Aliases for CRAT Gene
External Ids for CRAT Gene
Previous GeneCards Identifiers for CRAT Gene
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for CRAT Gene
CRAT (Carnitine O-Acetyltransferase) is a Protein Coding gene. Diseases associated with CRAT include Carnitine Acetyltransferase Deficiency and Overnutrition. Among its related pathways are Peroxisomal lipid metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include receptor binding and carnitine O-acetyltransferase activity. An important paralog of this gene is CHAT.
UniProtKB/Swiss-Prot for CRAT Gene
Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.