Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREB3L3 Gene

Aliases for CREB3L3 Gene

  • CAMP Responsive Element Binding Protein 3-Like 3 2 3 5
  • CREBH 3 4
  • CAMP-Responsive Element-Binding Protein 3-Like Protein 3 4
  • CREB/ATF Family Transcription Factor 3
  • Transcription Factor CREB-H 4
  • HYST1481 3
  • CREB-H 3

External Ids for CREB3L3 Gene

Previous GeneCards Identifiers for CREB3L3 Gene

  • GC19P004104
  • GC19P003917

Summaries for CREB3L3 Gene

Entrez Gene Summary for CREB3L3 Gene

  • This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for CREB3L3 Gene

CREB3L3 (CAMP Responsive Element Binding Protein 3-Like 3) is a Protein Coding gene. Diseases associated with CREB3L3 include hyperchylomicronemia, late-onset and hepatocellular carcinoma. Among its related pathways are cAMP signaling pathway and Insulin secretion. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is CREB3L4.

UniProtKB/Swiss-Prot for CREB3L3 Gene

  • Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3L3 Gene

Genomics for CREB3L3 Gene

Regulatory Elements for CREB3L3 Gene

Genomic Location for CREB3L3 Gene

Chromosome:
19
Start:
4,153,601 bp from pter
End:
4,173,054 bp from pter
Size:
19,454 bases
Orientation:
Plus strand

Genomic View for CREB3L3 Gene

Genes around CREB3L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB3L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB3L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3L3 Gene

Proteins for CREB3L3 Gene

  • Protein details for CREB3L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CJ9-CR3L3_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 3
    Protein Accession:
    Q68CJ9
    Secondary Accessions:
    • B2R7S6
    • B7ZL69
    • M0QYW7
    • Q6ZMC5
    • Q96TB9

    Protein attributes for CREB3L3 Gene

    Size:
    461 amino acids
    Molecular mass:
    49077 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6.
    SequenceCaution:
    • Sequence=BAD18804.1; Type=Frameshift; Positions=445; Evidence={ECO:0000305}; Sequence=BAD18804.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for CREB3L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3L3 Gene

Proteomics data for CREB3L3 Gene at MOPED

Post-translational modifications for CREB3L3 Gene

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).
  • N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Ser 379, Asn 410, Asn 413, Asn 420, and Asn 427
  • Modification sites at PhosphoSitePlus

Other Protein References for CREB3L3 Gene

No data available for DME Specific Peptides for CREB3L3 Gene

Domains & Families for CREB3L3 Gene

Gene Families for CREB3L3 Gene

Protein Domains for CREB3L3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CREB3L3 Gene

Graphical View of Domain Structure for InterPro Entry

Q68CJ9

UniProtKB/Swiss-Prot:

CR3L3_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3L3: view

Function for CREB3L3 Gene

Molecular function for CREB3L3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.

Gene Ontology (GO) - Molecular Function for CREB3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 16469704
GO:0042803 protein homodimerization activity IDA 16469704
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CREB3L3: view
genes like me logo Genes that share phenotypes with CREB3L3: view

Human Phenotype Ontology for CREB3L3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CREB3L3 Gene

MGI Knock Outs for CREB3L3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CREB3L3 Gene

Localization for CREB3L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3L3 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-responsive element-binding protein 3-like protein 3: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3L3 Gene COMPARTMENTS Subcellular localization image for CREB3L3 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CREB3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CREB3L3: view

Pathways & Interactions for CREB3L3 Gene

genes like me logo Genes that share pathways with CREB3L3: view

Pathways by source for CREB3L3 Gene

Gene Ontology (GO) - Biological Process for CREB3L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002675 positive regulation of acute inflammatory response NAS 16469704
GO:0006366 transcription from RNA polymerase II promoter IDA 11353085
GO:0030968 endoplasmic reticulum unfolded protein response IEA --
genes like me logo Genes that share ontologies with CREB3L3: view

No data available for SIGNOR curated interactions for CREB3L3 Gene

Drugs & Compounds for CREB3L3 Gene

(1) Drugs for CREB3L3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CREB3L3: view

Transcripts for CREB3L3 Gene

mRNA/cDNA for CREB3L3 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CREB3L3 Gene

CAMP responsive element binding protein 3-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3: - - -

Relevant External Links for CREB3L3 Gene

GeneLoc Exon Structure for
CREB3L3
ECgene alternative splicing isoforms for
CREB3L3

