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CRCP Gene

protein-coding   GIFtS: 50
GCID: GC07P065578

CGRP Receptor Component

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CGRP Receptor Component1 2     RNA Polymerase III Subunit C92 3
Calcitonin Gene-Related Peptide-Receptor Component Protein1 2 3     RCP2 5
CGRP-RCP2 3     RCP92
CGRPRCP2 3     DNA-Directed RNA Polymerase III Subunit RPC92
CGRP-Receptor Component Protein2 3     HsC173

External Ids:    HGNC: 178881   Entrez Gene: 272972   Ensembl: ENSG000002412587   OMIM: 6061215   UniProtKB: O755753   

Export aliases for CRCP gene to outside databases

Previous GC identifers: GC07P065216 GC07P061767


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRCP Gene:
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that
increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have
been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for CRCP Gene:
CRCP (CGRP receptor component) is a protein-coding gene. GO annotations related to this gene include calcitonin receptor activity and nucleotide binding.

UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I
interferon and NF- Kappa-B through the RIG-I pathway (By similarity)
Function: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP
responsiveness in a variety of tissues

Gene Wiki entry for CRCP (RCP9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRCP gene promoter:
         FOXF2   FOXO3b   C/EBPalpha   Ik-2   FOXC1   HFH-1   FOXO4   FOXO3a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRCP promoter sequence
   Search Chromatin IP Primers for CRCP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRCP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.1

CRCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRCP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P065578:  view genomic region     (about GC identifiers)

Start:
65,579,591 bp from pter      End:
65,619,555 bp from pter
Size:
39,965 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 64,917,300-64,957,081     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase III subunit RPC9  
Size: 148 amino acids; 16871 Da
Subunit: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity).
Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex
Secondary accessions: A8MUZ4 A8MW23 B2R4H4 B4E198 Q3KRA3 Q5HYF1 Q8IXL4
Alternative splicing: 4 isoforms:  O75575-1   O75575-2   O75575-3   O75575-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRCP: NX_O75575

Explore proteomics data for CRCP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CRCP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035737.1  NP_001035738.1  NP_001135886.1  NP_055293.1  

    ENSEMBL proteins: 
     ENSP00000353589   ENSP00000378736   ENSP00000388653   ENSP00000381674   ENSP00000340044  
     ENSP00000398605  

    CRCP Human Recombinant Protein Products:

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    Novus Biologicals CRCP Proteins
    Novus Biologicals CRCP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CRCP
    Cloud-Clone Corp. Proteins for CRCP

     
    Search eBioscience for Proteins for CRCP 

     
    antibodies-online proteins for CRCP (8 products) 

     
    Search antibodies-online for peptides for CRCP

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    antibodies-online antibodies for CRCP (5 products) 

    CRCP Assay Products:

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    Cloud-Clone Corp. ELISAs for CRCP
    Cloud-Clone Corp. CLIAs for CRCP
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    antibodies-online kits for CRCP (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR010997 HRDC-like
     IPR005574 RNA_pol_II_Rpb4
     IPR006590 RNA_pol_II_Rpb4_core

    Graphical View of Domain Structure for InterPro Entry O75575

    ProtoNet protein and cluster: O75575

    UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
    Similarity: Belongs to the eukaryotic RPC9 RNA polymerase subunit family


    Find genes that share domains with CRCP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPC9_HUMAN, O75575
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs,
    such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA
    viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA
    that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I
    interferon and NF- Kappa-B through the RIG-I pathway (By similarity)
    Function: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP
    responsiveness in a variety of tissues

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001635calcitonin gene-related polypeptide receptor activity IEA--
    GO:0003824catalytic activity ----
    GO:0003899DNA-directed RNA polymerase activity IDA12482973
    GO:0004948calcitonin receptor activity NAS8622957
         
