Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CREB3L2 Gene

protein-coding   GIFtS: 62
GCID: GC07M137559

CAMP Responsive Element Binding Protein 3-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CAMP Responsive Element Binding Protein 3-Like 21 2     B-ZIB Transcription Factor2
BBF2H72 3 5     Basic Transcription Factor 22
BBF2 Human Homolog On Chromosome 72 3     Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 22
CAMP-Responsive Element-Binding Protein 3-Like Protein 22 3     FUS/BBF2H7 Protein2
TCAG_19514392     

External Ids:    HGNC: 237201   Entrez Gene: 647642   Ensembl: ENSG000001821587   OMIM: 6088345   UniProtKB: Q70SY13   

Export aliases for CREB3L2 gene to outside databases

Previous GC identifers: GC07M136981 GC07M136975 GC07M137021 GC07M137210 GC07M131867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CREB3L2 Gene:
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but
form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on
chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CREB3L2 Gene:
CREB3L2 (cAMP responsive element binding protein 3-like 2) is a protein-coding gene. Diseases associated with CREB3L2 include myxofibrosarcoma, and ossifying fibromyxoid tumor. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB3.

UniProtKB/Swiss-Prot: CR3L2_HUMAN, Q70SY1
Function: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late
phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the
transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged
neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi
thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB3L2 gene promoter:
         AML1a   p300   Tal-1beta   E47   c-Rel   CP2   LyF-1   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): CREB3L2 promoter sequence
   Search Chromatin IP Primers for CREB3L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q34

CREB3L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3L2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M137559:  view genomic region     (about GC identifiers)

Start:
137,559,725 bp from pter      End:
137,686,846 bp from pter
Size:
127,122 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 136,905,109-137,032,068     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CR3L2_HUMAN, Q70SY1 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3-like protein 2  
Size: 520 amino acids; 57415 Da
Subunit: Binds DNA as a dimer (By similarity)
Secondary accessions: Q6P454 Q6ZMR6
Alternative splicing: 3 isoforms:  Q70SY1-1   Q70SY1-2   Q70SY1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CREB3L2: NX_Q70SY1

Explore proteomics data for CREB3L2 at MOPED

Post-translational modifications: 

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic
    transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1
    and site-2 proteases (PS1 and PS2)1
  • Ubiquitination2 at Lys364
  • Glycosylation2 at Asn480, Asn504, Asn517
  • Modification sites at PhosphoSitePlus

  • See CREB3L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240704.1  NP_919047.2  

    ENSEMBL proteins: 
     ENSP00000329140   ENSP00000403550   ENSP00000410314   ENSP00000388917   ENSP00000402889  

    CREB3L2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CREB3L2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CREB3L2
    GenScript Custom Purified and Recombinant Proteins Services for CREB3L2
    Novus Biologicals CREB3L2 Proteins
    Novus Biologicals CREB3L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CREB3L2

    CREB3L2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CREB3L2
    OriGene Custom Antibody Services for CREB3L2
    Novus Biologicals CREB3L2 Antibodies
    Abcam antibodies for CREB3L2
    Cloud-Clone Corp. Antibodies for CREB3L2
    ThermoFisher Antibodies for CREB3L2
    LSBio Antibodies in human, mouse, rat for CREB3L2

    CREB3L2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CREB3L2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CREB3L2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CREB3L2
    Cloud-Clone Corp. CLIAs for CREB3L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q70SY1

    ProtoNet protein and cluster: Q70SY1

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CR3L2_HUMAN, Q70SY1
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREB3L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR3L2_HUMAN, Q70SY1
    Function: Transcriptional activator which is processed and activated during endoplasmic reticulum stress late
    phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the
    transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged
    neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi
    thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0035497cAMP response element binding IMP17178827
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IMP17178827
         
    CREB3L2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CREB3L2:
     Decreased number of cells in m  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Creb3l2):
     craniofacial  digestive/alimentary  growth/size/body  limbs/digits/tail  mortality/aging 
     skeleton 

