

miRTarBase miRNAs that target CREB3L4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREB3L4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CREB3L4 Gene

Localization for CREB3L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3L4 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3L4 Gene COMPARTMENTS Subcellular localization image for CREB3L4 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IDA 16236796
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IDA 16236796
genes like me logo Genes that share ontologies with CREB3L4: view

Pathways for CREB3L4 Gene

genes like me logo Genes that share pathways with CREB3L4: view

Gene Ontology (GO) - Biological Process for CREB3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006986 response to unfolded protein --
GO:0007283 spermatogenesis IEA --
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
genes like me logo Genes that share ontologies with CREB3L4: view

Transcripts for CREB3L4 Gene

Unigene Clusters for CREB3L4 Gene

CAMP responsive element binding protein 3-like 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREB3L4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for CREB3L4 Gene

GeneLoc Exon Structure for
CREB3L4
ECgene alternative splicing isoforms for
CREB3L4

Expression for CREB3L4 Gene

mRNA expression in normal human tissues for CREB3L4 Gene

mRNA differential expression in normal tissues according to GTEx for CREB3L4 Gene

This gene is overexpressed in Prostate (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREB3L4 Gene

SOURCE GeneReport for Unigene cluster for CREB3L4 Gene Hs.372924

mRNA Expression by UniProt/SwissProt for CREB3L4 Gene

Q8TEY5-CR3L4_HUMAN
Tissue specificity: According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
genes like me logo Genes that share expressions with CREB3L4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CREB3L4 Gene

Orthologs for CREB3L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3L4 35
  • 99.64 (n)
  • 99.2 (a)
CREB3L4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB3L4 35
  • 86.51 (n)
  • 83.38 (a)
CREB3L4 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB3L4 35
  • 85.22 (n)
  • 80.65 (a)
CREB3L4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb3l4 35
  • 79.96 (n)
  • 71.31 (a)
Creb3l4 16
Creb3l4 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB3L4 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Creb3l4 35
  • 80.74 (n)
  • 73.57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3l4 35
  • 64.4 (n)
  • 62.59 (a)
zebrafish
(Danio rerio)
Actinopterygii CREB3L4 36
  • 41 (a)
OneToOne
LOC100333318 35
  • 58.56 (n)
  • 52 (a)
wufb26f10 35
worm
(Caenorhabditis elegans)
Secernentea let-607 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for CREB3L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3L4 Gene

ENSEMBL:
Gene Tree for CREB3L4 (if available)
TreeFam:
Gene Tree for CREB3L4 (if available)

Paralogs for CREB3L4 Gene

Paralogs for CREB3L4 Gene

Selected SIMAP similar genes for CREB3L4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CREB3L4: view

Variants for CREB3L4 Gene

Sequence variations from dbSNP and Humsavar for CREB3L4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6666703 -- 153,971,324(+) gattg(C/T)gccat intron-variant
rs6666912 -- 153,971,587(+) ttttt(C/T)ttttt intron-variant
rs6671362 -- 153,971,312(+) gcagt(A/G)agtgg intron-variant
rs12403956 -- 153,970,603(+) AGGGG(A/G)CTATG intron-variant
rs12563892 -- 153,972,276(+) AGACC(C/T)TAAGG intron-variant

Relevant External Links for CREB3L4 Gene

HapMap Linkage Disequilibrium report
CREB3L4
Human Gene Mutation Database (HGMD)
CREB3L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CREB3L4 Gene

Disorders for CREB3L4 Gene

No disorders were found for CREB3L4 Gene.

No data available for UniProtKB/Swiss-Prot for CREB3L4 Gene

Publications for CREB3L4 Gene

  1. AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is highly expressed in prostate tumors and of which the expression is up- regulated by androgens in LNCaP human prostate cancer cells. (PMID: 11830526) Qi H. … Labrie C. (Cancer Res. 2002) 3 4 23
  2. Transcriptional profiling of genes that are regulated by the endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in prostate cells. (PMID: 17712038) Ben Aicha S. … Labrie C. (Physiol. Genomics 2007) 3 23
  3. Molecular cloning and characterization of a novel human cAMP response element-binding (CREB) gene (CREB4). (PMID: 12111373) Cao G. … Mao Y. (J. Hum. Genet. 2002) 3 4
  4. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. (PMID: 16236796) Stirling J. … O'hare P. (Mol. Biol. Cell 2006) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CREB3L4 Gene

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