Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CREB3 Gene

Aliases for CREB3 Gene

  • CAMP Responsive Element Binding Protein 3 2 3 5
  • CAMP-Responsive Element-Binding Protein 3 3 4
  • Transcription Factor LZIP-Alpha 3 4
  • Small Leucine Zipper Protein 2 3
  • Leucine Zipper Protein 3 4
  • CREB-3 3 4
  • LUMAN 3 4
  • LZIP 3 4
  • Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1 3
  • CAMP Responsive Element Binding Protein 3 (Luman) 2
  • Basic Leucine Zipper Protein 3
  • Leucin Zipper Proitein 3
  • SLZIP 3

External Ids for CREB3 Gene

Previous GeneCards Identifiers for CREB3 Gene

  • GC09P036044
  • GC09P035901

Summaries for CREB3 Gene

Entrez Gene Summary for CREB3 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for CREB3 Gene

CREB3 (CAMP Responsive Element Binding Protein 3) is a Protein Coding gene. Diseases associated with CREB3 include herpes simplex and scarlet fever. Among its related pathways are cAMP signaling pathway and Insulin secretion. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is CREB3L3.

UniProtKB/Swiss-Prot for CREB3 Gene

  • Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.

  • Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter.

Gene Wiki entry for CREB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB3 Gene

Genomics for CREB3 Gene

Regulatory Elements for CREB3 Gene

Genomic Location for CREB3 Gene

Chromosome:
9
Start:
35,732,320 bp from pter
End:
35,737,008 bp from pter
Size:
4,689 bases
Orientation:
Plus strand

Genomic View for CREB3 Gene

Genes around CREB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CREB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CREB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB3 Gene

Proteins for CREB3 Gene

  • Protein details for CREB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43889-CREB3_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 3
    Protein Accession:
    O43889
    Secondary Accessions:
    • D0PTW6
    • O14671
    • O14919
    • Q5TCV1
    • Q96GK8
    • Q9H2W3
    • Q9UE77

    Protein attributes for CREB3 Gene

    Size:
    395 amino acids
    Molecular mass:
    43917 Da
    Quaternary structure:
    • Homodimer; homodimerization is prevented by the HCV core protein. Interacts with HCFC1; the interaction is required to stimulate CREB3 transcriptional activity. Isoform 2 interacts with CREBZF; the interaction occurs only in combination with HCFC1. Isoform 2 interacts (via central part and transmembrane region) with TM7SF4 (via C-terminus cytoplasmic domain). Isoform 2 interacts with OS9. Isoform 2 interacts (via leucine-zipper domain) with CREBRF (via leucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3 degradation. Isoform 2 interacts (via C-terminal domain) with CCR1. Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 ENV (via cytoplasmic domain). Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1 TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability. Interacts with the HCV core protein. Processed cyclic AMP-responsive element-binding protein 3 interacts with HIV-1 Tat.

    Alternative splice isoforms for CREB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB3 Gene

Proteomics data for CREB3 Gene at MOPED

Post-translational modifications for CREB3 Gene

  • N-glycosylated.
  • The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF4.
  • The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded.
  • Ubiquitination at Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for CREB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CREB3 Gene

Domains & Families for CREB3 Gene

Gene Families for CREB3 Gene

Protein Domains for CREB3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CREB3 Gene

Graphical View of Domain Structure for InterPro Entry

O43889

UniProtKB/Swiss-Prot:

CREB3_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. ATF subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. ATF subfamily.
genes like me logo Genes that share domains with CREB3: view

Function for CREB3 Gene

Molecular function for CREB3 Gene

UniProtKB/Swiss-Prot Function:
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.
UniProtKB/Swiss-Prot Function:
Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. Its transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3) and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites. Binds DNA to the 5-CCAC[GA]-3half of ERSE II (5-ATTGG-N-CCACG-3). Associates with chromatin to the HERPUD1 promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated upon DC maturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin (Tm). Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by NF-kappa-B.

Gene Ontology (GO) - Molecular Function for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 16940180
GO:0042803 protein homodimerization activity IDA 10675342
GO:0043565 sequence-specific DNA binding IEA --
GO:0046983 protein dimerization activity TAS 10623756
genes like me logo Genes that share ontologies with CREB3: view
genes like me logo Genes that share phenotypes with CREB3: view

Animal Model Products

CRISPR Products

miRNA for CREB3 Gene

miRTarBase miRNAs that target CREB3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CREB3 Gene

Localization for CREB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB3 Gene

Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein. {ECO:0000250}.
Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus.
Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB3 Gene COMPARTMENTS Subcellular localization image for CREB3 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 20091349
GO:0005829 cytosol IMP 15001559
GO:0030176 integral component of endoplasmic reticulum membrane IDA 20546900
genes like me logo Genes that share ontologies with CREB3: view

