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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CREB3L1 Gene

protein-coding   GIFtS: 56
GCID: GC11P046299

CAMP Responsive Element Binding Protein 3-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CAMP Responsive Element Binding Protein 3-Like 11 2     BBF-2 Homolog (Drosophila)1
Old Astrocyte Specifically-Induced Substance2 3     BBF-2 Homolog2
OASIS2 3     Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 12
CAMP-Responsive Element-Binding Protein 3-Like Protein 12 3     

External Ids:    HGNC: 188561   Entrez Gene: 909932   Ensembl: ENSG000001576137   UniProtKB: Q96BA83   

Export aliases for CREB3L1 gene to outside databases

Previous GC identifers: GC11P046263 GC11P046256 GC11P046255 GC11P046006


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CREB3L1 Gene:
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However,
upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain
translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements.
(provided by RefSeq, Jun 2013)

GeneCards Summary for CREB3L1 Gene: 
CREB3L1 (cAMP responsive element binding protein 3-like 1) is a protein-coding gene. Diseases associated with CREB3L1 include small cell osteogenic sarcoma, and west nile virus, and among its related super-pathways are Amphetamine addiction and Circadian entrainment. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CREB3L2.

UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system
(By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and
CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREB3L1 gene promoter:
         AREB6   CREB   USF1   deltaCREB   STAT3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB3L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CREB3L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREB3L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11q11

CREB3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3L1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046299:  view genomic region     (about GC identifiers)

Start:
46,299,212 bp from pter      End:
46,342,972 bp from pter
Size:
43,761 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3-like protein 1  
Size: 519 amino acids; 57005 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Subcellular location: Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Nucleus.
Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
Sequence caution: Sequence=BAC11681.1; Type=Erroneous initiation;
Secondary accessions: Q8N2D5 Q96CP0
Alternative splicing: 2 isoforms:  Q96BA8-1   Q96BA8-2   

Explore the universe of human proteins at neXtProt for CREB3L1: NX_Q96BA8

Explore proteomics data for CREB3L1 at MOPED 

Post-translational modifications:

  • UniProtKB: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic
    transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and
    site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BA8

  • CREB3L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CREB3L1 Protein Expression
    REFSEQ proteins: NP_443086.1  
    ENSEMBL proteins: 
     ENSP00000434939   ENSP00000431677   ENSP00000436574   ENSP00000288400  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    CREB3L1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR008917 Euk_TF_DNA-bd
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry Q96BA8

    ProtoNet protein and cluster: Q96BA8

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CREB3L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR3L1_HUMAN, Q96BA8
    Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
    response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system
    (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and
    CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding IEA--
         
    CREB3L1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Creb3l1):
     cellular  growth/size  hematopoietic system  skeleton 

    CREB3L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Creb3l1tm1Kaim for CREB3L1

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CREB3L1 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Amphetamine addiction0.44
    Cocaine addiction0.44
    2Circadian entrainment
    Dopaminergic synapse0.37
    Cholinergic synapse0.37
    3Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.47
    5Glioma
    Prostate cancer0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CREB3L1
        TGF-beta Signaling Pathways


    1 BioSystems Pathway for CREB3L1
        G1 to S cell cycle control



    5/16         Kegg Pathways  (Kegg details for CREB3L1) (see all 16):
        PI3K-Akt signaling pathway
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse
    Insulin secretion


    CREB3L1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREB3L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/27 Interacting proteins for CREB3L1 (Q96BA82, 3 ENSP000002884004) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73I2D: score=1 
    ENSG00000206206Q9UER73I2D: score=1 
    ENSG00000206279Q9UER73I2D: score=1 
    ENSG00000227046Q9UER73I2D: score=1 
    ENSG00000231617Q9UER73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006986response to unfolded protein IEA--
    GO:0030500regulation of bone mineralization IEA--

    CREB3L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CREB3L1 (CR3L1)

    1 HMDB Compound for CREB3L1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Search CenterWatch for drugs/clinical trials and news about CREB3L1 / CR3L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CREB3L1 gene: 
    NM_052854.3  

    Unigene Cluster for CREB3L1:

    CAMP responsive element binding protein 3-like 1
    Hs.405961  [show with all ESTs]
    Unigene Representative Sequence: NM_052854
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529193(uc021qik.1 uc021qil.1) ENST00000534787 ENST00000527342
    ENST00000530518 ENST00000534616 ENST00000530244(uc001ncg.3) ENST00000288400

    miRNA
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    Additional mRNA sequence: 

    AB063321.1 AF055009.1 AK075538.1 AK314072.1 BC014097.1 BC015781.1 

    10 DOTS entries:

    DT.75102371  DT.97864228  DT.100778699  DT.86852998  DT.101976601  DT.100778698  DT.86841550  DT.91873360 
    DT.92064175  DT.95136072 

    24/230 AceView cDNA sequences (see all 230):

    BF055451 BM742310 BQ896801 CB146121 AI827273 BM773389 BQ955085 AW469207 
    AA316668 BU527933 BM784129 BU528167 BU527163 BQ927734 BQ954854 BF058671 
    BF195155 AW084587 AW013806 BM771593 BQ100934 BU528725 AI573165 AI739482 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CREB3L1 expression in normal human tissues (normalized intensities)      CREB3L1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CREB3L1 Expression
    About this image


