Aliases for CRB2 Gene
External Ids for CRB2 Gene
Previous GeneCards Identifiers for CRB2 Gene
This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. [provided by RefSeq, Aug 2016]
GeneCards Summary for CRB2 Gene
CRB2 (Crumbs 2, Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with CRB2 include Ventriculomegaly With Cystic Kidney Disease and Focal Segmental Glomerulosclerosis 9. Among its related pathways are Hippo signaling pathway. GO annotations related to this gene include calcium ion binding and aspartic-type endopeptidase inhibitor activity. An important paralog of this gene is CRB1.
UniProtKB/Swiss-Prot for CRB2 Gene
May play a role in polarized cells morphogenesis.