Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CREB3L1 Gene

protein-coding   GIFtS: 57
GCID: GC11P046299

CAMP Responsive Element Binding Protein 3-Like 1

  See CREB3L1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CAMP Responsive Element Binding Protein 3-Like 11 2     BBF-2 Homolog (Drosophila)1
Old Astrocyte Specifically-Induced Substance2 3     BBF-2 Homolog2
OASIS2 3     Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 12
CAMP-Responsive Element-Binding Protein 3-Like Protein 12 3     

External Ids:    HGNC: 188561   Entrez Gene: 909932   Ensembl: ENSG000001576137   UniProtKB: Q96BA83   

Export aliases for CREB3L1 gene to outside databases

Previous GC identifers: GC11P046263 GC11P046256 GC11P046255 GC11P046006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CREB3L1 Gene:
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However,
upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain
translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements.
(provided by RefSeq, Jun 2013)

GeneCards Summary for CREB3L1 Gene:
CREB3L1 (cAMP responsive element binding protein 3-like 1) is a protein-coding gene. Diseases associated with CREB3L1 include small cell osteogenic sarcoma, and myxofibrosarcoma. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CREB3L2.

UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system
(By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and
CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB3L1 gene promoter:
         AREB6   CREB   USF1   deltaCREB   STAT3   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB3L1 promoter sequence
   Search Chromatin IP Primers for CREB3L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11q11

CREB3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3L1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P046299:  view genomic region     (about GC identifiers)

Start:
46,299,212 bp from pter      End:
46,342,972 bp from pter
Size:
43,761 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3-like protein 1  
Size: 519 amino acids; 57005 Da
Sequence caution: Sequence=BAC11681.1; Type=Erroneous initiation;
Secondary accessions: Q8N2D5 Q96CP0
Alternative splicing: 2 isoforms:  Q96BA8-1   Q96BA8-2   

Explore the universe of human proteins at neXtProt for CREB3L1: NX_Q96BA8

Explore proteomics data for CREB3L1 at MOPED

Post-translational modifications: 

  • Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic
    transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and
    site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus1
  • Glycosylation2 at Asn492, Asn513
  • Modification sites at PhosphoSitePlus

  • See CREB3L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443086.1  
    ENSEMBL proteins: 
     ENSP00000434939   ENSP00000431677   ENSP00000436574   ENSP00000288400  

    CREB3L1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CREB3L1
    OriGene Protein Over-expression Lysate for CREB3L1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CREB3L1
    GenScript Custom Purified and Recombinant Proteins Services for CREB3L1
    Novus Biologicals CREB3L1 Protein
    Novus Biologicals CREB3L1 Lysates
    Sino Biological Recombinant Protein for CREB3L1
    Sino Biological Cell Lysate for CREB3L1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CREB3L1

     
    Search eBioscience for Proteins for CREB3L1 

     
    antibodies-online proteins for CREB3L1 (3 products) 

     
    antibodies-online peptides for CREB3L1

    CREB3L1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CREB3L1 (OASIS/CREB3L1)
    OriGene Antibodies for CREB3L1
    OriGene Custom Antibody Services for CREB3L1
    Novus Biologicals CREB3L1 Antibodies
    Abcam antibodies for CREB3L1
    Cloud-Clone Corp. Antibodies for CREB3L1
    ThermoFisher Antibodies for CREB3L1
    antibodies-online antibodies for CREB3L1 (36 products) 

    CREB3L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CREB3L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CREB3L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CREB3L1
    Cloud-Clone Corp. CLIAs for CREB3L1
    Search eBioscience for ELISAs for CREB3L1 
    antibodies-online kits for CREB3L1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry Q96BA8

    ProtoNet protein and cluster: Q96BA8

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CREB3L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CR3L1_HUMAN, Q96BA8
    Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein
    response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system
    (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and
    CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with CREB3L1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Creb3l1):
     cellular  growth/size/body  hematopoietic system  skeleton 

    Find genes that share phenotypes with CREB3L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Creb3l1tm1Kaim for CREB3L1

       genOway: Develop your customized and physiologically relevant rodent model for CREB3L1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CREB3L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB3L1 (see all 21):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-449a hsa-miR-759 hsa-let-7g* hsa-miR-2116 hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCREB3L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CREB3L1
    Predesigned siRNA for gene silencing in human, mouse, rat CREB3L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CREB3L1

