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CRAT Gene

protein-coding   GIFtS: 65
GCID: GC09M131857

Carnitine O-Acetyltransferase

(Previous name: carnitine acetyltransferase)
  See CRAT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carnitine O-Acetyltransferase1 2     CAT2 3
Carnitine Acetyltransferase1 2 3     EC 2.3.1.73 8
CAT12 3 5     CrAT3
Carnitine Acetylase2 3     EC 2.3.18

External Ids:    HGNC: 23421   Entrez Gene: 13842   Ensembl: ENSG000000953217   OMIM: 6001845   UniProtKB: P431553   

Export aliases for CRAT gene to outside databases

Previous GC identifers: GC09M122971 GC09M123503 GC09M125310 GC09M127233 GC09M128936 GC09M130896 GC09M101464


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CRAT Gene:
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in
mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from
an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for CRAT Gene:
CRAT (carnitine O-acetyltransferase) is a protein-coding gene. Diseases associated with CRAT include acetyl-carnitine deficiency, and carnitine palmitoyltransferase 1a deficiency. GO annotations related to this gene include carnitine O-acetyltransferase activity and receptor binding. An important paralog of this gene is CROT.

UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the
flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into
mitochondria

Gene Wiki entry for CRAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CRAT gene promoter:
         NF-kappaB   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRAT promoter sequence
   Search Chromatin IP Primers for CRAT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CRAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.1

CRAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRAT gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131857:  view genomic region     (about GC identifiers)

Start:
131,857,073 bp from pter      End:
131,873,468 bp from pter
Size:
16,396 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CACP_HUMAN, P43155 (See protein sequence)
Recommended Name: Carnitine O-acetyltransferase  
Size: 626 amino acids; 70858 Da
Subunit: Monomer
2 PDB 3D structures from and Proteopedia for CRAT:
1NM8 (3D)        1S5O (3D)    
Secondary accessions: Q5T952 Q9BW16
Alternative splicing: 3 isoforms:  P43155-1   P43155-2   P43155-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRAT: NX_P43155

Explore proteomics data for CRAT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CRAT (P43155) (see all 13)
     HITVVHN  DRHLLGL  QLEKIWN  LPVPPLQQ 


    See CRAT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000746.2  NP_001244292.1  

    ENSEMBL proteins: 
     ENSP00000315013   ENSP00000395458   ENSP00000400367   ENSP00000394420   ENSP00000404405  
     ENSP00000377045   ENSP00000390571  
    Reactome Protein details: P43155

    CRAT Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CRAT

     
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    antibodies-online proteins for CRAT (6 products) 

     
    antibodies-online peptides for CRAT

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000542 Carn_acyl_trans

    Graphical View of Domain Structure for InterPro Entry P43155

    ProtoNet protein and cluster: P43155

    1 Blocks protein domain: IPB000542 Acyltransferase ChoActase/COT/CPT

    UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
    Similarity: Belongs to the carnitine/choline acetyltransferase family


    Find genes that share domains with CRAT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACP_HUMAN, P43155
    Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the
    flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into
    mitochondria
    Catalytic activity: Acetyl-CoA + carnitine = CoA + O-acetylcarnitine

         Genatlas biochemistry entry for CRAT:
    carnitine acetyltransferase,localized in mitochondrial matrix,peroxisomes,and endoplasmic reticulum,specific for
    short chain fatty acyl-CoA (C2-C14)

         Enzyme Numbers (IUBMB): EC 2.3.1.71 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004092carnitine O-acetyltransferase activity IDA15099582
    GO:0005102receptor binding IPI--
    GO:0016746transferase activity, transferring acyl groups ----
         
    Find genes that share ontologies with CRAT           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crat):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with CRAT           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CRAT

    miRNA
    Products:
        
    miRTarBase miRNAs that target CRAT:
    hsa-mir-155-5p (MIRT020803)

    Block miRNA regulation of human, mouse, rat CRAT using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CRAT:
    hsa-miR-124 hsa-miR-506 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCRAT 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CRAT (NM_000755)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRAT

