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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRCT1 Gene

protein-coding   GIFtS: 44
GCID: GC01P152486

Cysteine-Rich C-Terminal 1

(Previous name: chromosome 1 open reading frame 42)
(Previous symbol: C1orf42)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cysteine-Rich C-Terminal 11 2     NICE-12
C1orf421 2 3     Cysteine-Rich C-Terminal Protein 12
Protein NICE-12 3     NICE13
Chromosome 1 Open Reading Frame 421     

External Ids:    HGNC: 298751   Entrez Gene: 545442   Ensembl: ENSG000001695097   UniProtKB: Q9UGL93   
ORGUL members:         
NONCODE14:n338233      

Export aliases for CRCT1 gene to outside databases

Previous GC identifers: GC01P150756 GC01P123860


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CRCT1 Gene: 
CRCT1 (cysteine-rich C-terminal 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CRCT1 include cervical squamous cell carcinoma, and squamous cell carcinoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRCT1 gene promoter:
         HFH-3   C/EBPbeta   AML1a   p53   JunB   GATA-1   FOXI1   Ik-2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRCT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRCT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRCT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CRCT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRCT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P152486:  view genomic region     (about GC identifiers)

Start:
152,486,978 bp from pter      End:
152,488,486 bp from pter
Size:
1,509 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRCT1_HUMAN, Q9UGL9 (See protein sequence)
Recommended Name: Cysteine-rich C-terminal protein 1  
Size: 99 amino acids; 9736 Da
Secondary accessions: A4QN00 Q6IAD7

Explore the universe of human proteins at neXtProt for CRCT1: NX_Q9UGL9

Explore proteomics data for CRCT1 at MOPED 

CRCT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CRCT1 Protein Expression

REFSEQ proteins: NP_061933.1  
ENSEMBL proteins: 
 ENSP00000357779  

Human Recombinant Protein Products for CRCT1: 
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Cloud-Clone Corp. ELISAs for CRCT1 
Cloud-Clone Corp. CLIAs for CRCT1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026075 SPRR/LCE

Graphical View of Domain Structure for InterPro Entry Q9UGL9

ProtoNet protein and cluster: Q9UGL9


CRCT1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CRCT1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRCT1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRCT1 
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miRNA
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8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CRCT1 (see all 22):
hsa-let-7d hsa-miR-106a hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-520g
SwitchGear 3'UTR luciferase reporter plasmidCRCT1 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for CRCT1
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                     Customized lentivirus expression plasmids for stable overexpression of CRCT1 

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRCT1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRCT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/21 Interacting proteins for CRCT1 (Q9UGL92, 3 ENSP000003577794) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
APLP1P516932, 3MINT-65725 I2D: score=4 
CHD3Q128732, 3MINT-65732 I2D: score=4 
KIAA1377Q9P2H02, 3MINT-65731 I2D: score=4 
PTNP212462, 3MINT-65724 I2D: score=4 
TLE1Q047242, 3MINT-65726 I2D: score=4 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRCT1

Search CenterWatch for drugs/clinical trials and news about CRCT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CRCT1 gene: 
NM_019060.2  

Unigene Cluster for CRCT1:

Cysteine-rich C-terminal 1
Hs.110196  [show with all ESTs]
Unigene Representative Sequence: AJ243662
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000368790(uc001ezz.3)
miRNA
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8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CRCT1 (see all 22):
hsa-let-7d hsa-miR-106a hsa-let-7c hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-93 hsa-miR-520g
SwitchGear 3'UTR luciferase reporter plasmidCRCT1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CRCT1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRCT1
Clone
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OriGene clones in human, mouse for CRCT1 (see all 4)
OriGene ORF clones in mouse, rat for CRCT1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CRCT1 (NM_019060)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRCT1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCT1
Sirion Biotech Customized lentivirus for stable overexpression of CRCT1 
                     Customized lentivirus expression plasmids for stable overexpression of CRCT1 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for CRCT1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRCT1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRCT1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRCT1

Additional mRNA sequence: 

AJ243662.1 BC119710.2 CR457218.1 

1 DOTS entry:

DT.309992 

15 AceView cDNA sequences:

W67778 AJ243662 AI096376 BX279681 AW450170 NM_019060 BG696730 CR457218 
AA009484 W72809 AA723264 W96310 W67816 W96216 BE715813 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CRCT1 expression in normal human tissues (normalized intensities)      CRCT1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGTGGGACAC
CRCT1 Expression
About this image


CRCT1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Lung (Respiratory System)    fully expand to see all 3 entries
         Basal Cells Respiratory Bronchioles
         visceral organ/lung/right lung   
 
