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CRB3 Gene

protein-coding   GIFtS: 53
GCID: GC19P006463

Crumbs Family Member 3

(Previous name: crumbs homolog 3 (Drosophila))
  See CRB3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crumbs Family Member 31 2
Crumbs Homolog 3 (Drosophila)1
Crumbs Homolog 32
Crumbs Protein Homolog 32
Protein Crumbs Homolog 32

External Ids:    HGNC: 202371   Entrez Gene: 923592   Ensembl: ENSG000001305457   OMIM: 6097375   UniProtKB: Q9BUF73   

Export aliases for CRB3 gene to outside databases

Previous GC identifers: GC19P006558 GC19P006403 GC19P006414 GC19P006228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRB3 Gene:
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell
polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul
2008)

GeneCards Summary for CRB3 Gene:
CRB3 (crumbs family member 3) is a protein-coding gene. Diseases associated with CRB3 include leber congenital amaurosis. GO annotations related to this gene include SH3 domain binding and protein domain specific binding.

UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
Function: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the
morphogenesis of tight junctions

Gene Wiki entry for CRB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRB3 gene promoter:
         MAZR   Pax-5   AML1a   MIF-1   LUN-1   Nkx2-5   LCR-F1   E47   Roaz   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRB3 promoter sequence
   Search Chromatin IP Primers for CRB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006463:  view genomic region     (about GC identifiers)

Start:
6,463,788 bp from pter      End:
6,467,232 bp from pter
Size:
3,445 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7 (See protein sequence)
Recommended Name: Protein crumbs homolog 3 precursor  
Size: 120 amino acids; 12854 Da
Subunit: Interacts with MPP5, PARD6A and INADL
Secondary accessions: A8KA91 D6W643 Q8N0V8 Q8WVA0
Alternative splicing: 2 isoforms:  Q9BUF7-1   Q9BUF7-2   

Explore the universe of human proteins at neXtProt for CRB3: NX_Q9BUF7

Explore proteomics data for CRB3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36
  • Modification sites at PhosphoSitePlus

  • See CRB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_631900.1  NP_777377.1  

    ENSEMBL proteins: 
     ENSP00000469707   ENSP00000472010   ENSP00000349204   ENSP00000310123  
    Reactome Protein details: Q9BUF7

    CRB3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9BUF7

    UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
    Domain: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRUM3_HUMAN, Q9BUF7
    Function: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the
    morphogenesis of tight junctions

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017124SH3 domain binding IPI17332497
    GO:0019904protein domain specific binding IPI17332497
         
    Find genes that share ontologies with CRB3           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Crb3 (no phenotypes)

    Find genes that share phenotypes with CRB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Crb3tm1Lex for CRB3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CRB3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CRB3

    miRNA
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    miRTarBase miRNAs that target CRB3:
    hsa-mir-335-5p (MIRT017389)

    Block miRNA regulation of human, mouse, rat CRB3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CRB3:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidCRB3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CRB3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRUM3_HUMAN, Q9BUF7: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
    Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of
    epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IEA--
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with CRB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRB3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Tight junction interactions0.51
    2Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    3Tight junction
    Tight junction


    Find genes that share SuperPaths with CRB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CRB3
        Epithelial Tight Junctions


    1 Reactome Pathway for CRB3
        Tight junction interactions


    1 Kegg Pathway  (Kegg details for CRB3):
        Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Array including CRB3: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CRB3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRB3 (Q9BUF73 ENSP000003492044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP5Q8N3R93, ENSP000002616814I2D: score=1 STRING: ENSP00000261681
    PARD6AQ9NPB63, ENSP000002192554I2D: score=1 STRING: ENSP00000219255
    INADLENSP000003602004STRING: ENSP00000360200
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--
    GO:0072659protein localization to plasma membrane IDA17332497

    Find genes that share ontologies with CRB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRB3 (CRUM3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRB3 gene (2 alternative transcripts): 
    NM_139161.3  NM_174881.2  

    Unigene Cluster for CRB3:

    Crumbs homolog 3 (Drosophila)
    Hs.150319  [show with all ESTs]
    Unigene Representative Sequence: AY103469
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598494 ENST00000600229 ENST00000356762(uc002mey.3 uc002mez.3 uc002mfa.3)
    ENST00000308243
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CRB3:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidCRB3 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CRB3
      QuantiTect SYBR Green Assays in human, mouse, rat CRB3
      QuantiFast Probe-based Assays in human, mouse, rat CRB3