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRAT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CACP_HUMAN, P43155: Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion inner membrane;
    Peripheral membrane protein; Matrix side (Potential)
    CACP_HUMAN, P43155: Isoform 1: Mitochondrion (Potential)
    CACP_HUMAN, P43155: Isoform 2: Peroxisome (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome4
    endoplasmic reticulum3
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005777peroxisome IDA2351134
    GO:0005782peroxisomal matrix TAS--
    GO:0005783endoplasmic reticulum IEA--

    Find genes that share ontologies with CRAT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CRAT About    
    See pathways by source

    SuperPathContained pathways About
    1Peroxisomal lipid metabolism
    Peroxisomal lipid metabolism
    Beta-oxidation of very long chain fatty acids0.00
    Beta-oxidation of pristanoyl-CoA0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Mitochondrial LC-Fatty Acid Beta-Oxidation
    Fatty Acid Beta Oxidation0.35
    4Peroxisome
    Peroxisome
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with CRAT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CRAT
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for CRAT
        Fatty Acid Beta Oxidation


    2 Reactome Pathways for CRAT
        Beta-oxidation of very long chain fatty acids
    Beta-oxidation of pristanoyl-CoA


    1 Kegg Pathway  (Kegg details for CRAT):
        Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRAT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CRAT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CRAT (P431553 ENSP000003150134) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL34P492073, ENSP000003781604I2D: score=2 STRING: ENSP00000378160
    EIF2B2P497703, ENSP000002661264I2D: score=2 STRING: ENSP00000266126
    PDHA2P298033, ENSP000002952664I2D: score=1 STRING: ENSP00000295266
    KPNA6O606843I2D: score=6 
    ABCA3Q997583I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0019254carnitine metabolic process, CoA-linked IDA15099582
    GO:0033540fatty acid beta-oxidation using acyl-CoA oxidase TAS--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CRAT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CRAT (CACP)

    7 HMDB Compounds for CRAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    L-Acetylcarnitine(-)-Acetylcarnitine (see all 14)3040-38-8--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    Phytanoyl-CoAPhytanoyl-coenzyme A (see all 8)146622-45-9--
    Propionyl-CoAPropionyl-CoA (see all 8)317-66-8--
    Propionylcarnitine(+/-)-Propionylcarnitine chloride (see all 8)17298-37-2--

    3 DrugBank Compounds for CRAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--15099582 12562770 12582227 12526798 15155769
    (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium-- 461-06-3target--17139284 17016423 10592235
    Coenzyme A-- 85-61-0target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CRAT gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 96.9 830 1427600 (2), 7776973 (2), 19332670 (2), 2123391 (2) (see all 99)
    carnitine 74.8 194 2351134 (6), 1822803 (4), 2325817 (4), 9059510 (4) (see all 64)
    acetyl-l-carnitine 58 13 11121899 (3), 1456745 (1), 10452805 (1), 8239306 (1) (see all 7)
    thymidine 57.1 40 1550597 (1), 7684926 (1), 7608251 (1), 8923463 (1) (see all 33)
    acetyl-coa 53 24 1822803 (2), 19912061 (2), 2351134 (1), 1489081 (1) (see all 15)
    oligonucleotide 49.9 8 17854268 (1), 2142416 (1), 7737192 (1), 2153928 (1) (see all 7)
    12-o-tetradecanoylphorbol 13-acetate 49.6 18 8380829 (2), 1618329 (1), 8955111 (1), 1939341 (1) (see all 12)
    cafestol 43.9 3 9555953 (1), 9351383 (1)
    estrogen 43.3 49 9010318 (3), 9015389 (2), 1572285 (2), 9195474 (2) (see all 30)
    dc-chol 43 4 8332495 (2), 8185568 (1)



    Find genes that share compounds with CRAT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CRAT gene (4 alternative transcripts): 
    NM_000755.3  NM_001257363.1  NM_004003.2  NM_144782.1  

    Unigene Cluster for CRAT:

