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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CRAT Gene

protein-coding   GIFtS: 67
GCID: GC09M131857

Carnitine O-Acetyltransferase

(Previous name: carnitine acetyltransferase)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Carnitine O-Acetyltransferase1 2     CAT2 3
Carnitine Acetyltransferase1 2 3     EC 2.3.1.73 8
CAT12 3 5     CrAT3
Carnitine Acetylase2 3     EC 2.3.18

External Ids:    HGNC: 23421   Entrez Gene: 13842   Ensembl: ENSG000000953217   OMIM: 6001845   UniProtKB: P431553   
ORGUL members:         
NONCODE14:n408115      

Export aliases for CRAT gene to outside databases

Previous GC identifers: GC09M122971 GC09M123503 GC09M125310 GC09M127233 GC09M128936 GC09M130896 GC09M101464


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRAT Gene:
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in
mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from
an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for CRAT Gene: 
CRAT (carnitine O-acetyltransferase) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CRAT include carnitine palmitoyltransferase 1a deficiency, and marek disease, and among its related super-pathways are Metabolic pathways and Beta-oxidation of pristanoyl-CoA. GO annotations related to this gene include carnitine O-acetyltransferase activity and receptor binding. An important paralog of this gene is CROT.

UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the
flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into
mitochondria

Gene Wiki entry for CRAT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRAT gene promoter:
         NF-kappaB   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCRAT promoter sequence
   Search SABiosciences Chromatin IP Primers for CRAT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRAT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.1

CRAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRAT gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131857:  view genomic region     (about GC identifiers)

Start:
131,857,073 bp from pter      End:
131,873,468 bp from pter
Size:
16,396 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CACP_HUMAN, P43155 (See protein sequence)
Recommended Name: Carnitine O-acetyltransferase  
Size: 626 amino acids; 70858 Da
Subunit: Monomer
Subcellular location: Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion inner membrane;
Peripheral membrane protein; Matrix side (Potential)
Subcellular location: Isoform 1: Mitochondrion (Potential)
Subcellular location: Isoform 2: Peroxisome (Potential)
2 PDB 3D structures from and Proteopedia for CRAT:
1NM8 (3D)        1S5O (3D)    
Secondary accessions: Q5T952 Q9BW16
Alternative splicing: 3 isoforms:  P43155-1   P43155-2   P43155-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CRAT: NX_P43155

Explore proteomics data for CRAT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43155

  • 4/13 DME Specific Peptides for CRAT (P43155) (see all 13)
     HITVVHN  DRHLLGL  QLEKIWN  LPVPPLQQ 

    CRAT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CRAT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000746.2  NP_001244292.1  

    ENSEMBL proteins: 
     ENSP00000315013   ENSP00000395458   ENSP00000400367   ENSP00000394420   ENSP00000404405  
     ENSP00000377045   ENSP00000390571  
    Reactome Protein details: P43155
    Human Recombinant Protein Products for CRAT: 
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    Cloud-Clone Corp. Proteins for CRAT 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA2351134
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005777peroxisome IDA2351134
    GO:0005782peroxisomal matrix TAS--
    GO:0005783endoplasmic reticulum IEA--

    CRAT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000542 Carn_acyl_trans

    Graphical View of Domain Structure for InterPro Entry P43155

    ProtoNet protein and cluster: P43155

    1 Blocks protein domain: IPB000542 Acyltransferase ChoActase/COT/CPT

    UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
    Similarity: Belongs to the carnitine/choline acetyltransferase family


    CRAT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CACP_HUMAN, P43155
    Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the
    flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into
    mitochondria
    Catalytic activity: Acetyl-CoA + carnitine = CoA + O-acetylcarnitine

         Genatlas biochemistry entry for CRAT:
    carnitine acetyltransferase,localized in mitochondrial matrix,peroxisomes,and endoplasmic reticulum,specific for
    short chain fatty acyl-CoA (C2-C14)

         Enzyme Numbers (IUBMB): EC 2.3.1.71 2 EC 2.3.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004092carnitine O-acetyltransferase activity IDA15099582
    GO:0005102receptor binding IPI--
    GO:0016746transferase activity, transferring acyl groups ----
         
