CRAT Gene
protein-coding GIFtS: 64
GCID: GC09M131857
|
|
carnitine O-acetyltransferase(Previous name: carnitine acetyltransferase )
| |
Aliases
for CRAT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Carnitine O-Acetyltransferase1 2 | | CAT2 3 | | CAT11 2 3 5 | | EC 2.3.1.73 8 | | Carnitine Acetyltransferase1 2 3 | | CrAT3 | | Carnitine Acetylase2 3 | | EC 2.3.18 |
| External Ids: | HGNC: 23421 | Entrez Gene: 13842 | Ensembl: ENSG000000953217 | OMIM: 6001845 | UniProtKB: P431553 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408115 | |
Export aliases for CRAT gene to outside databasesPrevious GC identifers: GC09M122971 GC09M123503 GC09M125310 GC09M127233 GC09M128936 GC09M130896 GC09M101464
Summaries
for CRAT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CRAT:
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria,peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoAthioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Apr 2012)
UniProtKB/Swiss-Prot: CACP_HUMAN, P43155Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the fluxthrough the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA intomitochondria
Gene Wiki entry for CRAT
|
Genomic Views
for CRAT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRAT gene promoter:
NF-kappaB YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRAT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CRAT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.1CRAT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M131857: view genomic region
(about GC identifiers)
Start:
|
131,857,073 bp from pter |
End:
|
131,873,468 bp from pter |
Size:
|
16,396 bases |
Orientation:
|
minus strand |
|
Proteins
for CRAT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CACP_HUMAN, P43155 (See
protein sequence)Recommended Name: Carnitine O-acetyltransferase Size: 626 amino acids; 70858 Da
Subunit: Monomer
Subcellular location: Endoplasmic reticulum (Potential). Peroxisome (Potential). Mitochondrion inner membrane;Peripheral membrane protein; Matrix side (Potential)
Subcellular location: Isoform 1: Mitochondrion (Potential)
Subcellular location: Isoform 2: Peroxisome (Potential)
2 PDB 3D structures from  and Proteopedia  for CRAT:1NM8 (3D)
1S5O (3D)
Secondary accessions: Q5T952 Q9BW16Alternative splicing: 3 isoforms: P43155-1 P43155-2 P43155-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CRAT: NX_P43155
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43155
4/13 DME Specific Peptides for CRAT (P43155) (see all 13)
CRAT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000746.2 NP_001244292.1
ENSEMBL proteins: ENSP00000315013 ENSP00000395458 ENSP00000400367 ENSP00000394420 ENSP00000404405 ENSP00000377045 ENSP00000390571 Reactome Protein details: P43155
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CRAT for ontologies About GeneDecksing
CRAT Antibody Products:
Assay Products for CRAT: |
Protein
Domains /
Families
for CRAT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRAT for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P43155ProtoNet protein and cluster: P43155 1 Blocks protein family: IPB000542 Acyltransferase ChoActase/COT/CPT
UniProtKB/Swiss-Prot: CACP_HUMAN, P43155Similarity: Belongs to the carnitine/choline acetyltransferase family |
Function
for CRAT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CACP_HUMAN, P43155Function: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the fluxthrough the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA intomitochondriaCatalytic activity: Acetyl-CoA + carnitine = CoA + O-acetylcarnitine Genatlas biochemistry entry for CRAT:carnitine acetyltransferase,localized in mitochondrial matrix,peroxisomes,and endoplasmic reticulum,specific for shortchain fatty acyl-CoA (C2-C14)
Enzyme Numbers (IUBMB): EC 2.3.1.71 2 EC 2.3.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CRAT (NM_000755) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRAT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRAT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRAT |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CRAT for ontologies About GeneDecksing
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Crat):
CRAT for phenotypes About GeneDecksing
|
Pathways & Interactions
for CRAT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Peroxisomal lipid metabolism | | | 3 | AMPK Enzyme Complex Pathway | | | 4 | Fatty Acid Beta Oxidation | | | 5 | Peroxisome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CRAT
1  BioSystems Pathway for CRAT
5 
Reactome Pathways for CRAT
1 
Kegg Pathway (Kegg details for CRAT):
CRAT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRAT
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/17 Interacting proteins for CRAT (P431553 ENSP000003150134) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CRAT for ontologies About GeneDecksing