 Epidermis (Integumentary System)
         Human EpiDermal Keratinocytes-adult (HEK-a)   
 
 Epithelium (Endocrine System)
         Human Prostate Epithelial Cells (HPrEpiC)   
 
 Oral Cavity (Gastrointestinal Tract)
         Tongue   
 
 Prostate (Endocrine System)
         Human Prostate Epithelial Cells (HPrEpiC)   

See CRCT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRCT1

SOURCE GeneReport for Unigene cluster: Hs.110196
    SABiosciences Custom PCR Arrays for CRCT1
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CRCT1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRCT1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRCT1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRCT1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRCT1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CRCT1 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Crct11 , 5 cysteine-rich C-terminal 11, 5 77.9(n)1
82.61(a)1
  3 (40.14 cM)5
741751  NM_028798.31  NP_083074.21 
 930142055 


ENSEMBL Gene Tree for CRCT1 (if available)
TreeFam Gene Tree for CRCT1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/119 SNPs in CRCT1 are shown (see all 119)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs37534511,2
C,F,A,H--152485227(-) TTCTCC/AGTTCT 1 -- us2k129Minor allele frequency- A:0.37EA NA NS WA CSA 4324
rs730048511,2
C,F--152485240(+) ACACCC/TTTCTT 1 -- us2k14Minor allele frequency- T:0.25WA CSA 124
rs106688761,2
C--152485279(+) GTGTG-/GT/T  
  G
/TGTG
CAGTG
1 -- us2k11NA 2
rs1822098251,2
--152485356(+) CTGTGA/TTGGGT 1 -- us2k10--------
rs1875659101,2
--152485386(+) TAGGAA/GTGGGC 1 -- us2k10--------
rs48454411,2
C,F,A,H--152485421(+) ATGTAT/CCTAGA 1 -- us2k114Minor allele frequency- C:0.46NS EA NA WA CSA 732
rs1925609891,2
--152485482(+) AACAAC/TTGATG 1 -- us2k10--------
rs48454421,2
C,F,A,H--152485545(+) TCATAA/GGATGC 1 -- us2k118Minor allele frequency- G:0.33NA EA NS WA CSA 788
rs1842416481,2
C--152485549(+) AGGATA/GCCCAC 1 -- us2k10--------
rs106664681,2
C--152485608(+) AAACGTTC/-TTCTT 1 -- cds11Minor allele frequency- -:0.50NA 2

HapMap Linkage Disequilibrium report for CRCT1 (152486978 - 152488486 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for CRCT1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv518413CNV Loss19592680
nsv524241CNV Loss19592680
esv2750810CNV Gain17911159
dgv131e1CNV Complex17122850
dgv130e1CNV Complex17122850
dgv129e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for CRCT1:    About MalaCards
cervical squamous cell carcinoma    squamous cell carcinoma    cervicitis


CRCT1 for disorders           About GeneDecksing

Genetic Association Database (GAD): CRCT1

Export disorders for CRCT1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CRCT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CRCT1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)1, 2, 3 Marenholz I....Mischke D. (2001)
  2. Meta-analysis of genome-wide association studies of as thma in ethnically diverse North American populations. (PubMed id 21804549)1, 4 Torgerson D.G....Nicolae D.L. (2011)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
  5. Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)4 Eriksson N....Mountain J. (2010)
  6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 54544 HGNC: 29875 AceView: C1orf42 Ensembl:ENSG00000169509 euGenes: HUgn54544
ECgene: CRCT1 H-InvDB: CRCT1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CRCT1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CRCT1 gene:
Search GeneIP for patents involving CRCT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in CRCT1 promoter
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 RT2 qPCR Primer Assay in human, mouse, rat CRCT1
 Search GNC Networks for CRCT1
 SABiosciences Custom PCR Arrays for CRCT1
 Search Tocris compounds for CRCT1
 Browse Sino Biological Proteins and Antibodies
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
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 See all of Abcam's Antibodies, Kits and Proteins for CRCT1
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 Proteins for CRCT1
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 ELISAs for CRCT1
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 Search LifeMap BioReagents cell lines for CRCT1
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRCT1
 SwitchGear 3'UTR luciferase reporter plasmids for CRCT1
 SwitchGear Promoter luciferase reporter plasmids for CRCT1
 ThermoFisher Antibody for CRCT1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCT1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CRCT1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRCT1
Customized:
 lentivirus for stable overexpression of CRCT1
 lentivirus expression plasmids for stable overexpression of CRCT1
 adenovirus for overexpression of CRCT1
 LSBio Antibodies in human, mouse, rat for CRCT1
Customized transgenic rodents for:
 Humanization
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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