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Aliases for CRCP Gene

Aliases for CRCP Gene

  • CGRP Receptor Component 2 3 5
  • Calcitonin Gene-Related Peptide-Receptor Component Protein 2 3 4
  • CGRP-Receptor Component Protein 3 4
  • RNA Polymerase III Subunit C9 3 4
  • CGRP-RCP 3 4
  • CGRPRCP 3 4
  • DNA-Directed RNA Polymerase III Subunit RPC9 3
  • HsC17 4
  • RCP9 3
  • RCP 3

External Ids for CRCP Gene

Previous GeneCards Identifiers for CRCP Gene

  • GC07P065216
  • GC07P065578
  • GC07P061767

Summaries for CRCP Gene

Entrez Gene Summary for CRCP Gene

  • This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRCP Gene

CRCP (CGRP Receptor Component) is a Protein Coding gene. Among its related pathways are Innate Immune System and RNA Polymerase III Transcription Initiation. GO annotations related to this gene include nucleotide binding and RNA polymerase III activity.

UniProtKB/Swiss-Prot for CRCP Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).

  • Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Gene Wiki entry for CRCP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRCP Gene

Genomics for CRCP Gene

Regulatory Elements for CRCP Gene

Enhancers for CRCP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G066281 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +168.3 168300 3.3 FOXA2 ZSCAN4 SIN3A ZBTB40 RAD21 YY1 RARA ZNF121 ZNF766 FOS LOC100996437 GS1-124K5.4 CRCP TPST1 RABGEF1 KCTD7 GC07P066239 GC07P066346 RNU6-313P
GH07G066653 1.7 FANTOM5 ENCODE dbSUPER 17.4 +540.4 540351 3.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B LOC100996437 ENSG00000229180 RABGEF1 VKORC1L1 GS1-124K5.4 CRCP KCTD7 TYW1 ENSG00000244657 LOC100420547
GH07G066589 1.4 Ensembl ENCODE 19.8 +477.1 477126 3.9 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 LOC100996437 VKORC1L1 ENSG00000229180 CRCP RABGEF1 KCTD7 CCT6P1 ENSG00000177418
GH07G066757 1.4 FANTOM5 Ensembl ENCODE 16.9 +644.4 644397 2.4 CTCF MAX YY1 ZNF316 HNF4G ETV6 MAFK HOMEZ CREM HLF LOC100996437 RABGEF1 ENSG00000229180 GS1-124K5.4 CRCP KCTD7 ENSG00000271064 GC07M066788
GH07G066254 1.1 Ensembl ENCODE dbSUPER 18.4 +141.0 140985 2.0 MAFF ZNF316 MAFG CEBPB EP300 EMSY MAFK LOC100996437 VKORC1L1 CRCP GC07P066239 GC07P066346 RNU6-313P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CRCP on UCSC Golden Path with GeneCards custom track

Promoters for CRCP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212914 396 1601 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for CRCP Gene

Chromosome:
7
Start:
66,114,604 bp from pter
End:
66,154,568 bp from pter
Size:
39,965 bases
Orientation:
Plus strand

Genomic View for CRCP Gene

Genes around CRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRCP Gene

Proteins for CRCP Gene

  • Protein details for CRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75575-RPC9_HUMAN
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC9
    Protein Accession:
    O75575
    Secondary Accessions:
    • A8MUZ4
    • A8MW23
    • B2R4H4
    • B4E198
    • Q3KRA3
    • Q5HYF1
    • Q8IXL4

    Protein attributes for CRCP Gene

    Size:
    148 amino acids
    Molecular mass:
    16871 Da
    Quaternary structure:
    • Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). Interacts with POLR3H/RPC8. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.

    Alternative splice isoforms for CRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRCP Gene

Post-translational modifications for CRCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CRCP Gene

Domains & Families for CRCP Gene

Protein Domains for CRCP Gene

Graphical View of Domain Structure for InterPro Entry

O75575

UniProtKB/Swiss-Prot:

RPC9_HUMAN :
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
Family:
  • Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
genes like me logo Genes that share domains with CRCP: view

No data available for Gene Families for CRCP Gene

Function for CRCP Gene

Molecular function for CRCP Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
UniProtKB/Swiss-Prot Function:
Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Gene Ontology (GO) - Molecular Function for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001056 contributes_to RNA polymerase III activity IBA --
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0003824 catalytic activity IEA --
GO:0003899 DNA-directed 5-3 RNA polymerase activity IDA 12482973
genes like me logo Genes that share ontologies with CRCP: view
genes like me logo Genes that share phenotypes with CRCP: view

Animal Model Products

CRISPR Products

miRNA for CRCP Gene

miRTarBase miRNAs that target CRCP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRCP Gene

Localization for CRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRCP Gene

Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRCP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005666 DNA-directed RNA polymerase III complex IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CRCP: view

