CRBN Gene
protein-coding GIFtS: 48
GCID: GC03M003166
|
|
cereblon(Previous names: mental retardation, non-syndromic, autosomal recessive,...)
(Previous symbol: MRT2A)
| |
Aliases
for CRBN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cereblon1 | | MRT2A1 2 5 | | Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A1 | | MRT22 | | Protein Cereblon2 | | Protein X 00012 |
Export aliases for CRBN gene to outside databases |
Summaries
for CRBN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CRBN:
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene productis found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in braindevelopment. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multipletranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitinationand subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of thefibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronalsurface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory andlearning via its interaction with KCNT1
Gene Wiki entry for CRBN (Cereblon)
|
Genomic Views
for CRBN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRBN gene promoter:
GR USF1 Pbx1a GR-beta Lmo2 CUTL1 HEN1 USF-1 GR-alpha Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRBN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRBN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p26.2 Ensembl cytogenetic band: 3p26.2 HGNC cytogenetic band: 3p26.3CRBN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M003166: view genomic region
(about GC identifiers)
Start:
|
3,190,676 bp from pter |
End:
|
3,221,401 bp from pter |
Size:
|
30,726 bases |
Orientation:
|
minus strand |
|
Proteins
for CRBN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2 (See
protein sequence)Recommended Name: Protein cereblon Size: 442 amino acids; 50546 Da
Subunit: Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at leastcomposed of CRBN, CUL4A, DDB1 and RBX1
Subcellular location: Cytoplasm. Nucleus. Membrane; Peripheral membrane protein (By similarity)
Miscellaneous: Specifically binds thalidomide, a drug widely prescribed to pregnant women in the late 1950s.Thalidomide was sold as a sedative but was found to be teratogenic, causing multiple birth defects. Recently,thalidomide use has increased for the treatment of multiple myeloma and erythema nodosum leprosum, a painfulcomplication of leprosy. Thalidomide teratogenic activity may be a consequence of CRBN-binding, which inhibits theubiquitin ligase activity of the DCX (DDB1-CUL4-X-box) protein ligase complex, possibly leading to abnormal regulationof the BMP and FGF8 signaling pathways (PubMed:20223979)
Caution: Although it contains a Lon domain also found in proteases of the peptidase S16 family, it does not contain theATP-binding and catalytic domains, suggesting that it has no protease activity
Sequence caution: Sequence=AAF17211.1; Type=Frameshift; Positions=347, 397, 401; Sequence=BAG35471.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=BAG35471.1; Type=Frameshift; Positions=347;
Secondary accessions: B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4Alternative splicing: 2 isoforms: Q96SW2-1 Q96SW2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CRBN: NX_Q96SW2
Post-translational modifications:
Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SW2
CRBN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001166953.1 NP_057386.2
ENSEMBL proteins: ENSP00000411047 ENSP00000231948 ENSP00000412499 ENSP00000392073
Human Recombinant Protein Products for CRBN:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CRBN for ontologies About GeneDecksing
CRBN Antibody Products:
Assay Products for CRBN: |
Protein
Domains /
Families
for CRBN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRBN for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SW2ProtoNet protein and cluster: Q96SW2 UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2Similarity: Belongs to the CRBN familySimilarity: Contains 1 Lon domain |
Function
for CRBN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CRBN_HUMAN, Q96SW2Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitinationand subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of thefibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronalsurface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory andlearning via its interaction with KCNT1 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004176 | ATP-dependent peptidase activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
CRBN for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Crbn):
CRBN for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Crbntm1.2Jjh for CRBN
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CRBN (NM_016302) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRBN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRBN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRBN |
|
Pathways & Interactions
for CRBN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRBN
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/28 Interacting proteins for CRBN (Q96SW23 ENSP000002319484) via UniProtKB, MINT, STRING, and/or I2D (see all 28) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
-- | -- | | GO:0016567 | protein ubiquitination |
IMP | -- | | GO:0032463 | negative regulation of protein homooligomerization |
IEA | -- | | GO:0034766 | negative regulation of ion transmembrane transport |
IEA | -- | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
IMP | -- |
CRBN for ontologies About GeneDecksing
|
Drugs & Compounds
for CRBN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CRBN
Search CenterWatch for drugs/clinical trials and news about CRBN
|
Transcripts