    CREB3L2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Creb3l2tm1Kami for CREB3L2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREB3L2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CREB3L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREB3L2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREB3L2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CREB3L2:
    hsa-mir-19b-3p (MIRT031185), hsa-mir-124-3p (MIRT002706), hsa-mir-16-5p (MIRT051241), hsa-mir-92a-3p (MIRT049799)

    Block miRNA regulation of human, mouse, rat CREB3L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB3L2 (see all 63):
    hsa-miR-3685 hsa-miR-136 hsa-miR-642a hsa-miR-562 hsa-miR-4254 hsa-miR-520f hsa-miR-765 hsa-miR-25
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CREB3L2
    Predesigned siRNA for gene silencing in human, mouse, rat CREB3L2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CREB3L2

    Clone
    Products:
         
    OriGene clones in human, mouse for CREB3L2 (see all 6)
    OriGene ORF clones in mouse, rat for CREB3L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREB3L2 (NM_194071)
    Sino Biological Human cDNA Clone for CREB3L2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREB3L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CREB3L2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CREB3L2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CR3L2_HUMAN, Q70SY1: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    CR3L2_HUMAN, Q70SY1: Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus.
    Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17178827
    GO:0005783endoplasmic reticulum IDA17178827
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    CREB3L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CREB3L2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Dopaminergic synapse0.37
    Cholinergic synapse0.37
    3Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Glioma
    Prostate cancer0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    Selected Kegg Pathways  (Kegg details for CREB3L2) (see all 17):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse


    CREB3L2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREB3L2
    Interactions:

        Search GeneGlobe Interaction Network for CREB3L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREB3L2 (Q70SY13 ENSP000003291404) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTP4A1Q930963, ENSP000003596854I2D: score=1 STRING: ENSP00000359685
    RND1Q927303, ENSP000003084614I2D: score=1 STRING: ENSP00000308461
    ZNF212Q9UDV63, ENSP000003385724I2D: score=1 STRING: ENSP00000338572
    DAXXENSP000003968764STRING: ENSP00000396876 STRING: ENSP00000266000
    CREBBPENSP000002623674STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002062chondrocyte differentiation ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006888ER to Golgi vesicle-mediated transport IEA--
    GO:0006986response to unfolded protein IEA--

    CREB3L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREB3L2 (CR3L2)

    1 HMDB Compound for CREB3L2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CREB3L2 gene (2 alternative transcripts): 
    NM_001253775.1  NM_194071.3  

    Unigene Cluster for CREB3L2:

    CAMP responsive element binding protein 3-like 2
    Hs.490273  [show with all ESTs]
    Unigene Representative Sequence: NM_194071
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330387(uc003vtv.3 uc003vtw.3) ENST00000456390(uc003vtx.2)
    ENST00000452463(uc003vty.4) ENST00000458726 ENST00000420629 ENST00000468127

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CREB3L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB3L2 (see all 63):
    hsa-miR-3685 hsa-miR-136 hsa-miR-642a hsa-miR-562 hsa-miR-4254 hsa-miR-520f hsa-miR-765 hsa-miR-25
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CREB3L2
    Predesigned siRNA for gene silencing in human, mouse, rat CREB3L2
    Clone
    Products:
         
    OriGene clones in human, mouse for CREB3L2 (see all 6)
    OriGene ORF clones in mouse, rat for CREB3L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREB3L2 (NM_194071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREB3L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L2
      QuantiTect SYBR Green Assays in human, mouse, rat CREB3L2
      QuantiFast Probe-based Assays in human, mouse, rat CREB3L2

    Additional mRNA sequence: 

    AJ549092.1 AJ549387.1 AK293048.1 AL080209.1 BC046181.1 BC063666.1 BC110813.1 BC131723.1 
    BX648300.1 BX649143.1 CR749563.1 

    20 DOTS entries:

    DT.91933479  DT.100696668  DT.101965632  DT.204213  DT.100790846  DT.100746865  DT.92053939  DT.91898223 
    DT.405778  DT.70105155  DT.100790845  DT.40287540  DT.407629  DT.95160810  DT.100790844  DT.121058745 
    DT.40206132  DT.95140218  DT.100790843  DT.91820768 

    Selected AceView cDNA sequences (see all 134):

