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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CREB1 Gene

protein-coding   GIFtS: 70
GCID: GC02P208394

CAMP Responsive Element Binding Protein 1

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CAMP Responsive Element Binding Protein 11 2     Active Transcription Factor CREB2
CREB-12 3     CAMP-Response Element-Binding Protein-12
CAMP-Responsive Element-Binding Protein 12 3     Cyclic AMP-Responsive Element-Binding Protein 12
CREB2     Transactivator Protein2

External Ids:    HGNC: 23451   Entrez Gene: 13852   Ensembl: ENSG000001182607   OMIM: 1238105   UniProtKB: P162203   

Export aliases for CREB1 gene to outside databases

Previous GC identifers: GC02P206611 GC02P207119 GC02P208358 GC02P208597 GC02P208220 GC02P208102 GC02P200237


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CREB1 Gene:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins.
This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is
phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation
of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CREB1 Gene: 
CREB1 (cAMP responsive element binding protein 1) is a protein-coding gene. Diseases associated with CREB1 include human t-cell leukemia virus type 1, and histiocytoma, angiomatoid fibrous, somatic, and among its related super-pathways are PKA activation in glucagon signalling and GDNF-Family Ligands and Receptor Interactions. GO annotations related to this gene include transcription cofactor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA
cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is
enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different
cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose
cells

Gene Wiki entry for CREB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREB1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCREB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CREB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CREB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q34

CREB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P208394:  view genomic region     (about GC identifiers)

Start:
208,394,461 bp from pter      End:
208,470,284 bp from pter
Size:
75,824 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 1  
Size: 341 amino acids; 36688 Da
Subunit: Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts,
through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on
Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and
transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds
to HIPK2. Interacts with SGK1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for CREB1:
2LXT (3D)    
Secondary accessions: P21934 Q6V963 Q9UMA7
Alternative splicing: 3 isoforms:  P16220-1   P16220-2   P16220-3   (Highly expressed in adult testis and sperm)

Explore the universe of human proteins at neXtProt for CREB1: NX_P16220

Explore proteomics data for CREB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of
    CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By
    similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional
    activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more
    potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks
    CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity).
    Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the
    recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to
    mitogenic or stress stimuli
  • UniProtKB: Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this
    protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16220

  • CREB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CREB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004370.1  NP_604391.1  

    ENSEMBL proteins: 
     ENSP00000405539   ENSP00000387699   ENSP00000236995   ENSP00000407227   ENSP00000403678  
     ENSP00000392428   ENSP00000404890   ENSP00000405711   ENSP00000391125   ENSP00000412016  
     ENSP00000401803   ENSP00000363518   ENSP00000445892   ENSP00000440809  
    Reactome Protein details: P16220
    Human Recombinant Protein Products for CREB1: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005719nuclear euchromatin IDA19861239

    CREB1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    3 InterPro protein domains:
     IPR004827 bZIP
     IPR003102 Coactivator_CBP_pKID
     IPR001630 Leuzip_CREB

    Graphical View of Domain Structure for InterPro Entry P16220

    ProtoNet protein and cluster: P16220

    3 Blocks protein domains:
    IPB001630 cAMP response element binding (CREB) protein signature
    IPB003102 Coactivator CBP
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
    Similarity: Belongs to the bZIP family
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain
    Similarity: Contains 1 KID (kinase-inducible) domain


    CREB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREB1_HUMAN, P16220
    Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA
    cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is
    enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different
    cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose
    cells

         Genatlas biochemistry entry for CREB1:
    cAMP response element binding protein 1 (transcription regulator)

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA19861239
    GO:0001102RNA polymerase II activating transcription factor binding IPI19861239
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA19861239
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA8798441
         
    CREB1 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Creb1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  muscle 
     nervous system  normal  reproductive system  respiratory system  skeleton 

    CREB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CREB1: Creb1tm3.1Gsc Creb1tm1Gsc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CREB1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CREB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CREB1 

    10/1653 SABiosciences Target genes for CREB1 (see all 1653):
    A2M A4GALT AADACL4 AANAT ABCA1 ABCC8 ABCG1 ABHD12 ABHD4 ABHD5

    miRNA
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    8/215 QIAGEN miScript miRNA Assays for microRNAs that regulate CREB1 (see all 215):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-100* hsa-miR-106a hsa-miR-134 hsa-miR-128 hsa-miR-605 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidCREB1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CREB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CREB1 About   (see all 133)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA-mediated phosphorylation of CREB0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Beta-2 adrenergic-dependent CFTR expression0.74
    Transcription CREM signaling in testis0.30
    2Development EGFR signaling pathway
    Development GDNF family signaling0.45
    BDNF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    3Development IGF-RI signaling
    Development IGF-RI signaling0.49
    Development IGF-1 receptor signaling0.48
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    5Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/25 EMD Millipore Pathways for CREB1 (see all 25)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Transcription factors in neurogenesis
    Development A1 receptor signaling
    Signal transduction IP3 signaling
    Development Role of Activin A in cell differentiation and proliferation