    Additional mRNA sequence: 

    AF503290.1 AK000653.1 AK292956.1 AY103469.1 AY358684.1 BC002652.2 BC018409.1 

    4 DOTS entries:

    DT.404203  DT.97811647  DT.100021817  DT.97824364 

    Selected AceView cDNA sequences (see all 76):

    NM_174881 BM052788 BQ017203 BM998983 AW300987 BQ012165 BM773470 BX107331 
    BM769084 AF503290 BM126963 BC002652 BM818275 AW205946 NM_174882 BM273031 
    BE531149 BU677706 CK903996 NM_139161 AY103469 BI966036 AI911820 BI966223 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRB3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:                    -                       -     -               
    SP2:        -     -     -                                             
    SP3:                    -                                             
    SP4:                                                                  


    ECgene alternative splicing isoforms for CRB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCGAGGC
    CRB3 Expression
    About this image


    CRB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Pancreas (Endocrine System)
    CRB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150319

    UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
    Tissue specificity: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney,
    retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including CRB3: 
              Tight Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CRB3 gene from Selected species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crb35 crumbs homolog 3 (Drosophila)   --   17 (29.65 cM) 57059105 


    ENSEMBL Gene Tree for CRB3 (if available)
    TreeFam Gene Tree for CRB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRB3 gene
    1 SIMAP similar gene for CRB3 using alignment to 1 protein entry:     CRUM3_HUMAN:
    CRB2

    Find genes that share paralogs with CRB3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CRB3
    PGOHUM00000237519


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRB3 (see all 128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467912921,2
    --6387266(+) GTTCCC/TCCTAC 2 -- us2k10--------
    rs1896691491,2
    --6387455(+) GGTATG/TTACAA 2 -- us2k10--------
    rs1849271,2
    C,F--6387585(+) ATGATA/GATGCA 2 -- us2k14Minor allele frequency- G:0.01MN NA WA 190
    rs1811475161,2
    --6387700(+) AGTGGC/TGTGAT 2 -- us2k10--------
    rs1862861871,2
    --6387784(+) ACAGGC/TGCCCA 2 -- us2k10--------
    rs1865677151,2
    --6387863(+) GGTCTC/GGAACT 2 -- us2k10--------
    rs1456949921,2
    C--6387864(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1382481811,2
    --6387870(+) AACTCA/GTGACC 2 -- us2k10--------
    rs1683491,2
    C,F,A,H--6388060(+) tgcaaT/Cctctg 2 -- us2k1 tfbs38Minor allele frequency- C:0.44NA WA CSA 16
    rs1433656031,2
    C--6388106(+) CCCCCA/GAGTAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRB3 (6463788 - 6467232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CRB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910916CNV Loss21882294
    nsv910924CNV Loss21882294
    nsv910923CNV Loss21882294
    nsv833727CNV Loss17160897
    dgv3698n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRB3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609737    OMIM disorders: --

    1 disease for CRB3:    
    About MalaCards
    leber congenital amaurosis

    1 disease from the University of Copenhagen DISEASES database for CRB3:
    Leber congenital amaurosis

    Find genes that share disorders with CRB3           About GenesLikeMe


    Export disorders for CRB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRB3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CRB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. (PubMed id 14718572)1, 2 Lemmers C.... Le Bivic A. (Mol. Biol. Cell 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). (PubMed id 12527193)1, 2 Makarova O.... Margolis B. (Gene 2003)
    4. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. (PubMed id 12771187)1, 2 Roh M.H.... Margolis B. (J. Cell Sci. 2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. (PubMed id 17646395)1, 9 Fan S....Margolis B. (J. Cell Biol. 2007)
    7. The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells. (PubMed id 23439680)1 Hayase J....Sumimoto H. (J. Cell Biol. 2013)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. (PubMed id 17988153)1 Pardossi-Piquard R....Fraser P.E. (Biochemistry 2007)
    10. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. (PubMed id 17332497)1 Stucke V.M.... Hall A. (Mol. Biol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92359 HGNC: 20237 AceView: CRB3 Ensembl:ENSG00000130545 euGenes: HUgn92359
    ECgene: CRB3 Kegg: 92359 H-InvDB: CRB3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRB3 Pharmacogenomics, SNPs, Pathways

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