Aliases for CREB3L2 Gene
- CAMP Responsive Element Binding Protein 3-Like 2 2 3
- BBF2H7 3 4 6
- CAMP-Responsive Element-Binding Protein 3-Like Protein 2 3 4
- BBF2 Human Homolog On Chromosome 7 3 4
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 3
- Basic Transcription Factor 2 3
- B-ZIB Transcription Factor 3
- FUS/BBF2H7 Protein 3
- TCAG_1951439 3
External Ids for CREB3L2 Gene
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for CREB3L2 Gene
CREB3L2 (CAMP Responsive Element Binding Protein 3-Like 2) is a Protein Coding gene. Diseases associated with CREB3L2 include myxofibrosarcoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is CREB3L3.
UniProtKB/Swiss-Prot for CREB3L2 Gene
Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).