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CREB1 Gene

protein-coding   GIFtS: 71
GCID: GC02P208394

CAMP Responsive Element Binding Protein 1

  See CREB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAMP Responsive Element Binding Protein 11 2     Active Transcription Factor CREB2
CREB-12 3     CAMP-Response Element-Binding Protein-12
CAMP-Responsive Element-Binding Protein 12 3     Cyclic AMP-Responsive Element-Binding Protein 12
CREB2     Transactivator Protein2

External Ids:    HGNC: 23451   Entrez Gene: 13852   Ensembl: ENSG000001182607   OMIM: 1238105   UniProtKB: P162203   

Export aliases for CREB1 gene to outside databases

Previous GC identifers: GC02P206611 GC02P207119 GC02P208358 GC02P208597 GC02P208220 GC02P208102 GC02P200237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CREB1 Gene:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins.
This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is
phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation
of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREB1 Gene:
CREB1 (cAMP responsive element binding protein 1) is a protein-coding gene. Diseases associated with CREB1 include diabetic encephalopathy, and histiocytoma, angiomatoid fibrous, somatic. GO annotations related to this gene include transcription cofactor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA
cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is
enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different
cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose
cells

Gene Wiki entry for CREB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CREB1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB1 promoter sequence
   Search Chromatin IP Primers for CREB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q34

CREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P208394:  view genomic region     (about GC identifiers)

Start:
208,394,461 bp from pter      End:
208,470,284 bp from pter
Size:
75,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 1  
Size: 341 amino acids; 36688 Da
Subunit: Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts,
through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on
Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and
transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds
to HIPK2. Interacts with SGK1
1 PDB 3D structure from and Proteopedia for CREB1:
2LXT (3D)    
Secondary accessions: P21934 Q6V963 Q9UMA7
Alternative splicing: 3 isoforms:  P16220-1   P16220-2   P16220-3   (Highly expressed in adult testis and sperm)

Explore the universe of human proteins at neXtProt for CREB1: NX_P16220

Explore proteomics data for CREB1 at MOPED

Post-translational modifications: 

  • Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of
    CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By
    similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional
    activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more
    potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks
    CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity).
    Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the
    recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to
    mitogenic or stress stimuli1
  • Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this
    protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization1
  • Ubiquitination2 at Lys136, Lys330
  • Modification sites at PhosphoSitePlus

  • See CREB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004370.1  NP_604391.1  

    ENSEMBL proteins: 
     ENSP00000405539   ENSP00000387699   ENSP00000236995   ENSP00000407227   ENSP00000403678  
     ENSP00000392428   ENSP00000404890   ENSP00000405711   ENSP00000391125   ENSP00000412016  
     ENSP00000401803   ENSP00000363518   ENSP00000445892   ENSP00000440809  
    Reactome Protein details: P16220

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    Sino Biological Recombinant Protein for CREB1
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    CREB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CREB1
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    CREB1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CREB1
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    Cell Signaling Technology (CST) Sandwich ELISA Kits for CREB1 (CREB)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CREB1: (see all 3
                        phospho-CREB (Ser133) InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR003102 Coactivator_CBP_pKID
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry P16220

    ProtoNet protein and cluster: P16220

    3 Blocks protein domains:
    IPB001630 cAMP response element binding (CREB) protein signature
    IPB003102 Coactivator CBP
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 KID (kinase-inducible) domain


    Find genes that share domains with CREB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREB1_HUMAN, P16220
    Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA
    cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is
    enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different
    cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose
    cells

         Genatlas biochemistry entry for CREB1:
    cAMP response element binding protein 1 (transcription regulator)

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA19861239
    GO:0001102RNA polymerase II activating transcription factor binding IPI19861239
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA19861239
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA8798441
         
    Find genes that share ontologies with CREB1           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Creb1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with CREB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CREB1: Creb1tm3.1Gsc Creb1tm1Gsc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CREB1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREB1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for CREB1 (see all 1633):
    A2M,  A4GALT,  AADACL4,  AANAT,  ABCA1,  ABCC8,  ABCG1,  ABHD12,  ABHD4,  ABHD5

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CGGTGACGTCAC 

    miRNA
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    miRTarBase miRNAs that target CREB1:
    hsa-mir-103a-3p (MIRT004766), hsa-mir-203a (MIRT006496), hsa-mir-34b-5p (MIRT000066), hsa-mir-122-5p (MIRT023389), hsa-mir-182-5p (MIRT006273), hsa-mir-200b-3p (MIRT007342)

