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Aliases for CRCT1 Gene

Aliases for CRCT1 Gene

  • Cysteine-Rich C-Terminal 1 2 3
  • Protein NICE-1 3 4
  • C1orf42 3 4
  • Chromosome 1 Open Reading Frame 42 2
  • NICE-1 3
  • NICE1 4

External Ids for CRCT1 Gene

Previous HGNC Symbols for CRCT1 Gene

  • C1orf42

Previous GeneCards Identifiers for CRCT1 Gene

  • GC01P150756
  • GC01P152486
  • GC01P123860

Summaries for CRCT1 Gene

GeneCards Summary for CRCT1 Gene

CRCT1 (Cysteine-Rich C-Terminal 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCT1 Gene

Genomics for CRCT1 Gene

Regulatory Elements for CRCT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CRCT1 Gene

Chromosome:
1
Start:
152,514,502 bp from pter
End:
152,516,010 bp from pter
Size:
1,509 bases
Orientation:
Plus strand

Genomic View for CRCT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCT1 Gene

Proteins for CRCT1 Gene

  • Protein details for CRCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGL9-CRCT1_HUMAN
    Recommended name:
    Cysteine-rich C-terminal protein 1
    Protein Accession:
    Q9UGL9
    Secondary Accessions:
    • A4QN00
    • Q6IAD7

    Protein attributes for CRCT1 Gene

    Size:
    99 amino acids
    Molecular mass:
    9736 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRCT1 Gene

Proteomics data for CRCT1 Gene at MOPED

Post-translational modifications for CRCT1 Gene

No Post-translational modifications

Other Protein References for CRCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRCT1 Gene

Domains & Families for CRCT1 Gene

Protein Domains for CRCT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRCT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRCT1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CRCT1 Gene

Function for CRCT1 Gene

Gene Ontology (GO) - Molecular Function for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRCT1: view

Phenotypes for CRCT1 Gene

GenomeRNAi human phenotypes for CRCT1:
genes like me logo Genes that share phenotypes with CRCT1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRCT1 Gene

Localization for CRCT1 Gene

Gene Ontology (GO) - Cellular Components for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CRCT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CRCT1 Gene

Pathways & Interactions for CRCT1 Gene

SuperPathways for CRCT1 Gene

No Data Available

Interacting Proteins for CRCT1 Gene

Gene Ontology (GO) - Biological Process for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation IBA --
genes like me logo Genes that share ontologies with CRCT1: view

No data available for Pathways by source and SIGNOR curated interactions for CRCT1 Gene

Drugs & Compounds for CRCT1 Gene

No Compound Related Data Available

Transcripts for CRCT1 Gene

mRNA/cDNA for CRCT1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRCT1 Gene

Cysteine-rich C-terminal 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CRCT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRCT1 Gene

No ASD Table

Relevant External Links for CRCT1 Gene

GeneLoc Exon Structure for
CRCT1
ECgene alternative splicing isoforms for
CRCT1

Expression for CRCT1 Gene

mRNA expression in normal human tissues for CRCT1 Gene

mRNA differential expression in normal tissues according to GTEx for CRCT1 Gene

This gene is overexpressed in Esophagus - Mucosa (x26.4), Vagina (x9.2), and Cervix - Ectocervix (x8.1).

Protein differential expression in normal tissues from HIPED for CRCT1 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRCT1 Gene



SOURCE GeneReport for Unigene cluster for CRCT1 Gene Hs.110196

genes like me logo Genes that share expression patterns with CRCT1: view

Protein tissue co-expression partners for CRCT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CRCT1 Gene

Orthologs for CRCT1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CRCT1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Crct1 16
Species with no ortholog for CRCT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRCT1 Gene

ENSEMBL:
Gene Tree for CRCT1 (if available)
TreeFam:
Gene Tree for CRCT1 (if available)

Paralogs for CRCT1 Gene

No data available for Paralogs for CRCT1 Gene

Variants for CRCT1 Gene

Sequence variations from dbSNP and Humsavar for CRCT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs477621 -- 152,513,776(-) TGTGC(A/G)GGACA upstream-variant-2KB
rs557057 -- 152,514,178(-) CAATA(C/T)ACACA upstream-variant-2KB
rs1053588 -- 152,515,587(-) TGTCG(A/G/T)CGGCG synonymous-codon, reference
rs1053590 -- 152,515,952(+) AAATG(C/T)CTATT utr-variant-3-prime
rs2282296 -- 152,515,503(-) GAGCC(A/G)CAGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CRCT1 Gene

Variant ID Type Subtype PubMed ID
esv2750810 CNV Gain 17911159
dgv129e1 CNV Complex 17122850
dgv130e1 CNV Complex 17122850
dgv131e1 CNV Complex 17122850
nsv524241 CNV Loss 19592680
nsv518413 CNV Loss 19592680

Variation tolerance for CRCT1 Gene

Residual Variation Intolerance Score: 62.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRCT1 Gene

HapMap Linkage Disequilibrium report
CRCT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRCT1 Gene

Disorders for CRCT1 Gene

Relevant External Links for CRCT1

Genetic Association Database (GAD)
CRCT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRCT1
genes like me logo Genes that share disorders with CRCT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRCT1 Gene

Publications for CRCT1 Gene

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 67
  4. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. (PMID: 21804549) Torgerson D.G. … Nicolae D.L. (Nat. Genet. 2011) 67
  5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 67

Products for CRCT1 Gene

Sources for CRCT1 Gene

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