CREB3 Gene
protein-coding GIFtS: 53
GCID: GC09P035722
|
|
cAMP responsive element binding protein 3(Previous name: cAMP responsive element binding protein 3 (luman) )
| |
Aliases
for CREB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CAMP Responsive Element Binding Protein 31 2 | | CAMP-Responsive Element-Binding Protein 32 3 | | LZIP1 2 3 5 | | CAMP Responsive Element Binding Protein 3 (Luman)1 | | Luman1 3 | | LUMAN2 | | Leucin Zipper Proitein2 3 | | Basic Leucine Zipper Protein2 | | Transcription Factor LZIP-Alpha2 3 | | Cyclic AMP Response Element (CRE)-Binding Protein/Activating TranscriptionFactor 12 | | CREB-32 3 | | Cyclic AMP-Responsive Element-Binding Protein 32 |
Export aliases for CREB3 gene to outside databasesPrevious GC identifers: GC09P036044 GC09P035901 |
Summaries
for CREB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CREB3:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. Thisprotein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cellfactor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSVimmediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that theinteraction between this protein and host cell factor C1 plays a role in the establishment of latency during HSVinfection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulumstress-associated protein degradation. Additional transcript variants have been identified, but their biologicalvalidity has not been determined.(provided by RefSeq, Nov 2009)
UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response(UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also arole in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1(HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR).Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration.Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein.Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring hostcell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicativecascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-inducedtranscriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases(HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote thechemotactic activity of leukocyte cellsFunction: Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activatesunfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survivalagainst ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containingreporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes requiredfor reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interactingwith HIV-1 Tat. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viraltransactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus:5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded proteinrespons element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II(5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1 promoter
Gene Wiki entry for CREB3
|
Genomic Views
for CREB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CREB3 gene promoter:
C/EBPbeta AP-1 Pax-6 ATF-2 STAT5A c-Ets-1 C/EBPalpha HEN1 ZID c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CREB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3CREB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P035722: view genomic region
(about GC identifiers)
Start:
|
35,732,317 bp from pter |
End:
|
35,737,005 bp from pter |
Size:
|
4,689 bases |
Orientation:
|
plus strand |
|
Proteins
for CREB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889 (See
protein sequence)Recommended Name: Cyclic AMP-responsive element-binding protein 3 Size: 395 amino acids; 43917 Da
Subunit: Homodimer; homodimerization is prevented by the HCV core protein. Interacts with HCFC1; the interaction isrequired to stimulate CREB3 transcriptional activity. Isoform 2 interacts with CREBZF; the interaction occurs only incombination with HCFC1. Isoform 2 interacts (via central part and transmembrane region) with TM7SF4 (via C-terminuscytoplasmic domain). Isoform 2 interacts with OS9. Isoform 2 interacts (via leucine-zipper domain) with CREBRF (vialeucine-zipper domain); the interaction occurs only after CREB3 activation and promotes CREB3 degradation. Isoform 2interacts (via C-terminal domain) with CCR1. Isoform 2 interacts (via leucine-zipper and transmembrane domains) withHIV-1 ENV (via cytoplasmic domain). Isoform 2 interacts (via leucine-zipper and transmembrane domains) with HIV-1TMgp41 (via cytoplasmic domain); the interaction reduces CREB3 stability. Interacts with the HCV core protein.Processed cyclic AMP-responsive element-binding protein 3 interacts with HIV-1 Tat
Subcellular location: Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane.Note=Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestredinto the cytoplasm by the HCV core protein
Subcellular location: Isoform 3: Nucleus. Cytoplasm. Note=Predominantly in the nucleus
Subcellular location: Processed cyclic AMP-responsive element-binding protein 3: Nucleus. Note=Upon RIP activation thetranscriptional active processed cyclic AMP-responsive element-binding protein 3 form translocates into the nucleus.Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci.Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB)
Caution: All experiments concerning the proteolytic cleavage are done with isoform 2
Secondary accessions: D0PTW6 O14671 O14919 Q5TCV1 Q96GK8 Q9H2W3 Q9UE77Alternative splicing: 3 isoforms: O43889-1 O43889-2 O43889-3 (Does not contain a helical transmembrane domain)Explore the universe of human proteins at neXtProt for CREB3: NX_O43889
Post-translational modifications:
The ER membrane embedded cyclic AMP-responsive element-binding protein 3 form is first proteolytically cleaved bysite-1 protease (S1P) that generates membrane-associated N-terminus and a luminal C-terminus forms. Themembrane-associated N-terminus form is further proteolytically processed probably by the site-2 protease (S2P) througha regulated intramembrane proteolysis (RIP), releasing the transcriptional active processed cyclic AMP-responsiveelement-binding protein 3 form, which is transported to the nucleus. The proteolytic cleavage is strongly inducedduring dendritic cell (DC) maturation and inhibited by TM7SF41
The processed cyclic AMP-responsive element-binding protein 3 is rapidly degraded1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43889
CREB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006359.3
ENSEMBL proteins: ENSP00000342136
Human Recombinant Protein Products:
Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table
CREB3 for ontologies About GeneDecksing
CREB3 Antibody Products:
Assay Products for CREB3: |
Protein
Domains /
Families
for CREB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CREB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43889ProtoNet protein and cluster: O43889 1 Blocks protein family: IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889Similarity: Belongs to the bZIP family. ATF subfamilySimilarity: Contains 1 bZIP (basic-leucine zipper) domain |
Function
for CREB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889Function: Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response(UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also arole in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1(HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR).Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration.Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein.Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring hostcell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicativecascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-inducedtranscriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases(HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote thechemotactic activity of leukocyte cellsFunction: Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activatesunfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Promotes cell survivalagainst ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containingreporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes requiredfor reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interactingwith HIV-1 Tat. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viraltransactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element (CRE) (consensus:5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded proteinrespons element (UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II(5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1 promoterInduction: Up-regulated upon differentiation of monocytes towards immature dendritic cells (DC). Down-regulated upon DCmaturation. Up-regulated by endoplasmic reticulum stress triggered by thapsigargin (Tg) or tunicamycin (Tm).Up-regulated by CCR1-dependent chemokines in an immediate early response and biphasic manner and by NF-kappa-B
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREB3
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
CREB3 for ontologies About GeneDecksing
|
Pathways & Interactions
for CREB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of cAMP-Dependent PKA | | | 2 | CREB Pathway | | | 3 | GPCR Pathway | | | 4 | Rho Family GTPases | | | 5 | G-Beta Gamma Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/45 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CREB3 (see all 45)
2  BioSystems Pathways for CREB3
5 
Kegg Pathways (Kegg details for CREB3):
CREB3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CREB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/142 Interacting proteins for CREB3 (O438891, 2, 3 ENSP000003421364) via UniProtKB, MINT, STRING, and/or I2D (see all 142)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| STX8 | Q9UNK02, 3, ENSP000003052554 | MINT-66240 I2D:
score=6 STRING: ENSP00000305255 | | APPBP2 | Q926242, 3, ENSP000000831824 | MINT-66791 I2D:
score=5 STRING: ENSP00000083182 | | MALL | Q130212, 3, ENSP000002724624 | MINT-67694 I2D:
score=5 STRING: ENSP00000272462 | | HCFC1 | P516101, 3, ENSP000003095554 | EBI-625002,EBI-2832627 I2D:
score=4 STRING: ENSP00000309555 | | JUN | P054121, 3 | EBI-625002,EBI-852823 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001558 | regulation of cell growth |
IDA | -- | | GO:0002230 | positive regulation of defense response to virus by host |
IDA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006935 | chemotaxis |
IEA | -- | | GO:0006986 | response to unfolded protein |
IEA | -- |
CREB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CREB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CREB3 for compounds About GeneDecksing
 Browse Tocris compounds for CREB3
1 HMDB Compound for CREB3 About this table
10 Novoseek chemical compound relationships for CREB3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
82.8 |
55 |
1465398 (2), 9271389 (2), 9261149 (1), 10425189 (1) (see all 51) |
| sterol |
41.1 |
3 |
15798184 (1), 7903453 (1), 15550381 (1) |
| cyclic amp |
39.9 |
5 |
9658067 (1), 15548422 (1), 9271389 (1), 10907849 (1) (see all 5) |
| tunicamycin |
32.7 |
1 |
15845366 (1) |
| tetrapeptide |
31.8 |
2 |
12235138 (1), 10629049 (1) |
| abscisic acid |
26.9 |
2 |
11884679 (1), 12376636 (1) |
| asparagine |
18.2 |
1 |
8108415 (1) |
| proline |
16.7 |
3 |
12225289 (1), 12609830 (1), 8108415 (1) |
| lipid |
0 |
2 |
15798184 (1), 15550381 (1) |
| zinc |
0 |
1 |
7866428 (1) |
Search CenterWatch for drugs/clinical trials and news about CREB3
|
Transcripts