Pathways & Interactions for CRCP Gene

genes like me logo Genes that share pathways with CRCP: view

Gene Ontology (GO) - Biological Process for CRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter IDA 12482973
GO:0006384 transcription initiation from RNA polymerase III promoter IBA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with CRCP: view

No data available for SIGNOR curated interactions for CRCP Gene

Drugs & Compounds for CRCP Gene

(1) Drugs for CRCP Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-3207 HCl Pharma 0 0

(1) ApexBio Compounds for CRCP Gene

Compound Action Cas Number
MK-3207 HCl 0 957116-20-0
genes like me logo Genes that share compounds with CRCP: view

Drug Products

Transcripts for CRCP Gene

Unigene Clusters for CRCP Gene

CGRP receptor component:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRCP Gene

No ASD Table

Relevant External Links for CRCP Gene

GeneLoc Exon Structure for
CRCP
ECgene alternative splicing isoforms for
CRCP

Expression for CRCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRCP Gene

Protein differential expression in normal tissues from HIPED for CRCP Gene

This gene is overexpressed in CD8 Tcells (47.6), Prostate (10.7), and Urinary Bladder (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CRCP Gene



Protein tissue co-expression partners for CRCP Gene

NURSA nuclear receptor signaling pathways regulating expression of CRCP Gene:

CRCP

SOURCE GeneReport for Unigene cluster for CRCP Gene:

Hs.300684

mRNA Expression by UniProt/SwissProt for CRCP Gene:

O75575-RPC9_HUMAN
Tissue specificity: Ubiquitous. Most prevalent in testis.

Evidence on tissue expression from TISSUES for CRCP Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Adrenal gland(4.2)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with CRCP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRCP Gene

Orthologs for CRCP Gene

This gene was present in the common ancestor of animals.

Orthologs for CRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRCP 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia CRCP 34 35
  • 90.02 (n)
cow
(Bos Taurus)
Mammalia CRCP 34 35
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Crcp 34 16 35
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Crcp 34
  • 83.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRCP 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRCP 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRCP 34 35
  • 78.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia crcp 34
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii crcp 34 35
  • 68.09 (n)
Dr.15889 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007220 34
  • 52.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rcp 34 35
  • 48.23 (n)
worm
(Caenorhabditis elegans)
Secernentea M106.7 35
  • 37 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13606 34
Species where no ortholog for CRCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRCP Gene

ENSEMBL:
Gene Tree for CRCP (if available)
TreeFam:
Gene Tree for CRCP (if available)

Paralogs for CRCP Gene

Pseudogenes.org Pseudogenes for CRCP Gene

genes like me logo Genes that share paralogs with CRCP: view

No data available for Paralogs for CRCP Gene

Variants for CRCP Gene

Sequence variations from dbSNP and Humsavar for CRCP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000034769 -- 66,141,518(+) AGAGG(A/G)TGAAA intron-variant
rs1000148937 -- 66,141,762(+) TGATC(A/G)CTTGG intron-variant
rs1000259510 -- 66,135,299(+) GCTAA(C/T)CAAAG intron-variant
rs1000321287 -- 66,118,692(+) TCATC(C/T)CTAGA intron-variant
rs1000534551 -- 66,149,807(+) CCCCC(A/G)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRCP Gene

Variant ID Type Subtype PubMed ID
dgv1113n67 CNV loss 20364138
dgv11431n54 CNV loss 21841781
dgv11432n54 CNV loss 21841781
dgv11433n54 CNV loss 21841781
esv1751958 CNV insertion 17803354
esv2656542 CNV deletion 23128226
esv2664145 CNV deletion 23128226
esv2674673 CNV deletion 23128226
esv27174 CNV loss 19812545
esv2761079 CNV gain+loss 21179565
esv3541796 CNV deletion 23714750
esv3571888 CNV loss 25503493
esv3613500 CNV loss 21293372
esv3613502 CNV loss 21293372
nsv1021186 CNV gain 25217958
nsv511363 CNV loss 21212237
nsv511969 CNV loss 21212237
nsv607396 CNV loss 21841781
nsv607400 CNV loss 21841781
nsv607414 CNV loss 21841781

Variation tolerance for CRCP Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRCP Gene

Disorders for CRCP Gene

Relevant External Links for CRCP

Genetic Association Database (GAD)
CRCP
Human Genome Epidemiology (HuGE) Navigator
CRCP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRCP

No disorders were found for CRCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRCP Gene

Publications for CRCP Gene

  1. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP. (PMID: 12482973) Siaut M. … Conesa C. (Mol. Cell. Biol. 2003) 2 3 4 22 64
  2. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. (PMID: 10067875) Balkan W. … Roos B.A. (Endocrinology 1999) 2 3 4 22 64
  3. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PMID: 21223598) Wineinger N.E. … Tiwari H.K. (BMC Med Genomics 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. (PMID: 17853344) Goharkhay N. … Wing D.A. (Am J Perinatol 2007) 3 22 64

Products for CRCP Gene

Sources for CRCP Gene

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