    Clone
    Products:
         
    OriGene clones in human, mouse for CREB3L1 (see all 7)
    OriGene ORF clones in mouse, rat for CREB3L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREB3L1 (NM_052854)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREB3L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CREB3L1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CREB3L1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12452) for CREB3L1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CR3L1_HUMAN, Q96BA8: Endoplasmic reticulum membrane; Single-pass type II membrane protein
    CR3L1_HUMAN, Q96BA8: Processed cyclic AMP-responsive element-binding protein 3-like protein 1: Nucleus.
    Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CREB3L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CREB3L1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Cocaine addiction0.44
    Amphetamine addiction0.44
    2Circadian entrainment
    Dopaminergic synapse0.37
    Cholinergic synapse0.37
    3Insulin secretion
    Insulin secretion0.36
    Thyroid hormone synthesis0.36
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Glioma
    Prostate cancer0.39


    Find genes that share SuperPaths with CREB3L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CREB3L1
        TGF-beta Signaling Pathways


    1 BioSystems Pathway for CREB3L1
        G1 to S cell cycle control



    Selected Kegg Pathways  (Kegg details for CREB3L1) (see all 17):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CREB3L1
    Interactions:

        Search GeneGlobe Interaction Network for CREB3L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CREB3L1 (Q96BA82, 3 ENSP000002884004) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73, ENSP000003968764I2D: score=1 STRING: ENSP00000396876 STRING: ENSP00000266000
    ENSG00000206279Q9UER73, ENSP000003822814I2D: score=1 STRING: ENSP00000382281
    ENSG00000227046Q9UER73, ENSP000004107724I2D: score=1 STRING: ENSP00000410772
    ENSG00000231617Q9UER73, ENSP000004046234I2D: score=1 STRING: ENSP00000404623
    ENSG00000206206Q9UER73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006986response to unfolded protein IEA--
    GO:0030500regulation of bone mineralization IEA--

    Find genes that share ontologies with CREB3L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CREB3L1 (CR3L1)

    1 HMDB Compound for CREB3L1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CREB3L1 gene: 
    NM_052854.3  

    Unigene Cluster for CREB3L1:

    CAMP responsive element binding protein 3-like 1
    Hs.405961  [show with all ESTs]
    Unigene Representative Sequence: NM_052854
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529193(uc021qik.1 uc021qil.1) ENST00000534787 ENST00000527342
    ENST00000530518 ENST00000534616 ENST00000530244(uc001ncg.3) ENST00000288400

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CREB3L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB3L1 (see all 21):
    hsa-miR-140-5p hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-449a hsa-miR-759 hsa-let-7g* hsa-miR-2116 hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCREB3L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CREB3L1
    Predesigned siRNA for gene silencing in human, mouse, rat CREB3L1
    Clone
    Products:
         
    OriGene clones in human, mouse for CREB3L1 (see all 7)
    OriGene ORF clones in mouse, rat for CREB3L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CREB3L1 (NM_052854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CREB3L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CREB3L1
    OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L1
      QuantiTect SYBR Green Assays in human, mouse, rat CREB3L1
      QuantiFast Probe-based Assays in human, mouse, rat CREB3L1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12452) for CREB3L1 

    Additional mRNA sequence: 

    AB063321.1 AF055009.1 AK075538.1 AK314072.1 BC014097.1 BC015781.1 

    10 DOTS entries:

    DT.75102371  DT.97864228  DT.100778699  DT.86852998  DT.101976601  DT.100778698  DT.86841550  DT.91873360 
    DT.92064175  DT.95136072 

    Selected AceView cDNA sequences (see all 230):

    AI537605 BU527933 BM784129 BU528167 BU527163 BQ927734 BQ954854 BF058671 
    BF195155 AW084587 AW013806 BM771593 BQ100934 BU528725 AA976253 BE772637 
    AI860590 AI827273 BM773389 BQ955085 AW469207 AA316668 BF058965 BC015781 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CREB3L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CREB3L1 Expression
    About this image


