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CREB3 Gene

protein-coding   GIFtS: 59
GCID: GC09P035722

CAMP Responsive Element Binding Protein 3

(Previous name: cAMP responsive element binding protein 3 (luman))
  See CREB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Binding Protein 31 2     LUMAN2
LZIP2 3 5     Basic Leucine Zipper Protein2
Leucine Zipper Protein2 3     Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription
Factor 12
Transcription Factor LZIP-Alpha2 3     Cyclic AMP-Responsive Element-Binding Protein 32
CREB-32 3     Leucin Zipper Proitein2
CAMP-Responsive Element-Binding Protein 32 3     Luman3
CAMP Responsive Element Binding Protein 3 (Luman)1     

External Ids:    HGNC: 23471   Entrez Gene: 104882   Ensembl: ENSG000001071757   OMIM: 6064435   UniProtKB: O438893   

Export aliases for CREB3 gene to outside databases

Previous GC identifers: GC09P036044 GC09P035901


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREB3 Gene:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins.
This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host
cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription
of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is
thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of
latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and
endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified,
but their biological validity has not been determined.(provided by RefSeq, Nov 2009)

GeneCards Summary for CREB3 Gene:
CREB3 (cAMP responsive element binding protein 3) is a protein-coding gene. Diseases associated with CREB3 include human t-cell leukemia virus type 1, and herpes simplex. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CREB3L2.

UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889
Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response
(UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays
also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex
virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein
response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte
cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C
virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the
HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the
initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative
transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by
recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation
level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells
Function: Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates
unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell
survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and
C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates
transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent
transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It's transcriptional activity is inhibited by
CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds
DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many
viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites.
Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1
promoter

Gene Wiki entry for CREB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB3 gene promoter:
         C/EBPbeta   AP-1   Pax-6   ATF-2   STAT5A   c-Ets-1   C/EBPalpha   HEN1   ZID   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB3 promoter sequence
   Search Chromatin IP Primers for CREB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

CREB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P035722:  view genomic region     (about GC identifiers)

Start:
35,732,317 bp from pter      End:
35,737,005 bp from pter
Size:
4,689 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 3  
Size: 395 amino acids; 43917 Da
Subunit: Homodimer; homodimerization is prevented by the HCV core protein. Interacts with HCFC1; the interaction
is required to stimulate CREB3 transcriptional activity. Isoform 2 interacts with CREBZF; the interaction occurs
only in combination with HCFC1. Isoform 2 interacts (via central part and transmembrane region) with TM7SF4 (via
C-terminus cytoplasmic domain). Isoform 2 interacts with OS9. Isoform 2 interacts (via leucine-zipper domain)
with CREBRF (via leucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3
degradation. Isoform 2 interacts (via C-terminal domain) with CCR1. Isoform 2 interacts (via leucine-zipper and
transmembrane domains) with HIV-1 ENV (via cytoplasmic domain). Isoform 2 interacts (via leucine-zipper and
transmembrane domains) with HIV-1 TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability.
Interacts with the HCV core protein. Processed cyclic AMP-responsive element-binding protein 3 interacts with
HIV-1 Tat
Caution: All experiments concerning the proteolytic cleavage are done with isoform 2
Secondary accessions: D0PTW6 O14671 O14919 Q5TCV1 Q96GK8 Q9H2W3 Q9UE77
Alternative splicing: 3 isoforms:  O43889-1   O43889-2   O43889-3   (Does not contain a helical transmembrane domain)

Explore the universe of human proteins at neXtProt for CREB3: NX_O43889

Explore proteomics data for CREB3 at MOPED

Post-translational modifications: 

  • The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved by
    site-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. The
    membrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P)
    through a regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic
    AMP-responsive element-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is
    strongly induced during dendritic cell (DC) maturation and inhibited by TM7SF41
  • The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded1
  • N-glycosylated1
  • Ubiquitination2 at Lys376
  • Glycosylation2 at Asn331, Asn372
  • Modification sites at PhosphoSitePlus

  • See CREB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006359.3  
    ENSEMBL proteins: 
     ENSP00000342136  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry O43889

    ProtoNet protein and cluster: O43889

    1 Blocks protein domain: IPB011616 bZIP transcription factor

    UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CREB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREB3_HUMAN, O43889
    Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response
    (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays
    also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex
    virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein
    response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte
    cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C
    virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the
    HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the
    initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative
    transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by
    recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation
    level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells
    Function: Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates
    unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell
    survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and
    C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates
    transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent
    transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It's transcriptional activity is inhibited by
    CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds
    DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many
    viral and cellular promoters. Binds to the unfolded protein respons element (UPRE) consensus sequences sites.
    Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II (5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1
    promoter
    Induction: Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated
    upon DC maturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin
    (Tm). Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by
    NF-kappa-B

