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CRB2 Gene

protein-coding   GIFtS: 52
GCID: GC09P126118

Crumbs Family Member 2

(Previous name: crumbs homolog 2 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Crumbs Family Member 21 2
Crumbs-Like Protein 22 3
Crumbs Homolog 2 (Drosophila)1
Crumbs Homolog 22
Protein Crumbs Homolog 22

External Ids:    HGNC: 186881   Entrez Gene: 2862042   Ensembl: ENSG000001482047   OMIM: 6097205   UniProtKB: Q5IJ483   

Export aliases for CRB2 gene to outside databases

Previous GC identifers: GC09P121513 GC09P123198 GC09P125158 GC09P095733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CRB2 Gene:
CRB2 (crumbs family member 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
Function: May play a role in polarized cells morphogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CRB2 gene promoter:
         Max1   RFX1   Egr-1   Lmo2   POU6F1 (c2)   C/EBPalpha   MEF-2A   c-Myb   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRB2 promoter sequence
   Search Chromatin IP Primers for CRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.2

CRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRB2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126118:  view genomic region     (about GC identifiers)

Start:
126,118,448 bp from pter      End:
126,142,603 bp from pter
Size:
24,156 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48 (See protein sequence)
Recommended Name: Protein crumbs homolog 2 precursor  
Size: 1285 amino acids; 134265 Da
1 PDB 3D structure from and Proteopedia for CRB2:
2WO6 (3D)    
Secondary accessions: A2A3N4 Q0QD46 Q5JS41 Q5JS43 Q6ZTA9 Q6ZWI6
Alternative splicing: 3 isoforms:  Q5IJ48-1   Q5IJ48-2   Q5IJ48-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRB2: NX_Q5IJ48

Explore proteomics data for CRB2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn235, Asn438, Asn478, Asn669, Asn690, Asn786, Asn800, Asn836, Asn886, Asn926,
                                 Asn1009, Asn1141, Asn1158
  • Modification sites at PhosphoSitePlus

  • See CRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775960.4  
    ENSEMBL proteins: 
     ENSP00000353092   ENSP00000362734   ENSP00000435279   ENSP00000362732  

    CRB2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CRB2

     
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    antibodies-online peptides for CRB2

    CRB2 Antibody Products:

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    ThermoFisher Antibodies for CRB2
    antibodies-online antibodies for CRB2 (12 products) 

    CRB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CRB2
    Cloud-Clone Corp. CLIAs for CRB2
    Search eBioscience for ELISAs for CRB2 
    antibodies-online kits for CRB2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q5IJ48

    ProtoNet protein and cluster: Q5IJ48

    1 Blocks protein domain: IPB001791 Laminin G

    UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
    Similarity: Belongs to the Crumbs protein family
    Similarity: Contains 15 EGF-like domains
    Similarity: Contains 3 laminin G-like domains


    Find genes that share domains with CRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRUM2_HUMAN, Q5IJ48
    Function: May play a role in polarized cells morphogenesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CRB2           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crb2):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size/body  mortality/aging 
     nervous system  normal  pigmentation  vision/eye 

    Find genes that share phenotypes with CRB2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRB2:
    hsa-mir-335-5p (MIRT017520), hsa-mir-342-3p (MIRT043677)

    Block miRNA regulation of human, mouse, rat CRB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRB2 (see all 23):
    hsa-miR-4254 hsa-miR-125a-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCRB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CRB2
    Predesigned siRNA for gene silencing in human, mouse, rat CRB2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CRB2 (see all 4)
    OriGene ORF clones in mouse, rat for CRB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRB2 (NM_173689)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRB2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRB2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CRB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CRB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRUM2_HUMAN, Q5IJ48: Isoform 1: Cell membrane; Single-pass type I membrane protein
    CRUM2_HUMAN, Q5IJ48: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with CRB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for CRB2):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CRB2
    Interactions:

        Search GeneGlobe Interaction Network for CRB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CRB2 (Q5IJ483 ENSP000003627344) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation ISS--
    GO:0001756somitogenesis ISS--
    GO:0010718positive regulation of epithelial to mesenchymal transition ISS--
    GO:0014028notochord formation ISS--
    GO:0030513positive regulation of BMP signaling pathway ISS--

    Find genes that share ontologies with CRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRB2 (CRUM2)

    1 DrugBank Compound for CRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRB2 gene: 
    NM_173689.6  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359999(uc004bnw.1) ENST00000373631(uc004bnx.1) ENST00000460253
    ENST00000373629
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CRB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CRB2 (see all 23):
    hsa-miR-4254 hsa-miR-125a-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCRB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CRB2
    Predesigned siRNA for gene silencing in human, mouse, rat CRB2
    Clone
    Products:
         
    OriGene clones in human, mouse for CRB2 (see all 4)
    OriGene ORF clones in mouse, rat for CRB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CRB2 (NM_173689)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CRB2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CRB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CRB2
      QuantiTect SYBR Green Assays in human, mouse, rat CRB2
      QuantiFast Probe-based Assays in human, mouse, rat CRB2