    2 R&D Systems Pathways for CREB1
        VEGF - VEGF R2 Signaling Pathways
    TGF-beta Signaling Pathways

    5/50 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CREB1 (see all 50)
        FLT3 Signaling
    Nuclear Receptor Activation by Vitamin-A
    Toll-Like Receptors Pathway
    Interferon Pathway
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for CREB1
        Neuroscience

    5/24 GeneGo (Thomson Reuters) Pathways for CREB1 (see all 24)
        Development A2A receptor signaling
    Signal transduction cAMP signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Development GDNF family signaling

    5/41 BioSystems Pathways for CREB1 (see all 41)
        DNA damage response
    Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    EGFR1 Signaling Pathway
    G1 to S cell cycle control

    1 Sino Biological Pathway for CREB1 
        Death Receptor Signaling

    5/84        Reactome Pathways for CREB1 (see all 84)
        CREB phosphorylation
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll Like Receptor 3 (TLR3) Cascade
    MyD88-independent cascade


    5/22         Kegg Pathways  (Kegg details for CREB1) (see all 22):
        PI3K-Akt signaling pathway
    Osteoclast differentiation
    Antigen processing and presentation
    TNF signaling pathway
    Circadian rhythm


    CREB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CREB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/169 Interacting proteins for CREB1 (P162201, 2, 3 ENSP000003876994) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3BP684313, ENSP000002446614I2D: score=1 STRING: ENSP00000244661
    HIST1H3AP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/47 biological process terms (GO ID links to tree view) (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006468protein phosphorylation IDA8798441

    CREB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CREB1 for compounds           About GeneDecksing

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    3 HMDB Compounds for CREB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for CREB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetactivator17300755 17324065 16879221 17122581 17083486
    NaloxoneEN 1530 Base (see all 7)465-65-6targetother/unknown12969258 15953421 16417577 14653953 12956944

    10/140 Novoseek inferred chemical compound relationships for CREB1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 89.2 495 11599000 (5), 7619208 (4), 10319317 (4), 16125054 (3) (see all 99)
    forskolin 76.8 125 18372325 (6), 11557237 (5), 10406459 (4), 16125054 (3) (see all 72)
    pd 98,059 65.9 36 9657746 (1), 11481274 (1), 14651954 (1), 17680988 (1) (see all 30)
    sb 203580 59.7 25 14651954 (1), 17490625 (1), 12631076 (1), 12763014 (1) (see all 18)
    na-mda 59.6 6 16678346 (3), 14667449 (3)
    leucine 55.8 61 8479741 (4), 17565599 (3), 8467239 (3), 15663480 (2) (see all 33)
    calcium 53.5 242 12716953 (5), 12773552 (5), 16151051 (5), 15073039 (5) (see all 99)
    nmda 50.8 86 12421605 (6), 10804193 (6), 9068120 (4), 10414964 (2) (see all 40)
    kt 5720 49.2 2 15731115 (1), 12453898 (1)
    ly294002 48.2 12 19224810 (2), 11902114 (1), 17579344 (1), 18615584 (1) (see all 8)

    2 PharmGKB related drug/compound annotations for CREB1 gene    About this table
    Drug/compound PharmGKB Annotation
    antidepressantsCA  
    citalopramCA  

    Search CenterWatch for drugs/clinical trials and news about CREB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CREB1 gene (2 alternative transcripts): 
    NM_004379.3  NM_134442.3  

    Unigene Cluster for CREB1:

    CAMP responsive element binding protein 1
    Hs.516646  [show with all ESTs]
    Unigene Representative Sequence: NM_134442
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000430624 ENST00000432329(uc002vcc.3 uc002vcd.3) ENST00000353267
    ENST00000445803 ENST00000421139 ENST00000494094 ENST00000452474 ENST00000414681
    ENST00000480189 ENST00000464407 ENST00000448277 ENST00000457101 ENST00000418081
    ENST00000455757 ENST00000494983 ENST00000446449 ENST00000451164 ENST00000374397

