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Aliases for CRB3 Gene

Aliases for CRB3 Gene

  • Crumbs Family Member 3 2 3
  • Crumbs Homolog 3 (Drosophila) 2

External Ids for CRB3 Gene

Summaries for CRB3 Gene

Entrez Gene Summary for CRB3 Gene

  • This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRB3 Gene

CRB3 (Crumbs Family Member 3) is a Protein Coding gene. Diseases associated with CRB3 include leber congenital amaurosis. Among its related pathways are Cell junction organization and Cell junction organization. GO annotations related to this gene include protein domain specific binding and SH3 domain binding.

UniProtKB/Swiss-Prot for CRB3 Gene

  • Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.

Gene Wiki entry for CRB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRB3 Gene

Genomics for CRB3 Gene

Genomic Location for CRB3 Gene

6,463,777 bp from pter
6,467,221 bp from pter
3,445 bases
Plus strand

Genomic View for CRB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRB3 Gene

Regulatory Elements for CRB3 Gene

Proteins for CRB3 Gene

  • Protein details for CRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein crumbs homolog 3
    Protein Accession:
    Secondary Accessions:
    • A8KA91
    • D6W643
    • Q8N0V8
    • Q8WVA0

    Protein attributes for CRB3 Gene

    120 amino acids
    Molecular mass:
    12854 Da
    Quaternary structure:
    • Interacts with MPP5, PARD6A and INADL.

    Alternative splice isoforms for CRB3 Gene


neXtProt entry for CRB3 Gene

Proteomics data for CRB3 Gene at MOPED

Post-translational modifications for CRB3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn36

Other Protein References for CRB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CRB3 Gene

Domains for CRB3 Gene

Protein Domains for CRB3 Gene



  • The PDZ-binding motif is involved in the interactions with PARD6A and MPP5:
    • Q9BUF7
genes like me logo Genes that share domains with CRB3: view

No data available for Gene Families for CRB3 Gene

Function for CRB3 Gene

Molecular function for CRB3 Gene

UniProtKB/Swiss-Prot Function: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.

Gene Ontology (GO) - Molecular Function for CRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0017124 SH3 domain binding IPI 17332497
GO:0019904 protein domain specific binding IPI 17332497
genes like me logo Genes that share ontologies with CRB3: view

miRNA for CRB3 Gene

miRTarBase miRNAs that target CRB3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CRB3 Gene

Localization for CRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRB3 Gene

Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.

Subcellular locations from

Jensen Localization Image for CRB3 Gene COMPARTMENTS Subcellular localization image for CRB3 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with CRB3: view

Pathways for CRB3 Gene

genes like me logo Genes that share pathways with CRB3: view

Pathways by source for CRB3 Gene

1 KEGG pathway for CRB3 Gene

Gene Ontology (GO) - Biological Process for CRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034329 cell junction assembly TAS --
GO:0045216 cell-cell junction organization TAS --
GO:0070830 bicellular tight junction assembly TAS --
GO:0072659 protein localization to plasma membrane IDA 17332497
genes like me logo Genes that share ontologies with CRB3: view

Transcripts for CRB3 Gene

Unigene Clusters for CRB3 Gene

Crumbs homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRB3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3: -

Relevant External Links for CRB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRB3 Gene

mRNA expression in normal human tissues for CRB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRB3 Gene

This gene is overexpressed in Esophagus - Mucosa (6.2), Pancreas (5.2), and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CRB3 Gene

SOURCE GeneReport for Unigene cluster for CRB3 Gene Hs.150319

mRNA Expression by UniProt/SwissProt for CRB3 Gene

Tissue specificity: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
genes like me logo Genes that share expressions with CRB3: view

Orthologs for CRB3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CRB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRB3 37
  • 98 (a)
(Mus musculus)
Mammalia Crb3 16
Crb3 37
  • 56 (a)
Species with no ortholog for CRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRB3 Gene

Gene Tree for CRB3 (if available)
Gene Tree for CRB3 (if available)

Paralogs for CRB3 Gene

Selected SIMAP similar genes for CRB3 Gene using alignment to 1 proteins: Pseudogenes for CRB3 Gene

genes like me logo Genes that share paralogs with CRB3: view

No data available for Paralogs for CRB3 Gene

Variants for CRB3 Gene

Sequence variations from dbSNP and Humsavar for CRB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs168349 -- 6,463,126(+) tgcaa(C/T)ctctg upstream-variant-2KB
rs184927 -- 6,462,653(+) ATGAT(A/G)ATGCA upstream-variant-2KB
rs348359 -- 6,464,925(+) GAGGG(G/T)TCTAC intron-variant
rs348360 -- 6,465,342(+) TGGGT(C/G)GGGGG intron-variant
rs348361 -- 6,466,115(+) GGAAT(C/T)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRB3 Gene

Variant ID Type Subtype PubMed ID
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
nsv833727 CNV Loss 17160897
nsv910923 CNV Loss 21882294
nsv910924 CNV Loss 21882294

Relevant External Links for CRB3 Gene

HapMap Linkage Disequilibrium report

Disorders for CRB3 Gene

(1) University of Copenhagen DISEASES for CRB3 Gene

genes like me logo Genes that share disorders with CRB3: view

No data available for UniProtKB/Swiss-Prot for CRB3 Gene

Publications for CRB3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). (PMID: 12527193) Makarova O. … Margolis B. (Gene 2003) 3 4
  3. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. (PMID: 12771187) Roh M.H. … Margolis B. (J. Cell Sci. 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. (PMID: 14718572) Lemmers C. … Le Bivic A. (Mol. Biol. Cell 2004) 3 4

Products for CRB3 Gene

Sources for CRB3 Gene

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