    CREB3L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Testicular Interstitial Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
             skeletal muscle ; myocytes   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See CREB3L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CREB3L1

    SOURCE GeneReport for Unigene cluster: Hs.405961

    UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
    Tissue specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively
    lower levels in brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CREB3L1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb3l11 , 5 cAMP responsive element binding protein 3-like 11, 5 89.02(n)1
    92.29(a)1
      2 (50.63 cM)5
    264271  NM_011957.21  NP_036087.21 
     919823285 
    chicken
    (Gallus gallus)
    Aves LOC1008596101 cyclic AMP-responsive element-binding protein 3-like more 72.82(n)
    73.9(a)
      100859610  XM_003641390.1  XP_003641438.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB3L16
    cAMP responsive element binding protein 3-like 1
    73(a)
    1 ↔ 1
    1(42239700-42347092)
    zebrafish
    (Danio rerio)
    Actinopterygii creb3l11 cAMP responsive element binding protein 3-like 1 68.84(n)
    69.97(a)
      338317  XM_002662849.1  XP_002662895.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebA6
    Cyclic-AMP response element binding protein A
    25(a)
    1 → many
    3L(15528514-15546314)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-26
    Protein CRH-2, isoform b
    22(a)
    possible ortholog
    II(5179038-5187571)


    ENSEMBL Gene Tree for CREB3L1 (if available)
    TreeFam Gene Tree for CREB3L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CREB3L1 gene
    CREB3L22  CREB32  CREB3L42  CREB3L32  
    4 SIMAP similar genes for CREB3L1 using alignment to 3 protein entries:     CR3L1_HUMAN (see all proteins):
    CREB3L2    ATF1    EWSR1/ATF1 fusion    CREM

    CREB3L1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/837 SNPs in CREB3L1 are shown (see all 837)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734618671,2
    C,F--46223305(+) AAAGTG/AAATTG 1 -- us2k13Minor allele frequency- A:0.08WA CSA 122
    rs104376531,2
    C,F,A,H--46223409(+) ATTCTC/ACAGGA 1 -- us2k134Minor allele frequency- A:0.47NS EA NA WA CSA 3198
    rs801254341,2
    C,F--46223445(+) CAGCCT/CGGAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1412155421,2
    --46223483(+) TCAACC/TAGATC 1 -- us2k10--------
    rs1502530081,2
    --46223532(+) GGGAAC/GCAAAC 1 -- us2k10--------
    rs1911335711,2
    --46223562(+) GTATGA/CACCCT 1 -- us2k10--------
    rs1113758591,2
    F--46223643(+) AAAGGC/TCTTTG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1834591451,2
    --46223788(+) GCGATC/TGCTAT 1 -- us2k10--------
    rs778295281,2
    C,F--46223852(+) GATCCC/TGGGGC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs750080061,2
    C,F--46224552(+) CGAAAC/TTCCGT 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for CREB3L1 (46299212 - 46342972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CREB3L1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744434CNV Deletion23290073
    esv2744433CNV Deletion23290073
    nsv825867CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    9 diseases for CREB3L1:    About MalaCards
    small cell osteogenic sarcoma    west nile virus    perineurioma    huntington's disease
    fibrosarcoma    sarcoma    osteosarcoma    prostate cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for CREB3L1:
    Small cell osteogenic sarcoma     Sarcoma

    CREB3L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CREB3L1

    Export disorders for CREB3L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CREB3L1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with CREB3L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain. (PubMed id 12054625)1, 2 Omori Y.... Sugano S. (2002)
    2. EWSR1-CREB3L1 gene fusion: a novel alternative molecul ar aberration of low-grade fibromyxoid sarcoma. (PubMed id 23588368)1 Lau P.P....Chan J.K. (2013)
    3. Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells. (PubMed id 23383089)1 Miyagi H....Imaizumi K. (2013)
    4. Networks of bZIP protein-protein interactions diversif ied over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (2013)
    5. OASIS/CREB3L1 is induced by endoplasmic reticulum stre ss in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration. (PubMed id 23335989)1 Vellanki R.N....Volchuk A. (2013)
    6. Activation of OASIS family, ER stress transducers, is dependent on its stabilization. (PubMed id 22705851)1 Kondo S....Imaizumi K. (2012)
    7. FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. (PubMed id 21536545)1 MAPller E....Mertens F. (2011)
    8. A novel EWSR1-CREB3L1 fusion transcript in a case of s mall cell osteosarcoma. (PubMed id 21987447)1 Debelenko L.V....Raimondi S.C. (2011)
    9. The membrane-bound transcription factor CREB3L1 is ac tivated in response to virus infection to inhibit proliferation of virus-infect ed cells. (PubMed id 21767813)1 Denard B....Ye J. (2011)
    10. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. (PubMed id 21041443)1 Fox R.M....Andrew D.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90993 HGNC: 18856 AceView: CREB3L1 Ensembl:ENSG00000157613 euGenes: HUgn90993
    ECgene: CREB3L1 Kegg: 90993 H-InvDB: CREB3L1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CREB3L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CREB3L1 gene:
    Search GeneIP for patents involving CREB3L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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