|
Drugs & Compounds
for CRAT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CRAT for compounds About GeneDecksing
 Browse Tocris compounds for CRAT
7 HMDB Compounds for CRAT About this table
3 DrugBank Compounds for CRAT About this table
10/112 Novoseek chemical compound relationships for CRAT gene (see all 112) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chloramphenicol |
96.9 |
830 |
1427600 (2), 7776973 (2), 19332670 (2), 2123391 (2) (see all 99) |
| carnitine |
74.8 |
194 |
2351134 (6), 1822803 (4), 2325817 (4), 9059510 (4) (see all 64) |
| acetyl-l-carnitine |
58 |
13 |
11121899 (3), 1456745 (1), 10452805 (1), 8239306 (1) (see all 7) |
| thymidine |
57.1 |
40 |
1550597 (1), 7684926 (1), 7608251 (1), 8923463 (1) (see all 33) |
| acetyl-coa |
53 |
24 |
1822803 (2), 19912061 (2), 2351134 (1), 1489081 (1) (see all 15) |
| oligonucleotide |
49.9 |
8 |
17854268 (1), 2142416 (1), 7737192 (1), 2153928 (1) (see all 7) |
| 12-o-tetradecanoylphorbol 13-acetate |
49.6 |
18 |
8380829 (2), 1618329 (1), 8955111 (1), 1939341 (1) (see all 12) |
| cafestol |
43.9 |
3 |
9555953 (1), 9351383 (1) |
| estrogen |
43.3 |
49 |
9010318 (3), 9015389 (2), 1572285 (2), 9195474 (2) (see all 30) |
| dc-chol |
43 |
4 |
8332495 (2), 8185568 (1) |
Search CenterWatch for drugs/clinical trials and news about CRAT / CACP
|
Transcripts
for CRAT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CRAT gene (4 alternative transcripts): NM_000755.3 NM_001257363.1 NM_004003.2 NM_144782.1 Unigene Cluster for CRAT: Carnitine O-acetyltransferase Hs.12068 [show with all ESTs]Unigene Representative Sequence: NM_00125736310 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000318080(uc004bxk.4 uc004bxh.3) ENST00000455396 ENST00000458362
ENST00000467343 ENST00000464290 ENST00000415948(uc004bxj.2) ENST00000441796
ENST00000393384 ENST00000460708 ENST00000455830
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CRAT (NM_000755) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CRAT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CRAT |
Additional cDNA sequence: AK313931.1 BC000723.2 BT006801.1 DQ655950.2 DQ655951.2 X78706.1 14 DOTS entries: DT.314546 DT.100780326 DT.100780322 DT.100829697 DT.70100861 DT.100769621 DT.121146271 DT.121146254 DT.91750229 DT.101973542 DT.40108104 DT.95249687 DT.95249711 DT.65288393 24/273 AceView cDNA sequences (see all 273): BM857108 AA353269 AI492549 BU517016 BI829245 CD609491 BQ929844 BG910562 AI612821 AI041268 CR615872 AI860023 BG741927 R99315 AW664936 NM_004003 AI027659 AI291920 AI419719 CD609488 BU733153 BG740824 BG697671 CR596033
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CRAT (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | |
| ExUns: | 17b | · | 17c |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for CRAT
|
Expression
for CRAT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CRAT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CRAT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CRAT
SOURCE GeneReport for Unigene cluster: Hs.12068
UniProtKB/Swiss-Prot: CACP_HUMAN, P43155Tissue specificity: Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain,placenta, lung and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including CRAT:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRAT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CRAT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CRAT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CRAT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CRAT |
Orthologs
for CRAT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for CRAT gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CRAT1 |
carnitine O-acetyltransferase |
74.13(n)
78.73(a) |
|
417195 XM_415478.3 XP_415478.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CRAT6 |
-- |
79(a) |
1 ↔ 1 |
GL344059.1(47104-59623) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CB180322.12 |
-- |
73.25(n) |
|
CB180322.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hmzeh02482 |
hmzeh0248 |
76.52(n) |
|
321373 CK028362.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG51221 , 3 |
carnitine O-acetyltransferase3
CG51221 |
40(a)
(best of 4)3
50.44(n)1
39.58(a)1 |
|
347031 NM_135757.21 NP_609601.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0395.31 , 3 |
choline O-acetyltransferase3
Protein B0395.31 |
37(a)
(best of 2)3
47.54(n)1
38.66(a)1 |
|
X(16066025-16070026)3
1816821 NM_078223.21 NP_510624.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CAT2(YML042W)4
CAT21 |
Carnitine acetyl-CoA transferase present in both mitochondria more4
Cat2p1 |
42.64(n)1
32.88(a)1 |
|
13(192788-194800)4
8549651, 4 NP_013670.11, 4 |
ENSEMBL Gene Tree for CRAT (if available)
TreeFam Gene Tree for CRAT (if available) |
Paralogs
for CRAT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CRAT gene
