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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRB3 Gene

protein-coding   GIFtS: 51
GCID: GC19P006414

crumbs homolog 3 (Drosophila)
 Explore 2 diseases affiliated with
CRB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CRB3    

Aliases
for CRB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Crumbs Homolog 3 (Drosophila)1 2
MGC173031
Crumbs Protein Homolog 32

External Ids:    HGNC: 202371   Entrez Gene: 923592   Ensembl: ENSG000001305457   OMIM: 6097375   UniProtKB: Q9BUF73   

Export aliases for CRB3 gene to outside databases

Previous GC identifers: GC19P006558 GC19P006403 GC19P006228


Summaries
for CRB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CRB3:
This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity
and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice
variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
Function: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of
tight junctions

Gene Wiki entry for CRB3


Genomic Views
for CRB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRB3 gene promoter:
         MAZR   Pax-5   AML1a   MIF-1   LUN-1   Nkx2-5   LCR-F1   E47   Roaz   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CRB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006414:  view genomic region     (about GC identifiers)

Start:
 6,464,260 bp from pter      End:
 6,467,232 bp from pter
Size:
 2,973 bases      Orientation:
 plus strand

Proteins
for CRB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7 (See protein sequence)
Recommended Name: Protein crumbs homolog 3 precursor  
Size: 120 amino acids; 12854 Da
Subunit: Interacts with MPP5, PARD6A and INADL
Subcellular location: Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of
epithelial cells
Secondary accessions: A8KA91 D6W643 Q8N0V8 Q8WVA0
Alternative splicing: 2 isoforms:  Q9BUF7-1   Q9BUF7-2   

Explore the universe of human proteins at neXtProt for CRB3: NX_Q9BUF7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUF7

    • CRB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_631900.1  NP_777377.1  

    ENSEMBL proteins: 
     ENSP00000349204   ENSP00000310123  
    Reactome Protein details: Q9BUF7
    Human Recombinant Protein Products: 
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    Novus Biologicals CRB3 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CRB3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005923tight junction IEA--
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--


    CRB3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CRB3

    Protein Domains /
    Families
    for CRB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9BUF7

    UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
    Domain: The PDZ-binding motif is involved in the interactions with PARD6A and MPP5


    Function
    for CRB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
    Function: Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of
    tight junctions

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRB3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRB3:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmid: CRB3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CRB3
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CRB3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017124SH3 domain binding IPI17332497
    GO:0019904protein domain specific binding IPI17332497


    CRB3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Crb3tm1Lex for CRB3
         1 MGI phenotypic allele for Crb3 (no phenotypes)

    CRB3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CRB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Tight junction interactions0.49
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Tight junction
    		Tight junction1.00
    3Sertoli-Sertoli Cell Junction Dynamics
    		Epithelial Tight Junctions0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRB3
        Epithelial Tight Junctions

    4        Reactome Pathways for CRB3
        Tight junction interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    1         Kegg Pathway  (Kegg details for CRB3):
        Tight junction


    CRB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRB3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CRB3 (Q9BUF73 ENSP000003492044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPP5Q8N3R93, ENSP000002616814I2D: score=1 STRING: ENSP00000261681
    PARD6AQ9NPB63, ENSP000002192554I2D: score=1 STRING: ENSP00000219255
    INADLENSP000003602004STRING: ENSP00000360200
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization TAS--
    GO:0070830tight junction assembly TAS--
    GO:0072659protein localization to plasma membrane IDA17332497


    CRB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CRB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRB3
    Search CenterWatch for drugs/clinical trials and news about CRB3 / CRUM3 

    Transcripts
    for CRB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CRB3 gene (2 alternative transcripts): 
    NM_139161.3  NM_174881.2  

    Unigene Cluster for CRB3:

    Crumbs homolog 3 (Drosophila)
    Hs.150319  [show with all ESTs]
    Unigene Representative Sequence: AY103469
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356762(uc002mey.3 uc002mez.3 uc002mfa.3) ENST00000308243


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRB3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CRB3:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmid: CRB3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRB3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRB3

    Additional cDNA sequence: 

    AF503290.1 AK000653.1 AK292956.1 AY103469.1 AY358684.1 BC002652.2 BC018409.1 

    4 DOTS entries:

    DT.404203  DT.97811647  DT.100021817  DT.97824364 

    24/76 AceView cDNA sequences (see all 76):