    CREB3L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Long Bone
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    CREB3L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB3L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405961

    UniProtKB/Swiss-Prot: CR3L1_HUMAN, Q96BA8
    Tissue specificity: Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively
    lower levels in brain

        Custom PCR Arrays for CREB3L1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CREB3L1
    OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L1
    QuantiTect SYBR Green Assays in human, mouse, rat CREB3L1
    QuantiFast Probe-based Assays in human, mouse, rat CREB3L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CREB3L1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb3l11 , 5 cAMP responsive element binding protein 3-like 11, 5 89.02(n)1
    92.29(a)1
      2 (50.63 cM)5
    264271  NM_011957.21  NP_036087.21 
     919823285 
    chicken
    (Gallus gallus)
    Aves LOC1008596101 cyclic AMP-responsive element-binding protein 3-like more 72.56(n)
    73.49(a)
      100859610  XM_004941610.1  XP_004941667.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB3L16
    cAMP responsive element binding protein 3-like 1
    73(a)
    1 ↔ 1
    1(42239700-42347092)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia creb3l11 cAMP responsive element binding protein 3-like 1 64.25(n)
    65.57(a)
      100496679  XM_002934095.2  XP_002934141.2 
    zebrafish
    (Danio rerio)
    Actinopterygii creb3l11 cAMP responsive element binding protein 3-like 1 68.39(n)
    68.24(a)
      338317  NM_001243038.1  NP_001229967.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebA6
    Cyclic-AMP response element binding protein A
    24(a)
    1 → many
    3L(15528514-15546314)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-26
    Protein CRH-2, isoform b
    24(a)
    1 → many
    II(5179038-5187569) WBGene00016162


    ENSEMBL Gene Tree for CREB3L1 (if available)
    TreeFam Gene Tree for CREB3L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CREB3L1 gene
    CREB3L22  CREB32  CREB3L42  CREB3L32  
    4 SIMAP similar genes for CREB3L1 using alignment to 3 protein entries:     CR3L1_HUMAN (see all proteins):
    CREB3L2    ATF1    EWSR1/ATF1 fusion    CREM

    Find genes that share paralogs with CREB3L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CREB3L1 (see all 837)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734618671,2
    C,F--46223305(+) AAAGTG/AAATTG 1 -- us2k13Minor allele frequency- A:0.08WA CSA 122
    rs104376531,2
    C,F,A,H--46223409(+) ATTCTC/ACAGGA 1 -- us2k134Minor allele frequency- A:0.47NS EA NA WA CSA 3198
    rs801254341,2
    C,F--46223445(+) CAGCCT/CGGAAG 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1412155421,2
    --46223483(+) TCAACC/TAGATC 1 -- us2k10--------
    rs1502530081,2
    --46223532(+) GGGAAC/GCAAAC 1 -- us2k10--------
    rs1911335711,2
    --46223562(+) GTATGA/CACCCT 1 -- us2k10--------
    rs1113758591,2
    F--46223643(+) AAAGGC/TCTTTG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1834591451,2
    --46223788(+) GCGATC/TGCTAT 1 -- us2k10--------
    rs778295281,2
    C,F--46223852(+) GATCCC/TGGGGC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs750080061,2
    C,F--46224552(+) CGAAAC/TTCCGT 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for CREB3L1 (46299212 - 46342972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CREB3L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744434CNV Deletion23290073
    esv2744433CNV Deletion23290073
    nsv825867CNV Gain20364138

    Human Gene Mutation Database (HGMD): CREB3L1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB3L1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB3L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    4 diseases for CREB3L1:    
    About MalaCards
    small cell osteogenic sarcoma    myxofibrosarcoma    osteogenesis imperfecta type iii    west nile virus

    2 diseases from the University of Copenhagen DISEASES database for CREB3L1:
    Small cell osteogenic sarcoma     Sarcoma