    Selected AceView cDNA sequences (see all 32):

    AA721043 AA586428 BI063722 BF726291 AA931641 AA927420 AK095783 AK124819 
    AW026530 AK126775 AI880330 AA349361 BF726292 BQ184081 AW008664 BE396243 
    NM_173689 BQ695408 AA349362 BQ695404 BF341621 BF344465 BE392023 BF432706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGCAGTG
    CRB2 Expression
    About this image

    CRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRB2 Protein Expression

    UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
    Tissue specificity: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid
    cell lines, and at low levels in lung, placenta, and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CRB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crb21 , 5 crumbs homolog 2 (Drosophila)1, 5 80.8(n)1
    79.92(a)1
      2 (24.19 cM)5
    2413241  NM_001163566.11  NP_001157038.11 
     377762495 
    chicken
    (Gallus gallus)
    Aves CRB26
    crumbs homolog 2 (Drosophila)
    41(a)
    1 ↔ 1
    17(8989404-9014494)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Delta-like protein
    19(a)
    many ↔ many
    GL343568.1(290479-325945)
    zebrafish
    (Danio rerio)
    Actinopterygii fbn2a6
    CRB2 (7 of 7)6
    (see all 7)
    crumbs homolog 2 (Drosophila)
    (see all 7)
    8(a)
    41(a)
    (see all 7)
    1 ↔ many
    1 ↔ many
    (see all 7)
    10(16296083-16421372) ENSDARG00000051896
    21(4318106-4325054) ENSDARG00000089347
    fruit fly
    (Drosophila melanogaster)
    Insecta crb6
    crumbs
    20(a)
    1 ↔ 1
    3R(20120800-20140154)
    worm
    (Caenorhabditis elegans)
    Secernentea crb-16
    Protein CRB-1 (crb-1) mRNA, complete cds
    20(a)
    1 ↔ 1
    X(17402553-17413849) WBGene00000792


    ENSEMBL Gene Tree for CRB2 (if available)
    TreeFam Gene Tree for CRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRB2 gene
    DLK22  SNED12  NOTCH42  NOTCH12  DLL32  NOTCH32  JAG22  DLL42  
    DLK12  NOTCH22  JAG12  DNER2  CRB12  DLL12  
    4 SIMAP similar genes for CRB2 using alignment to 1 protein entry:     CRUM2_HUMAN:
    CNTNAP2    F9    CRB3    NOTCH2NL

    Find genes that share paralogs with CRB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRB2 (see all 772)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345255651,2
    C--95744073(+) ATCTC-/AAAAAA 1 -- int10--------
    rs1154337471,2
    C,F--126116570(+) GGAGAC/GTGGAC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1882643151,2
    --126116573(+) GACTGC/GACCTG 1 -- us2k10--------
    rs625799351,2
    C,F--126116581(+) CTGCGC/ACGGGT 1 -- us2k16Minor allele frequency- A:0.10NA WA EA 364
    rs1413887641,2
    C--126116607(+) TGAAA-/GTGTG 
     GGAGTTT
    GTGTC
    1 -- us2k10--------
    rs1928036161,2
    --126116613(+) TGTGGA/GAGTTT 1 -- us2k10--------
    rs1456362901,2
    --126116695(+) TGCCTA/GGGTCT 1 -- us2k10--------
    rs1404505981,2
    --126116787(+) AGACTG/TAGGCC 1 -- us2k10--------
    rs48380511,2
    C,F,A,H--126116865(+) TCTTAC/TGCTGT 1 -- us2k124Minor allele frequency- T:0.11NA NS EA WA 2782
    rs1114664611,2
    F--126116938(+) TTGTAC/TTGGAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for CRB2 (126118448 - 126142603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6707CNV Insertion18451855
    nsv518647CNV Loss19592680
    nsv893827CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CRB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CRB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609720    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for CRB2:
    Leber congenital amaurosis     Retinitis pigmentosa

    Find genes that share disorders with CRB2           About GenesLikeMe

    Genetic Association Database (GAD): CRB2
    Human Genome Epidemiology (HuGE) Navigator: CRB2 (2 documents)

    Export disorders for CRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRB2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis. (PubMed id 15851977)1, 2, 9 van den Hurk J.A.J.M.... den Hollander A.I. (Mol. Vis. 2005)
    2. Identification and characterization of Crumbs homolog 2 gene at human chromosome 9q33.3. (PubMed id 14767562)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2004)
    3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. (PubMed id 20299451)1 Mitsuishi Y....Nishimura M. (J. Biol. Chem. 2010)
    7. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    8. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. (PubMed id 17988153)1 Pardossi-Piquard R....Fraser P.E. (Biochemistry 2007)
    9. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. (PubMed id 17190600)1 Botuyan M.V....Mer G. (Cell 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286204 HGNC: 18688 AceView: CRB2 Ensembl:ENSG00000148204 euGenes: HUgn286204
    ECgene: CRB2 Kegg: 286204 H-InvDB: CRB2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CRB2 gene:
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