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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRCP Gene

protein-coding   GIFtS: 52
GCID: GC07P065578

CGRP receptor component
 Explore 5 diseases affiliated with
CRCP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRCP    

Aliases
for CRCP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CGRP Receptor Component1 2     CGRPRCP2 3
CGRP-RCP1 2 3     CGRP-Receptor Component Protein2 3
RCP1 2 5     RNA Polymerase III Subunit C92 3
RCP91 2     DNA-Directed RNA Polymerase III Subunit RPC92
Calcitonin Gene-Related Peptide-Receptor Component Protein2 3     HsC173

External Ids:    HGNC: 178881   Entrez Gene: 272972   Ensembl: ENSG000002412587   OMIM: 6061215   UniProtKB: O755753   
ORGUL members:         
NONCODE:n407054    

Export aliases for CRCP gene to outside databases

Previous GC identifers: GC07P065216 GC07P061767


Summaries
for CRCP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRCP:
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that
increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been
characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as
5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts
as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as
template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-
Kappa-B through the RIG-I pathway (By similarity)
Function: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness
in a variety of tissues

Gene Wiki entry for CRCP (RCP9)


Genomic Views
for CRCP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRCP gene promoter:
         FOXF2   FOXO3b   C/EBPalpha   Ik-2   FOXC1   HFH-1   FOXO4   FOXO3a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRCP promoter sequence
   Search SABiosciences Chromatin IP Primers for CRCP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.1

CRCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRCP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P065578:  view genomic region     (about GC identifiers)

Start:
 65,579,591 bp from pter      End:
 65,619,555 bp from pter
Size:
 39,965 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 64,917,300-64,957,081     

Proteins
for CRCP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC9  
Size: 148 amino acids; 16871 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts
with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex
Subcellular location: Nucleus (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By
similarity)
Secondary accessions: A8MUZ4 A8MW23 B2R4H4 B4E198 Q3KRA3 Q5HYF1 Q8IXL4
Alternative splicing: 4 isoforms:  O75575-1   O75575-2   O75575-3   O75575-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRCP: NX_O75575

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75575

    • CRCP Protein expression data from MOPED and PaxDb:    About this image 
    CRCP Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001035737.1  NP_001035738.1  NP_001135886.1  NP_055293.1  

    ENSEMBL proteins: 
     ENSP00000353589   ENSP00000378736   ENSP00000388653   ENSP00000381674   ENSP00000340044  
     ENSP00000398605  

    Human Recombinant Protein Products for CRCP: 
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    Novus Biologicals CRCP Proteins
    Novus Biologicals CRCP Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CRCP
    Uscn Proteins for CRCP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009360DNA polymerase III complex IDA12482973

    CRCP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CRCP

    Protein Domains /
    Families
    for CRCP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CRCP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR010997 HRDC-like
     IPR005574 RNA_pol_II_Rpb4
     IPR006590 RNA_pol_II_Rpb4_core

    Graphical View of Domain Structure for InterPro Entry O75575

    ProtoNet protein and cluster: O75575

    UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
    Similarity: Belongs to the eukaryotic RPC9 RNA polymerase subunit family


    Function
    for CRCP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPC9_HUMAN, O75575
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as
    5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts
    as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as
    template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-
    Kappa-B through the RIG-I pathway (By similarity)
    Function: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness
    in a variety of tissues

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001635calcitonin gene-related polypeptide receptor activity IEA--
    GO:0003899DNA-directed RNA polymerase activity IDA12482973
    GO:0004948calcitonin receptor activity NAS8622957
         
    CRCP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CRCP:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CRCP 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): CRCP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRCP
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CRCP (see all 15):
    hsa-miR-30c hsa-miR-647 hsa-miR-1266 hsa-miR-30d hsa-miR-551b* hsa-miR-1305 hsa-miR-4261 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CRCP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRCP (see all 7)
    OriGene shRNA RFP: CRCP
    OriGene siRNA: CRCP
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CRCP 