    CRAT for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Crat):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  muscle 

    CRAT for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CRAT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CRAT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CRAT 
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    hsa-miR-124 hsa-miR-506 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidCRAT 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRAT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CRAT About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    2Peroxisomal lipid metabolism
    Beta-oxidation of pristanoyl-CoA0.38
    Peroxisomal lipid metabolism0.38
    3alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
    Beta-oxidation of very long chain fatty acids0.42
    4Fatty Acid Beta Oxidation
    Fatty Acid Beta Oxidation0.35
    5Peroxisome
    Peroxisome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRAT
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for CRAT
        Fatty Acid Beta Oxidation


    5        Reactome Pathways for CRAT
        Beta-oxidation of pristanoyl-CoA
    Beta-oxidation of very long chain fatty acids
    Metabolism
    Peroxisomal lipid metabolism
    Metabolism of lipids and lipoproteins


    1         Kegg Pathway  (Kegg details for CRAT):
        Peroxisome


    CRAT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRAT

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/17 Interacting proteins for CRAT (P431553 ENSP000003150134) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA6O606843I2D: score=6 
    ABCA3Q997583I2D: score=5 
    HSP90AA1P079003I2D: score=3 
    AURKCQ9UQB93I2D: score=2 
    EIF2B2P497703I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0019254carnitine metabolic process, CoA-linked IDA15099582
    GO:0033540fatty acid beta-oxidation using acyl-CoA oxidase TAS--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CRAT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CRAT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CRAT (CACP)

    7 HMDB Compounds for CRAT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    L-Acetylcarnitine(-)-Acetylcarnitine (see all 14)3040-38-8--
    L-Carnitine(-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate (see all 33)541-15-1--
    Phytanoyl-CoAPhytanoyl-coenzyme A (see all 8)146622-45-9--
    Propionyl-CoAPropionyl-CoA (see all 8)317-66-8--
    Propionylcarnitine(+/-)-Propionylcarnitine chloride (see all 8)17298-37-2--

    3 DrugBank Compounds for CRAT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Carnitine(-)-Carnitine (see all 6)541-15-1target--15099582 12562770 12582227 12526798 15155769
    (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium-- 461-06-3target--17139284 17016423 10592235
    Coenzyme A-- 85-61-0target--17139284 17016423 10592235

    10/112 Novoseek inferred chemical compound relationships for CRAT gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 96.9 830 1427600 (2), 7776973 (2), 19332670 (2), 2123391 (2) (see all 99)
    carnitine 74.8 194 2351134 (6), 1822803 (4), 2325817 (4), 9059510 (4) (see all 64)
    acetyl-l-carnitine 58 13 11121899 (3), 1456745 (1), 10452805 (1), 8239306 (1) (see all 7)
    thymidine 57.1 40 1550597 (1), 7684926 (1), 7608251 (1), 8923463 (1) (see all 33)
    acetyl-coa 53 24 1822803 (2), 19912061 (2), 2351134 (1), 1489081 (1) (see all 15)
    oligonucleotide 49.9 8 17854268 (1), 2142416 (1), 7737192 (1), 2153928 (1) (see all 7)
    12-o-tetradecanoylphorbol 13-acetate 49.6 18 8380829 (2), 1618329 (1), 8955111 (1), 1939341 (1) (see all 12)
    cafestol 43.9 3 9555953 (1), 9351383 (1)
    estrogen 43.3 49 9010318 (3), 9015389 (2), 1572285 (2), 9195474 (2) (see all 30)
    dc-chol 43 4 8332495 (2), 8185568 (1)

    Search CenterWatch for drugs/clinical trials and news about CRAT / CACP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CRAT gene (4 alternative transcripts): 
    NM_000755.3  NM_001257363.1  NM_004003.2  NM_144782.1  

    Unigene Cluster for CRAT:

    Carnitine O-acetyltransferase
    Hs.12068  [show with all ESTs]
    Unigene Representative Sequence: NM_001257363
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318080(uc004bxk.4 uc004bxh.3) ENST00000455396 ENST00000458362
    ENST00000467343 ENST00000464290 ENST00000415948(uc004bxj.2) ENST00000441796
    ENST00000393384 ENST00000455830
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK313931.1 BC000723.2 BT006801.1 DQ655950.2 DQ655951.2 X78706.1 

    14 DOTS entries:

    DT.314546  DT.100780326  DT.100780322  DT.100829697  DT.70100861  DT.100769621  DT.121146271  DT.121146254 
    DT.91750229  DT.101973542  DT.40108104  DT.95249687  DT.95249711  DT.65288393 

    24/273 AceView cDNA sequences (see all 273):

    BU733153 AI612821 BI829245 BG696822 AI278072 AI419719 CD609491 AW664936 
    AI027659 BG740824 BG741927 AI041268 AI291920 BG910562 BM857065 BU527511 
    BM857108 AI492549 R99315 CR615872 AI860023 CF125676 BG742598 AA353269 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRAT (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                                  -                                                                                                         
    SP2:                          -     -     -           -                                                     -     -                                             
    SP3:                                -     -           -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                  -         

    ExUns: 17b · 17c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CRAT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CRAT expression in normal human tissues (normalized intensities)      CRAT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CRAT Expression
    About this image


    CRAT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Blood (Muscoskeletal System)    fully expand to see all 2 entries
             bone marrow   

    See CRAT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CRAT

    SOURCE GeneReport for Unigene cluster: Hs.12068

    UniProtKB/Swiss-Prot: CACP_HUMAN, P43155
    Tissue specificity: Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain,
    placenta, lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including CRAT: 
              Fatty Acid Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CRAT gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Crat1 , 5 carnitine acetyltransferase1, 5 86.42(n)1
    91.05(a)1
      2 (21.69 cM)5
    129081  NM_007760.31  NP_031786.21 
     304004715 
    chicken
    (Gallus gallus)
    Aves CRAT1 carnitine O-acetyltransferase 74.13(n)
    78.73(a)
      417195  XM_415478.3  XP_415478.2 
    lizard
    (Anolis carolinensis)
    Reptilia CRAT6
    --
    --
    79(a)
    55(a)
    1 ↔ 1
    possible ortholog
    GL344059.1(43449-61539)
    2(194656934-194715179)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB180322.12   -- 73.25(n)    CB180322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh02482 hmzeh0248 76.52(n)   321373  CK028362.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51221 , 3 carnitine O-acetyltransferase3
    CG51221
    40(a)
    (best of 4)3
    50.44(n)1
    39.58(a)1
      347031  NM_135757.21  NP_609601.11 
    worm
    (Caenorhabditis elegans)
    Secernentea B0395.31 , 3 choline O-acetyltransferase3
    Protein B0395.31
    37(a)
    (best of 2)3
    47.54(n)1
    38.66(a)1
      X(16066025-16070026)3
    1816821  NM_078223.21  NP_510624.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAT2(YML042W)4
    CAT21
    Carnitine acetyl-CoA transferase present in both mitochondria more4
    Cat2p1
    42.64(n)1
    32.88(a)1
      13(192788-194800)4
    8549651, 4  NP_013670.11, 4 


    ENSEMBL Gene Tree for CRAT (if available)
    TreeFam Gene Tree for CRAT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CRAT gene
    CROT2  CPT1C2  CPT1B2  CPT1A2  CHAT2  
    7 SIMAP similar genes for CRAT using alignment to 6 protein entries:     CACP_HUMAN (see all proteins):
    ChAT    CHAT    CROT    CPT1A    CPT1B    CPT2
    CPT1C