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA15845366
    GO:0003677DNA binding IDA10675342
    GO:0003682chromatin binding IDA16940180
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI10629049
         
    Find genes that share ontologies with CREB3           About GenesLikeMe


    Animal Models:
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    miRNA
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    hsa-miR-203 hsa-miR-3667-5p hsa-miR-3650 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidCREB3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREB3_HUMAN, O43889: Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane.
    Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with
    TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane.
    Sequestred into the cytoplasm by the HCV core protein
    CREB3_HUMAN, O43889: Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus
    CREB3_HUMAN, O43889: Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation
    the transcriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the
    nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in
    nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA--
    GO:0005634nucleus IDA10675342
    GO:0005737cytoplasm IMP10623756
    GO:0005783endoplasmic reticulum IMP10623756
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with CREB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREB3 About   (see all 40)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    2CREB Pathway
    CREB Pathway0.68
    Activation of PKC through GPCR0.63
    IP3 Pathway0.68
    Intracellular Calcium Signaling0.50
    3GPCR Pathway
    GPCR Pathway0.62
    P2Y Receptor Signaling0.38
    Estrogen Pathway0.55
    4ERK Signaling
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5ErbB4 Pathway
    LPS Stimulated MAPK Signaling0.47
    PI3K Signaling in B-Lymphocyte0.35
    PACAP Signaling0.37


    Find genes that share SuperPaths with CREB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CREB3 (see all 45)
        FLT3 Signaling
    Nuclear Receptor Activation by Vitamin-A
    Toll-Like Receptors Pathway
    Interferon Pathway
    Intracellular Calcium Signaling

    2 BioSystems Pathways for CREB3
        Myometrial Relaxation and Contraction Pathways
    G1 to S cell cycle control



    Selected Kegg Pathways  (Kegg details for CREB3) (see all 17):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    TNF signaling pathway
    Cholinergic synapse
    Dopaminergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CREB3: 
              Circadian Rhythms in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CREB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREB3 (O438891, 2, 3 ENSP000003421364) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX8Q9UNK02, 3, ENSP000003052554MINT-66240 I2D: score=6 STRING: ENSP00000305255
    APPBP2Q926242, 3, ENSP000000831824MINT-66791 I2D: score=5 STRING: ENSP00000083182
    MALLQ130212, 3, ENSP000002724624MINT-67694 I2D: score=5 STRING: ENSP00000272462
    HCFC1P516101, 3, ENSP000003095554EBI-625002,EBI-396176 I2D: score=4 STRING: ENSP00000309555
    JUNP054121, 3EBI-625002,EBI-852823 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IDA--
    GO:0002230positive regulation of defense response to virus by host IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006935chemotaxis IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for CREB3

    1 HMDB Compound for CREB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10 Novoseek inferred chemical compound relationships for CREB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 82.8 55 1465398 (2), 9271389 (2), 9261149 (1), 10425189 (1) (see all 51)
    sterol 41.1 3 15798184 (1), 7903453 (1), 15550381 (1)
    cyclic amp 39.9 5 9658067 (1), 15548422 (1), 9271389 (1), 10907849 (1) (see all 5)
    tunicamycin 32.7 1 15845366 (1)
    tetrapeptide 31.8 2 12235138 (1), 10629049 (1)
    abscisic acid 26.9 2 11884679 (1), 12376636 (1)
    asparagine 18.2 1 8108415 (1)
    proline 16.7 3 12225289 (1), 12609830 (1), 8108415 (1)
    lipid 0 2 15798184 (1), 15550381 (1)
    zinc 0 1 7866428 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CREB3 gene: 
    NM_006368.4  

    Unigene Cluster for CREB3:

    CAMP responsive element binding protein 3
    Hs.522110  [show with all ESTs]
    Unigene Representative Sequence: NM_006368
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353704(uc003zxv.3 uc010mla.3) ENST00000486056
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    Additional mRNA sequence: 

    AF009368.1 AF029674.1 AF211848.1 AK299781.1 AK313635.1 BC009402.2 BC010158.2 FJ263669.1 

    13 DOTS entries:

    DT.92451593  DT.97862712  DT.92451583  DT.100825737  DT.100825752  DT.95248340  DT.100825735  DT.100825743 
    DT.100825745  DT.306486  DT.75159658  DT.95311278  DT.100825733 

    Selected AceView cDNA sequences (see all 297):

    BC009402 BU686622 AW449174 BQ668863 BM836671 BQ011960 AI611828 CR624840 
    AI953721 BM973759 BM699921 BU727437 CR593747 CR605383 R14706 CR610001 
    CF128132 AA760993 BM047356 BQ636622 CA487902 CR590714 AA235005 BM671129 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CREB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAGGCTC
    CREB3 Expression
    About this image


    CREB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Placenta (Extraembryonic Tissues)
    CREB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522110

    UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889
    Tissue specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level).
    Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREB3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb31 , 5 cAMP responsive element binding protein 31, 5 76.26(n)1
    68.77(a)1
      4 (23.05 cM)5
    129131  NM_013497.31  NP_038525.21 
     435623325 
    chicken
    (Gallus gallus)
    Aves CREB31 cAMP responsive element binding protein 3 60.64(n)
    55.72(a)
      427417  XM_424990.4  XP_424990.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB36
    cAMP responsive element binding protein 3
    66(a)
    1 ↔ 1
    GL343746.1(117288-125888)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163472 Xenopus laevis transcribed sequence with weak similarity more 73.81(n)    CD363181.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj05f072 Danio rerio cDNA clone MGC66452 IMAGE2600368, complete more 73.22(n)    BC055664.1 
    worm
    (Caenorhabditis elegans)
    Secernentea let-6076
    Protein LET-607 (let-607) mRNA, complete cds
    14(a)
    1 → many
    I(6574004-6585175) WBGene00002783


    ENSEMBL Gene Tree for CREB3 (if available)
    TreeFam Gene Tree for CREB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREB3 gene
    CREB3L22  CREB3L42  CREB3L12  CREB3L32  

    Find genes that share paralogs with CREB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREB3 (see all 56)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395236251,2
    --35734451(+) CTTTTC/TTTTTT 1 -- int10--------
    rs1179052441,2
    C,F--35734738(+) GGCATG/ATGCCA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1496594001,2
    --35734780(+) AGACAA/GGGTCT 1 -- int10--------
    rs21810281,2
    C,A,H--35734903(+) ACCAGT/GTTTTT 1 -- int1 trp34Minor allele frequency- G:0.23NA EA 244
    rs108142741,2
    C,F,A,H--35734956(+) TGGTCC/TGTGGA 1 -- int120Minor allele frequency- T:0.36NS EA NA CSA WA 2346
    rs1471681861,2
    C--35735133(+) GTGTGC/TGGAGG 2 R W mis11Minor allele frequency- T:0.00NA 4540
    rs1404935821,2
    C,F--35735134(+) TGTGCG/AGAGGA 2 /Q /R mis11Minor allele frequency- A:0.00NA 4540
    rs2004155981,2
    C--35735139(+) GGAGGA/GAGATT 2 K E mis10--------
    rs1412888121,2
    C--35735145(+) AGATTC/TGAAAT 2 R * stg11Minor allele frequency- T:0.00NA 4544
    rs1918300561,2
    C,F--35735173(+) GAGCCG/ACAGGA 2 /H /R mis11Minor allele frequency- A:0.00EU 1299

    HapMap Linkage Disequilibrium report for CREB3 (35732317 - 35737005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CREB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv25437CNV Loss19812545
    dgv8168n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): CREB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB3
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606443    OMIM disorders: --

    2 diseases for CREB3:    
    About MalaCards
    human t-cell leukemia virus type 1    herpes simplex


    Find genes that share disorders with CREB3           About GenesLikeMe

    3 Novoseek inferred disease relationships for CREB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 64.1 4 10425189 (1), 15044019 (1), 10907849 (1), 15755797 (1)
    herpes simplex 42.5 2 9271389 (1), 10871379 (1)
    tumors 0 1 19779205 (1)

    Genetic Association Database (GAD): CREB3
    Human Genome Epidemiology (HuGE) Navigator: CREB3 (1 document)

    Export disorders for CREB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREB3 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with CREB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PubMed id 9271389)1, 2, 3, 9 Lu R.... Misra V. (Mol. Cell. Biol. 1997)
    2. Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. (PubMed id 17296613)1, 2, 9 Jang S.W.... Ko J. (J. Biol. Chem. 2007)
    3. Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PubMed id 16940180)1, 2, 9 Liang G.... Lu R. (Mol. Cell. Biol. 2006)
    4. A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. (PubMed id 19779205)1, 2, 9 Kang H.... Ko J. (Mol. Endocrinol. 2009)
    5. Luman is capable of binding and activating transcription from the unfolded protein response element. (PubMed id 15845366)1, 2, 9 DenBoer L.M....Lu R. (Biochem. Biophys. Res. Commun. 2005)
    6. Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PubMed id 15001559)1, 2, 9 Ko J.... Na D.S. (FASEB J. 2004)
    7. Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)1, 2, 9 Misra V.... Korchinski P. (J. Biol. Chem. 2005)
    8. Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 2, 9 Mahajan S.S. and Wilson A.C. (Mol. Cell. Biol. 2000)
    9. N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. (PubMed id 10984507)1, 2, 9 Luciano R.L. and Wilson A.C. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    10. Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. (PubMed id 9389645)1, 2, 9 Freiman R.N. and Herr W. (Genes Dev. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10488 HGNC: 2347 AceView: CREB3 Ensembl:ENSG00000107175 euGenes: HUgn10488
    ECgene: CREB3 Kegg: 10488 H-InvDB: CREB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CREB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREB3 gene:
    Search GeneIP for patents involving CREB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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