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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRB2 Gene

protein-coding   GIFtS: 53
GCID: GC09P126118

Crumbs Homolog 2 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Crumbs Homolog 2 (Drosophila)1 2
Crumbs-Like Protein 22 3
Protein Crumbs Homolog 22

External Ids:    HGNC: 186881   Entrez Gene: 2862042   Ensembl: ENSG000001482047   OMIM: 6097205   UniProtKB: Q5IJ483   

Export aliases for CRB2 gene to outside databases

Previous GC identifers: GC09P121513 GC09P123198 GC09P125158 GC09P095733


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CRB2 Gene: 
CRB2 (crumbs homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with CRB2 include leber congenital amaurosis, and cleft lip. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EYS.

UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
Function: May play a role in polarized cells morphogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRB2 gene promoter:
         Max1   RFX1   Egr-1   Lmo2   POU6F1 (c2)   C/EBPalpha   MEF-2A   c-Myb   aMEF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CRB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CRB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.2

CRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRB2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126118:  view genomic region     (about GC identifiers)

Start:
126,118,448 bp from pter      End:
126,142,603 bp from pter
Size:
24,156 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48 (See protein sequence)
Recommended Name: Protein crumbs homolog 2 precursor  
Size: 1285 amino acids; 134265 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
1 PDB 3D structure from and Proteopedia for CRB2:
2WO6 (3D)    
Secondary accessions: A2A3N4 Q0QD46 Q5JS41 Q5JS43 Q6ZTA9 Q6ZWI6
Alternative splicing: 3 isoforms:  Q5IJ48-1   Q5IJ48-2   Q5IJ48-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRB2: NX_Q5IJ48

Explore proteomics data for CRB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5IJ48

  • CRB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRB2 Protein Expression
    REFSEQ proteins: NP_775960.4  
    ENSEMBL proteins: 
     ENSP00000353092   ENSP00000362734   ENSP00000435279   ENSP00000362732  

    Human Recombinant Protein Products for CRB2: 
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    Cloud-Clone Corp. Proteins for CRB2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CRB2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CRB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS

    Graphical View of Domain Structure for InterPro Entry Q5IJ48

    ProtoNet protein and cluster: Q5IJ48

    1 Blocks protein domain: IPB001791 Laminin G

    UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
    Similarity: Belongs to the Crumbs protein family
    Similarity: Contains 15 EGF-like domains
    Similarity: Contains 3 laminin G-like domains


    CRB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRUM2_HUMAN, Q5IJ48
    Function: May play a role in polarized cells morphogenesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    CRB2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crb2):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size  mortality/aging 
     nervous system  normal  pigmentation  vision/eye 

    CRB2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRB2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRB2 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CRB2
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate CRB2 (see all 23):
    hsa-miR-4254 hsa-miR-125a-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCRB2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for CRB2):
        Hippo signaling pathway


    CRB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRB2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/17 Interacting proteins for CRB2 (Q5IJ483 ENSP000003627344) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRB2 (CRUM2)

    1 DrugBank Compound for CRB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CRB2 / CRUM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CRB2 gene: 
    NM_173689.5  

    Unigene Cluster for CRB2:

    Crumbs homolog 2 (Drosophila)
    Hs.710092  [show with all ESTs]
    Unigene Representative Sequence: NM_173689
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359999(uc004bnw.1) ENST00000373631(uc004bnx.1) ENST00000460253
    ENST00000373629
    miRNA
    Products:
         
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate CRB2 (see all 23):
    hsa-miR-4254 hsa-miR-125a-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCRB2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CRB2
    Sirion Biotech Customized lentivirus for stable overexpression of CRB2 
                         Customized lentivirus expression plasmids for stable overexpression of CRB2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CRB2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRB2

    Additional mRNA sequence: 

    AK095783.1 AK123000.1 AK124819.1 AK126775.1 AY720432.1 

    2 DOTS entries:

    DT.97775951  DT.91974994 

    24/32 AceView cDNA sequences (see all 32):

    AK095783 AA927420 AK124819 AW026530 AA721043 BF726291 AA586428 AA931641 
    BI063722 AA349361 BQ184081 BQ695404 BF344465 BF432706 BE392023 AW008664 
    AK126775 BF341621 AI880330 BQ695408 BF726292 AK123000 AA349362 NM_173689 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRB2 expression in normal human tissues (normalized intensities)      CRB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGCAGTG
    CRB2 Expression
    About this image


    CRB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See CRB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRB2