    Find genes that share ontologies with CRCP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CRCP:
     Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRCP

    miRNA
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    Block miRNA regulation of human, mouse, rat CRCP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRCP (see all 15):
    hsa-miR-30c hsa-miR-647 hsa-miR-1266 hsa-miR-30d hsa-miR-551b* hsa-miR-1305 hsa-miR-4261 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCRCP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRCP

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    GenScript: all cDNA clones in your preferred vector (see all 4): CRCP (NM_014478)
    Sino Biological Human cDNA Clone for CRCP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRCP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPC9_HUMAN, O75575: Nucleus (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009360DNA polymerase III complex IDA12482973

    Find genes that share ontologies with CRCP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRCP About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CRCP
        Myometrial Relaxation and Contraction Pathways



        Pathway & Disease-focused RT2 Profiler PCR Array including CRCP: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRCP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRCP (O755753 ENSP000003787364) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCRLQ166023, ENSP000003761774I2D: score=2 STRING: ENSP00000376177
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    POLR3HQ9Y5353, ENSP000003473454I2D: score=1 STRING: ENSP00000347345
    CHRAC1ENSP000002209134STRING: ENSP00000220913
    MAD2L2ENSP000002353104STRING: ENSP00000235310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006383transcription from RNA polymerase III promoter IDA12482973
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0007340acrosome reaction NAS10067875
    GO:0044237cellular metabolic process ----

    Find genes that share ontologies with CRCP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRCP (RPC9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRCP gene (4 alternative transcripts): 
    NM_001040647.1  NM_001040648.1  NM_001142414.1  NM_014478.4  

    Unigene Cluster for CRCP:

    CGRP receptor component
    Hs.300684  [show with all ESTs]
    Unigene Representative Sequence: NR_024548
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360415(uc003tuv.3 uc003tus.3 uc011kdw.2 uc003tut.3 uc003tuu.3)
    ENST00000395326 ENST00000431089 ENST00000398684 ENST00000338592 ENST00000486848
    ENST00000492264 ENST00000415001
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CRCP (see all 15):
    hsa-miR-30c hsa-miR-647 hsa-miR-1266 hsa-miR-30d hsa-miR-551b* hsa-miR-1305 hsa-miR-4261 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCRCP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRCP
    Clone
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    OriGene ORF clones in mouse, rat for CRCP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CRCP (NM_014478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRCP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRCP
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CRCP
      QuantiFast Probe-based Assays in human, mouse, rat CRCP

    Additional mRNA sequence: 

    AF073792.1 AK023295.1 AK290553.1 AK303737.1 AK311829.1 BC040107.1 BC105808.1 NR_024548.1 
    U51134.1 

    19 DOTS entries:

    DT.91692222  DT.101970373  DT.91975813  DT.100706481  DT.121127694  DT.100666867  DT.121127419  DT.40245789 
    DT.75102299  DT.100706480  DT.91745930  DT.100774554  DT.121127589  DT.121127596  DT.91857326  DT.91905208 
    DT.99951320  DT.100774553  DT.99979060 

    Selected AceView cDNA sequences (see all 206):

    NM_014478 CA396260 NM_000048 CR603567 BU621519 BQ064268 BM469369 BI161261 
    BX401300 BI908191 BU844413 CR603715 CA307983 BE563263 BC008195 BM793129 
    AI186427 BE276199 BU634268 BQ062699 AI202801 CR591307 CR618960 CR596097 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRCP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAAACCCC
    CRCP Expression
    About this image

    CRCP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRCP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300684

    UniProtKB/Swiss-Prot: RPC9_HUMAN, O75575
    Tissue specificity: Ubiquitous. Most prevalent in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including CRCP: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRCP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRCP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crcp1 , 5 calcitonin gene-related peptide-receptor component more1, 5 83.78(n)1
    88.51(a)1
      5 (68.42 cM)5
    129091  NM_007761.21  NP_031787.11 
     1300292905 
    chicken
    (Gallus gallus)
    Aves CRCP1 CGRP receptor component 78.7(n)
    85.71(a)
      396022  XM_415793.3  XP_415793.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056658.12   -- 75.53(n)    BC056658.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158892 Transcribed sequence with moderate similarity to protein more 72.5(n)    BM531243.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rcp1 Receptor component protein 48.23(n)
    36.17(a)
      32678  NM_206770.2  NP_996493.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M106.76
    Protein M106.7 (M106.7) mRNA, complete cds
    37(a)
    1 ↔ 1
    II(10855642-10857179) WBGene00044924