    Block miRNA regulation of human, mouse, rat CREB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CREB1 (see all 215):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-100* hsa-miR-106a hsa-miR-134 hsa-miR-128 hsa-miR-605 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidCREB1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CREB1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CREB1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CREB1_HUMAN, P16220: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    plasma membrane2
    cytosol1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005719nuclear euchromatin IDA19861239

    Find genes that share ontologies with CREB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CREB1 About   (see all 129)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    G-protein mediated events0.65
    EGFR interacts with phospholipase C-gamma0.94
    Phospholipase C-mediated cascade0.59
    PLC-gamma1 signalling0.94
    Opioid Signalling0.54
    CaM pathway0.93
    Beta 2 adrenergic dependent CFTR expression0.50
    2Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    3Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    4ATM Pathway
    ATM Pathway
    ATM Signaling Pathway0.00
    5PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66


    Find genes that share SuperPaths with CREB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CREB1
        VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CREB1 (see all 50)
        FLT3 Signaling
    Nuclear Receptor Activation by Vitamin-A
    Toll-Like Receptors Pathway
    Interferon Pathway
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for CREB1
        Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for CREB1 (see all 24)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Development GDNF family signaling

    Selected BioSystems Pathways for CREB1 (see all 45)
        Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    DNA damage response
    EGFR1 Signaling Pathway
    Adipogenesis

    1 Sino Biological Pathway for CREB1
        Death Receptor Signaling

    Selected Reactome Pathways for CREB1 (see all 14)
        CREB phosphorylation
    AKT phosphorylates targets in the nucleus
    Circadian Clock
    CREB phosphorylation through the activation of CaMKII
    CREB phosphorylation through the activation of Adenylate Cyclase


    Selected Kegg Pathways  (Kegg details for CREB1) (see all 23):
        PI3K-Akt signaling pathway
    Adrenergic signaling in cardiomyocytes
    Osteoclast differentiation
    Antigen processing and presentation
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CREB1 (see all 12): 
              Neurogenesis in human mouse rat
              Prostate Cancer in human mouse rat
              Adipogenesis in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CREB1 (P162201, 2, 3 ENSP000003876994) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684313, ENSP000002446614I2D: score=1 STRING: ENSP00000244661
    HIST1H3AP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter IDA19861239

    Find genes that share ontologies with CREB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for CREB1

    3 HMDB Compounds for CREB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for CREB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetactivator17300755 17324065 16879221 17122581 17083486
    NaloxoneEN 1530 Base (see all 7)465-65-6targetother/unknown12969258 15953421 16417577 14653953 12956944

    Selected Novoseek inferred chemical compound relationships for CREB1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 89.2 495 11599000 (5), 7619208 (4), 10319317 (4), 16125054 (3) (see all 99)
    forskolin 76.8 125 18372325 (6), 11557237 (5), 10406459 (4), 16125054 (3) (see all 72)
    pd 98,059 65.9 36 9657746 (1), 11481274 (1), 14651954 (1), 17680988 (1) (see all 30)
    sb 203580 59.7 25 14651954 (1), 17490625 (1), 12631076 (1), 12763014 (1) (see all 18)
    na-mda 59.6 6 16678346 (3), 14667449 (3)
    leucine 55.8 61 8479741 (4), 17565599 (3), 8467239 (3), 15663480 (2) (see all 33)
    calcium 53.5 242 12716953 (5), 12773552 (5), 16151051 (5), 15073039 (5) (see all 99)
    nmda 50.8 86 12421605 (6), 10804193 (6), 9068120 (4), 10414964 (2) (see all 40)
    kt 5720 49.2 2 15731115 (1), 12453898 (1)
    ly294002 48.2 12 19224810 (2), 11902114 (1), 17579344 (1), 18615584 (1) (see all 8)

    2 PharmGKB related drug/compound annotations for CREB1 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  



    Find genes that share compounds with CREB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CREB1 gene (2 alternative transcripts): 
    NM_004379.3  NM_134442.3  

    Unigene Cluster for CREB1:

    CAMP responsive element binding protein 1
    Hs.516646  [show with all ESTs]
    Unigene Representative Sequence: NM_134442
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000430624 ENST00000432329(uc002vcc.3 uc002vcd.3) ENST00000353267
    ENST00000445803 ENST00000421139 ENST00000494094 ENST00000452474 ENST00000414681
    ENST00000480189 ENST00000464407 ENST00000448277 ENST00000457101 ENST00000418081
    ENST00000455757 ENST00000494983 ENST00000446449 ENST00000451164 ENST00000374397

