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Aliases for CRCT1 Gene

Aliases for CRCT1 Gene

  • Cysteine Rich C-Terminal 1 2 3 5
  • Protein NICE-1 3 4
  • C1orf42 3 4
  • Chromosome 1 Open Reading Frame 42 2
  • Cysteine-Rich C-Terminal Protein 1 3
  • Cysteine-Rich C-Terminal 1 2
  • NICE-1 3
  • NICE1 4

External Ids for CRCT1 Gene

Previous HGNC Symbols for CRCT1 Gene

  • C1orf42

Previous GeneCards Identifiers for CRCT1 Gene

  • GC01P150756
  • GC01P152486
  • GC01P123860

Summaries for CRCT1 Gene

GeneCards Summary for CRCT1 Gene

CRCT1 (Cysteine Rich C-Terminal 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCT1 Gene

Genomics for CRCT1 Gene

Regulatory Elements for CRCT1 Gene

Enhancers for CRCT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F152459 1 Ensembl ENCODE 10.3 -54.2 -54199 1.4 SIX4 HDGF CTCF MXI1 PKNOX1 MAX YBX1 RAD21 ZFHX2 EGR1 CRCT1 LCE5A S100A11 RPTN CRNN PIR42758
GH01F152461 0.7 ENCODE 10.3 -52.7 -52743 0.2 SRF CTCF ZNF654 RFX1 HLF CEBPB CEBPG RAD21 GATA3 SMC3 CRCT1 LCE5A S100A11 RPTN PIR42758
GH01F152458 0.7 ENCODE 9.9 -55.9 -55923 0.2 CTCF ZNF654 PKNOX1 TRIM22 RAD21 RFX5 CBX1 GATA3 ZNF341 ZNF143 FLG2 CRCT1 RPTN PIR42758 LCE5A
GH01F152480 0.4 ENCODE 11.1 -34.2 -34243 0.2 CTCF GABPB1 LCE5A CRCT1 LCE3A LCE3D HRNR CRNN PIR42758
GH01F152515 0.6 Ensembl 0.8 +1.0 999 0.6 ZFHX2 GLIS2 SP3 SUZ12 SCRT2 SP2 EGR2 CRNN CRCT1 GC01P152531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRCT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CRCT1 Gene

Chromosome:
1
Start:
152,514,502 bp from pter
End:
152,516,010 bp from pter
Size:
1,509 bases
Orientation:
Plus strand

Genomic View for CRCT1 Gene

Genes around CRCT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRCT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCT1 Gene

Proteins for CRCT1 Gene

  • Protein details for CRCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGL9-CRCT1_HUMAN
    Recommended name:
    Cysteine-rich C-terminal protein 1
    Protein Accession:
    Q9UGL9
    Secondary Accessions:
    • A4QN00
    • Q6IAD7

    Protein attributes for CRCT1 Gene

    Size:
    99 amino acids
    Molecular mass:
    9736 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRCT1 Gene

Post-translational modifications for CRCT1 Gene

No Post-translational modifications

Other Protein References for CRCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRCT1 Gene

Domains & Families for CRCT1 Gene

Protein Domains for CRCT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRCT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRCT1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CRCT1 Gene

Function for CRCT1 Gene

Gene Ontology (GO) - Molecular Function for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRCT1: view
genes like me logo Genes that share phenotypes with CRCT1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRCT1 Gene

Localization for CRCT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRCT1 gene
Compartment Confidence
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CRCT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRCT1 Gene

Pathways & Interactions for CRCT1 Gene

SuperPathways for CRCT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation IBA --
genes like me logo Genes that share ontologies with CRCT1: view

No data available for Pathways by source and SIGNOR curated interactions for CRCT1 Gene

Transcripts for CRCT1 Gene

mRNA/cDNA for CRCT1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRCT1 Gene

Cysteine-rich C-terminal 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRCT1 Gene

No ASD Table

Relevant External Links for CRCT1 Gene

GeneLoc Exon Structure for
CRCT1
ECgene alternative splicing isoforms for
CRCT1

Expression for CRCT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRCT1 Gene

mRNA differential expression in normal tissues according to GTEx for CRCT1 Gene

This gene is overexpressed in Esophagus - Mucosa (x26.4), Vagina (x9.2), and Cervix - Ectocervix (x8.1).

Protein differential expression in normal tissues from HIPED for CRCT1 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRCT1 Gene



Protein tissue co-expression partners for CRCT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRCT1 Gene:

CRCT1

SOURCE GeneReport for Unigene cluster for CRCT1 Gene:

Hs.110196
genes like me logo Genes that share expression patterns with CRCT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CRCT1 Gene

Orthologs for CRCT1 Gene

Evolution for CRCT1 Gene

ENSEMBL:
Gene Tree for CRCT1 (if available)
TreeFam:
Gene Tree for CRCT1 (if available)

No data available for Orthologs for CRCT1 Gene

Paralogs for CRCT1 Gene

No data available for Paralogs for CRCT1 Gene

Variants for CRCT1 Gene

Sequence variations from dbSNP and Humsavar for CRCT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1053588 -- 152,515,587(-) TGTCG(A/G)CGGCG reference, synonymous-codon
rs1053590 -- 152,515,952(+) AAATG(C/T)CTATT utr-variant-3-prime
rs10666468 -- 152,513,132(+) AAACG(-/TTC)TTCTT upstream-variant-2KB
rs111942083 -- 152,516,022(+) ATTTG(C/T)TCTTC downstream-variant-500B
rs111996276 -- 152,514,702(+) ACTAA(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRCT1 Gene

Variant ID Type Subtype PubMed ID
nsv524241 CNV loss 19592680
nsv518413 CNV loss 19592680
esv2758970 CNV gain+loss 17122850
esv2750810 CNV gain 17911159
dgv415n100 CNV loss 25217958

Variation tolerance for CRCT1 Gene

Residual Variation Intolerance Score: 62.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRCT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRCT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRCT1 Gene

Disorders for CRCT1 Gene

Relevant External Links for CRCT1

Genetic Association Database (GAD)
CRCT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRCT1

No disorders were found for CRCT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRCT1 Gene

Publications for CRCT1 Gene

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 3 4 64
  2. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. (PMID: 21804549) Torgerson D.G. … Nicolae D.L. (Nat. Genet. 2011) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for CRCT1 Gene

Sources for CRCT1 Gene

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