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Aliases for CRCP Gene

Aliases for CRCP Gene

  • CGRP Receptor Component 2 3
  • Calcitonin Gene-Related Peptide-Receptor Component Protein 2 3 4
  • CGRP-Receptor Component Protein 3 4
  • RNA Polymerase III Subunit C9 3 4
  • CGRP-RCP 3 4
  • CGRPRCP 3 4
  • RCP 3 6
  • DNA-Directed RNA Polymerase III Subunit RPC9 3
  • HsC17 4
  • RCP9 3

External Ids for CRCP Gene

Summaries for CRCP Gene

Entrez Gene Summary for CRCP Gene

  • This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRCP Gene

CRCP (CGRP Receptor Component) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include nucleotide binding and calcitonin receptor activity.

UniProtKB/Swiss-Prot for CRCP Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

  • Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues

Gene Wiki entry for CRCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCP Gene

Genomics for CRCP Gene

Genomic Location for CRCP Gene

Start:
66,114,604 bp from pter
End:
66,154,568 bp from pter
Size:
39,965 bases
Orientation:
Plus strand

Genomic View for CRCP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCP Gene

Regulatory Elements for CRCP Gene

Proteins for CRCP Gene

  • Protein details for CRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75575-RPC9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC9
    Protein Accession:
    O75575
    Secondary Accessions:
    • A8MUZ4
    • A8MW23
    • B2R4H4
    • B4E198
    • Q3KRA3
    • Q5HYF1
    • Q8IXL4

    Protein attributes for CRCP Gene

    Size:
    148 amino acids
    Molecular mass:
    16871 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.

    Alternative splice isoforms for CRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRCP Gene

Proteomics data for CRCP Gene at MOPED

Post-translational modifications for CRCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRCP Gene

Domains for CRCP Gene

Protein Domains for CRCP Gene

UniProtKB/Swiss-Prot:

RPC9_HUMAN
Family:
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.:
    • O75575
genes like me logo Genes that share domains with CRCP: view

No data available for Gene Families for CRCP Gene

Function for CRCP Gene

Molecular function for CRCP Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
UniProtKB/Swiss-Prot Function: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues

Gene Ontology (GO) - Molecular Function for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0003824 catalytic activity --
GO:0003899 DNA-directed RNA polymerase activity IDA 12482973
genes like me logo Genes that share ontologies with CRCP: view

Phenotypes for CRCP Gene

GenomeRNAi human phenotypes for CRCP:
genes like me logo Genes that share phenotypes with CRCP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRCP Gene

Localization for CRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRCP Gene

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRCP Gene COMPARTMENTS Subcellular localization image for CRCP gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRCP: view

Pathways for CRCP Gene

genes like me logo Genes that share pathways with CRCP: view

Pathways by source for CRCP Gene

1 BioSystems pathway for CRCP Gene

Gene Ontology (GO) - Biological Process for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0006385 transcription elongation from RNA polymerase III promoter TAS --
GO:0006386 termination of RNA polymerase III transcription TAS --
genes like me logo Genes that share ontologies with CRCP: view

Transcripts for CRCP Gene

Unigene Clusters for CRCP Gene

CGRP receptor component:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRCP Gene

No ASD Table

Relevant External Links for CRCP Gene

GeneLoc Exon Structure for
CRCP
ECgene alternative splicing isoforms for
CRCP

Expression for CRCP Gene

mRNA expression in normal human tissues for CRCP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRCP Gene

SOURCE GeneReport for Unigene cluster for CRCP Gene Hs.300684

mRNA Expression by UniProt/SwissProt for CRCP Gene

O75575-RPC9_HUMAN
Tissue specificity: Ubiquitous. Most prevalent in testis.
genes like me logo Genes that share expressions with CRCP: view

Orthologs for CRCP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRCP 36
  • 99.77 (n)
  • 100 (a)
CRCP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CRCP 36
  • 88.06 (n)
  • 93.24 (a)
CRCP 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRCP 36
  • 90.02 (n)
  • 93.88 (a)
CRCP 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crcp 36
  • 83.78 (n)
  • 88.51 (a)
Crcp 16
Crcp 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRCP 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRCP 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crcp 36
  • 83.78 (n)
  • 87.16 (a)
chicken
(Gallus gallus)
Aves CRCP 36
  • 78.7 (n)
  • 85.71 (a)
CRCP 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crcp 36
  • 70.15 (n)
  • 78.36 (a)
zebrafish
(Danio rerio)
Actinopterygii crcp 36
  • 68.09 (n)
  • 74.47 (a)
crcp 37
  • 72 (a)
OneToOne
Dr.15889 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007220 36
  • 52.93 (n)
  • 44.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rcp 36
  • 48.23 (n)
  • 36.17 (a)
Rcp 37
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M106.7 37
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13606 36
Species with no ortholog for CRCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRCP Gene

ENSEMBL:
Gene Tree for CRCP (if available)
TreeFam:
Gene Tree for CRCP (if available)

Paralogs for CRCP Gene

Pseudogenes.org Pseudogenes for CRCP Gene

genes like me logo Genes that share paralogs with CRCP: view

No data available for Paralogs for CRCP Gene

Variants for CRCP Gene

Sequence variations from dbSNP and Humsavar for CRCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs160637 -- 66,119,331(-) aagtg(A/G)tgcac intron-variant
rs160638 -- 66,118,101(-) acttg(G/T)taggc intron-variant
rs160639 -- 66,115,000(+) TTTCG(C/G)CCGAG intron-variant
rs160640 -- 66,114,305(+) cagag(A/G)ttgca upstream-variant-2KB
rs186378 -- 66,117,071(-) acaat(G/T)tggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRCP Gene

Variant ID Type Subtype PubMed ID
esv2664145 CNV Deletion 23128226
nsv511363 CNV Loss 21212237
esv27174 CNV Loss 19812545
nsv511969 CNV Loss 21212237
esv2734594 CNV Deletion 23290073
esv2656542 CNV Deletion 23128226
dgv1113n67 CNV Loss 20364138
esv1751958 CNV Insertion 17803354
esv2674673 CNV Deletion 23128226

Relevant External Links for CRCP Gene

HapMap Linkage Disequilibrium report
CRCP

Disorders for CRCP Gene

Relevant External Links for CRCP

Genetic Association Database (GAD)
CRCP
Human Genome Epidemiology (HuGE) Navigator
CRCP
genes like me logo Genes that share disorders with CRCP: view

No data available for UniProtKB/Swiss-Prot for CRCP Gene

Publications for CRCP Gene

  1. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PMID: 10067875) Balkan W. … Roos B.A. (Endocrinology 1999) 2 3 4 23
  2. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PMID: 12482973) Siaut M. … Conesa C. (Mol. Cell. Biol. 2003) 2 3 4 23
  3. Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. (PMID: 12490608) Hasbak P. … Edvinsson L. (J. Pharmacol. Exp. Ther. 2003) 3 23
  4. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. (PMID: 10903324) Evans B.N. … Dickerson I.M. (J. Biol. Chem. 2000) 3 23
  5. The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. (PMID: 11754963) Prado M.A. … Dickerson I.M. (Peptides 2001) 3 23

Products for CRCP Gene

Sources for CRCP Gene

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