for CREB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CREB3 gene: NM_006368.4 Unigene Cluster for CREB3: CAMP responsive element binding protein 3 Hs.522110 [show with all ESTs]Unigene Representative Sequence: NM_0063682 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000353704(uc003zxv.3 uc010mla.3) ENST00000486056
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CREB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CREB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CREB3 (NM_006368) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CREB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB3 |
Additional cDNA sequence: AF009368.1 AF029674.1 AF211848.1 AK299781.1 AK313635.1 BC009402.2 BC010158.2 FJ263669.1 13 DOTS entries: DT.92451593 DT.97862712 DT.92451583 DT.100825737 DT.100825752 DT.95248340 DT.100825735 DT.100825743 DT.100825745 DT.306486 DT.75159658 DT.95311278 DT.100825733 24/297 AceView cDNA sequences (see all 297): BE889329 BQ011960 AW449174 BU727437 CF127995 CB242139 AL552632 CR605383 BQ687322 CR623420 CR597898 BQ636622 CB306512 CD518157 CR610001 AL548963 AL575863 BM799707 BM561304 CR624840 BE504921 BM047356 CA487902 AI597679
GeneLoc Exon Structure
|
Expression
for CREB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CREB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAGGCTC
About this image
See CREB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CREB3
SOURCE GeneReport for Unigene cluster: Hs.522110
UniProtKB/Swiss-Prot: CREB3_HUMAN, O43889Tissue specificity: Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including CREB3:
Primer
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB3 |
Orthologs
for CREB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CREB3 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CREB31 |
cAMP responsive element binding protein 3 |
60.52(n)
55.72(a) |
|
427417 XM_424990.3 XP_424990.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CREB36 |
-- |
66(a) |
1 ↔ 1 |
GL343746.1(118078-122757) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.163472 |
Xenopus laevis transcribed sequence with weak similarity more |
73.81(n) |
|
CD363181.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj05f072 |
Danio rerio cDNA clone MGC66452 IMAGE2600368, complete more |
73.22(n) |
|
BC055664.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
15(a) |
1 → many |
Group14.4(543638-551371) |
worm
(Caenorhabditis elegans) |
Secernentea |
crh-26let-6076 |
LEThal family member (let-607) |
17(a)11(a) |
possible ortholog1 ↔ many |
II(5179028-5187561) I(6574003-6585176) |
ENSEMBL Gene Tree for CREB3 (if available)
TreeFam Gene Tree for CREB3 (if available) |
Paralogs
for CREB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CREB3 gene
- CREB3L22 CREB3L42 CREB3L12 CREB3L32
CREB3 for paralogs About GeneDecksing
|
Genomic Variants
for CREB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CREB3 (35732317 - 35737005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CREB3
1 CNV: 65382 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CREB3 |
|
Disorders
/ Diseases
for CREB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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CREB3 for disorders About GeneDecksing
OMIM gene information: 606443
OMIM disorders: --
20/21  diseases for CREB3 (see all 21): About MalaCardsherpes simplex human t-cell leukemia virus type 1 kaposi's sarcoma chondrodysplasia
t-cell leukemia microphthalmia acne hepatitis c
huntington's disease hepatitis b sarcoma leukemia
hepatitis prostate cancer breast cancer ischemia
glioblastoma hypoxia prostatitis immunodeficiency
3 Novoseek disease relationships for CREB3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: CREB3 (1 document)
Export disorders for CREB3 gene to outside databases
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Publications
for CREB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for CREB3 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with CREB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. (PubMed id 9271389)1, 2, 3, 9 Lu R.... Misra V. (1997)
- Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. (PubMed id 17296613)1, 2, 9 Jang S.W....Ko J. (2007)
- Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. (PubMed id 16940180)1, 2, 9 Liang G....Lu R. (2006)
- A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor. (PubMed id 19779205)1, 2, 9 Kang H.... Ko J. (2009)
- Luman is capable of binding and activating transcription from the unfolded protein response element. (PubMed id 15845366)1, 2, 9 DenBoer L.M....Lu R. (2005)
- Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. (PubMed id 15001559)1, 2, 9 Ko J.... Na D.S. (2004)
- Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman. (PubMed id 15705566)1, 2, 9 Misra V.... Korchinski P. (2005)
- Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. (PubMed id 10629049)1, 2, 9 Mahajan S.S. and Wilson A.C. (2000)
- N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. (PubMed id 10984507)1, 2, 9 Luciano R.L. and Wilson A.C. (2000)
- Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. (PubMed id 9389645)1, 2, 9 Freiman R.N. and Herr W. (1997)
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External Searches for CREB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CREB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing CREB3 gene
(According to HUGE)
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| -- |
Specialized Databases showing CREB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for CREB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CREB3 gene:
Search GeneIP for patents involving CREB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CREB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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