    AI651873 AI638783 AI032468 AI962466 AA704896 AA115304 BX092349 AI262707 
    CA391461 CR749563 AI341211 AA861496 AA374818 BG012564 CD557473 AK131517 
    BF058434 BU194910 BU553910 CA422461 CK429764 AA005122 AW453050 BG236289 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
    SP1:                          -     -     -                       -                                         -                     
    SP2:                                                              -                                         -                     
    SP3:                          -     -     -                       -                                                               
    SP4:                                                                                                                              
    SP5:                          -     -     -                                                                                       


    ECgene alternative splicing isoforms for CREB3L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CREB3L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTACACTA
    CREB3L2 Expression
    About this image

    CREB3L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB3L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490273

    UniProtKB/Swiss-Prot: CR3L2_HUMAN, Q70SY1
    Tissue specificity: Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest
    levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression
    is detected in brain and heart

        Custom PCR Arrays for CREB3L2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L2
    QuantiTect SYBR Green Assays in human, mouse, rat CREB3L2
    QuantiFast Probe-based Assays in human, mouse, rat CREB3L2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CREB3L2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb3l21 , 5 cAMP responsive element binding protein 3-like 21, 5 87.05(n)1
    91.15(a)1
      6 (16.18 cM)5
    2086471  NM_178661.41  NP_848776.21 
     373272555 
    chicken
    (Gallus gallus)
    Aves CREB3L21 cAMP responsive element binding protein 3-like 2 70.74(n)
    67.96(a)
      418123  XM_416356.4  XP_416356.4 
    lizard
    (Anolis carolinensis)
    Reptilia CREB3L26
    cAMP responsive element binding protein 3-like 2
    65(a)
    1 ↔ 1
    5(16228232-16302753)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU908500.12   -- 75.28(n)    BU908500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii creb3l21 cAMP responsive element binding protein 3-like 2 60.44(n)
    56.43(a)
      791169  NM_001080651.1  NP_001074120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebA6
    Cyclic-AMP response element binding protein A
    23(a)
    1 → many
    3L(15528514-15546314)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-26
    Protein CRH-2, isoform b
    25(a)
    1 → many
    II(5179038-5187569) WBGene00016162


    ENSEMBL Gene Tree for CREB3L2 (if available)
    TreeFam Gene Tree for CREB3L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CREB3L2 gene
    CREB32  CREB3L42  CREB3L12  CREB3L32  
    2 SIMAP similar genes for CREB3L2 using alignment to 5 protein entries:     CR3L2_HUMAN (see all proteins):
    DKFZp686N2325    CREB3L1

    CREB3L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CREB3L2 (see all 2684)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669448631,2
    C--136967930(+) AAAAA-/AATTAAA 2 -- int11Minor allele frequency- AA:0.00NA 2
    rs1861465101,2
    --137559257(+) GTGCAC/TTGACC 1 -- int10--------
    rs37350151,2
    C,F,H--137559356(+) TGGCTC/TAAGTC 1 -- int114Minor allele frequency- T:0.15EA NS 3490
    rs37350161,2
    C,F,A,H--137559455(+) GACAAT/CAAAAA 1 -- int119Minor allele frequency- C:0.20EA NS WA NA 3826
    rs1905619591,2
    --137559511(+) CCGTGA/GCTGCC 1 -- int10--------
    rs1813938591,2
    --137559547(+) TTCCTC/TCAACT 1 -- int10--------
    rs752798761,2
    F--137559636(+) AAGAAC/TGGTTC 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1418039871,2
    C--137559637(+) AGAACA/GGTTCG 1 -- int10--------
    rs69778281,2
    C,F,A,H--137559690(+) TTTCAA/CATTAG 1 -- int1101Minor allele frequency- C:0.18NS EA NA PA EU CA WA 6440
    rs1505854181,2
    C--137559702(+) ACCAAA/GATTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CREB3L2 (137559725 - 137686846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CREB3L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2595133CNV Deletion19546169
    esv2675854CNV Deletion23128226
    esv2735211CNV Deletion23290073
    nsv5963CNV Insertion18451855
    esv28034CNV Loss19812545
    nsv5964CNV Loss18451855
    nsv518070CNV Gain19592680
    esv33947CNV Gain17666407
    nsv831150CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB3L2
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB3L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608834    OMIM disorders: --

