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CREB3L3 Gene

protein-coding   GIFtS: 54
GCID: GC19P004153

CAMP Responsive Element Binding Protein 3-Like 3

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Binding Protein 3-Like 31 2     Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 32
CREBH2 3 5     CAMP-Responsive Element-Binding Protein 3-Like Protein 33
CREB-H2     Transcription Factor CREB-H3
CREB/ATF Family Transcription Factor2     

External Ids:    HGNC: 188551   Entrez Gene: 846992   Ensembl: ENSG000000605667   OMIM: 6119985   UniProtKB: Q68CJ93   

Export aliases for CREB3L3 gene to outside databases

Previous GC identifers: GC19P004104 GC19P003917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREB3L3 Gene:
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family.
The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by
cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and
has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin
expression. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for CREB3L3 Gene:
CREB3L3 (cAMP responsive element binding protein 3-like 3) is a protein-coding gene. Diseases associated with CREB3L3 include hyperlipoproteinemia type v, and myxoid liposarcoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB3L2.

UniProtKB/Swiss-Prot: CR3L3_HUMAN, Q68CJ9
Function: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein
response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element
(CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By
similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression
of acute phase response (APR) genes. May be involved in growth suppression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB3L3 gene promoter:
         TBP   CREB   Elk-1   deltaCREB   STAT3   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB3L3 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CREB3L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3L3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004153:  view genomic region     (about GC identifiers)

Start:
4,153,598 bp from pter      End:
4,173,051 bp from pter
Size:
19,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CR3L3_HUMAN, Q68CJ9 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3-like protein 3  
Size: 461 amino acids; 49077 Da
Subunit: Binds DNA as a dimer (By similarity). Probably homodimerizes. Probably forms a heterodimer with ATF6.
Interacts with ATF6
Sequence caution: Sequence=BAD18804.1; Type=Frameshift; Positions=445; Sequence=BAD18804.1; Type=Miscellaneous
discrepancy; Note=Aberrant splicing;
Secondary accessions: B2R7S6 Q6ZMC5 Q96TB9
Alternative splicing: 2 isoforms:  Q68CJ9-1   Q68CJ9-2   

Explore the universe of human proteins at neXtProt for CREB3L3: NX_Q68CJ9

Explore proteomics data for CREB3L3 at MOPED

Post-translational modifications: 

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic
    transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1
    and site-2 proteases (PS1 and PS2)1
  • N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1
    or possibly core 8 glycans1
  • Glycosylation2 at Ser379, Asn410, Asn413, Asn420, Asn427
  • Modification sites at PhosphoSitePlus

  • See CREB3L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001258924.1  NP_001258925.1  NP_001258926.1  NP_115996.1  

    ENSEMBL proteins: 
     ENSP00000078445   ENSP00000469355   ENSP00000472399   ENSP00000470119   ENSP00000252587  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q68CJ9

    ProtoNet protein and cluster: Q68CJ9

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CR3L3_HUMAN, Q68CJ9
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREB3L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR3L3_HUMAN, Q68CJ9
    Function: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein
    response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element
    (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By
    similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression
    of acute phase response (APR) genes. May be involved in growth suppression

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI16469704
    GO:0043565sequence-specific DNA binding IEA--
         
    CREB3L3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Creb3l3):
     homeostasis/metabolism  immune system  mortality/aging  normal 

    CREB3L3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CREB3L3: Creb3l3tm1Ktak Creb3l3tm1.1Sad

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREB3L3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CR3L3_HUMAN, Q68CJ9: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    CR3L3_HUMAN, Q68CJ9: Processed cyclic AMP-responsive element-binding protein 3-like protein 3: Nucleus.
    Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    CREB3L3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREB3L3 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Dopaminergic synapse0.37
    Cholinergic synapse0.37
    3Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Glioma
    Prostate cancer0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CREB3L3
        G1 to S cell cycle control


    Selected Kegg Pathways  (Kegg details for CREB3L3) (see all 17):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse


    CREB3L3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CREB3L3: 
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CREB3L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CREB3L3 (Q68CJ91, 2, 3 ENSP000000784454) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF6P188501, 3, ENSP000003569194EBI-852194,EBI-852157 I2D: score=2 STRING: ENSP00000356919
    USP7Q930092, 3, ENSP000003435354MINT-2877383 I2D: score=3 STRING: ENSP00000343535
    CEBPGP535673, ENSP000002840004I2D: score=2 STRING: ENSP00000284000
    CREB3L1Q96BA83, ENSP000002884004I2D: score=2 STRING: ENSP00000288400
    CREMQ030603I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006986response to unfolded protein IEA--

    CREB3L3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CREB3L3 (CR3L3)

    1 HMDB Compound for CREB3L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CREB3L3 gene (4 alternative transcripts): 
    NM_001271995.1  NM_001271996.1  NM_001271997.1  NM_032607.2  

    Unigene Cluster for CREB3L3:

    CAMP responsive element binding protein 3-like 3
    Hs.247744  [show with all ESTs]
    Unigene Representative Sequence: NM_032607
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000078445(uc002lzl.3 uc002lzm.3 uc010xib.2 uc010xic.2)
    ENST00000595923 ENST00000602257 ENST00000602147 ENST00000598894 ENST00000252587


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    Additional mRNA sequence: 

