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Aliases for CRAT Gene

Aliases for CRAT Gene

  • Carnitine O-Acetyltransferase 2 3 5
  • Carnitine Acetyltransferase 2 3 4
  • Carnitine Acetylase 3 4
  • EC 2.3.1.7 4 63
  • CAT1 3 4
  • CAT 3 4
  • EC 2.3.1 63
  • CrAT 4

External Ids for CRAT Gene

Previous GeneCards Identifiers for CRAT Gene

  • GC09M122971
  • GC09M123503
  • GC09M125310
  • GC09M127233
  • GC09M128936
  • GC09M130896
  • GC09M131857
  • GC09M101464

Summaries for CRAT Gene

Entrez Gene Summary for CRAT Gene

  • This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CRAT Gene

CRAT (Carnitine O-Acetyltransferase) is a Protein Coding gene. Diseases associated with CRAT include carnitine acetyltransferase deficiency and overnutrition. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include receptor binding and carnitine O-acetyltransferase activity. An important paralog of this gene is CHAT.

UniProtKB/Swiss-Prot for CRAT Gene

  • Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

Gene Wiki entry for CRAT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRAT Gene

Genomics for CRAT Gene

Regulatory Elements for CRAT Gene

Promoters for CRAT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CRAT on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CRAT gene promoter:

Genomic Location for CRAT Gene

Chromosome:
9
Start:
129,094,794 bp from pter
End:
129,111,189 bp from pter
Size:
16,396 bases
Orientation:
Minus strand

Genomic View for CRAT Gene

Genes around CRAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRAT Gene

Proteins for CRAT Gene

  • Protein details for CRAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43155-CACP_HUMAN
    Recommended name:
    Carnitine O-acetyltransferase
    Protein Accession:
    P43155
    Secondary Accessions:
    • Q5T952
    • Q9BW16

    Protein attributes for CRAT Gene

    Size:
    626 amino acids
    Molecular mass:
    70858 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CRAT Gene

    Alternative splice isoforms for CRAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRAT Gene

Proteomics data for CRAT Gene at MOPED

Post-translational modifications for CRAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CRAT

Domains & Families for CRAT Gene

Protein Domains for CRAT Gene

Suggested Antigen Peptide Sequences for CRAT Gene

Graphical View of Domain Structure for InterPro Entry

P43155

UniProtKB/Swiss-Prot:

CACP_HUMAN :
  • Belongs to the carnitine/choline acetyltransferase family.
Family:
  • Belongs to the carnitine/choline acetyltransferase family.
genes like me logo Genes that share domains with CRAT: view

No data available for Gene Families for CRAT Gene

Function for CRAT Gene

Molecular function for CRAT Gene

GENATLAS Biochemistry:
carnitine acetyltransferase,localized in mitochondrial matrix,peroxisomes,and endoplasmic reticulum,specific for short chain fatty acyl-CoA (C2-C14)
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.
UniProtKB/Swiss-Prot Function:
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

Enzyme Numbers (IUBMB) for CRAT Gene

Gene Ontology (GO) - Molecular Function for CRAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
genes like me logo Genes that share ontologies with CRAT: view
genes like me logo Genes that share phenotypes with CRAT: view

Animal Model Products

miRNA for CRAT Gene

miRTarBase miRNAs that target CRAT

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRAT Gene

Localization for CRAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRAT Gene

Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Isoform 1: Mitochondrion.
Isoform 2: Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRAT Gene COMPARTMENTS Subcellular localization image for CRAT gene
Compartment Confidence
mitochondrion 5
peroxisome 5
endoplasmic reticulum 3
nucleus 3
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CRAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with CRAT: view

Pathways & Interactions for CRAT Gene

genes like me logo Genes that share pathways with CRAT: view

Gene Ontology (GO) - Biological Process for CRAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with CRAT: view

No data available for SIGNOR curated interactions for CRAT Gene

Drugs & Compounds for CRAT Gene

(63) Drugs for CRAT Gene - From: Novoseek, DrugBank, HMDB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Carnitine Approved Pharma Target 0
Acetylcarnitine Approved, Investigational Pharma 39
(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium Experimental Pharma Target 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra Target 0

(57) Additional Compounds for CRAT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
Phytanoyl-CoA
  • 3,7,11,15-Tetramethyl hexadecanoyl CoA
  • 3,7,11,15-Tetramethyl hexadecanoyl coenzyme A
  • Phytanoyl CoA
  • Phytanoyl Coenzyme A
  • Phytanoyl-CoA
146622-45-9
Propionylcarnitine
  • (+/-)-Propionylcarnitine chloride
  • (3-carboxy-2-hydroxypropyl)trimethyl-hydroxide Ammonium inner salt
  • 3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt
  • L-Propionylcarnitine
  • O-Propanoylcarnitine
17298-37-2
genes like me logo Genes that share compounds with CRAT: view

Transcripts for CRAT Gene

Unigene Clusters for CRAT Gene

Carnitine O-acetyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRAT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: -
SP6: - -
SP7: -
SP8: - - -

ExUns: 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CRAT Gene

GeneLoc Exon Structure for
CRAT
ECgene alternative splicing isoforms for
CRAT

Expression for CRAT Gene

mRNA expression in normal human tissues for CRAT Gene

mRNA differential expression in normal tissues according to GTEx for CRAT Gene

This gene is overexpressed in Muscle - Skeletal (x5.0).

