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Aliases for CREB1 Gene

Aliases for CREB1 Gene

  • CAMP Responsive Element Binding Protein 1 2 3
  • CAMP-Responsive Element-Binding Protein 1 3 4
  • CREB-1 3 4
  • Cyclic AMP-Responsive Element-Binding Protein 1 3
  • CAMP-Response Element-Binding Protein-1 3
  • Active Transcription Factor CREB 3
  • Transactivator Protein 3
  • CREB 3

External Ids for CREB1 Gene

Summaries for CREB1 Gene

Entrez Gene Summary for CREB1 Gene

  • This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREB1 Gene

CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include histiocytoma, angiomatoid fibrous, somatic and diabetic encephalopathy. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription cofactor activity. An important paralog of this gene is ATF1.

UniProtKB/Swiss-Prot for CREB1 Gene

  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells

Gene Wiki entry for CREB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREB1 Gene

Genomics for CREB1 Gene

Genomic Location for CREB1 Gene

Start:
207,529,737 bp from pter
End:
207,605,560 bp from pter
Size:
75,824 bases
Orientation:
Plus strand

Genomic View for CREB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREB1 Gene

Regulatory Elements for CREB1 Gene

Proteins for CREB1 Gene

  • Protein details for CREB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16220-CREB1_HUMAN
    Recommended name:
    Cyclic AMP-responsive element-binding protein 1
    Protein Accession:
    P16220
    Secondary Accessions:
    • P21934
    • Q6V963
    • Q9UMA7

    Protein attributes for CREB1 Gene

    Size:
    341 amino acids
    Molecular mass:
    36688 Da
    Quaternary structure:
    • Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.

    Three dimensional structures from OCA and Proteopedia for CREB1 Gene

    Alternative splice isoforms for CREB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CREB1 Gene

Proteomics data for CREB1 Gene at MOPED

Post-translational modifications for CREB1 Gene

  • Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
  • Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys136 and Lys330

No data available for DME Specific Peptides for CREB1 Gene

Domains for CREB1 Gene

Gene Families for CREB1 Gene

HGNC:
  • bZIP :basic leucine zipper proteins

UniProtKB/Swiss-Prot:

CREB1_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • P16220
  • Contains 1 KID (kinase-inducible) domain.:
    • P16220
Family:
  • Belongs to the bZIP family.:
    • P16220
genes like me logo Genes that share domains with CREB1: view

Function for CREB1 Gene

Molecular function for CREB1 Gene

GENATLAS Biochemistry: cAMP response element binding protein 1 (transcription regulator)
UniProtKB/Swiss-Prot Function: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells

Gene Ontology (GO) - Molecular Function for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9065434
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19861239
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC --
GO:0001102 RNA polymerase II activating transcription factor binding IPI 19861239
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA 19861239
genes like me logo Genes that share ontologies with CREB1: view
genes like me logo Genes that share phenotypes with CREB1: view

Animal Models for CREB1 Gene

MGI Knock Outs for CREB1:

Transcription Factor Targeting for CREB1 Gene

Selected GeneGlobe predicted Target genes for CREB1
Targeting motifs for CREB1 Gene
HOMER Transcription Factor Regulatory Elements motif CREB1
  • Consensus sequence: CGGTGACGTCAC Submotif: canonical Cell Type: NA

No data available for Enzyme Numbers (IUBMB) for CREB1 Gene

Localization for CREB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREB1 Gene COMPARTMENTS Subcellular localization image for CREB1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin --
GO:0005634 nucleus IDA 8798441
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex --
GO:0005719 nuclear euchromatin IDA 19861239
genes like me logo Genes that share ontologies with CREB1: view

Pathways for CREB1 Gene

SuperPathways for CREB1 Gene

Superpath Contained pathways
1 Ca-dependent events
2 PI-3K cascade
3 Signaling by FGFR
4 Toll Like Receptor 7/8 (TLR7/8) Cascade
5 Post NMDA receptor activation events
genes like me logo Genes that share pathways with CREB1: view

Gene Ontology (GO) - Biological Process for CREB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter IDA 19861239
genes like me logo Genes that share ontologies with CREB1: view

Compounds for CREB1 Gene

(3) HMDB Compounds for CREB1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Magnesium
  • Magnesium
7439-95-4

(2) Drugbank Compounds for CREB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target activator
Naloxone
  • EN 1530 Base
465-65-6 target other/unknown

(140) Novoseek inferred chemical compound relationships for CREB1 Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 89.2 167
forskolin 76.8 100
pd 98,059 65.9 30
sb 203580 59.7 18
na-mda 59.6 6