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK091534.1 AK095116.1 AK123952.1 AK126342.1 AK298740.1 AK302333.1 AK312747.1 AK315226.1 
    AY347527.1 BC010636.1 BC095407.1 BT019509.1 CR407617.1 M27691.1 M34356.1 X55545.1 
    X60003.1 

    16 DOTS entries:

    DT.114141  DT.100815280  DT.100815281  DT.40116826  DT.70103345  DT.100815283  DT.40209843  DT.100815282 
    DT.91815594  DT.121638558  DT.95131151  DT.100815284  DT.91747721  DT.95340157  DT.95357936  DT.91646223 

    24/287 AceView cDNA sequences (see all 287):

    M27691 AA603789 M34356 BF198001 AW134796 AA256087 BX646312 BF197612 
    AA455568 AA292857 BQ001714 AU107544 BQ431704 AA495862 CA419113 AA573108 
    CA449108 BQ221426 NM_134442 R85654 AA504144 AL556137 BM982774 CR621261 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                -     -                             -     -                       -     -     -                                             
    SP2:                                -     -                 -           -     -                       -     -     -                                             
    SP3:                                                                    -     -                                                                                 
    SP4:                                -     -                             -     -           -     -     -     -     -     -                                       
    SP5:                                                        -           -     -                       -     -     -                                             


    ECgene alternative splicing isoforms for CREB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CREB1 expression in normal human tissues (normalized intensities)      CREB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAAAATA
    CREB1 Expression
    About this image


    CREB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   

    See CREB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CREB1

    SOURCE GeneReport for Unigene cluster: Hs.516646
        SABiosciences Expression via Pathway-Focused PCR Arrays including CREB1 (see all 12): 
              Neurogenesis in human mouse rat
              Prostate Cancer in human mouse rat
              Adipogenesis in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              TGFB Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CREB1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Creb11 , 5 cAMP responsive element binding protein 11, 5 95.21(n)1
    99.69(a)1
      1 (32.74 cM)5
    129121  NM_133828.21  NP_598589.21 
     645328045 
    chicken
    (Gallus gallus)
    Aves CREB11 cAMP responsive element binding protein 1 85.73(n)
    98.78(a)
      395099  NM_204450.2  NP_989781.1 
    lizard
    (Anolis carolinensis)
    Reptilia CREB16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343343.1(76381-90847)
    African clawed frog
    (Xenopus laevis)
    Amphibia creb1-prov2 cAMP responsive element binding protein 1 80.38(n)    BC041206.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555982 similar to cAMP responsive element binding protein more 78.06(n)   393883  BC044436.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CrebB-17A6
    Cyclic-AMP response element binding protein B at 1...
    19(a)
    1 → many
    X(18260733-18271897)
    worm
    (Caenorhabditis elegans)
    Secernentea crh-16
    Protein CRH-1, isoform c
    16(a)
    1 → many
    III(11657738-11693837)


    ENSEMBL Gene Tree for CREB1 (if available)
    TreeFam Gene Tree for CREB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CREB1 gene
    ATF12  CREM2  
    3 SIMAP similar genes for CREB1 using alignment to 15 protein entries:     CREB1_HUMAN (see all proteins):
    ATF1    CREM    EWSR1/ATF1 fusion

    CREB1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CREB1
    PGOHUM00000240204 PGOHUM00000240215 PGOHUM00000240798


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1363 SNPs in CREB1 are shown (see all 1363)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0680774
    ----see VAR_0680772 D G mis40--------
    rs1901923481,2
    --207782344(+) AACTAA/TGAATG 2 -- us2k10--------
    rs1458177481,2
    --207782350(+) GAATGC/TAGGAT 2 -- us2k10--------
    rs761808701,2
    F--207782445(+) CCTAGG/CAAAGT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs563194331,2
    C,F--207782536(+) GTTGTT/CAAAGA 2 -- us2k13Minor allele frequency- C:0.10WA 122
    rs1826327091,2
    --207782668(+) GATCCA/GCTGCA 2 -- us2k10--------
    rs1477692201,2
    --207782711(+) CAGAGC/TCACTT 2 -- us2k10--------
    rs1412397391,2
    C--207782717(+) CACTTC/TAGGTG 2 -- us2k10--------
    rs1876360761,2
    --207782726(+) TGAGCC/GGTGGG 2 -- us2k10--------
    rs739834491,2
    C,F--207782882(+) GAGCCG/CGTAGA 2 -- us2k12Minor allele frequency- C:0.05WA 120