    Carnitine O-acetyltransferase
    Hs.12068  [show with all ESTs]
    Unigene Representative Sequence: NM_001257363
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318080(uc004bxk.4 uc004bxh.3) ENST00000455396 ENST00000458362
    ENST00000467343 ENST00000464290 ENST00000415948(uc004bxj.2) ENST00000441796
    ENST00000393384 ENST00000455830
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    SwitchGear 3'UTR luciferase reporter plasmidCRAT 3' UTR sequence
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CRAT

    Additional mRNA sequence: 

    AK313931.1 BC000723.2 BT006801.1 DQ655950.2 DQ655951.2 X78706.1 

    14 DOTS entries:

    DT.314546  DT.100780326  DT.100780322  DT.100829697  DT.70100861  DT.100769621  DT.121146271  DT.121146254 
    DT.91750229  DT.101973542  DT.40108104  DT.95249687  DT.95249711  DT.65288393 

    Selected AceView cDNA sequences (see all 273):

    AA353269 BU733153 CB243402 BU517016 BE531148 BQ929844 CF125676 BG696822 
    BG740824 AI860023 AI278072 AI419719 BI829245 AI041268 AW664936 AI492549 
    BG741927 BG698849 BU527511 CD609491 AI027659 AI291920 BM857108 BG742598 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CRAT (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                                  -                                                                                                         
    SP2:                          -     -     -           -                                                     -     -                                             
    SP3:                                -     -           -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 17b · 17c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CRAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CRAT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRAT Expression
    About this image


    CRAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    CRAT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CRAT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12068

    UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
    Tissue specificity: Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain,
    placenta, lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CRAT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CRAT
    OriGene qSTAR qPCR primer pairs in human, mouse for CRAT
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRAT gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crat1 , 5 carnitine acetyltransferase1, 5 86.42(n)1
    91.05(a)1
      2 (21.69 cM)5
    129081  NM_007760.31  NP_031786.21 
     304004715 
    chicken
    (Gallus gallus)
    Aves CRAT1 carnitine O-acetyltransferase 73.91(n)
    78.12(a)
      417195  XM_004945865.1  XP_004945922.1 
    lizard
    (Anolis carolinensis)
    Reptilia CRAT6
    carnitine O-acetyltransferase
    79(a)
    1 ↔ 1
    GL344059.1(43449-61539)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB180322.12   -- 73.25(n)    CB180322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh02482 hmzeh0248 76.52(n)   321373  CK028362.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51221 , 3 carnitine O-acetyltransferase3
    CG51221
    40(a)
    (best of 4)3
    50.65(n)1
    40.28(a)1
      347031  NM_135757.31  NP_609601.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0395.31 , 3 choline O-acetyltransferase3
    B0395.31
    37(a)
    (best of 2)3
    47.85(n)1
    39.59(a)1
      X(16066025-16070026)3
    1816821  NM_078223.31  NP_510624.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAT2(YML042W)4
    CAT21
    Carnitine acetyl-CoA transferase present in both mitochondria more4
    CAT21
    42.6(n)1
    33.28(a)1
      13(192788-194800)4
    8549651, 4  NP_013670.11, 4 


    ENSEMBL Gene Tree for CRAT (if available)
    TreeFam Gene Tree for CRAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CRAT gene
    CROT2  CPT1C2  CPT1B2  CPT1A2  CHAT2  
    7 SIMAP similar genes for CRAT using alignment to 6 protein entries:     CACP_HUMAN (see all proteins):
    ChAT    CHAT    CROT    CPT1A    CPT1B    CPT2
    CPT1C