(2) PharmGKB related drug/compound annotations for CREB1 Gene

Drug/compound Annotation
antidepressants CA
citalopram CA
genes like me logo Genes that share compounds with CREB1: view

Transcripts for CREB1 Gene

Unigene Clusters for CREB1 Gene

CAMP responsive element binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CREB1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - -
SP10:

Relevant External Links for CREB1 Gene

GeneLoc Exon Structure for
CREB1
ECgene alternative splicing isoforms for
CREB1

Expression for CREB1 Gene

mRNA expression in normal human tissues for CREB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREB1 Gene

SOURCE GeneReport for Unigene cluster for CREB1 Gene Hs.516646

genes like me logo Genes that share expressions with CREB1: view

Orthologs for CREB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREB1 36
  • 99.9 (n)
  • 100 (a)
CREB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREB1 36
  • 95.38 (n)
  • 99.08 (a)
CREB1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREB1 36
  • 96.09 (n)
  • 100 (a)
CREB1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creb1 36
  • 95.31 (n)
  • 99.71 (a)
Creb1 16
Creb1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREB1 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREB1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creb1 36
  • 95.31 (n)
  • 99.12 (a)
chicken
(Gallus gallus)
Aves CREB1 36
  • 85.73 (n)
  • 98.78 (a)
CREB1 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREB1 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia creb1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia creb1 36
  • 82.47 (n)
  • 96.94 (a)
Str.10048 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6298 36
zebrafish
(Danio rerio)
Actinopterygii creb1a 36
  • 76.52 (n)
  • 91.19 (a)
creb1a 37
  • 91 (a)
OneToMany
creb1b 37
  • 91 (a)
OneToMany
zgc55598 36
fruit fly
(Drosophila melanogaster)
Insecta CrebB-17A 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crh-1 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.714 37
  • 45 (a)
OneToMany
Species with no ortholog for CREB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CREB1 Gene

ENSEMBL:
Gene Tree for CREB1 (if available)
TreeFam:
Gene Tree for CREB1 (if available)

Paralogs for CREB1 Gene

Paralogs for CREB1 Gene

Pseudogenes.org Pseudogenes for CREB1 Gene

genes like me logo Genes that share paralogs with CREB1: view

Variants for CREB1 Gene

Sequence variations from dbSNP and Humsavar for CREB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6785 -- 207,603,273(+) AGAAT(A/G)GTAGC utr-variant-3-prime, nc-transcript-variant
rs889895 -- 207,534,205(-) GCACT(C/T)GACAC intron-variant
rs1045780 -- 207,602,426(+) GAACA(A/G)TCTTT utr-variant-3-prime, nc-transcript-variant
rs1045790 -- 207,603,073(+) ATGTT(G/T)CTATT utr-variant-3-prime, nc-transcript-variant
rs1050641 -- 207,530,072(+) GAGAG(A/G)ATAAA utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CREB1 Gene

Variant ID Type Subtype PubMed ID
nsv821888 CNV Gain 20364138
nsv3131 CNV Loss 18451855

Relevant External Links for CREB1 Gene

HapMap Linkage Disequilibrium report
CREB1
Human Gene Mutation Database (HGMD)
CREB1

Disorders for CREB1 Gene

(1) OMIM Diseases for CREB1 Gene (123810)

UniProtKB/Swiss-Prot

CREB1_HUMAN
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
  • Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia. {ECO:0000269 PubMed:22267179}.

(93) Novoseek inferred disease relationships for CREB1 Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 78 17
leukemogenesis 39.4 6
sarcoma clear cell 37.4 3
drug addiction 35.3 5
nonfunctioning pituitary tumor 33 1

Relevant External Links for CREB1

Genetic Association Database (GAD)
CREB1
Human Genome Epidemiology (HuGE) Navigator
CREB1
genes like me logo Genes that share disorders with CREB1: view

Publications for CREB1 Gene

  1. Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. (PMID: 17300755) Perlis R.H. … Smoller J.W. (Biol. Psychiatry 2007) 3 23 25 49
  2. CREB is a regulatory target for the protein kinase Akt/PKB. (PMID: 9829964) Du K. … Montminy M. (J. Biol. Chem. 1998) 3 4 23
  3. Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. (PMID: 12552083) Comerford K.M. … Taylor C.T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. (PMID: 15454081) Screaton R.A. … Montminy M. (Cell 2004) 3 4 23
  5. Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. (PMID: 15733869) David S. … Kalb R.G. (FEBS Lett. 2005) 3 4 23

Products for CREB1 Gene

Sources for CREB1 Gene

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