    CB305882 BM052788 BM893793 AI824888 BI966036 CK903996 BI966223 AY103469 
    NM_139161 BU677706 BM126963 NM_174882 BM273031 BC002652 AF503290 AW300987 
    NM_174881 BM998983 BX107331 BM769084 BQ017203 AI911820 BM818275 BM773470 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CRB3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:                    -                       -     -               
    SP2:        -     -     -                                             
    SP3:                    -                                             
    SP4:                                                                  


    ECgene alternative splicing isoforms for CRB3

    Expression
    for CRB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGCCGAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CRB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See CRB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRB3

    SOURCE GeneReport for Unigene cluster: Hs.150319

    UniProtKB/Swiss-Prot: CRUM3_HUMAN, Q9BUF7
    Tissue specificity: Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina,
    colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including CRB3: 
              Tight Junctions in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CRB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CRB3 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Crb31 , 5 crumbs homolog 3 (Drosophila)1, 5 69.03(n)1
    67.26(a)1    		   17 (29.65 cM)5
    2249121  NM_177638.41  NP_808306.11 
     570591055 


    ENSEMBL Gene Tree for CRB3 (if available)
    TreeFam Gene Tree for CRB3 (if available) 

    Paralogs
    for CRB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRB3 gene
    1 SIMAP similar gene for CRB3 using alignment to 1 protein entry:     CRUM3_HUMAN:
    CRB2

    CRB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CRB3
    PGOHUM00000237519


    Genomic Variants
    for CRB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/71 NCBI SNPs in CRB3 are shown (see all 71)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1467912921,2
    		--6462345(+) GTTCCC/TCCTAC 2 -- us2k10--------
    rs1896691491,2
    		--6462534(+) GGTATG/TTACAA 2 -- us2k10--------
    rs1849271,2
    		C,--6462664(+) ATGATA/GATGCA 2 -- us2k14Minor allele frequency- G:0.01MN NA WA 190
    rs1811475161,2
    		--6462779(+) AGTGGC/TGTGAT 2 -- us2k10--------
    rs1862861871,2
    		--6462863(+) ACAGGC/TGCCCA 2 -- us2k10--------
    rs4069741,2
    		C,F,H,--6462891(+) TTTTGT/ATTATT 2 -- us2k1 tfbs33Minor allele frequency- A:0.33NA 6
    rs3933751,2
    		C,F,H,--6462892(+) TTTGAA/TTATTT 2 -- us2k14Minor allele frequency- T:0.38WA NA 8
    rs2005002111,2
    		--6462892(+) TTTGA-/TTATTT 2 -- us2k10--------
    rs1865677151,2
    		--6462941(+) GGTCTC/GGAACT 2 -- us2k10--------
    rs1456949921,2
    		--6462942(+) GTCTCA/GAACTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CRB3 (6464260 - 6467232 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CRB3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRB3
    DNA2.0 Custom Variant and Variant Library Synthesis for CRB3

    Disorders / Diseases
    for CRB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CRB3 for disorders           About GeneDecksing

    OMIM gene information: 609737    OMIM disorders: --

    2 diseases for CRB3:    About MalaCards
    leber congenital amaurosis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CRB3:
    Leber congenital amaurosis

    Export disorders for CRB3 gene to outside databases

    Publications
    for CRB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRB3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CRB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. (PubMed id 14718572)1, 2 Lemmers C.... Le Bivic A. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). (PubMed id 12527193)1, 2 Makarova O.... Margolis B. (2003)
    4. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. (PubMed id 12771187)1, 2 Roh M.H.... Margolis B. (2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions. (PubMed id 17646395)1, 9 Fan S....Margolis B. (2007)
    7. The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. (PubMed id 17332497)1 Stucke V.M....Hall A. (2007)
    8. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. (PubMed id 17988153)1 Pardossi-Piquard R....Fraser P.E. (2007)
    9. Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells. (PubMed id 15976445)1 Fogg V.C....Margolis B. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for CRB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CRB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92359 HGNC: 20237 AceView: CRB3 Ensembl:ENSG00000130545 euGenes: HUgn92359
    ECgene: CRB3 Kegg: 92359 H-InvDB: CRB3

    Other Databases showing CRB3 gene

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    Specialized Databases showing CRB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    PharmGKB entry for CRB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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