Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREB3 Gene

Aliases for CREB3 Gene

  • CAMP Responsive Element Binding Protein 3 2 3
  • LZIP 3 4 6
  • CAMP-Responsive Element-Binding Protein 3 3 4
  • Transcription Factor LZIP-Alpha 3 4
  • Small Leucine Zipper Protein 2 3
  • Leucine Zipper Protein 3 4
  • CREB-3 3 4
  • LUMAN 3 4
  • Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1 3
  • CAMP Responsive Element Binding Protein 3 (Luman) 2
  • Cyclic AMP-Responsive Element-Binding Protein 3 3
  • Basic Leucine Zipper Protein 3
  • Leucin Zipper Proitein 3
  • SLZIP 3

External Ids for CREB3 Gene

Summaries for CREB3 Gene

Entrez Gene Summary for CREB3 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for CREB3 Gene

CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. Diseases associated with CREB3 include human t-cell leukemia virus type 1 and herpes simplex. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3 Gene

  • Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells

  • Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter

Gene Wiki entry for CREB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3 Gene

Genomics for CREB3 Gene

Genomic Location for CREB3 Gene

Start:
35,732,320 bp from pter
End:
35,737,008 bp from pter
Size:
4,689 bases
Orientation:
Plus strand

Genomic View for CREB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3 Gene

Regulatory Elements for CREB3 Gene

Proteins for CREB3 Gene

  • Protein details for CREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43889-CREB3_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3
    Protein Accession:
    O43889
    Secondary Accessions:
    • D0PTW6
    • O14671
    • O14919
    • Q5TCV1
    • Q96GK8
    • Q9H2W3
    • Q9UE77

    Protein attributes for CREB3 Gene

    Size:
    395 amino acids
    Molecular mass:
    43917 Da
    Quaternary structure:
    • Homodimer; homodimerization is prevented by the HCV core protein. Interacts with HCFC1; the interaction is required to stimulate CREB3 transcriptional activity. Isoform 2 interacts with CREBZF; the interaction occurs only in combination with HCFC1. Isoform 2 interacts (via central part and transmembrane region) with TM7SF4 (via C-terminus cytoplasmic domain). Isoform 2 interacts with OS9. Isoform 2 interacts (via leucine-zipper domain) with CREBRF (via leucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3 degradation. Isoform 2 interacts (via C-terminal domain) with CCR1. Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 ENV (via cytoplasmic domain). Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability. Interacts with the HCV core protein. Processed cyclic AMP-responsive element-binding protein 3 interacts with HIV-1 Tat.

    Alternative splice isoforms for CREB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3 Gene

Proteomics data for CREB3 Gene at MOPED

Post-translational modifications for CREB3 Gene

  • N-glycosylated.
  • The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF4
  • The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys376
  • Glycosylation at Asn331 and Asn372

Other Protein References for CREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREB3 Gene

Domains for CREB3 Gene

Gene Families for CREB3 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CREB3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CREB3_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • O43889
Family:
  • Belongs to the bZIP family. ATF subfamily.:
    • O43889
genes like me logo Genes that share domains with CREB3: view

Function for CREB3 Gene

Molecular function for CREB3 Gene

UniProtKB/Swiss-Prot Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells
UniProtKB/Swiss-Prot Function: Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter
UniProtKB/Swiss-Prot Induction: Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated upon DC maturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin (Tm). Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by NF-kappa-B.

Gene Ontology (GO) - Molecular Function for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 15845366
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16940180
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA 16940180
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 16940180
GO:0003677 DNA binding IDA 10675342
genes like me logo Genes that share ontologies with CREB3: view

miRNA for CREB3 Gene

miRTarBase miRNAs that target CREB3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CREB3 Gene

Localization for CREB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3 Gene

Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein. {ECO:0000250}.
Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus.
Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3 Gene COMPARTMENTS Subcellular localization image for CREB3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 20091349
GO:0005634 nucleus IDA 10675342
GO:0005737 cytoplasm IMP 10623756
GO:0005783 endoplasmic reticulum IMP 10623756
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with CREB3: view

Pathways for CREB3 Gene

genes like me logo Genes that share pathways with CREB3: view

Gene Ontology (GO) - Biological Process for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 20141198
GO:0002230 positive regulation of defense response to virus by host IDA 20091349
GO:0006351 transcription, DNA-templated IDA 9271389
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 16940180
genes like me logo Genes that share ontologies with CREB3: view

