Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREB3L2 Gene

Aliases for CREB3L2 Gene

  • CAMP Responsive Element Binding Protein 3-Like 2 2 3
  • BBF2H7 3 4 6
  • CAMP-Responsive Element-Binding Protein 3-Like Protein 2 3 4
  • BBF2 Human Homolog On Chromosome 7 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 3
  • Basic Transcription Factor 2 3
  • B-ZIB Transcription Factor 3
  • FUS/BBF2H7 Protein 3
  • TCAG_1951439 3

External Ids for CREB3L2 Gene

Summaries for CREB3L2 Gene

Entrez Gene Summary for CREB3L2 Gene

  • This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CREB3L2 Gene

CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2) is a Protein Coding gene. Diseases associated with CREB3L2 include myxofibrosarcoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3L2 Gene

  • Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3L2 Gene

Genomics for CREB3L2 Gene

Genomic Location for CREB3L2 Gene

Start:
137,874,979 bp from pter
End:
138,002,101 bp from pter
Size:
127,123 bases
Orientation:
Minus strand

Genomic View for CREB3L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREB3L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3L2 Gene

Regulatory Elements for CREB3L2 Gene

Proteins for CREB3L2 Gene

  • Protein details for CREB3L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70SY1-CR3L2_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 2
    Protein Accession:
    Q70SY1
    Secondary Accessions:
    • Q6P454
    • Q6ZMR6

    Protein attributes for CREB3L2 Gene

    Size:
    520 amino acids
    Molecular mass:
    57415 Da
    Quaternary structure:
    • Binds DNA as a dimer.

    Alternative splice isoforms for CREB3L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3L2 Gene

Proteomics data for CREB3L2 Gene at MOPED

Post-translational modifications for CREB3L2 Gene

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys364
  • Glycosylation at Asn480, Asn504, and Asn517

Other Protein References for CREB3L2 Gene

No data available for DME Specific Peptides for CREB3L2 Gene

Domains for CREB3L2 Gene

Gene Families for CREB3L2 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CREB3L2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CR3L2_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q70SY1
Family:
  • Belongs to the bZIP family. ATF subfamily.:
    • Q70SY1
genes like me logo Genes that share domains with CREB3L2: view

Function for CREB3L2 Gene

Molecular function for CREB3L2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).

Gene Ontology (GO) - Molecular Function for CREB3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0035497 cAMP response element binding IMP 17178827
genes like me logo Genes that share ontologies with CREB3L2: view
genes like me logo Genes that share phenotypes with CREB3L2: view

Animal Models for CREB3L2 Gene

MGI Knock Outs for CREB3L2:

miRNA for CREB3L2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CREB3L2 Gene

Localization for CREB3L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3L2 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3L2 Gene COMPARTMENTS Subcellular localization image for CREB3L2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CREB3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17178827
GO:0005783 endoplasmic reticulum IDA 17178827
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CREB3L2: view

Pathways for CREB3L2 Gene

genes like me logo Genes that share pathways with CREB3L2: view

Pathways by source for CREB3L2 Gene

Gene Ontology (GO) - Biological Process for CREB3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
GO:0006986 response to unfolded protein --
genes like me logo Genes that share ontologies with CREB3L2: view

Compounds for CREB3L2 Gene

(1) HMDB Compounds for CREB3L2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with CREB3L2: view

Transcripts for CREB3L2 Gene

Unigene Clusters for CREB3L2 Gene

CAMP responsive element binding protein 3-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4:
SP5: - - -
SP6: - - - -

Relevant External Links for CREB3L2 Gene

GeneLoc Exon Structure for
CREB3L2
ECgene alternative splicing isoforms for
CREB3L2

Expression for CREB3L2 Gene

mRNA expression in normal human tissues for CREB3L2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREB3L2 Gene

SOURCE GeneReport for Unigene cluster for CREB3L2 Gene Hs.490273

mRNA Expression by UniProt/SwissProt for CREB3L2 Gene

Q70SY1-CR3L2_HUMAN
Tissue specificity: Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
genes like me logo Genes that share expressions with CREB3L2: view