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCP 

    Cell Line
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    Search LifeMap BioReagents cell lines for CRCP
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRCP


    Pathways & Interactions
    for CRCP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Calcium Regulation in the Cardiac Cell
    		Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CRCP 
        Myometrial Relaxation and Contraction Pathways


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRCP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CRCP (O755753 ENSP000003787364) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCRLQ166023, ENSP000003761774I2D: score=2 STRING: ENSP00000376177
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    POLR3HQ9Y5353, ENSP000003473454I2D: score=1 STRING: ENSP00000347345
    POLD3ENSP000002636814STRING: ENSP00000263681
    CHRAC1ENSP000002209134STRING: ENSP00000220913
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006383transcription from RNA polymerase III promoter IDA12482973
    GO:0006950response to stress ----
    GO:0006954inflammatory response ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007340acrosome reaction NAS10067875

    CRCP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRCP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRCP
    Search CenterWatch for drugs/clinical trials and news about CRCP / RPC9 

    Transcripts
    for CRCP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRCP gene (4 alternative transcripts): 
    NM_001040647.1  NM_001040648.1  NM_001142414.1  NM_014478.4  

    Unigene Cluster for CRCP:

    CGRP receptor component
    Hs.300684  [show with all ESTs]
    Unigene Representative Sequence: NR_024548
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360415(uc003tuv.3 uc003tus.3 uc011kdw.2 uc003tut.3 uc003tuu.3)
    ENST00000395326 ENST00000431089 ENST00000398684 ENST00000338592 ENST00000486848
    ENST00000492264 ENST00000415001

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): CRCP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRCP
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CRCP (see all 15):
    hsa-miR-30c hsa-miR-647 hsa-miR-1266 hsa-miR-30d hsa-miR-551b* hsa-miR-1305 hsa-miR-4261 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CRCP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRCP (see all 7)
    OriGene shRNA RFP: CRCP
    OriGene siRNA: CRCP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CRCP
    Sirion Biotech Custom design and validation of potent shRNA sequences against CRCP 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CRCP (NM_014478)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRCP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRCP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRCP

    Additional cDNA sequence: 

    AF073792.1 AK023295.1 AK290553.1 AK303737.1 AK311829.1 BC040107.1 BC105808.1 NR_024548.1 
    U51134.1 

    19 DOTS entries:

    DT.101970373  DT.91692222  DT.100706481  DT.91975813  DT.121127694  DT.100666867  DT.121127419  DT.40245789 
    DT.75102299  DT.100706480  DT.91745930  DT.100774554  DT.121127589  DT.121127596  DT.91857326  DT.91905208 
    DT.99951320  DT.100774553  DT.99979060 

    24/206 AceView cDNA sequences (see all 206):

    CR596171 BM469369 BP372476 BE563263 CR596097 AI937267 BM772619 CR619700 
    BM826079 CR607016 BE018013 CR591306 BX328836 CF127537 CR618306 BM794893 
    BE408667 CR618289 AI750589 CR619001 BM826643 AW137035 BQ954569 AI186427 

    GeneLoc Exon Structure


    Expression
    for CRCP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAAACCCC
    CRCP Expression
    About this image
    See CRCP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRCP

    SOURCE GeneReport for Unigene cluster: Hs.300684

    UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
    Tissue specificity: Ubiquitous. Most prevalent in testis

        SABiosciences Expression via Pathway-Focused PCR Array including CRCP: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CRCP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CRCP gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Crcp1 , 5 calcitonin gene-related peptide-receptor component protein less1, 5 83.78(n)1
    88.51(a)1    		   5 (68.42 cM)5
    129091  NM_007761.21  NP_031787.11 
     1300292905 
    chicken
    (Gallus gallus)    		 Aves CRCP1 CGRP receptor component 78.7(n)
    85.71(a)    		   396022  XM_415793.2  XP_415793.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC056658.12   -- 75.53(n)    BC056658.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.158892 Transcribed sequence with moderate similarity to protein refNP_055293.1 (H.sapiens) calcitonin gene-related peptide-receptor component protein [Homo sapiens] less 72.5(n)    BM531243.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rcp1 Receptor component protein 49.09(n)
    34.55(a)    		   32678  NM_206770.1  NP_996493.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea M106.76
    		 --
    		 38(a)
    		 1 ↔ 1
    		 II(10855582-10857119)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G289566
    AT5G629506
    		 RNA polymerase II, Rpb4, core protein
    		 26(a)
    24(a)
    		 many → 1
    many → 1
    		 3(10980700-10982244)
    5(25262179-25263901)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 DNA-directed RNA polymerase III subunit RPC9, puta...
    		 26(a)
    		 1 ↔ 1
    		 12(18282345-18284538)


