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Aliases for CREB3L1 Gene

Aliases for CREB3L1 Gene

  • CAMP Responsive Element Binding Protein 3-Like 1 2 3
  • CAMP-Responsive Element-Binding Protein 3-Like Protein 1 3 4
  • Old Astrocyte Specifically-Induced Substance 3 4
  • OASIS 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 1 3
  • BBF-2 Homolog (Drosophila) 2
  • BBF-2 Homolog 3

External Ids for CREB3L1 Gene

Summaries for CREB3L1 Gene

Entrez Gene Summary for CREB3L1 Gene

  • The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

GeneCards Summary for CREB3L1 Gene

CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1) is a Protein Coding gene. Diseases associated with CREB3L1 include small cell osteogenic sarcoma and myxofibrosarcoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3L1 Gene

  • Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3L1 Gene

Genomics for CREB3L1 Gene

Genomic Location for CREB3L1 Gene

Start:
46,277,638 bp from pter
End:
46,321,422 bp from pter
Size:
43,785 bases
Orientation:
Plus strand

Genomic View for CREB3L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREB3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3L1 Gene

Regulatory Elements for CREB3L1 Gene

Proteins for CREB3L1 Gene

  • Protein details for CREB3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BA8-CR3L1_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3-like protein 1
    Protein Accession:
    Q96BA8
    Secondary Accessions:
    • Q8N2D5
    • Q96CP0

    Protein attributes for CREB3L1 Gene

    Size:
    519 amino acids
    Molecular mass:
    57005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11681.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CREB3L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3L1 Gene

Proteomics data for CREB3L1 Gene at MOPED

Post-translational modifications for CREB3L1 Gene

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn492 and Asn513

Other Protein References for CREB3L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREB3L1 Gene

Domains for CREB3L1 Gene

Gene Families for CREB3L1 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CREB3L1 Gene

UniProtKB/Swiss-Prot:

CR3L1_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q96BA8
Family:
  • Belongs to the bZIP family. ATF subfamily.:
    • Q96BA8
genes like me logo Genes that share domains with CREB3L1: view

Function for CREB3L1 Gene

Molecular function for CREB3L1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).

Gene Ontology (GO) - Molecular Function for CREB3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS --
GO:0003677 DNA binding --
GO:0003682 chromatin binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CREB3L1: view
genes like me logo Genes that share phenotypes with CREB3L1: view

Animal Models for CREB3L1 Gene

MGI Knock Outs for CREB3L1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CREB3L1 Gene

Localization for CREB3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3L1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3L1 Gene COMPARTMENTS Subcellular localization image for CREB3L1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CREB3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005783 endoplasmic reticulum IDA 16236796
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CREB3L1: view

Pathways for CREB3L1 Gene

genes like me logo Genes that share pathways with CREB3L1: view

Pathways by source for CREB3L1 Gene

1 R&D Systems pathway for CREB3L1 Gene
1 BioSystems pathway for CREB3L1 Gene

Interacting Proteins for CREB3L1 Gene

Gene Ontology (GO) - Biological Process for CREB3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006986 response to unfolded protein --
GO:0030500 regulation of bone mineralization IEA --
genes like me logo Genes that share ontologies with CREB3L1: view

Compounds for CREB3L1 Gene

(1) HMDB Compounds for CREB3L1 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
genes like me logo Genes that share compounds with CREB3L1: view

Transcripts for CREB3L1 Gene

Unigene Clusters for CREB3L1 Gene

CAMP responsive element binding protein 3-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3L1 Gene

No ASD Table

Relevant External Links for CREB3L1 Gene

GeneLoc Exon Structure for
CREB3L1
ECgene alternative splicing isoforms for
CREB3L1

Expression for CREB3L1 Gene

mRNA expression in normal human tissues for CREB3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CREB3L1 Gene

This gene is overexpressed in Pancreas (5.1), Stomach (4.6), and Minor Salivary Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CREB3L1 Gene

SOURCE GeneReport for Unigene cluster for CREB3L1 Gene Hs.405961

mRNA Expression by UniProt/SwissProt for CREB3L1 Gene

Q96BA8-CR3L1_HUMAN
Tissue specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
genes like me logo Genes that share expressions with CREB3L1: view

Orthologs for CREB3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3L1 36
  • 99.42 (n)
  • 99.04 (a)
CREB3L1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB3L1 36
  • 91.84 (n)
  • 94.03 (a)
CREB3L1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB3L1 36
  • 93.58 (n)
  • 94.98 (a)
CREB3L1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb3l1 36
  • 89.02 (n)
  • 92.29 (a)
Creb3l1 16
Creb3l1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB3L1 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB3L1 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb3l1 36
  • 88.35 (n)
  • 91.12 (a)
chicken
(Gallus gallus)
Aves CREB3L1 37
  • 69 (a)
OneToOne
LOC100859610 36
  • 72.56 (n)
  • 73.49 (a)
lizard
(Anolis carolinensis)
Reptilia CREB3L1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3l1 36
  • 64.25 (n)
  • 65.57 (a)
zebrafish
(Danio rerio)
Actinopterygii creb3l1 36
  • 68.39 (n)
  • 68.24 (a)
creb3l1 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CrebA 37
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-2 37
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3640 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6977 37
  • 27 (a)
OneToMany
Species with no ortholog for CREB3L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3L1 Gene

ENSEMBL:
Gene Tree for CREB3L1 (if available)
TreeFam:
Gene Tree for CREB3L1 (if available)

Paralogs for CREB3L1 Gene

Paralogs for CREB3L1 Gene

Selected SIMAP similar genes for CREB3L1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CREB3L1: view

Variants for CREB3L1 Gene

Sequence variations from dbSNP and Humsavar for CREB3L1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7476 -- 46,321,284(+) GGACT(A/C)CCTGA utr-variant-3-prime
rs1044796 -- 46,321,392(+) AAAAC(C/T)AAAAA utr-variant-3-prime
rs2288249 -- 46,312,688(+) GGAGG(A/G)GTGGG intron-variant
rs2303434 -- 46,310,945(+) GGCTG(A/G)TGCAA intron-variant
rs2303435 -- 46,310,953(+) CAAGC(C/T)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB3L1 Gene

Variant ID Type Subtype PubMed ID
nsv825867 CNV Gain 20364138
esv2744433 CNV Deletion 23290073
esv2744434 CNV Deletion 23290073

Relevant External Links for CREB3L1 Gene

HapMap Linkage Disequilibrium report
CREB3L1
Human Gene Mutation Database (HGMD)
CREB3L1

Disorders for CREB3L1 Gene

(2) University of Copenhagen DISEASES for CREB3L1 Gene

Relevant External Links for CREB3L1

Genetic Association Database (GAD)
CREB3L1
genes like me logo Genes that share disorders with CREB3L1: view

No data available for UniProtKB/Swiss-Prot for CREB3L1 Gene

Publications for CREB3L1 Gene

  1. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain. (PMID: 12054625) Omori Y. … Sugano S. (Biochem. Biophys. Res. Commun. 2002) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Comprehensive identification of human bZIP interactions with coiled-coil arrays. (PMID: 12805554) Newman J.R. … Keating A.E. (Science 2003) 3
  4. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. (PMID: 16236796) Stirling J. … O'hare P. (Mol. Biol. Cell 2006) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CREB3L1 Gene

Sources for CREB3L1 Gene

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