Expression for CREB3L3 Gene

mRNA expression in normal human tissues for CREB3L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREB3L3 Gene

This gene is overexpressed in Liver (x47.5) and Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for CREB3L3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (60.1) and NK cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CREB3L3 Gene



SOURCE GeneReport for Unigene cluster for CREB3L3 Gene Hs.247744

mRNA Expression by UniProt/SwissProt for CREB3L3 Gene

Q68CJ9-CR3L3_HUMAN
Tissue specificity: Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
genes like me logo Genes that share expression patterns with CREB3L3: view

Protein tissue co-expression partners for CREB3L3 Gene

Primer Products

In Situ Assay Products

Orthologs for CREB3L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3L3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CREB3L3 35
  • 79.09 (n)
  • 75.88 (a)
CREB3L3 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB3L3 35
  • 79.18 (n)
  • 75.33 (a)
CREB3L3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb3l3 35
  • 75 (n)
  • 72.79 (a)
Creb3l3 16
Creb3l3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CREB3L3 35
  • 98.92 (n)
  • 98.7 (a)
CREB3L3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb3l3 35
  • 73.26 (n)
  • 71.46 (a)
oppossum
(Monodelphis domestica)
Mammalia CREB3L3 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB3L3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CREB3L3 35
  • 65.75 (n)
  • 66.76 (a)
CREB3L3 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733496 35
  • 54.67 (n)
  • 53.39 (a)
zebrafish
(Danio rerio)
Actinopterygii creb3l3a 35
  • 61.34 (n)
  • 59.74 (a)
CREB3L3 (2 of 2) 36
  • 41 (a)
OneToMany
creb3l3a 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-607 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for CREB3L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3L3 Gene

ENSEMBL:
Gene Tree for CREB3L3 (if available)
TreeFam:
Gene Tree for CREB3L3 (if available)

Paralogs for CREB3L3 Gene

Paralogs for CREB3L3 Gene

(1) SIMAP similar genes for CREB3L3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CREB3L3: view

Variants for CREB3L3 Gene

Sequence variations from dbSNP and Humsavar for CREB3L3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs164635 -- 4,157,714(+) AGAGT(C/T)TCACT intron-variant
rs168423 -- 4,170,471(-) ccacg(C/T)ctggc intron-variant
rs641554 -- 4,164,181(-) cctgg(C/T)caaca intron-variant
rs1808260 -- 4,165,886(+) AAAAA(C/T)AAAAA intron-variant
rs586427 -- 4,168,144(-) gcggg(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB3L3 Gene

Variant ID Type Subtype PubMed ID
nsv910783 CNV Loss 21882294
esv2717979 CNV Deletion 23290073
dgv3673n71 CNV Loss 21882294
nsv910816 CNV Loss 21882294
nsv833716 CNV Loss 17160897
nsv910817 CNV Loss 21882294
nsv910818 CNV Loss 21882294

Variation tolerance for CREB3L3 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREB3L3 Gene

HapMap Linkage Disequilibrium report
CREB3L3
Human Gene Mutation Database (HGMD)
CREB3L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB3L3 Gene

Disorders for CREB3L3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CREB3L3 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hyperchylomicronemia, late-onset
  • hyperlipoproteinemia type v
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CREB3L3

Genetic Association Database (GAD)
CREB3L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREB3L3
genes like me logo Genes that share disorders with CREB3L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB3L3 Gene

Publications for CREB3L3 Gene

  1. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver- specific expression. (PMID: 11353085) Omori Y. … Sugano S. (Nucleic Acids Res. 2001) 2 3 4 67
  2. HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress. (PMID: 25428452) Cho H.K. … Cheong J. (Biochem. J. 2015) 3
  3. Novel CREB3L3 Nonsense Mutation in a Family With Dominant Hypertriglyceridemia. (PMID: 26427795) CefalA^ A.B. … Averna M.R. (Arterioscler. Thromb. Vasc. Biol. 2015) 3
  4. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PMID: 23661758) Reinke A.W. … Keating A.E. (Science 2013) 3
  5. Identification and characterization of cyclic AMP response element-binding protein H response element in the human apolipoprotein A5 gene promoter. (PMID: 23957007) Song K.H. … Ma J.Y. (Biomed Res Int 2013) 3

Products for CREB3L3 Gene

Sources for CREB3L3 Gene

Back to Top

Content