Orthologs for CREB3L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3L2 36
  • 99.04 (n)
  • 99.04 (a)
CREB3L2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB3L2 36
  • 89.81 (n)
  • 93.08 (a)
CREB3L2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB3L2 37
  • 95 (a)
OneToOne
LOC491369 36
  • 90.19 (n)
  • 94.62 (a)
mouse
(Mus musculus)
Mammalia Creb3l2 36
  • 87.05 (n)
  • 91.15 (a)
Creb3l2 16
Creb3l2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB3L2 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB3L2 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb3l2 36
  • 87.24 (n)
  • 90.96 (a)
chicken
(Gallus gallus)
Aves CREB3L2 36
  • 70.74 (n)
  • 67.96 (a)
CREB3L2 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREB3L2 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3l2 36
  • 61.92 (n)
  • 54.15 (a)
zebrafish
(Danio rerio)
Actinopterygii creb3l2 36
  • 60.44 (n)
  • 56.43 (a)
creb3l2 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CrebA 37
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-2 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6977 37
  • 26 (a)
OneToMany
Species with no ortholog for CREB3L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3L2 Gene

ENSEMBL:
Gene Tree for CREB3L2 (if available)
TreeFam:
Gene Tree for CREB3L2 (if available)

Paralogs for CREB3L2 Gene

Paralogs for CREB3L2 Gene

Selected SIMAP similar genes for CREB3L2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CREB3L2: view

Variants for CREB3L2 Gene

Sequence variations from dbSNP and Humsavar for CREB3L2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9584 -- 137,875,633(-) GGGCA(A/G)GAATT utr-variant-3-prime
rs9757 -- 137,875,951(-) TCAAA(C/G)GGTCA utr-variant-3-prime
rs110595 -- 137,937,105(+) AGGGA(A/T)GCTTT intron-variant, upstream-variant-2KB
rs112417 -- 137,936,149(-) GCCCA(C/T)GCTCC intron-variant, upstream-variant-2KB
rs166661 -- 137,943,106(+) gacct(G/T)ggaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB3L2 Gene

Variant ID Type Subtype PubMed ID
esv33947 CNV Gain 17666407
nsv831150 CNV Gain+Loss 17160897
nsv518070 CNV Gain 19592680
nsv5963 CNV Insertion 18451855
esv2675854 CNV Deletion 23128226
esv28034 CNV Loss 19812545
nsv5964 CNV Loss 18451855
esv2595133 CNV Deletion 19546169
esv2735211 CNV Deletion 23290073

Relevant External Links for CREB3L2 Gene

HapMap Linkage Disequilibrium report
CREB3L2

Disorders for CREB3L2 Gene

UniProtKB/Swiss-Prot

CR3L2_HUMAN
  • Note=A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.

(1) MalaCards Diseases for CREB3L2 Gene

Search for CREB3L2 Gene in MalaCards »

(4) University of Copenhagen DISEASES for CREB3L2 Gene

(1) Novoseek inferred disease relationships for CREB3L2 Gene

Disease -log(P) Hits PubMed IDs
sarcoma 57.4 4

Relevant External Links for CREB3L2

Genetic Association Database (GAD)
CREB3L2
Human Genome Epidemiology (HuGE) Navigator
CREB3L2
genes like me logo Genes that share disorders with CREB3L2: view

Publications for CREB3L2 Gene

  1. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. (PMID: 12915480) Storlazzi C.T. … Panagopoulos I. (Hum. Mol. Genet. 2003) 3 4 23
  2. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. (PMID: 17178827) Kondo S. … Imaizumi K. (Mol. Cell. Biol. 2007) 3 4 23
  3. The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (PMID: 15139001) Panagopoulos I. … Mertens F. (Genes Chromosomes Cancer 2004) 4 23
  4. Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera. (PMID: 17117415) Panagopoulos I. … Mertens F. (Genes Chromosomes Cancer 2007) 3 23
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for CREB3L2 Gene

Sources for CREB3L2 Gene

Back to Top

Content