    AB050902.1 AB073612.1 AK172839.1 AK313099.1 BC101504.1 BC101508.1 BC143609.1 BC143610.1 

    1 DOTS entry:

    DT.95178519 

    7 AceView cDNA sequences:

    AB073612 AB050902 NM_032607 BM856415 AK172839 BX484017 BM843273 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                            -     -     -                     


    ECgene alternative splicing isoforms for CREB3L3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREB3L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCCCATCG
    CREB3L3 Expression
    About this image

    CREB3L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB3L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247744

    UniProtKB/Swiss-Prot: CR3L3_HUMAN, Q68CJ9
    Tissue specificity: Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including CREB3L3: 
              Unfolded Protein Response in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREB3L3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb3l31 , 5 cAMP responsive element binding protein 3-like 31, 5 75(n)1
    72.79(a)1
      10 (39.72 cM)5
    2086771  NM_145365.31  NP_663340.11 
     810843245 
    chicken
    (Gallus gallus)
    Aves CREB3L31 cAMP responsive element binding protein 3-like 3 65.75(n)
    66.76(a)
      428333  XM_425893.4  XP_425893.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017334961 cyclic AMP-responsive element-binding protein 3-like more 54.67(n)
    53.39(a)
      101733496  XM_004919576.1  XP_004919633.1 
    zebrafish
    (Danio rerio)
    Actinopterygii creb3l3a1 cAMP responsive element binding protein 3-like 3a 61.34(n)
    59.74(a)
      553700  NM_001020673.1  NP_001018509.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-6076
    Protein LET-607 (let-607) mRNA, complete cds
    17(a)
    1 → many
    I(6574004-6585175) WBGene00002783


    ENSEMBL Gene Tree for CREB3L3 (if available)
    TreeFam Gene Tree for CREB3L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREB3L3 gene
    CREB3L22  CREB32  CREB3L42  CREB3L12  
    1 SIMAP similar gene for CREB3L3 using alignment to 4 protein entries:     CR3L3_HUMAN (see all proteins):
    CREB3L4

    CREB3L3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREB3L3 (see all 649)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425087791,2
    --4151631(+) CCCTGC/GTGTTT 4 -- us2k10--------
    rs1848705251,2
    --4151736(+) CCCTGC/TCTTCC 4 -- us2k10--------
    rs729789651,2
    C,F--4151815(+) GCTAGG/TCACGG 4 -- us2k12Minor allele frequency- T:0.18NA 122
    rs1498024761,2
    --4151915(+) GGACTA/GCACTG 4 -- us2k10--------
    rs351800581,2
    C--4151943(+) TTTTTT/-GAGAC 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1175769311,2
    C,F--4152070(+) GGCATG/ATGCTA 4 -- us2k11Minor allele frequency- A:0.07NA 120
    rs3508811,2
    C,F,A,H--4152097(-) aaaaaT/Aataaa 4 -- us2k18Minor allele frequency- A:0.33NS EA NA CSA 660
    rs1887551811,2
    --4152174(+) CACCTC/TGGCCT 4 -- us2k10--------
    rs729789681,2
    C,F--4152235(+) TCATCT/GGCTAA 4 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1457395491,2
    --4152381(+) AAAAAA/CAACAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREB3L3 (4153598 - 4173051 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CREB3L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717979CNV Deletion23290073
    nsv833716CNV Loss17160897
    nsv910783CNV Loss21882294
    nsv910816CNV Loss21882294
    dgv3673n71CNV Loss21882294
    nsv910818CNV Loss21882294
    nsv910817CNV Loss21882294

    Human Gene Mutation Database (HGMD): CREB3L3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB3L3
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB3L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611998    OMIM disorders: --

    18 diseases for CREB3L3:    
    About MalaCards
    hyperlipoproteinemia type v    myxoid liposarcoma    liposarcoma    thyroid adenoma
    human t-cell leukemia virus type 1    hepatocellular carcinoma    hepatoblastoma    t-cell leukemia
    huntington's disease    adenoma    thyroiditis    hiv-1
    ataxia    hepatitis b    prostate cancer    leukemia
    prostatitis    hepatitis


    CREB3L3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): CREB3L3

    Export disorders for CREB3L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREB3L3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CREB3L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver- specific expression. (PubMed id 11353085)1, 2, 3 Omori Y.... Sugano S. (Nucleic Acids Res. 2001)
    2. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. (PubMed id 16469704)1, 2 Zhang K.... Kaufman R.J. (Cell 2006)
    3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    4. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)
    5. The role of CREB-H transcription factor in triglyceride metabolism. (PubMed id 22262056)1 Lee A.H. (Curr. Opin. Lipidol. 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). (PubMed id 21994947)1 Misra J....Choi H.S. (J. Biol. Chem. 2011)
    8. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. (PubMed id 21693703)1 Chanda D....Choi H.S. (J. Biol. Chem. 2011)
    9. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (Mol. Cell. Proteomics 2011)
    10. N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H. (PubMed id 20356926)2 Chan C.P.... Jin D.Y. (J. Cell Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84699 HGNC: 18855 AceView: CREB3L3 Ensembl:ENSG00000060566 euGenes: HUgn84699
    ECgene: CREB3L3 Kegg: 84699 H-InvDB: CREB3L3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CREB3L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CREB3L3 gene:
    Search GeneIP for patents involving CREB3L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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