    Find genes that share disorders with CREB3L1           About GenesLikeMe

    Genetic Association Database (GAD): CREB3L1

    Export disorders for CREB3L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CREB3L1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CREB3L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain. (PubMed id 12054625)1, 2 Omori Y.... Sugano S. (Biochem. Biophys. Res. Commun. 2002)
    2. EWSR1-CREB3L1 gene fusion: a novel alternative molecular aberration of low-grade fibromyxoid sarcoma. (PubMed id 23588368)1 Lau P.P....Chan J.K. (Am. J. Surg. Pathol. 2013)
    3. Transcriptional regulation of VEGFA by the endoplasmic reticulum stress transducer OASIS in ARPE-19 cells. (PubMed id 23383089)1 Miyagi H....Imaizumi K. (PLoS ONE 2013)
    4. F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. (PubMed id 23955342)1 Yumimoto K....Nakayama K.I. (J. Biol. Chem. 2013)
    5. CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis. (PubMed id 24126059)1 Mellor P....Anderson D.H. (Mol. Cell. Biol. 2013)
    6. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)
    7. OASIS/CREB3L1 is induced by endoplasmic reticulum stress in human glioma cell lines and contributes to the unfolded protein response, extracellular matrix production and cell migration. (PubMed id 23335989)1 Vellanki R.N....Volchuk A. (PLoS ONE 2013)
    8. Activation of OASIS family, ER stress transducers, is dependent on its stabilization. (PubMed id 22705851)1 Kondo S....Imaizumi K. (Cell Death Differ. 2012)
    9. FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1. (PubMed id 21536545)1 MAPller E....Mertens F. (Clin. Cancer Res. 2011)
    10. A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma. (PubMed id 21987447)1 Debelenko L.V....Raimondi S.C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 90993 HGNC: 18856 AceView: CREB3L1 Ensembl:ENSG00000157613 euGenes: HUgn90993
    ECgene: CREB3L1 Kegg: 90993 H-InvDB: CREB3L1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CREB3L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CREB3L1 gene:
    Search GeneIP for patents involving CREB3L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CREB3L1 (OASIS/CREB3L1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CREB3L1   OriGene RNAi products in human, mouse, rat for CREB3L1  
     OriGene qPCR primer pairs and template standards for CREB3L1   OriGene Protein Over-expression Lysate for CREB3L1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CREB3L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CREB3L1   OriGene Purified Protein for CREB3L1  
     OriGene ORF clones in mouse, rat for CREB3L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CREB3L1   OriGene Custom Protein Services for CREB3L1  

     
     
     Block miRNA regulation of human, mouse, rat CREB3L1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CREB3L1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3L1 Predesigned siRNA for gene silencing in human, mouse, rat CREB3L1
     QuantiFast Probe-based Assays in human, mouse, rat CREB3L1 QuantiTect SYBR Green Assays in human, mouse, rat CREB3L1
     Custom PCR Arrays for CREB3L1 Search Chromatin IP Primers for CREB3L1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CREB3L1  Search GeneGlobe Interaction Network for CREB3L1
     Regulatory tfbs in CREB3L1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CREB3L1 GenScript cDNA clones with any tag delivered in your preferred vector for CREB3L1
     GenScript Custom Assay Services for CREB3L1 GenScript Custom overexpressing Cell Line Services for CREB3L1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CREB3L1 (CR3L1)
     Proteins for CREB3L1
     Cell Lysates for CREB3L1
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CREB3L1 antibodies
     CREB3L1 proteins
     CREB3L1 lysates
     Antibodies for CREB3L1
     See all of Abcam's Antibodies, Kits and Proteins for CREB3L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CREB3L1
     Antibodies for CREB3L1
     ELISAs for CREB3L1
     CLIAs for CREB3L1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CREB3L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3L1
     SwitchGear 3'UTR luciferase reporter plasmids for CREB3L1
     SwitchGear Promoter luciferase reporter plasmids for CREB3L1
     ThermoFisher Antibodies for CREB3L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3L1
     Browse compounds at ApexBio
     Search Addgene for plasmids for CREB3L1
      Search eBioscience for proteins for CREB3L1
      Search eBioscience for elisas for CREB3L1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CREB3L1
     antibodies-online antibodies for CREB3L1 (36 products)
     antibodies-online kits for CREB3L1 (6 products)
     antibodies-online peptides for CREB3L1
     antibodies-online proteins for CREB3L1 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CREB3L1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4