Aliases for CREB3L1 Gene
External Ids for CREB3L1 Gene
Previous GeneCards Identifiers for CREB3L1 Gene
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
GeneCards Summary for CREB3L1 Gene
CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1) is a Protein Coding gene. Diseases associated with CREB3L1 include myxofibrosarcoma and small cell osteogenic sarcoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CREB3L3.
UniProtKB/Swiss-Prot for CREB3L1 Gene
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).