Pathways & Interactions for CREB3 Gene

genes like me logo Genes that share pathways with CREB3: view

SIGNOR curated interactions for CREB3 Gene

Activates:

Gene Ontology (GO) - Biological Process for CREB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 20141198
GO:0006935 chemotaxis IEA --
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IDA 16940180
GO:0016032 viral process IEA --
GO:0030335 positive regulation of cell migration IMP 15001559
genes like me logo Genes that share ontologies with CREB3: view

Drugs & Compounds for CREB3 Gene

(5) Drugs for CREB3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(5) Additional Compounds for CREB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CREB3: view

Transcripts for CREB3 Gene

mRNA/cDNA for CREB3 Gene

Unigene Clusters for CREB3 Gene

CAMP responsive element binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREB3 Gene

No ASD Table

Relevant External Links for CREB3 Gene

GeneLoc Exon Structure for
CREB3
ECgene alternative splicing isoforms for
CREB3

Expression for CREB3 Gene

mRNA expression in normal human tissues for CREB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CREB3 Gene Hs.522110

mRNA Expression by UniProt/SwissProt for CREB3 Gene

O43889-CREB3_HUMAN
Tissue specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous.
genes like me logo Genes that share expression patterns with CREB3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CREB3 Gene

Orthologs for CREB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB3 36
  • 75 (a)
OneToOne
CREB3 35
  • 82.88 (n)
  • 76.1 (a)
dog
(Canis familiaris)
Mammalia CREB3 35
  • 83.48 (n)
  • 77.31 (a)
CREB3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb3 36
  • 66 (a)
OneToOne
Creb3 16
Creb3 35
  • 76.26 (n)
  • 68.77 (a)
oppossum
(Monodelphis domestica)
Mammalia CREB3 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB3 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb3 35
  • 72.92 (n)
  • 58.59 (a)
chicken
(Gallus gallus)
Aves CREB3 36
  • 27 (a)
OneToOne
CREB3 35
  • 60.64 (n)
  • 55.72 (a)
lizard
(Anolis carolinensis)
Reptilia CREB3 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16347 35
tropical clawed frog
(Silurana tropicalis)
Amphibia creb3 35
  • 59.45 (n)
  • 52.76 (a)
zebrafish
(Danio rerio)
Actinopterygii creb3l3l 36
  • 28 (a)
OneToOne
creb3l3l 35
  • 59.76 (n)
  • 52.02 (a)
wufj05f07 35
worm
(Caenorhabditis elegans)
Secernentea let-607 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for CREB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB3 Gene

ENSEMBL:
Gene Tree for CREB3 (if available)
TreeFam:
Gene Tree for CREB3 (if available)

Paralogs for CREB3 Gene

Paralogs for CREB3 Gene

genes like me logo Genes that share paralogs with CREB3: view

Variants for CREB3 Gene

Sequence variations from dbSNP and Humsavar for CREB3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2181028 -- 35,734,906(+) ACCAG(G/T)TTTTT intron-variant
rs12339916 -- 35,736,201(+) CCTTC(C/T)TCATC intron-variant
rs17850501 -- 35,736,268(+) GCTAT(G/T)TACTC reference, missense
rs34745689 -- 35,736,102(-) GTTTT(A/G)TTTGA reference, synonymous-codon
rs137928808 -- 35,735,130(+) TGAAA(C/T)GTGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CREB3 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294
esv25437 CNV Loss 19812545

Variation tolerance for CREB3 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CREB3 Gene

HapMap Linkage Disequilibrium report
CREB3
Human Gene Mutation Database (HGMD)
CREB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREB3 Gene

Disorders for CREB3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CREB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
scarlet fever
  • scarlatina
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search CREB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CREB3

Genetic Association Database (GAD)
CREB3
Human Genome Epidemiology (HuGE) Navigator
CREB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CREB3
genes like me logo Genes that share disorders with CREB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CREB3 Gene

Publications for CREB3 Gene

  1. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PMID: 9271389) Lu R. … Misra V. (Mol. Cell. Biol. 1997) 2 3 4 23 67
  2. A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. (PMID: 19779205) Kang H. … Ko J. (Mol. Endocrinol. 2009) 3 23
  3. Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines. (PMID: 17192849) Jang S.W. … Ko J. (J. Cell. Physiol. 2007) 3 23
  4. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. (PMID: 17296613) Jang S.W. … Ko J. (J. Biol. Chem. 2007) 3 23
  5. CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. (PMID: 16236796) Stirling J. … O'hare P. (Mol. Biol. Cell 2006) 3 23

Products for CREB3 Gene

Sources for CREB3 Gene

Back to Top

Content