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    Selected qRT-PCR Assays for microRNAs that regulate CREB1 (see all 215):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-100* hsa-miR-106a hsa-miR-134 hsa-miR-128 hsa-miR-605 hsa-miR-3653
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12154 VA4-11729 VA6-11289) for CREB1 

    Additional mRNA sequence: 

    AK091534.1 AK095116.1 AK123952.1 AK126342.1 AK298740.1 AK302333.1 AK312747.1 AK315226.1 
    AY347527.1 BC010636.1 BC095407.1 BT019509.1 CR407617.1 M27691.1 M34356.1 X55545.1 
    X60003.1 

    16 DOTS entries:

    DT.114141  DT.100815280  DT.100815281  DT.40116826  DT.70103345  DT.100815283  DT.40209843  DT.100815282 
    DT.91815594  DT.121638558  DT.95131151  DT.100815284  DT.91747721  DT.95340157  DT.95357936  DT.91646223 

    Selected AceView cDNA sequences (see all 287):

    R85654 BQ050080 CB216816 BM680964 AA495862 AA001703 BM470007 CD721997 
    AA328323 AA829502 M27691 AI825402 AI005268 BQ001714 CA449108 CR621261 
    AA804489 BM720888 AW070705 BM457253 AA455568 BQ004452 BF198001 CR407617 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                -     -                             -     -                       -     -     -                                             
    SP2:                                -     -                 -           -     -                       -     -     -                                             
    SP3:                                                                    -     -                                                                                 
    SP4:                                -     -                             -     -           -     -     -     -     -     -                                       
    SP5:                                                        -           -     -                       -     -     -                                             


    ECgene alternative splicing isoforms for CREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CREB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAAATA
    CREB1 Expression
    About this image


    CREB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CREB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CREB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516646
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CREB1 (see all 12): 
              Neurogenesis in human mouse rat
              Prostate Cancer in human mouse rat
              Adipogenesis in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              TGFB Signaling Targets in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CREB1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb11 , 5 cAMP responsive element binding protein 11, 5 95.31(n)1
    99.71(a)1
      1 (32.74 cM)5
    129121  NM_009952.21  NP_034082.11 
     645328045 
    chicken
    (Gallus gallus)
    Aves CREB11 cAMP responsive element binding protein 1 85.73(n)
    98.78(a)
      395099  NM_204450.2  NP_989781.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB16
    cAMP responsive element binding protein 1
    82(a)
    1 ↔ 1
    GL343343.1(76381-90847)
    African clawed frog
    (Xenopus laevis)
    Amphibia creb1-prov2 cAMP responsive element binding protein 1 80.38(n)    BC041206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555982 similar to cAMP responsive element binding protein more 78.06(n)   393883  BC044436.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebB-17A6
    Cyclic-AMP response element binding protein B at 1...
    29(a)
    1 → many
    X(18260733-18271897)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-16
    Protein CRH-1, isoform g
    23(a)
    1 → many
    III(11657738-11693837) WBGene00000793


    ENSEMBL Gene Tree for CREB1 (if available)
    TreeFam Gene Tree for CREB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CREB1 gene
    ATF12  CREM2  
    3 SIMAP similar genes for CREB1 using alignment to 15 protein entries:     CREB1_HUMAN (see all proteins):
    ATF1    CREM    EWSR1/ATF1 fusion

    Find genes that share paralogs with CREB1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CREB1
    PGOHUM00000240204 PGOHUM00000240215 PGOHUM00000240798


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CREB1 (see all 1363)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901923481,2
    --207782344(+) AACTAA/TGAATG 2 -- us2k10--------
    rs1458177481,2
    --207782350(+) GAATGC/TAGGAT 2 -- us2k10--------
    rs761808701,2
    F--207782445(+) CCTAGG/CAAAGT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs563194331,2
    C,F--207782536(+) GTTGTT/CAAAGA 2 -- us2k13Minor allele frequency- C:0.10WA 122
    rs1826327091,2
    --207782668(+) GATCCA/GCTGCA 2 -- us2k10--------
    rs1477692201,2
    --207782711(+) CAGAGC/TCACTT 2 -- us2k10--------
    rs1412397391,2
    C--207782717(+) CACTTC/TAGGTG 2 -- us2k10--------
    rs1876360761,2
    --207782726(+) TGAGCC/GGTGGG 2 -- us2k10--------
    rs739834491,2
    C,F--207782882(+) GAGCCG/CGTAGA 2 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1469450051,2
    --207782906(+) AGAGTA/GACAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CREB1 (208394461 - 208470284 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CREB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3131CNV Loss18451855
    nsv821888CNV Gain20364138