    Find genes that share paralogs with CRAT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CRAT (see all 462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109882001,2
    C,F,H--101463555(+) GGACAT/CGGGGC 1 -- ds500115Minor allele frequency- C:0.43NS EA NA WA CSA 969
    rs175085161,2
    C,F,H--101463591(+) TGATCG/ACACCT 1 -- ds50015Minor allele frequency- A:0.03NS EA WA 536
    rs1929394461,2
    C--101463618(+) GTCTGC/TCCTGG 1 -- ds50010--------
    rs1476251741,2
    --101463627(+) GGCAGC/TGGCTG 1 -- ds50010--------
    rs1846301121,2
    --101463629(+) CAGCGC/GCTGGG 1 -- ds50010--------
    rs175085231,2
    C,F--101463727(+) TTAGCA/CACATT 1 -- ds50012Minor allele frequency- C:0.15CSA WA 120
    rs31244961,2
    C,F,A,H--101463832(+) AGAGGT/CAGGTG 1 -- ds500110Minor allele frequency- C:0.22NS NA WA CSA EA 490
    rs123428251,2
    C,F,H--101463857(+) AAGGAC/TGCAGC 1 -- ds50017Minor allele frequency- T:0.00NS EA NA 598
    rs174860381,2
    C,F,H--101463886(+) CTGGGC/ACCAGT 1 -- ds50016Minor allele frequency- A:0.08NS EA WA 536
    rs31244971,2
    C,H--101463946(+) CCACCG/AGCTGC 1 -- ds500113Minor allele frequency- A:0.00NS EA NA WA CSA 669

    HapMap Linkage Disequilibrium report for CRAT (131857073 - 131873468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CRAT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509323CNV Insertion20534489
    nsv831729CNV Loss17160897
    nsv818725CNV Gain17921354
    nsv893902CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600184    OMIM disorders: --

    6 diseases for CRAT:    
    About MalaCards
    acetyl-carnitine deficiency    carnitine palmitoyltransferase 1a deficiency    overnutrition    thyroid hormone resistance syndrome
    parainfluenza virus type 3    thyroid medullary carcinoma


    Find genes that share disorders with CRAT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CRAT gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma rous 60.1 7 2159467 (1), 11395331 (1), 2187480 (1), 2173259 (1) (see all 6)
    immunodeficiency 54.2 12 2219731 (1), 1705476 (1), 1654446 (1), 10028058 (1) (see all 11)
    leukemia t-cell 52.5 3 8382621 (1), 8494821 (1), 2209540 (1)
    mammary tumor 48.6 20 2159467 (1), 2172802 (1), 1843211 (1), 1372436 (1) (see all 15)
    visna 38 1 1316669 (1)
    hepatoblastoma 37.8 2 8286041 (1), 10400991 (1)
    choriocarcinoma 36.9 5 7588308 (1), 15971268 (1), 8603036 (1), 1964488 (1) (see all 5)
    herpes simplex 36.3 9 11598449 (1), 1584226 (1), 8920984 (1), 10028058 (1) (see all 9)
    erythroleukemia 32.4 4 7945385 (1), 8651934 (1), 7524502 (1)
    carcinoma embryonal 29.7 1 1804740 (1)

    Genetic Association Database (GAD): CRAT
    Human Genome Epidemiology (HuGE) Navigator: CRAT (5 documents)

    Export disorders for CRAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CRAT gene, integrated from 10 sources (see all 611):
    (articles sorted by number of sources associating them with CRAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1. (PubMed id 7829107)1, 2, 3, 9 Corti O.... Didonato S. (Genomics 1994)
    2. Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. (PubMed id 12562770)1, 2, 7, 9 Wu D....McKenna R. (J. Biol. Chem. 2003)
    3. Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. (PubMed id 15099582)1, 2, 7, 9 Govindasamy L.... Wu D. (J. Struct. Biol. 2004)
    4. Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations. (PubMed id 7945262)1, 2, 9 Corti O.... Finocchiaro G. (Biochem. J. 1994)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. (PubMed id 12526798)1, 7 Jogl G. and Tong L. (Cell 2003)
    10. Purification and properties of carnitine acetyltransferase from human liver. (PubMed id 2351134)1, 9 Bloisi W....Didonato S. (Eur. J. Biochem. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1384 HGNC: 2342 AceView: CRAT Ensembl:ENSG00000095321 euGenes: HUgn1384
    ECgene: CRAT Kegg: 1384 H-InvDB: CRAT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CRAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CRAT gene:
    Search GeneIP for patents involving CRAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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