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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CRCT1 Gene

protein-coding GIFtS: 43
GCID: GC01P152486

cysteine-rich C-terminal 1

(Previous name: chromosome 1 open reading frame 42 )
(Previous symbol: C1orf42)

Explore 4 diseases affiliated with
CRCT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cysteine-Rich C-Terminal 1¹ ²		Chromosome 1 Open Reading Frame 42¹
C1orf42¹ ² ³		Cysteine-Rich C-Terminal Protein 1²
NICE-1¹ ²		NICE1³
Protein NICE-1² ³

External Ids:	HGNC: 29875¹	Entrez Gene: 54544²	Ensembl: ENSG00000169509⁷	UniProtKB: Q9UGL9³

ORGUL members:
	NONCODE:n338233

Export aliases for CRCT1 gene to outside databases

Previous GC identifers: GC01P150756 GC01P123860

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRCT1 gene promoter:
HFH-3 C/EBPbeta AML1a p53 JunB GATA-1 FOXI1 Ik-2 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CRCT1 promoter sequence

Search SABiosciences Chromatin IP Primers for CRCT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRCT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

CRCT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRCT1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P152486: view genomic region (about GC identifiers)

Start:	152,486,978 bp from pter	End:	152,488,486 bp from pter
Size:	1,509 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CRCT1_HUMAN, Q9UGL9 (See protein sequence)

Recommended Name: Cysteine-rich C-terminal protein 1

Size: 99 amino acids; 9736 Da

Secondary accessions: A4QN00 Q6IAD7

Explore the universe of human proteins at neXtProt for CRCT1: NX_Q9UGL9

CRCT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061933.1

ENSEMBL proteins:

ENSP00000357779

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRCT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR026075 SPRR/LCE

Graphical View of Domain Structure for InterPro Entry Q9UGL9

ProtoNet protein and cluster: Q9UGL9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

CRCT1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CRCT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/21 Interacting proteins for CRCT1 (Q9UGL9^{2, 3} ENSP00000357779⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APLP1	P51693²^,³	MINT-65725 I2D: score=4
CHD3	Q12873²^,³	MINT-65732 I2D: score=4
KIAA1377	Q9P2H0²^,³	MINT-65731 I2D: score=4
PTN	P21246²^,³	MINT-65724 I2D: score=4
TLE1	Q04724²^,³	MINT-65726 I2D: score=4

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for CRCT1
Search CenterWatch for drugs/clinical trials and news about CRCT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CRCT1 gene:

NM_019060.2

Unigene Cluster for CRCT1:

Cysteine-rich C-terminal 1

Hs.110196 [show with all ESTs]

Unigene Representative Sequence: AJ243662

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000368790(uc001ezz.3)

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		hsa-let-7d hsa-miR-106a hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-520g

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Additional cDNA sequence:

AJ243662.1 BC119710.2 CR457218.1

1 DOTS entry:

DT.309992

15 AceView cDNA sequences:

AI096376 AW450170 BX279681 W67778 BG696730 NM_019060 AJ243662 CR457218

AA723264 AA009484 W72809 W67816 W96216 W96310 BE715813

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRCT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGGGACAC

About this image

CRCT1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CRCT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRCT1

SOURCE GeneReport for Unigene cluster: Hs.110196

SABiosciences Custom PCR Arrays for CRCT1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for CRCT1 (if available)
TreeFam Gene Tree for CRCT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CRCT1 gene

LCE2B² LCE3C² LCE2C² LCE3D² LCE5A² LCE3E² LCE1B² LCE4A²

LCE3A² LCE1A² LCE1E² LCE2A² LCE1D² LCE1C² LCE1F² LCE3B²

LCE2D²

CRCT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183199502^1,2		--	152485004(+)	`AATTGA/CTTGTC`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs188132869^1,2		--	152485063(+)	`ATAAAA/TGGACA`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs147301080^1,2		--	152485086(+)	`CTGATC/TATTAT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs192706428^1,2		--	152485136(+)	`GGGTGA/GGCAGT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs3753451^1,2	C,F,A,H,	--	152485227(-)	`TTCTCC/AGTTCT`	1	--	us2k¹		29		EA NA NS WA CSA	4324
rs73004851^1,2	C,F,	--	152485240(+)	`ACACCC/TTTCTT`	1	--	us2k¹		4		WA CSA	124
rs182209825^1,2		--	152485356(+)	`CTGTGA/TTGGGT`	1	--	us2k¹		0	--	--	--	--
rs187565910^1,2		--	152485386(+)	`TAGGAA/GTGGGC`	1	--	us2k¹		0	--	--	--	--
rs4845441^1,2	C,F,A,H,	--	152485421(+)	`ATGTAT/CCTAGA`	1	--	us2k¹		14		NS EA NA WA CSA	732
rs192560989^1,2		--	152485482(+)	`AACAAC/TTGATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CRCT1 (152486978 - 152488486 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CRCT1
2 CNVs: 3314 8333

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRCT1 for disorders About GeneDecksing

4 diseases for CRCT1: About MalaCards

cervical squamous cell carcinoma squamous cell carcinoma cervicitis carcinoma

Export disorders for CRCT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CRCT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CRCT1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)^{1, 2, 3} Marenholz I....Mischke D. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Meta-analysis of genome-wide association studies of as thma in ethnically diverse North American populations. (PubMed id 21804549)¹ Torgerson D.G....Nicolae D.L. (2011)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54544	HGNC: 29875	AceView: C1orf42	Ensembl:ENSG00000169509	euGenes: HUgn54544
ECgene: CRCT1	H-InvDB: CRCT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CRCT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CRCT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CRCT1 gene:
Search GeneIP for patents involving CRCT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CRCT1

	SwitchGear 3'UTR luciferase reporter plasmids for CRCT1
	SwitchGear Promoter luciferase reporter plasmids for CRCT1

ThermoFisher Antibody for CRCT1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCT1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CRCT1 Gene

cysteine-rich C-terminal 1

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CRCT1 Gene

cysteine-rich C-terminal 1

Aliasesfor CRCT1 gene

Summariesfor CRCT1 gene

Genomic Viewsfor CRCT1 gene

Proteinsfor CRCT1 gene

Protein Domains /Familiesfor CRCT1 gene

Functionfor CRCT1 gene

Pathways & Interactionsfor CRCT1 gene

Drugs & Compoundsfor CRCT1 gene

Transcriptsfor CRCT1 gene

Expression for CRCT1 gene

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Paralogsfor CRCT1 gene

Genomic Variantsfor CRCT1 gene

Disorders / Diseasesfor CRCT1 gene

Publicationsfor CRCT1 gene

External Searches for CRCT1 gene

Genome Databases showing CRCT1 gene

Other Databases showing CRCT1 gene

Specialized Databases showing CRCT1 gene

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Productsfor CRCT1 gene

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Aliases
for CRCT1 gene

Summaries
for CRCT1 gene

Genomic Views
for CRCT1 gene

Proteins
for CRCT1 gene

Protein Domains /
Families
for CRCT1 gene

Function
for CRCT1 gene

Pathways & Interactions
for CRCT1 gene

Drugs & Compounds
for CRCT1 gene

Transcripts
for CRCT1 gene

Expression
for CRCT1 gene

Orthologs
for CRCT1 gene

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for CRCT1 gene

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for CRCT1 gene

Disorders / Diseases
for CRCT1 gene

Publications
for CRCT1 gene

Intellectual Property
for CRCT1 gene

Products
for CRCT1 gene