- CROT2 CPT1C2 CPT1B2 CPT1A2 CHAT2
7 SIMAP similar genes for CRAT using alignment to 6 protein entries: CACP_HUMAN (see all proteins):ChAT CHAT CROT CPT1A CPT1B CPT2
CPT1C
CRAT for paralogs About GeneDecksing
|
Genomic Variants
for CRAT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CRAT (131857073 - 131873468 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRAT
1 CNV: 9623 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CRAT |
|
Disorders
/ Diseases
for CRAT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRAT for disorders About GeneDecksing
OMIM gene information: 600184
OMIM disorders: --
20/79  diseases for CRAT (see all 79): About MalaCardsestrogen-receptor negative breast cancer carnitine acetyltransferase deficiency brachial plexus injuries propionic acidemia
xeroderma pigmentosum wiskott-aldrich syndrome carnitine deficiency monocytic leukemia
leydig cell tumor acute monocytic leukemia thyroid hormone resistance syndrome mouth disease
mitochondrial encephalomyopathy herpes simplex burkitt's lymphoma glucocorticoid resistance
marek disease multiple system atrophy thyroid medullary carcinoma encephalomyopathy
1 disease from the University of Copenhagen DISEASES database for CRAT:Fetal alcohol syndrome 10/63 Novoseek disease relationships for CRAT gene (see all 63) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sarcoma rous |
60.1 |
7 |
2159467 (1), 11395331 (1), 2187480 (1), 2173259 (1) (see all 6) |
| immunodeficiency |
54.2 |
12 |
2219731 (1), 1705476 (1), 1654446 (1), 10028058 (1) (see all 11) |
| leukemia t-cell |
52.5 |
3 |
8382621 (1), 8494821 (1), 2209540 (1) |
| mammary tumor |
48.6 |
20 |
2159467 (1), 2172802 (1), 1843211 (1), 1372436 (1) (see all 15) |
| visna |
38 |
1 |
1316669 (1) |
| hepatoblastoma |
37.8 |
2 |
8286041 (1), 10400991 (1) |
| choriocarcinoma |
36.9 |
5 |
7588308 (1), 15971268 (1), 8603036 (1), 1964488 (1) (see all 5) |
| herpes simplex |
36.3 |
9 |
11598449 (1), 1584226 (1), 8920984 (1), 10028058 (1) (see all 9) |
| erythroleukemia |
32.4 |
4 |
7945385 (1), 8651934 (1), 7524502 (1) |
| carcinoma embryonal |
29.7 |
1 |
1804740 (1) |
Human Genome Epidemiology (HuGE) Navigator: CRAT (5 documents)
Export disorders for CRAT gene to outside databases
|
Publications
for CRAT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CRAT gene, integrated from 9 sources (see all 606):
(articles sorted by number of sources associating them with CRAT) | |  | Utopia: connect your pdf to the dynamic
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- Molecular cloning of cDNAs encoding human carnitine acetyltransferase and mapping of the corresponding gene to chromosome 9q34.1. (PubMed id 7829107)1, 2, 3, 9 Corti O.... Didonato S. (1994)
- Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. (PubMed id 12562770)1, 2, 7, 9 Wu D....McKenna R. (2003)
- Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. (PubMed id 15099582)1, 2, 7, 9 Govindasamy L.... Wu D. (2004)
- Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations. (PubMed id 7945262)1, 2, 9 Corti O.... Finocchiaro G. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. (PubMed id 12526798)1, 7 Jogl G. and Tong L. (2003)
- Purification and properties of carnitine acetyltransferase from human liver. (PubMed id 2351134)1, 9 Bloisi W....Didonato S. (1990)
- Carnitine insufficiency caused by aging and overnutri tion compromises mitochondrial performance and metabolic control. (PubMed id 19553674)1, 9 Noland R.C....Muoio D.M. (2009)
- Genomics of the human carnitine acyltransferase genes. (PubMed id 11001805)1, 9 van der Leij F.R....Bartelds B. (2000)
- Carnitine acetyltransferase activity in the human brain and its microvessels is decreased in Alzheimer's disease. (PubMed id 1456745)1, 9 Kalaria R.N. and Harik S.I. (1992)
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External Searches for CRAT gene
(in PubMed,
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Genome Databases showing CRAT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CRAT gene
(According to HUGE)
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Specialized Databases showing CRAT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CRAT | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CRAT gene:
Search GeneIP for patents involving CRAT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CRAT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CRAT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CRAT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CRAT | | | OriGene Protein Over-expression Lysate for CRAT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CRAT | | OriGene 3'-UTR Clone for CRAT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CRAT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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