for CRBN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRBN gene (2 alternative transcripts): NM_001173482.1 NM_016302.3 Unigene Cluster for CRBN: Cereblon Hs.18925 [show with all ESTs]Unigene Representative Sequence: CR62706013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491834(uc003bpr.3 uc003bpq.3) ENST00000488263 ENST00000424814
ENST00000231948 ENST00000432408(uc011aso.2) ENST00000459840 ENST00000498442
ENST00000482844 ENST00000480249 ENST00000450014 ENST00000498700 ENST00000492178
ENST00000478353
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CRBN (NM_016302) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRBN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRBN |
Additional cDNA sequence: AF117230.1 AK027507.1 AK058191.1 AK301423.1 AK312577.1 BC017419.1 BC059171.1 BC067811.1 CR627060.1 24/27 DOTS entries (see all 27): DT.452330 DT.100823733 DT.95206562 DT.99989521 DT.40275437 DT.120894843 DT.91752483 DT.120894790 DT.100823727 DT.120894846 DT.95359149 DT.91752480 DT.100823728 DT.120894816 DT.100823730 DT.120894838 DT.318120 DT.100823723 DT.100823734 DT.120894786 DT.120894854 DT.92042848 DT.99975413 DT.120894865 24/308 AceView cDNA sequences (see all 308): AA515699 BM828801 CB132326 AI038380 NM_016302 CA407464 AA251223 AA731110 AA446969 AI638828 CR608669 AU279936 AL560737 CA423261 CR617747 AA476649 BM975094 AA767340 AW450410 AA251109 BG428916 AI193355 BQ231978 AL705524
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CRBN (see all 15) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | | | - | | - | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CRBN
|
Expression
for CRBN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRBN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGACATCTT
About this image
See CRBN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRBN
SOURCE GeneReport for Unigene cluster: Hs.18925
UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2Tissue specificity: Widely expressed. Highly expressed in brain
SABiosciences Expression via Pathway-Focused PCR Array including CRBN:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRBN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRBN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRBN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRBN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRBN |
Orthologs
for CRBN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CRBN gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for CRBN (if available)
TreeFam Gene Tree for CRBN (if available) |
Paralogs
for CRBN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRBN gene
CRBN for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CRBN
PGOHUM00000250227 PGOHUM00000232975
|
Genomic Variants
for CRBN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRBN (3190676 - 3221401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CRBN
3 CNVs: 8407 5211 36142
Human Gene Mutation Database (HGMD): CRBN
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRBN |
|
Disorders
/ Diseases
for CRBN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRBN for disorders About GeneDecksing
OMIM gene information: 609262
OMIM disorders: 607417
UniProtKB/Swiss-Prot: CRBN_HUMAN, Q96SW2
Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A) [MIM:607417]. MRT2Apatients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males thanfemales. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromicmental retardation patients do not manifest other clinical signs
7  diseases for CRBN: About MalaCardsmental retardation, autosomal recessive 2a birth defects intellectual disability multiple myeloma
leprosy myeloma neuronitis
1 disease from the University of Copenhagen DISEASES database for CRBN:Intellectual disability Export disorders for CRBN gene to outside databases
|
Publications
for CRBN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRBN gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with CRBN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. (PubMed id 15557513)1, 2, 3, 9 Higgins J.J.... Rooney J.P. (2004)
- Primary function analysis of human mental retardation related gene CRBN. (PubMed id 17380424)1, 2, 9 Xin W.... Qihan W. (2008)
- Identification of a primary target of thalidomide teratogenicity. (PubMed id 20223979)1, 2 Ito T.... Handa H. (2010)
- Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. (PubMed id 18414909)1, 2 Higgins J.J.... Rajadhyaksha A.M. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Temporal and spatial mouse brain expression of cerebl on, an ionic channel regulator involved in human intelligence. (PubMed id 20131966)1, 9 Higgins J.J....Rajadhyaksha A.M. (2010)
- Cereblon inhibits proteasome activity by binding to th e 20S core proteasome subunit beta type 4. (PubMed id 23026050)1 Lee K.M....Park C.S. (2012)
- Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (2012)
|
External Searches for CRBN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CRBN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRBN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRBN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CRBN | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt117.shtml |
|
| | |
About This Section
| Patent Information for CRBN gene:
Search GeneIP for patents involving CRBN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRBN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CRBN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRBN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRBN | | | OriGene Protein Over-expression Lysate for CRBN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CRBN | | OriGene 3'-UTR Clone for CRBN | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRBN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CRBN | | OriGene Custom Protein Services for CRBN | | | OriGene Custom Immunoassay Development | | |
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