    Human Gene Mutation Database (HGMD): CREB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123810   
    OMIM disorders: 612160  
    UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. A
    chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation
    t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this
    tumor type
  • Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of
    agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to
    surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (PubMed:22267179)

  • 18 diseases for CREB1:    
    About MalaCards
    diabetic encephalopathy    histiocytoma, angiomatoid fibrous, somatic    hidradenoma    melanoma of soft parts
    coffin-lowry syndrome    fetal alcohol spectrum disorder    cerebral hypoxia    human t-cell leukemia virus type 2
    cerebral atrophy    opiate dependence    rubinstein-taybi syndrome    fukuyama congenital muscular dystrophy
    hemimegalencephaly    histiocytoma    pontocerebellar hypoplasia    neurofibromatosis
    age related macular degeneration    neuroblastoma

    8 diseases from the University of Copenhagen DISEASES database for CREB1:
    Alzheimer's disease     Rubinstein-Taybi syndrome     Vascular disease     Clear cell sarcoma
    Leukemia     Fibrous histiocytoma     Huntington's disease     Toxic encephalopathy

    Find genes that share disorders with CREB1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CREB1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 78 18 8610463 (1), 17644518 (1), 18599479 (1), 17579344 (1) (see all 17)
    leukemogenesis 39.4 11 17975014 (2), 19960054 (1), 11895805 (1), 15837624 (1) (see all 5)
    sarcoma clear cell 37.4 3 17000668 (1), 19561568 (1), 12831531 (1)
    drug addiction 35.3 5 11200184 (1), 12559841 (1), 11397804 (1), 15982754 (1) (see all 5)
    nonfunctioning pituitary tumor 33 1 7476961 (1)
    neurodegeneration 32.8 7 18830614 (1), 14766349 (1), 16525063 (1), 16337876 (1) (see all 6)
    adrenocortical cancer 30.9 4 10634409 (2), 12530696 (1), 12915693 (1)
    neurodegenerative diseases 30.2 6 17722060 (1), 14766349 (1), 16207717 (1), 18036576 (1)
    metastatic melanoma 29.4 12 11642609 (2), 9733794 (1), 15523674 (1), 16306050 (1) (see all 10)
    memory disorders 28.9 2 16266283 (1), 12556206 (1)

    Genetic Association Database (GAD): CREB1
    Human Genome Epidemiology (HuGE) Navigator: CREB1 (33 documents)

    Export disorders for CREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CREB1 gene, integrated from 10 sources (see all 1865):
    (articles sorted by number of sources associating them with CREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. (PubMed id 17300755)1, 4, 7, 9 Perlis R.H....Smoller J.W. (Biol. Psychiatry 2007)
    2. Association study of CREB1 with Major Depressive Disorder and related phenotypes. (PubMed id 19194961)1, 4, 9 Hettema J.M....Chen X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    3. Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. (PubMed id 15733869)1, 2, 9 David S. and Kalb R.G. (FEBS Lett. 2005)
    4. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2, 9 Screaton R.A.... Montminy M. (Cell 2004)
    5. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 9 Iourgenko V.... Labow M.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Transcriptional activation of egr-1 by granulocyte-macrophage colony- stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. (PubMed id 7608156)1, 2, 9 Lee H.-J.J.... Sakamoto K.M. (J. Biol. Chem. 1995)
    7. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PubMed id 19844206)1, 4, 9 Dong C....Licinio J. (Mol. Psychiatry 2009)
    8. Lithium response and genetic variation in the CREB family of genes. (PubMed id 18189280)1, 4, 9 Mamdani F....Turecki G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    9. Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. (PubMed id 18678793)1, 4, 9 Perlis R.H....Breiter H.C. (Arch. Gen. Psychiatry 2008)
    10. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. (PubMed id 17460549)1, 4, 9 Wilkie M.J....Smith G. (Pharmacogenet. Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1385 HGNC: 2345 AceView: CREB1 Ensembl:ENSG00000118260 euGenes: HUgn1385
    ECgene: CREB1 Kegg: 1385 H-InvDB: CREB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CREB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CREB1 gene:
    Search GeneIP for patents involving CREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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