    SOURCE GeneReport for Unigene cluster: Hs.710092

    UniProtKB/Swiss-Prot: CRUM2_HUMAN, Q5IJ48
    Tissue specificity: Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid
    cell lines, and at low levels in lung, placenta, and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CRB2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crb21 , 5 crumbs homolog 2 (Drosophila)1, 5 80.63(n)1
    79.73(a)1
      2 (24.19 cM)5
    2413241  NM_001163566.11  NP_001157038.11 
     377762495 
    chicken
    (Gallus gallus)
    Aves CRB21 crumbs homolog 2 (Drosophila) 54.67(n)
    48.39(a)
      417104  XM_415389.3  XP_415389.3 
    lizard
    (Anolis carolinensis)
    Reptilia CRB26
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL344112.1(44-12270)
    zebrafish
    (Danio rerio)
    Actinopterygii crb2a1 crumbs homolog 2a 49.71(n)
    43.98(a)
      723994  NM_001045299.1  NP_001038764.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta uif6
    crb6
    crumbs
    6(a)
    17(a)
    possible ortholog
    1 ↔ 1
    2L(6972828-7010312)
    3R(20120800-20140154)
    worm
    (Caenorhabditis elegans)
    Secernentea F47C12.16
    lin-126
    (see all 3)
    Protein lin-12
    (see all 3)
    7(a)
    13(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    IV(3998620-4014221)
    III(9060242-9071760)


    ENSEMBL Gene Tree for CRB2 (if available)
    TreeFam Gene Tree for CRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRB2 gene
    EYS2  NOTCH42  NOTCH2NL2  NOTCH12  NOTCH32  NOTCH22  ENSG000002551682  CRB12  
    4 SIMAP similar genes for CRB2 using alignment to 1 protein entry:     CRUM2_HUMAN:
    CNTNAP2    F9    CRB3    NOTCH2NL

    CRB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 SNPs in CRB2 are shown (see all 772)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0229854
    ----see VAR_0229852 V L mis40--------
    VAR_0229904
    ----see VAR_0229902 A T mis40--------
    VAR_0229894
    ----see VAR_0229892 E D mis40--------
    VAR_0229934
    ----see VAR_0229932 H Q mis40--------
    VAR_0229914
    ----see VAR_0229912 R Q mis40--------
    VAR_0229864
    ----see VAR_0229862 P L mis40--------
    rs345255651,2
    C--95744073(+) ATCTC-/AAAAAA 1 -- int10--------
    rs1154337471,2
    C,F--126116570(+) GGAGAC/GTGGAC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1882643151,2
    --126116573(+) GACTGC/GACCTG 1 -- us2k10--------
    rs625799351,2
    C,F--126116581(+) CTGCGC/ACGGGT 1 -- us2k16Minor allele frequency- A:0.10NA WA EA 364

    HapMap Linkage Disequilibrium report for CRB2 (126118448 - 126142603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CRB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6707CNV Insertion18451855
    nsv518647CNV Loss19592680
    nsv893827CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609720    OMIM disorders: --

    5 diseases for CRB2:    About MalaCards
    leber congenital amaurosis    cleft lip    choroiditis    retinitis pigmentosa
    retinitis

    2 diseases from the University of Copenhagen DISEASES database for CRB2:
    Leber congenital amaurosis     Retinitis pigmentosa

    CRB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CRB2
    Human Genome Epidemiology (HuGE) Navigator: CRB2 (2 documents)

    Export disorders for CRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRB2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis. (PubMed id 15851977)1, 2, 9 van den Hurk J.A.J.M.... den Hollander A.I. (2005)
    2. Identification and characterization of Crumbs homolog 2 gene at human chromosome 9q33.3. (PubMed id 14767562)1, 3, 9 Katoh M. and Katoh M. (2004)
    3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Human CRB2 inhibits gamma-secretase cleavage of amylo id precursor protein by binding to the presenilin complex. (PubMed id 20299451)1 Mitsuishi Y....Nishimura M. (2010)
    7. Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. (PubMed id 17988153)1 Pardossi-Piquard R....Fraser P.E. (2007)
    8. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. (PubMed id 17190600)1 Botuyan M.V....Mer G. (2006)
    9. Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner. (PubMed id 11439336)1 Crostella L....Skouteris G.G. (2001)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 286204 HGNC: 18688 AceView: CRB2 Ensembl:ENSG00000148204 euGenes: HUgn286204
    ECgene: CRB2 Kegg: 286204 H-InvDB: CRB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CRB2 gene:
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