    ENSEMBL Gene Tree for CRCP (if available)
    TreeFam Gene Tree for CRCP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRCP gene
    Selected SIMAP similar genes for CRCP using alignment to 3 protein entries:     RPC9_HUMAN (see all proteins) (see all similar genes):
    KDM5B    FAM175A    HOOK2    MPP4    ERBB2    HKR1
    LYRM4    FAM3A    TNFRSF17    WARS    ZNF546    DYM
    TCF4    TMEM44    ZNF738    APOPT1    ZNF611    NEK4

    Find genes that share paralogs with CRCP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CRCP
    PGOHUM00000232838


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRCP (see all 907)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115234121,2
    C,F--65577874(+) GCCCGA/C/GCTCGG 5 -- us2k11WA 2
    rs1828082631,2
    --65577877(+) CGCCTC/TGGCCT 5 -- us2k10--------
    rs126680101,2
    C,H--65578066(+) atgagG/Tgactt 5 -- us2k10--------
    rs1148246451,2
    F--65578167(+) TTGTAT/CTGCCA 5 -- us2k11Minor allele frequency- C:0.04WA 118
    rs567680541,2
    C--65578353(+) TGAGAA/CCCCCA 5 -- us2k10--------
    rs1916118831,2
    --65578487(+) GCTGAG/TGAGGG 5 -- us2k10--------
    rs1837551881,2
    --65578588(+) ATGGCA/GGGCAC 5 -- us2k10--------
    rs2013035581,2
    C--65578731(+) AAAAA-/A/AG  
            
    GAAAA
    5 -- us2k10--------
    rs3138251,2
    C--65578732(+) aaaaaA/Gaaaaa 5 -- us2k12Minor allele frequency- G:0.00NA WA 4
    rs1474058531,2
    C--65578732(+) AAAAA-/GAAAAA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRCP (65579591 - 65619555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CRCP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674673CNV Deletion23128226
    esv2734594CNV Deletion23290073
    esv2656542CNV Deletion23128226
    esv2664145CNV Deletion23128226
    esv1751958CNV Insertion17803354
    dgv1113n67CNV Loss20364138
    nsv511969CNV Loss21212237
    nsv511363CNV Loss21212237
    esv27174CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606121    OMIM disorders: --


    Find genes that share disorders with CRCP           About GenesLikeMe

    Genetic Association Database (GAD): CRCP
    Human Genome Epidemiology (HuGE) Navigator: CRCP (2 documents)

    Export disorders for CRCP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRCP gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CRCP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PubMed id 10067875)1, 2, 3, 9 Balkan W.... Roos B.A. (Endocrinology 1999)
    2. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PubMed id 12482973)1, 2, 3, 9 Siaut M.... Conesa C. (Mol. Cell. Biol. 2003)
    3. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PubMed id 21223598)1, 4 Wineinger N.E....Tiwari H.K. (BMC Med Genomics 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. (PubMed id 12391170)1, 2 Hu P....Hernandez N. (Mol. Cell. Biol. 2002)
    9. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. (PubMed id 8622957)1, 3 Luebke A.E....Dickerson I.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    10. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. (PubMed id 17853344)1, 9 Goharkhay N....Wing D.A. (Am J Perinatol 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27297 HGNC: 17888 AceView: ASLandRCP9 Ensembl:ENSG00000241258 euGenes: HUgn27297
    ECgene: CRCP H-InvDB: CRCP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRCP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRCP gene:
    Search GeneIP for patents involving CRCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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