    CRAT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in CRAT are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0477804
    ----see VAR_0477802 L M mis40--------
    rs109882001,2
    C,F,H--101463555(+) GGACAT/CGGGGC 1 -- ds500115Minor allele frequency- C:0.43NS EA NA WA CSA 969
    rs175085161,2
    C,F,H--101463591(+) TGATCG/ACACCT 1 -- ds50015Minor allele frequency- A:0.03NS EA WA 536
    rs1929394461,2
    C--101463618(+) GTCTGC/TCCTGG 1 -- ds50010--------
    rs1476251741,2
    --101463627(+) GGCAGC/TGGCTG 1 -- ds50010--------
    rs1846301121,2
    --101463629(+) CAGCGC/GCTGGG 1 -- ds50010--------
    rs175085231,2
    C,F--101463727(+) TTAGCA/CACATT 1 -- ds50012Minor allele frequency- C:0.15CSA WA 120
    rs31244961,2
    C,F,A,H--101463832(+) AGAGGT/CAGGTG 1 -- ds500110Minor allele frequency- C:0.22NS NA WA CSA EA 490
    rs123428251,2
    C,F,H--101463857(+) AAGGAC/TGCAGC 1 -- ds50017Minor allele frequency- T:0.00NS EA NA 598
    rs174860381,2
    C,F,H--101463886(+) CTGGGC/ACCAGT 1 -- ds50016Minor allele frequency- A:0.08NS EA WA 536

    HapMap Linkage Disequilibrium report for CRAT (131857073 - 131873468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CRAT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509323CNV Insertion20534489
    nsv831729CNV Loss17160897
    nsv818725CNV Gain17921354
    nsv893902CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600184    OMIM disorders: --

    20/73 diseases for CRAT (see all 73):    About MalaCards
    carnitine palmitoyltransferase 1a deficiency    marek disease    thyroid hormone resistance syndrome    mouth disease
    propionic acidemia    glucocorticoid resistance    thyroid medullary carcinoma    acute monocytic leukemia
    monocytic leukemia    estrogen-receptor negative breast cancer    fetal alcohol syndrome    hepatoblastoma
    refsum disease    leydig cell tumor    mitochondrial encephalomyopathy    encephalomyopathy
    hepatitis a    fibrosarcoma    xeroderma pigmentosum    insulinoma


    CRAT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/63 Novoseek inferred disease relationships for CRAT gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma rous 60.1 7 2159467 (1), 11395331 (1), 2187480 (1), 2173259 (1) (see all 6)
    immunodeficiency 54.2 12 2219731 (1), 1705476 (1), 1654446 (1), 10028058 (1) (see all 11)
    leukemia t-cell 52.5 3 8382621 (1), 8494821 (1), 2209540 (1)
    mammary tumor 48.6 20 2159467 (1), 2172802 (1), 1843211 (1), 1372436 (1) (see all 15)
    visna 38 1 1316669 (1)
    hepatoblastoma 37.8 2 8286041 (1), 10400991 (1)
    choriocarcinoma 36.9 5 7588308 (1), 15971268 (1), 8603036 (1), 1964488 (1) (see all 5)
    herpes simplex 36.3 9 11598449 (1), 1584226 (1), 8920984 (1), 10028058 (1) (see all 9)
    erythroleukemia 32.4 4 7945385 (1), 8651934 (1), 7524502 (1)
    carcinoma embryonal 29.7 1 1804740 (1)

    Genetic Association Database (GAD): CRAT
    Human Genome Epidemiology (HuGE) Navigator: CRAT (5 documents)

    Export disorders for CRAT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CRAT gene, integrated from 9 sources (see all 611):
    (articles sorted by number of sources associating them with CRAT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1. (PubMed id 7829107)1, 2, 3, 9 Corti O.... Didonato S. (1994)
    2. Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. (PubMed id 12562770)1, 2, 7, 9 Wu D....McKenna R. (2003)
    3. Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. (PubMed id 15099582)1, 2, 7, 9 Govindasamy L.... Wu D. (2004)
    4. Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations. (PubMed id 7945262)1, 2, 9 Corti O.... Finocchiaro G. (1994)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. (PubMed id 12526798)1, 7 Jogl G. and Tong L. (2003)
    10. Purification and properties of carnitine acetyltransferase from human liver. (PubMed id 2351134)1, 9 Bloisi W....Didonato S. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1384 HGNC: 2342 AceView: CRAT Ensembl:ENSG00000095321 euGenes: HUgn1384
    ECgene: CRAT Kegg: 1384 H-InvDB: CRAT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CRAT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CRAT gene:
    Search GeneIP for patents involving CRAT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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