    HapMap Linkage Disequilibrium report for CREB1 (208394461 - 208470284 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CREB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3131CNV Loss18451855
    nsv821888CNV Gain20364138


    Human Gene Mutation Database (HGMD): CREB1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CREB1
    DNA2.0 Custom Variant and Variant Library Synthesis for CREB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123810   
    OMIM disorders: 612160  
    UniProtKB/Swiss-Prot: CREB1_HUMAN, P16220
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. A
    chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation
    t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this
    tumor type
  • Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of
    agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to
    surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (PubMed:22267179)

  • 20/136 diseases for CREB1 (see all 136):    About MalaCards
    human t-cell leukemia virus type 1    histiocytoma, angiomatoid fibrous, somatic    human t-cell leukemia virus type 2    fetal alcohol spectrum disorder
    coffin-lowry syndrome    cerebral hypoxia    opiate dependence    hidradenoma
    rubinstein-taybi syndrome    melanoma of soft part    hemimegalencephaly    fukuyama congenital muscular dystrophy
    alcohol abuse    neurofibromatosis    growth hormone secreting pituitary adenoma    cerebral atrophy
    clear cell sarcoma    dentatorubral-pallidoluysian atrophy    congenital muscular dystrophy    histiocytoma

    8 diseases from the University of Copenhagen DISEASES database for CREB1:
    Alzheimer's disease     Rubinstein-Taybi syndrome     Vascular disease     Clear cell sarcoma
    Leukemia     Fibrous histiocytoma     Huntington's disease     Toxic encephalopathy

    CREB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for CREB1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 78 18 8610463 (1), 17644518 (1), 18599479 (1), 17579344 (1) (see all 17)
    leukemogenesis 39.4 11 17975014 (2), 19960054 (1), 11895805 (1), 15837624 (1) (see all 5)
    sarcoma clear cell 37.4 3 17000668 (1), 19561568 (1), 12831531 (1)
    drug addiction 35.3 5 11200184 (1), 12559841 (1), 11397804 (1), 15982754 (1) (see all 5)
    nonfunctioning pituitary tumor 33 1 7476961 (1)
    neurodegeneration 32.8 7 18830614 (1), 14766349 (1), 16525063 (1), 16337876 (1) (see all 6)
    adrenocortical cancer 30.9 4 10634409 (2), 12530696 (1), 12915693 (1)
    neurodegenerative diseases 30.2 6 17722060 (1), 14766349 (1), 16207717 (1), 18036576 (1)
    metastatic melanoma 29.4 12 11642609 (2), 9733794 (1), 15523674 (1), 16306050 (1) (see all 10)
    memory disorders 28.9 2 16266283 (1), 12556206 (1)

    Genetic Association Database (GAD): CREB1
    Human Genome Epidemiology (HuGE) Navigator: CREB1 (33 documents)

    Export disorders for CREB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CREB1 gene, integrated from 9 sources (see all 1846):
    (articles sorted by number of sources associating them with CREB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. (PubMed id 17300755)1, 4, 7, 9 Perlis R.H....Smoller J.W. (2007)
    2. Association study of CREB1 with Major Depressive Disorder and related phenotypes. (PubMed id 19194961)1, 4, 9 Hettema J.M....Chen X. (2009)
    3. Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. (PubMed id 15733869)1, 2, 9 David S. and Kalb R.G. (2005)
    4. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PubMed id 15454081)1, 2, 9 Screaton R.A.... Montminy M. (2004)
    5. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PubMed id 14506290)1, 2, 9 Iourgenko V.... Labow M.A. (2003)
    6. Transcriptional activation of egr-1 by granulocyte-macrophage colony- stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. (PubMed id 7608156)1, 2, 9 Lee H.-J.J.... Sakamoto K.M. (1995)
    7. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant r esponse in Mexican-Americans. (PubMed id 19844206)1, 4, 9 Dong C....Licinio J. (2009)
    8. Lithium response and genetic variation in the CREB family of genes. (PubMed id 18189280)1, 4, 9 Mamdani F....Turecki G. (2008)
    9. Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. (PubMed id 18678793)1, 4, 9 Perlis R.H....Breiter H.C. (2008)
    10. A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression. (PubMed id 17460549)1, 4, 9 Wilkie M.J....Smith G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1385 HGNC: 2345 AceView: CREB1 Ensembl:ENSG00000118260 euGenes: HUgn1385
    ECgene: CREB1 Kegg: 1385 H-InvDB: CREB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CREB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CREB1 gene:
    Search GeneIP for patents involving CREB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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