    UniProtKB/Swiss-Prot: CR3L2_HUMAN, Q70SY1
  • Note=A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS).
    Translocation t(7;16)(q33;p11) with FUS

  • 19 diseases for CREB3L2:    
    About MalaCards
    myxofibrosarcoma    ossifying fibromyxoid tumor    myxoid chondrosarcoma    extraskeletal myxoid chondrosarcoma
    myxoid liposarcoma    chondrosarcoma    liposarcoma    sarcoma
    fibrosarcoma    huntington's disease    asthma    hepatitis b
    thyroiditis    prostate cancer    prostatitis    hepatitis
    multiple myeloma    myeloma    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for CREB3L2:
    Sarcoma     Myxoid liposarcoma     Extraskeletal myxoid chondrosarcoma     Fibrosarcoma

    CREB3L2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CREB3L2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma 57.4 4 17117415 (2), 12915480 (2)

    Genetic Association Database (GAD): CREB3L2
    Human Genome Epidemiology (HuGE) Navigator: CREB3L2 (2 documents)

    Export disorders for CREB3L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CREB3L2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CREB3L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer. (PubMed id 17178827)1, 2, 9 Kondo S.... Imaizumi K. (Mol. Cell. Biol. 2007)
    2. Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma. (PubMed id 12915480)1, 2, 9 Storlazzi C.T.... Panagopoulos I. (Hum. Mol. Genet. 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Characterization of the native CREB3L2 transcription factor and the FUS/CREB3L2 chimera. (PubMed id 17117415)1, 9 Panagopoulos I....Mertens F. (amp 2007)
    6. The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma. (PubMed id 15139001)2, 9 Panagopoulos I.... Mertens F. (Genes Chromosomes Cancer 2004)
    7. F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. (PubMed id 23955342)1 Yumimoto K....Nakayama K.I. (J. Biol. Chem. 2013)
    8. BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis. (PubMed id 22495181)1 Ishikura-Kinoshita S....Tsuji-Naito K. (J. Invest. Dermatol. 2012)
    9. FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. (PubMed id 21536545)1 MAPller E....Mertens F. (Clin. Cancer Res. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64764 HGNC: 23720 AceView: CREB3L2 Ensembl:ENSG00000182158 euGenes: HUgn64764
    ECgene: CREB3L2 Kegg: 64764 H-InvDB: CREB3L2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CREB3L2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CREB3L2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CREB3L2 gene:
    Search GeneIP for patents involving CREB3L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CREB3L2   OriGene RNAi products in human, mouse, rat for CREB3L2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CREB3L2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CREB3L2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CREB3L2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CREB3L2   OriGene Custom Protein Services for CREB3L2  

     
     
     Block miRNA regulation of human, mouse, rat CREB3L2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CREB3L2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L2 Predesigned siRNA for gene silencing in human, mouse, rat CREB3L2
     QuantiFast Probe-based Assays in human, mouse, rat CREB3L2 QuantiTect SYBR Green Assays in human, mouse, rat CREB3L2
     Custom PCR Arrays for CREB3L2 Search Chromatin IP Primers for CREB3L2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L2  Search GeneGlobe Interaction Network for CREB3L2
     Regulatory tfbs in CREB3L2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CREB3L2 GenScript cDNA clones with any tag delivered in your preferred vector for CREB3L2
     GenScript Custom Assay Services for CREB3L2 GenScript Custom overexpressing Cell Line Services for CREB3L2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CREB3L2 (CR3L2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CREB3L2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CREB3L2 antibodies
     CREB3L2 proteins
     CREB3L2 lysates
     Antibodies for CREB3L2
     See all of Abcam's Antibodies, Kits and Proteins for CREB3L2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CREB3L2
     Antibodies for CREB3L2
     ELISAs for CREB3L2
     CLIAs for CREB3L2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CREB3L2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CREB3L2
     SwitchGear Promoter luciferase reporter plasmids for CREB3L2
     ThermoFisher Antibodies for CREB3L2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREB3L2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CREB3L2
     LSBio Antibodies in human, mouse, rat for CREB3L2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CREB3L2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4