Protein differential expression in normal tissues from HIPED for CRAT Gene

This gene is overexpressed in Heart (10.9), Tonsil (8.3), and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CRAT Gene



SOURCE GeneReport for Unigene cluster for CRAT Gene Hs.12068

mRNA Expression by UniProt/SwissProt for CRAT Gene

P43155-CACP_HUMAN
Tissue specificity: Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.
genes like me logo Genes that share expression patterns with CRAT: view

Protein tissue co-expression partners for CRAT Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CRAT Gene

Orthologs for CRAT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CRAT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CRAT 35
  • 89.51 (n)
  • 92.81 (a)
MGC142781 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CRAT 35
  • 89.3 (n)
  • 93.29 (a)
CRAT 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crat 35
  • 86.42 (n)
  • 91.05 (a)
Crat 16
Crat 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CRAT 35
  • 99.36 (n)
  • 99.04 (a)
CRAT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crat 35
  • 86.26 (n)
  • 90.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CRAT 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRAT 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRAT 35
  • 73.91 (n)
  • 78.12 (a)
CRAT 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRAT 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crat.1 35
  • 73.17 (n)
  • 79.04 (a)
zebrafish
(Danio rerio)
Actinopterygii crata 35
  • 71.19 (n)
  • 73.32 (a)
hmzeh0248 35
CRAT (2 of 3) 36
  • 67 (a)
OneToMany
crata 36
  • 73 (a)
OneToMany
cratb 36
  • 54 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9411 35
fruit fly
(Drosophila melanogaster)
Insecta CG1041 37
  • 35 (a)
CG5122 37
  • 40 (a)
CG5265 37
  • 34 (a)
Cha 37
  • 35 (a)
CG5122 35
  • 50.65 (n)
  • 40.28 (a)
CG1041 36
  • 34 (a)
ManyToMany
CG5122 36
  • 19 (a)
ManyToMany
CG5265 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0395.3 37
  • 37 (a)
cha-1 37
  • 31 (a)
B0395.3 35
  • 47.85 (n)
  • 39.59 (a)
B0395.3 36
  • 37 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR124C 35
  • 47.34 (n)
  • 33.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02123g 35
  • 41.08 (n)
  • 33.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAT2 35
  • 42.6 (n)
  • 33.28 (a)
CAT2 36
  • 28 (a)
OneToMany
CAT2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15540 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08002 35
  • 52.86 (n)
  • 37.59 (a)
Species with no ortholog for CRAT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRAT Gene

ENSEMBL:
Gene Tree for CRAT (if available)
TreeFam:
Gene Tree for CRAT (if available)

Paralogs for CRAT Gene

Paralogs for CRAT Gene

(7) SIMAP similar genes for CRAT Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CRAT: view

Variants for CRAT Gene

Sequence variations from dbSNP and Humsavar for CRAT Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3118635 - 129,098,622(+) CACCA(A/G/T)GGGAG reference, missense
rs17459086 - 129,095,408(+) CTTGG(C/G)CCGGG reference, missense
rs719494 -- 129,102,826(-) TTATT(C/T)GCTGC intron-variant
rs746871 -- 129,102,760(-) GATGA(C/T)TTCTG intron-variant
rs746872 -- 129,102,748(-) ACAGG(A/G)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CRAT Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
nsv818725 CNV Gain 17921354

Variation tolerance for CRAT Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CRAT Gene

HapMap Linkage Disequilibrium report
CRAT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRAT Gene

Disorders for CRAT Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRAT Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
carnitine acetyltransferase deficiency
overnutrition
pseudotumor cerebri
  • benign intracran. hypt.
- elite association - COSMIC cancer census association via MalaCards
Search CRAT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CRAT

Genetic Association Database (GAD)
CRAT
Human Genome Epidemiology (HuGE) Navigator
CRAT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CRAT
genes like me logo Genes that share disorders with CRAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRAT Gene

Publications for CRAT Gene

  1. Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1. (PMID: 7829107) Corti O. … Didonato S. (Genomics 1994) 2 3 4 23 67
  2. Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. (PMID: 15099582) Govindasamy L. … Wu D. (J. Struct. Biol. 2004) 3 23 25 26
  3. Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. (PMID: 12562770) Wu D. … McKenna R. (J. Biol. Chem. 2003) 3 23 25 26
  4. Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. (PMID: 12526798) Jogl G. … Tong L. (Cell 2003) 3 25 26
  5. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. (PMID: 19553674) Noland R.C. … Muoio D.M. (J. Biol. Chem. 2009) 3 23

Products for CRAT Gene

Sources for CRAT Gene

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