Compounds for CREB3 Gene

(1) HMDB Compounds for CREB3 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(10) Novoseek inferred chemical compound relationships for CREB3 Gene

Compound -log(P) Hits PubMed IDs
leucine 82.8 53
sterol 41.1 3
cyclic amp 39.9 5
tunicamycin 32.7 1
tetrapeptide 31.8 2
genes like me logo Genes that share compounds with CREB3: view

Transcripts for CREB3 Gene

mRNA/cDNA for CREB3 Gene

Unigene Clusters for CREB3 Gene

CAMP responsive element binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3 Gene

No ASD Table

Relevant External Links for CREB3 Gene

GeneLoc Exon Structure for
CREB3
ECgene alternative splicing isoforms for
CREB3

Expression for CREB3 Gene

mRNA expression in normal human tissues for CREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CREB3 Gene Hs.522110

mRNA Expression by UniProt/SwissProt for CREB3 Gene

O43889-CREB3_HUMAN
Tissue specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous.
genes like me logo Genes that share expressions with CREB3: view

Orthologs for CREB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB3 36
  • 82.88 (n)
  • 76.1 (a)
CREB3 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB3 36
  • 83.48 (n)
  • 77.31 (a)
CREB3 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb3 36
  • 76.26 (n)
  • 68.77 (a)
Creb3 16
Creb3 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB3 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB3 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb3 36
  • 72.92 (n)
  • 58.59 (a)
chicken
(Gallus gallus)
Aves CREB3 36
  • 60.64 (n)
  • 55.72 (a)
CREB3 37
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREB3 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16347 36
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3 36
  • 59.45 (n)
  • 52.76 (a)
zebrafish
(Danio rerio)
Actinopterygii creb3l3l 36
  • 59.76 (n)
  • 52.02 (a)
creb3l3l 37
  • 28 (a)
OneToOne
wufj05f07 36
worm
(Caenorhabditis elegans)
Secernentea let-607 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for CREB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3 Gene

ENSEMBL:
Gene Tree for CREB3 (if available)
TreeFam:
Gene Tree for CREB3 (if available)

Paralogs for CREB3 Gene

Paralogs for CREB3 Gene

genes like me logo Genes that share paralogs with CREB3: view

Variants for CREB3 Gene

Sequence variations from dbSNP and Humsavar for CREB3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2181028 -- 35,734,906(+) ACCAG(G/T)TTTTT intron-variant
rs2381399 -- 35,735,798(+) ATATT(C/T)GCAAA intron-variant
rs10814274 -- 35,734,959(+) TGGTC(C/T)GTGGA intron-variant
rs12339916 -- 35,736,201(+) CCTTC(C/T)TCATC intron-variant
rs12352355 -- 35,735,998(+) TGTCT(C/T)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB3 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294
esv25437 CNV Loss 19812545

Relevant External Links for CREB3 Gene

HapMap Linkage Disequilibrium report
CREB3
Human Gene Mutation Database (HGMD)
CREB3

Disorders for CREB3 Gene

(3) Novoseek inferred disease relationships for CREB3 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 64.1 4
herpes simplex 42.5 2
tumors 0 1

Relevant External Links for CREB3

Genetic Association Database (GAD)
CREB3
Human Genome Epidemiology (HuGE) Navigator
CREB3
genes like me logo Genes that share disorders with CREB3: view

No data available for UniProtKB/Swiss-Prot for CREB3 Gene

Publications for CREB3 Gene

  1. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PMID: 9271389) Lu R. … Misra V. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. (PMID: 9389645) Freiman R.N. … Herr W. (Genes Dev. 1997) 3 4 23
  3. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PMID: 10629049) Mahajan S.S. … Wilson A.C. (Mol. Cell. Biol. 2000) 3 4 23
  4. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PMID: 15001559) Ko J. … Na D.S. (FASEB J. 2004) 3 4 23
  5. N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. (PMID: 10984507) Luciano R.L. … Wilson A.C. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23

Products for CREB3 Gene

  • Addgene plasmids for CREB3

Sources for CREB3 Gene

Back to Top

Content