    ENSEMBL Gene Tree for CRCP (if available)
    TreeFam Gene Tree for CRCP (if available) 

    Paralogs
    for CRCP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRCP gene
    18/33 SIMAP similar genes for CRCP using alignment to 3 protein entries:     RPC9_HUMAN (see all proteins) (see all similar genes):
    FAM175A    HOOK2    ERBB2    HKR1    LYRM4    ZNF410
    FAM3A    TNFRSF17    WARS    DYM    TCF4    TMEM44
    APOPT1    NEK4    C4orf21    LOC100506792    SYPL1    TMEM135

    CRCP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CRCP
    PGOHUM00000232838


    Genomic Variants
    for CRCP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/765 NCBI SNPs in CRCP are shown (see all 765)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1115234121,2
    		C--65577874(+) GCCCGG/CCTCGG 5 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1828082631,2
    		--65577877(+) CGCCTC/TGGCCT 5 -- us2k10--------
    rs126680101,2
    		C,H--65578066(+) atgagG/Tgactt 5 -- us2k10--------
    rs1148246451,2
    		F--65578167(+) TTGTAT/CTGCCA 5 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1916118831,2
    		--65578487(+) GCTGAG/TGAGGG 5 -- us2k10--------
    rs1837551881,2
    		--65578588(+) ATGGCA/GGGCAC 5 -- us2k10--------
    rs2013035581,2
    		--65578731(+) AAAAA-/AGAAAAA 5 -- us2k10--------
    rs759735541,2
    		C--65578732(+) AAAAAA/GAAAAA 5 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1474058531,2
    		--65578732(+) AAAAA-/GAAAAA 5 -- us2k10--------
    rs355105811,2
    		C,F--65578777(-) AGGTGC/TGCTCC 5 -- us2k18Minor allele frequency- T:0.26NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for CRCP (65579591 - 65619555 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CRCP
         1 CNV: 64850

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    Disorders / Diseases
    for CRCP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRCP for disorders           About GeneDecksing

    OMIM gene information: 606121    OMIM disorders: --

    5 diseases for CRCP:    About MalaCards
    cystic fibrosis    cryptorchidism    fibrosis    pancreatic cancer
    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: CRCP (2 documents)

    Export disorders for CRCP gene to outside databases

    Publications
    for CRCP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRCP gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CRCP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PubMed id 10067875)1, 2, 3, 9 Balkan W.... Roos B.A. (1999)
    2. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PubMed id 12482973)1, 2, 3, 9 Siaut M.... Conesa C. (2003)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2 Hu P....Hernandez N. (2002)
    7. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. (PubMed id 8622957)1, 3 Luebke A.E....Dickerson I.M. (1996)
    8. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. (PubMed id 17853344)1, 9 Goharkhay N....Wing D.A. (2007)
    9. The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. (PubMed id 11754963)1, 9 Prado M.A....Dickerson I.M. (2001)
    10. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. (PubMed id 10903324)1, 9 Evans B.N....Dickerson I.M. (2000)

    External Searches for CRCP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CRCP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27297 HGNC: 17888 AceView: ASLandRCP9 Ensembl:ENSG00000241258 euGenes: HUgn27297
    ECgene: CRCP H-InvDB: CRCP

    Other Databases showing CRCP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CRCP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRCP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CRCP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CRCP gene:
    Search GeneIP for patents involving CRCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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