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Aliases for CRCP Gene

Aliases for CRCP Gene

  • CGRP Receptor Component 2 3 5
  • Calcitonin Gene-Related Peptide-Receptor Component Protein 2 3 4
  • CGRP-Receptor Component Protein 3 4
  • RNA Polymerase III Subunit C9 3 4
  • CGRP-RCP 3 4
  • CGRPRCP 3 4
  • HsC17 4
  • RCP9 3
  • RCP 3

External Ids for CRCP Gene

Previous GeneCards Identifiers for CRCP Gene

  • GC07P065216
  • GC07P065578
  • GC07P061767

Summaries for CRCP Gene

Entrez Gene Summary for CRCP Gene

  • This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRCP Gene

CRCP (CGRP Receptor Component) is a Protein Coding gene. Among its related pathways are Gene Expression and Immune System. GO annotations related to this gene include nucleotide binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot for CRCP Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

  • Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Gene Wiki entry for CRCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCP Gene

Genomics for CRCP Gene

Regulatory Elements for CRCP Gene

Promoters for CRCP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRCP on UCSC Golden Path with GeneCards custom track

Genomic Location for CRCP Gene

Chromosome:
7
Start:
66,114,604 bp from pter
End:
66,154,568 bp from pter
Size:
39,965 bases
Orientation:
Plus strand

Genomic View for CRCP Gene

Genes around CRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCP Gene

Proteins for CRCP Gene

  • Protein details for CRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75575-RPC9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC9
    Protein Accession:
    O75575
    Secondary Accessions:
    • A8MUZ4
    • A8MW23
    • B2R4H4
    • B4E198
    • Q3KRA3
    • Q5HYF1
    • Q8IXL4

    Protein attributes for CRCP Gene

    Size:
    148 amino acids
    Molecular mass:
    16871 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.

    Alternative splice isoforms for CRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRCP Gene

Proteomics data for CRCP Gene at MOPED

Post-translational modifications for CRCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRCP Gene

Domains & Families for CRCP Gene

Protein Domains for CRCP Gene

Graphical View of Domain Structure for InterPro Entry

O75575

UniProtKB/Swiss-Prot:

RPC9_HUMAN :
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
genes like me logo Genes that share domains with CRCP: view

No data available for Gene Families for CRCP Gene

Function for CRCP Gene

Molecular function for CRCP Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
UniProtKB/Swiss-Prot Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Gene Ontology (GO) - Molecular Function for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with CRCP: view
genes like me logo Genes that share phenotypes with CRCP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CRCP

miRNA for CRCP Gene

miRTarBase miRNAs that target CRCP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRCP Gene

Localization for CRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRCP Gene

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRCP Gene COMPARTMENTS Subcellular localization image for CRCP gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0009360 DNA polymerase III complex IDA 12482973
genes like me logo Genes that share ontologies with CRCP: view

Pathways & Interactions for CRCP Gene

genes like me logo Genes that share pathways with CRCP: view

Gene Ontology (GO) - Biological Process for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006383 transcription from RNA polymerase III promoter IDA,TAS 12482973
GO:0007218 neuropeptide signaling pathway IEA --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0044237 cellular metabolic process IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with CRCP: view

No data available for SIGNOR curated interactions for CRCP Gene

Drugs & Compounds for CRCP Gene

(1) Drugs for CRCP Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-3207 HCl Pharma 0

(1) ApexBio Compounds for CRCP Gene

Compound Action Cas Number
MK-3207 HCl 957116-20-0
genes like me logo Genes that share compounds with CRCP: view

Transcripts for CRCP Gene

Unigene Clusters for CRCP Gene

CGRP receptor component:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRCP Gene

No ASD Table

Relevant External Links for CRCP Gene

GeneLoc Exon Structure for
CRCP
ECgene alternative splicing isoforms for
CRCP

Expression for CRCP Gene

mRNA expression in normal human tissues for CRCP Gene

Protein differential expression in normal tissues from HIPED for CRCP Gene

This gene is overexpressed in CD8 Tcells (47.6), Prostate (10.7), and Urinary Bladder (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRCP Gene



SOURCE GeneReport for Unigene cluster for CRCP Gene Hs.300684

mRNA Expression by UniProt/SwissProt for CRCP Gene

O75575-RPC9_HUMAN
Tissue specificity: Ubiquitous. Most prevalent in testis.
genes like me logo Genes that share expression patterns with CRCP: view

Protein tissue co-expression partners for CRCP Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CRCP Gene

Orthologs for CRCP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRCP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRCP 35
  • 88.06 (n)
  • 93.24 (a)
CRCP 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRCP 35
  • 90.02 (n)
  • 93.88 (a)
CRCP 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crcp 35
  • 83.78 (n)
  • 88.51 (a)
Crcp 16
Crcp 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRCP 35
  • 99.77 (n)
  • 100 (a)
CRCP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crcp 35
  • 83.78 (n)
  • 87.16 (a)
oppossum
(Monodelphis domestica)
Mammalia CRCP 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRCP 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRCP 35
  • 78.7 (n)
  • 85.71 (a)
CRCP 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crcp 35
  • 70.15 (n)
  • 78.36 (a)
zebrafish
(Danio rerio)
Actinopterygii crcp 35
  • 68.09 (n)
  • 74.47 (a)
Dr.15889 35
crcp 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007220 35
  • 52.93 (n)
  • 44.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rcp 35
  • 48.23 (n)
  • 36.17 (a)
Rcp 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M106.7 36
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13606 35
Species with no ortholog for CRCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRCP Gene

ENSEMBL:
Gene Tree for CRCP (if available)
TreeFam:
Gene Tree for CRCP (if available)

Paralogs for CRCP Gene

Pseudogenes.org Pseudogenes for CRCP Gene

genes like me logo Genes that share paralogs with CRCP: view

No data available for Paralogs for CRCP Gene

Variants for CRCP Gene

Sequence variations from dbSNP and Humsavar for CRCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs160637 -- 66,119,331(-) aagtg(A/G)tgcac intron-variant
rs160638 -- 66,118,101(-) acttg(G/T)taggc intron-variant
rs160639 -- 66,115,000(+) TTTCG(C/G)CCGAG intron-variant
rs160640 -- 66,114,305(+) cagag(A/G)ttgca upstream-variant-2KB
rs436916 -- 66,129,517(-) GTCTT(A/C)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRCP Gene

Variant ID Type Subtype PubMed ID
esv2664145 CNV Deletion 23128226
nsv511363 CNV Loss 21212237
esv27174 CNV Loss 19812545
nsv511969 CNV Loss 21212237
esv2734594 CNV Deletion 23290073
esv2656542 CNV Deletion 23128226
dgv1113n67 CNV Loss 20364138
esv1751958 CNV Insertion 17803354
esv2674673 CNV Deletion 23128226

Variation tolerance for CRCP Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRCP Gene

HapMap Linkage Disequilibrium report
CRCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRCP Gene

Disorders for CRCP Gene

Relevant External Links for CRCP

Genetic Association Database (GAD)
CRCP
Human Genome Epidemiology (HuGE) Navigator
CRCP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRCP

No disorders were found for CRCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRCP Gene

Publications for CRCP Gene

  1. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PMID: 10067875) Balkan W. … Roos B.A. (Endocrinology 1999) 2 3 4 23 67
  2. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PMID: 12482973) Siaut M. … Conesa C. (Mol. Cell. Biol. 2003) 2 3 23
  3. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. (PMID: 17853344) Goharkhay N. … Wing D.A. (Am J Perinatol 2007) 3 23
  4. Preliminary data suggest that mutations in the CgRP pathway are not involved in human sporadic cryptorchidism. (PMID: 15636430) Zuccarello D. … Dallapiccola B. (J. Endocrinol. Invest. 2004) 3 23
  5. Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. (PMID: 12490608) Hasbak P. … Edvinsson L. (J. Pharmacol. Exp. Ther. 2003) 3 23

Products for CRCP Gene

Sources for CRCP Gene

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